Epistemology is one of the four perennial philosophical questions(metaphysics, epistemology, philosophical anthropology, and ethics.)

Metaphysics: what is? What's real?

Epistemology: How can we know what is real or most real? 

Anthropology: Who are we? "Know thyself."

Ethics: What should we be, how should we live, and to be more real?

Jesus is the key to these four philosophical questions.