NEJM This Week — Audio Summaries: Recent Episodes
The New England Journal of Medicine
The New England Journal of Medicine (NEJM) Weekly Audio Summary RSS feed. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.
This week, we feature new research on chronic kidney disease, high-risk prostate cancer, peripheral artery disease, and oxygen therapy after cardiac arrest. We review the evaluation and management of syncope, follow a challenging case of immune-related inflammatory illness, and report on Perspectives exploring pandemic preparedness, the Bundibugyo Ebola outbreak, and physician mental health.
This week, we feature advances that may change care for prostate cancer, multiple myeloma, acute pain, and IgA nephropathy. We review platelet factor 4 disorders and follow a case of persistent nasal ulceration. Perspectives explore medical aid in dying, federal authority in health care, public health and litigation, and the challenge of delivering life-changing news with honesty and compassion.
This week, we bring you advances in pancreatic and bladder cancer, preventing gonorrhea, a promising new therapy for adolescent hypertrophic cardiomyopathy, and a review of antiretroviral treatment for HIV. We also follow a striking case of vision loss that led to an unexpected diagnosis and discuss Perspectives on vaccine evidence, hepatitis C elimination, the endorsements of prescription drugs on social media, and the enduring intersection of love and loss in medicine.
This week, we present advances in the treatment of multiple myeloma, systemic lupus erythematosus, and coronary artery disease, alongside new national data on health care–associated infections. We also review fibromyalgia and the emerging Bundibugyo virus outbreak, follow a surprising diagnostic case of alpha-gal syndrome, and explore Perspectives on caring for vulnerable patients, trustworthy health information, pharmacotherapeutic decisions in autism care, and the experience of caring for a parent with dementia.
This week, we present advances in the treatment of idiopathic pulmonary fibrosis, hypothalamic obesity, and lung cancer. We review nutrition in critical illness and follow a diagnostic case involving a patient who had a lung transplant. The Editors warn about the politicization of science. We discuss the dead donor rule in an era of voluntary euthanasia. Perspectives explore the forthcoming crisis in long-term care, reproductive medicine, and the realities of caring for loved ones at the end of life.
This week, we discuss less-invasive approaches to guiding coronary intervention, new strategies for preventing kidney cancer recurrence, and head-to-head treatment data in multiple sclerosis. We review advances in multiple sclerosis, follow a diagnostic journey involving gait instability, and discuss correcting false narratives. Perspectives examine physicians and the body politic, chronic pain and OUD, and the often-overlooked burden of cognitive symptoms.
This week, we discuss a promising step toward a functional cure for chronic hepatitis B, first-line pulsed field ablation for persistent atrial fibrillation, reducing the demand for transfusion in surgery, treatment for rifampicin-resistant tuberculosis, and a decade-long look at CAR T-cell therapy outcomes. We review peanut allergy and discuss a case of a man with leg weakness, pain, and weight loss; Perspectives explore GLP-1 access, air-quality policy, and the human realities of homelessness.
This week, we discuss endovascular therapy for post-thrombotic syndrome, new evidence on prehospital blood transfusion strategies in trauma patients, and a trial of cefazolin for Staph. aureus bacteremia. We examine evolving approaches to thyroid cancer and share a case of a man with pancytopenia after heart transplantation. Perspectives explore psychedelic therapy, the convergence of Down syndrome and Alzheimer’s disease, and treating addiction.
This week, we present new evidence guiding coronary intervention, a molecular mechanism of inflammatory bowel disease, and gene therapy for a recessive disease. We review antidotes for anticoagulation reversal and discuss a case of hypertension in an adolescent patient. Perspectives examine cholera control, gambling-related harms, and race-based prescribing, alongside a reflection on medicine, motherhood, and what clinicians carry with them.
This week, we discuss left atrial appendage closure for atrial fibrillation, oxygen strategies in respiratory failure, an all-oral treatment for acute myeloid leukemia, CAR T-cell therapy enabling kidney transplantation, and a case of a neuroepithelial tumor that developed after gene therapy. We review childhood vaccine hesitancy, follow a complex diagnostic case, and examine Perspectives on corporatization in medicine, famine and war, and the future of health care systems.
This week, we present new research guiding treatment of pulmonary embolism, early progress in cardiac regeneration with engineered heart tissue, and treatments for gastroesophageal cancer and Chiari malformation. We review leishmaniasis and follow a revealing neurologic case. Perspectives discuss nutrition policy, tickborne illness, structural competence in medicine, and the arrival of closure.
This week, we present a promising new therapy for dermatomyositis, evolving approaches to stroke care, the prevention of Covid-19 after household exposure, and new treatments for kidney disease. We review inflammatory myopathies and follow a complex case of multisystem illness. Perspectives discuss AI and uncertainty in clinical care, health equity, the forces shaping affordability in health care, and on unpacking the ordinary.
This week, we present research on high-risk coronary intervention strategies, targeted therapy for pancreatic cancer, an mRNA influenza vaccine, and treatments for severe scabies and sickle cell disease. We review cerebral amyloid angiopathy and follow a complex case of a disseminated infection. Perspectives address the impact of corporate medicine on medical training and drug pricing policy.
This week, we feature advances in targeted therapy for HER2-mutant lung cancer, interventions to reduce maternal infection, an emerging treatment for hemophilia A, and a new diagnostic test for tuberculosis. We review Barrett’s esophagus and follow a case of systemic illness with kidney failure. Perspectives address GLP-1 drugs and eating disorders, directed blood donation, generic drug safety, and an in-flight medical emergency.
This week, we explore new strategies for blood-pressure control after intracerebral hemorrhage, Covid-19 treatment in higher-risk patients, hormonal therapy for prostate cancer, and anesthesia for tracheal intubation. We review spinal epidural abscess and follow a case of progressive weakness and liver lesions. We examine advances in tRNA research, and Perspectives discuss the use AI in prescribing, pediatric drug research, the impact of pharmaceutical mergers, and the goals of care.
This week, we present new research on stroke prevention, Kawasaki disease, ICU infection strategies, and immune thrombocytopenia. We review hormone therapy and thrombotic risk. A case highlights an evolving diagnosis of severe fatigue and sleep disturbance. Perspectives explore nursing workforce policy, the role of nurse scientists in rebuilding trust, and the health consequences of environmental rollbacks.
This week, we present new research on intensive LDL cholesterol targets, team-based strategies to improve blood pressure control, emerging therapies for immune and oncologic diseases, and a next-generation yellow fever vaccine. We review celiac disease and follow a compelling case of post-procedural complications. Perspectives explore health disparities and efforts to strengthen care in vulnerable communities.
This week, we present new research on treatment for muscle-invasive bladder cancer, left atrial appendage closure versus medical therapy for atrial fibrillation, gene-editing approaches for sickle cell disease and β-thalassemia, and the safety of discontinuing beta-blockers after myocardial infarction. We also review GLP-1 receptor agonists and discuss a Clinical Problem-Solving case of a man with progressive confusion. Perspectives explore corporatization; biologic, as opposed to chronologic, aging; and a legal case that could affect mental-health policy.
This week, we present new clinical trials on immunotherapy for stage III mismatch repair–deficient colon cancer, early surgery for asymptomatic aortic stenosis, an approach to dengue virus suppression, and advances in gene and prime-editing therapies for rare disorders. We also review minipuberty. We follow the case of a 12-year-old girl with altered mental status and persistent hypoglycemia, and we explore Perspectives on corporate influences on health, vaccine communication, antitrust policy, conflicts of interest, and the meaning of the number needed to treat.
This week, we explore new evidence comparing oral anticoagulants for acute venous thromboembolism, treatment for chemotherapy-induced thrombocytopenia, and early results of gene therapy for inherited deafness. We also examine evolving strategies for chronic lymphocytic leukemia, review the management of polymyalgia rheumatica, and present a case discussion of a woman with chest pain, dyspnea, and syncope. We explore gastric cancer prevention, competency-based billing, the health consequences of immigration enforcement, access to high-cost gene therapies, and we present a Perspective on good compressions.
This week, we explore a phase 3 trial of finerenone in type 1 diabetes and chronic kidney disease and guidance on timing of nonculprit-lesion PCI after STEMI. We cover an investigational therapy for Dravet syndrome and neoadjuvant treatment for high-risk intrahepatic cholangiocarcinoma. We review the effects of radiotherapy on normal tissue, a puzzling case of progressive neurologic decline after suspected foodborne illness, and Perspectives on private equity, the AHEAD model, and medical credit cards.
This week, we explore a new standard of care for high-risk HER2-positive early breast cancer, long-acting therapy for people with HIV facing adherence challenges, a first-in-class trial of a p53 reactivator, and tecovirimat for mpox. We review group B streptococcal disease and a revealing case of prosthetic joint infection. Perspectives examine the role of folate therapy, Medicare drug-price negotiation, AI in medical education, and incidental findings.
In this episode, we explore new treatments for hypertension, hereditary amyloidosis, and malaria prevention, along with insights on mosquito-borne disease control. We review idiopathic intracranial hypertension, follow a striking case of a hidden foreign body, and hear perspectives on worker safety, immigrant health care, the role of pharmaceutical wholesalers, and the arc of a medical career.
Featuring articles on severe acute malnutrition with gastroenteritis in children, medical imaging and pediatric cancer risk, moderate hypertriglyceridemia, preventing RSV disease in healthy infants, and treating hypertension in rural South Africa; a review article on monoclonal gammopathy of undetermined significance; a Clinical Problem-Solving on a shifting frame; and Perspectives on insight into corporate governance, on pharmaceutical tariffs, and on OUD medications.
Featuring articles on heart failure, provoked venous thromboembolism, chronic lymphocytic leukemia, and acute ischemic stroke; a review article on medical education to improve diagnostic equity; a case report of a man with embolic stroke and left ventricular apical aneurysm; two articles on the 2025 Lasker–DeBakey Clinical Medical Research Award; and Perspectives on structural and scientific racism, on the Gates Foundation’s final chapter, and on Dr. Kolhouse and the cowboy.
Featuring articles on PI3K-altered colorectal cancer, type 2 diabetes, oral semaglutide, and proportional-assist ventilation; a review article on tumor lysis syndrome; a case report of a girl with chest pain and bone and liver lesions; and Perspectives on integrating pharmacotherapy into tobacco control, on Medicaid enrollees with chronic conditions, and on ultraprocessed food.
Featuring articles on hypertrophic cardiomyopathy, rehabilitation after myocardial infarction in older adults, the 2024 Marburg virus disease outbreak in Rwanda, and medications for opioid use disorder in county jails; a case report of a woman with dyspnea and fatigue; a Medicine and Society on the race-correction debates; and Perspectives on recent efforts toward equity, on medical research funding in a divided America, and on the end of days.
Featuring articles on obesity, type 1 diabetes, syphilis, and heparin-induced thrombocytopenia; a review article on the management of acute type B aortic dissection; a Clinical Problem-Solving describing a fruitful workup; and Perspectives on the corporatization deal, on advancing physician-scientist training in China, and on the rise of drug innovation in China.
Featuring articles on lung cancer, vasomotor symptoms in breast cancer, autoimmune pulmonary alveolar proteinosis, and high-risk cutaneous squamous-cell carcinoma; a review article on educational strategies for clinical supervision of AI use; a case report of a woman with fatigue and myalgias; a Sounding Board on vaccine policy in the U.S.; and Perspectives on preventive care at the Supreme Court, regulating private equity in health care, reforming the prescription drug user fee program, and on the consultant.
Featuring articles on overweight, obesity and diabetes; lactated Ringer’s solution versus normal saline; and spinal muscular atrophy; a review article on metabolic dysfunction–associated steatotic liver disease; a case report of a woman with respiratory failure and abnormal chest imaging; and Perspectives on dismantling public health infrastructure, on progress lost, on private law in American health care, and on the serendipitous dance between life and death.
Featuring articles on treatments for chronic kidney disease and type 2 diabetes, bubonic plague, and advanced breast cancer; a review article on hypogonadism; a Clinical Problem-Solving describing gasping for strength; a Medicine and Society on the infant mortality rate; and Perspectives on profit-driven medicine, on lead contamination in Milwaukee schools, on training health communicators, and on ER and becoming a physician.
Featuring articles on myeloma, mitochondrial DNA disease, cardiac surgery, and squamous-cell carcinoma; a review article on motor vehicle crash prevention; a case report of a woman with seizure-like activity and odd behaviors; a Medicine and Society article on the evaluation of occupational pulmonary impairment; and Perspectives on Covid-19 vaccines, on public policies, and on living on the edge of the valley of the sick.
Featuring articles on type 2 diabetes, gastric cancer, lung cancer, and malaria; a review article on competency-based medical education; a case report of a man with cough, dyspnea, and hypoxemia; and Perspectives on brain death in pregnancy, on the Supreme Court’s failure to protect trans minors, on real-world data, and on avocado and salt.
Featuring articles on gastric and gastroesophageal junction cancer, pulmonary sarcoidosis, graft-versus-host disease, gastroenteritis in children, the rapid recovery of donor hearts after circulatory death, and an on-table reanimation of a pediatric heart from donation after circulatory death; a review article on fragile X disorders; a case report of a woman with neck swelling and dysphagia; and Perspectives on vaccine policy, on new mammography tools, and on the second life of Jacqui B.
Featuring articles on mild asthma, cardiovascular risk factors, stroke, advanced breast cancer, and transforming health care; a review article on juvenile idiopathic arthritis; a case report of a man with headache and ataxia; and Perspectives on who will care for America, on hospital financial assistance policies, and on libraries burned, and a life lived.
Featuring articles on structured exercise after chemotherapy for colon cancer, and treatments in obesity, in head and neck cancer, and in patients at high risk for cardiovascular events; a review article on forensic pathology; a Clinical Problem-Solving on caving in to pressure; a Sounding Board on climate change and human health; and Perspectives on the corporatization of U.S. health care, on self-neglect in older people, on Medicare drug price negotiation, and on the autopsy report.
Featuring articles on mismatch repair–deficient tumors, generalized myasthenia gravis, HER2-mutant non–small-cell lung cancer, a Corynebacterium diphtheriae outbreak, and hereditary and sporadic papillary kidney cancer; a review article on unruptured intracranial aneurysms; a case report of a man with respiratory failure and shock after kidney transplantation; and Perspectives on medical AI and clinician surveillance, on pathobiology, and on unrest.
Featuring articles on treatments for pulmonary fibrosis, for obesity and overweight, for severe hemophilia B, and for a rare genetic disease; a review article on malnutrition in older adults; a case report of a man with a nasopharyngeal mass; a Medicine and Society on John Collins Warren; and Perspectives on undermining women’s health research, on addressing antifungal drug resistance, and on conversations that matter in maternal medicine.
Featuring articles on metabolic dysfunction–associated steatohepatitis, lung nodules, breast cancer, and improving birth outcomes; a review article on hemoglobinopathies; a Clinical Problem-Solving on from where it stems; and Perspectives on U.S. research leadership at a crossroads, on health care in an evolving immigration landscape, and on carrying hope while facing a crisis.
Featuring articles on pulmonary arterial hypertension, oral semaglutide and cardiovascular outcomes, giant-cell arteritis, the loss of subsidized drug coverage and mortality, and neutralizing venom toxins; a review article on cancer of unknown primary site; a case report of a man with fever, nausea, and respiratory failure; and Perspectives on primary care and the free market, federal cuts at the VA, the GINA gap, and the meaning of goodbye.
Featuring articles on multiple sclerosis, narcolepsy type 1, antiretroviral therapy in children with HIV, and porcine kidney xenotransplantation; a review article on Ph-positive acute lymphoblastic leukemia; a case report of a woman with peritonsillar swelling and bleeding; and Perspectives on the power of physicians in dangerous times, on community health centers, on AI-driven clinical documentation, and on driving Jackson.
Featuring articles on high-risk smoldering multiple myeloma, M. tuberculosis infection, type 2 diabetes, uncontrolled hypertension, and lymphoma; a review article on the chemistry of food; a case report of a man with weight loss, weakness, and anorexia; and Perspectives on the dismantling of foreign-assistance efforts, on the crushing weight of nonclinical demands in primary care, and on the last dose.
Featuring articles on lipoprotein(a), familial polycythemia, leukocyte adhesion deficiency, COPD, and on policies on reducing alcohol consumption; a review article on addressing alcohol use; a Clinical Problem-Solving on gazing into a crystal ball; and Perspectives on death and taxes, on cancer metastases, and on a good innings.
Featuring articles on bronchiectasis, influenza, clonal hematopoiesis of indeterminate potential, and metachromatic leukodystrophy; a review article on biology of the Fc neonatal receptor; a case report of a woman with sore throat and rash; and Perspectives on HIV preexposure prophylaxis, on fossil fuels, and on Medicaid’s mandate for children and adolescents.
Featuring articles on obinutuzumab in active lupus nephritis, tecovirimat for mpox, treatments for paroxysmal atrial fibrillation, and gene therapy for hemophilia B; a review article on enteral nutrition in hospitalized adults; a case report of a woman with cough and weight loss; and Perspectives on withdrawal of the United States from the WHO, on what’s next for nicotine, on the value zeitgeist, and on doctors in revolution and war.
Featuring articles on cancer-associated venous thromboembolism, endovascular treatment for stroke, dapagliflozin in patients undergoing TAVI, screening for prostate cancer, and extrachromosomal DNA; a review article on otitis media in young children; a case report of a woman with flank pain, fever, and hypoxemia; and Perspectives on some efforts toward equity and on breaking the sacred promise.
Featuring articles on HIV prevention, left atrial appendage closure after ablation for atrial fibrillation, timing of thrombolysis for stroke, congenital diarrhea and enteropathy, and the association between wealth and mortality in the United States and Europe; a review article on malaria; a Clinical Problem-Solving describing a “hot” cardiomyopathy; and Perspectives on physician shadowing, application overload, medical school grading, and impersonal personal statements.
Featuring articles on intensive blood-pressure control in patients with diabetes, IgG4-related disease, severe chronic rhinosinusitis, advanced breast cancer, and vaccinating against C. difficile infection; a review article on chronic cough in adults; a case report of a man with hepatocellular carcinoma; an editorial on order out of chaos; and Perspectives on health care bridges, on partnerships between pharmaceutical and telehealth companies, and on the definition of failure.
Featuring articles on breast cancer, bloodstream infection, subarachnoid hemorrhage, scrub typhus, and birth-related mortality; a review article on the evaluation and treatment of infertility; a case report of a woman with altered mental status and acidemia; and Perspectives on advancing transgender health amid policy threats, on evidence-based work design, and on what an oncologist had wished she had done for a grieving father.
Featuring articles on bacterial vaginosis, diabetes prevention, Danon disease, chronic spontaneous urticaria, and VITT-like monoclonal gammopathy of thrombotic significance; a review article on micronutrients; a Clinical Problem-Solving on unveiling the unforeseen; and Perspectives on bankruptcy and genetic information, on drug development for rare diseases, on facing political attacks on medical education, and on sustaining equity efforts in the face of regression.
Featuring articles on ventricular tachycardia, chronic lymphocytic leukemia, chronic kidney disease, kidney allografts, and a low-dose yellow fever vaccine; a review article on tubal ectopic pregnancy; a case report of a man with abdominal pain; and Perspectives on reducing the financial toxicity of rapidly approved drugs, on resilience, and on the death of an unlikable man.
Featuring articles on therapies in acute myocardial infarction and in neuroendocrine tumors, mpox in Africa, and T-cell lymphoma after CAR T-cell therapy; a review article on food and nutrition insecurity; a case report of a woman with headache and dysesthesia; and Perspectives on Marburg virus disease in Rwanda, on the rise of private equity in health care, and on medical aid in dying.
Featuring articles on IgA nephropathy, a treatment in children with obesity, NRG1 fusion–positive cancer, a case of a T-cell lymphoma, and the discovery of GLP-1–based drugs; a review article on hemophagocytic lymphohistiocytosis, a Clinical Problem-Solving on traveling companions; and Perspectives on cell and gene therapies, on gender-affirming care, and on the man who lives in the cardboard box.
Featuring articles on heart failure and obesity, oral anticoagulation during TAVI, hemophilia A, hereditary angioedema, and tuberculosis; a review article on sport-related concussion; a case report of a man with syncope, ankle swelling, and abnormal chest imaging; and Perspectives on e-cigarettes at the Supreme Court, on providing interstate telehealth abortion services to patients in restrictive states, on listening to TikTok, and on what is the relative value of a baby.
Featuring articles on esophageal cancer, out-of-hospital cardiac arrest, and atrial fibrillation; a review article on the physiology of hunger; a case report of a man with exertional dyspnea and chest pain; a Medicine and Society on evaluating the inclusion of sex in clinical algorithms; and Perspectives on Ebola, on U.S. generic drug shortages, on gender-affirming surgical care in carceral settings, and on the pediatrician’s lament.
Featuring articles on asymptomatic severe aortic stenosis, kidney disease, fracture prevention in women, and residual breast cancer, the future of the U.S. physician workforce, mutant KRAS signaling, and manufactured chemicals and children’s health; a review article on the identification and treatment of alcohol use disorder; a case report of a man with loss of consciousness and a fall; and Perspectives on striking a balance, on changing Medicare payment to strengthen primary care, and on Schrödinger’s cancer.
Featuring articles on transcatheter tricuspid-valve replacement, persistent chylomicronemia, multiple myeloma, myelofibrosis, and peripherally inserted central catheter materials; a review article on heart failure with preserved ejection fraction; a case report of a woman with shortness of breath and leg edema; and Perspectives on the plight of “dual noneligible” people in the United States, Texas Executive Order GA-46, improving outcomes after fragility fractures, and on seeing the harm.
Featuring articles on advanced melanoma, atrial fibrillation, ATTR amyloidosis, and bladder cancer; a review article on cervical cancer; a Clinical Problem-Solving describing when blurry vision clouds the bigger picture; Medicine and Society’s on transitional justice and on rethinking access to HIV medicines; and Perspectives on hepatitis C therapies, on when diversity goals meet multiregional trials, and on miles to go and nowhere to sleep.
Featuring articles on cancer cachexia, MDR tuberculosis, Ebola virus disease, and severe asthma; a review article on the nonsurgical management of chronic venous insufficiency; a case report of a woman with end-stage liver disease and headache; and Perspectives on providing effective medical care to autistic people, on independent physician associations, on face-to-face learning, and on those who are well known to us.
Featuring articles on PCI before transcatheter aortic-valve implantation, treatments in patients with type 2 diabetes, in leprosy, in refractory adult ALL, and in ATTR cardiomyopathy; a review article on drug reaction with eosinophilia and systemic symptoms; a case report of a boy with recurrent fever; and Perspectives on an autopsy of a drug withdrawal, on clearing dense drug-patent thickets, on how a survey change sheds light on iatrogenic opioid use disorder and on being tethered.
Featuring articles on treatments for atrial fibrillation and stable coronary disease, for chronic hepatitis B, and for metastatic breast cancer; the 30-year cardiovascular disease risk in healthy women; and prenatal screening and detection of maternal cancer; a review article on sepsis and septic shock; a case report of a woman with headache, fever, and respiratory failure; and Perspectives on Medicare’s bundled-payment programs, on handcuffs and unexpected deaths, on the Marburg outbreak in Rwanda, and on the care that saved one parent.
Featuring articles on pembrolizumab perioperative therapy in breast cancer, reduced dose schedules or fractional doses of pneumococcal conjugate vaccine, and nivolumab plus ipilimumab in colorectal cancer; a review article on degenerative rotator-cuff disorders; a case report of a man with seizures and agitation; a Clinical Implications of Basic Research on boning up on boning up; and Perspectives on the Duffy null phenotype; on sickle cell trait, inequity, and the need for change, on “target trial emulation” for observational studies, and on a good day.
Featuring articles on a nationwide couple-based genetic screening; adjunctive embolization for subdural hematoma; a late-liver-stage attenuated malaria vaccine; and climate change, floods, and human health; a review article on Candida auris infections; a case report of a girl with abdominal pain; and Perspectives on Medicare’s first round of drug-price negotiation; on invisible deaths; on minding the sentinel; and on Saint Didacus, fetal death, and dual loyalty.
Featuring articles on perioperative durvalumab in bladder cancer, transcatheter valve repair for mitral regurgitation, chemoradiotherapy in gastric cancer, and lessons from England’s National Health Service; a review article on lung transplantation; a case report of a newborn with hypoxemia and a lung opacity; and Perspectives on our latest brief case studies on efforts toward equity and on forensic nurse examiners.
Featuring articles on an invasive treatment strategy in older patients with myocardial infarction, a randomized trial of very early medication abortion, therapies in stage III melanoma, and on long Covid defined; a review article on uterine fibroids; a Clinical Problem-Solving on two sides to the story; and Perspectives on the U.S. Latino HIV crisis, on reframing cerebral palsy as a lifelong disability, and on an older patient and his physician finding an immediate, resonant connection in a haunting song recalled from long ago and far away.
Featuring articles on semaglutide in persons with obesity and knee osteoarthritis, the addition of PI3K inhibition in breast cancer, treatments in older patients with myeloma, and total hip replacement for hip osteoarthritis; a review article on lead poisoning; a case report of a man with dyspnea after old myocardial infarction; and Perspectives on large language models and the medical record, on measuring AI against the health care we have, on the failing U.S. health system, and on the contemporary rise of pronatalism.
Featuring articles on treatments in heart failure, advanced non–small-cell lung cancer, and Dupuytren’s contracture; a neurodevelopmental disorder caused by deletion in a long noncoding RNA; a review article on burnout and depression among physicians; a case report of a woman with confusion, aphasia, and a brain mass; a Medicine and Society article on how the idea of social contagion shaped trans medicine; and Perspectives on navigating clinicians’ conscience-based refusals, on opportunity costs of Medicare Advantage rebates, on celebrating public health, and on taking our own medicine.
Featuring articles on nivolumab in advanced Hodgkin’s lymphoma, kidney transplantation from donors with HIV, a modular communicative leadless pacing–defibrillator system, stereotactic body radiotherapy in prostate cancer, and on how DNA sensing drives inflammation; a review article on cryoglobulinemia; a case report of a woman with dyspnea, dysphagia, and dysarthria; and a Special Report and Perspectives on the U.S. elections and health policy.
Featuring articles on beta-blocker use after myocardial infarction and treatments for cerebral adrenoleukodystrophy and for small-cell lung cancer; a review article on hairy-cell leukemia; a case report of a man with fever, myalgia, jaundice, and respiratory failure; and Perspectives on Mpox, on addressing health care cost growth, and on confirmatory trials of accelerated approval drugs.
Featuring articles on lenacapavir for HIV prevention in cisgender women, tirzepatide for treatment of obstructive sleep apnea, lymphadenectomy for muscle-invasive bladder cancer, secondary T-cell lymphoma after CAR T-cell therapy, and immunity and early colorectal carcinogenesis; a review article on prolonged grief disorder; a Clinical Problem-Solving on avoiding rash decisions; and Perspectives on health care reform and the 2024 U.S. elections, on financial toxicity for patients from the use of AI, on the Supreme Court’s shadowy treatment of public health, and on caring for our communities.
Featuring articles on systematic vs. targeted biopsy for prostate cancer screening, ziresovir in hospitalized infants with RSV, gene therapy for factor IX deficiency, and a phase 2 trial of tulisokibart for ulcerative colitis; a review article on neuroleptic malignant syndrome; a case report of a woman with kidney lesions and lytic bone disease; and Perspectives on Dobbs revisited, on the role of physicians on ethics committees after Dobbs, on accessible weight scales and exam tables, and on ensuring a safe and sufficient global blood supply.
Featuring articles on long-term oxygen therapy in severe hypoxemia, reducing opioid overdose deaths, blocking CSF1R in chronic GVHD, and pomalidomide in hereditary hemorrhagic telangiectasia; a review article on central nervous system vasculitis; a case report of a man with confusion and kidney failure; a Medicine and Society on house staff unionization revisited; and Perspectives on ethical challenges in pragmatic and cluster RCTs, on the sense and sensibility of sensitivity analyses, and on there being no one in charge.
Featuring articles on treatments in newly diagnosed chronic myeloid leukemia and RNA therapeutics in mixed hyperlipidemia; a review article on clinical approaches to firearm injury prevention; a case report of a woman with edema, arthritis, and proteinuria; and Perspectives on keeping SNAP in line with global evidence, on ingesting risk, on centering the peripheral brain, and on how health care burdens patients.
Featuring articles on doxorubicin plus trabectedin in leiomyosarcoma, a monoclonal antibody for migraine prevention, adjunctive argatroban or eptifibatide for ischemic stroke, and a new orthonairovirus associated with febrile illness; a review article on pancreatic cysts; a case report of a man with pain and dyspnea; a Medicine and Society on building a community of medical learning; and Perspectives on supreme power, on shared savings for nursing homes, on moral injury and the global health workforce crisis, and on asking patients if they feel safe at home.
Featuring articles on amino acid infusion and kidney protection, azithromycin to reduce childhood mortality in Niger, belzutifan in renal-cell carcinoma, and a transfusion strategy in traumatic brain injury; a review article on sexual dysfunction in women; a case report of a woman with aphasia, anemia, and a breast mass; and Perspectives on a series of brief cases on efforts toward equity and on controlling global antimicrobial resistance.
Featuring articles on osimertinib in stage III EGFR-mutated lung cancer, cognitive motor dissociation in disorders of consciousness, rapid deployment of a brain–computer interface in ALS, and the longevity of a brain–computer interface for ALS; a review article on the genetics of chronic kidney disease; a case report of a boy with autism and decreased vision; and Perspectives on medical expertise, on collecting data on sexual orientation and gender identity, and on the pursuit of polka dots.
Featuring articles on crinecerfont in pediatric and adult congenital adrenal hyperplasia, the postacute sequelae of SARS-CoV-2 infection, and nipocalimab in early-onset severe hemolytic disease of the fetus and newborn; a review article on frailty in older adults; a case report of a woman with postpartum anxiety and intrusive thoughts; and Perspectives on refusing to learn the lessons of Covid-19; on preparing for the next pandemic; on collective trauma and commemoration; and on an unknown family history.
Featuring articles on belantamab mafodotin for multiple myeloma, autoantibodies targeting nephrin in podocytopathies, neutralizing anti–interleukin-10 autoantibodies in IBD; a review article on Parkinson’s disease; a Clinical Problem-Solving on going down the rabbit hole; a Medicine and Society article on race-based screening under the ethics microscope; and a Perspective on a legacy of cruelty to sexual and gender minority groups.
Featuring articles on treatments for metabolic dysfunction–associated steatohepatitis, blinatumomab in adults with ALL, and sotorasib for KRAS G12C–driven vascular malformations; a review article on HIV-associated tuberculosis; a case report of a woman with rapidly progressive dementia; and Perspectives on the abandonment of people subjected to sexual and intimate partner violence, on multicancer early detection tests, and on coping in the setting of serious illness.
Featuring articles on tenecteplase for ischemic stroke within 4.5 to 24 hours after the stroke, risankizumab vs. ustekinumab for Crohn’s disease, nirmatrelvir–ritonavir as Covid-19 postexposure prophylaxis, and efanesoctocog alfa in children with hemophilia A; a review article on the management of insomnia; a case report of a woman with postpartum fever, abdominal pain, and skin ulcers; and Perspectives on the ethics of relational AI, on anticipating the next pandemic, and on a first patient.
Featuring articles on semaglutide and chronic kidney disease in type 2 diabetes, felzartamab in kidney-transplant rejection, bulevirtide and peginterferon for chronic hepatitis D, and nirsevimab and hospitalization for RSV bronchiolitis; a review article on malnutrition in adults; a case report of an infant with vomiting and hypercalcemia; and Perspectives on Medicare Advantage and consolidation’s new frontier, on orphan drugs and priorities for the future, on funding post-authorization vaccine-safety science, and on standing on her own two feet.
Featuring articles on stress ulcer prophylaxis during invasive mechanical ventilation, new therapies for hereditary angioedema, tissue factor–directed therapy in cervical cancer, and normalization of C1 inhibitor in a patient with hereditary angioedema; a review article on acute abdomen in the modern era; a Clinical Problem-Solving article on aggregating the loose threads; a Medicine and Society on a case for the Medical Civil Rights Act; and Perspectives on academic freedom in America; on water pollution, health, and medicine’s duty to engage; and on to forgive, divine.
Featuring articles on treatments for eosinophilic esophagitis, reteplase versus alteplase for acute ischemic stroke, dupilumab for COPD with type 2 inflammation, and brigatinib in NF2-related schwannomatosis; a review article on amyloidosis; a case report of a man with recurrent fever and liver lesions; and Perspectives on Alzheimer’s disease, biomarkers, and mAbs; on climate litigation for protecting public health; on carbon-footprint analyses in RCTs; and on the phantom of the organ.
Featuring articles on combination therapy for diffuse large B-cell lymphoma, autosomal dominant Alzheimer’s disease, noninvasive ventilation for preoxygenation during emergency intubation, a novel anti-CD38 antibody in immune thrombocytopenia, and a glucose-responsive insulin for type 2 diabetes; a review article on congenital and acquired Chiari syndrome; a case report of a man with arthritis and rash; and Perspectives on ethics and innovative research on brain diseases, on sustaining and scaling up street medicine, and on the maternal crossroad.
Featuring articles on T-cell cancer after CAR T-cell therapy, the early diagnosis and treatment of COPD and asthma, and the implications of race adjustment in lung-function equations; a review article on diets; a case report of a woman with the worst headache of her life; and Perspectives on efforts toward equity and on feeling guilty.
Featuring articles on neoadjuvant immunotherapy for dMMR colon cancer, TAVR in patients with a small aortic annulus, gene editing and retinal degeneration, and the genetic diagnosis of rare diseases; a review article on disorders of magnesium; a case report of a woman with metastatic breast cancer; and a Perspective on malicious midwives, fruitful vines, and bearded women.
Featuring articles on aficamten for obstructive hypertrophic cardiomyopathy; early blood-pressure reduction in acute stroke; interferon-γ in autoimmune polyendocrine syndrome type 1; video laryngoscopy for intubation in neonates; hunger, thirst, and Buridan’s ass; and global health law for a safer and fairer world; a review article on medical AI and human values; a case report of a man with a pustular rash; and Perspectives on an approach toward a tobacco-free generation, on fair allocation of GLP-1 and dual GLP-1–GIP receptor agonists, on corporate medicine 2.0, and on snapshots.
Featuring articles on andexanet and factor Xa inhibitor–associated hemorrhage, perioperative nivolumab in resectable lung cancer, olezarsen for familial chylomicronemia syndrome, and olezarsen for hypertriglyceridemia; a review article on climate change, extreme heat, and health; a case report of a woman with worsening rash; and Perspective articles on focusing on health care equity, on underestimated challenges for social care initiatives, on integrating public health and health care, and on learning to say goodbye.
Featuring articles on gene editing in severe sickle cell disease and in transfusion-dependent β-thalassemia, thrombectomy for stroke with a large infarct, and recombinant ADAMTS13 in life-threatening immune thrombotic thrombocytopenic purpura; a review article on taste physiology; a case report of a woman with back pain, leg stiffness, and falls; and Perspective articles on the public good on the docket, on reengineering addiction, on welcoming the era of gene editing in medicine, and on all’s fair in love and work.
Featuring articles on a monoclonal antibody to prevent malaria, apolipoprotein A1 and outcomes after myocardial infarction, transcatheter or surgical treatment of aortic-valve stenosis, and recombinant ADAMTS13 in congenital thrombotic thrombocytopenic purpura; a review article on cryptococcal disease in diverse hosts; a Clinical Problem-Solving on the meat of the matter; and a Perspective on Journal voices in the civil rights era.
Featuring articles on empagliflozin after acute myocardial infarction, CD7 CAR T cells with allogeneic stem-cell transplantation, FFR-guided complete revascularization for STEMI, and nutrition for moderate-to-late preterm infants; a review article on age-related hearing loss; a case report of a man with leg weakness; and Perspective articles on hospital consolidation and physician unionization, on the myth of the free market for pharmaceuticals, and on going beyond code status.
Featuring articles on adjuvant pembrolizumab after surgery in renal-cell carcinoma, beta-blockers after MI with preserved ejection fraction, a microaxial flow pump for STEMI and cardiogenic shock, and semaglutide in patients with heart failure and diabetes; a review article on retinoblastoma; a case report of a woman with confusion, aphasia, and abnormal head imaging; and Perspectives on expanding applications of clinical genetic testing, on twenty-five years after Columbine; on advocating for a healthy response to climate change; and on the silver resident.
Featuring articles on alectinib in ALK-positive lung cancer, minimally invasive removal of cerebral hematomas, and CAR T-cell–mediated responses in recurrent glioblastoma; a review article on energy and macronutrients across the life span; a case report of a woman with falls and cognitive decline; a Medicine and Society on money as medicine; and Perspectives on back to the future in Alabama, on the end of B/Yamagata influenza transmission, and on the plight of DEI leaders.
Featuring articles on omitting axillary dissection in breast cancer with sentinel-node metastasis, a trial of lixisenatide in early Parkinson’s disease, nirmatrelvir–ritonavir in outpatients with Covid-19, and hospitalization for chronic kidney disease; a review article on the prevention of cardiovascular disease in type 1 diabetes; a case report of a woman with hyperglycemia refractory to insulin; and a Perspective article on Nazism and the Journal.
Featuring articles on autism and prenatal exposure to antiseizure medication, ribociclib plus endocrine therapy in early breast cancer, gene therapy for giant axonal neuropathy, and anti–interleukin-23 in immunodeficiency; a review article on wearable digital health technologies in clinical care; a case report of a man with a fall; and Perspective articles on physicians, spirituality, and compassionate care; on the risks posed by immediate release of test results to patients; and on what one author did not tell the medical student.
Featuring articles on a blood-based test for colorectal cancer screening, a multitarget stool DNA test for colorectal cancer, iptacopan for paroxysmal nocturnal hemoglobinuria, and preterm birth and other outcomes of maternal RSV vaccination; a review article on cerebral cavernous malformations; a case report of a man with cardiac arrest, cardiogenic shock, and hypoxemia; and Perspective articles on vertical integration and American medicine; on aspirin, preeclampsia, and racism; and on a shift in the night.
Featuring articles on an antibody–drug conjugate in untreated urothelial cancer, omalizumab for multiple food allergies, microplastics and nanoplastics in carotid plaque, and benralizumab or mepolizumab for eosinophilic granulomatosis with polyangiitis; a review article on the health effects of endocrine-disrupting chemicals; a Clinical Problem-Solving on peeling and plummeting; a Medicine and Society on beyond moral injury; and a Perspective article on eugenics in the Journal.
Featuring articles on a trial of seladelpar in primary biliary cholangitis, a trial of elafibranor in primary biliary cholangitis, cognition and memory after Covid-19, and simple versus radical hysterectomy in women with low-risk cervical cancer; a review article on cardiac rehabilitation; a case report of a woman with alternating sixth cranial nerve palsy; and a Perspective article on practicing medicine in the culture wars. We also describe a new cases series on efforts toward equity in health care.
Featuring articles on CD19 CAR T-cell therapy in autoimmune disease, tenecteplase for stroke at 4.5 to 24 hours, biomarker changes in years before Alzheimer’s disease, and a hepcidin mimetic in polycythemia vera; a review article on wearable digital health technologies for epilepsy; a case report of a man with fatigue and night sweats; and Perspective articles on direct-to-consumer platforms for antiobesity medications, on childhood obesity prevention, and on what is a mentor.
Featuring articles on frexalimab in multiple sclerosis, e-cigarettes for smoking cessation, cefepime–taniborbactam for complicated UTI, and the treatment of Wolman’s disease in an infant; review articles on treatment-resistant depression in older adults and on Behçet’s syndrome; a case report of a man with fevers; and Perspective articles on ethical issues in safety-net health systems, on secondary cancers after CAR T-cell therapy, and on being worried about white-cell counts.
Featuring articles on a phase 3 trial of resmetirom in NASH with liver fibrosis, an interleukin-23–receptor antagonist for plaque psoriasis, the neurovascular complications of F. solani meningitis, and on ocular gene therapy; a review article on coccidioidomycosis and histoplasmosis; a case report of a man with fever and headache after international travel; Medicine and Society articles on a physician attack on the FDA and on being well while doing well; and Perspective articles on the risks of normalizing parental vaccine hesitancy, on advanced HIV as a neglected disease, on the challenge of common chronic diseases, and on “the saddest waste”.
Featuring articles on an attenuated tetravalent dengue vaccine, skin antisepsis before fracture surgery, N-acetyl-l-leucine in Niemann–Pick Disease type C, in vivo CRISPR-Cas9 treatment for hereditary angioedema, and on seeing medicine more as a job than a calling; a review article on cardiac implantable electronic devices; a Clinical Problem-Solving on flipping the switch; and a Perspective article on explaining health inequities.
Featuring articles on daratumumab in myeloma therapy, the early treatment of patent ductus arteriosus with ibuprofen, measurable residual disease in chronic lymphocytic leukemia, hospital prices for physician-administered drugs, and on Asian Americans and racial justice in medicine; a review article on wearable technologies in cardiovascular medicine; a case report of an infant with inconsolable crying and weakness; and Perspective articles on minding the gap, on transforming population health, and on the heartbeat.
Featuring articles on ferric carboxymaltose for heart failure with iron deficiency, antibiotic prophylaxis in infants with vesicoureteral reflux, the FGF21 analogue pegozafermin in NASH, and mezigdomide in relapsed and refractory multiple myeloma; a review article on asthma in adults; a case report of a man with a rash; and Perspective articles on a doctrine in name only, on the accelerated approval program for cancer drugs, and on a shared mission.
Featuring articles on the GLP-1 receptor agonist orforglipron for obesity, PCI in older patients with myocardial infarction, DNA editing in T-cell acute lymphoblastic leukemia, and atezolizumab in alveolar soft part sarcoma; a review article on Wilson’s disease; a Clinical Problem-Solving on how it’s all in the timing; and Perspective articles on NIH policy changes regarding international research collaborations, on alleviating medical debt in the United States, and on mass masking without mandates.
Featuring articles on concizumab in hemophilia A or B with inhibitors, the timing of primary surgery for cleft palate, improved mass screening for nasopharyngeal carcinoma, gene editing for sickle cell disease, and on artificial sweeteners; a review article on informative artifacts in AI-assisted health care; a case report of a woman with celiac disease and upper gastrointestinal bleeding; and Perspective articles on Project NextGen, on gerineuropalliative care for patients with dementia, and on sexual and gender minority refugees.
Featuring articles on preventing cardiovascular disease in HIV infection, the effect of hemodiafiltration or hemodialysis on mortality in kidney failure, a new KRAS G12C inhibitor in solid tumors, and on partial artemisinin resistance in malaria parasites; a review article on protein-losing enteropathy; a case report of a girl with abdominal pain and an ovarian mass; and Perspective articles on the Supreme Court and diversity in medicine, on outbreaks in U.S. migrant detention centers, on turning CMS into a health technology assessment organization, and on the clinic that cried safe.
Featuring articles on vorasidenib for IDH-mutant low-grade glioma; a trial of dietary intervention for cognitive decline; omitting radiotherapy after breast-conserving surgery in luminal A breast cancer; gene therapy for the Crigler–Najjar syndrome; and on abortion counseling, liability, and the First Amendment; a review article on community-acquired pneumonia; a case report of a man with fever and foot pain; and Perspective articles on prioritizing mental health in the HIV/ AIDS response in Africa, on reducing health care’s climate impact, and on free and charitable clinics.
Featuring articles on neoadjuvant therapy for lung cancer, a phase 2 trial of retatrutide for obesity, systemic inflammation and normocytic anemia in DOCK11 deficiency, and on the social determinants of health; a review article on thrombocytopenia in pregnant women; a case report of a man with a pulmonary nodule; and Perspective articles on over-the-counter access to HIV preexposure prophylaxis, on preparing physicians for the clinical algorithm era, and on reading Kafka in the hospital cafeteria.
Featuring articles on a novel sodium channel blocker to treat acute pain, the effects of adult thymectomy, video vs. direct laryngoscopy for tracheal intubation, and on antidepressant maintenance in bipolar I depression; a review article on the neurologic consequences of preterm birth; a Clinical Problem-Solving on a race to the finish; and Perspective articles on AI and medical education, on expanding access to health care for DACA recipients, and on the freedom cure.
Featuring articles on weekly insulin icodec or daily glargine in type 2 diabetes, an orexin receptor 2 agonist in narcolepsy, neoadjuvant therapy for rectal cancer, and cilta-cel in lenalidomide-refractory multiple myeloma; a review article on artificial intelligence in U.S. health care delivery; a case report of a young man with progressive dyspnea; and Perspective articles on a critical opportunity to improve public health data, on the future of prior-authorization reform, and on curiosity in clinical care.
Featuring articles on dupilumab for COPD with type 2 inflammation, a maternal group B streptococcus vaccine, an RNA interference therapeutic agent for hypertension, and the antibody NI006 for depletion of cardiac amyloid; a review article on obesity in adolescents; a case report of a woman with hypotension and electrocardiographic changes; and Perspective articles on closing the vaccine-coverage gap for adults, on whether nonprofit hospitals deserve their tax exemption, on pursuing gender equity in primary care, and on the path toward a stronger post-pandemic nursing workforce.
Featuring articles on the cardiovascular safety of testosterone therapy, targeting BRAF in papillary craniopharyngioma, prehospital tranexamic acid for severe trauma, survival with CAR T cells in relapsed lymphoma, and osimertinib in EGFR-mutated non–small-cell lung cancer; a review article on cutaneous electroanalgesia for pain relief; a case report of a man with eyelid swelling; and Perspective articles on Medicare’s plan for drug-price negotiation, on the National Health Service in the United Kingdom, and on hospital problems.
Featuring articles on the early detection and treatment of postpartum hemorrhage, a randomized trial of bulevirtide in chronic hepatitis D, pirtobrutinib in chronic lymphocytic leukemia, and mild hypercapnia after out-of-hospital cardiac arrest; a review article on hepatitis D virus infection; a Clinical Problem-Solving describing a bumpy road to diagnosis; and Perspective articles on PEPFAR at 20, on strategic masking, and on armed-assailant preparedness drills in schools.
Featuring articles on anticoagulation for stroke and atrial fibrillation, familial clonal hematopoiesis and long telomeres, JYNNEOS vaccine effectiveness against mpox, and mirikizumab for ulcerative colitis; a review article on artificial intelligence in molecular medicine; a case report of a man with a solitary fibrous tumor and hypoglycemia; and Perspective articles on sharing pathogen genomic sequence data; on hydrofluorocarbons, climate, and health; and on patient-assistance programs, kickbacks, and the courts.
Featuring articles on ketamine versus ECT in treatment-resistant depression; the Eat, Sleep, Console method for neonatal opioid withdrawal; prophylaxis against graft-versus-host disease; dolutegravir as second-line HIV infection treatment; and a dual-chamber leadless pacemaker; a review article on lateral epicondylitis; a case report of a man with left foot drop; and Perspective articles on the origins of Covid-19, on equity and obesity treatment, and on the ellipsis.
Featuring articles on craniectomy vs. craniotomy for acute subdural hematoma, glucocorticoids for chronic subdural hematoma, a cause of disabling pansclerotic morphea, and antagonistic leptin variants and the treatment of obesity; a review article on squamous-cell carcinoma; a case report of a woman with dyspnea and tachypnea; and Perspective articles on xylazine, on the Jackson water crisis, and on testing for fentanyl.
Featuring articles on outcomes with donor hearts after circulatory death, treatment of gestational diabetes in early pregnancy, and anti-PD1 therapy plus chemotherapy in endometrial cancer; a review article on posterior reversible encephalopathy syndrome; a case report of a woman with fatigue and eosinophilia; and Perspective articles on moving toward comprehensive care for long Covid, on workplace accommodations for long Covid, and on over-the-counter hearing aids.
Featuring articles on tirofiban for stroke, a five-year follow-up after transcatheter repair of secondary mitral regurgitation, diagnostic imaging for pediatric forearm fractures, and AKT pathway inhibition in HR-positive breast cancer; a review article on adipose tissue and insulin sensitivity; a Clinical Problem-Solving describing a wrong turn; and Perspective articles on ensuring a reliable platelet supply, on supporting robust teamwork, and on an invitation to lunch.
Featuring articles on hydrocortisone in severe community-acquired pneumonia, a meningococcal vaccine in Mali and Gambia, platelet transfusion before CVC placement in patients with thrombocytopenia, and upadacitinib therapy for Crohn’s disease; a review article on using AI to interpret medical images; a case report of a boy with depression and hypotension; and Perspective articles on U.S. law and discrimination in health care, on enhancing regulations to reduce exposure to PFAS, and on public health’s role in a post-Dobbs world.
Featuring articles on transcatheter repair for tricuspid regurgitation, rifapentine in household contacts of persons with leprosy, peresolimab for rheumatoid arthritis, and emodepside for T. trichiura and hookworm infections; a review article on tricuspid regurgitation; a case report of a man with paresthesia of the arms and legs; and Perspective articles on advancing community living for people with disabilities, on essential steps for abolishing disability injustice, and on the thin pane.
Featuring articles on anti-CD20 antibodies and venetoclax in chronic lymphocytic leukemia, epicutaneous immunotherapy in toddlers with peanut allergy, cabozantinib in advanced renal-cell carcinoma, and racial inequality in the receipt of medications for opioid use disorder; a review article on HPV vaccination; a case report of a man with redness of the right eye; and Perspective articles on addressing serious illness care in Medicare Advantage, on corporate citizenship and institutional responses post-Dobbs, and on ethical conflicts for clinicians under Tennessee abortion law.
Featuring articles on interrupting therapy to attempt pregnancy after breast cancer, trifluridine–tipiracil and bevacizumab in colorectal cancer, imaging- or angiography-guided PCI for complex lesions, and idiopathic CD4 lymphocytopenia; a review article on neonatal seizures; a Clinical Problem-Solving describing a diagnostic sequence; and Perspective articles on combating West Nile virus disease, on falling insulin prices, on next steps in policy reforms to address the overdose crisis, and on the breast biopsy and the Buddhist half-smile.
Featuring articles on a 15-year follow-up of prostate cancer therapies, on deciphering developmental disorders, blinatumomab in infant acute lymphoblastic leukemia, and a BCG vaccination against Covid-19; a review article on advances in AI for infectious-disease surveillance; a case report of a woman with abdominal pain and jerking movements; and Perspective articles on access to biomedical innovation, on helping people stop smoking, and on racial affinity group caucusing in medical education.
Featuring articles on an RSV vaccine in pregnancy, an RSV vaccine in older adults, sotatercept for pulmonary arterial hypertension, the burden of typhoid and paratyphoid fever in India, cerebral oximetry in extremely preterm infants, and on immune checkpoint inhibitors; a case report of a woman with muscle weakness and myalgia; and Perspective articles on wastewater surveillance for infectious disease, on exacerbating health inequity, and on the breast or bottle.
Featuring articles on bempedoic acid in statin-intolerant patients, tranexamic acid to prevent hemorrhage after cesarean delivery, an oral melanocortin receptor agonist in porphyria, the influence of blood-donor sex on recipient mortality, and on air pollution, mortality, race, and social class; a review article on screening for prostate cancer; a case report of a man with mantle-cell lymphoma and hypoxemia; and Perspective articles on the Courts’ disregard for women’s health and safety, on care integration for dually eligible beneficiaries, and on treating chronic pain in sickle cell disease.
Featuring articles on thrombectomy for large ischemic strokes, CAR T cells for relapsed or refractory neuroblastoma, postexposure doxycycline to prevent bacterial STIs, and the genetic risk of low-grade glioma; a review article on primary Budd–Chiari syndrome; a Clinical Problem-Solving on an alternate explanation; and Perspective articles on ensuring public trust in an empowered FDA, on why diverse clinical trial participation matters, and on a quixotic quest for independence.
Featuring articles on azithromycin to prevent sepsis or death during birth, transcatheter arterialization for limb ischemia, gene–environment interactions and the risk of gastric cancer, vedolizumab for the treatment of chronic pouchitis, a general AI chatbot for medicine, and on dark-alley ethics; a review article on artificial intelligence and machine learning in clinical medicine, 2023; a case report of a man with convulsions; and Perspective articles on the end of a declared public health emergency, on medication-associated diethylene glycol mass poisoning, and on digital minimalism.
Featuring articles on augmenting or switching antidepressants in older adults, lebrikizumab for moderate-to-severe atopic dermatitis, the acute health effects of coffee consumption, Covid-19 staff testing and outcomes in nursing homes, and an mRNA influenza vaccine; a review article on right ventricular failure; a case report of a man with shortness of breath and proteinuria; and Perspective articles on the trials and triumphs of health care antitrust law, on unwinding continuous Medicaid enrollment, and on delirium.
Featuring articles on inaxaplin in persons with two APOL1 variants, expectant management or early ibuprofen for patent ductus arteriosus, closed-loop control in children with diabetes, BCMA-specific CAR T cells in refractory myeloma; a review article on translation defects in neurodegenerative diseases; a case report of a woman with refractory hemolytic anemia; and Perspective articles on Medicare Part D coverage of antiobesity medications, on the erosion of judicial deference to the FDA, and on pregnancy and residency.
Featuring articles on a shorter course for tuberculosis treatment, device-based fever prevention after cardiac arrest, an inhibitor of γ-secretase in desmoid tumors, and the climate gap and the color line; a review article on outcomes after critical illness; a case report of a man with Covid-19, respiratory failure, and rashes; and Perspective articles on diversifying the physician workforce, on electronic prior authorization for prescription drugs, and on when cancer cured pain.
Featuring articles on hydrochlorothiazide and the prevention of kidney stones, the treatment of severe scrub typhus, nicotinamide for skin-cancer chemoprevention, neoadjuvant pembrolizumab in advanced melanoma, cancer screening after paid-sick-leave mandates, and health care in U.S. correctional facilities; a Clinical Problem-Solving describing a rocky resurgence; and Perspective articles on investing in national HIV PrEP preparedness, on health care equity for undocumented immigrants, on the injury equity framework, and on aligning quality measures across CMS.
In “Not Otherwise Specified,” Dr. Lisa Rosenbaum, cardiologist and national correspondent for the New England Journal of Medicine, defies our sound-bite culture to go deep with some of medicine’s most innovative thinkers. Her guests’ stories and ideas about health care’s toughest challenges and greatest promise may change the way you think about medicine, health, and society.
Featuring articles on focused ultrasound ablation for Parkinson’s disease, gene therapy for hemophilia A at 2 years, gene therapy for hemophilia B, and a PARP inhibitor in prostate cancer with DNA-repair defects; a review article on acute kidney injury in patients with cirrhosis; a case report of a man with recurrent strokes; and Perspective articles on fraud, abuse, and financial conflicts of interest; on protecting the legitimacy of medical expertise; and on the princess and the he.
Featuring articles on the omission of radiation in localized breast cancer, two trials of respiratory syncytial virus vaccines in older adults, a Covid-19 vaccine in young children, and uncoupling metastasis from tumorigenesis; a review article on transient global amnesia; a case report of a man with interstitial lung disease, fever, and myalgias; and Perspective articles on choosing the right path toward polio eradication, on the journey to RSV vaccines, and on looking after our own.
Featuring articles on sublobar resection in small lung cancers, fluid management for sepsis-induced hypotension, difelikefalin for notalgia paresthetica, pegylated interferon lambda for Covid-19, and public health policy to end mass incarceration; a review article on rheumatoid arthritis; a case report of a man with abnormal results on testing of liver function; and Perspective articles on bivalent Covid-19 vaccines, on preventing market entry of generics and biosimilars, and on when clinicians should say the word “hospice”.
Featuring articles on baxdrostat for treatment-resistant hypertension, VV116 versus nirmatrelvir for Covid-19, hypothermia or machine perfusion in kidney donors, effectiveness of the 4CMenB vaccine in children, implications of the 2022 election for health policy, and animal models and psychedelic research; a review article on innate immunity; a Clinical Problem-Solving on a breathtaking discovery; and Perspective articles on facing the new Covid-19 reality and on equity in global health research.
Featuring articles on extracorporeal CPR for cardiac arrest, efanesoctocog alfa in severe hemophilia A, zanubrutinib in chronic lymphocytic leukemia, and on using rescaled cystatin C to estimate GFR; a review article on antiretroviral therapy and adverse pregnancy outcomes; a case report of a girl with abdominal pain and bloody diarrhea; and Perspective articles on regulating reproductive medicine without Roe, on sources of innovation in gene therapies, and on the promise.
Featuring articles on aspirin or heparin thromboprophylaxis after a fracture, omicron neutralization with a bivalent vaccine boost, futibatinib for intrahepatic cholangiocarcinoma, and psychosocial functioning in transgender youth; a review article on periprosthetic joint infection; a case report of a man with dizziness and altered mental status; and Perspective articles on social isolation and loneliness as medical issues, on Medicare overpayment for outpatient medication, on being better off at home, and on hope after firearm trauma.
“Intention to Treat,” hosted by health care journalist Rachel Gotbaum, draws on the world-class expertise of the New England Journal of Medicine to present breaking news and incisive analysis of critical and timely issues in medicine and health care. Through interviews with NEJM editors, specialized experts, physicians, and affected patients, each episode explores a story-behind-the-story, giving listeners needed context and a deeper understanding of complex research, cutting-edge medical interventions, and urgent health policy debates that affect patients and the clinicians who care for them. Practicing clinicians, biomedical researchers, medical trainees, patients, and anyone with an interest in health will find unique insights in “Intention to Treat.”
Featuring articles on the progression of atrial fibrillation after cryoablation, empagliflozin in chronic kidney disease, repeat expansion in late-onset cerebellar ataxia, and the safety of inpatient health care; a review article on primary ovarian insufficiency; a case report of a man with hypokalemia and paranoia; and Perspective articles on the anchor strategy and on corporate investors in primary care.
Featuring articles on a monoclonal antibody for early Alzheimer’s disease, risk assessment for patients with heart failure, RAS inhibition in pancreatic cancer, inhibition of mutant KRAS in colorectal cancer, and public health and the Inflation Reduction Act; a review article on new approaches to chronic hepatitis B; a Clinical Problem-Solving on a stormy heart; and Perspective articles on the fresh assault on insurance coverage mandates, on evidence over politics, and on death by ableism.
Featuring articles on chlorthalidone in cardiovascular events, vaccines for Zaire Ebola virus disease, haloperidol for delirium in ICU patients, and reporting of emissions to achieve net-zero health care; a review article on alcohol-associated hepatitis; a case report of a man with exertional chest discomfort; and Perspective articles on understanding the key to outbreak control, on hospitals and health equity, and on engineering for grief.
Featuring articles on surgery or endovascular therapy for limb ischemia, dupilumab in patients with eosinophilic esophagitis, an oral regimen for rifampin-resistant tuberculosis, gene therapy for ART-SCID, and recombinant ADAMTS13 in a pregnant woman with thrombotic thrombocytopenic purpura; a review article on oxygen delivery in the treatment of anemia; a case report of a woman with postpartum abdominal pain and fever; and Perspective articles on U.S. health insurance coverage and financing, on cholera in Haiti, again, and on revaluing primary care.
Featuring articles on gene therapy for dystrophic epidermolysis bullosa, glofitamab in refractory diffuse large B-cell lymphoma, talquetamab for multiple myeloma, once-weekly semaglutide in adolescents with obesity, and on click chemistry; a review article on the risks of infection in xenotransplantation; a case report of a woman with fatigue and weight gain; and Perspective articles on a step toward interoperability of health IT, on a Covid-19 milestone attained, and on the Josephine way.
NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations will enlighten and surprise you as we journey through this very exciting field. Produced by NEJM Group.
Featuring articles on therapy with tumor-infiltrating lymphocytes or ipilimumab in melanoma, biopsy method and overdiagnosis in prostate cancer, methylprednisolone for heart surgery in infants, and in utero enzyme-replacement therapy; a review article on hemochromatosis; a case report of a man with fatigue, weight loss, and pulmonary nodules; and Perspective articles on for-profit medical schools, on closing the gap in cancer genomic testing, and on deciding on her dimples.
Featuring articles on RAS inhibition in advanced chronic kidney disease, buprenorphine versus methadone in pregnancy, iron chelation for Parkinson’s disease, training to prevent crashes in teens with ADHD, and on prolonging cellular life after hypoxic death; a review article on infantile and childhood hydrocephalus; a Clinical Problem-Solving on hiding in plain sight; and Perspective articles on the perpetual challenge of infectious diseases, on prescribing opioids for pain, on the White House Conference on Hunger, Nutrition, and Health, and on injustice disorder.
Featuring articles on pemafibrate to reduce cardiovascular risk, on lifting universal masking in schools, defibrillation strategies for refractory ventricular fibrillation, bepirovirsen in chronic hepatitis B infection, and the IARC perspective on oral cancer prevention; a review article on climate change and vectorborne diseases; a case report of a woman with decreased vision and headache; and Perspective articles on privacy and security, on protecting care for all, and on transgender health and science denialism.
Featuring articles on a monoclonal antibody against malaria in Mali, assessing strategies for spontaneous-breathing trials, lipoprotein(a) and cardiovascular disease, and the Covid-19 vaccine in children and adolescents in Qatar; a review article on gout; a case report of a man with progressive dyspnea, neck swelling, and a lung mass; and Perspective articles on telemedicine, on monkeypox, and on COP27 and urgent action needed for Africa and the world.
Featuring articles on liquefied petroleum gas or biomass for cooking and effects on birth weight, early mobilization during ventilation in the ICU, oxygen-saturation targets for mechanical ventilation, protection against omicron in California prisons, and on cognitive deficits in long Covid-19; a review article on monkeypox; a case report of a woman with Covid-19 and delusions; and Perspective articles on circulating poliovirus in New York, on antiretrovirals in incarcerated populations, and on diagnostic distress.
Featuring articles on the effect of psilocybin on treatment-resistant depression, brentuximab vedotin in pediatric Hodgkin’s lymphoma, early infusion of amino acids and neurodisability at 2 years, and the mRNA-1273 vaccine in children 6 months to 5 years of age; a review article on noninvasive respiratory support in acute respiratory failure; a Clinical Problem-Solving on a shear decline; and Perspective articles on whether it is burnout or depression, on pharmaceutical marketing revisited, and on the worst thing.
Featuring articles on colonoscopy screening and colorectal cancer, neoadjuvant cemiplimab for locally advanced skin cancer, racial and ethnic-group differences in bystander CPR, DHA supplementation and IQ after preterm birth, and on abortion restrictions and mental health inequity; a review article on spontaneous intracerebral hemorrhage; a case report of a girl with redness of the eyes; and Perspective articles on medical malpractice law, on abortion access as a racial justice issue, on the national coverage determination for aducanumab, and on what Covid has taught the world about ethics.
Featuring articles on two randomized trials of ruxolitinib cream for vitiligo, blood-pressure and oxygen targets in comatose patients after cardiac arrest, intermittently scanned glucose monitoring, and on recognition for integrin research; a review article on myocarditis; a case report of a man with postoperative cardiogenic shock and diffuse rash; and Perspective articles on impending relief for Medicare beneficiaries, on on- and off-ramps of oncology accelerated approval, and on an emergency room trajectory.
Featuring articles on PCI for ischemic left ventricular dysfunction, endovascular treatment of basilar-artery occlusion, five-year outcomes of the Danish Cardiovascular Screening trial, and a report on twin boys with excessive caloric intake but low body weight; a review article on the treatment and prevention of heat-related illness; a case report of a man with heartburn, nausea, and inability to eat; and Perspective articles on access to treatment for opioid use disorder, on repealing state drug-paraphernalia laws, and on new federal incentives for diversity in trials.
Featuring articles on cerebral embolic protection during TAVR, intravenous immune globulin in dermatomyositis, omicron-containing mRNA vaccine booster immunogenicity, an extravascular implantable cardioverter–defibrillator, the Lasker Award for discovery of circulating cell-free DNA, and on going from the eyeball test to the algorithm; a review article on drowning prevention and initial treatment; a Clinical Problem-Solving on thinking outside the heart; and Perspective articles on public carry versus public health, on intimate-partner violence after Dobbs and Bruen, and on the macro-harm of micro-geography.
Featuring articles on a bionic pancreas in type 1 diabetes, bronchodilators in symptomatic tobacco-exposed persons, acetazolamide in acute decompensated heart failure, and a new target for CAR T cells in myeloma; a review article on gastroesophageal reflux disease; a case report of a newborn girl with hypoglycemia; and Perspective articles on the war-zone mentality, on intradermal vaccination for monkeypox, on product hopping in the drug industry, and on a hidden crisis.
Featuring articles on glycemic outcomes of glycemia reduction, microvascular outcomes of glycemia reduction, dapagliflozin in heart failure with preserved ejection fraction, and an antisense oligonucleotide for SOD1 ALS; a review article on Burkitt’s lymphoma; a case report of a man with chronic diarrhea and autoimmune enteropathy; and Perspective articles on the law of licensure and quality regulation, on pushing back with pills, and on the seeds of ignorance.
Featuring articles on a polypill for secondary cardiovascular prevention, anticoagulation in atrial fibrillation with rheumatic heart disease, aggressive or moderate hydration in acute pancreatitis, and enteral glutamine for burn injuries; a review article on Covid-19 vaccines; a case report of a man with headache and progressive neurologic dysfunction; and Perspective articles on protecting pregnant people from climate change, on professional civil disobedience, on closing the public health ethics gap, and on finding a new mantra.
Featuring articles on an open-source automated insulin delivery system in type 1 diabetes, closed-loop therapy in type 1 diabetes, litifilimab for systemic lupus erythematosus, routine functional testing after PCI, metagenomic sequencing and infectious disease, and race correction and the x-ray machine; a review article on personality disorders; a case report of a man with confusion, headache, and fever; and Perspective articles on emergency department ethics in a post-Roe era, on EMTALA for pregnancy-related emergencies, and on science, competing values, and trade-offs.
Featuring articles on FFR versus intravascular ultrasonography to guide PCI, nirmatrelvir for Covid-19 during the omicron surge, antiretroviral HIV treatment in pregnancy, regimens for drug-resistant tuberculosis, and on building Black wealth; a review article on chronic urticaria; a Clinical Problem-Solving on telescoping the diagnostic process; and Perspective articles on what Dobbs means for patients with breast cancer, on the escalating cybersecurity threat to health care, on “fertility fraud” legislation, on updated health warnings for alcohol, and on losing contact.
Featuring articles on the clinical features of monkeypox in humans, the treatment of diabetic macular edema, ublituximab in relapsing multiple sclerosis, olokizumab for rheumatoid arthritis, and on when silence disrupts; a review article on lesions of the ovary and fallopian tube; a case report of a woman with cystic lung disease; and Perspective articles on the physician–patient relationship, on hospital care for substance use disorder, and on improving the use of FDA advisory committees.
Featuring articles on glycemic criteria for the diagnosis of gestational diabetes, a randomized trial of metformin, ivermectin, and fluvoxamine for Covid-19, and children with acute hepatitis of unknown cause; a review article on neuromyelitis optica spectrum disorder; a case report of a woman with headache and blurred vision; and Perspective articles on confronting health worker burnout, on tecovirimat and the treatment of monkeypox, on framing traumatic injury as a chronic condition, and on professionals as targets in the culture wars.
Featuring articles on redirecting T cells against myeloma cells, the removal of small kidney stones and relapse, the treatment of severe alpha1-antitrypsin deficiency, and BNT162b2 protection against omicron in children; a review article on bronchiectasis; a case report of a man with perianal and penile ulcers, pain, and rash; and Perspective articles on race and ethnicity in Covid risk assessments, on understanding Covid vaccine efficacy over time, on noncompete agreements, on bringing sickle-cell treatments to sub-Saharan Africa, and on a critical shortage of iodinated contrast material.
Featuring articles on a monoclonal antibody to prevent malaria infection, monoclonal antibody therapy in Parkinson’s disease, and dulaglutide in youths with type 2 diabetes; a review article on spina bifida; a Clinical Problem-Solving on diagnostic aspirations; and Perspective articles on building a national public health system in the U.S., on a preview of the dangerous future of abortion bans, on the end of Roe v. Wade, and on code words.
Featuring articles on supplemental vitamin D and incident fractures, brentuximab vedotin in advanced Hodgkin’s lymphoma, litifilimab for cutaneous lupus erythematosus, genetic protection against liver disease, and on lawmakers v. the scientific realities of human reproduction; a review article on tobacco addiction; a case report of a man with hypoglycemia; and Perspective articles on the history of health law in the United States, on primary care and financial risk, and on achieving the Triple Aim for sexual and gender minorities.
Featuring articles on tirzepatide for weight loss in adults with obesity, pembrolizumab in triple-negative breast cancer, Covid-19 vaccination in children 5 to 11 years of age, and gene therapy for hemophilia B; a review article on obesity in pregnancy; a case report of a woman with cavitary lung lesions; and Perspective articles on communicating statistics on climate change, on Medical Device User Fee reauthorization, and on grieving in a pandemic.
Featuring articles on maternal vaccination and Covid-19 among infants, adagrasib in KRASG12C-mutated lung cancer, continuous maintenance therapy in myeloma, and erythropoietin for hypoxic–ischemic encephalopathy in newborns; a review article on breakthrough hemolysis after complement inhibition; a case report of a girl with fever and cough; and Perspective articles on moving from regressive toward progressive value-based payment, on expanding accountable care among Medicare beneficiaries, on Russia’s war in Ukraine, and on tackling implicit bias in health care.
Featuring articles on trastuzumab deruxtecan in HER2-low breast cancer, effects of previous infection and vaccination on symptomatic omicron infections, and a report on porcine-to-human cardiac transplantation; review articles on pulmonary embolism and on the vaccine-hesitant moment; a Clinical Problem-Solving on the young and the breathless; and Perspective articles on physicians spreading misinformation on social media, on dietary supplements and institutionalizing misinformation, and on the portal.
Featuring articles on restricted intravenous fluid in septic shock, an oncolytic virus for pediatric pontine glioma, ibrutinib for untreated mantle-cell lymphoma, and on the potency of a KRAS silent variant; a review article on mantle-cell lymphoma; a case report of a man with vision changes; and Perspective articles on nineteen days in America, on a comprehensive Covid-19 response, on the solution shop and the production line, and on being without question.
Featuring articles on PD-1 blockade in locally advanced rectal cancer, a vaccine against respiratory syncytial virus, a vitamin C infusion in adults with sepsis, and reducing administrative harm in medicine; a review article on Philadelphia chromosome–positive acute lymphoblastic leukemia; a case report of a woman with jaundice and chronic diarrhea; and Perspective articles on racial disparity in breast-cancer mortality, on enrollee premiums in Medicaid, on a data infrastructure for clinical trial diversity, on medicalizing the Constitution, and on unexpected closure.
Featuring articles on circulating tumor DNA and adjuvant therapy in colon cancer, the prevention of anal cancer, Chapare hemorrhagic fever in Bolivia, immune tolerance after sequential stem-cell and kidney transplantation, and potentiating the T cell; a review article on climate change, fossil-fuel pollution, and children’s health; a case report of a woman with recurrent fractures; and Perspective articles on research to move policy, on climate change in the Supreme Court, and on medical readers and literary plague.
Featuring articles on chronic traumatic encephalopathy in military personnel, a PDE4 inhibitor for idiopathic pulmonary fibrosis, a monoclonal-antibody combination to prevent Covid-19, natural and hybrid immunity to SARS-CoV-2, and emerging technologies in health and medicine; a review article on the diagnosis and treatment of frostbite; a case report of a boy with chest pain; and Perspective articles on a radical treatment for insulin pricing, on the tobacco wars’ lessons for the vaccination wars, on physicians as political pawns, and on the high cost of cancer drugs under Medicare Part D.
Featuring articles on an albuterol–budesonide rescue inhaler in asthma, the efficacy of a plant-based SARS-CoV-2 vaccine, the efficacy and safety of a spike protein subunit vaccine, and neoantigen T-cell receptor gene therapy in pancreatic cancer; a review article on the uses of a GFR and albuminuria level in kidney disease; a Clinical Problem-Solving describing the after-dinner dip; and Perspective articles on navigating the loss of abortion services, on HIV prevention and the 340B Drug Pricing Program, and on the care and treatment of Black girls in America.
Featuring articles on neoadjuvant chemoimmunotherapy in resectable non–small-cell lung cancer, tranexamic acid for noncardiac surgery, activation of oncogene expression by demethylating agents, efficacy of the mRNA-1273 vaccine in older children, and structural racism in the academic residency clinic; a review article on the gliflozins in the management of cardiovascular disease; a case report of a man with fevers, night sweats, and a mediastinal mass; and Perspective articles on federal action supporting overdose-prevention centers, on when naloxone isn’t enough, and on e pluribus unum.
Featuring articles on childhood risk factors and adult cardiovascular events, results of two cases of pig-to-human kidney xenotransplantation, vaccine effectiveness against omicron in children and adolescents, the efficacy and safety of a BNT162b2 booster, catching up on REMs, and on NEJM Healer; a review article on brain tumors in children; a case report of a man with persistent cough and pulmonary opacities; and Perspective articles on reforming nursing home care, on progress toward pig-to-human xenotransplantation, and on being only halfway there with sudden infant death syndrome.
Featuring articles on the treatment of mild chronic hypertension during pregnancy, lenacapavir for HIV-1 treatment, booster vaccination against omicron in Qatar, and on reframing the quality question; a review article on preeclampsia; a case report of a man with chylous ascites; and Perspective articles on health care reform under the Biden administration, on supporting innovation in Medicaid policy, and on unmuting.
Featuring articles on baricitinib for alopecia areata, convalescent plasma for early SARS-CoV-2 infection, efficacy of a fourth mRNA vaccine dose in Israel, ivermectin for early Covid-19, a new image for cell sorting, and metric myopia; a review article on nonspecific low back pain; a Clinical Problem-Solving on looking back; and Perspective articles on designing Cures 2.0, on real-world evidence, and on addressing misinformation on social media.
Featuring articles on CT or coronary angiography in stable chest pain, protection against omicron by a fourth vaccine dose, a vaccine for RSV in pregnancy, nasal high-flow therapy during neonatal intubation, and reassessing quality assessment; a review article on understanding vaccine safety; a case report of a man with myalgias, fever, and bradycardia; and Perspective articles on the e-cigarette flavor debate and on breaking down the residency match rate.
Featuring articles on restricted calories and eating times in weight loss, asthma therapy in Black and Latinx adults, ivosidenib in IDH1-mutated acute myeloid leukemia, vaccine boost effects on protection against omicron, and fighting cardiac fibrosis with CAR T cells; a review article on early-onset colorectal cancer; a case report of a woman with transient ischemic attack and mitral valve masses; and Perspective articles on a change in the leading cause of death among U.S. children, on strengthening the Medicaid Reentry Act, and on Covid-19’s devastating effect on tuberculosis care.
Featuring articles on nirmatrelvir plus ritonavir for Covid-19, the treatment of acute Achilles’ tendon rupture, rilzabrutinib in immune thrombocytopenia, mitapivat for pyruvate kinase deficiency, and global health and the moral clarity of Paul Farmer; a review article on cancer-associated hypercalcemia; a case report of a woman with pancytopenia; and Perspective articles on fully realizing SNAP’s health benefits, on the 2022 Child Nutrition Reauthorization, and reflections on caring for the unvaccinated.
Featuring articles on endovascular therapy for large cerebral infarction, population immunity and Covid-19 severity with the omicron variant in South Africa, tebipenem for complicated urinary tract infection, an implanted stimulator in multiple-system atrophy, U.S. medical faculty diversity over four decades, and the origins of calcific aortic stenosis; a review article on the laboratory diagnosis of Creutzfeldt–Jakob disease; a Clinical Problem-Solving describing a burning question; and Perspective articles on ten years of Choosing Wisely to reduce low-value care, on putting health and equity at the center of the climate movement, and on the wild west of checkpoint inhibitor development.
Featuring articles on Covid-19 after vaccination and previous infection, vaccination after recovery from SARS-CoV-2 infection, mini-slings for stress incontinence in women, higher-dose primaquine for P. vivax malaria, and on how medicine is not gender-neutral; a review article on decompression sickness and arterial gas embolism; a case report of a man with marked ventricular wall thickening; and Perspective articles on restrictive state abortion bans, on when patients go to court for unproven treatments, and on epidemiology and the Faroe Islands.
Featuring articles on a single-dose liposomal amphotericin B treatment for cryptococcal meningitis, hydrocortisone to prevent bronchopulmonary dysplasia, darolutamide in metastatic prostate cancer, trastuzumab deruxtecan for HER2-positive breast cancer, addressing vaccine inequity, and targeting gene therapy to muscle; a review article on managing glycemia in children with type 1 diabetes; a case report of a woman with fever, myalgias, diarrhea, and cough; and Perspective articles on digital inclusion as health care, on a new way to contain unaffordable medication costs, and on an NPO.
Featuring articles on gene therapy for hemophilia A, prekallikrein and hereditary angioedema, a trial of a cereblon modulator in lupus, and the immune effects of Covid-19 vaccine boosters; a review article on cryptogenic organizing pneumonia; a case report of a woman with episodes of swelling; and Perspective articles on a malaria vaccine for Africa, on where Americans die, and on the patient resident.
Featuring articles on shorter-course TB treatment in children, thyroidectomy without radioiodine, Covid-19 vaccine effectiveness in North Carolina, ribociclib in hormone receptor–positive breast cancer, the effects of boosters after Ad26.COV2.S vaccination, and on tumors and T cells; a review article on extracorporeal kidney-replacement therapy for acute kidney injury; a case report of a woman with depression, recurrent falls, and inability to care for herself; and Perspective articles on step therapy’s balancing act, on coverage of transvenous pulmonary embolectomy, and on the catfish king.
Featuring articles on a balanced multielectrolyte solution versus saline in critically ill adults, troponin I after cardiac surgery and 30-day mortality, nirsevimab for prevention of RSV in infants, a final analysis of single-dose Ad26.COV2.S, and melioidosis and aromatherapy; a review article on chronic pancreatitis; a Clinical Problem-Solving on craving answers; and Perspective articles on U.S. public health law, on oral health for all, and on holding the baby.
Featuring articles on the effectiveness of the BNT162B2 vaccine in adolescents, the treatment of epileptiform activity after cardiac arrest, mechanisms of resistance to noncovalent BTK inhibitors, Covid-19 vaccination and delta transmission, mortality from congenital Zika syndrome in Brazil, and wound healing and stem cells; a review article on reassessing human adipose tissue; a case report of a man with fatigue, weight loss, and hyperglycemia; and Perspective articles on state restrictions on mifepristone access, on abortion training in medical education, and on stabilizing health care’s share of the GDP.
Featuring articles on LentiGlobin for sickle cell disease, tisagenlecleucel in aggressive B-cell lymphoma, axi-cel for relapsed or refractory large B-cell lymphoma, and EDP-938 to treat respiratory syncytial virus; a review article on electroconvulsive therapy; a case report of a woman with rapidly progressive weakness in the right arm and recurrent falls; and Perspective articles on health care safety during the pandemic and beyond, on inherited patients taking opioids for chronic pain, and on home help.
Featuring articles on molnupiravir for outpatient treatment of Covid-19, cemented or uncemented hemiarthroplasty for hip fracture, efficacy of the NVX-CoV2373 vaccine against Covid-19, PD-1 inhibition in relapsed cervical cancer, pembrolizumab for triple-negative breast cancer, and a pernicious cycle affecting premalignant stem cells; a review article on marginal-zone lymphomas; a case report of a man with bilateral hearing loss and eye redness; and Perspective articles on racial biology and medical misconceptions, on developing new models for health, and on roulette.
Featuring articles on gene therapy for β-thalassemia, mosquito nets and survival to adulthood in Tanzania, lenvatinib plus pembrolizumab for advanced endometrial cancer, and immune checkpoint therapy in esophageal cancer; a review article on fever of unknown origin; a Clinical Problem-Solving on the calm before the storm; and Perspective articles on using economics to inform public health policy, on automatic insurance policies, and on the care that was needed.
Featuring articles on remdesivir for prevention of Covid-19 progression, cardiovascular and cancer risk with tofacitinib, tricuspid repair in mitral-valve surgery, duration of Covid-19 vaccine protection in the U.K., polatuzumab vedotin in diffuse large B-cell lymphoma, and anti-idiotype antibodies in SARS-CoV-2; a review article on medical conditions and high-altitude travel; a case report of a boy with fever, joint pain, and abdominal cramping; and Perspective articles on universal coronavirus vaccines, on transparency and the doctor–patient relationship, and on “Please don’t keep me”.
Featuring articles on a randomized closed-loop trial in very young children with diabetes, microbiome therapy for C. difficile infection, secondary prophylaxis for latent rheumatic heart disease, targeting mutant HER2 in non–small-cell lung cancer, urinary sodium and potassium and cardiovascular risk, and on aesthetic distance and empathy; a review article on rapid diagnostic testing for SARS-CoV-2; a case report of a man with a recurrent left pleural effusion; and Perspective articles on research participation and diversity.
A 38-year-old woman with type 2 diabetes has a telemedicine visit after learning that a person with whom she had close contact at an indoor wedding 3 days earlier has tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The woman reports that she is asymptomatic and received a second vaccination against SARS-CoV-2 approximately 9 months ago but has not received a booster vaccination. She attended the wedding with her husband, who has also received two vaccinations, and her two unvaccinated children, who are 5 and 8 years of age. Her husband had mild nasal congestion and a cough the evening before her appointment. She had previously purchased rapid diagnostic tests that received emergency use authorization from the Food and Drug Administration for home-based SARS-CoV-2 testing and wonders whether using these tests would be appropriate. What would you advise? Full-text recordings of Clinical Practice articles may be found at NEJM.org.
Featuring articles on the efficacy of mRNA vaccines in U.S. veterans, Covid-19 vaccine effectiveness in New York state, FFR-guided PCI as compared with coronary bypass surgery, an acute myeloid leukemia case after gene therapy for sickle cell disease, cannabis legalization and THC levels in injured drivers, oocytes from stem cells, and a new journal in the NEJM Group family; a review article on biologic therapies for severe asthma; a case report of a man with motor neuron disease and odd behaviors during sleep; and Perspective articles on reengineering GME in a pandemic and on expanded lung and colorectal cancer screening.
Featuring articles on eltrombopag in severe aplastic anemia, nivolumab plus LAG-3 blockade in melanoma, the BNT162b2 vaccine against Covid-19 in 5-to-11-year-olds, azithromycin for yaws eradication, and abortion outcomes with unrestricted mifepristone; a review article on snake envenomation; a Clinical Problem-Solving on being confused about confusion; and Perspective articles on the patchwork U.S. public health system, on obstacles to physicians’ emotional health, and on the doctor’s oldest tool.
Featuring articles on chlorthalidone for hypertension in advanced chronic kidney disease, ticagrelor versus clopidogrel in stroke or transient ischemic attack, dolutegravir in children with HIV-1 infection, angiography after out-of-hospital cardiac arrest, and the 2021 Nobel Prize in Chemistry; a review article on the determination of brain death; a case report of a boy with transient weakness, facial droop, and slurred speech; and Perspective articles on whether we should include race or ethnicity at the beginning of clinical case presentations, on calling out aversive racism in academic medicine, on closing the gender pay gap in medicine, and on trust, faith, and Covid.
Featuring articles on the effects of a Covid-19 vaccine booster, spesolimab for generalized pustular psoriasis, decentralized molecular testing for tuberculosis, and consultative medicine; a review article on immune and genome engineering as the future of transplantable tissue; a case report of a woman with respiratory failure and altered mental status; and Perspective articles on clinical care and Amazon, on Covid-19 vaccination in American Indians and Alaska Natives, on tobacco-free nicotine, and on a divisive ruling on devices.
Featuring articles on daprodustat in patients undergoing dialysis and in those not undergoing dialysis, chemotherapy in node-positive breast cancer, a phase 3 trial of the ChAdOx1 nCoV-19 vaccine, vaccine effectiveness among U.S. health care personnel, and a hot and tactile Nobel Prize; a review article on pulmonary arterial hypertension; a case report of a woman with abdominal pain, weight loss, and memory impairment; and Perspective articles on a failure to disseminate transformative science, on E66.01 and our culture of shame, and on Ms. Omega One.
Featuring articles on tapinarof cream for psoriasis, dupilumab in children with asthma, the mRNA-1273 vaccine in adolescents, cardiovascular events with finerenone in kidney disease and type 2 diabetes, waning vaccine protection against SARS-CoV-2, and transgenic epidermis in junctional epidermolysis bullosa; a review article on latent tuberculosis infection; a case report of a man with fevers, fatigue, arthralgias, a mouth ulcer, and a rash; and Perspective articles on Covid-19 and the safety net and on inequitable access to hospital care.
Featuring articles on debulking surgery in relapsed ovarian cancer, myocarditis after Covid-19 mRNA vaccine, edoxaban for atrial fibrillation with TAVR, milvexian for the prevention of venous thromboembolism, REGEN-COV in outpatients with acute SARS-CoV-2 infection, and a font of protein structures; a review article on spontaneous intracranial hypotension; a Clinical Problem-Solving describing a “fluid” diagnosis; and Perspective articles on using policy tools to improve population health, on decarbonizing the U.S. health sector, and on the web we weave.
Featuring articles on spinal or general anesthesia for hip surgery, HIF-2α inhibition in von Hippel–Lindau disease, live birth after genetic testing for aneuploidy, belzutifan in the Pacak–Zhuang syndrome, and on responsible innovation in reproductive medicine; a review article on osteosarcoma; a case report of a man with pain and erythema of the left hand; and Perspective articles on why aducanumab is priced at $56,000 per patient, on Medicare coverage of aducanumab, and on the little things.
Featuring articles on hematopoietic gene therapy for Hurler syndrome, sotrovimab for early Covid-19, convalescent plasma for high-risk Covid-19, gene therapy for hemophilia A, parathyroid hormone resistance, and on hunger and mood; a review article on salt handling and blood pressure; a case report of a woman with pain in the left upper quadrant and hypoxemia; and Perspective articles on regulating drug prices while increasing innovation and on the drug-pricing debate redux.
Featuring articles on alteplase followed by endovascular treatment for stroke, sacubitril–valsartan in acute myocardial infarction, pembrolizumab in advanced cervical cancer, genome sequencing in health care, and screening for cervical cancer; a review article on pollution and the heart; a case report of a man with altered mental status and new onset of seizures; and Perspective articles on the future of SARS-CoV-2 vaccination and on when women and children made the policy agenda.