The Bob Harrington Show: Recent Episodes
Medscape
The Bob Harrington Show is a podcast series of thoughtful interviews and discussions on topics at the core of cardiology and the practice of medicine.
The rejection by the ABMS of a certification board run by cardiologists prompted this discussion on how medical training should change and the best methods to assess clinical competency.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
New Cardiology Board Denied but 'Not Done With This Fight' https://www.medscape.com/viewarticle/new-cardiology-board-denied-not-done-this-fight-2025a10006j8
You may also like:
Hear Dr John Mandrola's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
A panel discussion of a Presidential Advisory from the American Heart Association that outlines the importance of funding for scientific research and the need for a robust National Institutes of Health.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
INCLUDE URLS and full titles for some of the pertinent studies cited.
You may also like:
Principles for the Future of Biomedical Research in the United States and Optimizing the National Institutes of Health: A Presidential Advisory From the American Heart Association
https://doi.org/10.1161/cir.0000000000001319
The Role of Public-Sector Research in the Discovery of Drugs and Vaccines."
https://www.nejm.org/doi/full/10.1056/NEJMsa1008268
Comparison of Research Spending on New Drug Approvals by the National Institutes of Health vs the Pharmaceutical Industry, 2010-2019
https://pubmed.ncbi.nlm.nih.gov/37115539/
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Drs Harrington and Gibson review their picks for the top cardiology trials of 2024 and look ahead to 2025, particularly what health topics may be prioritized by the new administration.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment https://www.medscape.com/author/bob-harrington
Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction (REDUCE AMI) https://www.nejm.org/doi/abs/10.1056/NEJMoa2401479
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes (BPROAD) https://doi.org/10.1056/nejmoa2412006
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis EARLY TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2405880
Asundexian versus Apixaban in Patients with Atrial Fibrillation (OCEANIC-AF) https://doi.org/10.1056/NEJMoa2407105
In the Wake of OCEANIC-AF, Is Equipoise Regarding Factor XI Inhibition Still Afloat? https://www.jacc.org/doi/10.1016/j.jacc.2024.10.105
Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial https://doi.org/10.1016/S0140-6736(24)00413-6
Preventive Coronary Stents: Not There Yet
https://www.medscape.com/viewarticle/preventive-coronary-stents-not-there-yet-2024a10006yr
Speech by Commissioner Robert M. Califf to the House of Medicine June 16, 2023
https://www.fda.gov/news-events/speeches-fda-officials/speech-commissioner-robert-m-califf-house-medicine-06162023
Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach
https://doi.org/10.1016/j.ijcard.2021.11.039
From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314
You may also like:
Hear John Mandrola, MD’s summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
A review paper prompted a discussion among cardiologists Bob Harrington, Manesh Patel, and Michael Gibson on whether the ST-segment elevation myocardial infarction paradigm needs an update.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314
Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012
Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440
Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039
Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014
TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466
Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986
Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772
A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015
A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
A review paper prompted a discussion among cardiologists Bob Harrington, Manesh Patel, and Michael Gibson on whether the ST-segment elevation myocardial infarction paradigm needs an update.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
From ST-Segment Elevation MI to Occlusion MI: The New Paradigm Shift in Acute Myocardial Infarction https://doi.org/10.1016/j.jacadv.2024.101314
Angiographic and Clinical Outcomes Among Patients With Acute Coronary Syndromes Presenting With Isolated Anterior ST-Segment Depression: A TRITON-TIMI 38 Substudy https://doi.org/10.1016/j.jcin.2010.05.012
Treatment Time and In-Hospital Mortality Among Patients With ST-Segment Elevation Myocardial Infarction, 2018-2021 https://jamanetwork.com/journals/jama/fullarticle/2798440
Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach https://doi.org/10.1016/j.ijcard.2021.11.039
Implantable Cardiac Alert System for Early Recognition of ST-Segment Elevation Myocardial Infarction https://doi.org/10.1016/j.jacc.2019.01.014
TIME Trial: Effect of Timing of Stem Cell Delivery Following ST-Elevation Myocardial Infarction on the Recovery of Global and Regional Left Ventricular Function: Final 2-Year Analysis https://doi.org/10.1161/CIRCRESAHA.117.311466
Early Versus Delayed Invasive Intervention in Acute Coronary Syndromes https://www.nejm.org/doi/full/10.1056/NEJMoa0807986
Translating AI for the Clinician https://doi.org/10.1001/jama.2024.21772
A Novel Breakthrough in Wrist-Worn Transdermal Troponin-I-Sensor Assessment for Acute Myocardial Infarction https://doi.org/10.1093/ehjdh/ztad015
A Phase 3 Study of Zalunfiban in Subjects With ST-elevation MI (CELEBRATE) https://clinicaltrials.gov/study/NCT04825743
Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (SOS-AMI) https://clinicaltrials.gov/study/NCT04957719
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Cardiologists Bob Harrington and Dhruv Kazi discuss the projected burden of cardiovascular disease in 2050, why it's not sustainable, and what can be done to prevent it.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
INCLUDE URLS and full titles for some of the pertinent studies cited.
Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050
https://doi.org/10.1161/CIR.0000000000001256
Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050
https://doi.org/10.1161/CIR.0000000000001258
Calculating the 30-day Survival Rate in Acute Myocardial Infarction: Should we Use the Treatment Chain or the Hospital Catchment Model?
https://doi.org/10.5301/heartint.5000238
Life's Essential 8: Updating and Enhancing the American Heart Association's Construct of Cardiovascular Health
https://doi.org/10.1161/CIR.0000000000001078
Current Trends in Hypertension Identification and Management: Insights from the National Health and Nutrition Examination Survey
https://doi.org/10.1161/JAHA.123.034322
Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic
https://doi.org/10.2337/dci22-0046
US Trends in Cholesterol Screening, Lipid Levels, and Lipid‐Lowering Medication Use in US Adults, 1999 to 2018
https://doi.org/10.1161/JAHA.122.028205
GLP-1 Receptor Agonist Discontinuation Among Patients With Obesity and/or Type 2 Diabetes
https://pubmed.ncbi.nlm.nih.gov/38787563
Health Care by Food
https://healthcarexfood.org/
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
news@medscape.net
Dr Bob Harrington interviews journalist Shelley Wood about her new book, "The Leap Year Gene of Kit McKinley," her creative process, and the difference between medical journalism and writing fiction.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
The Leap Year Gene of Kit McKinley
https://shelleywood.ca/the-leap-year-gene/
Tragedy and Hope Wrapped in a Medical Mystery: Abraham Verghese and The Covenant of Water https://www.medscape.com/viewarticle/991751
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Medical practices are increasingly being acquired by private equity. Bob Harrington discusses why and what the ramifications are with the authors and editorialist of a research paper on the private equity landscape in cardiology vs other specialties.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Private Equity Acquisitions of Outpatient Cardiology Practices in the United States, 2013-2023
https://doi.org/10.1016/j.jacc.2024.06.011
Private Equity in Cardiovascular Practice: Solution or Symptom?
https://doi.org/10.1016/j.jacc.2024.06.012
Evaluating Trends in Private Equity Ownership and Impacts on Health Outcomes, Costs, and Quality: Systematic Review
https://doi.org/10.1136/bmj-2023-075244
2020 American Heart Association and American College of Cardiology Consensus Conference on Professionalism and Ethics: A Consensus Conference Report
https://doi.org/10.1161/CIR.0000000000000963
You may also like:
Hear John Mandrola's, MD, summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Bob Harrington and Mitch Elkind discuss "food is medicine" initiatives and the challenges associated with conducting clinical trials.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Health Care by Food Initiative https://healthcarexfood.org/
2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association https://doi.org/10.1161/CIR.0000000000001031
Rockefeller Foundation Food is Medicine https://www.rockefellerfoundation.org/initiative/food-is-medicine/
Targeted Scientific Research Projects to Demonstrate Effectiveness of 'Food Is Medicine' in Health Care https://newsroom.heart.org/news/targeted-scientific-research-projects-to-demonstrate-effectiveness-of-food-is-medicine-in-health-care
Food Is Medicine: A Presidential Advisory From the American Heart Association https://doi.org/10.1161/CIR.0000000000001182
Medically Tailored Meal Delivery for Diabetes Patients With Food Insecurity: a Randomized Cross-over Trial https://doi.org/10.1007/s11606-018-4716-z
'Food Is Medicine' Strategies for Nutrition Security and Cardiometabolic Health Equity: JACC State-of-the-Art Review https://doi.org/10.1016/j.jacc.2023.12.023
Current Landscape of Produce Prescription Programs in the US https://doi.org/10.1016/j.jneb.2022.02.011
Behavioral Nudges Are Used Widely to Steer Clinicians and Patients Alike https://doi.org/10.1056/CAT.23.0125
A Primary Care Agenda for Brain Health: A Scientific Statement From the American Heart Association https://www.ahajournals.org/doi/10.1161/STR.0000000000000367#
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Bob Harrington interviews fellow cardiologist Mike McConnell about his new book Fight Heart Disease Like Cancer and the need to model heart disease prevention and treatment after cancer.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Fight Heart Disease Like Cancer https://www.press.jhu.edu/books/title/12793/fight-heart-disease-cancer
PREVENT: AHA's New Risk Calculator Incorporates CKM Health https://www.medscape.com/viewarticle/998679
Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke https://doi.org/10.1136/bjo-2022-321842
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Cardiology researchers Bob Harrington and Bobby Yeh discuss how to do better observational research and the controversial notion of making causal inferences from such data.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
Academic Cardiology and Social Media https://doi.org/10.1161/CIRCOUTCOMES.118.004736
Bringing the Credibility Revolution to Observational Research and Cardiology https://doi.org/10.1161/CIRCULATIONAHA.123.064645
Cardio Twitter: An Essential Tool for Staying Current https://www.medscape.com/viewarticle/897512
Identification of Causal Effects Using Instrumental Variables https://doi.org/10.2307/2291629
Explaining Charter School Effectiveness https://www.aeaweb.org/articles?id=10.1257/app.5.4.1
Methods of Public Health Research - Strengthening Causal Inference from Observational Data https://doi.org/10.1056/NEJMp2113319
Publish or Perish and the Incentive for Quantity over Quality Research Papers https://www.medscape.com/viewarticle/998417
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Bob Harrington, Erin Michos, and Brahmajee Nallamothu discuss how the publish or perish culture can lead to sloppy research and the need for alternative models to measure success in academic medicine.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
With Great Power Comes Great Responsibility
Big Data Research From the National Inpatient Sample https://doi.org/10.1161/CIRCOUTCOMES.117.003846
Adherence to Methodological Standards in Research Using the National Inpatient Sample
https://doi.org/10.1001/jama.2017.17653
Publish or Perish: Where are we heading?
https://pubmed.ncbi.nlm.nih.gov/24778659
The Kardashian Index of Cardiologists: Celebrities or Experts? https://doi.org/10.1016/j.jaccas.2019.11.068
You may also like:
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Bob Harrington and Mike Gibson discuss two of the hottest topics in cardiology and medicine for 2023: a proposed alternative to the maintenance of certification process, and artificial intelligence.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Cardiovascular Organizations Pursue New, Independent Medical Board
https://www.acc.org/About-ACC/Press-Releases/2023/09/21/15/02/Cardiovascular-Organizations-Pursue-New-Independent-Medical-Board
The National Board of Physicians and Surgeons
https://nbpas.org/
Level of Scientific Evidence Underlying the Current American College of Cardiology/American Heart Association Clinical Practice Guidelines
https://doi.org/10.1161/CIRCOUTCOMES.118.005293
Validation of a Speech Analysis Application to Detect Worsening Heart Failure Events in Ambulatory Heart Failure Patients https://www.abstractsonline.com/pp8/?_ga=2.17782015.7532578.1693882428-1949139275.1663003561#!/10871/presentation/16568
A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models
https://doi.org/10.1016/j.jclinepi.2019.02.004
Recognizing a ruler instead of a cancer
https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/
The Geographic Bias in Medical AI Tools
https://hai.stanford.edu/news/geographic-bias-medical-ai-tools
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
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Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
news@medscape.net
For this year's review, Bob Harrington and Mike Gibson revisit the major cardiology conferences -- from ACC in New Orleans to AHA in Philly.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit:
https://www.medscape.com/author/bob-harrington
ACC 2023 Top Trials
-
Bempedoic Acid Cuts CV Events in Statin-Intolerant Patients: CLEAR Outcomes https://www.medscape.com/viewarticle/989100
-
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
-
Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616 https://www.jacc.org/doi/10.1016/j.jacc.2023.02.018
ACC/WCC 2023 Collection Page https://www.medscape.com/viewcollection/36966
ESC 2023 Top Trials
-
Wegovy Scores HFpEF Benefits in People With Obesity https://www.medscape.com/viewarticle/995844
-
Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity https://www.nejm.org/doi/full/10.1056/NEJMoa2306963
-
Acoramidis Shows Encouraging Results in ATTR Cardiomyopathy https://www.medscape.com/viewarticle/995883
ESC 2023 Collection Page https://www.medscape.com/viewcollection/36988
AHA 2023 Top Trials
-
Semaglutide 'A New Pathway' to CVD Risk Reduction: SELECT https://www.medscape.com/viewarticle/998373
-
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2307563
-
Bariatric Surgery is Associated With Improved Coronary Microvascular Function and Cardiorespiratory Fitness in Patients With Ischemia and Non-Obstructive Coronary Arteries https://www.ahajournals.org/doi/10.1161/circ.148.suppl_1.18949
-
Angioplasty Finally Proven Beneficial in Stable Angina: ORBITA-2 https://www.medscape.com/s/viewarticle/998375
-
A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina https://www.nejm.org/doi/full/10.1056/NEJMoa2310610
-
Impressive Bleeding Profile With Factor XI Inhibitor in AF: AZALEA https://www.medscape.com/viewarticle/998418
-
Promising First Results With DNA Editing to Lower LDL https://www.medscape.com/s/viewarticle/998719
-
Single Injection Reduces Blood Pressure for 6 Months: KARDIA-1 https://www.medscape.com/viewarticle/998666
AHA 2023 Collection Page https://www.medscape.com/viewcollection/37277
Other Mentions
-
N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects https://www.nejm.org/doi/full/10.1056/NEJMc2031173
-
Rimonabant: From RIO to Ban https://doi.org/10.1155%2F2011%2F432607
-
Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial https://doi.org/10.1016/S0140-6736(17)32714-9
-
Asundexian Phase 3 AF Study Halted for Lack of Efficacy https://www.medscape.com/viewarticle/998665
-
Challenges in the Design and Interpretation of Noninferiority Trials https://www.nejm.org/doi/full/10.1056/nejmra1510063
-
Milvexian for the Prevention of Venous Thromboembolism https://www.nejm.org/doi/full/10.1056/NEJMoa2113194
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Bob Harrington and Manesh Patel discuss sudden cardiac death in athletes and the importance of the chain of survival.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington
COVID and the Athlete's Heart
https://www.medscape.com/viewarticle/945282
Outcomes Registry for Cardiac Conditions in Athletes
https://doi.org/10.1161/JAHA.122.029052
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy
https://doi.org/10.1161/CIR.0000000000000937
Point-of-care screening for HFrEF using artificial intelligence during ECG-enabled stethoscope examination
https://doi.org/10.1016/s2589-7500(21)00256-9
International recommendations for electrocardiographic interpretation in athletes
https://doi.org/10.1093/eurheartj/ehw631
Elevation of Cardiac Troponins After Endurance Running Competitions
https://doi.org/10.1161/CIRCULATIONAHA.118.034655
Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy
https://doi.org/10.1001/jamacardio.2023.1042
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Preamble, Principles, and General Considerations
https://doi.org/10.1161/CIR.0000000000000236
RACE-CARS Trial
https://racecarstrial.org/
AHA CPR Resources
https://cpr.heart.org/en/cpr-courses-and-kits/hands-only-cpr
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
Bob Harrington interviews Jag Singh about the COVID journey that led to his book, Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington
Future Care: Sensors, Artificial Intelligence, and the Reinvention of Medicine. https://www.jagsinghmd.com/book
COVID-19 Hits Physician Couple: Dramatically Different Responses
https://www.medscape.com/viewarticle/928530
Smartwatch Electrocardiogram and Artificial Intelligence for Assessing Cardiac-Rhythm Safety of Drug Therapy in the COVID-19 Pandemic. The QT-logs study
https://doi.org/10.1016/j.ijcard.2021.01.002
The Care of the Patient
https://doi.org/10.1001/jama.1927.02680380001001
Advancements and future directions in the teamwork, targets, technology, and tight control-the 4T study: improving clinical outcomes in newly diagnosed pediatric type 1 diabetes
https://doi.org/10.1097/mop.0000000000001140
Social determinants of telemedicine utilization in ambulatory cardiovascular patients during the COVID-19 pandemic
https://doi.org/10.1093/ehjdh/ztab039
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact: news@medscape.net
Robert Harrington, MD and Jenine John, a cardiologist and machine learning research fellow discuss what you need to know about AI and ML in healthcare and where to find some helpful resources.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit: https://www.medscape.com/author/bob-harrington
'One Brave Idea' Recipient on Predicting Who Will Develop CAD
https://www.medscape.com/viewarticle/874536
Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection
https://doi.org/10.1161/circulationaha.121.058696
Application of Artificial Intelligence to the Electrocardiogram
https://doi.org/10.1093/eurheartj/ehab649
Using Machine Learning to Detect Problems in ECG Data Collection
https://www.cinc.org/archives/2011/pdf/0437.pdf
Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs
https://doi.org/10.1161/CIRCEP.119.007284
External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients
http://jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2021.2626
Sepsis Predictor Tool Falls Short in
Emergency Setting
https://www.medscape.com/viewarticle/982534
Dissecting Racial Bias in an Algorithm Used to Manage the Health of Populations
https://doi.org/10.1126/science.aax2342
Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms https://jamanetwork.com/journals/jama/fullarticle/2770833
Can Medical Algorithms Be Fair? Three Ethical Quandaries and One Dilemma
https://doi.org/10.1136/bmjhci-2021-100445
Healthcare Machine Learning: Getting Started
https://medium.com/@jeninej/healthcare-machine-learning-getting-started-761a7dbb63a2
What Clinicians Should Know About Healthcare AI, Part 1: Why Care About AI?
https://medium.com/@jeninej/what-clinicians-should-know-about-healthcare-ai-part-1-why-care-about-ai-aba6a06f696d
AI in Healthcare Specialization
https://www.coursera.org/specializations/ai-healthcare
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine: https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's, summary and perspective on the top cardiology news each week, on This Week in Cardiology: https://www.medscape.com/twic
Questions or feedback, please contact: news@medscape.net
Bob Harrington talks to two former colleagues who made a mid- and senior-career switch to pharma and digital tech, respectively. How did they make this decision and what advice do they have for others?
This podcast is intended for healthcare professionals only.
To read a transcript or to comment
https://www.medscape.com/author/bob-harrington
Jeff Bezos - Regret Minimization https://www.youtube.com/watch?v=-qPii5ACVYw
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Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
news@medscape.net
Trials on heart failure, hypertension and lipid-lowering drugs, and the evolution of antithrombin and antiplatelet therapy are discussed in part 2 of cardiologists Bob Harrington and Mike Gibson's annual review.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Lipid Lowering
Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure (STRONG-HF): A Multinational, Open-Label, Randomised, Trial
https://doi.org/10.1016/S0140-6736(22)02076-1
Why Combination Lipid-Lowering Therapy Should Be Considered Early in the Treatment of Elevated LDL-C for CV Risk Reduction
https://www.acc.org/latest-in-cardiology/articles/2022/06/01/12/11/why-combination-lipid-lowering-therapy-should-be-considered
Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs to Improve Statin Rates (NOTIFY-1 Project)
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062746
Equivalent Impact of Elevated Lipoprotein(a) and Familial Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease
https://doi.org/10.1016/j.jacc.2022.09.021
Comparative Effects of Low-Dose Rosuvastatin, Placebo and Dietary Supplements on Lipids and Inflammatory Biomarkers
https://doi.org/10.1016/j.jacc.2022.10.013
Antihypertensive Drugs
No Survival Advantage for Either Torsemide or Furosemide in HF: TRANSFORM-HF
https://www.medscape.com/viewarticle/983611
Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events
www.nejm.org/doi/full/10.1056/NEJMoa2212270
Antiplatelets
Duration of Antiplatelet Therapy After Complex Percutaneous Coronary Intervention in Patients at High Bleeding Risk: A MASTER DAPT Trial Sub-analysis
https://doi.org/10.1093/eurheartj/ehac284
PANTHER: Should Clopidogrel Become the 'New Aspirin' in CAD?
https://www.medscape.com/viewarticle/980117
P2Y12 Inhibitor Versus Aspirin Monotherapy for Secondary Prevention of Cardiovascular Events: Meta-analysis of Randomized Trials
https://doi.org/10.1093/ehjopen/oeac019
Ticagrelor Versus Clopidogrel in Patients With Acute Coronary Syndromes
https://doi.org/10.1056/nejmoa0904327
TCT-320 Pharmacokinetic and Pharmacodynamic Profile of PL-ASA, a Novel Phospholipid-Aspirin Complex Liquid Formulation, Compared to Enteric-Coated Aspirin at an 81-mg Dose – Results From a Prospective, Randomized, Crossover Study
https://www.jacc.org/doi/10.1016/j.jacc.2021.09.1173
Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation
https://europepmc.org/article/pmc/pmc8773391
Antithrombins/Factor XI
Rivaroxaban in Patients With a Recent Acute Coronary Syndrome
https://www.nejm.org/doi/full/10.1056/nejmoa1112277
Genetically Determined FXI (Factor XI) Levels and Risk of Stroke
https://doi.org/10.1161/strokeaha.118.022792
Factor XIa Inhibition With Asundexian After Acute Non-cardioembolic Ischaemic Stroke (PACIFIC-Stroke): an International, Randomised, Double-Blind, Placebo-Controlled, Phase 2b Trial
https://doi.org/10.1016/s0140-6736(22)01588-4
Safety of the Oral Factor Xia Inhibitor Asundexian Compared With Apixaban in Patients With Atrial Fibrillation (PACIFIC-AF): a Multicentre, Randomised, Double-Blind, Double-Dummy, Dose-Finding Phase 2 Study
https://doi.org/10.1016/S0140-6736(22)00456-1
A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction
https://doi.org/10.1161/circulationaha.122.061612
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https://www.medscape.com/twic
Questions or feedback? Please contact
news@medscape.net
In part 1 of their annual review, cardiologists Bob Harrington and Mike Gibson discuss in-person meetings, wearables and AI, COVID lessons for medical research, and the growth of RCTs from China.
This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
COVID Therapies
Therapeutic Anticoagulation With Heparin in Noncritically Ill Patients With Covid-19
https://www.nejm.org/doi/full/10.1056/NEJMoa2105911
Effect of Intermediate/High Versus Low Dose Heparin on the Thromboembolic and Hemorrhagic Risk of Unvaccinated COVID-19 Patients in the Emergency Department
https://doi.org/10.1186/s12873-022-00668-8
Two Old Meds and a DOAC a Bust Across Range of COVID Severity: The ACT Trials
https://www.medscape.com/viewarticle/980049
Effect of Ivermectin vs Placebo on Time to Sustained Recovery in Outpatients With Mild to Moderate COVID-19: A Randomized Clinical Trial
http://jamanetwork.com/article.aspx?doi=10.1001/jama.2022.18590
FDA Halts Use of Some COVID Monoclonal Antibodies Due to Omicron
https://www.medscape.com/viewarticle/967210
CT Surgeons Rise to Challenge, Lead Way in COVID Clinical Trials
https://www.sts.org/publications/sts-news/ct-surgeons-rise-challenge-lead-way-covid-clinical-trials
What Do We Know About Long COVID: A Cardiovascular Focus
https://www.medscape.com/viewarticle/981435
COVID-19 and the Heart: Is Cardiology Ready?
https://www.medscape.com/viewarticle/969206
The Stanford RECOVER Trial
https://recovercovid.org/
The Heroes Study
https://heroesresearch.org/
Artificial Intelligence
Age and Sex Estimation Using Artificial Intelligence From Standard 12-Lead ECGs
https://doi.org/10.1161/CIRCEP.119.007284
The Heartline Study
https://www.heartline.com/about
Evolution of Single-Lead ECG for STEMI Detection Using a Deep Learning Approach
https://doi.org/10.1016/j.ijcard.2021.11.039
Recognizing a Ruler Instead of a Cancer
https://menloml.com/2020/01/11/recognizing-a-ruler-instead-of-a-cancer/
Machine Learning Did Not Beat Logistic Regression in Time Series Prediction for Severe Asthma Exacerbations
https://doi.org/10.1038/s41598-022-24909-9
A Systematic Review Shows No Performance Benefit of Machine Learning Over Logistic Regression for Clinical Prediction Models
https://doi.org/10.1016/j.jclinepi.2019.02.004.
Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection
https://doi.org/10.1161/circulationaha.121.058696
Detection of Hypertrophic Cardiomyopathy Using a Convolutional Neural Network-Enabled Electrocardiogram
https://doi.org/10.1016/j.jacc.2019.12.030
Here's Why We're Not Prepared for the Next Wave of Biotech Innovation (by Matthew Herper)
https://www.statnews.com/2022/11/03/why-were-not-prepared-for-next-wave-of-biotech-innovation/
RCTs from China
Bivalirudin Plus a High-Dose Infusion Versus Heparin Monotherapy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Randomised Trial
https://doi.org/10.1016/S0140-6736(22)01999-7
Chinese Herbal Medicine May Offer Benefits in STEMI: CTS-AMI
https://www.medscape.com/viewarticle/983619
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https://www.medscape.com/twic
Questions or feedback? Please contact
news@medscape.net
Drs Bob Harrington and Betty Raman discuss the cardiovascular impact and long-term sequelae of COVID-19, the potential biology behind multisystem effects, and ongoing research.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Medium-term Effects of SARS-CoV-2 Infection on Multiple Vital Organs, Exercise Capacity, Cognition, Quality of Life and Mental Health, Post-Hospital Discharge
https://doi.org/10.1016/j.eclinm.2020.100683
Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection
https://doi.org/10.1016%2Fj.jacc.2020.06.007
Outcomes Among Confirmed Cases and a Matched Comparison Group in the Long-COVID in Scotland Study https://doi.org/10.1038/s41467-022-33415-5
Long COVID: Post-Acute Sequelae of COVID-19 With a Cardiovascular Focus
https://doi.org/10.1093/eurheartj/ehac031
Cardiovascular Disease and COVID-19: A Consensus Paper From the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in Collaboration With the European Heart Rhythm Association (EHRA)
https://doi.org/10.1093/cvr/cvab298
Infection of Brain Pericytes Underlying Neuropathology of COVID-19 Patients
https://doi.org/10.3390/ijms222111622
COVID-19 and Fat Embolism: A Hypothesis to Explain the Severe Clinical Outcome in people With Obesity
https://pubmed.ncbi.nlm.nih.gov/32514077
Association Between Epstein-Barr-Virus Reactivation and Development of Long-COVID Fatigue
https://doi.org/10.1111/all.15471
Activation or Exhaustion of CD8+ T Cells in Patients With COVID-19
https://doi.org/10.1038/s41423-021-00750-4
Skeletal Muscle Alterations in Patients With Acute COVID-19 and Post-Acute Sequelae of COVID-19
https://doi.org/10.1002/jcsm.12896
Gut Microbiota Dynamics in a Prospective Cohort of Patients With Post-Acute COVID-19 Syndrome
http://dx.doi.org/10.1136/gutjnl-2021-325989
COVID-Vaccine Myocarditis: Rare, Mild, and Usually a Guy Thing
https://www.medscape.com/viewarticle/966244
Myocardial Injury Pattern at MRI in COVID-19 Vaccine–Associated Myocarditis
https://doi.org/10.1148/radiol.212559
Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?
https://doi.org/10.3389/fimmu.2020.607734
Myocarditis Associated With COVID-19 Vaccination
https://doi.org/10.1161/CIRCIMAGING.121.013236
COVID and the Athlete's Heart
https://www.medscape.com/viewarticle/945282
COVID-19 and the Heart: Is Cardiology Ready?
https://www.medscape.com/viewarticle/969206
Lung Abnormalities Depicted With Hyperpolarized Xenon MRI in Patients With Long COVID
https://doi.org/10.1148/radiol.220069
Long COVID Resource Center
https://www.medscape.com/resource/long-covid
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Questions or feedback, please contact news@medscape.net
Do cardiologists from the AFFIRM generation treat AF less aggressively than the EAST-AFNET generation? Bob Harrington and Jonathan Piccini discuss this and upcoming trials on atrial fibrillation.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit:
https://www.medscape.com/author/bob-harrington
A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation (AFFIRM)
https://www.nejm.org/doi/full/10.1056/NEJMoa021328
Early Rhythm-Control Therapy in Patients with Atrial Fibrillation (EAST-AFNET 4)
https://www.nejm.org/doi/10.1056/NEJMoa2019422
Early AF Rhythm-Control Advantage Climbs With Comorbidity Burden: EAST-AFNET4
https://www.medscape.com/viewarticle/979627
Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB)
https://clinicaltrials.gov/ct2/show/NCT05130268
Generalizability of the EAST‐AFNET 4 Trial: Assessing Outcomes of Early Rhythm‐Control Therapy in Patients With Atrial Fibrillation
https://doi.org/10.1161/JAHA.121.024214
Early Rhythm Control Therapy for Atrial Fibrillation in Low-Risk Patients
A Nationwide Propensity Score–Weighted Study
https://doi.org/10.7326/M21-4798
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Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
news@medscape.net
Dr Bob Harrington talks with Drs Michelle Albert and Eldrin Lewis about the Association of Black Cardiologists' diversity scorecard for cardiovascular training programs.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit:
https://www.medscape.com/author/bob-harrington
The ABC Updates its CV DIBS Rankings | Association of Black Cardiologists
https://abcardio.org/recent-news/the-abc-updates-its-cv-dibs-rankings/
FDA Takes Important Steps to Increase Racial and Ethnic Diversity in Clinical Trials
https://www.fda.gov/news-events/press-announcements/fda-takes-important-steps-increase-racial-and-ethnic-diversity-clinical-trials
Gender Diversity in Cardiovascular Clinical Trial Research Begins at the Top
https://www.jacc.org/doi/abs/10.1016/j.jacc.2022.01.001
A Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops
https://www.nejm.org/doi/full/10.1056/NEJMoa1717250
At Black Barbershops, BP Reductions Still in Style at 1 Year
https://www.medscape.com/viewarticle/906724
Physician-Patient Racial Concordance and Disparities in Birthing Mortality for Newborns
https://doi.org/10.1073/pnas.1913405117
Racial and Ethnic Diversity at Medical Schools -- Why Aren't We There Yet?
https://www.nejm.org/doi/full/10.1056/NEJMp2105578
Medical School Enrollment More Diverse in 2021
https://www.aamc.org/news-insights/press-releases/medical-school-enrollment-more-diverse-2021#r
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https://www.medscape.com/twic
Questions or feedback, please contact:
news@medscape.net
Robert A. Harrington interviews LaShyra Nolen, a medical student and the 2021 recipient of the American Medical Student Association's Racial Justice in Medicine Award.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit:
https://www.medscape.com/author/bob-harrington
How Medical Education Is Missing the Bull's-eye
https://doi.org/10.1056/NEJMp1915891
This Is What I Want To Tell My White Professors When They Ask, 'How Are You Today?'
https://www.huffpost.com/entry/black-medical-student-wants-white-professors-to-know_n_5ed91238c5b6e0feefc26315
Statue of Controversial Surgeon to Be Moved From Central Park
https://www.medscape.com/viewarticle/891413
A Rift Over Carl Linnaeus Shows We Shouldn't Idolise Scientists
https://science.thewire.in/the-sciences/carl-linnaeus-entomological-society-of-america-great-man-theory-progress/
Running Away from Drapetomania: Samuel A. Cartwright, Medicine, and Race in the Antebellum South
https://muse.jhu.edu/article/699875
What Led Chicago to Shutter Dozens of Majority-Black Schools? Racism
https://www.theguardian.com/us-news/2018/dec/06/chicago-public-schools-closures-racism-ghosts-in-the-schoolyard-extract
Call to Action: Structural Racism as a Fundamental Driver of Health Disparities: A Presidential Advisory From the American Heart Association
https://doi.org/10.1161/CIR.0000000000000936
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https://www.medscape.com/twic
Questions or feedback, please contact: news@medscape.net
Bob Harrington interviews fellow cardiologist Jacqueline Tamis-Holland, vice chair of the recent ACC/AHA revascularization guidelines, who takes us inside the process.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization
https://doi.org/10.1016/j.jacc.2021.09.006
Evidence Based Medicine: What It Is and What It Isn't
https://doi.org/10.1136/bmj.312.7023.71
2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease:
https://doi.org/10.1161/CIR.0000000000000404
Ticagrelor With or Without Aspirin in High-Risk Patients After PCI
https://doi.org/10.1056/NEJMoa1908419
Surgical Groups Push Back Against New Revascularization Guidelines
https://www.medscape.com/viewarticle/966153
Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity
https://doi.org/10.1161/CIRCULATIONAHA.120.049755
The Invisible Hand — Medical Care During the Pandemic
https://www.nejm.org/doi/full/10.1056/NEJMp2006607
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https://www.medscape.com/twic
Questions or feedback, please contact
news@medscape.net
Robert Harrington, MD, interviews Ziyad Al-Aly, MD, about his recent paper in Nature Medicine focused on the long-term cardiovascular effects of COVID-19.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit
https://www.medscape.com/author/bob-harrington
Robert A. Harrington, MD, Arthur L. Bloomfield Professor; Chair, Department of Medicine, Stanford University; Chair, Department of Medicine, Stanford Medical Center, Stanford, California
Ziyad Al-Aly, MD, Chief of Research and Development, VA St. Louis Health Care System, St. Louis, Missouri
COVID-19 and Long-term Health
Long-Term Cardiovascular Outcomes of COVID-19 https://doi.org/10.1038/s41591-022-01689-3
High-Dimensional Characterization of Post-acute Sequelae of COVID-19
https://doi.org/10.1038/s41586-021-03553-9
Risks of Mental Health Outcomes in People With COVID-19: Cohort Study
https://doi.org/10.1136/bmj-2021-068993
Kidney Outcomes in Long COVID
https://doi.org/10.1681/ASN.2021060734
I'm 26. Coronavirus Sent Me to the Hospital.
https://www.nytimes.com/2020/03/23/opinion/coronavirus-young-people.html
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https://www.medscape.com/twic
Questions or feedback, please contact
news@medscape.net
Trials on lowering salt consumption and treating hypertension in the community impressed Drs Harrington and Gibson in this discussion of the best public health research of 2021.
This podcast is intended for healthcare professionals only.
To read a transcript or to comment, visit:
https://www.medscape.com/author/bob-harrington
CV Public Health Trials
Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS) https://doi.org/10.1016/j.ahj.2019.12.020
A Cluster Randomized Trial of a Village Doctor-Led Intervention on Blood Pressure Control: China Rural Hypertension Control Project
https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18155
A Remotely Delivered Hypertension and Lipid Program in 10,000 Patients Across a Diverse Health Care Network
https://www.abstractsonline.com/pp8/?_ga=2.141042993.2042594723.1635046736-1021258137.1633710264#!/9349/presentation/18153
COVID-19 Public Health Trials
Impact of community masking on COVID-19: A cluster-randomized trial in Bangladesh
https://www.poverty-action.org/publication/impact-community-masking-covid-19-cluster-randomized-trial-bangladesh
Dexamethasone in Hospitalized Patients with Covid-19
https://doi.org/10.1056/NEJMoa2021436
Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19
https://jamanetwork.com/journals/jama/fullarticle/2775280
The Recovery Trial Initiative
https://www.recoverytrial.net/results
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https://www.medscape.com/twic
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Drs Harrington and Gibson provide their annual roundup of what they consider the key cardiovascular trials of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit
This podcast is intended for US healthcare professionals only.
To read a full transcript of this episode or to comment please visit:
https://www.medscape.com/viewarticle/963475
https://www.medscape.com/author/bob-harrington
Antiplatelet Therapy
Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease
https://doi.org/10.1056/NEJMoa2102137
Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk
https://doi.org/10.1056/NEJMoa2108749
Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI
https://doi.org/10.1001/jama.2019.8145
Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Initiated, Prospective, Randomised, Open-Label, Multicentre Trial
https://doi.org/10.1016/S0140-6736(21)01063-1
SGLT2 Inhibitors and GLP-1 Agonists
Empagliflozin in Heart Failure with a Preserved Ejection Fraction
https://www.nejm.org/doi/full/10.1056/NEJMoa2107038
Once-Weekly Semaglutide in Adults with Overweight or Obesity
https://www.nejm.org/doi/full/10.1056/NEJMoa2032183
Cardiac Surgery and PCI
Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke
https://doi.org/10.1056/NEJMoa2101897
Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation
https://doi.org/10.1056/NEJMoa2115961
Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery
https://doi.org/10.1056/NEJMoa2112299
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Instead of trying therapies and hoping for the best, the RECOVERY trial investigators designed randomized trials to test which therapeutics were truly effective for COVID-19. Dr Harrington interviews lead investigator Martin Landray, MB ChB, PhD.
To read a transcript or to comment:
https://www.medscape.com/author/bob-harrington
The Bob Harrington Show is intended for healthcare professionals.
RECOVERY Trial Website and Some Publications
Randomized Evaluation of COVID-19 Therapy
https://www.recoverytrial.net/
Dexamethasone in Hospitalized Patients with Covid-19
https://www.nejm.org/doi/full/10.1056/nejmoa2021436
Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
https://doi.org/10.1016/S0140-6736(20)32013-4
Remdesivir for the Treatment of Covid-19 — Final Report https://www.nejm.org/doi/full/10.1056/nejmoa2007764
Dexamethasone in Hospitalized Patients with Covid-19 https://www.nejm.org/doi/full/10.1056/nejmoa2021436
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19
https://www.nejm.org/doi/full/10.1056/NEJMoa2022926
Clinical Trials and Informed Consent
The good Clinical Trials Collaborative
https://www.goodtrials.org/
Why do we need some large, simple randomized trials?
https://doi.org/10.1002/sim.4780030421
Assessment of Length and Readability of Informed Consent Documents for COVID-19 Vaccine Trials
http://jamanetwork.com/article.aspx?doi=10.1001/jamanetworkopen.2021.10843
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https://www.medscape.com/twic
Questions or feedback? Please contact:
news@medscape.net
A genomics giant with a family history of heart disease and an Olympic athlete accused of cheating are just two of the medical mysteries unraveled by DNA analysis. Bob Harrington interviews Euan Ashley, author of The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them (https://us.macmillan.com/books/9781250234995), who was inspired to write the book after watching an interview between "fellow nerds" Atul Gawande and Barack Obama. To read a transcript or to comment https://www.medscape.com/author/bob-harrington
The Book
The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them https://us.macmillan.com/books/9781250234995
The People
Stephen Quake
Clinical assessment incorporating a personal genome https://doi.org/10.1016/s0140-6736(10)60452-7
Leilani Graham https://www.leilanirgraham.com/
Eero Mäntyranta https://theolympians.co/2018/01/22/eero-mantyranta-the-ruddy-cheeks-and-the-genetic-advantange-of-a-cross-country-skiing-legend-from-finland/
You may also like:
Medscape Editor-in-Chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine
Hear Dr John Mandrola's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic
Questions or feedback, please contact news@medscape.net
What is the incidence of post-COVID myocarditis and when is it safe to return to play? Bob Harrington and Manesh Patel discuss our evolving understanding of how SARS-CoV-2 effects the hearts of athletes and weekend warriors. To read a transcript or to comment
https://www.medscape.com/author/bob-harrington
Early Studies
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) https://doi.org/10.1001/jamacardio.2020.3557
Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection https://doi.org/10.1001/jamacardio.2020.4916
Pooled autopsy https://www.medscape.com/viewarticle/944496
Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week
https://doi.org/10.1016/j.jacc.2020.11.031
Lake Louise Criteria https://pubmed.ncbi.nlm.nih.gov/30545455/
Recognition and Initial Management of Fulminant Myocarditis
A Scientific Statement From the American Heart Association
https://doi.org/10.1161/CIR.0000000000000745
Long-Haul Post–COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome: The Swedish Experience
https://doi.org/10.1016/j.jaccas.2021.01.009
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology
https://www.medscape.com/twic
Questions or feedback, please contact
news@medscape.net
Bob Harrington and Mike Gibson continue their review of 2020, discussing the 'riddle wrapped in an enigma' that was the COVID-19 pandemic.
The annual tradition continues as did cardiology research despite a pandemic. Trials on fish oils, statins, SGLT2 inhibitors, and antiplatelets are among the selections of Drs Harrington and Gibson.
Three editors of cardiology journals -- Drs Harrington, Yancy, and Nallamothu -- discuss the challenges of maintaining quality during the COVID-19 surge in submissions.
Hematologist Mary Cushman discusses arterial and venous thrombosis issues with SARS-CoV-2 and the role of anticoagulation.
Bob Harrington asks Michelle Albert why mortality rates are so high in minority communities, and whether COVID-19 will lead to meaningful changes in health and social inequities.
'They fancy themselves free. And no one will ever be free so long as there are pestilences,' wrote Camus in 'The Plague', which Abraham Verghese sees as relevant to our collective experience of COVID-19.
Cardiologist Lisa Rosenbaum seeks meaning in her work as a physician and correspondent for the New England Journal of Medicine, a quest first started by her grandfather who was also a physician-writer.
Bob Harrington and Mike Gibson continue their review of 2019 with the 'hottest trial of the year' and what to expect in healthcare in 2020.
'It's like we're in the '90s again.' Drs Gibson and Harrington review top cardiology trials on revascularization, lipid management, and antithrombotics in part 1 of their annual wrap-up.
A family history of sudden death was the impetus for author Sandeep Juahar's fascination with the heart, which led to a career in cardiology and his latest book Heart: A History.
Fewer black men are going into medicine today than in 1978. Drs Harrington and Capers discuss how to increase diversity in medicine and why it's important for caregivers to reflect the population they treat.
Optimal medical therapy and recent advances show that heart failure is preventable and not obligatory, Clyde Yancy tells Bob Harrington.
It's not all dire. Tait Shanafelt, MD, is witnessing improvement and momentum in the field of clinician wellness. Learn about his journey from hematology to chief wellness officer.
Volunteering at a VA hospital was the first step in biostatistician Frank Harrell's illustrious career in cardiovascular research.
Despite the vastness of available data, don't forget the basics, warns biostatistician Frank Harrell in this conversation with Bob Harrington.
Drs Harrington and Yeh discuss the pros, cons, and cautions of using Twitter in the cardiovascular community.
Drs Harrington and Joynt Maddox discuss the move from volume-based to performance-based payment models and how to develop evidence-based quality metrics that make clinical sense.
Drs Harrington and Gibson discuss burning issues in medicine, including artificial intelligence, social media, wearable tech, and the new hypertension guidelines.
Trials on PCSK9 inhibitors, antiplatelets, anticoagulants, and even catheter ablation of atrial fibrillation are among Drs Harrington and Gibson's picks for what to look for in 2018.
A recent viewpoint by Dr Bhatt against public reporting of PCI outcomes garnered a lot of support in the cardiology community and beyond. Dr Harrington asks how it can be done better.
In this annual tradition, Drs Harrington and Gibson discuss their picks for the top cardiology trials of the year, covering PCSK9 inhibitors, anti-inflammatory and anthithrombotic drugs, and PCI.
Drs Harrington and Kesselheim discuss the varied reasons why prescription drugs are so pricey and whether policies can interrupt this alarming trend.
Dr Califf talks about his new role at Verily and how data mining and data sharing could reduce disparities in care and improve patient outcomes.
From being critiqued by Bernie Sanders to the controversial Duchenne drug approval decision, Dr Califf recounts his experiences as FDA commissioner.
The Veterans Health Administration is the largest integrated healthcare system in the US with a common EHR. Dr Harrington learns the advantages for cardiology practice and research.
Why are only 13% of cardiologists women? Drs Harrington and Duvernoy discuss results from the recent ACC lifestyle survey and strategies for making cardiology 'a more human place.'
Drs Harrington and Douglas discuss pay disparities for women in cardiology and the importance of leveling the playing field.
Drs Harrington and Butte discuss the overwhelming amount of data generated in contemporary healthcare and how it can be harnessed to deliver precision medicine.
Drs Harrington and Gibson give their annual review of the highs and lows in medicine with a focus on cardiology.
Dr Harrington interviews Dr John Brush about his exploration of cognitive psychology (behavioral economics) and how it can improve physician decision-making.
Dr Harrington interviews HEAT-PPCI principal investigator Dr Rod Stables about engaging the hospital community in research and the benefits for all concerned.
No Luddite, Dr Wachter thinks digital medicine is a good thing if we can learn from aviation and develop technology that better serves patients and healthcare providers.
Drs Harrington and Hernandez discuss the limitations of randomized trials and the upcoming ADAPTABLE trial on aspirin dosing developed under the patient-centered-outcomes research initiative from NIH.
Euan Ashley, self-described geek-turned-cardiologist, discusses how big data can help you practice smarter medicine.
An architect of the Affordable Care Act on how his review of global health systems led him to the White House.
Dr. Harrington interviews Dr. Stephen Devries about integrative cardiology with a focus on nutrition.
Drs. Harrington and Ohman discuss the findings and agree to disagree on the ethics of delayed consent.
From the TCT tablet to reaching the full cardiovascular team, what does the future hold for major cardiology meetings?