Brain Channel (Video): Recent Episodes
UCTV
Explore the world of neuroscience and the secrets of the brain. Discover how the brain works, technologies to harness brain power, ways to treat disease, and more.
Alzheimer’s disease unfolds over many years through a complex interplay of amyloid, tau, genetics, lipid biology, and the brain’s immune response. John Hardy, Ph.D., explains how rare inherited forms of Alzheimer’s disease helped shape current thinking about how the disease begins, then connects those discoveries to broader questions about late onset disease and why it develops differently across people. Hardy shows that amyloid and tau are linked but not identical, and argues that problems with protein buildup and clearance both matter in understanding the disease. He also emphasizes that Alzheimer’s is not a single event but a long process, which makes prediction, diagnosis, and treatment especially difficult. While current amyloid-targeting therapies can help and show measurable benefit, Hardy says they do not stop the disease, underscoring the need for earlier diagnosis, better treatments, and wider access to care Series: "Shiley Endowed Lecture" [Health and Medicine] [Show ID: 41250]
How fast are you really aging, and what could that mean for brain health? Aladdin H. Shadyab, Ph.D., explores the gap between chronological age and biological age, and why that difference matters for long-term health. Shadyab describes tools that use information from blood to estimate how quickly the body is aging, including approaches that look beyond the body as a whole to consider aging in specific systems. He connects faster biological aging with higher risk for age-related disease and declines in physical and cognitive function, and discusses how blood-based biomarkers may offer earlier signals of processes linked to Alzheimer’s disease. Shadyab also highlights lifestyle and treatment findings that may support healthier aging and longer survival. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41073]
Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]
Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on the effects of exercise on brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40062]
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, and discover actionable steps you can take to protect your brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40061]
What can you do today to improve or maintain your brain health? Join Sarah Banks, Ph.D., a leading expert in healthy aging, dementia, and Alzheimer's disease, as she discusses the latest research on diet and cognitive decline. Learn how diet, vascular health and inflammation contributes to cognitive function and discover actionable steps you can take to protect your brain health. Stay informed and proactive about maintaining cognitive function as you age with insights from cutting-edge research. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40063]
What can you do today to improve or maintain your brain health? Sarah Banks, Ph.D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and corrective tips associated with sleep apnea. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40042]
What can you do today to improve or maintain your brain health? Sarah Banks, Ph.D., an expert in healthy aging, dementia, and Alzheimer's disease, explores risk factors and offers practical tips for enhancing brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 39387]
Claudia H. Kawas, M.D., addresses Alzheimer's disease and related conditions in older adults, noting the challenge of accurate diagnosis and the resemblance of other brain conditions to Alzheimer's. She introduces "resistance" and "resilience," explaining how some individuals remain cognitively intact despite brain changes. Kawas suggests declining dementia risk due to improved vascular health management, emphasizing the complexity of cognitive decline and the need for further research. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 39532]
Alzheimer’s disease is a major health crisis that is projected to become an even larger threat in the coming decades. According to the National Institute on Aging, the number of Americans 65 and older with Alzheimer’s could rise from 5.8 million in 2020 to 13.8 million by 2050. Given the severity of this health crisis and the toll it takes on patients, their families and society, we must be prepared today to address the needs of tomorrow. Dean Frank LaFerla of UC Irvine's School of Biological Sciences presents an overview of the state of Alzheimer’s disease research. Following his presentation, the panel discusses emerging trends in research, care and the upcoming challenges we will face and how we might mitigate them. [Health and Medicine] [Show ID: 38660]
Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]
Dr. Songi Han, professor in the Department of Chemistry, Biochemistry and Chemical Engineering at UC Santa Barbara, talks about her research into the function of proteins in the body and how changes like protein Tau tangles can lead to neurological diseases like Alzheimer's. Series: "GRIT Talks" [Health and Medicine] [Science] [Show ID: 37869]
What is it like to be an adult with autism? A panel shares their journeys as well as the impact the pandemic has had on their lives. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 37656]
Join a panel of typers as they explore the underlying themes of Daniel Keyes' "Flowers for Algernon." Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Humanities] [Science] [Show ID: 37657]
The COVID-19 pandemic has resulted in unprecedented changes in routines across the globe. For individuals with autism (ASD) changes in routine can have a direct impact on behavioral symptoms. Doris Trauner, MD examines the effect the pandemic has had on children with moderate to severe autism. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 37654]
Constance Smith-Hicks, MD, PhD provides an overview of the sensory challenges in autism spectrum disorder and explains how the sensory system develops. Learn about the somatosensory system as well as current treatments. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 37653]
What is the prevalence of epilepsy in individuals with autism? Brian Moseley, MD explores the connection and influencing factors. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 37660]
How can the principles of precision medicine apply to autism? Elizabeth Torres, PhD, shares how it has shaped her research. She also explains the three contemporary revolutions in science that have impacted research - neuroscience, genomics, and wearables. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 37659]
How can employers and universities better support individuals with autism? A panel of experts including parents, employers, and researchers discusses the support programs that currently exist and what needs to change to make sure neurodiverse people are successful in the world of work and in post-secondary education. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 37655]
Dhakshin Ramanathan, MD, PhD, explains the basics of neuroscience and how brain stimulation works. He takes a deep dive into Transcranial Magnetic Stimulation (TMS) noting how it works, why it works, and its efficacy as a treatment. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37609]
Tarek Rajji, MD, shares research from current trials combining brain stimulation with interventions including cognitive remediation. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37598]
What is magnetic brain stimulation and how can it be used to improve our health? Dhakshin Ramanathan, MD, PhD, and Zafiris "Jeff" Daskalakis, MD, PhD, join Jyoti Mishra, PhD, to discuss how and why to use therapies such as TMS and MST to treat depression. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37597]
Can virtual classes help seniors with fall prevention and staying fit? What are the impacts of diet on inflammation and mental health? Jeanne Nichols, PhD, and Mark Rapaport, MD, detail their respective work in mental and physical well-being. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 37593]
Dr. Georges Naasan discusses communication difficulties associated with the language syndrome of Alzheimer's Disease. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 37334]
Dr. Georges Naasan describes the symptoms seen in the frontal/executive syndrome of Alzheimer's disease. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 37335]
Neural imaging is a useful technique to understand the biological basis of artistic creativity. Post-doctoral Scholar Karen Chan Barrett explores how researchers measure the creative brain in real time noting that improvisation is a rich model for studying the neural connections of creativity. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 37148]
Research suggests that listening to or singing songs can provide emotional and behavioral benefits for people with Alzheimer's disease. Dr. Theresa Allison provides an overview of music in the context of dementia and caregiving relationships. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 37150]
Mark Tuszynski, MD, Ph.D., Bob Yant, and Lawrence S.B. Goldstein, Ph.D. discuss the newest research and treatments for spinal cord injury, including how neural stem cells may be leveraged to potentially regain function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37102]
Hear directly from the team that developed the groundbreaking ability to make new, healthy neurons that can replace those lost in Parkinson’s disease and their vision to turn their discovery into a life-changing therapy. Series: "Innovations Shaping the Future of Parkinson's Disease Treatment " [Health and Medicine] [Show ID: 37041]
Discover how experts in cell biology are partnering with a pioneer in imaging technology to develop a personalized approach to treating Parkinson’s disease. Series: "Innovations Shaping the Future of Parkinson's Disease Treatment " [Health and Medicine] [Show ID: 37040]
Learn how social workers and a patient advocate are partnering to develop a suite of free support programs and services for Parkinson's disease patients and their care partners in San Diego. Series: "Innovations Shaping the Future of Parkinson's Disease Treatment " [Health and Medicine] [Show ID: 37038]
Hear how a team of interdisciplinary experts solved the structure of LRRK2, a gene found to be mutated in Parkinson’s disease, and how their discovery is guiding the way for new targeted therapeutics. Series: "Innovations Shaping the Future of Parkinson's Disease Treatment " [Health and Medicine] [Show ID: 37039]
Irene Litvan, MD Joseph Wang, MD explain how experts are collaborating across disciplines to adapt wearable technology to automate medication management, offering a greater quality of life for individuals with Parkinson’s disease. Series: "Innovations Shaping the Future of Parkinson's Disease Treatment " [Health and Medicine] [Show ID: 37037]
Robert L Hendren, DO, Professor of Psychiatry and Behavioral Science discusses how to build resilience in children with or at risk of neurodevelopmental disorders through innovative biomedical and resilience enhancing interventions. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36870]
Researchers are exploring the exciting possibility that electrical stimulation of nerve cells of brain and spinal cord could aid in tumor resections, monitor epilepsy, bypass spinal cord injury to cure paralysis, as well as treat other diseases of the nervous system and beyond. Bioelectronic neuromodulation devices are evolving as the gold standard and are projected to impact the lives of millions of people. At UC San Diego, collaborations across engineering and medicine aim to bring the latest technological advances to patient care. Shadi Dayeh, Professor, Department of Electrical and Computer Engineering, UC San Diego, covers the development and clinical translation of UCSD’s multi-thousand channel microelectrode arrays to map the human brain and spinal cord. The talk will provide a perspective on global efforts in neuromodulation devices and summarize lessons learned in the technological, medical, and regulatory fronts. Series: "Exploring Ethics" [Health and Medicine] [Science] [Show ID: 36819]
Stem cell research is changing the way Alzheimer's disease is diagnosed and treated. Larry Goldstein, PhD and Doug Galasko, MD join Alysson Muotri, PhD to share the latest findings and what the future may hold. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36805]
As a neurologist, Robert Knight has seen what happens when the brain crashes around violently inside the skull. And he’s aware of the often tragic consequences. Throughout his 40 years as an academic researcher and medical doctor, the University of California, Berkeley, professor of psychology and neuroscience has known students and friends whose lives and careers were derailed by head injuries from bicycle and car crashes. He’s held in his hands brains destroyed by accidental blows to the head. Not surprisingly, he cringes when he imagines his young grandchildren falling off a bike and hitting their heads. So, Knight invented a better helmet — one with more effective padding to dampen the effects of a direct hit, but more importantly, an innovative outer shell that rotates to absorb twisting forces that today’s helmets don’t protect against. Series: "UC Berkeley News" [Health and Medicine] [Science] [Show ID: 36761]
This presentation explores the role of radiotherapy in the management of central nervous system (CNS) tumors and the possible neurological complications of radiotherapy. Dr. Steve Baunstein also discusses the techniques to improve the therapeutic ratio in CNS radiotherapy. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36507]
Lawrence S.B. Goldstein, PhD discusses his career in science and his work to understand the molecular basis of neuronal defects in Alzheimer's Disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36338]
Stem cell research is providing hope for new therapies to treat neurodegenerative diseases. Hear from those on the front lines about what is next.
Moderated by Clive Svendsen, PhD, Cedars-Sinai HD Care: Patient Support Perspective Ralph Kern MD MHSc, Brainstorm Cell Therapeutics: NurOwn (autologous MSC-NTF cells) in ALS- phase 3 clinical trial update Jeanne F. Loring, PhD, Aspen Neuroscience: Neuron replacement therapy for Parkinsons disease Leslie Thompson, PhD, UCI: Stem Cell Based Therapy for Huntington's Disease Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36323]
Jeanne F. Loring, PhD Aspen Neuroscience Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36321]
Kevin Petrecca, MD, PhD, FRCS(C) presents his paper as published in the July 8, 2020 issue of Nature. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36173]
Ralph Kern MD MHSc Brainstorm Cell Therapeutics Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36320]
Leslie Thompson, PhD UCI Series: "Women in Science" [Health and Medicine] [Science] [Professional Medical Education] [Show ID: 36322]
Researcher Alysson Muotri is using stem cells to study everything from autism to the Zika virus. In this excerpt Muotri discusses stem cell and brain organoid research for possible applications to human diseases. Series: "Health Matters" [Health and Medicine] [Show ID: 36301]
Xiang Dong Fu, PhD shares the findings of his paper published in the June 24, 2020 issue of Nature. By investigating a strategy to directly convert astrocytes to dopaminergic (DA) neurons in the substantia nigra, the research shows a potentially powerful and clinically feasible approach to treating neurodegeneration by replacing lost neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36179]
Irene Litvan, MD; Don Cleveland, PhD; and David Higgins, PhD, discuss the next generation of treatments for Parkinson's Disease and offer a patient's perspective in this conversation on the cutting edge stem cell research. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36076]
Interactive immune systems are at the center of cancer and other diseases. Dr. Matthew Krummel explores some lesser-known functions of the immune system related to memory making, arteriosclerosis, and gut health. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36205]
Dr. Aimee Kao discusses key behaviors known to protect brain health. Dr. Kao looks at population trends and wonders if they tell a complete story. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 36154]
Dr. Michael Wilson is a neurologist who specializes in infectious and autoimmune syndromes of the central nervous system. These include inflammatory conditions, such as meningitis, encephalitis and myelitis. In this talk he looks at new treatments being developed. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 35926]
In times of stress, anxiety, and isolation finding effective strategies to understand our emotions and how we relate to the world at large often brings comfort. Mindfulness, meditation, and compassion have long been championed as helpful strategies but how do they impact our well being, if at all? Fadel Zeidan joins William Mobley to discuss his work applying scientific methods to these practices to quantify and discover how and why they work. Series: "Brain Channel" [Health and Medicine] [Humanities] [Science] [Show ID: 35824]
How wisdom is defined and measured in the laboratory, the biology of wisdom, its dynamic relationship with culture, wisdom and aging, wisdom and health, and how we might build wiser societies. THis animation is based on "The New Science of Practical Wisdom" published by Johns Hopkins University Press in the journal Perspectives in Biology and Medicine. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 35488]
Millions of Americans have difficulties with their physical functioning. Dr. Karunesh Ganguly explores the Brain-Computer Interface (BCI). The concept of bio-interactive neural interfaces sates to the early 20th century with successes like cochlear implants, deep brain stimulation and responsive stimulation. He is now working on neural interfaces for communication and movement by working to translate neural engineering based approaches into treatments for those with impaired function. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 35242]
Dr. Aimee Kao looks at recent news in Alzheimer's Disease therapeutics including drugs in development and the potential of stem cells and genome editing. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 35238]
Recently, some scientists have asked whether neural organoids will ever be conscious, and have wondered about the ethical implications of this possibility. Meanwhile, some philosophers have argued that neural organoids are miniature versions of “brains in vats.” Evan Thompson feels that both scientist and philosophers should shift their thinking. He argues that the minimal instantiation of sentience is organismic - not just neuronal, and that conscious processes of moral interest require embodiment and the capacity to suffer.
Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Show ID: 35248]
What defines consciousness? Can it develop in a petri dish? Patricia Churchland reviews the current state of brain organoid research and shares her views on how conciseness and physical structures within the brain intersect. She also cautions the media on the tendency to "over hype" new research advances. Series: "Women in Science" [Health and Medicine] [Humanities] [Show ID: 35247]
As brain organoids become more widely used in research, concerns about the development of consciousness arise. Christof Koch discusses how we determine and define consciousness and how we look for the underlying physical signatures of consciousness. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Science] [Show ID: 35246]
The study of brain organoids is leading to a better understanding of human development and potential therapies for neurological disorders. Yet when people hear the phrase "brain in a dish" it instantly brings to mind the stuff of science fiction - labs full of sentient brains thinking and plotting. Alysson Muotri explains why these organoids should not called "brains in a dish" and how they are being used to explain human processes previously inaccessible to study. While underscoring scientific value of these organoids, he also raises the question of what ethical questions demand an answer as the technology improves. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Show ID: 35245]
David M. Holtzman, MD of the Washington University School of Medicine discusses the mechanisms underlying neurodegeneration and how microglia and specific microglial genes such as TREM2 influence neurodegeneration in the setting of Aβ and tau pathology. Learn how this line of study may lead to new therapeutics and diagnostic testing for Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 35262]
Worldwide 50 million people live with dementia. By 2040 over 70% of them will be living in the developing world. Dr. Shamiel McFarlane explores the social and economic cost of dementia around the world. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34779]
There are modifiable behaviors that may reduce the risk factor of Alzheimer's: vascular disease, sedentary lifestyle, depression/stress, diet factors and alcohol. Kaitlin Casaletto talks about the benefits of an active lifestyle and proper nutrition. Then Dr. Joanna Hellmuth looks at how to decode direct-to-consumer interventions - dietary supplements - and the rise of pseudo-medicine for dementia. She explains that supplements may or may not be safe and that manufacturers can make broad claims without supporting evidence. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 35136]
Dr. Julio Rojas-Martinez discusses the pharmacological treatment of Alzheimer’s disease now and what is in development. Current approaches pursue early intervention in the dementia phase. Novel emerging strategies will likely accompany anti-amyloid and anti-tau approaches in the future. Then Sarah Dulaney, RN, describe dementia education, support, and non-pharmacological treatment strategies. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34777]
Alzheimer’s disease is the most common but not the only cause of dementia throughout the lifespan. Dr.Salvatore Spina discusses frontotemporal dementias and how they differ. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34776]
Dr. Georges Naasan explores the principal clinical syndromes of Alzheimer's Disease: memory, visual, language and frontal/executive. He also discusses neuropathology, genetic factors and modern biomarkers with colleagues from the UCSF Memory and Aging Center. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34775]
Neurologist Dr. Serggio Lanata explores the neurodegenerative disease of the brain, what they have in common and how they differ. alzheimer's is the most common neurodegenerative disease but there are several others including Parkinson's, Huntington Disease and others. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 34774]
More than 5 million Americans are currently diagnosed with Alzheimer’s disease, and that number is expected to triple by 2050, without prevention or cure. By 2060, the number of Latinos in the United States living with Alzheimer’s disease is projected to increase 832 percent — from 379,000 in 2012, to more than 3.5 million. Find out what UC San Diego is doing to both serve this community and catalyze the research careers of investigators from underrepresented groups. Series: "Brain Channel" [Health and Medicine] [Show ID: 34417]
Alex Figueroa and Dr. Jose Soria-Lopez discuss clinical symptoms of Alzheimer's Disease and the need to include the Latino community in clinical research. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 34416]
Rudolph Tanzi, PhD, of the Harvard Medical School describes a fundamental problem with modern-day treatment of Alzheimer's disease. Series: "Wellbeing " [Health and Medicine] [Show ID: 34243]
Dale Bredesen, MD, UCSF and UCLA, discusses how environmental toxins may lead to Alzheimers disease. Series: "UCSF Consortium for Obesity Assessment, Study and Treatment" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 34090]
There are different types of genetic influences on people's risk of developing Alzheimer's disease. Douglas Galasko, MD, of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center joins William Mobley, MD, PhD to discuss these genes, how they are being studied, and what being a carrier of Alzheimer's associated genes means. Learn more about penetrance and expressivity, genome-wide association studies, and more. Series: "Brain Channel" [Health and Medicine] [Show ID: 33725]
How do you model a disease process that stretches out over 20 years in a way that helps you intervene in that process? In the inaugural Shiley Endowed Lecture, Bradley Hyman, MD, PhD shares his research on the progression of Alzheimer's disease. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 33992]
Jennifer A. Dresen, MSW, MPH. Chief of Health and Housing Services, The Arc San Francisco Series: "Developmental Disabilities Update" [Health and Medicine] [Education] [Professional Medical Education] [Show ID: 33522]
Michael Rafii, MD, PhD describes the conditions that affect people with Down syndrome including vision issues, hearing issues, hormonal issue, spinal cord issues, sleep apnea, and Alzheimer's disease. He stresses the need for routine medical follow ups with primary care physicians and specialty clinics to make sure all changes in health are addressed. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 33603]
Karen Gaffney, advocate and disability champion, discusses her life with Down syndrome. She also talks about the impact that pre natal testing is having on the Down syndrome community and advocates for medical research to focus on the immediate needs such as Alzheimer's disease prevention. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 33602]
William Mobley, MD, PhD shares the latest research on preventing Alzheimer's disease in people with Down syndrome. He looks at the genetics and progression of both conditions and shares potential therapies to reduce APP expression that leads to dementia. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 33600]
Can (Martin) Zhang of Harvard Medical School leads off the panel with a detailed discussion of factors leading to Alzheimer’s disease and the potential benefits of curcumin in treatment. He is followed by Rinchen Dhondrup of Qinghai University, who presents on treating chronic atrophic gastritis and Chenchen Wang of Tufts University who explains her work using Tibetan medicines and Tai Chi to treat rheumatoid arthritis, fibromyalgia and other chronic diseases as part of the Tibetan Medicine Conference on Mind-Body Health held at Harvard in October, 2017. Series: "Wellbeing " [Health and Medicine] [Show ID: 33048]
Keynote talks at the 2017 Tibetan Medicine Conference on Mind-Body Health are presented here, including Rudolph Tanzi, PhD, of the Harvard Medical School who describes his research with natural products to prevent and treat Alzheimer's; Yumba of Lhasa on the Great Treasury of Tibetan Medical and Astronomical Texts; and Janet Gyatso of the Harvard Divinity School on the Challenges for the Study of Tibetan Medicine. Series: "Wellbeing " [Health and Medicine] [Show ID: 33044]
Can we turn off the genes responsible for neurodegenerative diseases? Designer DNA drugs are making this possible. By identifying and targeting the genes that drive disease, scientists are moving closer to treatments for ALS, Huntington's disease, and more. Don W. Cleveland, PhD, Department of Cellular and Molecular Medicine, UC San Diego joins William Mobley, MD, PhD to talk about how these drugs work and how they will impact patient care. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 32505]
Igor Grant, MD, FRCP(C) pursues research that addresses real world behavioral problems. Studying the intersection of drugs of abuse (primarily methamphetamine) and infection, his work sheds light on the basic mechanisms of injury for people with HIV. He examines inflammation in the context of neurological disorders and measures the impact of chronic stress on Alzheimer's disease caregivers. Dr. Grant joins William Mobley, MD, PhD to discuss his life in science and his fascinating work. Series: "Brain Channel" [Health and Medicine] [Show ID: 32221]
2016 Kavli Prize recipient Carla Shatz from Stanford University presents a lively exploration of how understanding early stages of neural development may be leading to a pathway for developing treatments for Alzheimer's Disease. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 31763]
Eric Siemers, MD, Distinguished Medical Fellow at Eli Lilly and Company joins William Mobley, MD, PhD to discuss clinical trails for Alzheimer's disease. He explains the trial design, results, and future implications of the EXPEDITION3 trial for people with with mild dementia due to Alzheimer's disease. Learn more about potential treatments in the clinical trials pipeline that may impact both the symptoms and pathologies of Alzheimer's disease. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 31802]
As baby boomers age, an unprecedented number of people will be diagnosed with Alzheimer's disease. The economic and social impacts will be wide reaching from cost of treatment to the effect on caregivers. Maria Carrillo, PhD, Chief Science Officer, Alzheimer’s Association joins Willliam Mobley. MD, PhD to discuss what can be done and how government, industry and the Alzheimer's Association are working together on larger scale trials and innovative projects. Series: "Alzheimer’s Disease" [Health and Medicine] [Show ID: 31801]
Ara Khachaturian, PhD, chair and president of the National Biomedical Research Ethics Council joins WIilliam Mobley, MD, PhD to discuss the evolution of biomedical research in Alzheimer's disease and the ethical standards needed to maintain excellent patient care. From institutional review boards (IRB) to industry and academic partnerships, learn how we can support and maintain effective research infrastructure. Series: "Alzheimer’s Disease" [Health and Medicine] [Show ID: 31770]
Phyllis Ferrell, Vice President and Global Development Leader for Alzheimer's Disease at Eli Lilly and Company joins William Mobley, MD, PhD to talk about the goal set forth in the National Plan to Address Alzheimer’s Disease to “prevent and effectively treat Alzheimer’s disease by 2025.” Ferrell's shares her work to make Alzheimer's dementia preventable by finding ways to slow disease progression and advocating for early diagnosis. Series: "Alzheimer’s Disease" [Health and Medicine] [Show ID: 31803]
From neuropathology to molecular target to clinical treatments, where are we on the road to finding an effective treatment for Alzheimer's disease? Howard Feldman, MD, FRCP(C), a neurologist noted for his original research in geriatric cognitive disorders and expertise in large-scale clinical trials, walks through the latest research and shares some tips on brain health. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Science] [Show ID: 31035]
For the past three decades the largest family in the world with a genetic form of Alzheimer’s disease has been tracked. This extended family of some 5,000 individuals live in Antioquia, Colombia among a people who call themselves Paisa. Passing relentlessly through the generations with 100% penetrance is a mutation that causes early onset Alzheimer’s disease in its carriers. Dr. Kenneth Kosik explains that the mutation in the Americas likely originated from a Spanish conquistador whose progeny are the members of the family we see today. Recently, interest in the family has grown because they are now participating in a clinical trial intended to delay the onset of the disease. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 31481]
Dr. Elissaios Karageorgio explains the link between broken sleep patterns that are characteristic of insomnia and dementia. Series: "Wellbeing " [Health and Medicine] [Show ID: 31201]
What is the relationship between sleep, brain health, and Alzheimer's disease? Series: "Wellbeing " [Health and Medicine] [Show ID: 31286]
Dr. Gary Small talks about how to reprogram brain chemistry through repetition, and highlights which foods the brain-conscious dieter eat. Series: "Wellbeing " [Health and Medicine] [Show ID: 31229]
A panel of experts discusses the PBS NOVA program Can Alzheimer's Be Stopped? and the disease itself. Join Kenneth Kosik, MD (Co-Director Neuroscience Research Institute UC Santa Barbara), Sarah Holt (Producer and Director HHMI/Tangled Bank Studios), and Rhonda Spiegel (CEO, Alzheimer’s Association, California Central Chapter) and Francisco Lopera, MD (Professor of Behavioral Neurology, Chief of Neurosciences Program-University of Antioquia, Coordinator Group of Neurosciences of Antioquia). The discussion is moderated by Julia Cort, Deputy Executive Producer for NOVA. Series: "Carsey-Wolf Center" [Health and Medicine] [Humanities] [Show ID: 31017]
Dr. Gary Small examines the correlation between inflammation and memory loss, and explains why exercise may have the power to stave off the effects of Alzheimer’s disease. Series: "Wellbeing " [Health and Medicine] [Show ID: 31228]
The film Still Alice explores early-onset Alzheimer's disease. This panel at UCSB discusses the film and the troubling issues it explores. Donna Beal - Alzheimer’s Association, Patricia Cline Cohen - Department of History at UCSB, Kenneth Kosik - Neuroscience Research Institute at UCSB. Moderator - Laury Oaks - Feminist Studies at UCSB. Series: "Carsey-Wolf Center" [Health and Medicine] [Humanities] [Show ID: 30803]
With our aging population the incidence of brain disorders such as Alzheimer’s disease are predicted to reach epidemic proportions. Look at AD and other neurodegenerative disorders. Series: "Mini Medical School for the Public" [Health and Medicine] [Show ID: 30142]
Six in ten people with dementia will wander. Hear about the programs that are available to help bring them home safe. Linda Cho, executive director of Stellar care, joins William Mobley, MD, PhD to discuss the problem of wandering and how to create a home environment that facilitates safety and comfort. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 28834]
How can communities better support the growing number of people affected by Alzheimer’s disease? Mary Ball, president and CEO of the Alzheimer’s Association, San Diego and Imperial Counties Chapter joins William Mobley, MD, PhD to discuss how her organization is trying to make a difference through information, support, and partnerships with local government. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 28724]
Choosing residential care for a loved one if often a difficult decision. Linda Cho, executive director of Stellar care, joins William Mobley, MD, PhD to talk about the new models of residential care, family involvement, care with dignity and more. Series: "Brain Channel" [Health and Medicine] [Science] [Show ID: 28955]
What insights into Alzheimer’s disease can cutting edge imaging techniques reveal? James Brewer, MD, PhD joins William Mobley, MD, PhD to discuss how this unique wiindow into the brain can be used to study the progression of the disease as well as help test new therapies. Series: "Alzheimer’s Disease" [Health and Medicine] [Science] [Show ID: 28836]