Out of the Blue: An AJRCCM Podcast: Recent Episodes
American Thoracic Society
The Out of the Blue podcast takes you out of the pages of the American Journal of Respiratory and Critical Care Medicine and into the minds of the most brilliant researchers in the fields of respiratory, critical care, and sleep medicine.
Dr. John Fleetham chats with Dr. Raphael Heinzer about his article, "Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea."
Dr. Michael Lanspa chats with Dr. Kevin Seitz and Dr. Matthew Churpek about their article, "Individualized Treatment Effects of Bougie vs Stylet for Tracheal Intubation in Critical Illness."
Paper discussed in today's episode:
High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial
Article discussed in this episode:
Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome Associated with COVID-19: An Emulated Target Trial Analysis
Article discussed in this episode:
Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities
Articles discussed in this episode:
“A Randomized Controlled Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea"
“Drug Therapy for Obstructive Sleep Apnea: Are We There Yet?”
Article discussed in this episode:
Liberation from Invasive Mechanical Ventilation with Continued Receipt of Vasopressor Infusions
Article discussed in this episode:
Effect of Weight Loss and CPAP on OSA and Metabolic Profile Stratified by Craniofacial Phenotype: A Randomized Clinical Trial
Articles discussed in today's episode:
A Rapid Pharmacogenomic Assay to Detect NAT2 Polymorphisms and Guide Isoniazid Dosing for Tuberculosis Treatment
A Semimechanistic Model of the Bactericidal Activity of High-Dose Isoniazid against Multidrug-Resistant Tuberculosis: Results from a Randomized Clinical Trial
Using Isoniazid More Safely and More Effectively: The Time Is Now [Editorial]
[Note: The episode was updated on February 24, 2022, to fix an audio editing error.]
Article discussed in today's episode:
Multi-night Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea
Article discussed in today's episode:
Alpha-1 Antitrypsin MZ Heterozygosity is an Endotype of Chronic Obstructive Pulmonary Disease
Article discussed in today's episode:
Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids
Article discussed in today's episode:
Effect of Esophageal Pressure-Guided Positive End-Expiratory Pressure on Survival from Acute Respiratory Distress Syndrome: A Risk-Based and Mechanistic Reanalysis of the EPVent-2 Trial
Paper discussed in today's episode:
An Association Between Positive Airway Pressure (PAP) Device Manufacturer and Incident Cancer?: A Secondary Data Analysis
Article discussed in today's episode:
Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications
Article discussed in today's episode:
Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury
Article discussed in today's episode:
Effect of Continuous Positive Airway Pressure on Arrhythmia in Atrial Fibrillation and Sleep Apnea: A Randomized Controlled Trial
Article discussed in today's episode:
Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain
Article discussed in today's episode:
Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe Acute Respiratory Distress Syndrome. A Network Meta-Analysis
Article discussed in today's episode:
Antigen-specific T Cell Activation Distinguishes Between Recent and Remote Tuberculosis Infection
Dr. Escalante's editorial on the paper:
New Diagnostics to Infer Risk in Tuberculosis: Is the Term Latent Tuberculosis Infection Obsolete?
Article discussed in today's episode:
Lung Ultrasound to Monitor Extremely Preterm Infants and Predict BPD: Multicenter Longitudinal Cohort Study
Article discussed in today's episode:
Effect of Lowering Tidal Volume on Mortality in ARDS Varies with Respiratory System Elastance
Article discussed in today's episode:
Quantitative Assessment of Viral Dispersion Associated with Respiratory Support Devices in a Simulated Critical Care Environment
Article discussed in today's episode:
CPAP Restores Declarative Memory Deficit in Obstructive Sleep Apnea
Dr. Michael Lanspa sits down with AJRCCM editor Dr. Sanjay H. Chotirmall to discuss some of the most impactful COVID papers published in the AJRCCM over the past year and what we can expect moving forward.
Podcasts discussed in today's episode:
Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock
Treatment of Drug-Resistant Tuberculosis
ATS Guideline on Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic COPD
ATS Guideline on Home Oxygen Therapy for Adults with Chronic Lung Disease
Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia
Association of Pre-Morbid Blood Pressure with Vasopressor Infusion Duration in Patients with Shock
Relative Hypotension and Adverse Kidney-Related Outcomes Among Critically Ill Patients with Shock
The COVID-19 Pandemic Presents an Opportunity to Reassess the Value of Polysomnography
An Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis
Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A
Article discussed in today's episode: Home Oxygen Therapy for Adults with Chronic Lung Disease. An Official American Thoracic Society Clinical Practice Guideline
Article discussed in today's episode: Cardiopulmonary Resuscitation-Associated Lung Edema (CRALE) - A Translational Study
Article discussed in today's episode: Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline
Article discussed in today's episode: Tissue Doppler Imaging of the Diaphragm in Healthy Subjects and Critically Ill Patients
Link to the article discussed: Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock
Article discussed in today's episode:
Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia
Paper discussed in today's episode:
Relative Hypotension and Adverse Kidney-related Outcomes Among Critically Ill Patients with Shock- A Multicenter Prospective Cohort Study
Articles discussed in today's episode:
The COVID-19 Pandemic Presents an Opportunity to Reassess the Value of Polysomnography
The Baby, the Bathwater, and the Polysomnogram
Article discussed in today's episode: Hyperoxia Injury in the Developing Lung Is Mediated by Mesenchymal Expression of Wnt5A
Article discussed in today's episode: Association of Pre-Morbid Blood Pressure with Vasopressor Infusion Duration in Patients with Shock
The article discussed in today's episode is Open Access and can be found here:
Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in COPD Patients
Link to the article discussed:
Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study
Links to the article and editorial discussed:
Gender Differences in Authorship of Critical Care Literature
Slow Progress toward Gender Equality in Critical Care Medicine
Article discussed in the episode: Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis
Editorial: Coming to “Grp(s)” with Senescence in the Alveolar Epithelium
To learn more about the Novel Coronavirus (COVID-19) and what you can do to keep yourself safe, you can visit the thoracic.org resource page here.
Paper discussed: Outcomes Six-Months After 100% or 70% of Enteral Calorie Requirements During Critical Illness (TARGET): A Randomized Controlled Trial
Article discussed in today's episode: Effect of Weight Loss on Upper Airway Anatomy and the Apnea Hypopnea Index: The Importance of Tongue Fat
The article discussed in today's episode, Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline, is open access and available for free at the ATS Journals website.
Maor Sauler is joined by Drs. Samuel Chung, Matthias Salathe, and Mehmet Kesimer to discuss the article Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors
Dr. Michael Lanspa sits down with Dr. Seppo Rinne to discuss burnout from the perspectives of pulmonary, critical care, and sleep medicine division directors.
Join our podcast hosts Nitin Seam MD and John Fleetham MD as they share their thoughts on some of the most interesting papers related to pulmonary, critical care and sleep medicine published in the AJRCCM in 2019.
Dr. Michael Lanspa sits down with Dr. Edward Palmer to discuss the paper The Association Between Supra-Physiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients: A Multi-Centre Observational Cohort Study.
Dr. Maor Sauler is joined by Drs. Nathaniel Weathington and Brian Modena to discuss the article BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.
Dr. John Fleetham is joined by Drs. Metlay and Waterer to discuss the American Thoracic Society and Infectious Diseases Society of America's official clinical practice guideline on diagnosing and treating adults with CAP.
Dr. John Fleetham is joined by Dr. Babak Mokhlesi to discuss the recently published ATS Guideline on the evaluation and treatment of OHS.
Issue
Dr. Jadwiga Wedzicha, editor-in-chief of the American Journal of Respiratory and Critical Care Medicine, joins Nitin Seam to discuss several important papers from 5/1/19 Blue Journal.
Dr. Trish Kritek is joined by Drs. Jubran and Nava to discuss the paper Long-term Outcome After Prolonged Mechanical Ventilation: A Long-Term Acute-Care Hospital Study
Dr. John Fleetham is joined by Drs. Diego Mazzotti and Henry Yaggi to discuss the paper "Symptom Subtypes of Obstructive Sleep Apnea Predict Incidence of Cardiovascular Outcomes".
Dr. John Fleetham is joined by Luigi Taranto Montemurro, MD, Andrew Wellman, MD, PhD, and Seva Polotsky, MD, PhD to discuss the impact the combination of Atomoxetine and Oxybutynin has on reducing the severity of obstructive sleep apnea.
Dr. Nitin Seam discusses important papers from the special 2/15/19 AJRCCM asthma issue with deputy editor Dr. Fernando D. Martinez and associate editor Dr. Leonardo Fabbri.
David Feller Kopman and Daniel Sterman join Nitin Seam to discuss the recent Clinical Practice Guideline on Management of Malignant Pleural Effusions published in the 10/1/18 American Journal of Respiratory and Critical Care Medicine.
Dr. Trish Kritek sits down with Dr. Jeremy Kahn to discuss what organizational factors may impact the clinical effectiveness of ICU telemedicine programs.
Nitin Seam, Trish Kritek and John Fleetham review their favorite podcasts discussions of important articles in AJRCCM in 2018.
Dr. John Fleetham is joined by Drs. Alison Lee and John Balmes to discuss the article "Prenatal Household Air Pollution is Associated with Impaired Infant Lung Function with Sex-Specific Effects: Evidence from GRAPHS, a Cluster Randomized Cookstove Interv
Trish Kritek is joined by Dr. Mitchell Levy to discuss his article Mortality Changes Associated with Mandated Public Reporting for Sepsis: The Results of the New York State Initiative
In Part 2 of this discussion of the 2018 ATS/ERS/JRS/ALAT Guideline, we discuss the approach to invasive procedures in suspected IPF and unanswered questions/directions of future research in IPF.
Dr. Nitin Seam moderates a discussion of the 2018 ATS/ERS/JRS/ALAT Guideline with authors Ganesh Raghu and Kevin Wilson. Part 1 discusses the history, how the guideline questions were formulated and the non-invasive workup.
Dr. Fleetham is joined by Drs. Julia Chapman and Sanjay Patel to discuss their respective article and editorial on alternatives to CPAP and the role Armodafinil could possibly play.
John Fleetham is joined by Chris Turnbull, lead author of the paper Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX): A Randomised, CPAP Withdrawal Trial.
Drs. Lorenzo Berra and Mark Gladwin join Nitin Seam to discuss an interesting trial looking at the effect of inhaled nitric oxide on hemolysis and renal failure post cardiac surgery
Dr. Trish Kritek is joined by Drs. Luciano Gattinoni and Taylor Thompson to discuss Gattinonis article on the topic.
Drs. Gerard Criner and Gaetan Deslee join Nitin Seam to discuss the results of the multi-center LIBERATE trial, the first endobronchial valve study to follow patients for 12 months.
Dr. Fleetham discusses phenotyping using polysomnography in patients with COPD with Drs. Scott Sands and David Rappoport
Dr. Wedzicha joins Nitin Seam to give her perspective on 3 important papers from the conference issue of the blue journal and to discuss some current and future articles of interest.
Drs. Atul Malhotra and Safwan Badr join Dr. Fleetham to discuss the article Research priorities in pathophysiology for sleep-disordered breathing (SDB)in patients with chronic obstructive pulmonary disease (COPD)
Nitin Seam discusses this phase II trial published in the Blue Journal with lead study author Dr. Yohanna Skorbik and Dr. Tim Girard
Dr. Trish Kritek is joined by Dr. Marc Moss to discuss the findings and implications of the article An Observational Study of the Efficacy of Cisatracurium Compared to Vecuronium in Patients with or at Risk for ARDS.
Drs. Gabor Kovacs and Brad Maron join Nitin Seam to discuss Mild Elevation of Pulmonary Arterial Pressure as a Predictor of Mortality, a paper Dr. Kovacs' group published in the February 2018 issue of the AJRCCM.
Dr. John Fleetham and Prof. Daiana Stolz, MD, MPH discuss the findings of Prof. Stolzs paper "Intensified therapy with inhaled corticosteroids and LABA at the onset of URTI to prevent COPD exacerbations".
Please listen to our podcast editors give their thoughts on some of the most interesting papers related to pulmonary, critical care and sleep medicine published in American Journal of Respiratory and Critical Care Medicine in 2017.
Recent evidence suggests that Obstructive Sleep Apnea (OSA) may be a risk factor for developing Mild Cognitive Impairment and Alzheimers disease. Dr. John Fleetham and author Ricardo Osorio discuss.
Dr. John Fleetham and Dr. Doug McEvoy discuss Dr. McEvoys paper on the effect of OSA treatment on renal function in patients with cardiovascular disease.
Dr. Nitin Seam is joined by Drs. Vincent Liu and Mervyn Singer to discuss Dr. Liu's paper "The Timing of Early Antibiotics and Hospital Mortality in Sepsis
Dr. Trish Kritek discusses the findings of this study with lead author Judith E. Nelson.
In this podcast, we review a comparison of outcomes in patients 65-74 years old from SEER-Medicare and NLST datasets in stage I lung cancer with study first author, Dr. Nichole Tanner as well as Dr. Neal Navani.
Disclaimer: audio for this episode is slightly distorted; we apologize for any inconvenience. Dr. Trish Kritek discusses the findings of this study with authors Biren Kamdar and Dale Needham.
Dr. John Fleetham sits down with Dr. Kennth Olivier to discuss the findings of his paper published in the AJRCCM this past March
In part two of the discussion, Drs. Eddy Fan and Nitin Seam discuss the clinical practice guideline recommendations as well as unanswered questions regarding high PEEP, recruitment maneuvers and ECMO in ARDS.
A conversation between Drs. Eddy Fan and Nitin Seam as they discuss the strong recommendations made in the important Clinical Practice Guideline published on mechanical ventilation in adults with ARDS as well as the areas of controversy or uncertainty.
Dr. John Fleetham speaks with Dr. Abd Tahrani to discuss his article Obstructive Sleep Apnoea and Retinopathy in Patients with Type 2 Diabetes: A Longitudinal Study.
Dr. Nitin Seam sits down to talk about the future of the Blue Journal with Editor-in-Chief Dr. Jadwiga Wedzicha and Deputy Editor Dr. Laurent Brochard.
Dr. John Fleetham sits down with Drs. Ayas and Bhattacharjee to discuss their editorial on sleep disordered breathing.
In celebration of the AJRCCMs 100 year anniversary, Dr. Trish Kritek sits down with Laurent Brochard to discuss the past, present, and future of critical care medicine.
In celebration of the AJRCCMs 100 year anniversary, Dr. John Fleetham sits down with Dr. Peter Calverley to discuss contributions the blue journal has made to the advancement of physiological research of COPD.
Dr. Loren Denlinger and Nitin Seam discuss the results of SARP-3 , a multi-center cohort study of adults and children with severe asthma. Dr. Denlinger describes the factors that were found to predict exacerbation-prone asthma.
Dr. Trish Kritek is joined by Dr. Todd Rice to discuss his article Balanced Crystalloids versus Saline in the Intensive Care Unit: The SALT Randomized Trial.
Blue Journal Editor Dr. Jadwiga Wedzicha joins Dr. Nitin Seam to discuss the newly published 2017 GOLD report. Dr. Wedzicha explains the major updates in the report regarding both diagnosis and management of patients with COPD.
Host Dr. Trish Kritek is joined by Dr. Punkaj Gupta to discuss the effectiveness of 24/7 in-house coverage on children suffering from critical illness.
Host Dr. John Fleetham is joined by Dr. Brad Edwards to discuss his studys findings that OA therapy improves the upper-airway collapsibility under passive and active conditions.
Nitin Seam discusses the results of the IMPACT trial with study author Ralf Eberhardt and author of a related editorial, Nick Hopkinson.
COPD expert Bartolome Celli joins Nitin Seam to discuss an analysis done by the COPD clinical biomarker consortium regarding the use of 6 minute walk distance as part of study enrollment as well as study outcome based on data from 11 clinical studies.
Dr. Nitin Seam is joined by Drs. Carolyn Calfee and John Marshall to continue the discussion on developing a new Sepsis definition. Listen in as they discuss the observations made in Dr. Calfees editorial.
In this weeks podcast, Dr. Trish Kritek is joined by Drs. Derek Angus and Christiane Hartog as they debate whether it is time for a new sepsis definition.
In the latest AJRCCM podcast, editor Trish Kritek talks to Drs. Marc Moss and Carol Hodgson about whether an intensive PT program would significantly improve long-term physical functional performance when compared to a standard-of-care PT program.
In this weeks installment of the AJRCCM Discussion Podcast, Dr. Nitin Seam is joined Drs. Peter Lange and Jadwiga Wedzicha as they discuss whether blood eosinophil levels serves as a useful biomarker predicting COPD exacerbation.
Dr. Nitin Seam discusses the novel findings of a study following a cohort of 2,865 patients with baseline polysomnography and clinical follow-up with study first author Dr. Sogol Javaheri and Blue Journal Associate Editor Dr. Najib Ayas.
Dr. Nitin Seam talks with Drs. Ulrich Costabel and Athol Wells about idiopathic pulmonary fibrosis and which patients may benefit from nintedanib treatment. They discuss the INPULSIS trials and Dr. Costabel's article in the January 15 issue of AJRCCM.
How does enrollment in a critical care trial affect patient outcome? Dr. Nitin Seam discusses what happened to eligible but non-enrolled patients in the OSCILLATE trial of mechanical ventilation in ARDS with Drs. Yaseen Arabi and Michael Lanspa.
Dr. Kaufman talks with Drs. Matthew Churpek and David H. Chong about the implications of the high prevalence of SIRS among patients hospitalized on general wards and what it means for sepsis surveillance, early warning systems, and CMS core measures.
Dr. Kaufman talks with Drs. Crotty-Alexander and Nasr about electronic cigarettes. What are they and what do they do? What dangers do they present? What should doctors and scientists know to evaluate this new nicotine delivery device?
Drs. T. Douglas Bradley, Joerg Steier, and Nitin Seam discuss the results of Bradleys study on ultrafiltration on a non-dialysis day in end stage renal patients with newly diagnosed sleep apnea
Dr. Nitin Seam and Dr. David Gozal discuss the latest "Beyond the Blue" about pediatric obstructive sleep apnea. Dr. Gozal served as the faculty mentor for the three fellows at the University of Chicago who reviewed three recent articles on pediatric OSA.
Drs. Stephen Rennard and Shawn Aaron discuss a manuscript from Dr. Rennard and his colleagues about using the CXCR2 antagonist MK-7123 to improve lung function in COPD. The podcast is moderated by AJRCCM podcast editor, Nitin Seam.
Dr. Nitin Seam chats with Dr. Mary Rice to discuss her group's finding that exposure to traffic emissions and fine particulate matter was associated with accelerated rate of lung function decline in a group of healthy adults.
Dr. Nitin Seam interviews Drs. Greet Hermans and Margaret Herridge discuss a new article written by Dr. Hermans and colleagues, which analyzes and describes acute outcomes and mortality in patients with ICU-acquired weakness.
Dr. David Kaufman interviews Drs. Salvatore Maggiore and Laurent Brochard about a study conducted by Dr. Maggiore and his colleagues comparing nasal high-flow therapy and Venturi mask oxygen therapy in patients following extubation.
Dr. Nitin Seam discusses the results of a novel study with Dr. Peter Leary and Dr. Meredith McCormack.
Dr. Nitin Seam discusses the NHLBI Workshop Report with Dr. Jerry Eu and Dr. Tim Blackwell
Dr. Christopher Slatore interviews Dr. Jerry Krishnan about the ATS Research Statement on Comparative Effectiveness Research
Dr. Timothy Vece interviews Dr. Geoffrey Kurland on a recent ATS Clinical Practice Guideline