Transplantation: Recent Episodes
ReachMD
Host: Matt Birnholz, MD
Guest: Donald Kohn, MD
Third-generation lentiviral vectors were developed to improve upon safety measures and mitigate the risks of toxicity and replication that are typically associated with first- and second-generation therapies. These advancements may help enhance the functionality and utility of third-generation lentiviral vectors in various gene therapy applications. Learn more about the development, efficacy, and safety of third-generation lentiviral vectors with Dr. Matt Birnholz and Dr. Donald Kohn, Distinguished Professor at the University of California, Los Angeles.
This non-certified educational series is produced and controlled by ReachMD, and is intended for healthcare professionals only.
Host: Jay Fishman, MD
With a global shortage of human organs, xenotransplantation offers a potential new way to save lives. But what are the immunologic barriers? Tune in as Dr. Jay Fishman, Director of Transplant Infectious Diseases and Compromised Host Program at Massachusetts General Hospital, recaps his session from the 2023 IDWeek.
Host: Peter Buch, MD, FACG, AGAF, FACP
Guest: Alan Bonder, MD
According to the United Network for Organ Sharing (UNOS), more than 95 percent of patients are alive and doing well after a liver transplant. So what else can we learn from UNOS? Join Dr. Peter Buch as he speaks with Dr. Alan Bonder, Assistant Professor of Medicine at Harvard Medical School.
Host: Lee P. Shulman, MD, FACMG, FACOG
Guest: Alexandra Benachi, MD, PhD
Guest: Julien Zuber, MD, PhD
Program Chairman:
Roberto Romero, MD, DMedSci
Chief, Perinatology Research Branch
Division of Maternal-Fetal Medicine and Obstetrics
Division of Intramural Research
NICHD/NIH/DHHS
Editor-in-Chief for Obstetrics
The American Journal of Obstetrics and Gynecology
There exists a long-standing controversy about drawing parallels between transplant and pregnancy immunology. Listen in as Drs. Alexandra Benachi, Julien Zuber, and Lee Shulman discuss why these considerations are so important for you and your colleagues, patients, and their families to understand. Discover how links between kidney transplantation and maternal anti-fetal rejection may impact your practice and spark new pathways in medicine.
Host: Peter Buch, MD, FACG, AGAF, FACP
Guest: Koji Hashimoto, MD, PhD
What facts should we keep in mind when considering liver transplantation? And how do we determine which of our patients are the right candidates? Dr. Peter Buch explores important considerations for liver transplantation with Dr. Koji Hashimoto, the Director of Liver Transplantation at the Cleveland Clinic.
Host: John J. Russell, MD
Guest: Paul Craddock, PhD
Beginning in the mid-16th century up until present day, medicine has evolved tremendously. How did transplant surgery play an important role in doing so? Dive into the teachings with Dr. Paul Craddock, author of the book titled, Spare Parts: The Story of Medicine Through the History of Transplant Surgery, as he joins Dr. John Russell to dissect the surprising history of modern medicine.
Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Nick Kusnezov, MD
Can you balance locum tenens with a full-time career? To answer that question, Dr. Charles Turck is joined by board-certified orthopedic surgeon, Dr. Nicholas Kusnezov, to walk us through his journey from joining the military to locum tenens.
Host: Jennifer Caudle, DO
Guest: Roni Devlin, MD
As rates of burnout continue to rise in the healthcare community, how can help our female physicians combat it? Dr. Jennifer Caudle joins Infectious Disease Specialist, Dr. Roni Devlin, to discuss how we can prevent burnout for female physicians.
Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Trevor Cabrera, MD
What’s it like becoming a locum tenens physician right out of residency? Dr. Charles Turck joins Dr. Trevor Cabrera, a Board-Certified pediatrician who trained in Houston, Texas, to share his firsthand experience and offer advice for residents.
Host: Jennifer Caudle, DO
Guest: Maurice G. Sholas, MD, PhD
After years of serving the New Orleans community, one physician decided to pursue locum tenens work. Dr. Jennifer Caudle joins Dr. Maurice Sholas, a pediatric physical rehabilitation physician, to share his experiences with locum tenens and in New Orleans.
Host: Paul P. Doghramji, MD, FAAFP
Guest: Samantha Conroy, MD
Locum tenens can improve quality of care around the globe—especially in remote and underserved communities. To share how, Dr. Paul Doghramji joins Dr. Samantha Conroy, a family practice obstetrician to share her experiences working as a locum tenens obstetrician in underserved communities.
Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Trevor Cabrera, MD
What’s it like becoming a locum tenens physician right out of residency? Dr. Charles Turck joins Dr. Trevor Cabrera, a Board-Certified pediatrician who trained in Houston, Texas, to share his firsthand experience and offer advice for residents.
Host: Matthew Sorrentino, MD
Guest: Javed Butler, MD, MBA, MPH
In a groundbreaking procedure, a 57-year-old man with life-threatening heart disease received a heart from a genetically altered pig. Surgeons at the University of Maryland Medical Center performed the 8-hour operation, making it the first successful transplant of a pig's heart into a human being. And while much is still uncertain, what could this achievement mean for the future of organ transplantation? That’s what ReachMD hosts Dr. Matthew Sorrentino and Dr. Javed Butler explore together.
Please note: Since the date of publication, David Bennet, the patient who received a heart transplant from a pig, died at the age of 57 at the University of Maryland Medical Center on March 8, 2022.
Host: John J. Russell, MD
Guest: Joseph E. Bavaria, MD
Featuring a wide range of disciplines and a new approach to comprehensive care, what do we need to know about the Aorta Center at Penn Medicine? Dr. John Russell is joined by Dr. Joseph E. Bavaria to dive into this aortic program and discuss a new approach to comprehensive care.
Host: Neilanjan Nandi, MD
Guest: Karen Krok, MD, FAASLD
While hepatologists can help gastroenterologists manage the pulmonary manifestations that may occur in our patients with chronic liver disease, it’s still important for gastroenterologists to know what they should be on the lookout for so that patients can receive timely and appropriate treatment. Additionally, gastroenterologists need to consider the potential impacts of those pulmonary manifestations on transplant outcomes. Joining Dr. Neil Nandi to discuss those and other key considerations gastroenterologists need to know is Dr. Karen Krok from Penn State Health Milton S. Hershey Medical Center.
Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Kathryn Gallagher, MS, RN, BSN
Guest: Kate Newcomb-DeSanto, MSN, RN, MSW
What does Penn Medicine’s newly-opened patient room facility have to offer? Dr. Charles Turck is joined by Penn Medicine Clinical Advisors Kathy Gallagher and Kate Newcomb-DeSanto to discuss the new pavilion and how it's revolutionizing patient care.
Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Sandy Marks
Guest: Kim Horvath, JD
Guest: Kyle Thomson, JD
With telehealth services expanding during the COVID-19 pandemic, has our access to them changed? To better understand this, Dr. Charles Turck meets with Sandy Marks, Kim Horvath, and Kyle Thomson from the AMA to explore what’s been done to provide Medicare coverage during a public health emergency and what’s on the horizon for telehealth access.
Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Emily Carroll, JD, MSW
The No Surprises Act aims to protect consumers from surprise medical bills. But how exactly does it go about doing that, and what’s the current status of its implementation? Joining Dr. Charles Turck to share progress and challenges associated with the No Surprises Act is Ms. Emily Carroll, a senior legislative attorney for the American Medical Association's Advocacy Resource Center.
Host: Jennifer Caudle, DO
Guest: Sarah Ali, MD
From working in a big city to taking on an assignment in a small mountain village, Dr. Sarah Ali from the Ventura County Medical Center joins Dr. Jennifer Caudle to talk about her adventures abroad with locum tenens and share key lessons she learned along the way.
Host: Paul P. Doghramji, MD, FAAFP
Guest: Mojgan Saber, MD
Can Locum Tenens be an option for healthcare professionals just completing their residency? Dr. Paul Doghramji is joined by Dr. Mojgan Saber to share her own experience as well as tips and tricks for residents looking at Locum Tenens right after residency.
Host: Charles P. Vega, MD
Guest: Lionel Phillips, MBA
Learn why diversity in clinical trials is so important to community health. Two experts discuss the key role that trusted messengers play in enrollment, why it is critical to break the cycle of medical mistrust, and the downstream effect of a lack of diversity in clinical trials.
Host: Charles P. Vega, MD
Guest: Robert O. Roswell, MD, FACC, FACP
Diversifying our physician workforce so that it is more racially, ethnically, and geographically balanced can ultimately have a positive impact on community health. Join us as two experts discuss how pipeline programs reaching children as early as elementary school can help ensure workplace diversity. Also find out how clinicians can be advocates for their patients by helping to disentangle them from structural inequities and working towards policy changes. There’s a lot than can be done to provide more balanced care, but we need to look beyond simple fixes to the root causes of the issues. So find your bandwidth – that’s what you can do today – and discover why it’s so important to move upstream to solve the problems manifesting downstream.
Host: Charles P. Vega, MD
Guest: Candice Taylor Lucas, MD, MPH, FAAP
What is cultural humility, and how can it be incorporated into clinical practice? How does your patient's culture impact their health behaviors, and why does your culture matter?
Listen in as two leading experts navigate concerns surrounding cultural humility and emphasize the importance of empathy, awareness, and advocacy. Discover ways to integrate small but important changes into your clinical practice to help bridge communication gaps and enable your patients to thrive.
Host: Charles P. Vega, MD
Guest: Sateria Venable
Regional healthcare disparities are biases that are based on where people live. Are your patients’ treatment options being impacted and limited by their geographical location? Join us as our two experts discuss how to support broader policy issues and highlight the importance of diagnostic algorithms that have been developed with diverse input. These steps may be of value in your clinical practice to ensure all patients have equal access to care regardless of their epidemiologic, socioeconomic, or insurance circumstances.
Host: Joshua Sharfstein, MD
Host: Stephanie Desmon
Guest: Dorry Segev, MD, PhD
With organ transplants on pause in the US to free up needed hospital resources, Americans with kidney failure are forced to assume the risks of going to crowded dialysis centers three times a week. Kidney transplant surgeon Dr. Dorry Segev talks with Stephanie Desmon about how the organ transplant community can rethink ways to resume transplants, assess which patients might fare better with risky transplants, and if COVID-19 patients can be organ donors.
Published April 28, 2020
Host: Paul Doghramji, MD
Guest: Maria Escolar, MD, MS
Adrenoleukodystrophy (ALD) is a rare genetic disorder that when left untreated, can have severe and even fatal consequences. Here to review the available treatment options for these patients is Dr. Maria Escolar, the Director of the Program for the Study of Neurodevelopment in Rare Disorders and a Professor of Pediatrics at the University of Pittsburgh School of Medicine.
Host: Mario R. Nacinovich, Jr., MSc
Guest: Paul Orchard, MD
Although it only affects about one in 18,000 people, the impacts of adrenoleukodystrophy cannot be underestimated. That’s why Dr. Paul Orchard joins Mario Nacinovich to talk about this rare—and fatal—genetic disease, why it’s often underdiagnosed and confused with other conditions, and how we can treat it once we’ve reached an accurate diagnosis.
Host: Brian P. McDonough, MD, FAAFP
Dr. Brian McDonough is joined by Dr. Mark Zucker, Director of the Cardiothoracic Transplantation Program at RWJBH/Newark Beth Israel Medical Center, and his HCM patient and founder of the Hypertrophic Cardiomyopathy Association, Lisa Salberg, to discuss her inspiring story and the importance of early diagnosis.
Host: Maurice Pickard, MD
Guest: Bob Mitchell
Quite suddenly, Bob Mitchell became very sick. He would endure three near-fatal episodes of ventricular tachycardia due to a heart muscle comprised of 54% scar tissue, as well as heart surgeries, two harrowing months of waiting on the transplant list for a new heart on life-supporting IV drips (during which time a malignant tumor was detected in his kidney), partial nephrectomy surgery to remove the cancer, another month of waiting, a 12-hour heart and kidney transplant surgery, and 100 days on life support in four different hospitals.
Host Dr. Maurice Pickard talks with novelist Bob Mitchell, author of Time for a Heart-to-Heart: Reflections on Life in the Face of Death about his inspiring story of the triumph of hope in the face of the direst of circumstances.
Host: Shira Johnson, MD
For the first time, Penn Medicine surgeons were able to complete a bilateral hand transplant on a child. The surgical team successfully transplanted donor hands and forearms onto 8-year-old Zion Harvey who, several years earlier, had undergone amputation of his hands and feet and a kidney transplant following a serious infection.
Host Dr. Shira Johnson sits down with Dr. Scott Levin, who led the surgical team and is Chairman of the Department of Orthopaedic Surgery at Penn Medicine. They discuss this remarkable, groundbreaking surgery.
Host: Shira Johnson, MD
Guest: Joseph M. Serletti MD
Reconstructive microsurgery, where specialized operating microscopes and precision instrumentation are utilized to perform intricate operations in very small fields, is a rapidly evolving specialty. Dr. Joseph Serletti, Chief of the Division of Plastic Surgery at the University of Pennsylvania Perelman School of Medicine, oversees the largest reconstructive microsurgery program by volume in the country, performing over 700 free tissue transfers for breast, head & neck, and extremity reconstructions. Dr. Serletti joins host Dr. Ashira Johnson discusses the nuances of these complex procedures, as well as updates on the next horizons in reconstructive microsurgery such as facial and hand tranplants and replants.
Host: Barnett Mennen, MD
Guest: Maarouf Hoteit, MD
Hepatocellular carcinoma is one of the top ten causes of cancer death in the United States, and is the most rapidly increasing cause of cancer death in men. What's more, incidence rates are on the rise. For these reasons, understanding the nuances of early liver cancer detection, and treating underlying liver diseases prior to cancer development, have been more urgently needed.
Joining Dr. Barry Mennen to discuss diagnostic, medical, and surgical priorities for managing hepatocellular carcinoma is Dr. Maarouf Hoteit, Assistant Professor of Clinical Medicine, Director of the Multidisciplinary Liver Tumor Clinic, and Program Director of the Transplant Hepatology Fellowship at the University of Pennsylvania Perelman School of Medicine.
Host: Jennifer Caudle, DO
Guest: Christian A. Bermudez, MD
Christian A. Bermudez, MD is the Surgical Director of Lung Transplantation and ECMO, Director of Thoracic Transplantation, and Associate Professor of Surgery at the Hospital of the University of Pennsylvania. Dr. Bermudez discusses current technologies used in lung transplantation, including mechanical support as a bridge to oxygenation during the procedures themselves. He also reviews the role of Extracorporeal Membrane Oxygenation (ECMO) in lung transplantation.
CDC's Dr. Phoebe Thorpe speaks with Dr. Sherif Zaki about the important work being done to further reduce the risk of unusual transplant-associated infections.
Ensuring that organs are safe requires:
- Involvement by many disciplines including: pathologists, epidemiologists, clinicians, and others
- Global collaboration between federal and state agencies as well as academic institutions
- Continued focus on improving regulations and screening procedures
Guest: Paul R. Helft, MD
Host: Aaron Carroll, MD
Guest: A. Joseph Tector, MD, PhD
One of the most pressing problems in transplant medicine is the shortage of available organ donors to keep up with high demand. What are the ethical considerations of solving the liver shortage problem with xenotransplantation? Host Dr. Aaron Carroll welcomes Drs. Tector and Helft for the second part in a discussion of xenotransplantation. Dr. Joseph Tector directs the section of transplant surgery's xenotransplantation research program at Indiana University Health. Dr. Paul Helft is director of the Charles Warren Fairbanks Center for Medical Ethics at Indiana University Health, and is a member of the IU Health Ethics Committee and co-chair of the IU Health Ethics Consultation Subcommittee.
Guest: Paul R. Helft, MD
Host: Aaron Carroll, MD
Guest: A. Joseph Tector, MD, PhD
The necessity for transplantation of living cells from other species, or xenotransplantation, may arise when human donors are not available, a bridge organ is needed, or animal cells can provide a unique benefit to patients. Host Dr. Aaron Carroll's guests are xenotransplantation experts Dr. Paul Helft, director of the Charles Warren Fairbanks Center for Medical Ethics at Indiana University Health, and Dr. Joseph Tector, chief of transplant surgery at Indiana University School of Medicine. What is the history of xenotransplantation? What donor species are currently the subject of the most promising research in terms of solid organ transplantation and overcoming immunologic barriers and infection? Find out which patients might be the first to benefit.
Guest: Audrey A. Krause, PhD
Host: Aaron Carroll, MD
Psychosocial issues arise before, during and after organ transplantation. To address these issues proactively and comprehensively, many transplant centers incorporate a psychological assessment as part of the protocol to evaluate patients for transplantation. What are the psychological criteria for inclusion or exclusion for listing? And how are psychosocial issues managed for patients both before and after surgery? Host Dr. Aaron Carroll's guest is Dr. Audrey Krause, assistant professor of clinical psychology at the Indiana University School of Medicine.
Host: Aaron Carroll, MD
Guest: John M Reynolds, MD
Which patients are good candidates for lung transplantation? How sick does a patient need to be to qualify? How does the transplant allocation system work? Host Dr. Aaron Caroll welcomes Dr. John M. Reynolds, medical director of Indiana University Health Lung Transplant Program, to discuss these questions and other considerations regarding potential lung transplant candidates, including the lung allocation score system, and how to assess the optimal time frame to transplant patients for the best chances to improve overall quality of life.
Host: Aaron Carroll, MD
Guest: Rodrigo M. Vianna, MD
Multivisceral transplant entails the transplant of nearly all the abdominal organs, with the exception of the kidneys. It is a highly unusual procedure, with only about 30-40 such surgeries occurring per year in the United States, compared to thousands of liver transplants performed annually, in only about seven transplant centers in the United States. Host Dr. Aaron Carroll welcomes Dr. Rodrigo Vianna, director of intestinal and multivisceral transplant at Indiana University Health, to discuss when multivisceral transplant can be used to treat patients with rare tumors, such as neuroendorcrine or desmoid tumors.
Host: Aaron Carroll, MD
Guest: Patricia Scott, PhD
Transplantation offers patients a new lease on life, but the process of waiting before and recovering after a transplant can take their toll. Host Dr. Aaron Carroll is joined by Dr. Patricia Scott, who studies occupational role transitions throughout the liver transplantation process at Indiana University, to discusses the challenges patients face and their quality of life before and after transplantation. Dr. Scott also talks about how healthcare providers can help foster a better quality of life for patients surrounding transplantation.
Host: Lee Freedman, MD
Guest: Patricia Ford, MD
Patients may choose bloodless medicine for either medical or ethical reasons. How safe and effective are bloodless procedures, compared to more traditional approaches? Dr. Patricia Ford, clinical associate professor of medicine, medical director of the Center for Bloodless Medicine and Surgery and director of the peripheral stem cell program at Penn Medicine, says that while bloodless medicine began as a way to meet the medical needs of Jehovah's Witnesses patients, the science also has broader implications. As many as 30% of blood transfusions may be unnecessary. What alternatives and strategies can healthcare providers use to ensure best patient blood management, and perhaps reduce the need for blood transfusions? Furthermore, what are the specific implications of bloodless medicine for stem cell transplants in particular? Dr. Lee Freedman hosts.
Produced in Cooperation with
Guest: William Goggins, MD
Host: Aaron Carroll, MD
Some patients needing kidney transplants have to wait much longer than others because of their sensitization to human leukocyte antigen (HLA). How are new desensitization protocols opening the door to transplantation for these patients who were previously ineligible? Host Dr. Aaron Carroll talks to Dr. William Goggins, kidney transplant surgical director at Indiana University Health.
Host: Aaron Carroll, MD
Guest: Mary Maluccio, MD, MPH
While the incidence of many types of cancer in the United States has decreased in recent years, the incidence of hepatocellular carcinoma, secondary to either hepatitis B or cirrhosis, has been on the rise. And, of the treatment options including resection, ablation and transplantation, what tumor characteristics determine treatment and which patients might benefit most from liver transplant? Dr. Mary Maluccio, director of the liver oncology program at Indiana University Health, discusses the advantages of transplant, the length of time that patients generally wait to receive a donor liver and the criteria for donor organs. Hosted by Dr. Aaron Carroll.
Guest: Jonathan Fridell, MD
Host: Aaron Carroll, MD
Although most patients with type 1 diabetes are able to rely on insulin to effectively manage their condition, sometimes insulin is not enough. When should these patients consider pancreas and/or kidney transplant? Dr. Jonathan Fridell, surgical director of the pancreas transplant program at Indiana University Health, talks with host Dr. Aaron Carroll about the benefits of separate or simultaneous pancreas and kidney transplantation, and says that such transplants can effectively cure patients of their type 1 diabetes. Of course, not every patient with type 1 diabetes is an appropriate candidate for transplant, and sometimes the side effects of immunosuppresive drugs are serious. What are the factors that influence a patient's eligibility for pancreas and kidney transplant? If a patient already has a kidney transplant, are there any disadvantages to getting a pancreas transplant, since these patients are already on immunosuppressive medications?
Guest: Thomas C. Wozniak, MD
Host: Aaron Carroll, MD
Currently, 3 to 5 million people per year suffer from heart failure in the United States; one-third of these patients suffer from Class III or Class IV heart disease. Host Dr. Aaron Carroll welcomes Dr. Thomas Wozniak, surgical director of the Indiana University Health Thoracic Transplant Program. Dr. Thomas discusses the advanced heart failure patient, and who is a candidate for ventricular assist device (VAD) therapy and cardiac transplantation and considerations about timing.
Guest: Paul Kwo, MD
Host: Aaron Carroll, MD
Approximately three million people in the US have hepatitis C. In some cases, hepatitis C can be completely cured. However, many with the condition may be asymptomatic for decades and thus are not diagnosed until the disease has progressed into later stages. This is problematic, because when hepatitis C advances, it may cause scarring of the liver. When should liver transplant be considered for these patients? And what is the rate of recurrence and necessity for re-transplantation? Dr. Paul Kwo, medical director of the adult liver transplant program at Indiana University Health, discusses treatment options for patients with various stages of hepatitis C, as well as the evaluation process for those with advanced hepatitis C who are liver transplant candidates. Dr. Aaron Carroll hosts.
Guest: Tim Taber, MD
Host: Aaron Carroll, MD
Patients needing transplantation have two options--receiving an organ from a deceased donor or a living donor. In which cases might living organ donation be a viable option, and what are the advantages to this procedure? Dr. Tim Taber, medical director of the kidney and pancreas transplant program at Indiana University Health, discusses the issue of organ shortages, how organs are allocated and the process of living organ donation. Dr. Aaron Carroll hosts.
Guest: Linda Raynes Mahony, MS, RD, CDE
Host: Steven Edelman, MD
Fifty percent of patients living with diabetes will require some sort of renal replacement therapy. What percent will go on to renal transplantation and what are the recommendations for the management of these patients? Join host Dr. Steven Edelman and his guest, transplant dietitian at the University of California, San Diego, Linda Raynes Mahony, as they discuss medications, nutrition and overall management of renal transplant patients.
Guest: Denton Cooley, MD
Host: Martin Samuels, MD
In April, 1969, the first artificial heart was implanted as a bridge until a human heart could be implanted. It was hailed as a milestone medical treatment, but the ethical implications were widely debated as well. The heart surgeon who performed this ground-breaking surgery, in addition to devising pioneering surgical treatments for infants and children and founding the Texas Heart Institute, Dr. Denton Cooley, is Dr. Martin Samuels' guest.
Guest: Thomas Starzl, MD, PhD
Host: Martin Samuels, MD
Now in his 80s, Dr. Thomas E. Starzl is actively pursing his latest research interests and gives no indication of slowing down. He is widely known as the father of transplantation. But what is not widely known is that his early work was in neurophysiology. What made him choose surgery? What was it like when he was doing his pioneering transplantation work? What is he researching now? Host Dr. Martin Samuels and Dr. Thomas Starzl discuss.
Guest: Stuart Finder, PhD
Host: Maurice Pickard, MD
The face transplant is a relatively new, experimental procedure still in its early stages. This operation is comparable to a hand transplant, in that the patient’s quality of life may be improved with the procedure, but the condition is not immediately life-threatening. How can physicians discuss the risk-benefit ratio of this procedure with potential face transplant patients? What happens if the procedure fails? How does a multidisciplinary team prepare a patient considering this procedure, from the psychological to the financial aspects? Tune in to hear Dr. Stuart Finder, director of the center for healthcare ethics at Cedars-Sinai Medical Center, discuss these and other ethical considerations of the face transplant procedure with host Dr. Maurice Pickard.
In an issue of the Journal, Boucek et al. reported on three cases of heart transplantation from infants who were pronounced dead on the basis of cardiac criteria. Moderator Atul Gawande, of Harvard Medical School; George Annas, of the Boston University School of Public Health; Arthur Caplan, of the University of Pennsylvania; and Robert Truog, of Harvard Medical School discuss key ethical aspects of organ donation after cardiac death.
Guest: Joseph Murray, MD
Host: Martin Samuels, MD
Nobel Prize winner Dr. Joseph E. Murray discusses performing the first successful human kidney transplant, the value of teamwork, the future of the physician-scientist, and the patient side of the equation, in this far-ranging conversation led by host Dr. Martin Samuels.
Guest: Paolo Macchiarini, MD, PhD
Host: Lee Freedman, MD
Recently, scientists were able to engineer for the first time a trachea developed from a patient's own stem cells, wherein a donor's trachea was lined with the patient's stem cells to prevent transplant rejection. Immunosuppressive therapy was not necessary, and the patient remains in good condition months after the surgery. Dr. Paolo Macchiarini, head of thoracic surgery at Hospital Clinic in Barcelona, Spain, delves into the details of this breakthrough surgery with host Dr. Lee Freedman.
Guest: Dennis A. Steindler, PhD
Host: Leslie P. Lundt, MD
What are the barriers in science that keep us from reaching the lofty goal of limb and organ regeneration? Host Dr. Leslie Lundt is joined by Dr. Dennis Steindler, the Joseph J. Bagnor/Shands Professor of Medical Research and the executive director of the McKnight Brain Institute at the University of Florida, to learn about the work of the Regeneration Project, a partnership of the McKnight Brain Institute and the Program in Stem Cell and Regenerative Medicine at the University of Florida. Find out how the study of salamanders could lead us to the next steps in regeneration.
Guest: Arthur Matas, MD
Host: Mark Nolan Hill, MD
Our system for procuring organs in the United States is based on altruism, but unfortunately, this approach continues to leave supplies short of demand, creating a shortage in transplantable organs that causes unnecessary deaths. As a means to meet the demands in other countries around the world, various forms of payment have been considered, and some are in use today. Dr. Arthur Matas, professor of surgery and director of the renal transplant service at the University of Minnesota Medical School, explains how the concept of financial incentives for organ donation could be received by the American populace and within the medical community. Toward this end, how would a large-scale clinical trial, yet to be conducted on this model, help us to evaluate our options in the United States? Dr. Mark Nolan Hill hosts.
Guest: Arthur Matas, MD
Host: Mark Nolan Hill, MD
Since the mid-1970s, all 50 states have afforded citizens an opportunity to donate their organs for transplantation after death, either by signing the back of their drivers' license or through an organ donation card. Yet our supply of organs remains woefully short of demand for transplantation. What if we took steps, as many countries around the world have, to make organ donation near-mandatory? Dr. Mark Nolan Hill welcomes Dr. Arthur Matas, professor of surgery and director of the renal transplant service at the University of Minnesota Medical School, to weigh the effects of a ‘presumed consent' program for organ donation. In which countries has this practice brought a notable increase in organ donation, and what might be the pitfalls for such a program in the United States?
Guest: Mark Boucek, MD
Host: Mark Nolan Hill, MD
For years, we have performed pediatric heart transplants following the declaration of brain death in donors. To this point, those who die of cardiovascular complications have not been considered for heart donorship. How are advances in this area forcing us to reconsider the prospect of a heart transplant after cardiocirculatory death? Host Dr. Mark Nolan Hill considers the potential ramifications of this fascinating investigation with Dr. Mark Boucek, director of pediatric cardiovascular services at Joe DiMaggio Children's Hospital in Hollywood, Florida, and the lead author of research published in the New England Journal of Medicine on three cases of pediatric heart transplantation after cardiocirculatory death. Does this successful restarting of the heart in transplant recipients suggest that the donor's heart stoppage was not irreversible?
Guest: Armand Antommaria, MD, PhD
Host: Maurice Pickard, MD
Donation of the heart after asystole leads to questions about the point at which death is irreversible. Dr. Armand Antommaria, assistant professor in the division of pediatric inpatient medicine and an adjunct assistant professor in the division of medical ethics and humanities at the University of Utah School of Medicine, discusses the ways that pediatric cardiac transplant surgery may be pushing controversial organ-retrieval strategy beyond acceptable legal, moral, and ethical boundaries. Hosted by Dr. Maurice Pickard.
Guest: Valluvan Jeevanandam, MD
Host: Mark Nolan Hill, MD
The Chicago metropolitan area is home to five adult heart transplant centers, equal to Philadelphia for the most in one city in the United States. Some say this figure is a tribute to the determination of Chicago's hospitals to collectively become a national leader in heart transplantation. Others believe this is a serious strategic gaffe. What are the key policy questions at hand? Dr. Valluvan Jeevanandam, professor of surgery and chief of cardiothoracic surgery at the University of Chicago Pritzker School of Medicine, talks with host Dr. Mark Nolan Hill about the process of developing a transplant facility at a medical institution.
Guest: Valluvan Jeevanandam, MD
Host: Mark Nolan Hill, MD
Heart transplants are among the most complex procedures in medicine. Without performing transplants on a consistent basis, it is argued that transplant teams may not be able to maintain the utmost level of precision requisite for care. In cities like Chicago, which has five transplant centers, are there factors preventing one or more of these hospitals from achieving the highest standard of care? Is there an efficient way to remedy the prospective dilemma for Chicago and other urban centers in a similar situation? Host Dr. Mark Nolan Hill considers the potential value of redundancy among these programs, and whether there is an ideal number of transplant centers for a major metropolitan area, with Dr. Valluvan Jeevanandam, professor of surgery and chief of cardiothoracic surgery at the University of Chicago Pritzker School of Medicine.
Guest: Gary Becker, PhD
Host: Maurice Pickard, MD
Dr. Gary Becker, Nobel laureate and professor of economics and sociology at the University of Chicago, joins host Dr. Maurie Pickard to discuss the connection between the gap in supply and demand in the economic market and the same gap in the organ transplant market. Dr. Becker presents a solution and answers the critics.
Guest: Gary Becker, PhD
Host: Maurice Pickard, MD
Nobel Prize recipient for Economic Science, Dr. Gary Becker, professor of economics and sociology at the University of Chicago, explains how monetary incentives would sufficiently increase the supply of organs for transplant surgery, eliminating the very long queues in the donor market. Undoubtedly the suffering of those on the waiting list would be significantly decreased, but are there costs that might not be immediately obvious? Join Dr. Becker and host Dr. Maurie Pickard for this fascinating discussion.
Guest: Julie Salamon
Host: Leslie P. Lundt, MD
We know graft-versus-host disease is a common complication in transplant patients. How can this also be happening at an institutional level? Julie Salamon's recent book, Hospital-Man, Woman, Birth, Death, Infinity Plus Red Tape, Bad Behavior, Money, God and Diversity on Steroids, offers a glimpse of her year-long journey through Maimonides Hospital in Brooklyn, New York. Ms. Salamon joins host Dr. Leslie Lundt to discuss the complex cross-cultural implications of 21st century American medicine.
Guest: Benjamin Hippen, MD
Host: Maurice Pickard, MD
Dr. Benjamin Hippen speaks about the Iranian system that allows an individual's kidney to be sold by the donor, whom we can also think of as the vendor. Examination has shown that the recipients are on a level playing field and there is no tourism or fraud. The responsibility for recruiting potential vendors becomes separated from the responsibility for approving the vendor's medical and surgical candidacy. But moral concerns in the US may have to be resolved in the future by a hybrid system that combines features of both systems.
Guest: Benjamin Hippen, MD
Host: Maurice Pickard, MD
Dr. Benjamin Hippen reviews the kidney transplantation policy failure in the United States. The cost is now 21 billion dollars in Medicare commitment to end-stage renal disease and 50 percent of those on the transplant waiting list will likely die before receiving an organ. This situation is getting worse by the day. Iran is the only country in the world that has no organ shortage. Is their system of legal organ "vending" worth examining?
Guest: Scott Gottlieb, MD
Host: Michael Benson, MD
What are the major differences in organ transplantation between the United States and other countries? Who pays? And who decides? Join host Dr. Michael Benson as he discusses the policy variance in organ transplantation worldwide with Dr. Scott Gottlieb. Dr. Gottlieb is an internist and resident fellow at the American Enterprise Institute, a Washington, DC, think tank, and contributing healthcare opinion writer for the Wall Street Journal.
Host: Maurice Pickard, MD
Guest: Michele Goodwin, JD
Michele Goodwin, Professor of Law at the University of Minnesota and recent author of "Black Markets: The Supply and Demand of Body Parts," joins host Dr. Maurie Pickard to discuss the transplant waiting list. How we can respond to the growing list of patients waiting for transplants. Can we fairly address the dynamics of a wait list that has one group of people such as African Americans who are more severely impacted by lack of available organs for transplant? Join us for an interesting conversation.
Guest: Michele Goodwin, JD
Host: Maurice Pickard, MD
Michele Goodwin, Professor of Law at the University of Minnesota and recent author of "Black Markets: The Supply and Demand of Body Parts," formulates a hybrid business model that includes incentives and altruism to increase the number of transplants by 40% per year. The voice of moral concern is not the only one being heard in this paradigm.
Guest: Michele Goodwin, JD
Host: Maurice Pickard, MD
Michele Goodwin, Professor of Law at the University of Minnesota and recent author of "Black Markets: The Supply and Demand of Body Parts" discusses what can be done to shorten the wait for organ transplants. Current solutions such as matching programs, solicitations and altruism still lead to poor outcomes in that 50% of patients on transplant lists die before their names are called.
Guest: Brian Kaplan, MD
Host: Lauren Streicher, MD
While freezing embryos has long been an option, many single women who hope to have a future partner, are requesting oocyte preservation rather than utilizing donor sperm. Dr. Kaplan discusses new methods of cryopreservation , current clinical recommendations and outcomes.
Guest: Bernhard Hering, MD
Host: Mark Nolan Hill, MD
Islet Cell Transplantation is a promising treatment for diabetics however, if approved there will likely be a shortage of islet cells. Dr. Bernhard Hering shares his research with host Dr. Mark Nolan Hill about the use of pig tissue for human islet transplant.
Guest: Clarisa Gracia, MD
Host: Lisa Mazzullo, MD
Dr. Gracia and Dr. Mazzullo discuss ovarian function and fertility before, during and after cancer treatments. The new ways in which we are beginning to perserve fertility provides hope for young cancer patients.
Guest: Clarisa Gracia, MD
Host: Lisa Mazzullo, MD
There are over 10 million new cancer diagnoses every year, and 5% occur in women of pre-pubescent and child-bearing ages. What impact does this have on their fertility, and what new measures are being taken before patients undergo treatment to protect the future of their fertility? Dr. Clarisa Gracia, assistant professor of obstetrics and gynecology at the University of Pennsylvania School of Medicine, joins host Dr. Lisa Mazzullo.
Guest: Robert Brown, MD
Host: Mark Nolan Hill, MD
What advice can you offer a patient awaiting a liver donation? Is there anything you can do to help them to find a living donor? Join Dr. Mark Hill in an interview with Transplant Surgeon Robert Brown MD in a discussion about the process of finding a living donor match.
Guest: Robert Brown, MD
Host: Mark Nolan Hill, MD
While there is a long list of patients awaiting organ transplants and an increase in the number of living donors, there are also many legal and ethical issues to be grappled with. In this segment, host Mark Nolan Hill, MD talks to transplant surgeon Dr. Robert Brown about legal and ethical challenges surrounding living donors.
Guest: Robert Brown, MD
Host: Mark Nolan Hill, MD
In this segment our guest, Dr. Robert Brown walks through the living organ donation process with host Dr. Mark Nolan Hill. What is the surgical procedure for the donor and recipient? Join Us.
Guest: Robert Brown, MD
Host: Mark Nolan Hill, MD
Has a patient asked you yet, your medical opinion regarding their decision to become a living donor? The number of living liver donors is growing each year. The ability to give the gift of life to another is appealing to many but what are the costs? What are the risks? What are the health requirements? Join host Mark Nolan Hill in a discussing with Dr. Robert Brown about what is involved in becoming a living liver donor.
Host: Larry Kaskel, MD
Guest: Elizabeth Tieman, MD
Work-life balance: how many of us can say we have it, let alone come close to having it? Board-certified radiologist Dr. Betsy Tieman is one healthcare professional who can say she achieved work-life balance by leaving private practice where she was working 14 hours a day to take advantage of locum tenens work, which also enabled her to train and compete in triathlons.
Guest: J. Lee Nelson, MD
Host: Michael Benson, MD
Microchimerism may have a role to play in evolving theories in transplantation biology, HIV, Alzheimer's disease and even breast cancer. Dr. Nelson discusses some cutting-edge hypotheses and strange observations in each of these fields.
Guest: Michael Millis, MD
Host: Maurice Pickard, MD
In this segment, Dr. Millis examines the ethical issues of several modern organ donation methods, including paired exchange. Referenced and discussed in this discussion is the Norwood Living Organ Donation Act passed recently, and the challenges and controversies this development has brought. The interview concludes with a critical analysis on matching donor website organizations, raising the question on whether these resources ultimately prevent a level playing field for waiting organ recipients.
Guest: Michael Millis, MD
Host: Maurice Pickard, MD
In this segment, Dr. Millis examines the use of "marginal" or "expanded" donors in the United States, and the various factors behind increasing utilization of these potential donors who would otherwise be ineligible from their own medical problems or comorbidities. The interview then transitions towards some of the ethical issues inherent in "presumed" consent, a hospital policy recently accelerating throughout much of Europe.
Guest: Michael Millis, MD
Host: Maurice Pickard, MD
In this segment, Dr. Millis discusses his work in spurring changes within the Chinese transplant programs to institute more ethically sound transplant policies. Currently there are approximately 120 accredited transplant centers in China, a far-cry from the 500 loosely certified centers operating only a few years ago. The interview follows with a discussion on the end of "transplant tourism" and the various coercive measures exacted to make organ donors of Chinese prisoners.