AJP - Renal Physiology Podcasts: Recent Episodes
None
AJP-Renal Physiology would like to recognize an important article out this month by Kelli Sas and her colleagues entitled, HYPERGLYCEMIA IN THE ABSENCE OF CILIA ACCELERATES CYSTOGENESIS AND INDUCES RENAL DAMAGE.
Listen in as Associate editor Jennifer Sullivan and Dr. Sas discuss how hyperglycemia, in the absence of cilia, results in renal structural and functional damage and accelerates cystogenesis, suggesting that diabetes is a risk factor for the progression of polycystic kidney disease.
In October, we are highlighting a paper just published under our Renal Hemodynamics: Integrating with the Nephron and Beyond call for papers. Please listen in as associate editor Anita Layton discusses "Sex differences in ET-1 receptor expression and Ca2+ signaling in the IMCD." with authors David Pollock and Paul O'Connor.
In September, we would like to highlight a paper from our most recent chronic kidney disease and fibrosis call. Associate Editor Jennifer Sullivan and Dider Portilla of The University of Arkansas for Medical Sciences will discuss his group's recent AJP-Renal publication, "Proximal tubule PPARalpha attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction."
For our August podcast, Editor in Chief Darwin Bell will be discussing with Subhashini Bolisetty of The University of Alabama at Birmingham, their group's latest paper which looks at the effects of Mitochondria-targeted heme oxygenase-1.
On July 1, AJP-Renal welcomed our new Editor in Chief Darwin Bell along with a new associate editor team and editorial board. Please listen in as outgoing Editor in Chief, Thomas Kleyman and Dr. Bell discuss the future of AJP-Renal Physiology.
Our editor in chief elect Dr. Darwin Bell and Dr. Stuart Shankland of the University of Washington School of Medicine will be joining us for the June 2013 AJP-Renal Podcast. Tune in as they discuss their findings as to how prednisone may improve outcomes in FSGS.
Jiong Zhang, Jeffrey W. Pippin,Ronald D. Krofft,Shokichi Naito,Zhi-Hong Liu,and Stuart J. Shankland. Podocyte repopulation by renal progenitor cells following glucocorticoids treatment in experimental FSG. Am J Physiol Renal Physiol June 1, 2013 304:F1375-F1389; published ahead of print March 13, 2013, doi:10.1152/ajprenal.00020.2013
Join Associate Editor Gerald Apodaca as he hosts Dr. Simon Atkinson and Peter Corridon for our May 2013 AJP-Renal podcast. They will be discussing their method which employs hydrodynamic forces to facilitate transgene expression in rat kidneys.
Peter R. Corridon,George J. Rhodes,Ellen C. Leonard,David P. Basile,Vincent H. Gattone II,Robert L. Bacallao,and Simon J. Atkinson. A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vector. Am J Physiol Renal Physiol May 1, 2013 304:F1217-F1229; published ahead of print March 6, 2013, doi:10.1152/ajprenal.00070.2013
April showers bring May flowers and at AJP-Renal, our April podcast brings about a lively discussion between Editor in Chief Thomas Kleyman and Dr. Mark Parker of Case Western Reserve University about his and his colleagues findings using a heterologous expression system to examine the substrate specificity of the sodium bicarbonate co-transporter SLC4A4. Please listen in.....
Seong-Ki Lee,Walter F. Boron,and Mark D. Parker.Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbit. Am J Physiol Renal Physiol April 1, 2013 304:F883-F899; published ahead of print January 16, 2013, doi:10.1152/ajprenal.00612.2012
This month's podcast features Associate editor Dr. Darwin Bell and Dr. Gabriel Navar of Tulane discussing the results of activation of the Renin-Angiotensin system by low salt in rats. This paper is highlighted in the March 2013 issue of AJP-Renal.
Weijian Shao,Dale M. Seth,Minolfa C. Prieto,Hiroyuki Kobori,and L. Gabriel Navar. Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats. Am J Physiol Renal Physiol March 1, 2013 304:F505-F514; published ahead of print January 9, 2013, doi:10.1152/ajprenal.00587.2012
February's issue of AJP-Renal brings us a very interesting article by Dr. Bernardo Rodriquez-Iturbe and his group on heat shock protein 70. Join associate editor Jeffery Garvin and Dr. Rodriquez-Iturbe as they discuss it's affects on immune response.
Héctor Pons, Atilio Ferrebuz, Yasmir Quiroz, Freddy Romero-Vasquez, Gustavo Parra, Richard J. Johnson, and Bernardo Rodriguez-Iturbe. Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension. Am J Physiol Renal Physiol February 1, 2013 304:F289-F299; published ahead of print October 24, 2012, doi:10.1152/ajprenal.00517.2012
Our AJP-Renal December podcast focuses on a manuscript describing the use of Drosophila to explore the role of a specific transport protein in the genesis of kidney stones. Join Dr. Kleyman as he discusses this new model system with Dr. Michael Romero and Dr. Julian Dow.
Dr. Michael Romero Dr. Julian Dow
Taku Hirata, Pablo Cabrero, Donald S. Berkholz, Daniel P. Bondeson, Erik L. Ritman, James R. Thompson, Julian A. T. Dow, and Michael F. Romero. In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol 303: F1555-F1562; published ahead of print September 19, 2012, doi:10.1152/ajprenal.00074.2012.
Our October 2012 podcast highlights work by Dr. Kenichiro Kitamura and his colleagues at Kumamoto University Graduate School of Medical Sciences. They have recently published two papers in AJP: Renal Physiology: “In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats” and “Effect of a serine protease inhibitor on the progression of chronic renal failure.” Join Editor-in-Chief Thomas Kleyman and Dr. Kitamura as they discuss the role of serine proteases in the progressive loss of kidney function in a rat model of CKD, and in the activation of ENaC.
Kohei Uchimura, Yutaka Kakizoe, Tomoaki Onoue, Manabu Hayata, Jun Morinaga, Rika Yamazoe, Miki Ueda, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Yoshiki Sakai, Kimio Tomita, and Kenichiro Kitamura. In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats Am J Physiol Renal Physiol October 1, 2012 303:F939-F943; published ahead of print July 25, 2012, doi:10.1152/ajprenal.00705.2011
Manabu Hayata, Yutaka Kakizoe, Kohei Uchimura, Jun Morinaga, Rika Yamazoe, Teruhiko Mizumoto, Tomoaki Onoue, Miki Ueda, Naoki Shiraishi, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, and Kenichiro Kitamura.Effect of a serine protease inhibitor on the progression of chronic renal failure Am J Physiol Renal Physiol; published ahead of print July 25, 2012, doi:10.1152/ajprenal.00706.2011
For August we are highlighting a paper by Raheev Rohatgi and co-workers entitled “Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct”. Listen along as Dr. Rohatgi and Editor-in-Chief Tom Kleyman discuss the role of tubular flow in activating phospholipase A2 and excretion of PGE2, and the role of PGE2 in regulating ion transport in collecting ducts.
Daniel Flores, Yu Liu, Wen Liu, Lisa M. Satlin, and Rajeev Rohatgi. Flow induced prostaglandin E2 release regulates Na and K transport in the collecting duct. Am J Physiol Renal Physiol; published ahead of print June 13, 2012, doi:10.1152/ajprenal.00169.2012
Our July 2012 podcast highlights a paper published by Dr. Valdimir Pech and his colleagues entitled “ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism”. Join us as Editor-in-Chief Thomas Kleyman and Vladimir Pech discuss the role of electrogenic Na+ absorption in Cl- absorption, and how Dr. Pech's work contrasts with previous studies addressing Cl- absorption in the CCD.
Vladimir Pech, Monika Thumova, Young Hee Kim, Diana Agazatian, Edith Hummler, Bernard C. Rossier, Alan M. Weinstein, Masayoshi Nanami, and Susan M. Wall.ENaC inhibition stimulates Cl− secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanisn. Am J Physiol Renal Physiol July 1, 2012 303:F45-F55; published ahead of print April 11, 2012, doi:10.1152/ajprenal.00030.2012
For our June Podcast, we join associate editor Darwin Bell as he speaks with Juan Carlos Velez of The Medical University of South Carolina about his recently published paper, “Enzymatic Processing of Angiotensin Peptides by Human Glomerular Endothelial Cells”. Listen in as they discuss the processing of angiotensin by glomerular endothelial cells.
Juan Carlos Q Velez, Jessalyn L Ierardi, Alison M Bland, Thomas A. Morinelli, John M Arthur, John R. Raymond, and Michael G. Janech. Enzymatic Processing of Angiotensin Peptides by Human Glomerular Endothelial Cells . Am J Physiol Renal Physiol; published ahead of print March 28, 2012, doi:10.1152/ajprenal.00087.2012
In our newest podcast, Editor in Chief Thomas Kleyman interviews senior author and past Editor in Chief Jeff Sands along with lead author Janet Klein (Emory University) about the dual phosphorylation pathways that regulate urea transporter activity in the kidney inner medulla.
Janet D. Klein, Christopher F. Martin, Kimilia J. Kent, and Jeff M. Sands. Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct. Am J Physiol Renal Physiol May 1, 2012 302:F1098-F1103; published ahead of print February 1, 2012, doi:10.1152/ajprenal.00664.2011
Listen as Associate Editor Susan Wall and Dr. Todd Alexander discuss mechanisms of calcium absorption in the nephron and Dr. Alexander's recent publication in AJP-Renal, “THE EPITHELIAL SODIUM-PROTON EXCHANGER, NHE3, IS NECESSARY FOR RENAL AND INTESTINAL CALCIUM (RE)ABSORPTION.”
Wanling Pan,Jelena Borovac,Zachary Spicer,Joost G. Hoenderop,René J. Bindels,Gary E. Shull, Michael R. Doschak, Emmanuelle Cordat, and R. Todd Alexander.The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. Am J Physiol Renal Physiol April 15, 2012 302:F943-F956; published ahead of print September 21, 2011, doi:10.1152/ajprenal.00504.2010
In our second Podcast of March, the manuscript “The Pendrin Anion Exchanger Gene is Transcriptionally Regulated by Uroguanylin: A Novel Entero-Renal Link” is discussed by Associate Editor Susan Wall and Prof. Israel Zelikovic. Listen in as they speak on a novel enterorenal link - transcriptional regulation of the pendrin anion exchanger gene by uroguanylin via a heat shock system-dependent mechanism.
Julia Rozenfeld, Osnat Tal, Orly Kladnitsky, Lior Adler, Edna Efrati, Stephen L. Carrithers, Seth L. Alper, and Israel Zelikovic. The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link. Am J Physiol Renal Physiol March 1, 2012 302:F614-F624; published ahead of print November 30, 2011, doi:10.1152/ajprenal.00189.2011
This is the first podcast by AJP:Renal addressing the important unanswered questions remaining in renal physiology. The purpose of this series is to give students, postdocs and junior faculty access to the ideas of leaders in their field. In this podcast William Arendshorst and Christopher Wilcox will discuss the big questions remaining to be solved in the field of autoregulation of renal blood flow. They address the mechanisms involved and how they are altered in pathological states.
Join us as Jeffrey Garvin, Associate Editor of AJP:Renal, leads Edwin Jackson from The University of Pittsburgh Department of Pharmacology and Chemical Biology in a exciting discussion of his group’s latest findings. Does Adenosine influence renal sympathetic nerve stimulation in the kidney?
Edwin K. Jackson, Dongmei Cheng, Stevan P Tofovic, and Zaichuan Mi. Endogenous Adenosine Contributes to Renal Sympathetic Neurotransmission Via Postjunctional A1-Receptor-Mediated Coincident Signaling. Am J Physiol Renal Physiol; published ahead of print November 23, 2011, doi:10.1152/ajprenal.00495.2011