Echo Han's Podcast: Recent Episodes
Echo Han
Generally, CHO cell line is widely used in immunotoxins production. But the problems of low expression level, low stabilization and apoptosis have long plagued scientists. Hence, relying on the outstanding academic group and profound expertise, Creative Biolabs has developed High-Exp™ platform that can promote the expression level, stability and anti-apoptosis capability of immunotoxins production.
Chicken-egg-based vaccine production remains the most effective manufacturing method available.
Guillain-Barré syndrome (GBS) is an autoimmune disease of the nervous system, which is accompanied by symmetric flaccid paralysis of the extremities, sensory abnormalities, and cranial nerve palsy. https://www.creative-biolabs.com/vaccine/vaccines-for-guillain-barre-syndrome.htm
Feline immunodeficiency virus is a lentivirus that affects cats worldwide. With our extensive experience and advanced platform, we are therefore confident in offering the best vaccine development services against feline immunodeficiency virus.
Feline leukemia virus (FeLV) is retroviral in the family Oncovirinae and is one of the most feared causes of a highly contagious and potentially fatal retroviral infection that weakens a cat's immune system.https://www.creative-biolabs.com/vaccine/feline-leukemia-virus-vaccine.htm
Egg allergy, as one of the most common food allergies encountered in pediatric practice, is also an indicator of the future development of asthma and sensitization to aeroallergens. https://www.creative-biolabs.com/vaccine/vaccines-for-egg-allergy.htm
Bovine coronaviruses (BCoVs) belong to the Coronaviridae family in the Nidovirales order which cause respiratory and enteric infections in cattle and wild ruminants.
Cytomegalovirus (CMV) is from the family of Herpesviridae. Humans and monkeys serve as natural hosts. Diseases associated with CMV include glandular fever and pneumonia.https://www.creative-biolabs.com/vaccine/cytomegalovirus-vaccines.htm
Hepatitis is a general term for liver inflammation, caused by infectious or non-infectious factors. Hepatitis B virus (HBV) infection is the main cause of morbidity and mortality.https://www.creative-biolabs.com/vaccine/hbv-vaccines.htm
Hepatitis B is an infectious liver disease that comes from hepatitis B virus infection. Acute infection may last for several weeks. If the virus stays in the body, it can cause severe chronic infections, leading to liver damage, liver cancer and death. https://www.creative-biolabs.com/vaccine/hbv-vaccines.htm
Hepatitis D (hepatitis delta) is a disease caused by the Hepatitis D Virus (HDV), a small spherical enveloped virusoid. HDV is thought to be a subviral satellite because it can propagate only in the presence of the Hepatitis B Virus (HBV). https://www.creative-biolabs.com/vaccine/hepatitis-d-virus-vaccines.htm
Allergy to cats, dogs, or other furry animals is common in society and the prevalence of sensitization to pets has increased. Although the best treatment is avoidance, it is often difficult to achieve as well as not being well accepted by the patients. Therefore, new methods are urgently needed. Vaccines can provide disease-specific causative treatment by inducing tolerance to allergens and preventing the progression of allergic diseases, and play an increasingly important role in the prevention and control of allergic diseases.https://www.creative-biolabs.com/vaccine/vaccines-for-furry-animals-allergy.htm
Allergic diseases are prevalent worldwide. Allergen Immunotherapy (AIT) is a current treatment for allergic diseases, leading to modification of the natural course of the disease. Vaccine-based immunotherapy is considered to be a more effective, convenient, and safer option with promising advances in recent years.https://www.creative-biolabs.com/vaccine/allergic-diseases-vaccines.htm
Canine distemper virus is a very effective prophylactic disease that causes a large number of canine deaths each year, leading to significant economic losses. Therefore, in addition to good surveillance programs, the most important thing is to develop and produce efficient vaccines to control the disease.
https://www.creative-biolabs.com/vaccine/vaccines-for-canine-distemper-virus.htm
Taking advantage of animal and immunologic studies that defined optimal conditions for BCG response, urologists have developed BCG into the most effective treatment currently available in the treatment of aggressive superficial bladder cancer. https://www.creative-biolabs.com/vaccine/bcg-vaccines-for-cancer.htm
Bacterial diseases can be prevented by using vaccination that induce active immunity. Active immunity can be induced by vaccines prepared from bacteria or their products. Table 1 presents a summary of the types of current bacterial vaccines.
https://www.creative-biolabs.com/vaccine/bacterial-vaccines.htm
Scientists have adopted many approaches to design vaccines against microbes based on basic information about microbes, such as how they infect cells and the immune system's response to them. The two traditional types of vaccines, live attenuated and inactivated/killed vaccines, constitute the vast majority of vaccines in use at present. https://www.creative-biolabs.com/vaccine/live-attenuated-and-killed-vaccine-design.htm
Bovine coronaviruses (BCoVs) belong to the Coronaviridae family in the Nidovirales order which cause respiratory and enteric infections in cattle and wild ruminants. BCoV is a widely distributed pathogen that infects the upper and lower respiratory tract and digestive organs, causes neonatal calf diarrhea, bloody diarrhea in adult cattle (winter dysentery), and respiratory symptoms, including shipping fever in feedlot cattle. It is shed in both feces and nasal secretions and also infects the lung. It is a less frequent but nonetheless important disease in calves and deserves more attention than it has received in the past. Decreases in milk production in dairy cows with BCoV can result in serious economic losses.
https://www.creative-biolabs.com/vaccine/bovine-coronavirus-vaccines.htm
Chicken anemia virus (CAV), a genus of Gyrovirus, belonging to the Circoviridae family, is distributed worldwide and poses a serious economic threat to broiler and specific pathogen-free (SPF) egg production industries. CAV causes damage to the hematopoietic and lymphocyte tissues in the young chickens, leading to anemia, immunosuppression and systemic lymphadenopathy. Thymus atrophy and fat to yellow to pink bone marrow are the most consistent and characteristic lesions in CAV-infected chickens, respectively. CAV is transmitted through contaminated feathers and induces apoptosis in thymocytes and myeloid progenitor cells of young chickens. Chicken is the only recognized natural host, but serological surveys indicate that the disease is common in poultry and wild birds.
https://www.creative-biolabs.com/vaccine/vaccines-for-chicken-anemia-virus.htm
Type 5 adenovirus, belonging to species C adenoviruses, is a linear double-stranded DNA virus with a diameter of about 80-120 nm. It can rapidly infect mitotic and non-mitotic cells. After binding to cell surface receptors, it enters the cells through endocytosis, gathers near the nuclear pore, and releases the DNA of adenovirus into the nucleus after infection and starts protein expression. By modifying wild adenovirus, preserving the packaged signal sequence and removing the coding sequence of the viral protein, it can not only increase the loading capacity of foreign genes but also reduce the cytotoxicity and immune response of the body, thus obtaining a more secure gene import system.https://www.creative-biolabs.com/vaccine/adenovirus-type-5-vaccine.htm
Advances in recombinant DNA technology, genomics and immunology have greatly affected the vaccine development process.https://www.creative-biolabs.com/vaccine/adenovirus-ad-as-vaccine-vectors.htm
mRNA secondary structure prediction services using in silico methods to get new insights in mRNA functional characterization.https://mrna.creative-biolabs.com/in-silico-mrna-structure-prediction.htm
A variety of methods to comprehensively define RNA-protein interactions.https://mrna.creative-biolabs.com/rna-protein-interactions-analysis.htm
Comprehensive solutions for mRNA-based reprogramming which has proven to be a non-viral, non-integrating method for reliable, safe, and efficient generation of iPSC cell lines.
A range of services targeting mRNA therapeutics according to customers' detailed requirements. https://mrna.creative-biolabs.com/one-stop-mrna-therapeutics-development.htm
A series of custom mRNA stability test services
https://mrna.creative-biolabs.com/custom-mrna-stability-test-service.htm