Healthspan: Recent Episodes
Michael Salzle
@michaelsalzle. In this episode, we discussed pathways of aging. We discuss the importance of genes, AMPK, autophagy, metformin, foods that boost AMPK, autophagy, foods that boost autophagy, spermidine,epigenetics, and cellular senescence
@michaelsalzle. In this episode we discuss nutrition 3.0. Epidemiology, clinical trials. The Mediterranean diet, the University of Wisconsin CR trial vs the NIH CR trial, carbohydrates, and protein.
IG: @michaelsalzle. In this episode, we go into the broad topic of exercise. Exercise is considered the most powerful longevity drug. We review studies that underscore the importance of exercise. We also discuss the centenarian decathlon, and take a deep dive into zone 2 training.
@michaelsalzle Metformin and it’s effect on the hallmarks of aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title
@michaelsalzle. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965502/#abstract-1title--- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
@michaelsalzle. In this episode, learn about how to keep your muscle and blood young, circadian rhythm, bifidobacterium, butyrate, akkermansia, and keeping a strong gut lining. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
@michaelsalzle--- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
@michaelsalzle. https://www.cell.com/cell/fulltext/S0092-8674(22)01570-7 a link to David Sinclair’s new paper I referenced in this episode --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
@michaelsalzle in this episode I discuss the best supplements for athletic performance, the different types of protein, creatine, inositol, Amino Acids, caffeine, etc. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app
@michaelsalzle. Learn more about obesity, weight loss, hormones, calories in vs. calories out, importance of protein in muscle sparing, and metabolic rates
@michaelsalzle. Hot and cold protocols for improving performance, recovery, and overall health. Using glaborous skin to your advantage and the role of AVA‘s, the benefits of pre-exercise cooling, negative effects of cold exposure on exercise performance and adaptation, and heat exposure/heat shock proteins for improving performance and our health.
@michaelsalzle. Exercise, sleep, and future innovations in the field of aging (CR mimetics, senolytics, young blood, and yamamaka factors)
@michaelsalzle. Biological age vs. chronological age, and the importance of making aging a disease. She also reviews the different hallmarks of aging
@michaelsalzle supplements to lower uric acid, CGM importance, and the importance of time restricted eating.
@michaelsalzle. Uric Acid and the link with Alzheimer’s disease, sleep and uric acid, and other instigators of elevated uric acid
@michaelsalzle. Uric Acid- what it is, where it comes from, and how its implicated in many diseases including HTN, diabetes, NAFLD, Alzheimer’s, and much more.
@michaelsalzle Peptide, Key nutraceuticals like Metformin and NAD, hormones, fasting, time restricted eating, and the healing powers of hot and cold
@michaelsalzle. AI diagnostics, anti aging, CAR T cell therapy, CRISPR, and the WNT signaling pathway
@michaelsalzle. Introductory episode. Why Tony Robbins is writing a book about regenerative technology, diagnostic breakthroughs, and anti aging. I also discuss the power of stem cells.
@michaelsalzle. Sleep disorders, alcohol and sleep, temperature and sleep, the dark side of sleeping pills, and sleep in healthcare
@michaelsalzle. Dreaming, Freud, the purpose of dreaming, nghtmres, ptsd, and dreaming for creativity
@michaelsalzle. Sleep for learning and memory. And sleep and it’s association with Alzheimer’s, CVD, and Cancer
@michaelsalzle. The four differences in sleep across species, sleep before birth, sleep and its possible association with ASD, childhood sleep, and sleep in midlife and old age and why it decreases so substantially
@michaelsalzle. In this episode, I cover What sleep is, what sleep isn’t, caffeine, melatonin, sleep pressure, the sleep cycle, defining and generating sleep, NREM and REM
@michaelsalzle. A quick background on genes and DNA, genes that are born dirty or act dirty, SNPs, and methylation
@michaelsalzle. In this episode I discuss the current state of nutrition. I discuss the whole food plant-based diet, the cult of animal proteins, the way of assigning value to certain foods, Dr. Campbell’s run in with animal protein, why you SHOULD incorporate meat into your diet, and finally, recommendations for our institutions when it comes to nutrition.
@michaelsalzle The simple road towards wellness and optimal health. And ways to improve your health by targeting the gut microbiome. Practical tips and tricks.
@michaelsalzle. Lessons from hunter gatherers, The role of diet and shaping a babies gut brain dialogue, new diets and how they can alter our gut microbiota, the onslaught of the north American diet, and the simple road towards wellness and optimal health.
@michaelsalzle how stress effects can be transmitted from one generation to the next, stress in the womb, microbes for a healthy start, and how our microbiome affects emotions and social behavior
@michaelsalzle The emergence of the gut microbiome, the role the microbiome plays in ASD, Parkinson’s, and Depression, the role of serotonin, microbe speak, enemas, and our immune system.
@michaelsalzle. Treatment implications of cancer. Chemoprevention, and the emerging treatments of cancer, including CTLA 4 inhibitors, PD 1 inhibitors, and CAR T.
@michaelsalzle. Warburg effect, invasion and metastasis, and cancer paradigm 3.0 (transformation, progression, and metastasis)
@michaelsalzle. Nutrition and cancer. HyperInsulinemia has been well documented as the etiology of obesity and T2DM. In this episode I describe why too much Insulin may also be the culprit of cancer as well. MTOR and nutrient sensing were also discussed as well
@michaelsalzle Exercising for longevity, feeding our longevity, preventing obesity, time restricted eating, using your DNA to your advantage, and bright horizons.
@michaelsalzle In this episode, we focus on the different hallmarks of aging as well as the TAME study, the study showing that meteformin can improve age related diseases such as CVD, diabetes, cancer, and dementia.
@michaelsalzle. The mysteries of aging, what makes superagers stay healthy, a perfect genome, centenarians interactions with their environment, good genes, why we age, theories of aging, and how caloric restriction leads to longevity
@michaelsalzle. Breathing and it’s relationship to the autonomic nervous system, tummo breathing, Wim Hof, carbon dioxide, and breathing as a pillar of health. https://m.youtube.com/watch?v=tybOi4hjZFQ liked is a guided wim hof breathing session you can practice.
@michaelsalzle. In this episode, discover the importance of lung capacity, carbon dioxide, breathing less, breathing slowly, and chewing your food. https://m.youtube.com/watch?v=TY3bIMRKil8 video link on how to mew and why it’s important.
@michaelsalzle James Nestor’s 20 day breathing experiment, human skulls, nasal cycles, and the importance of nasal breathing when it comes to erectile dysfunction, lowering BP, mood, exercise performance, regulating HR, nitric oxide production, and much more.
@michaelsalzle. weight loss boosters. In this episode, learn about intermittent fasting/ caloric restriction, the ketogenic diet, meal frequency, metabolic boosters, and the idea of negative calories
@michaelsalzle weight loss boosters. The importance of thylakoids, habiscus tea, brown adipose tissue, habit formations, staying hydrated with water, and reducing inflammation
@michaelsalzle weight loss boosters: see how the rate at which you eat and the cephalic phase of eating can play a huge role in weight loss. Also, why exercise is NOT good for weight loss, but is vital for our overall health.
@michaelsalzle Weight loss boosters. In this episode, see how weighing yourself, activating AMPK, suppressing appetite, and having a “King-Prince-Pauper” model of eating can help you with your weight loss journey.
@michaelsalzle Longevity decoded part 2. The importance of injections, mitochondrial support, rhodiola, and ways to quantify aging.
@michaelsalzle longevity decoded: ancestral wisdom and modern science to maximize health and life span
@michaelsalzle In this episode, I discuss the blue zones of Costa Rica and Greece. Additionally, I go into the 9 powerful lessons you can implement immediately in your life to improve your Healthspan, and live like the centenarians in the blue zones.
@michaelsalzle in this episode, learn about the habits and daily lifestyles of the centenarians in Okinawa, Japan and Lima Linda, California.
@michaelsalzle what the blue zones are, how the term “blue zones” came about, and the Sardinian blue zone. Learn the lifestyle components that allowed Sardinia to become an area where highest amounts centenarians live and thrive.
@michaelsalzle How the FMD can prevent Alzheimer’s, reduce inflammation, and treat autoimmune diseases
@michaelsalzle what exactly the Fasting Mimicking Diet is, and how it is used to prevent cancer, diabetes, and cardiovascular disease
@michaelsalzle Dr. Longo’s childhood in Italy, yeast research, Laron syndrome, aging genes, the five pillars of longevity, caloric restriction, diet, and exercise
@michaelsalzle senescent cells, inflammation, reprogramming our DNA, Yamanaka factors, optic nerve regeneration, and the age of innovation
@michaelsalzle what we’re learning. How CR, fasting, NAD, metformin, exercise, rapamycin, hormesis, and resveratrol can all improve YOUR Healthspan
@michaelsalzle theories of aging, information theory of aging, epigenetics, sirtuins, yeast, DNA, and much more!
@michaelsalzle How to actually treat Type 2 Diabetes with surgery, fasting, and low carbohydrate dieting
How NOT to treat type 2 diabetes. Insulin, oral hypoglycemics, low fat/ high carb diets, and exercise are not the answer to treating T2D.
Insulin Resistance, Beta cell dysfunction, Fructose, and the Metabolic syndrome connection
Diabesity, The role of insulin in energy storage, and the Insulin Resistance Overflow Phenomenon
The history of diabetes and insulin, how type 2 diabetes became an epidemic, differences between type 1 and type 2 diabetes, and the whole body effect of diabetes
mycircadianclock.org. Shift working, How circadian rhythms work, and Track and test: is your circadian code in sync?