Foot-and-mouth disease (FMD) remains endemic in East-Southeast Asia, Middle East and North Africa causing significant economic losses; multiple variants of serotypes FMDV O and A are currently circulating. FMD vaccines from Argentina, are widely used in South America and in some countries in Asia and they have shown excellent efficacy in controlling FMD in these regions. Here we report satisfactory in vitro and in vivo vaccine matching studies of FMD vaccines formulated with O1 Campos, A24 Cruzeiro and A2001 Argentina vaccine strains against Type O and A field viruses circulating in endemic regions.