The Joe Cohen Show: Recent Episodes
SelfDecode
Biohacker and SelfDecode founder Joe Cohen is not afraid to step on people’s toes. Join him each week as he shares his 15+ years of experience in biohacking and talks to world-class health experts about the latest technology, supplements, genetic research, and resources for biohacking your body and brain to achieve optimal performance. Each episode dives deep into new strategies to hack longevity, healthspan, cognitive function, diet, physical and mental performance, and more. Subscribe to The Joe Cohen Show and never miss a new episode.
In this episode, Joe interviews Dr. Andrew Ahn, an internal medicine physician and expert in physiological signal analysis.
The central topic of discussion is Heart Rate Variability (HRV). Dr. Ahn describes various measures of HRV, including time-domain, frequency-domain, and nonlinear analysis. He shares insights into personal HRV tracking and the lifestyle factors that influence it, such as exercise, sleep, and stress.
The conversation delves into the effectiveness of wearable devices for HRV measurement and explores breathing techniques that can improve HRV.
Additionally, Joe and Dr. Ahn discuss the role of genetics in HRV and the potential benefits and challenges of personalized health optimization through data-driven approaches.
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In this episode, Joe dives deep into the world of hair loss and hair growth treatments with Dr. Alan Bauman, a leading hair restoration physician.
With over 33,000 patients treated and 12,000 hair transplant procedures performed, Dr. Bauman shares his expertise on various treatments like PRP, FUE, Regenera, and even microneedling.
The discussion covers the effectiveness and applications of these therapies, including the potential and limitations of topical treatments like minoxidil and finasteride.
They also explore the impact of nutrition, lifestyle, and newer regenerative medicine techniques on maintaining and enhancing hair growth.
Joe brings his personal experiences and research into the conversation, seeking clarifications and insights from Dr. Bauman on how to optimize hair health.
Timestamps:
(00:00) - Introduction
(01:27) - Understanding PRP for Hair Loss
(09:02) - Comparing Hair Loss Treatments: PRP, Minoxidil, and More
(16:27) - Combining Treatments for Optimal Results
(23:27) - The Role of Genetics and Mitochondrial Function in Hair Loss
(26:43) - The Importance of Quality in Hair Growth Devices
(33:05) - Topical Finasteride: Efficacy and Usage
(40:16) - Microneedling: Benefits and Misconceptions
(45:07) - Scalp Massaging and Therapeutic Treatments
(47:00) - Ketoconazole Shampoo: Pros and Cons
(50:28) - Essential Oils and Hair Loss
(56:41) - Nutritional Factors in Hair Health
(01:03:16) - Future of Hair Loss Treatments
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In this third and final part of our series with Elizma Lambert, we dive deep into the world of biohacking, exploring the latest technology, supplements, and research. Join us as Elizma Lambert shares her expertise on optimizing both body and brain health, providing actionable tips and strategies for achieving peak performance.
In this episode, you'll discover:
- The most effective biohacks for enhancing mental clarity and physical vitality.
- How to personalize your health regimen for maximum results.
- Cutting-edge research and resources for staying ahead in the health optimization game.
- Practical advice on integrating these biohacks into your daily routine.
Whether you're a seasoned biohacker or just beginning your health optimization journey, this episode is packed with valuable insights and tips that you won't want to miss.
Tune in and take the next step toward optimizing your health with the expert guidance of Elizma Lambert.
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This is the second episode of a three-part series with Elizma Lambert, where we delve into the world of the Organic Acids Test (OAT) and its crucial role in optimizing health.
In this episode, Elizma explores an array of biochemical markers, including yeast and fungal indicators, bacterial markers, oxalate metabolites, Candida overgrowth, thyroid function, and mitochondrial efficiency.
Lambert explains how these markers are integral to identifying gut dysbiosis, assessing mitochondrial performance, achieving holistic biochemical balance, and so much more.
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This is the first episode of a three-part series with Elizma Lambert, where we delve into the world of the Organic Acids Test (OAT) and its crucial role in optimizing health.
In this episode, we get started on our analysis of Organic Acids Test (OAT) and its essential role in naturopathic medicine and precision health.
Elizma Lambert, a seasoned expert with over 20 years of experience, discusses the legitimacy and applications of functional health tests, especially the OAT test.
First, we specifically look at fungal infections like Candida, and look at how these tests diagnose complex conditions by examining the intricate relationships with symptoms and signals.
We'll explore the benefits of a holistic approach to health, moving beyond quick fixes to address genetic predispositions through multi-dimensional health strategies.
In this episode, we dive deep into the world of precision health with Dr. Michael Snyder, a renowned professor of genetics at Stanford University and the chair of the genetics department.
Join us as Dr. Snyder shares his groundbreaking insights on the latest advancements in precision medicine, biohacking, and personalized healthcare.
Discover how cutting-edge technology, supplements, and genetic research can optimize your longevity and overall wellness.
Tune in to learn how you can leverage precision medicine to enhance your longevity and improve your health. Don't miss out on the transformative potential of these innovations to help you live a longer, healthier life.
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In this episode, Joe speaks with Jean Fallacara, a multifaceted entrepreneur, neuroscientist, and calisthenics enthusiast.
Jean shares insights on how he maintains peak performance through biohacking, focusing on supplements, exercise routines, and meditation practices.
Joe and Jean dive deep into the realms of precision health, genetic testing, and maintaining a balanced, enjoyable lifestyle while pursuing optimal health.
Tune in for an engaging discussion on fitness tips, the importance of diet, and how to transform your health regimen!
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Timestamps:
(0:00) - Introduction
(19:44) - Jean's top supplements
(30:55) - Jean's diet
(35:41) - Mindset hacks
In this episode, Joe dives into the complex world of proline supplementation.
He discusses the impacts proline has on collagen synthesis, aiming for improved skin health, enhanced wound healing, and better exercise recovery.
However, the journey took an unexpected turn as Joe explains the biomechanics behind why he experienced several side effects such as anxiety, restlessness, and hypochondriac behaviors.
Throughout the episode, Joe explores:
- The intended benefits of proline for collagen synthesis and recovery
- The biochemical interaction of proline with lysine and vitamin C as per the Linus Pauling protocol
- The severe side effects experienced due to high doses of proline and the genetic predisposition affecting glutamate metabolism
- Strategies attempted to mitigate these effects
Join Joe as he unpacks the lessons learned from his proline supplementation experiment, shedding light on the potential risks and the importance of understanding one's genetic makeup before undertaking such regimens.
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Join Joe as he takes a closer look at saffron, a spice revered not just for its flavor but for its impressive health benefits.
In this deep dive, Joe explores how saffron could potentially outshine caffeine in enhancing mental clarity and focus.
This episode goes in-depth on how saffron impacts various aspects of health, from improving sleep quality to reducing gut inflammation and boosting immune function.
Discover the comprehensive effects of saffron on:
- Mental Focus: How saffron compares to caffeine in enhancing cognitive performance.
- Sleep Quality: The role of saffron in promoting restful sleep and adjusting sleep cycles.
- Gut Health & Immunity: Insights into saffron’s anti-inflammatory properties and its implications for gut health and immune system support.
- Exercise Recovery: Exploring the potential benefits of saffron in reducing muscle soreness and speeding up recovery times.
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Join Joe as he delves into his journey with MSM (Methyl Sulfonyl Methane) supplementation, a key to detoxing the body and enhancing recovery.
In this episode, Joe discusses:
- The Impact of Heavy Metals on Health: Understanding the dangers of heavy metals and the importance of detoxing them from our bodies.
- MSM as a Detox & Methylation Aid: How MSM supplementation helps clear heavy metals and play a vital role in methylation.
- Recovery and Resilience Through MSM: How MSM aids in the recovery of tendon and joint injuries, contributing to better exercise outcomes.
- Combining Sulfur Sources for Optimal Detox: Strategies in integrating MSM with other sulfur sources.
- Enhanced Health Markers: Insights into how MSM positively influences key health markers like homocysteine, DHEA sulfate, ALT, and HSCRP.
Discover the powerful role of MSM in detoxing heavy metals and enhancing physical recovery.
Tune in to learn how this supplement could revolutionize your approach to health and detoxification.
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Buy Jo’s Resistant Starch on Amazon
Join Joe as he explores the powerful benefits of resistant starch as a natural alternative to Ozempic.
In this episode, Joe dives into how resistant starch not only supports weight management and cognitive function but also promotes gut health—all without the side effects associated with pharmaceutical options like Ozempic.
Joe discusses:
- Resistant Starch for Health: How this natural supplement enhances the production of butyrate, GLP-1, and how these play significant roles in weight loss, muscle growth, and overall health improvement.
- Cognitive and Mood Enhancement: Insights into how increasing BDNF levels through butyrate production can boost cognitive functions and mood.
- Comparison with Ozempic: Joe compares the effects and side effects of resistant starch with Ozempic, providing a detailed analysis based on his personal experiences and scientific research.
- Practical Advice on Dosage: Detailing the specific dosage of resistant starch used in a recent study published in Nature in 2024, which demonstrated substantial benefits in weight management.
Tune in to learn why resistant starch might be the key to achieving your health goals naturally, making it a foundational supplement for enhancing immune function, preventing chronic diseases, and improving cognitive health.
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In this episode, Joe has an in-depth conversation with Dr. Rita Marie, a licensed doctor of chiropractic and the founder of the Institute of Nutritional Endocrinology, about the importance of personalized healthcare in addressing insulin, thyroid, adrenal, and digestive imbalances through the integration of genetics and lifestyle changes.
Dr. Rita Marie discusses her approach to helping patients by not only looking at conventional lab tests but also incorporating genetics and lifestyle factors such as diet, sleep, and stress management to create a comprehensive health strategy.
She emphasizes the necessity of moving beyond one-size-fits-all solutions to tackle health challenges, the motivational power of understanding one's genetic predispositions, and the significance of practitioners being curious and knowledgeable about nutritional biochemistry and genetics.
Additionally, the conversation delves into the necessity of optimizing health before issues become irreversible and highlights some of the common markers and supplements considered in Dr. Rita Marie's practice.
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If you’re a health practitioner, visit inemethod.com
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Visit https://drritamarie.com/
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In this episode, Joe dives deep into the effects of megadosing AKG (Alpha Ketoglutarate), a crucial supplement in metabolic pathways and its implications for longevity. Discover the risks and rewards as Joe recounts increasing his AKG intake to 15 times the standard dosage, leading to notable side effects such as enhanced anxiety and sleep issues.
Joe meticulously explains the biochemical transformation of AKG into glutamate and reviews strategies to counteract these negative impacts, including the use of supplements like B6 and Niacin.
He concludes by weighing the pros and cons of AKG.
Tune in to learn more about AKG supplementation, its potential benefits, and how to safely navigate its use for optimal health outcomes
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In this episode, we delve into the pivotal role of the BHMT gene within the body's methylation process.
We discuss how the BHMT enzyme is essential for catalyzing a vital reaction that transforms homocysteine into methionine.
Additionally, we cover the importance of betaine in enhancing the methylation cycle. Betaine acts as a methyl donor, particularly in the reaction facilitated by the BHMT enzyme, making it crucial for reducing homocysteine levels and supporting cardiovascular and neurological health.
We also explore the complexity of methylation pathways and emphasize the need for a comprehensive evaluation of multiple genes to truly understand and optimize methylation.
Be sure to follow our podcast for more expert insights into how betaine, methylation, and genetics can be leveraged to optimize both body and brain health.
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In this episode, Joe tackles a controversial new study that suggests even 25 milligrams of niacin could potentially increase the risk of heart disease.
Delving deep into the world of niacin supplementation, Joe discusses how, despite these concerns, niacin offers numerous health benefits, including enhanced cognitive function, better mood, and increased energy levels.
Joe draws on personal experiences to compare the negatives against the significant positives of niacin, as he explores niacin's biochemical effects, particularly its interaction with proteins such as 2PY, 4PY, and VCAM1, all linked to cardiovascular health.
Throughout the episode, Joe examines the importance of dosage, sharing insights into the varying effects of low versus high doses of niacin.
Join Joe as he navigates the complexities of niacin use, advocating for a well-informed, nuanced approach to its benefits and risks.
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In this episode, we explore the complex interplay between the CNR1 gene, cannabinoid receptors, and cannabis.
Discover the role of the endocannabinoid system in maintaining bodily balance, particularly in brain function, mood regulation, and inflammation response.
We delve deep into how genetic variations in the CNR1 gene can influence the CB1 receptors, and the implications of CB1 receptor function in managing stress, anxiety, and cognitive processes such as memory and decision-making.
Whether you're curious about the science behind getting high or looking for ways to optimize your cannabinoid system through diet and supplements like CBD oil, this episode has something for everyone.
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In this episode, we explore the crucial role of serotonin in managing anxiety and enhancing mental wellbeing.
Discover how serotonin not only influences mood but also plays a pivotal role in anxiety regulation and mental health.
Learn about the HTR1A and HTR2A genes, which act like switches, controlling the serotonin levels in the brain.
Understanding the SNPs in these genes can provide personal insights into your serotonin activity, offering potential strategies to alleviate anxiety, depression, and other mental health disorders.
The episode further discusses how various serotonin receptors, affected by genetic differences, impact numerous physiological and psychological functions.
Gain practical advice on how to balance your serotonin levels through diet, lifestyle choices, and supplements tailored to your genetic makeup, and see how this can significantly improve your mood and reduce anxiety.
If you're interested in learning more about how your DNA and genetics affect your health:
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In this episode, Joe takes questions from SelfDecode members, answering questions like:
- What makes SelfDecode different from other DNA companies?
- How does the recommendations engine work?
- Can you find out if a certain supplement is right for you?
Plus, he shares some of his genetic predispositions and how they correlate with his lab levels!
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In this episode, we delve into the critical process of methylation, highlighting its significant impact on health issues ranging from heart disease to mental health and focusing on a lesser known methylation gene - MTHFD1.
We focus on the MTHFD1 gene and choline's significance beyond methylfolate and Vitamin B12 for undermethylators.
Discover how MTHFD1 impacts methylation by metabolizing tetrahydrofolate and how choline is important in supplying methyl groups.
We highlight the impact of a negative MTHFD1 variant on choline usage and the potential consequences of choline deficiency, while also stressing the importance of considering other genes involved in methylation, not just MTHFR and MTHFD1.
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This episode was originally published on April 12, 2015.
Dr. Jack Kruse and Joe explore unconventional approaches to health through the lens of physics and biochemistry.
They cover topics like the critical roles of mitochondrial function, environmental factors such as EMFs, blue light, and dietary choices on our well-being, and challenge common health paradigms, emphasizing the importance of circadian biology, the effects of cold exposure, water quality, and the necessity of questioning mainstream nutritional advice.
Next, they focus on aligning with nature's design through sunlight exposure, understanding electron flow, optimizing DHA intake, and reducing exposure to non-native EMFs.
These conversations aim to encourage curiosity over conforming, urging listeners to consider the interconnectedness of their biology with their environment in the pursuit of optimal health.
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In this episode, we delve into the science behind the MAOB gene and monoamine neurotransmitters.
Join us as we explore the crucial role of dopamine, serotonin, and norepinephrine in regulating mood and cognition.
We dissect the function of the MAOB gene in metabolizing neurotransmitters and discuss the implications of genetic variations on mental health.
From increased breakdown linked to mood disorders to decreased activity associated with elevated neurotransmitter levels, we unravel the complex interplay between genes and mental well-being.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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In this episode, Joe dives into the world of personalized wellness with Lauren Sambataro and Renee Belz, known as The Biohacker Babes.
With roots in wellness and holistic dentistry, The Biohacker Babes bring their wealth of expertise as health entrepreneurs, nutritional consultants, and holistic lifestyle coaches to the table.
In this enlightening conversation, we explore the pivotal role of lab testing in crafting personalized health regimens, emphasizing essential tests such as CBC, CMP, and functional lab tests.
The Biohacker Babes also dive into the complexities of hormone regulation, genetic predispositions, and the profound impact of stress, diet, and environment on overall health, as well as discuss advanced testing methodologies including organic acids tests, the GI MAP test, and the Dutch test, designed to fine-tune health interventions for maximum effectiveness.
Join us as we navigate the landscape of personalized wellness with the Biohacker Babes, unlocking the secrets to a vibrant, thriving life.
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Visit https://thebiohackerbabes.com/
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Timestamps:
(0:00) - Intro
(1:10) - Important lab tests for Biohacker Babes
(5:45) - Digestion
(10:30) - Amino acids
(15:09) - Analyzing Joes biochemistry
(22:47) - Heavy metals testing
(29:52) - CGM & HRV
(41:57) - Epigenetic aging tests
(44:42) - Continuing with digestion
(51:55) - Food sensitivities
(55:01) - GI Mapping
In this episode of The Joe Cohen Show, we dive deep into the world of dopamine.
We'll be focusing on the role of genetics, specifically the DRD2 gene, in regulating dopamine levels and how it affects your brain's reward system, motivation, and susceptibility to addiction.
Here's what you can expect to learn:
- How the DRD2 gene influences dopamine D2 receptors and their impact on pleasure-seeking behaviors.
- Understanding the variants of the DRD2 gene and its link to dopamine receptor.
- How genetics can affect motivation, reward processing, and potentially lead to a dopamine imbalance.
- The importance of maintaining balanced dopamine levels for optimal cognitive function.
Join us as we explore the fascinating world of dopamine and genetics!
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Join us for an enlightening roundtable discussion featuring health experts Joe Cohen, Kris Gethin, Tim Gray, and Siim Land as they dive deep into the world of health optimization.
In this episode, our expert panel explores a wide range of health tests and biomarkers, from basic to advanced, and what they mean for your health, including VO2 max assessments, heart rate variability, full-body MRI scans, gut microbiome analysis, and food sensitivity testing.
We also discuss topics like EMF and heavy metal sensitivity, shedding light on how these factors can impact overall health.
Get exclusive insights into the advanced wellness center AIWO and its groundbreaking solutions, and discover how AIWO's cutting-edge approach is revolutionizing health and wellness.
But it's not just about theory—our panelists also share their personal experiences and tips gained throughout their own health journeys. From overcoming obstacles to achieving peak performance, they provide actionable advice to help you optimize your health and live your best life.
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Timestamps:
(0:00) Introduction
(00:21) The AIWO Experience
(47:31) Heart Rate Variability
(53:11) VO2 max
(56:22) Joe's Favorite Supplement for Recovery
(58:39) Sound changes here
(01:05:33) EMF & Heavy Metal Sensitivity
(01:13:29) Digestive Enzymes
(01:20:22) Kris' Top Health Hack
Love is in the air as we dive into the science behind relationships.
In this episode, we explore the fascinating world of oxytocin, affectionately known as the "love hormone," and its connection to the OXTR gene.
Responsible for encoding the oxytocin receptor, this gene plays a crucial role in shaping our social bonds, empathy levels, and even cognitive abilities. We discuss groundbreaking research, including the 'happy marriage study,' which unveils intriguing insights into how our genetic variations may influence our relationship dynamics.
We uncover how oxytocin, influenced by the OXTR gene, extends beyond social bonding, playing a pivotal role in enhancing cognitive functions. Could our brain development be intricately tied to our social interactions?
Join us on this journey through the science of love and genetics.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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In this episode, Joe discusses skin health, anti-aging strategies, and the science behind skincare with biohacker and beauty industry leader Amitay Eshel, CEO of Young Goose.
Amitay shares his expertise on improving skin health through a combination of internal health, high-quality skincare products, and biohacking techniques.
The conversation covers topics such as the efficacy of various skincare ingredients, the impact of sun exposure, and innovative approaches to anti-aging.
Amitay also delves into the science of skin renewal, the role of vitamins and metabolites in skin health, and offers practical advice on creating an effective skincare regimen tailored to individual needs and skin types.
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Use code “SELFDECODE” for 10% off younggoose.com
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In this episode, we uncover the significance of the CLOCK and PER2 genes, pivotal players in regulating your body's circadian rhythm. Learn how these genes influence your sleep patterns, alertness levels, and even your predisposition to certain health conditions.
Discover how variants in the CLOCK gene can impact your circadian rhythm, sleep duration, and daily activity patterns.
Explore the associations between genetic variations in the PER2 gene and your tendency to be an early riser or a night owl, as well as its influence on sleep disorders and mood.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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In this episode, Joe brings on Dr. Ben Lynch - renowned geneticist and author of Dirty Genes - to unreavel the science of methylation, MTHFR, folates, and homocysteine.
Dr. Lynch intricately unpacks the complexities of methylation pathways, shedding light on how genetic variations can impact these crucial processes.
Joe and Ben then delve into the specifics of homocysteine metabolism and the role of B vitamins in maintaining optimal levels.
They provide invaluable insights into personalized supplements tailored to address individual genetic predispositions and health needs.
Explore the latest advancements in methylation and homocysteine management, and discover actionable strategies for promoting longevity and optimal well being.
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Visit @drbenlynch on Instagram
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Use code "SelfDecode10" to get 10% off seekinghealth.com
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Timestamps:
(0:00) - Intro
(1:09) - State of the genetics industry
(20:07) - MTHFR and methylation
(1:04:59) - Is overmethylating real?
(1:12:06) - Riboflavin and other B vitamins
(1:18:06) - How many supplements does Ben take a day?
(1:31:54) - Epigenetics and other alternative tests
In this episode of SNPit, we delve into the fascinating world of the FOXO3 gene, a genetic guardian that holds the key to a longer life.
But here's the twist: did you know that certain variants of this gene could impact your lifespan more than smoking a pack of cigarettes every day for 25 years?
We uncover the research behind this startling revelation and discuss the implications for our health and well-being.
Plus, we reveal actionable steps you can take to optimize your FOXO3 gene for better longevity.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Joe delves deep into the world of biohacking alongside esteemed naturopath Michael Smith.
Drawing on two decades of expertise, Michael shares invaluable insights into optimizing health, particularly focusing on gut health and the microbiome.
From his personal journey to professional practice, Michael discusses the latest advancements in gut health research, tackling issues such as fatigue, autoimmune conditions, and more.
Michael shares some practical strategies for enhancing gut health and addressing chronic conditions.
Join Joe and Michael as they explore the pivotal role of lifestyle changes, targeted supplements, and personalized DNA data in achieving optimal well-being.
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Learn more about Michael’s practice at https://www.planetnaturopath.com/
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Check out SelfDecode: https://selfdecode.com/
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Timestamps:
(0:00) - Michael Smith
(01:51) - Michael's process with patients
(10:34) - Important health data points
(19:21) - Looking at gut health
(27:35) - Food sensitivities and gut health
(32:56) - Other alternative markers and tests
(38:44) - Going through test results
Today, we're excited to bring you the cream of the crop – the top 6 health advice of Season 5 - that have not only resonated most with our listeners but have the power to transform your approach to health and wellness.
These highlights encapsulate the essence of what it means to live well in today's world. Each clip has been handpicked for its impact, insight, and potential to inspire positive change in your life. Whether you're a long-time listener or just joining us, this episode is your gateway to the best health advice we've uncovered in Season 5.
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Timestamps:
(0:00) - Intro
(0:16) - Oz Garcia
(8:31) - Methylation
(17:44) - Michael Lustgarten
(24:26) - Optimal Lab Levels
(29:37) - Matt Kaeberlein
(46:34) - Immune System
Get an in-depth overview of the components of the immune system, learn how to identify when they're compromised, and get insights on how to support them to prepare your body for illness.
Joe discusses the importance of focusing on immune support before illness occurs, diving deep into the roles of mitochondria, extracellular matrix, and inflammation, and how their strengths affects the immune system - sharing key supplements that help optimize each component!
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In this episode, we focus on the FTO gene's pivotal role in fat metabolism, appetite, and weight management.
Get an in-depth analysis of how the FTO gene not only influences body weight and obesity risk but also regulates appetite and fat metabolism, alongside managing emotional eating and hunger levels.
We discuss the gene's connection to weight-related challenges, including its effects on insulin resistance, blood sugar levels, and energy expenditure.
By understanding one’s genetic predispositions, individuals can adopt personalized approaches to diet, lifestyle, and supplementation, turning genetic insights into actionable plans for improving fat metabolism and achieving weight management goals.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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In this episode, Dr. Matt Kaeberlein, CEO of OptiSpan and co-director of the Dog Aging Project, and Joe explore the fascinating realm of rapamycin and its implications for longevity and healthspan.
Dr. Kaeberlein delves into the biological mechanisms underlying rapamycin's effects, the best way to take it, and its impact on immune system processes.
Gain insights from Dr. Kaeberlein's research on the mTor mechanism and rapamycin, uncovering their promising potential in extending healthspan and enhancing lifespan.
Finally, Matt and Joe discuss aging clocks, biomarkers, and microbiome tests, evaluating their significance in the context of aging research and longevity enhancement.
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Visit https://www.optispan.life/
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Timestamps:
(0:00) - Intro
(02:24) - Rapamycin overview
(22:04) - How Matt uses Rapamycin
(33:24) - Biomarkers affected by rapamycin
(37:33) - Microbiome and aging clocks
(01:04:07) - How much can you maximize life span
Dive into the world of lab testing and unlock the secrets to optimal health.
In this episode, Joe sheds light on the crucial role lab tests play in understanding our health, cautioning against the limitations of standard tests often offered by conventional medicine.
Delve deep into the realm of comprehensive testing as Joe shares his insights on a variety of essential lab markers, including Complete Metabolic Panel, Complete Blood Count, Thyroid Panel, and Amino Acid Panel, among others.
Learn why these tests are vital for gaining a holistic view of your well-being.
Discover common misconceptions surrounding lab tests and explore the benefits of leveraging advanced tools like SelfDecode for managing and analyzing your lab results effectively.
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Timestamps:
(0:00) - Intro
(0:40) - Mistakes people make when taking lab tests
(5:06) - Important lab tests
(11:34) - My journey with labs
(14:55) - The lab tests I take every quarter
We unravel the intricate relationship between sunlight, Vitamin D, and your genetic makeup, as we explore the pivotal role of Vitamin D in optimizing health and well-being.
At the heart of this discussion lies the VDR gene, a genetic blueprint responsible for producing the Vitamin D receptor, as we uncover it’s role alongside Vitamin D in the body.
We delve into the fascinating journey of Vitamin D synthesis, from sun-kissed skin to the activation of calcitriol, the biologically active form of Vitamin D.
Understanding your unique genetic profile empowers you to make informed decisions about your health, from tailored dietary adjustments to personalized supplement strategies. So, join us on this genetic exploration and unlock the secrets of optimal health.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Join Joe in a conversation with successful biohacker and CEO of Neurohacker Collective, James Schmachtenberger.
James shares his two-decade-long journey with biohacking, focusing on improved energy, cognitive function and how NAD changed his life.
Learn about utilizing research, software solutions like genetics and lab tests, lifestyle changes, and supplementation for optimizing your health.
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Use code “SELFDECODE” to get 15% OFF any product at neurohacker.com
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Timestamps:
(0:00) - Intro
(1:28) - Jame’s first supplements and approach
(8:24) - Energy and mental clarity
(13:11) - Putting health into your own hands
(19:55) - Studies on Lyme Disease
(22:47) - Trusting your intuition vs a data driven approach
(30:17) - Exercise
(37:22) - Taking too many supplements
(45:29) - The one lab marker always affected by infection
(52:48) - Collagen and joint
(59:02) - NAD
(1:09:30) - Different Qualia Products
(1:11:25) - Unique biohacks
Ever wondered why some people seem to avoid sickness effortlessly, while others catch every bug in the vicinity? It turns out, luck and genetics may both play a role.
In this episode, we uncover the secrets of the IL6 gene, responsible for coding interleukin 6 (IL-6), a crucial immune messenger.
Discover how certain variants of the IL6 gene, such as rs1800795, are linked to higher or lower IL-6 levels, affecting immunity and susceptibility to infections.
But the story doesn't end there – we explore other variants like rs1800796, connecting genetic makeup to conditions like acne, longevity, muscle recovery, and inflammatory diseases.
Is your IL6 gene making you ill, or is it your genetic strength?
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Unlock the secrets to longevity with our deep dive into biohacking, lab tests, and supplements! In this episode, we explore the crucial role of lab markers in longevity, optimal lab test ranges, and associations that impact aging. Dive into the world of supplements, addressing concerns about tolerance and when is the right time to supplement for lifespan. Joe and Michael discuss the Dunedin Pace Test and its significance in aging, while shedding light on the impact of lifestyle changes and immune system health. Going deeper into the science, Michael and Joe analyze mortality risk, liver damage, protein intake, urea lives, fiber intake, calorie restriction and so much more on biological aging.Join us on this journey of discovery, as we discuss data points, close with valuable insights, and chart our future plans for further exploration into the fascinating world of longevity.
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
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Visit Conquer Aging or Die Trying!
Timestamps:
(0:00) - Introduction
(2:54) - How many supplements does Michael take?
(11:44) - Red blood cells
(14:47) - Can you increase longevity with no supplements?
(29:36) - Dunedin Pace
(37:28) - Longevity based lab markers
(40:06) - The immune system
(42:36) - Labs affected by too much supplementing
(57:00) - Testosterone and LDL
(1:01:39) - New study on aging
(1:08:09) - Protein and amino acids
(1:13:30) - Urea and protein
(1:18:30) - Body fat and BMI
(1:23:57) - Supplementing vs training
(1:30:23) - Michael’s current diet
(1:33:34) - Michael’s current work
(1:47:17) - Urea and Uric Acid
(1:53:31) - Caloric restriction and longevity
This episode explores the transformative potential of the UGT1A1 gene in your body’s ability to detox toxins.
Uncover the role of this gene in Glucuronidation, a crucial chemical reaction that enhances the body's ability to detoxify.
Learn about the impact of genetic variations which can reduce the activity of the UGT enzyme, hindering the body's detox capabilities. Discover practical solutions to counteract toxic buildup and support the body's natural detoxification processes.
This episode unveils the science behind genetic detoxification, providing valuable insights into personalized approaches for optimal health.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
In this episode, Joe discusses the fascinating topic of methylation and its importance for overall health.
From explaining the tests that can determine if you're an over or under methylator, to providing recommendations on how to support your methylation process, Joe covers everything you need to know.
Discover how genetic variations, such as MTHFR and MTRR, can impact your need for nutrients like folate and B12.
Get insights into specific lab markers and supplements that can help optimize your methylation levels.
Find out how sleep, exercise, stress management, and detoxification play a crucial role in methylation.
Join Joe as he shares his expert knowledge on methylation and provides practical strategies to improve your wellbeing.
If you're interested in learning about how your DNA and genetics affect your health, you can:
-
Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Join us on an exhilarating journey into the intricate world of choline and the PEMT gene.
Delve into the significance of choline and how it impacts cellular health, brain function, and beyond, and how PEMT plays a role in choline production.
Discover the intricate genetic variants within PEMT, unravelling how certain alleles influence susceptibility to choline deficiency and associated risks.
Plus, learn how estrogen stimulation plays a crucial role, posing unique challenges for different demographics.
Tune in to 'SNPits' on The Joe Cohen Show to grasp the genetic intricacies impacting our health and explore how personalized nutrition can be your shield against genetic vulnerabilities.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
In this episode, we delve deep into the importance of the immune system and how you can optimize it for peak performance.
Immunity isn't just about avoiding the common cold; it can impact all areas of health, from physical wellness to mental clarity.
Joe, a seasoned biohacker, shares his personal experiences and strategies for ramping up immunity, shedding light on how a data-driven approach can yield significant benefits.
We also explore a comprehensive protocol for when you do get sick, outlining a series of steps incorporating diet changes, specific supplements, and unique lifestyle adjustments.
From baths to peptides, discover an array of techniques to fortify your body's defenses and recover faster from illness.
Join us for this enlightening conversation that will leave you better prepared to face health challenges head-on.
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Timestamps:
(0:00) - Intro
(1:02) - What Oz Tests For
(5:08) - Pros and cons of testing
(11:15) - Muscle & Tendon Recovery
(22:13) - How to decrease homocysteine
(29:57) - Immunity
In this episode, Joe dives deep into the fascinating world of MTHFR and what you can do if you carry the negative variants!
Join us as we unravel the mysteries surrounding these important topic and explore everything you need to know about genetic variations, folate metabolism, and the crucial role of methylation in our bodies.
Joe breaks down the science behind MTHFR, explains how to interpret your genetic results, and shares valuable insights on optimizing your folate levels.
Discover the benefits of methylfolate, explore the connection between homocysteine and methylation, and learn practical tips for supporting your overall health.
If you're curious about the inner workings of the MTHFR gene and how it influences your well-being, this episode is for you!
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
You’ve probably heard of the hype around MTHFR and how it affects methylation, but what about other genes implicated in the methylation process?
In this SNPit the spotlight shifts to MTR and MTRR, and how they can affect levels of homocysteine in the body. Learn all about why homocysteine is important, how genetic variants can affect your levels, and other factors that affect methylation.
… Because MTHFR doesn’t tell the whole story.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
In this episode of the Joe Cohen Show, we welcome Dr. Darshan Shah, a renowned health specialist, surgeon, author, and founder of Next Health. We dive deep into the cutting-edge health optimization methods used at his clinic to extend lifespan and health span. Dr. Shah shares intriguing insights on the role of biohacking, the importance of managing metabolic disease, micronutrient testing, and the function of certain nutrients in our bodies. Throughout the discussion, Joe demonstrates how he uses SelfDecode to analyze his personal health data, illuminating the power of personalized health management.
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Follow @darshanshahmd on Instagram
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Visit Next Health: https://www.next-health.com/
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Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Timestamps:
(0:00) - Introduction
(01:16) - The journey of extending lifespan with Dr. Shah
(04:15) - Most common lab markers that are high
(07:19) - Optimizing for insulin and cardiovascular health
(20:59) - Tests for cancer
(22:26) - Becoming the CEO of your health
(28:07) - Micronutrient testing
(33:43) - Amino acid tests
Dive deep into the fascinating world of brain health, brain mapping, and the game-changing impact of neurofeedback on anxiety, sleep, executive function, and so much more.
In this episode, Dr. Andrew Hill - a neuroscientist with a Ph.D. in Cognitive Neuroscience from UCLA and is best known as an expert neurofeedback practitioner and brain fitness coach - shares his decades of knowledge to help us understand the power of neurofeedback.
Discover the pivotal role of brain mapping in tailoring personalized neurofeedback treatments, how certain brainwaves in different areas of the brain affect your cognition, and what you can do to optimize sleeping patterns, reduce anxiety, and even IMPROVE your social skills!
Discover the nuanced impact of brainwaves like theta and beta waves on cognition. Explore how focusing on these waves can optimize specific areas of your health, from enhancing executive function to reducing anxiety and improving sleep patterns.
Join us for an eye-opening journey into brain health and neurofeedback.
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Use code “SELFDECODE” to get 50% off unlimited brain mapping at https://peakbraininstitute.com/
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Dive into the world of immunity optimization with Joe and Siim Land - all the way from India!
From supplement stacks to proactive measures for bolstering the immune system, Siim and Joe dissect their distinct immune-boosting protocols aimed at fortifying immunity and enhancing the body's defense mechanisms.
Joe and Siim share their tailored approaches to prevent illness and expedite recovery when under the weather.
Gain exclusive insights into their supplement regimens, tailored to optimize immune response and foster resilience against sickness.
Highlighting key lab markers crucial for optimizing health, Joe and Siim also shed light on the pivotal metrics they prioritize, uncovering the essential lab markers important for monitoring and fine-tuning immune function.
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Check out SelfDecode
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Join Joe’s online community
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Follow Siim Land on Instagram
Unlock the mysteries behind methylation, MTHFR, and homocysteine! Join us as we dive into these widely recognized yet often misunderstood terms that impact heart health, mental well-being, fertility, and more.
The surge in popularity around methylation, MTHFR, and homocysteine has led to a barrage of misinformation.
In this enlightening episode, we've invited Dr. Denise Furness, a distinguished molecular geneticist boasting over two decades of expertise in folate nutrigenomics, methylation, and DNA damage.
Join us for a wealth of game-changing insights as Denise delves deep into:
- Understanding methylation's pivotal role in your health
- Unraveling the impact of the MTHFR gene on methylation levels
- Optimal homocysteine levels and their significance
- Essential lab markers for optimizing your health
- Debunking concerns about over-methylation
If you're interested in learning more about how your DNA and genetics affect your health, you can:
-
Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
I’m thrilled to be back with a brand-new season of The Joe Cohen Show!
We’re kicking off the season with truly life-changing knowledge with a popular returning guest, Dr. Oz Garcia!
In this episode, Dr. Oz Garcia and I explore the keys to happiness, the transformative power of meditation, and the world of biohacking for pain reduction and sleep optimization!
We dive into the intricacies of mood, discussing all the different pathways that affect your overall mood and the different approaches to consider depending on your unique biology.
Are you dependent on serotonin for improved mood? Is your GABA pathway the culprit for your bad days? What about the vagus nerve? Dr. Oz highlights how treatments are completely different based on your body's needs!
As the conversation unfolds, you'll find yourself immersed in discussions about mood and pain, as Dr. Oz shares some of his secret supplements and lifestyle hacks that reduce his pain and allow him to continue doing all the physical activities that he loves.
In this special episode, we've curated the most influential moments and expert insights from some of our remarkable guests of Season 4.
Get ready to uncover a treasure trove of tips and tricks to supercharge your health and well-being. From optimizing gut health to longevity secrets, this episode is your ultimate guide to living your best, healthiest life. Tune in now for a power-packed journey into the world of wellness and discovery. Don't miss out on this collection of wisdom from the best in the field!
Have you ever wondered if a single gene could hold the key to unlocking your cognitive potential, or perhaps, be the culprit behind those moments of brain fog?
Discover the fascinating world of the BDNF gene in this episode of SNPits.
Explore how your genetic makeup can impact your cognitive function and memory and uncover the association between BDNF variants and brain health.
Plus, learn how to naturally boost your BDNF levels for improved learning and mental performance.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
-
Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Do you find it hard to drift off to sleep at night? Wondering why some nights are filled with vivid dreams while others leave you feeling like you've barely closed your eyes? What's the true impact of those late-night screens and the foods we consume on our sleep cycle?
In this episode, Joe and Dr. Greg answers questions unraveling the mysteries of sleep and revealing the intricacies of our body's internal clock.
Together, they explore the pivotal role of sleep in our overall health, spotlighting specific genes that might influence your sleep patterns and how you can modify your habits for a restful night.
Shifting their attention to nutrients and dietary habits, they identify certain foods and minerals that promote sleep, like tryptophan and melatonin.
From understanding genes like PER and CLOCK that regulate our circadian rhythms, to the essential role of diet, this episode is a comprehensive exploration of the science behind sleep!
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Check out SelfDecode
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Join Joe’s online community
Timestamps:
(0:00) - Intro
(7:10) - Why do sleep disorders increase with age?
(7:45) - How can I easily fall asleep?
(14:56) - sleeping a lot but still tired
(18:09) - Waking up in the middle of the night
(26:54) - Waking up panicked
(30:32) - Is there a way to increase slow wave sleep?
(33:21) - Can SAD bring on insomnia?
(34:43) - melatonin genes and sleep
(36:28) - inconsistencies in sleep?
(37:17) - how do I make sleep more restorative
(38:35) - Is napping okay?
(40:32) - How to increase REM sleep time?
In this episode of the Joe Cohen Show, we dive deep with renowned nutritionist Dr. Oz Garcia.
With a lifetime of experience in the realm of nutrition, Oz shares his transformational journey from being a "rockstar nutritionist" to confronting the challenges of his own health issues.
We explore the importance of not just focusing on what we eat, but also delving into data-driven wellness practices that can pave the path to optimal health.
Learn about the markers and biomarkers that matter, how to achieve resilience in the face of illness, and why a data-driven approach is the key to unlocking true health.
Whether you're a health enthusiast or a professional in the field, this conversation with Oz Garcia is an essential guide to elevating your nutrition strategy and achieving optimal health.
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visit ozgarcia.com
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Follow Oz @ozwellness
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Check out SelfDecode
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Join Joe’s online community
Timestamps:
(0:00) - Intro
(1:52) - Oz's process in helping a client get healthy
(18:56) - Changing the way we look at health
(34:59) - Supplements and reading lab levels
(53:27) - Meditation and spiritual practices
The pursuit of optimal health is a lifelong journey, so finding the motivation to continue to make the right decisions can sometimes be difficult.
If you’re not working on a tangible goal - like running a marathon or reaching a PR in squats - then how can you keep yourself from falling into unhealthy habits?
In this episode, Andrew Steele - former Olympian and co-founder of DNAfit and Aila - and Joe share tips on how to set realistic goals that keep you striving for optimal health and performance.
Andrew discusses the importance of health trackers in understanding your next steps, and shares how you can start becoming more aware of your diet and supplement changes to fuel you on your road to optimal health.
Both Joe and Andrew share their lifechanging journey with genetics, and how they’re now incorporating labs to get a holistic picture of their health.
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Visit https://meetaila.com/
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Chronologically, you get 1 year older every year. But how old are you getting biologically?
In order to optimize longevity, you need to understand biological aging.
With all the different longevity and biological aging tests, it can be difficult to understand where to start.
Fortunately, we got Ryan Smith from Tru Diagnostic on todays episode to guide you on all things longevity and biological aging.
In this episode, Ryan highlights the different biological aging tests and which one is the most accurate.
He also gives helpful tips on how to reduce your pace of aging, and how that’s important for your overall lifespan.
Ryan Smith is founder of TruDiagnostic, which has created the largest private epigenetic database in the world with over 25,000 patients tested. From this dataset, they have created many new algorithms to interpret methylation data including algorithms to predict inflammatory markers, disease diagnosis, telomere length, aging pace, immune cell subsets, cellular replication, and more.
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Visit trudiagnostic.com
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Check out SelfDecode
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Join Joe’s online community
Timestamps:
(0:00) - Intro
(1:48) - Where does epigenetics fall into aging biomarkers?
(21:52) - Different responses in anti-aging protocols
(39:44) - epigenetic test vs lab tests
(48:42) - How to use biological age tests to improve health
(55:09) - pace of aging
(1:05:15) - Immune system age
(1:09:11) - How to reduce the pace of aging
(1:26:39) - How many supplements does Ryan take per day?
(1:35:42) - Metformin and rapamycin on aging
Is the ApoE gene solely a predictor of cognitive decline, or is it just one piece of a larger, more intricate puzzle?
In today's episode, we focus on the ApoE gene, a genetic player that’s most notoriously linked to Alzheimer's Disease.
Julia dives deep into the three major variants called E2, E3, and E4, discussing how they change the shape of the ApoE protein and impact how well it functions.
she also opens up the curtain on other health issues that can be caused by the ApoE gene —impacting your cardiovascular health, your body's inflammatory responses, and even your longevity.
Join us as we explore the layers of ApoE, debunk misconceptions, and discuss how understanding this gene could be a key step in taking control of your cognitive and overall health. Whether you're a genetic novice or a seasoned veteran in the world of SNPs, this episode will provide a comprehensive, yet easy-to-understand look into the multi-faceted role of the ApoE gene.
If you're interested in learning more about how your DNA and genetics affect your health, you can:
-
Check out SelfDecode: https://selfdecode.com/
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Join Joe’s online community: https://thejoecohenshow.com/
Why are there so many different versions of the same supplement? Is it all just a marketing ploy, or do they all have different effects on your health?
In this episode, Emiel Bakker from Nootropics Depot comes on to dive into the complex world of dietary supplements, where not all products are created equal.
He gives us an inside look at the science behind developing a supplement, from deciding on an extraction method to choosing between a fruiting body vs. mycelium.
We uncover the nuanced factors that influence the efficacy and effects of some popular supplements, including:
- Lions Mane: How can different extraction methods affect its cognitive benefits?
- Bacopa: How to navigate its varieties for optimal memory enhancement.
- Saffron: Its antidepressant effects and the factors that contribute to its potency.
- Ubiquinol vs CoQ10: The dynamic duo of cellular energy—what's the difference and why does it matter?
And more!
Emiel Bakker is the product specialist at Nootropics Depot and Natrium Health, a company specializing in creating the best nootropic powders and capsules online. They offer pure nootropics and dietary supplements at the best prices.
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Visit Nootropics Depot website
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Find Emiel @prettychill_nd
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Check out SelfDecode
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Join Joe’s online community
Timestamps:
(0:00) - Intro
(2:07) - Different variations of the same supplement
(17:21) - Erinacine A and Lion’s Mane
(19:57) - Pregnenalone
(26:51) - Tetrahydromagnolol and Magnolia Bark
(40:36) - How SelfDecode helps you understand supplements
(42:29) - Bacopa for Serotonin
(57:58) - Different effects of Maca
(1:09:28) - Oroxylin A and effects on cognition
(1:13:53) - Effects of Saffron
(1:20:28) - How many supplements do you take a day?
(1:22:33) - Ubiquinol vs CoQ10
(1:24:29) - Licorice Extract
How can you measure autophagy for certain? And what are the key stages to an effective fasting regimen?
Returning guest, Dr. Joseph Antoun from L-Nutra, the visionary company spearheading the fast-mimicking diet revolution, is here to answer these questions.
In this enlightening conversation, we delve into:
- New clinical trials that prove the fast-mimicking diet not only mimics fasting but enhances the benefits.
- The science of autophagy: What it is, its tremendous health benefits, and groundbreaking methods for measuring it—no more guesswork!
- The three stages of fasting, and how you can reach each one for optimal health benefits
- Dr. Antoun's recommended frequency for a 5-day fasting regime per year—because timing is everything.
- How to nail intermittent fasting and incorporate it seamlessly into your life.
- A deep dive into clinical trials that show the fasting mimicking diet can actually reverse diabetes.
And so much more!
Dr. Joseph Antoun is the CEO & Chairman of the Board of L-Nutra and a Member of the Forbes Business Development Council. He is also the former CEO of Health Systems Reform, an organization committed to optimizing public health.
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Get 20% OFF All Products at https://l-nutra.com/ by using Code “JOE20”
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-
Join Joe’s online community
Timestamps:
(0:00) - Intro
(2:58) - Fasting mimicking diet best benefits
(5:12) - Discussing autophagy
(23:58) - Recommended number of times to fast
(26:10) - Fasting for diabetes
(28:27) - How to properly do intermittent fasting
(42:00) - Nutrient sensing
(47:43) - Theories on stem cells
(50:02) - Clinical trials supporting fasting mimicking
(54:57) - Biological aging tests
(1:07:56) - Does Joseph take supplements?
Welcome back to SNPits, a short form series helping you decode your DNA, one gene at a time.
In this episode, we delve into the fascinating world of the COMT gene, commonly dubbed the "Warrior/Worrier" gene.
We unpack the science behind this gene's influence on stress regulation, emotional resilience, and even cognitive function.
Is the "Warrior/Worrier" label an oversimplification, or does it offer a genuine glimpse into our genetic predisposition?
Whether you're well-versed in genetics or just taking your first steps into this fascinating realm, today's episode promises to be an intriguing exploration of the role genes play in shaping our reactions to life's challenges.
Links:
The warrior variant and its effects on stress and working memory [R, R, R, R]
The worrier variant and its effects on stress and emotional resilience [R, R, R, R, R].
Join us as we dive deep into the world of genomics, nutrition, and precision health with Dr. Greg Nacarelli, a leading expert in naturopathic medicine and genetics.
Dr. Nacarelli delves into the intricate interplay of genetics, environment, and lifestyle on our health, explaining why personalizing health care is the future.
Greg touches on the value of understanding individual genetic profiles and how this can be utilized for personalized nutrition and health coaching.
With extensive academic qualifications and years of experience working with SelfDecode, Greg brings a unique blend of expertise to the table.
Whether you're a health professional or just a health enthusiast, this episode offers invaluable insights into the cutting-edge world of genomics and how it's shaping the future of personalized medicine.
Timestamps:
(0:00) - Intro
(2:53) - Practitioners Course
(8:09) - How A Health Practitioner Uses SelfDecode
(16:55) - Using the recommendations feature
(25:44) - Continuing the health practitioners use of SelfDecode
Dive deep into the intricate world of gut health with the pioneer himself, Dr. Steven Gundry.
Once dismissed as pseudoscience, the concept of 'leaky gut' has become a cornerstone of modern health understanding, and no one knows this better than Dr. Gundry.
In this enlightening episode, we unravel the real science behind leaky gut, the dangers of food sensitivities, and the profound effects of glyphosate on our system.
Beyond just understanding, Dr. Gundry shares actionable insights on optimizing your gut health to transform your overall well-being.
Whether you're a long-time health enthusiast or just beginning your journey, this episode offers a treasure trove of knowledge.
Timestamps:
(0:00) - Introduction
(3:30) - Dr. Gundry's current ideal diet
(9:12) - Autoimmune Disease Reversal & Leaky Gut
(17:08) - IgG Antibodies
(27:29) - Other markers attributed to leaky gut
(34:14) - Glyphosate and linoleic acid
(48:20) - Top things to counteract food sensitivities
(54:23) - LPa, ApoB and LDL Cholesterol
(1:02:09) - Thoughts on diet studies with beans and whole grains
(1:05:44) - Protein Restriction & Intermittent Fasting
(1:11:08) - Fibers and gas
Welcome to SNPits, a new, short-form podcast series that takes you on a deep dive into specific genes, unraveling the science behind them and their impact on health.
In this episode, we tackle the MTHFR gene and its rise to fame.
We explore how 'typos' in our genes, known as SNPs, influence our health, and dive into the debate surrounding one of the most studied genes in the world.
Is the MTHFR gene truly a culprit in conditions like heart disease and chronic fatigue, or is it a scapegoat?
Join us as we decode the science, bust some myths, and take a closer look at how our genes really affect our health. Whether you're a genetics guru or new to the subject, this episode offers an insightful and entertaining look at the complexity of our genetic code.
Links:
Some studies found a 35-70% reduction in enzyme activity [R], and links between MTHFR variants, higher homocysteine, and:
- Heart disease and stroke [R, R]
- Fertility and pregnancy issues [R, R, R, R, R, R]
- Mental health issues [R]
- Migraines with aura [R, R]
Some studies found no evidence for these links. Some even found the opposite results. In one study, MTHFR variants were linked to a lower risk of death from heart disease [R, R, R, R, R]
To celebrate the richness of this season, we've compiled the most powerful insights and the unforgettable moments into a special "Best of Season 3" episode. From experts breaking down complex health subjects to invaluable pieces of advice on achieving your healthiest self, this episode is your ultimate guide to the knowledge treasure of Season 3.
Is anxiety truly genetic? How do our genes and environment shape our response to stress? Are we all experiencing the world differently based on our unique biochemical make-up?
In this episode, Joe and Dr. Greg (SelfDecode Health Expert) dive deep into the realm of anxiety, answering questions from the SelfDecode community and unmasking the role our brain's biochemistry plays in the expression of anxiety.
Joe and Greg discuss the role of mental health in overall wellness and highlight specific genes that you can look at to potentially help you get rid of anxiety.
They then focus on the nutrients most commonly depleted under chronic stress and their links to anxiety, and break down some herbal supplements that work wonders in balancing our brain's neurotransmitters.
From the influence of specific genes like COMT and MTHFR, to the vital role of minerals like magnesium, zinc, and vitamin B6, this episode is a deep dive into the science of anxiety!
What’s the difference between genomics and genetics? How important is it to understand your genes when looking at optimizing your health?
In this episode, Dr. Anil Bajnath and Joe delve into the world of DNA and their impact on our health. Dr. Bajnath breaks down complex health science concepts in a way that's easy to understand, while sharing his unique approach to healthcare.
Some highlights of the episode include:
✔️ Understanding the difference between genomics (the study of all genes in our body) and genetics (the study of inherited traits).
✔️ The role of transcriptomics (how our genes behave) in understanding health issues like PTSD.
✔️ The impact of our gut health on our overall wellbeing.
✔️ The potential dangers of over-reliance on certain medications like statins.
✔️ The relevance of understanding lipid dynamics (how fat works in our bodies) for our heart health.
✔️ The value of a holistic approach to healthcare - focusing on treating the whole person, not just symptoms.
Dr. Anil Bajnath is a Board-Certified Family Physician. Author of The Longevity Equation: The Step-By-Step Blueprint to Hack Your Genes, Optimize Your Health, And Master the Art of Existence. Dr.Bajnath currently serves as Adjunct Faculty with the Department of Clinical Research and Leadership at George Washington University School of Medicine. He is the CEO and founder of the Institute for Human Optimization Precision Medicine Research Group located in Annapolis, Maryland.
Are supplements as strong as drugs?
Dr. Tyler Panzner is this episode's guest, bringing his expertise on the role of genetics and supplements in combating common ailments such as IBS, anxiety, and insomnia.
As a champion for understanding our body’s pathways, Dr. Panzner's approach is transforming our understanding of chronic disease and health management.
Dr. Panzner dives deep into the crucial topic of understanding and supporting our body’s most commonly mutated pathways, rather than getting caught up in an endless cycle of supplementing every gene.
He also provides an exciting viewpoint, comparing gene mutations and their effects across all cells in the body.
Joe and Tyler also point out the potential risks associated with the use of supplements and discuss the importance of understanding how they affect our bodies.
Dr. Tyler Panzner is a Ph.D. scientist trained in pharmacology, cancer, neuroscience, and inflammation research who has had a lifelong passion for understanding how substances affect the body. While his scientific training spans well over a decade, his passion for genetics and personalized medicine started ~6 years ago and he's pursued his goal of personalizing vitamin, supplement, and lifestyle regimes for each individual.
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Vince Giuliano is back, and this time, he’s discovered something about aging that may blow your mind.
Vince Giuliano is living a healthy and active life at the young age of 93, and is committed to continue doing research on longevity and increasing lifespan even at this age!
In this episode, Vince Giuliano and Joe discuss how supplements truly affect aging and how Vince has changed his perspective on longevity and the factors that affect it.
Vince talks about his new theory, which compares the human body to a computer system, and shares how you can hack your body from the “virus” that is aging and live a healthy and optimal life at an old age.
Vince Giuliano was a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and COO of Mirror Systems, a software company, and an international Internet consultant. In various ways, he contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s, and is now engaged in doing the same for The Longevity Revolution. He has published over 200 books and papers as well as over 430 substantive entries in his blog.
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In this episode, Joe sits down with biohacker and health expert, Anthony DiClementi.
Best known for his revolutionary work in the biohacking space, Anthony shares a wealth of knowledge drawn from his 20+ years of experience biohacking himself and his clients with biohackingcoach.com.
Anthony highlights the surprising, often overlooked factors contributing to bad health in the US, particularly focusing on the hidden toxins in our foods, the way cities are built, and the culture surrounding social interactions.
This engaging conversation also delves into the dichotomy of medical practice and nutritional wellness, highlighting how conventional treatments often fail to address core health issues.
Joe and Anthony also discuss the importance of genetics in understanding sensitivities to environmental toxins, and discuss the current landscape of DNA companies.
This episode of The Joe Cohen Show is a must-watch if you're looking to enhance your understanding of the unseen triggers impacting your health and wellness, and what you can do to completely optimize your health.
In this episode of The Joe Cohen Show, Joe sits down with Chief Scientific Officer of MitoQ, Dr. Siobhan Mitchell. Siobhan shares her impressive academic and industry experience and knowledge to explore mood, cognitive function, and mitochondrial health.
Her industry experience includes giants like Unilever, Nestle, PepsiCo, and Noom, where she worked on the fascinating effects of nutrition on mood and cognition.
Siobhan and Joe do a deep dive into the serotonin-mood connection, helping us understand the genetic risk factors for depression and anxiety.
Siobhan also shines a light on the underestimated significance of brain energy to mood and how mitochondrial strength plays a key role in this context. Siobhan also demystifies oxidative stress misconceptions and explains the impact of targeted antioxidants such as COQ10 and MitoQ.
Finally, we delve into the 'Ozempic' effect of fiber on our gut health and how it could suppress your appetite naturally.
Siobhan illustrates her firm belief that understanding the food we consume can prevent numerous diseases - truly, food is our medicine.
Explore these topics and much more as we discuss the human brain, mood, and the pioneering research in the field of mitochondrial health.
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Timestamps:
(0:00) - Intro
(1:31) - Serotonin & Mood
(12:56) - Brain Energy and mood
(16:53) - Oxidative Stress & Muscle Growth
(23:14) - Supplements that reach the brain
(28:51) - CBT, physiology, and mood
(32:00) - What are isoflavones?
(38:43) - Difference between SSRIs and Tryptophan or 5HTP
(50:04) - Brain energy and mitochondria health
(56:15) - Fiber, Butyrate, and the Ozempic Effect
(1:02:53) - Favorite probiotics
(1:04:14) - Deep dive into fish oils
(1:09:16) - Siobhan’s supplement stack
How can you use your biomarkers to create the optimal diet and supplement regimen for YOU? In this episode, Ari and Joe discuss how, similar to DNA, even optimal lab levels are personalized based on your unique body.
Ari talks about the problem with only focusing on 1 biomarker, and lets you in on important things to look out for when optimizing energy and focus.
They discuss the importance of AI and big data to health, and discuss the growing wearable market and how big of an impact this will have on optimizing health now and in the future.
Ari and Joe also discuss the importance of sleep and how it affects your recovery, and Ari shares his ultimate regimen for optimal sports performance.
Ari Tulla is a San Francisco-based entrepreneur and the co-founder & CEO of the smart nutrition service, Elo, whose mission is to transform food from the leading cause of disease to medicine. Ari is also an active angel investor and advisor with a portfolio of 40 startups, including Virta Health, Good Eggs, and Ōura.
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Timestamps:
(0:00) - Intro
(2:24) - Important biomarkers to test for
(10:33) - HbA1C and Glucose hacks
(29:40) - Homocysteine and the growing science behind it
(39:01) - Is there one blueprint for optimal health?
(46:50) - Sports performance vs. training for longevity
(1:02:13) - Sleep and HRV
(1:11:24) - The growth of health technology
(1:20:44) - Biological age tests
(1:26:55) - How to improve sleep
This episode was originally published on April 18th, 2017 on SelfHacked Radio - now known as The Joe Cohen Show.
It's been 6 years since this episode aired, and yet a lot of health issues that were mentioned, alongside revolutionary health strategies that Dr. Gundry shares, are still more relevant than ever!
In an episode that clearly shows Dr. Gundry was way ahead of his time, Joe and Steven Gundry discuss the prominence of leaky gut, how inflammation is the cause of the majority of health issues, and the root cause of all of this - LECTINS!
You'll also discover the best ways to approach an elimination diet and how to optimize your gut health!
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Timestamps:
(0:00) - Intro
(15:52) - Lectins number one cause of gut issues?
(22:15) - TH2 dominance and the immune system
(27:55) - The process of healing your gut to introduce more foods
(31:49) - Starting with a lectin-free diet
(34:17) - Fiberous carbs vs non-fiberous carbs
(44:17) - Low histamine foods relation to lectins
(48:00) - The cannabinoid system and the CNR1 Gene
(52:48) - Best probiotics to restore the gut
(55:52) - Most important supplements to take
(58:56) - Keto Plant Paradox
(1:01:47) - Animal protein and mTOR
Does a fast-mimicking diet give you the same benefits as a 5-day water fast?
How important is periodic fasting - also known as prolonged fasting - to your health? What is the best length of an intermittent fast?
In this episode of The Joe Cohen Show, we dive deep into the world of fasting with our guest Dr. Joseph Antoun from L-Nutra, the pioneering company behind the revolutionary fast-mimicking diet.
We discuss the science and mechanisms behind the fast-mimicking diet, exploring how it allows you to consume food and trick your body into thinking it’s fasting!
Dr. Antoun also shares his thoughts on the best time to stop eating, how long your intermittent fast should be, and how these practices can improve your longevity.
Dr. Joseph Antoun is CEO & Chairman of the Board of L-Nutra and Member of the Forbes Business Development Council. He's the former CEO of Health Systems Reform, a boutique consultancy aimed at improving public health by reforming health systems, management, and delivery.
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Timestamps:
(0:00) - Introduction
(1:48) - Longevity and fasting
(7:10) - Fasting by nourishment vs. deprivation
(13:06) - Periodic fasting vs. intermittent fasting
(15:41) - Eating while fasting
(21:37) - The structure of a fast mimicking diet
(25:03) - Mimicking an intermittent fast
(25:43) - The mechanisms behind fasting
Have you ever wondered what separates elite athletes and Navy SEALs from the rest of us? How do they optimize their physical and mental performance?
In this episode, Andrew Herr - who has led human performance and biotech strategy efforts for the U.S. military and ran R&D strategy efforts to get Navy SEALs ready to deploy - comes on the show to share his secrets to hack your recovery, improve your cognitive function, and optimize your stress management techniques.
Plus, Andrew talks about the biological causes of jet lag, and how you can solve jet lag in less than a day!
Some highlights of the episode include:
✔️ The one mistake even elite athletes make that might be wasting up to 50% of your workout value
✔️ Stress management techniques to improve your overall health
✔️ What supplements you can take to improve cognitive performance
✔️ The best thing you should focus on to enhance physical performance
Andrew is the Founder & CEO of Fount. Fount runs the most comprehensive and customized health and performance programs in the world and has discovered full solutions to challenges like jet lag and PMS. Over the past decade, Andrew led human performance and biotech strategy efforts for the U.S. military, from running R&D strategy efforts to getting Navy SEALs ready to deploy. This background has made him a trusted adviser to pro sports teams, leading corporations from tech to finance, and world class scientific institutions.
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Timestamps:
(0:00) - Intro
(1:53) - Andrew's journey with the Navy SEALs
(6:33) - Stress management techniques
(15:20) - Optimizing gut health
(28:26) - Thoughts on cholesterol
(36:18) - Improving cognitive performance
(38:15) - Improving physical performance
(43:46) - Optimal ApoB numbers
(48:27) - Solving jet lag
Is cholesterol good or bad for you? How should you treat your serum cholesterol levels in the blood? Is LDL-C the best marker to look at when analyzing your cardiovascular health?
In this episode, Joe dives deep into the complex and controversial world of cholesterol, examining the ongoing debate around its impact on cardiovascular health.
First, he breaks down the different viewpoints that dominate the topic of cholesterol, discussing the positives and negatives of each one. He also delves into various factors contributing to cardiovascular disease and how cholesterol fits into the bigger picture.
Then, he explores 10 lesser-known benefits of lipoproteins and cholesterol, including cellular repair, hormone production, mood improvement, and more. Joe explains the different markers we should consider when assessing cardiovascular risk, such as non-HDL Cholesterol, ApoB, and LDL particle size.
Finally, Joe shares his own experiences and offers his own approach on how to deal with cholesterol on a personalized level.
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Timestamps:
(0:00) - Introduction
(01:09) - The cholesterol wars
(02:55) - 10 Benefits of lipoproteins
(10:46) - The tricky issues of cholesterol
(18:11) - LDL, ApoB and Cardiovascular Disease
(22:30) - The increase in evidence since 2015
(25:25) - Does lower cholesterol always mean better?
(29:49) - Looking at the big picture
Do you ever feel like you're walking on a tightrope, unsure of what foods might trigger an unwanted reaction? Well, you're not alone.
Food sensitivities are more common than ever, and they can cause a whole host of issues ranging from digestive discomfort to brain fog.
After years of research and experimentation, and with the help of SelfDecode, Joe found what he think is a break through in reversing food sensitivities.
Now, he can eat things that he never thought possible a few years ago.
So he’s decided to share his journey and discoveries with you in this episode.
He dives deep into the world of food sensitivities, sharing some life-changing insights that equip you with the tools you need to overcome your own food sensitivities.
Some highlights of what you'll discover in this must-listen episode:
- The mechanics behind food sensitivities and how they affect your body
- Joes tried-and-tested top 5 hacks for improving food sensitivities (featuring some surprising nutrients you might not have considered!)
- The magic of butyrates and how they can transform your relationship with food
- The connection between tryptophan, ApoB, and your ability to enjoy a wider range of foods
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How important is it for you to test and track your lab markers? Are some tests more important than others? Are functional lab tests useless, or is it just the way that companies are interpreting the data that renders it useless?
In this eye-opening episode, we brought on Dr. Chris Masterjohn and Dr. Tommy Wood to dive deep into understanding the complexities of test results, vitamin and mineral deficiencies, and genetic predispositions.
Chris and Tommy use their years of expertise and tremendous depths of knowledge in the health space to discuss the issues with alternative health tests and the best ways to utilize your DNA results.
They also discuss the effects of deficiencies on essential nutrients like zinc and how you can take control of your well-being by identifying unique deficiencies about your own body.
Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health.
Dr. Tommy Wood is an MD with a Ph.D. in physiology and neuroscience. He has coached world-class athletes and is currently an Assistant Professor of Pediatrics and Neuroscience at the University of Washington.
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Timestamps:
(0:00) - Intro
(9:58) - Repeatability in testing
(18:28) - Validity of urine hormone testing
(31:00) - Chris’ thoughts on organic acids tests
(39:03) - Validity of organic acids tests
(43:52) - Fungal & yeast tests
(47:11) - Going over relevancy of some markers
(54:25) - Polygenic Risk Scoring
(1:00:47) - Nutritional Markers
(1:05:20) - Neurotransmitter Markers
(1:07:10) - Stool IgA Tests
(1:12:10) - Ion Amino Acids Panel
(1:16:51) - Summarizing functional lab tests
To celebrate the end of Season 2, we’ve gathered the top 10 moments of The Joe Cohen Show and compiled them into a single podcast episode!
These moments were voted on by Joe, employees of SelfDecode, and listeners of The Joe Cohen Show.
It includes clips filled with valuable knowledge on different health topics and actionable takeaways that you can implement in your daily life.
Full The Joe Cohen Show Episode links:
Stacy Sims
Dominik Nischwitz
Richard Miller
Molly Maloof
Chris Masterjohn
Alex Leaf
Jeffrey Gladden
Carrie Jones
Vince Giuliano
Tommy Wood
Timestamps:
(0:00) - Intro
(0:18) - Stacy Sims
(7:38) - Dominik Nischwitz
(13:50) - Richard Miller
(19:08) - Molly Maloof
(26:58) - Chris Masterjohn
(30:09) - Alex Leaf
(33:41) - Jeffrey Gladden
(42:04) - Carrie Jones
(47:45) - Vince Giuliano
(51:24) - Tommy Wood
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Longevity is a concoction of many different things - VO2 max, HRV, telomere length, blood pressure, mTOR and AMPK, and so much more. Optimizing and improving your lifespan requires a balanced focus on all of these through lifestyle, diet, and supplement implementations.
Dr. Jeffrey Gladden - a Board certified interventional cardiologist and the founder of Gladden Longevity - is the guest of today's episode!
We explore the different strategies that claim to improve longevity and dive deep into the science behind specific exercises, supplements, and drugs that improve lifespan.
Jeffrey talks about the ways to master your metabolism by utilizing the economy of balance concept, discusses all the different ‘biological ages’ that can be used to interpret our health, and gives his tip on the best way to increase VO2 max.
Dr. Jeffrey Gladden is a Board certified interventional cardiologist and the founder of Gladden Longevity, Human Performance & Longevity Optimization. He did his undergraduate work at Wheaton College and earned his Doctor of Medicine degree with Honors from Temple University in 1982. He has specialized in many areas of cardiology, including interventional, diagnostic, preventative, and programmatic.
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In our Health Analysis Series, Joe Cohen, expert biohacker and founder of SelfDecode, brings on a guest, and together they utilize the power of DNA and labs to assess, discuss, and recommend ways to further optimize their health.
Our guest today is Briana Theroux, a health professional certified by the Institute for the Psychology of Eating who has over a decade of experience biohacking her health.
In episode 2 of this 2 part series, Joe and Briana analyze her DNA results on SelfDecode, as well as her current and past lab markers.
They then discuss Briana’s current supplement stack, going in-depth on why each supplement is chosen and how it impacts her health.
Finally, they discuss ways that they can further optimize her health based on her genetic predispositions and lab markers - giving you the perfect outline on how you should approach your health!
This is the final episode of our Health Analysis Series.
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In our Health Analysis Series, Joe Cohen, expert biohacker and founder of SelfDecode, brings on a guest, and together they utilize the power of DNA and labs to assess, discuss, and recommend ways to further optimize their health.
Our guest today is Briana Theroux, a health professional certified by the Institute for the Psychology of Eating who has over a decade of experience biohacking her health.
In episode 1 of this 3 part series, Briana goes over her health history, discusses some of the game-changing supplements and lifestyle changes she has done to overcome her health issues, and dives deep into some tips and tricks for biohacking as a woman.
This episode provides the foundation for the next 2 episodes, where Joe and Briana look at genetic predispositions and lab levels to brainstorm the next steps to optimal health.
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Biological age is a critical indicator of our overall health and wellness. It's a measure of how well our body functions compared to others of the same chronological age.
But are all biological age tests the same? Are some more accurate indicators than other?
In this episode, Alex Leaf and I discuss the lifestyle factors that contribute to biological aging, such as diet, exercise, and stress management, and how we can make changes to improve our health and wellbeing.
We also talk about body image and its connection to mental health, and Alex shares his thoughts on Agmatine as well as his top 10 supplements.
Alex Leaf, M.S., holds a master’s degree in nutrition from Bastyr University and has been writing about the science of nutrition, health, and fitness for over a decade. Currently, Alex is a content creator and research writer alongside Ari Whitten at The Energy Blueprint. Formerly, Alex was a senior researcher at Examine.com and teaching assistant for the University of Western States' Human Nutrition and Functional Medicine masters program.
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Optimal nutrition is different from person to person, and even moreso from sex to sex. Men and women have many physiological differences that can truly change how to approach your health and fitness.
Are cold plunges good for men and women? What about saunas?
Dr. Stacy Sims - a forward-thinking international exercise physiologist and nutrition scientist - is the guest of todays episode, and we explore the physiological differences between male and female bodies and reveal how you can optimize your nutrition and training based on your unique needs.
We dive deep into specific vitamins and minerals, the difference in heat retention and how that affects health, and we discuss whether some biohacking methods - like cold plunges and saunas - are more optimal for one sex.
Stacy Sims has directed research programs at Stanford, AUT University, and the University of Waikato, focusing on female athlete health and performance and pushing the dogma to improve research on all women. Her contributions to the international research environment and the sports nutrition industry has established a new niche in sports nutrition; and established her reputation as the expert in sex differences in training, nutrition, and health
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What are some steps that you can take to boost your immune system so that you can stop getting sick? What if you just started feeling some symptoms, are there specific supplements that will stop the sickness dead in its tracks?
Dr. Chris Masterjohn is back on the podcast to outline his Ultimate Cold Prevention Protocol!
In this episode, Chris and Joe go through all of Chris’ prevention protocol - starting with what to do to strengthen your immune system, to your action plan when you first experience the “suspicous sneeze”, to what different vitamins and minerals you should focus on when you’ve been infected.
Chris also discusses the importance of understanding scientific studies (it’s more than just looking at charts), the difference between focusing on deficiencies vs. optimization, and his thoughts on alternative health tests like organic acids and dutch tests.
Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health.
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Timestamps:
(0:00) - Introduction
(1:00) - Chris’ thoughts on functional tests
(23:52) - Deficiency vs. Optimization
(29:30) - The immune system
(35:34) - The cold prevention protocol
(41:58) - The importance of understanding studies
(44:53) - Explaining Vitamin D
(48:59) - Continuing the cold prevention protocol
(56:07) - Nutrients for immunity
(1:07) - Glutathione
What supplements should I take to improve my hormones? Is there an optimal balance of estrogen and progesterone? Is prolactin an important hormone for men?
Hormones are an extremely important part of optimizing your health, but the majority of people have no idea just how much of an impact they have on… well, everything.
An estimated 30% of women experience hormone imbalances, which can cause mental health issues, weight issues, fertility, and much more.
That is an absolutely insane number!
So, I brought on Dr. Carrie Jones for this podcast to discuss all things hormone health and the growing studies that are helping put the spotlight on this important health area.
In this episode, Carrie shares the best thing you can do to optimize your hormones (in her words: it’s not that sexy), and we dive into detail on the relationship between estrogen, progesterone, prolactin, cortisol, and more. We also discuss how these are important hormones to keep track of for men.
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Timestamps:
(0:00) - Introduction
(1:31) - The difference between men and women
(3:16) - How hormone cycle effects training
(9:00) - Immune system and estrogen
(12:41) - Estrogen and sleep
(21:06) - Blood tests for hormones
(30:31) - Cortisol, stress, and hormones
(37:14) - Dopamine and prolactin
(46:53) - How to optimize your hormones
(51:30) - The best way to check your labs
How important is oral health to your overall health? What are you really doing when you remove your wisdom teeth? Turns out, bad oral hygiene is linked to a lot of chronic diseases, like heart disease, metabolic issues, depression and anxiety, and so much more.
So how can you optimize your oral health? Dr. Dominik Nischwitz is on today’s episode to give you practical strategies that you can implement to improve your dental health and, through that, your overall health!
In this episode, Dr. Nischwitz discusses the importance of maintaining optimal health in the mouth and highlights the key nutrients that you need to keep your teeth and gums in the best shape possible.
He also shares tips to help with bad breath, whether you really need to floss, and if mouthwash is good or bad for you.
And finally, he reveals his three superhuman oral healthcare strategies to keep your mouth healthy.
Dr. Dominik Nischwitz is a dentist and naturopath, a world specialist in biological dentistry and ceramic implants and the current Vice-President of the International Society of Metal-free Implantology (ISMI). A pioneer in the field of holistic dentistry, Dr. Nischwitz regularly gives lectures around the world and has recently published his first book “IT´S ALL IN YOUR MOUTH" at Chelsea Green.
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Timestamps:
(0:00) - Introduction
(1:35) - The importance of oral hygiene
(15:52) - Improving teeth for the next generation
(18:12) - Important nutrients for good dental health
(26:25) - Dr. Dome’s Health Journey
(30:15) - Optimizing your mood using genetics
(34:40) - Circling back to dental health
(37:23) - How important is flossing?
(43:30) - Are mouthwashes good or bad?
(44:34) - The three superhuman oral healthcare strategies
(47:03) - The epidemic of bad breath and tongue diagnosis
(51:56) - 5 tips to help with bad breath
(57:22) - Dr. Dome’s thoughts on Niacin
(1:03:56) - The effects of antibiotics
(1:06:53) - The issues with cavitation - the silent inflammation
(1:10:26) - Thoughts on fluoride and dentist teeth cleaning
It’s hard to slow down when you’re dopamine-dominant. Being highly motivated, fast-paced, and competitive has many benefits, but how can you slow down when it starts negatively impacting your health? Kris Gethin is on the podcast today to answer that, and much more!
In this episode, Kris and Joe discuss their thoughts on stem cell therapy, how to choose what supplements to add and remove for optimal fitness, and how Kris uses biohacking to balance his training with his focus on living a long and healthy life.
Kris also gives us an inside look at his daily routine and what he focuses on to optimize his diet and nutrition, which has resulted in him achieving a glycan age of 26 at the current chronological age of 48!
Kris Gethin is the co-owner of KAGED supplements, co-owner of the Kris Gethin Gyms, owner of Kris Gethin coaching and a hybrid athlete. He is the former editor in chief of bbcom, former editor at large of FLEX and came 2nd in Natural World bodybuilding championships in 2006.
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Timestamps:
(0:00) - Introduction
(2:56) - Kris’ Daily Routine
(10:42) - How Kris chooses his supplements
(15:24) - HRV and training
(21:18) - The neurochemistry behind overtraining and mood
(26:13) - Kris labs and supplements
(31:34) - Stem cells
(33:50) - Longevity and bodybuilding
(42:36) - How to improve glycan age
(45:43) - Th1 vs Th2 and megadosing supplements
As more people start focusing on their health, personalized nutrition is growing.
But it’s important to make sure that you understand what personalized diets entail, and how you can take the right steps to build the best nutrition plan for you. The best person to help you get started? Dr. Chris Masterjohn, who earned his PhD in Nutritional Sciences in 2012 and has been deeply entrenched in the research for 20+ years!
In this episode, Chris Masterjohn and Joe discuss issues with the RDA (Recommended Dietary Allowance), the differences in how they tackle health issues that come their way, and Chris outlines the steps he takes to discover the best supplements that improve his overall health!
Chris talks about how his battle with mold toxicity, how he solved a twitching problem, and his current experiment with a supplement that he thinks will be game changing for his health.
Chris Masterjohn served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. In the fall of 2016, he made the decision to leave academia and pursue independent research, consulting, working on information products, collaborating on information and technology products, and producing tons of free content to help people gain better health.
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How important is mitochondrial function in increasing energy? Is intermittent fasting different for men and women? Is metabolic health being overlooked in the USA? In this episode, Dr. Molly Maloof and Joe discuss how important it is to focus on your mitochondrial health, and Molly gives her TOP suggestions to condition your mitochondria for optimal energy and health!
Molly talks about the epidemic that is metabolic diseases, and discusses the best way to structure your exercise schedule as a woman.
They also discuss the significance of continuous glucose monitors, what it means to have good lab levels, and specific biohacks to improve HRV.
Dr. Molly Maloof’s book THE SPARK FACTOR: The Secret To Supercharging Energy, Becoming Resilient, and Feeling Better Than Ever is on sale January 31st!
As a physician and Stanford lecturer, Dr. Molly Maloof has spent her career providing personalized medicine services to high-performing technology executives, billionaire investors, Silicon Valley entrepreneurs, and Academy Award-winning actors.
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Timestamps:
(0:00) - Introduction
(3:38) - Molly's daily routine & sleep schedule
(13:14) - Molly's supplement stack
(16:52) - Controversy surrounding IV NADs
(21:08) - Optimizing mitochondrial health
(29:51) - Oxytocin & human connection
(38:19) - Intermittent Fasting
(47:45) - CGMs and Hba1c
(1:01:14) - Optimizing exercise based on the menstrual cycle
(1:13:06) - What does it mean to have good lab levels?
(1:19:24) - The epidemic of metabolic diseases
(1:23:39) - Thoughts on psychedelics
(1:26:32) - Thoughts on Ketamine
(1:32:38) - Organic acids testing
(1:36:02) - Does Molly take Nootropics?
The longevity revolution is upon us, as more and more studies are being done to discover ways to increase lifespan. One of the strongest advocates of this revolution? Vince Giuliano, living a healthy and active life at the young age of 93!
In this episode, Vince Giuliano and Joe discuss how he’s made it into his 90s in tiptop shape, how he tackles health issues that come his way, and what he would have done differently if he can travel back in time.
Vince talks about how he got his HRV levels to outperform young and healthy athletes, and shares some of his favorite supplements - specifically one that he has been taking for nearly 40 years!
Vince also talks about non-supplemental ways that you can implement in your life to improve your health and increase your longevity.
Vince Giuliano was a university professor at the State University of New York, a senior consultant working in a variety of fields at Arthur D. Little, Inc., Chief Scientist and COO of Mirror Systems, a software company, and an international Internet consultant. In various ways, he contributed to the Computer Revolution starting in the 1950s and the Internet Revolution starting in the late 1980s, and is now engaged in doing the same for The Longevity Revolution. He has published over 200 books and papers as well as over 430 substantive entries in his blog.
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Timestamps:
(0:00) - Introduction
(4:29) - When did Vince start his longevity journey?
(5:33) - Vince’s supplement journey
(18:08) - What Vince would do differently
(22:40) - Thoughts on Rapamycin
(31:27) - HRV & Heart Rate
(33:00) - Near infrared devices
(36:48) - More on Vince’s Supplement
(45:04) - Vince’s Top 5 Supplements
How far along is the science of longevity, and are there already proven methods that can increase your lifespan? In this episode, Richard Miller and Joe discuss the massive strides that are happening in the longevity space, and Richard shares the six compounds that have very promising research backing their benefit in improving life expectancy!
Richard talks about the problem with certain scientific studies and gives his thoughts on the controversial calorie restriction & longevity debate.
They talk about all kinds of drugs, including rapamycin, acarbose, reservatrol, and more, and discuss the one OTC supplement that has positive effects on lifespan!
Richard Miler is a Professor of Pathology at the University of Michigan, and Director of the Michigan Glenn Center on Aging. He got his MD and PhD at Yale, did postdoctoral work at Harvard and Sloan-Kettering, and was on the faculty at Boston University until his move to Michigan in 1990.
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Joe and Dr. Tommy Wood go over the most popular alternative health tests to tell you which ones are worth it and which ones are not.
Joe and Tommy discuss microbiome tests, organic acid tests, heavy metal tests, and so much more! Plus, find out the one occasion the Dutch test is helpful according to Dr. Tommy.
Tommy also shares the difference between IgE vs IgG food sensitivity tests and which one you should stay away from. They discuss whether vitamins & minerals tests are reliable, and tell you the problem with the RDA.
Find out what Tommy thinks about DNA tests, and why you shouldn’t try a health intervention based on a single SNP. Plus, Joe and Tommy discuss what’s the best approach when it comes to using genetic testing for health (spoiler: It’s polygenic risk scoring).
Dr. Tommy Wood is an MD with a Ph.D. in physiology and neuroscience. He has coached world-class athletes and is currently an Assistant Professor of Pediatrics and Neuroscience at the University of Washington.
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Find out Joe’s final 9 best supplements to improve mood! In this episode, Joe concludes his mood regimen of 18 supplements. Discover which supplements he’s been taking for years, and which two he’s thinking of removing from his regimen and why.
Joe talks all about betaine, vitamin B12, L-theanine, and more, and shares how he analyzes his personal health data (including family history, lifestyle, and predispositions) to decide which supplements to take and their dosages.
Joe also talks about why he cares about kidney health, and why you should too (spoiler: 90% of people who have kidney disease don’t know they have it). Plus, find out which mood supplement can surprisingly help with gray hair!
Listen to Parts 1 and 2 to discover 9 more supplements that are part of Joe’s mood regimen!
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What does a biohacker and a chef have in common? It may surprise you! In this episode, Joe continues to go through the supplements in his mood toolkit. He discusses 6 of his favorite supplements for mood, their mechanisms of actions, and effects. Plus, find out which supplement Joe would take if he couldn’t take 5-HTP.
He explains why finding out he had a zinc deficiency was a game-changer for his health and mood, the benefits of a zinc supplement, and what you need to look out for to see if you need more of this essential nutrient.
Learn more about the pros and cons of methylfolate, how to know how much you should take, and the surprising effects it has on fasting.
Joe also talks about one of the biggest mistakes he did in the beginning of his health journey, and why he’s commited to doing research and experiments with all supplements in his regimen.
Learn all about rhodiola, lithium orotate, and more!
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Find out what’s in Joe’s mood toolkit! Joe Cohen has been doing health experiments on himself for over 20 years, and he’s finally sharing all his knowledge with you.
In this episode, Joe walks you through lifestyle changes and 3 of his favorite supplements for mood: 5-HTP, thiamine, and resistant starch & butyrate. He discusses his megadosing experiments, dosages, and his problem with the RDA.
He explains why he takes each supplement, the mechanisms of action of these supplements, and the effects they have on his mood. Plus, discover the one problem Joe has with resistant starch.
Find out how Joe determines if he’s deficient in a nutrient, and the importance of learning your genetic predispositions and tracking your labs when building your regimen.
Learn all about Joe’s favorite mood stabilizer supplements!
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Have you heard of scientific wellness? In this episode, Nathan Price and Joe discuss whether the conventional approach of using pharmaceuticals to treat chronic diseases is effective, or if a preventative approach to complex conditions such as cardiovascular disease and Alzheimer’s is the best choice.
Nathan explains how genes can help predict the success of lifestyle-based interventions and talks about the accuracy of polygenic risk scores vs single variants for disease prediction, and how genetics can be used in healthcare.
Nathan and Joe also talk about nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), DHEA, and other supplements. Plus, Nathan explains the controversy of choline, carnitine, and TMAO, and if you should be worried.
Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. He was named one of the 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine and was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine.
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Should you be scared of psychedelics? In this episode, Tim Gray and Joe talk about how to get more REM and deep sleep, and Tim discusses his experience with methylene blue. They talk about the pros and cons of alcohol and their experience with different psychedelics.
Tim shares his experience with conventional medicine, the top things he’s trying to optimize in his health and his strategies for kidney health, gut health, and more. He talks about how he used to track 35 biomarkers every day, and which ones he still continues to monitor.
They discuss methylation, the MTHFR gene & SNPs, and how genetics and your environment can affect your overall health and how you respond to supplements.
Tim Gray is the UK’s leading biohacker and the founder of the popular Health Optimisation Summit, The Biohacker London Meetup group, and London’s first private Hyperbaric Oxygen Clinic. He is dedicated health optimizing biohacker, a psychology specialist, entrepreneur, and global speaker.
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Are supplements a waste of time and money? In this episode, Shawn Wells and Joe discuss whether taking supplements every day is bad for your health, and Joe shares the one time a supplement caused his liver enzymes to spike (it’s not what you’d expect!).
Shawn talks about the problem with certain supplement companies and lets you in on important things to look out for when choosing a supplement. They talk about all kinds of supplements, including lipoic acid, dihydroberberine, paraxanthine, ergothioneine, NAD, and more, discussing their effects, dosages, and how they work in the body.
Shawn and Joe also discuss the importance of optimal mitochondria function and why you should pay attention to it, and Shawn shares his ultimate mitochondrial supplement stack.
Shawn Wells, MPH, LDN, RD, CISSN, FISSN, is the world’s leading nutrition biochemist and an expert on health optimization. He’s formulated over 700 supplements, foods, and beverages, and is the author of The Energy Formula.
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Do supplements work the same for everyone? In this episode, Lucas Aoun shares his favorite supplements to improve cognitive function and focus, and he and Joe dig deep into how these compounds work in the body, discussing the research, dosages, and what to look out for.
They discuss dopamine and the mechanisms behind dopamine supplements and share their different experiences experimenting with supplements. Plus, listen to the benefits of increasing dopamine levels steadily vs taking supplements that cause a spike.
Lucas and Joe also talk about how to optimize testosterone levels, what causes low testosterone, and Lucas shares one surprising hack to increase your testosterone levels. Plus, find out one health hack Joe coins as “bromeopathy”.
Lucas Aoun is the founder of Ergogenic Health and Australia's leading biohacker & men's health expert.
This interview is not intended as medical advice.
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Low carb? Keto? Low fat? Fasting? In this episode, Katie Wells and Joe talk about her experience with dieting, some of the benefits she gets from intermittent fasting, and they discuss the controversial topic of cholesterol (spoiler: lower is not necessarily better).
Katie shares some of her favorite health hacks, and they talk about how genetics can influence a person’s health and how to use this information to live optimally. They also discuss which and how to track labs, the importance of optimal vs normal ranges, and what Katie does to hack her sleep & mood.
Katie Wells is the founder and CEO of wellnessmama.com and wellnesse.com. A mom of 6, she took her health into her own hands and started researching to find the answers to her health struggles. She has written over 1,500 blog posts, 3 books, and was named one of the most influential people in health and wellness.
This interview is not intended as medical advice.
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Timestamps:
(0:00) - Introduction
(1:04) - How Katie got into health
(3:53) - The Personalized Health Podcast?
(4:57) - Shifting of health goals
(6:44) - Katie’s current health goals
(8:14) - Joe shares his health journey
(9:04) - What labs to track for anti-aging?
(10:32) - Alcohol and saturated fats affect on health
(12:31) - Katie Wells thoughts on LDL cholesterol
(13:24) - Over-dieting and under nourishing
(16:52) - Unsullied by paid sponsors
(17:18) - Megadosing and metabolic flexibility
(18:45) - Katies daily supplement intake & fasting
(20:01) - The mental and spiritual benefits of a long fast
(22:15) - Joe’s experience with fasting
(23:42) - What supplements does Katie take now?
(24:39) - Pregnenolone dosages & benefits
(25:40) - Nootropic stack for focus
(26:37) - Tips to improve sleep from Katie
(28:45) - Katie’s most successful health “experiments”
(30:09) - The importance of protein in your diet
(31:40) - The last time Katie changed her mind about a health topic
(32:42) - The best health hack Katie wished she found earlier
(34:52) - Katie’s top hacks to optimize mood
(36:36) - The difference between normal and optimal lab ranges
(37:45) - How using SelfDecode can help optimize your lab levels
(38:58) - The most interesting DNA discovery
(41:10) - Katie’s expectations on her life span
(43:15) - Characteristics that make you successful
Is high cholesterol really bad for you? In this episode, Joe and Siim Land discuss what causes high cholesterol, which biomarkers to track for longevity, and the biggest mistake people make when trying to lose weight.
Siim shares one surprising mineral that can help lower cholesterol and talks about how intermittent fasting helps his mental & physical performance. Then, Siim and Joe discuss a top supplement for longevity and healthspan.
Siim Land is a renowned public speaker and expert in biohacking, health optimization, and overall performance optimization. He is also the author of Metabolic Autophagy and The Immunity Fix with Dr. James Dinicolantonio.
This interview is not intended as medical advice.
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Timestamps:
(0:00) - Introduction
(0:41) - Why Siim Got Into Biohacking
(2:35) - What markers should you measure for longevity?
(8:28) - Taking blood tests every year to track improvements
(10:40) - The top supplement to improve longevity
(13:21) - Unsullied by paid sponsors
(13:47) - Cholesterol in the biohacking world
(14:49) - Intermittent fasting, fats, and lowering cholesterol
(17:30) - Zinc and Copper ratio
(18:53) - Does lower T3 contribute to high cholesterol?
(20:03) - One supplement with high evidence of increasing lifespan
(21:00) - What Siim tracks on a regular basis
(23:09) - Siim’s HRV numbers
(24:20) - How Siim improves mental performance
(26:51) - How Siim improves physical performance
(30:35) - The biggest mistake people make with fat loss
(35:21) - Genetics affect on portion control in diets
(37:06) - How often is Siim physically active per day?
(38:31) - How you process carbs differently based on your body composition
(41:00) - Sleephacking tips from Siim Land
(46:20) - Improving your immunity
Kiwi as a biohack for sleep? Bet you didn’t know that one! In this episode, Joe and Teemu Arina talk all about biohacking your sleep, low & high HRV ranges, why heart rate variability is important for your overall health, and discuss some of Teemu’s favorite biohacks for the body & brain.
Teemu tells Joe why he got into biohacking, his secret to handling stress, and what he thinks is the best approach to optimizing his mental and physical performance. He also gives you a glimpse of what his supplement stack looks like and lets you in on one of his favorite supplements.
Teemu Arina is a thriving speaker and the creator and organizer of the Biohacker Summit. He’s also the author of the Biohacker's Handbook: Upgrade Yourself and Unleash Your Inner Potential.
This interview is not intended as medical advice.
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Timestamps:
(0:00) - Introduction
(1:42) - How Teemu got into biohacking
(7:43) - Optimizing the physical to improve the mental
(10:10) - How to improve your creativity
(13:03) - Personalizing your biohacking tools
(21:18) - Unsullied by paid sponsors
(21:45) - What is HRV and how Teemu increase his HRV
(26:49) - What are Joe’s strategies for improving HRV
(32:54) - The strength of the mind and negative effects of measuring
(34:44) - How the environment affects your sleep quality
(36:38) - The best biohacks for sleep
(41:00) - Melatonin’s effect on the body
(42:51) - What supplements does Teemu take every day?
(45:41) - Discount code for Biohacker Summit
Are EMFs harmful? Should you wear sunscreen? In this episode, Joe and Dr. Joseph Mercola discuss these and other controversial topics within the health industry. Dive deep into the importance of sun exposure (it’s not just vitamin D), vegetable oils, and learn valuable insights to hack your diet.
Dr. Mercola shares his secret for better vitamin D levels, discusses the problems with linoleic acid and which foods to avoid, and talks about the one supplement he hasn’ttaken in 15 years. Plus, listen to the top mistakes people make when trying to biohack their health.
Dr. Mercola is a New York Times bestselling author and the founder of the natural health website Mercola.com, one of the world’s leading natural health website with millions of monthly visitors.
Timestamps:
(0:00) - Introduction
(2:27) - The importance of the sun and Vitamin D
(7:03) - Mendelian Randomization Studies with Vitamin D
(10:20) - Dr. Mercola & The New York Times
(11:45) - EMFs vs. Vaccines
(14:25) - Tracking the effects of EMFs, Vegetable Oil, and Vaccines
(15:32) - Unsullied by paid sponsors
(16:00) - How long do the effects of Vegetable Oil last?
(19:39) - The negative effects of Vegetable Oils
(21:40) - What does Linoleic Acid do to your body?
(26:34) - How Dr. Mercola changed his diet to remove vegetable oils and decrease linoleic acid
(32:23) - Why studies on Vegetable Oil make it seem less harmful
(34:06) - LDL Cholesterol levels
(37:33) - The top 5 worst things people are doing for their health
(44:37) - Iron, Ferritin, and Hemoglobin
This interview is not intended as medical advice.
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