This episode discusses four MMWR reports. First, a new study finds at least 2 doses of COVID-19 vaccine are effective at reducing emergency department visits and hospitalizations in young children. Second, wastewater monitoring helps experts better prepare for and respond to respiratory virus seasons. Third, the 2022 U.S. firearm suicide rate reached the highest level documented. Finally, a greater percentage of young children with HIV on antiretroviral treatment die compared to older individuals receiving similar treatment.