SAGE Life & Biomedical Sciences: Recent Episodes
SAGE Publications Ltd.
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SAGE is a leading international publisher of journals, books, and electronic media for academic, educational, and professional markets with principal offices in Los Angeles, London, New Delhi, and Singapore.
Volume 26 Issue 1, February 2021Dave Pechter discusses the February SLAS Technology Special Collection AI in Process Automation with Guest Editor Cenk Undey (Amgen), which includes the following papers:
- Artificial Intelligence Effecting a Paradigm Shift in Drug Development by Masturah Bte Mohd Abdul Rashid
- Artificial Intelligence (AI) to the Rescue: Deploying Machine Learning to Bridge the Biorelevance Gap in Antioxidant Assaysby Sunday Olakunle Idowu and Amos Akintayo Fatokun
- Deep Learning and Computer Vision Strategies for Automated Gene Editing with a Single-Cell Electroporation Platform by Cesar Patino, Prithvijit Mukherjee, Vincent Lemaitre, et al.
SLAS Discovery 25.10 December 2020Rob Howes discusses the paper "High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2" with authors Meredith Gardner (Scripps Research) and Michael Farzan (Scripps Research).
This research is part of the December Special Issue, Drug Discovery Targeting COVID-19 with Associate Editor Tim Spicer.
Volume 25 Issue 6, December 2020Dave Pechter discusses the December SLAS Technology Special Collection Advances in Technology to Address COVID-19 with Associate Editor Pak Kin Wong (The Pennsylvania State University), which includes Professor Wong's review Advances in Viral Diagnostic Technologies for Combating COVID-19 and Future Pandemics.
Volume 25 Issue 5, June 2020
Dave Pechter discusses with Varun Bhaskar Kothamachu, Ph.D. (Head of Product, Digi.Bio) & Sabrina Zaini (Head of Operations, Digi.Bio) their featured research article, "Role of Digital Microfluidics in Enabling Access to Laboratory Automation and Making Biology Programmable."
SLAS Technology 25.4 August 2020
Dave Pechter discusses with Christian Heiss & Parastoo Azadi regarding the SLAS Technology Special Issue: Carbohydrate Structure Analysis: Methods and Applications.
Volume 25 Issue 6, July 2020
Podcast Editor Rob Howes discusses the SLAS Discovery 2020 July Special Issue with Guest Editors Davide Gianni and Stuart Farrow.
This Special Issue of SLAS Discovery presents the topic “Functional Genomics for Target Identification” and is focused on three strategic pillars that form the foundation of the functional genomics discipline. Articles span a variety of relevant topics, from the development of more translatable models of diseases to the creation of validated screening libraries, technologies and computational pipelines to perturb gene function and enable quantitative interpretation of screening outputs.
Volume 25 Issue 5, June 2020
Podcast Editor Rob Howes discusses the SLAS Discovery 2020 June Special Collection with SLAS Discovery Editorial Board Member Joseph G. McGivern. To read the editorial by Joseph G. McGivern and Mei Ding, click here.
This Special Collection of SLAS Discovery presents a special collection reflecting recent advances and continuing challenges in the development and application of assay technologies that are applicable to drug discovery for ion channel targets.
Two articles are discussed:
Traceable Impedance-Based Dispensing and Cloning of Living Single Cells: Single-cell cloning is essential in stem cell biology, cancer research, and biotechnology. Regulatory agencies now require an indisputable proof of clonality that current technologies do not readily provide. Here, we report a one-step cloning method using an engineered pipet combined with an impedance-based sensing tip. This technology permits the efficient and traceable isolation of living cells, stem cells, and cancer stem cells that can be individually expanded in culture and transplanted.
Impedance-Based Single-Cell Pipetting: Many biological methods are based on single-cell isolation. In single-cell line development, the gold standard involves the dilution of cells by means of a pipet. This process is time-consuming as it is repeated over several weeks to ensure clonality. Here, we report the modeling, designing, and testing of a disposable pipet tip integrating a cell sensor based on the Coulter principle. We investigate, test, and discuss the effects of design parameters on the sensor performances with an analytical model. We also describe a system that enables the dispensing of single cells using an instrumented pipet coupled with the sensing tip. Most importantly, this system allows the recording of an impedance trace to be used as proof of single-cell isolation. We assess the performances of the system with beads and cells. Finally, we show that the electrical detection has no effect on cell viability.
Link to journal articles:
Muller G.; Bonzon D.; Claudinot S.; et al. Traceable Impedance-Based Dispensing and Cloning of Living Single Cells
Bonzon D.; Muller G.; Bureau J.; et al. Impedance-Based Single-Cell Pipetting
Link to issue: http://journals.sagepub.com/toc/jlad/25/3
Robert M. Campbell, Ph.D., is Senior Research Advisor at Eli Lilly and Company in Indianapolis, IN, where he heads the Cancer Cell Growth and Epigenetics Group. Dr. Campbell has served as Editor-in-Chief of SLAS Discovery for the past 12 years, where he has been a vital leader to grow the journal and share its important content. In this podcast, Dr. Campbell talks with our SLAS Discovery Podcast Editor Rob Howes, Ph.D. (AstraZeneca Gothenburg, Sweden) to discuss his work with the journal, as well as a little history about SLAS and the journal, and to make a call to authors and readers about upcoming content and his interest to work with listeners to publish and share their work. For more about Dr. Bob Campbell, read his ELN member profile article, Drum Roll Please! For more information about the journal, visit the SLAS Discovery website or contact Dr. Campbell directly at editorcampbell@slas.org.
The clinical team attending to a patient upon a diagnosis is faced with two main questions: what treatment, and at what dose? Clinical trials’ results provide the basis for guidance and support for official protocols that clinicians use to base their decisions upon. However, individuals rarely demonstrate the reported response from relevant clinical trials, often the average from a group representing a population or subpopulation. The decision complexity increases with combination treatments where drugs administered together can interact with each other, which is often the case. Additionally, the individual’s response to the treatment varies over time with the changes in his or her condition, whether via the indication or physiology. In practice, the drug and the dose selection depend greatly on the medical protocol of the healthcare provider and the medical team’s experience. As such, the results are inherently varied and often suboptimal. Big data approaches have emerged as an excellent decision-making support tool, but their application is limited by multiple challenges, the main one being the availability of sufficiently big datasets with good quality, representative information. An alternative approach—phenotypic personalized medicine (PPM)—finds an appropriate drug combination (quadratic phenotypic optimization platform [QPOP]) and an appropriate dosing strategy over time (CURATE.AI) based on small data collected exclusively from the treated individual. PPM-based approaches have demonstrated superior results over the current standard of care. The side effects are limited while the desired output is maximized, which directly translates into improving the length and quality of individuals’ lives.
Link to journal article: https://journals.sagepub.com/doi/full/10.1177/2472630319890316
Link to issue: http://journals.sagepub.com/toc/jlad/25/2
Podcast Editor Rob Howes discusses the SLAS Discovery 2020 February Special Issue with Martin Main and Andrew Zhang. To read their article, click here.
Over the last decade, flexible analytical devices have received considerable attention in both academia and industry. Compared to conventional analytical devices which are generally made from rigid materials, such as silicon, glass, and plastics, flexible devices offer several unique advantages, such as simplified fabrication, lower costs, enhanced portability and disposability, and compliance to curved or deforming surfaces. For these reasons, flexible analytical devices are well suited for many diagnostic applications, including wearable and in vivo sensing, and point-of-care testing for disease detection and health monitoring. This special issue showcases a comprehensive review and exciting original research on topics ranging from wearable sensors for human motion monitoring and disease diagnosis, flexible electrochemical sensor arrays for human cell culture monitoring, paper-based sensors and immunoassays for diagnostic testing, a paper-based biological solar cell for power generation and storage, and a 3D printing strategy for rapid prototyping of flexible microfluidic devices.
Link to journal articles: http://journals.sagepub.com/toc/jlad/25/1
Dave Pechter discusses with Chao Li the article, "Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency."
Professors at Johns Hopkins University, Claire Hur and Deok-Ho Kim, discuss their paper, "Engineering Innovations for Fundamental Biology and Translational Medicine".
UCLA Professor, Dino Di Carlo, discusses his review paper, "Technologies for the Directed Evolution of Cell Therapies".
University of Kansas researchers Yangjie Wei and Nicholas Larson talk about how they used a steady-state/lifetime fluorescence-based, high-throughput platform to develop a general workflow for direct formulation optimization under analytically challenging but commercially relevant conditions.
In the November/December 2018 JDMS podcast, Associate Editor Sharlette Anderson and author Yosefa Pessin discuss her article "Use and Opportunities in CAAHEP-Accredited Programs"
To view this article, click here.
In the September/October 2018 JDMS podcast, Associate Editor Kathryn E. Zale and author Gill Harrison discuss her article "Can Teaching Ultrasound Ergonomics to Ultrasound Practitioners Reduce White Knuckles and Transducer Grip Force?"
To view this article, click here.
Guest Editor Richard M. Eglen of Corning Life Sciences (Tewksbury, MA, USA) talks about a new collection of reviews and original research reports that illustrate how the combination of human iPS cells and 3D cell culture technology provide powerful new approaches to the development of novel and more effective therapies. Free access to the published collection is sponsored by Corning Life Sciences.
In the July/August 2018 JDMS podcast, Associate Editor Sharlette Anderson and author Nicole Stigall discuss her article "Abdominal Adiposity Measured by Sonography as a Tool for Determining Disease Risk."
To view this article, click here.
Guest Editor James M. Gill, II, Ph.D., of BFL Consulting (Madison, CT) talks about how the October 2018 issue of SLAS Technology showcases life sciences researchers who are pioneering the use of powerful yet accessible and low-cost IoT technologies in their laboratories. Ten articles illustrate how IoT is being used to optimize factors such as throughput, cost, uptime and result quality.
In the May/June 2018 JDMS podcast, Associate Editor Kathryn E. Zale and author Pamela Foy discuss her article "Sonography and Women’s Health."
To view this article, click here.
UCLA’s Coleman Murray, Ph.D., talks about his contribution to the August 2018 special issue of SLAS Technology on Enabling Technology in Cell-Based Therapies by guest editor Chris Puleo and his associates at General Electric Global Research. Murray’s article illustrates an important example of how new technologies are changing automation and processing in cell therapy manufacturing.
In the March/April 2018 JDMS podcast, Associate Editor Kerry E. Weinberg and author Robert Sean Dima discuss his article "Feasibility of an Audit System for Canadian Sonographers in Generalist Ultrasound."
To view this article, click here.
In the January/February 2018 JDMS podcast, Associate Editor Phillip J. Bendick and author Ashley Barry discuss her article "Sonography’s Role in the Diagnosis of May–Thurner Syndrome."
To view this article, click here.
In the November/December 2017 JDMS podcast, Associate Editor Sharlette D. Anderson and author Jennifer E. Bagley discuss her article "The Use of Contrast-Enhanced Ultrasonography for the Characterization of Focal Liver Lesions."
To view this article, click here.
Guest Editor Anand D. Jeyasekharan, Ph.D., of the Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, talks about the SLAS Technology special issue on Quantitative Imaging in Life Sciences and Biomedical Research. His insight and the articles in this special issue offer a meaningful glimpse into the potential and applicability of quantitative imaging as life sciences and biomedical research move into an era of big data and high-content experiments.
Christian Pylatiuk, Prof. Dr. med., of the Karlsruhe Institute of Technology, Institute for Automation and Applied Informatics in Eggenstein-Leopoldshafen, Germany, discusses his new article, which describes a zebrafish embryo sorting system with two cameras and image processing based on template-matching algorithms.
Meet Elodie Sollier-Christen of Vortex Biosciences as she talks with SLAS Podcast Editor David Pechter about the groundbreaking technology that earned her the 2017 SLAS Innovation Award.
Listen to author Weian Zhao of the University of California, Irvine, as he talks about his new review article, which summarizes and analyzes representative emerging micro- and nanotechnologies and automated systems for bacterial ID/AST, including phenotypic and molecular methods; discusses representative point-of-care systems that integrate sample processing, fluid handling, and detection for rapid bacterial ID/AST; and highlights major challenges and potential future endeavors toward improving clinical outcomes.
Dr. Elzbieta Jastrzebska of Warsaw University of Technology (Poland) talks about how microsystems can be used to understand processes in heart tissue in detail and to test newly developed compounds applied in the treatment of cardiac diseases.
In the September/October 2017 JDMS podcast, Associate Editor Shawn Roll and author Cathie Scholl discuss the article "Barriers to Performing Ergonomic Scanning Techniques for Sonographers."
To view this article, click here.
In the July/August 2017 JDMS podcast, Associate Editor Derek Butler and author Michael Rampoldi discuss the article "The Role of Echocardiography in the Assessment of Ventricular Septal Rupture Postmyocardial Infarction."
To view this article, click here.
Dr. Amar Basu of Wayne State University talks with SLAS Technology Podcasts Editor David Pechter about his in-depth, two-part review on digital assays (partitioning statistics and digital PCR; digital protein and cell assays).
In the May/June 2017 JDMS podcast, Associate Editor Angela Butwin and author Jenny Sim discuss the article "Understanding Sonography Clinical Decision-Making Learning Through Student Voices."
To view this article, click here.
SLAS Technology 22.3 June 2017
Special issue guest editors Dean Ho, Ph.D. and Ali Zarrinpar, M.D., Ph.D. of the University of California, Los Angeles, talk about the state of personalized and precision medicine and the 11 reviews and reports that explore innovation from a cross section of the disciplines driving major advances in PPM.
SLAS Technology 22.2 April 2017
2016 SLAS Innovation Award Winner Shana O. Kelley talks about new solutions for faster bacterial identification and analysis, and recent advances in managing infectious disease by leveraging single-cell analysis, microfluidic concentration and detection strategies, and ultrasensitive readout mechanisms.
In the March/April 2017 JDMS podcast, Editor Kevin Evans and author Kevin Volz discuss the article, "Targeted Contrast-Enhanced Ultrasound for Inflammation Detection: A Review of Current Evidence."
To view this article, click here.
In the January/February 2017 JDMS podcast, Associate Editor Dora DiGiacinto and author Nelangi Pinto discuss the article, "Sonographer-Identified Barriers and Facilitators to Prenatal Screening for Congenital Heart Disease: A Mixed Methods Study."
To view this article, click here.
In the November/December 2016 JDMS podcast, Editor Kevin Evans and author Ashley McClure discuss the article, "Using High-Intensity Focused Ultrasound as a Means to Provide Targeted Drug Delivery: A Literature Review."
To view this article, click here.
In the September/October 2016 JDMS podcast, Editor Phil Bendick and author Garth Nanni discuss the article, "Decidualized Endometriosis: Case Study of a Rare Condition in a Rare Location."
To view this article, click here.
SLAS Technology 22.1 February 2017
From being able to move liquid with sound to dispense primary cells and DNA to microfluidic-based immunoassays, SLAS Technology Editor-in-Chief talks about the groundbreaking achievements reflected in the 2017 SLAS Technology Ten. This year’s highlighted papers push the envelope of what is possible with automation, integrating new functions into high-throughput sample preparation and screening to further drive efficiencies in research.
Author Alison Obergrussberger of Nanion Technologies in Munich, Germany, discusses a planar patch clamp system with modular design capable of recording up to 384 cells simultaneously, and explains how the module can be incorporated into different state-of-the-art pipetting robots for seamless integration into high-throughput screening processes.
Author Aman Russom of the KTH Royal Institute of Technology in Stockholm, Sweden, talks with JALA Podcasts Editor David Pechter about a point-of-care microfluidic device that combines sample preparation methods to perform sample-to-result analysis of large-volume (20 mL) biopsy model samples with staining of captured cells using centrifugal-paper microfluidic filtration.
In the July/August 2016 JDMS podcast, incoming Editor-In-Chief Kevan Evans and author Ted Scott discuss his article, "Screening for Congenital Heart Disease: Sonographic Features and Techniques for Prenatal Detection."
To view this article, click here.
| In the May/June 2016 JDMS podcast, Vascular Section Editor, Derek C. Butler, and author Joleen Duarte Rodriguez discuss her article, "Brachiocephalic Artery Disease Progression Resulting in Complex Steal Phenomena." To view this article, click here. |
Despite the hype and headlines, 3D printing truly is a paradigm shift in how life sciences research can be conducted. The August 2016 issue of JALA presents a special collection of manuscripts devoted to this timely topic. Learn more from collection organizers Jay Gill and Alden Hart.
In the March/April 2016 JDMS podcast, Obstetrics & Gynecology Section, Editor Karen Having and author Crista Podsadecki discuss her article, "Perineural (Tarlov) Cyst Imitating Complex Adnexal Cyst: A Sonographic and Magnetic Resonance Imaging Correlation."
To view this article, click here.
| Centrifugal microfluidics has experienced much growth in recent years, especially in applications such as lab-on-a-disc (LoD) diagnostics. The strength of LoD systems lies in their potential for development into integrated sample-to-answer analysis systems. Author Ling X. Kong talks about her review of technologies necessary to develop next gen systems, valving and other fluid-handling operations, and the future of LoD reagent storage, sample prep, nucleic acid amplification, and analyte detection strategies. |
| This special issue of JALA focuses on advancements that integrate automation and high-throughput into traditional and emerging imaging applications, including “Fully Automated One-Step Production of Functional 3D Tumor Spheroids for High-Content Screening.” Learn from the authors of this original research report in this JALA Podcast. |
| Featuring 22 original scientific reports, this special issue demonstrates how new capabilities of ADE are changing the way that science is done. Hear more about this special issue’s highlights in this second of two ADE podcasts. |
“ADE is not another evolutionary step in the lab. It is correctly described as truly revolutionary,” says Joe Olechno of Labcyte, lead guest editor for this special issue of JALA. Learn more about what ADE is and how it works in this first of two ADE podcasts.
| In the November/December 2015 JDMS podcast, Cardiac Section Editor, Jeffrey Hill and author Kelly Mumbert discuss her article, "Takotsubo: A Case Study of Broken Heart Syndrome." To view this article, click here. |
Stephen Hughes, PhD, of the United States Department of Agriculture (USDA), Agricultural Research Service (ARS), National Center for Agricultural Utilization Research (NCAUR), Renewable Product Technology Research Unit, in Peoria, IL, talks about his team’s groundbreaking achievements.
To view article, click here.
DIA Editor-in-Chief Dr. Stephen Spielberg and Pediatrics Section Editor Dr. Ronald Portman discuss the special section on pediatrics in the September 2015 issue of TIRS, highlighting the challenges and opportunities they have faced in their research.
Introduction to the Pediatrics Special Section: New Horizons in Pediatric Drug Development
For further reading, please see the following articles mentioned in this podcast and/or featured in the Pediatrics Special Section:
Applying Regulatory Science to Develop Safe and Effective Medicines for Neonates
Attention-Deficit Hyperactivity Disorder and Pharmacotherapy—Past, Present, and Future
Advancing Pediatric Psychiatry Research
Best Practice Recommendations Regarding the Assessment of Palatability and Swallowability in the Development of Oral Dosage Forms for Pediatric Patients
Regulatory and Funding Strategies to Develop a Safety Study of an Auditory Brainstem Implant in Young Children Who Are Deaf
Food and Drug Administration Requirements for Clinical Studies in Pediatric Patients
iCAN Providing a Voice for Children and Families in Pediatric Research
| JALA Podcast Editor, David Pechter, and authors Angelika Niemz and Jim Osborne, discuss the October Special Issue: In Vitro Diagnostic Technology Reviews from the Keck Graduate Institute School of Applied Life Sciences To view article, click here. |
| In the September/October 2015 JDMS podcast, Associate Editor, Dora DiGiacinto and Bob Scissons discuss his article, "Arterial Doppler Wave forms: The Confusion Continues" To view this article, click here. |
Deborah Driscoll and Ann Meeker-O’Connell have a discussion with TIRS Editor-in-Chief, Dr. Stephen Spielberg in this podcast.
Read the full article here.
The JALA Guest Editor, Xianting Ding, discusses the August Special Issue: New Developments in Biosensing Technologies.
In the July/August 2015 JDMS podcast, Vascular Section Editor, Derek C. Butler, BA, RVT, RDMS, RDCS and Amanda Sentz discuss her article, "The Role of CTA, MRA, and Sonography in Aortic Dissection."
Click here to read the article.
Dr Wendy Lipworth, Dr Ric Day and Dr Luann Van Campen discuss the ethical dimensions of policies on medicine development in this podcast, hosted by TIRS Editor-in-Chief Dr Stephen Spielberg.
Read full articles here.
In the May/June 2015 JDMS podcast, OBGYN Section Editor Karen Having, Dora DiGiacinto, and Jennifer Bagley discuss the article, "Bioeffects Reference Tool May Not Improve Sonographers’ Monitoring of Mechanical and Thermal Indices in Obstetric Sonography Examinations."
Read full article here.
In the March/April 2015 JDMS podcast, Editor Phil Bendick, Bethany C. Rogers, and Kelsy L. Merideth discuss the article, "Sonographic Detection of Mayer-Rokitansky-Küster-Hauser Syndrome."
Read the full article here.
JALA editor-in-chief Edward Kai-Hua Chow, PhD, of National University of Singapore, talks about JALA’s 20th year of publication and the significance of this first special issue of the year (organized by guest editors Dan Dongeun Huh of the University of Pennsylvania, Philadelphia, PA; and Deok-Ho Kim of the University of Washington, Seattle, WA). Hear about the ways this issue can benefit communities in pharmaceutical and toxicology research.
Click here to read articles.
In the January/February 2015 JDMS podcast, Editor Phil Bendick and Joy Guthrie discuss the special issue, which represents the culmination of two years of work by the first graduating class of the Sonography Research Institute.
Read the full articles here.
A conversation with Richard Penninger and Dr. Charles Limb about their study on perception of pure tones and iterated rippled noise for normal hearing and Cochlear Implant users.
Read the full article here.
This automated, integrated platform contains a droplet-based microfluidic sampling section and an optical fiber–based spectroscopy detection section. By manipulating droplets containing reagents at certain concentrations at different times, quantifiable measurements via absorption spectroscopy can be made in a simple, sensitive, and high-throughput manner.
Click here to read article abstract.
Medical communications departments are constantly evolving to keep up with the changing landscape of health care. DIA is proud to provide a forum for Medical Communications professionals at our annual Medical and Scientific Communications Annual Meeting, which just held its 25th anniversary event in 2014. To recognize the changes that have occurred within the medical communications field over the last 25 years, we were pleased to include a special section devoted to the Medical Communications Transformation in the November issue of TIRS. This podcast highlights several of the authors from that section discussing globalization and new media trends that influence medical information dissemination and the effect this is having on the emerging healthcare landscape.
To read the articles discussed in this podcast see below:
Article 1: Introduction to the Special Section on Medical Communications: Medical Communications Transformation Within the Emerging Health Care Landscape.
Article 2: Review of the Evolution of Medical Information in Light of Changes in the External Landscape.
Article 3: Medical Information Services: How Are We Trending?
Article 4: Serialization: Benefits Beyond Regulatory Compliance
Non-profit group TransCelerate BioPharma Inc. has brought together several working groups to identify more efficient and effective approaches to the process of new drug development. In this podcast, Dr. Stephen P Spielberg discusses efforts to improve monitoring of clinical trials with key contributors to the TransCelerate efforts. Participants are Nicole Sheetz, Advisor, Clinical Innovation and Implementation, Eli Lilly and Company, Brett Wilson, Associate Director, Central Clinical Services, R&D Operations, Bristol-Myers Squibb; and Mark Travers, Vice President, Head of Clinical Study Units, Clinical Sciences & Operations, Sanofi.
Read full article here.
An automated microfluidic platform with a portfolio of customized molecular assays can detect nucleic acids, proteins, and posttranslational modifications in single intact cells with >95% reduction in reagent requirement in less than 8 h.
Click here to read article abstract.
Cheap and simple: Whole blood spiked with target cells is incubated with (super-)paramagnetic microparticles that bind phenotypic markers on target cells. Under rotation, all cells sediment into a chamber located opposite a co-rotating magnet, and bead-bound target cells are deflected to a designated reservoir.
An easy-to-use, low-cost, low-energy way to fragment DNA: lateral cavity acoustic transducers (LCATs) in a microfluidic device. The LCATs cause microstreaming, which fragments DNA within the solution without any need for purification or downstream processing.
The JALA Ten annually showcases the top 10 technological breakthroughs across a spectrum of fields that demonstrate the progress that can be realized when top scientists and engineers combine forces with translationally minded clinicians and entrepreneurs.
This podcast discusses a research study among students on a health sciences center campus to determine if the students were able to identify whether certain types of content posted on a social media site violated HIPAA. Students could identify a HIPAA violation when it included patient names, medical record numbers or images of the patient, but they were unable to identify HIPAA violations in social media postings that included a place, a date, and a more subtle identifier such as obesity. Discussion focused on whether or not practicing sonographers were at risk for making the same errors, and future research for helping all health care workers learn about what constitutes a HIPAA violation on social media was suggested.
Read the full article here.
This podcast discusses an approach to teach fetal heart anatomy to sonographers using a combination of online tutorials and mastery learning concepts. This approach was found to be superior (a one-sigma effect) to conventional classroom instruction relying on didactic lectures. Students in the online learning group were better able to identify both normal and abnormal fetal heart structures. Discussion focused on the logistics of such an approach, the necessary infrastructure and support, and potential limitations.
Read the full article here.
JALA 19.5 October 2014
This report advocates the use of relative mixing index for use by the lab-on-a chip community fo quantifying mixing events. Several different mixing indices are reviewed and then experimentally verified, revealing that the relative mixing index is not affected by lighting conditions.
To view the article, click here.
A discussion of the consequences of mergers and acquisitions on medical product development times.
Read full article here.
Learn more about opportunities to publish with DIA, where to find author guidelines and how to submit your manuscript, from Judy Connors, DIA’s Associate Director, Editorial Services.
To view additional information about publishing with DIA, click here.
JALA 19.4 August 2014
A miniaturized array device called Vertical-I with its membrane oriented vertically in reference to the table surface finds a protein synthesis yield 144% higher than that of a horizontal device. Plus, β-glucuronidase reaches the synthesis yield plateau after 2 h versus 4 h. When clogging of membrane pores is confirmed, the Vertical-II is designed to fit into a standard 96-well plate holder, increasing protein expression 406% over the horizontal device and consuming 5 times fewer reagents than a commercial device.
To view the article, click here.
This podcast features Dr. J. Philip Kaiser discussing his recent paper Putative Mechanisms of Environmental Chemical-Induced Steatosis, published in vol. 31(6) of International Journal of Toxicology.
Read the full article here.
TIRS Statistics Editor Richard Zink and fellow Editorial Board member Rick Turner discuss January’s Special Issue on Statistics, and the future of statistics in drug development.
Read full article here.
A discussion with Dr. Anne Rowzee of the Center for Drug Evaluation and Research, US FDA about patient input into the design of studies of medicines for multiple sclerosis.
Read full article here.
From part one of the two-part JALA Special Issue on Advancements in Biomedical Micro/Nano Tools and Technology: three authors talk about metastatic dissemination and spread of malignant circulating tumor cells (CTCs) and how physical enrichment technologies may enable analysis of rare CTC phenotypes that may not be otherwise obtained.
A conversation with Dr. Lode Dewulf and Editor-in-Chief, Dr. Stephen P. Spielberg about Dr. Dewulf's article in Therapeutic Innovation & Regulatory Science, the official journal of the Drug Information Association, addressing therapeutics during pregnancy.
Read full article here.
This review highlights recent advances in multiplexed bioanalyses benefitting from microfluidic integration.
The series of manuscripts in the MMB4 DMS supplemental issue of Int J Toxicol provides a synopsis of the drug development strategy employed for the characterization of MMB4 DMS ranging from the actual manufacture of the test article to preclinical safety and efficacy studies.
Click here to read the full article.
Experiments with holographic polymer-dispersed liquid crystal (H-PDLC) gratings driven by surface acoustic waves (SAWs) exhibit switchable properties: the diffraction of the H-PDLC grating decreases and the transmission increases.
The extraction of specific analytes from biological samples is a ubiquitous process spanning many areas within the life sciences.
The authors preprocess each frame of a video sequence, then analyze the sequence frame by frame using a rotating-circle template with a block-matching algorithm, and estimate the rotation rate of the pigmented cells using a pixel-patch correlation.
Cell-based drug absorption assays are an essential component of ADME/Tox testing for lead compounds. In this report, Apparent Permeability (Papp) and Efflux data demonstrate how an automated procedure, when compared to manual processing, provides a method that is less variable and is capable of delivering a more accurate assessment of a compound’s absorption characteristics.
Aptamers are oligonucleotides that can bind to various nonnucleic acid molecular targets in a high affinity and specificity. As an emerging class of therapeutic agents, aptamers offer an unparalleled advantage over other classes of therapeutic agents: the possibility to rationally regulate the therapeutic activity of aptamers.
JALA celebrates part two of its two-part special issue on Robotics in Laboratory Automation by discussing one author's historical perspective on the genesis of today's automated laboratory.
The application of a positive pressure based Serial Sample Loading (SSL) system to load the series of sample plugs into the capillary is demonstrated along with the adaptability of the SSL system to generate sample plugs with a variety of volumes in a predictable manner.
An HTS compatible 3D cell culture platform is generated by chemically “welding” polystyrene scaffolds into standard 2D polystyrene 96-well plates. The variability of scaffolds is minimized by introducing automation into the fabrication process.
In this report, Apparent Permeability (Papp) and Efflux data demonstrate how an automated procedure, when compared to manual processing, provides a method that is less variable and is capable of delivering a more accurate assessment of a compound’s absorption characteristics.