The Stem Cell Podcast: Recent Episodes
The Stem Cell Podcast
Join Drs. Daylon James and Arun Sharma as they discuss the latest stem cell research, and interview some of the brightest minds in the field.
Guest:Nobel Laureate Dr. Shinya Yamanaka is the Director Emeritus of the Center for iPS Cell Research and Application (CiRA), President of the CiRA Foundation, Professor at Kyoto University, and Senior Investigator at the Gladstone Institutes. 20 years after the discovery of iPSCs, he discusses how his lab is advancing iPSC therapies toward the clinic while continuing to investigate the basic mechanisms underlying pluripotency, stem cell biology, and translation initiation. He also shares his vision for the future of regenerative medicine, the ethical challenges posed by emerging stem cell technologies, and the opportunities created by combining iPSC with advances such as CRISPR and organoids.
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The Stem Cell Science Round UpElephant iPS Cells – Researchers have generated the first induced pluripotent stem cells from Asian elephants, providing a new platform for conservation and disease research.
Epigenetic Cell Counter – Intestinal stem cells use an epigenetic division-counting mechanism to precisely control cell fate decisions during tissue maintenance.
Reversing Bone Marrow Aging – Long-term vitamin C supplementation partially reverses age-related changes in primate bone marrow and hematopoietic stem cell function.
Human Heart Atlas – A comprehensive atlas of human cardiac organoids reveals how signaling molecules regulate heart function and identifies pathways linked to heart failure.
Photo Reference: Courtesy of Dr. Shinya Yamanaka.
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Guest:In July 2026, we attended ISSCR 2026, the annual meeting of the International Society for Stem Cell Research, in Montreal. We spoke with delegates about their research, the scientific advances that stood out to them, and the emerging trends shaping the future of stem cell biology. They also reflect on their own conference highlights and the unique opportunities that meetings like ISSCR provide for collaboration, networking, and scientific discovery.
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Guest:In this special episode recorded live in Montréal, Canada at ISSCR 2026, Dr. Michael May, President and CEO of the Centre for Commercialization of Regenerative Medicine (CCRM), and Dr. Janet Rothberg, Senior Director of Process and Analytical Development at CCRM, explore how stem cell discoveries can be translated into commercially viable therapies through scalable manufacturing, company creation, investment, automation, and artificial intelligence. They emphasize the importance of considering manufacturing, quality control, market selection, reimbursement, and the evolving standard of care much earlier in the development process. They also share their vision for a future in which robust bioprocessing, better use of data, and improved regulatory and reimbursement models make iPSC-derived therapies more affordable and widely accessible.
Photo Reference: Courtesy of Drs. Michael May and Janet Rothberg
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Guest:In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting, where they discuss the challenges of making advanced cell and gene therapies accessible, the latest progress in organoids and regenerative medicine, and the importance of balancing ambitious clinical goals with rigorous scientific evidence. They also reflect on the meeting’s broader themes, from the enduring role of developmental biology and patient advocacy to the achievements of award recipients and the growing integration of new technologies such as AI, machine learning, and advanced imaging in stem cell research.
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Guest:In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes, where Daylon and Arun discuss advances in synthetic biology, organoid engineering, regenerative medicine, developmental biology, and AI-driven approaches to stem cell research. They also reflect on inspiring plenary talks covering topics from pregnancy-associated tissue adaptation and lung development to AI-powered drug discovery, while sharing their excitement about conversations with conference delegates and the rapidly evolving future of the field.
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Guest:In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes, where Daylon and Arun discuss promising stem cell clinical trial updates for Parkinson’s disease, advances in cardiac, thymus, and vascular organoid research, and new technologies that are reshaping developmental biology and regenerative medicine. They also reflect on inspiring patient stories, tributes to stem cell pioneer Sir John Gurdon, and the growing role of AI and engineering in the future of stem cell research.
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Guest:In July 2026, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Montreal, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss the opening plenary, major advances in iPSC research, organoids, CRISPR, and space biology, as well as their live podcast recording on translating stem cell research into real-world therapies. They also share their impressions of the meeting, memorable sessions, and the excitement of reconnecting with colleagues and the stem cell community.
Featured Products and Resources:* Learn about organoid culture from the experts at STEMCELL using the Organoid Information Hub.
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Guest:This special episode, created in partnership with the ISSCR Early Career Advisory Committee, features two rising leaders in stem cell research. Dr. Yifei (Simon) Miao, a Professor at the Chinese Academy of Sciences, discusses engineering vascularized organoids and integrating bioengineering approaches to build more physiologically relevant human tissues. Dr. Anca Pașca, an Assistant Professor at Stanford Medicine, explores how stem cell-derived brain organoids and assembloids are advancing our understanding of neonatal brain injury and neurodevelopmental disorders, with the goal of developing new therapies for vulnerable infants.
If you’d like to nominate yourself or a colleague for our Early Career Researcher Series, submit your nomination here.
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The Stem Cell Science Round UpEditing Early Human Development – Base editing of human embryos reveals that NANOG is essential for epiblast formation and human pluripotency.
Reprogramming Colorectal Cancer – Loss of GATA6 promotes colorectal cancer liver metastasis by driving multilineage cellular plasticity.
Precision Medicine for Pancreatitis – Patient-derived organoids identify chronic pancreatitis subtypes and reveal CFTR modulators as a potential treatment.
Tracking Heart Organoids – A wireless cantilever platform enables high-throughput measurement of contractile forces in human cardiac organoids.
Photo Reference: Courtesy of Drs. Yifei (Simon) Miao and Anca Pasca
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Guest:Dr. Mekayla Storer is an Associate Professor at the University of Cambridge and a Principal Investigator at the Cambridge Stem Cell Institute. She discusses how mammalian digit tips regenerate after injury, focusing on the formation of the blastema and the cellular and molecular mechanisms that distinguish regeneration from scarring. She highlights the role of the extracellular matrix, tissue mechanics, and regenerative microenvironments in directing tissue repair, and explores how insights from digit tip regeneration may inform strategies to promote regeneration in other organs.
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The Stem Cell Science Round UpModeling EMT in Human Cells – Scientists have developed a human iPSC-based platform that enables standardized, multimodal analysis of epithelial-to-mesenchymal transition dynamics across 2D and 3D contexts.
Modeling Persistent Ebola Infection – Human brain organoids reveal how persistent Ebola virus infection in neural cells drives long-term inflammation and viral evolution.
Reducing Retinal Graft Rejection – Transient JAK inhibition reduces immune rejection of stem cell-derived retinal grafts and improves visual recovery.
Enhancing Renal Regeneration – Targeting ENPP1 with a therapeutic antibody enhances regeneration and restores function after acute kidney injury.
Photo Reference: Courtesy of Dr. Mekayla Storer
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Guest:Dr. Filipa Simões is a Group Leader at the University of Oxford and Co-Director of the Oxford Organoid Hub. She discusses how macrophages shape heart development, repair, and regeneration, and how cellular crosstalk within the cardiac niche influences tissue outcomes after injury. Using zebrafish models, stem cell–derived cardiac organoids, and spatial genomics approaches, she explores the molecular signals that govern macrophage identity and function, with the goal of uncovering new strategies to promote cardiac regeneration and limit fibrosis.
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The Stem Cell Science Round UpiPSC Therapy for Heart Failure – Engineered heart muscle grafts derived from iPSCs increased heart wall thickness and improved cardiac function in patients with heart failure.
Inflammatory Memory in HSCs – A distinct human HSC subset retains inflammatory memory, influencing blood production, aging, and disease risk.
Organoid-Mediated Vision Recovery – Transplanted human retinal organoids partially restored vision after complete optic nerve transection in rats.
Improving HSPC Gene Therapy – A new selection strategy enriches precisely edited hematopoietic stem cells while reducing unwanted genomic alterations.
Photo Reference: Courtesy of Filipa Simões.
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Guest:Dr. Vijay Sankaran is a Professor at Harvard Medical School and Investigator at the Howard Hughes Medical Institute. He discusses how his lab uses human genetics and stem cell biology to uncover mechanisms regulating hematopoiesis and blood disease, including the discovery of key regulators such as BCL11A and HOTSCRAMBL. He also explores how advances in genome editing, stem cell engineering, and single-cell genomics are shaping new therapies for disorders such as sickle cell disease, thalassemia, and leukemia, while highlighting the challenges of translating these breakthroughs into scalable patient treatments.
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The Stem Cell Science Round UpBuilding Pancreatic Cancer Models – A stem cell-derived organoid model reveals genetic and epigenetic mechanisms driving human pancreatic cancer initiation.
Functional Cancer Stem Cell Assays – Researchers have developed a microwell platform that enables rapid enrichment of breast cancer stem cells for personalized drug testing.
Human Pacemaker Assembloids – A human cardiac assembloid model recreates neural control of pacemaker activity and atrial conduction.
Photo Reference: Courtesy of Dr. Vijay Sankaran.
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Guest:Dr. Meenal Datta is an Associate Professor at the University of Notre Dame and leader of the Tumor Immune Microenvironment Mechanics (TIME) Lab. She discusses how mechanical forces within tumors shape cancer progression and immune responses, with a focus on glioblastoma. She highlights how immunomechanics and mechanobiology influence tumor growth, treatment resistance, and immune cell function, and explores how space-based research and microgravity models can uncover new insights and therapeutic strategies for cancer.
Featured Products and Resources:* Join us at ISSCR 2026 and be part of the global conversation shaping the future of stem cell research. * Strengthen reproducibility of hPSCs with this free, on-demand training course offered by STEMCELL Technologies and the ISSCR.
The Stem Cell Science Round UpWhy the Heart Resists Cancer – Researchers have discovered that mechanical load in the heart suppresses cancer cell proliferation via mechanotransduction and chromatin remodeling.
HOTSCRAMBL Shapes Stem Cell Fate – A genetic variant disrupts the lncRNA HOTSCRAMBL, reducing HSC self-renewal and impairing leukemia growth.
AI-Driven Drug Repurposing – Deep learning and organoid screening identified azole drugs that rescue neuronal defects in Leigh syndrome.
Modeling the Menstrual Cycle – An organoid-based model recreates the menstrual cycle and identifies WNT7A as key for endometrial regeneration.
Photo Reference: Courtesy of Dr. Meenal Datta.
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Guest:Dr. Andrew Gaffney is Vice President, iPSC Platform at STEMCELL Technologies. In this episode, he discusses how his team is advancing pluripotent stem cell applications through high-quality iPSC line development, gene editing, organoid production, and GMP manufacturing for translational and clinical use. He also highlights key challenges in the field, including reproducibility, standardization, genetic diversity, and freedom-to-operate considerations, and explains how these factors impact the path from basic research to commercialization.
Featured Products and Resources:* + Explore STEMCELL Technologies’ one-stop resource for organoids. + Join us at ISSCR 2026 and be part of the global conversation shaping the future of stem cell research.
The Stem Cell Science Round UpTransgene-Free Gastrulation Model – Scientists have produced a transgene-free stem cell model that recreates key features of human peri-gastrulation, including germ layer formation and early hematopoiesis.
Engineering Antibody-Producing Stem Cells – CRISPR-edited hematopoietic stem cells generate B cells that produce durable, protective antibodies following vaccination.
Safeguarding Chemical Reprogramming – Investigators have found that p53 is required for efficient chemical reprogramming by maintaining genomic stability and regulating early cell state transitions.
Targeting Barriers to Cardiac Repair – Knockdown of calreticulin enhances cardiac reprogramming and improves heart repair after injury.
Photo Reference: Courtesy of Dr. Andrew Gaffney
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Guest:Dr. Kotaro Sasaki is an Associate Professor at the University of Pennsylvania. In this episode, he discusses how his lab uses human pluripotent stem cells to model germ cell development and endocrine organs such as the testis and adrenal gland. He highlights progress toward in vitro gametogenesis, including generating spermatogonial-like cells and reconstructing testicular environments, as well as recent advances in building adrenal organoids with zonal architecture. He also explores the scientific, translational, and ethical challenges of creating functional human gametes, and emphasizes the importance of developmental biology in guiding stem cell-based approaches.
Featured Products and Resources:* Get a free wallchart on the derivation and applications of hPSCs. * Take your human pluripotent stem cell cultures further with mTeSR™ Plus from STEMCELL Technologies.
The Stem Cell Science Round UpStage-Specific Cell Competition – Cell competition in gastruloids is stage-specific and driven by relative p53 levels during pluripotency exit.
Modeling Pediatric Brain Tumors – Scientists have enabled robust generation and drug testing of patient-derived pediatric brain tumor organoids.
Immune Reprogramming in Heart Failure – Engineered dendritic cells reduce cardiac fibrosis and improve heart function by modulating immune responses.
Overcoming Hypoxia in Islets – Inhibiting zinc transport enhances stem cell–derived islet survival and function by improving angiogenesis and hypoxia resistance.
Photo Reference: Courtesy of Dr. Kotaro Sasaki.
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Guest:Dr. Aitor Aguirre is an Associate Professor at Michigan State University and Director of the Stem Cell Core. In this episode, he discusses how his lab uses pluripotent stem cells and cardiac organoids to model human heart development and disease. He highlights the role of self-organization and bioengineering in building complex heart models, including assembloids with immune and neural components, and their applications in studying conditions like atrial fibrillation. He also shares perspectives on open science, collaboration, and training the next generation of scientists.
Featured Products and Resources:* Get a free wallchart on the directed differentiation of hPSCs. * Explore STEMCELL Technologies’ collection of technical videos and webinars on neurological disease modeling.
The Stem Cell Science Round UpModeling West Nile Encephalitis – Human cerebral organoids effectively model West Nile virus encephalitis and its associated neuronal damage and inflammation.
New Therapy for Leigh Syndrome – Researchers identified sildenafil as a potential treatment for Leigh syndrome.
Epigenetic Landscapes of Breast Cancer – Patient-derived organoids reveal epigenetic subtypes of breast cancer, including a metastasis-specific group.
Unexpected Totipotency in Hofstenia – Hofstenia embryos retain surprising totipotency and plasticity despite early fate-specifying cleavage.
Photo Reference: Courtesy of Dr. Aitor Aguirre
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Guest:Dr. Thorsten Boroviak is an Assistant Professor at the University of Cambridge and a member of the Cambridge Stem Cell Institute. He discusses how stem cell–based embryo models are helping researchers study early human and primate development, including implantation and gastrulation. He also talks about using primate systems such as marmoset to understand human development, the role of biomechanics and extraembryonic tissues in embryogenesis, and the ethical considerations surrounding embryo models and emerging technologies like in vitro gametogenesis.
Featured Products and Resources:* Explore a basic overview of organoids and resources to support your organoid culture. * Explore STEMCELL Technologies’ collection of technical videos and webinars on neurological disease modeling.
The Stem Cell Science Round UpMitophagy Controls Blood Stem Cells – Embryonic blood stem cells expand while staying multipotent thanks to tightly controlled ROS levels regulated by developmental mitophagy.
SLC4A3 Variants Drive Arrhythmia Risk – Mutations in SLC4A3 raise intracellular pH in heart cells, which shortens electrical signals and increases the risk of dangerous arrhythmias.
HSC Dynamics After Myeloablation – After chemotherapy, blood stem cells briefly boost differentiation to rebuild the blood system before returning to normal.
Modeling Duchenne Cardiomyopathy – Scientists generated heart organoids from Duchenne muscular dystrophy patient stem cells that mimic cardiomyopathy.
Photo Reference: Courtesy of Thorsten Boroviak.
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Guest:Drs. Shuibing Chen and Hans Clevers, members of the Steering Committee for the ISSCR Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development, discuss the need to accelerate the responsible integration of stem cell–derived models into preclinical drug development. Their conversation reflects growing regulatory and policy momentum around new approach methodologies (NAMs) and underscores the importance of rigorous standards, regulatory alignment, and cross-sector collaboration to improve reproducibility and advance more predictive, human-relevant therapies.
Building on its long-standing leadership in global standards, ethics, and policy, the ISSCR is uniquely positioned to convene industry, academia, and regulators around this effort. The initiative also reflects the Society’s expanding industry engagement, with industry membership increasing nearly 180% over the past five years – creating new opportunities for strategic partnerships to address shared scientific and translational challenges.
Featured Products and Resources:* + Learn how organoids can be used to expand clinical applications of diseases and disorders. + Get a free wallchart showing how organoids are used as model systems to study infectious diseases, cancer, congenital disorders, and tissue regeneration.
The Stem Cell Science Round UpTreating Frailty with Stem Cells – In a clinical trial, mesenchymal stem cell therapy improved walking distance and physical function in older adults with frailty.
Combined Bone & Bone Marrow Organoids – Researchers developed a scalable iPSC-derived bone marrow organoid that models human lympho-myeloid hematopoiesis and disease.
CAR-NK Progenitors Prevent Relapse – Engineered pluripotent stem cell–derived CAR-expressing NK progenitor cells reduced minimal residual disease and prevented relapse in leukemia models following chemotherapy.
Whole-Body Single-Cell Mapping – Scientists have developed a 3D single-cell-resolution map of mouse organs and the whole neonatal body.
Photo Reference: Courtesy of Drs. Shuibing Chen and Hans Clevers
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Guest:Drs. Fiona Doetsch and Nozomu Yachie, Co-Chairs of the ISSCR 2026 Annual Meeting Program Committee, join the podcast to discuss what to expect at the upcoming ISSCR 2026 meeting taking place in Montreal, Canada from July 8 – 11, 2026. This is the world’s largest and most comprehensive gathering dedicated to stem cell research and regenerative medicine, bringing together global leaders across basic science, technology development, translational research, and clinical application. They discuss the meeting’s global focus, program highlights, and spotlight the many new invited speakers and expanded opportunities for trainees to present and network.
Featured Products and Resources:* Explore STEMCELL Technologies’ collection of technical videos and webinars on neurological disease modeling. * Get a free wallchart showing how organoids are used as model systems to study infectious diseases, cancer, congenital disorders, and tissue regeneration.
The Stem Cell Science Round UpHCMV Infection and Cholangiocyte Barriers – Scientists show that human cytomegalovirus infection induces epithelial–mesenchymal transition in cholangiocytes.
Cross-Circulation for Liver Failure – Extracorporeal cross-circulation with genetically modified pig livers provided effective temporary liver support with minimal immune response in a human decedent model.
How Sleep Loss Hurts the Gut – Researchers identified a sleep deprivation-responsive neural circuit that controls intestinal stem cell function.
Mapping the Fetal Stem Cell Niche – Scientists demonstrate a central role of hepatoblasts in the regulation of fetal liver hematopoiesis and stem cell maintenance.
Photo Reference: Courtesy of Fiona Doetsch and Nozomu Yachie
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Guest:Dr. Joseph Wu is a Professor of Medicine and Radiology and the Director of the Stanford Cardiovascular Institute. He talks about the importance of pharmacology knowledge in drug discovery. He also discusses his early iPSC research, investigating vaccine-induced myocarditis, and embracing New Approach Methodologies (NAMs). (39:40)
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The Stem Cell Science Round UpAutism Genes in Organoids: Research provides new insight into the convergent impact of autism spectrum disorder genetic risk on human neurodevelopment. (2:35)
Pancreatic Organoid Screening: High-content screen reveals 54 compounds altering pancreatic organoid shape or differentiation. (13:15)
CRISPR Screening for Tauopathies: CRISPR screens in human neurons reveal modifiers of tau oligomer accumulation. (21:03)
Fixing Facial Scarring: Modulating ROBO2-EID1-EP300 signaling pathway promotes facial-like reduced fibrosis at scar-prone sites. (31:00)
Image courtesy of Dr. Joseph Wu
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Guest:Dr. Pinar Mesci is the Global Head of Biomanufacturing and Biotechnology at Axiom Space, where she manages a portfolio focused on biomedical research programs including stem cells, tissue engineering, disease modeling, cancer research, and DNA-inspired nanomaterials. She talks about her early career developing brain organoid models, transitioning to the space industry, and how microgravity affects biological systems. She also discusses the future of low Earth orbit research and how new technologies can be transferred back to Earth. (40:55)
Featured Products and Resources:* Submit your abstract for ISSCR 2026 by February 25th! * Take your human pluripotent stem cell cultures further with mTeSR™ Plus from STEMCELL Technologies.
The Stem Cell Science Round UpiPSC-Derived Ovarian Support Cells – Fertilo is an ovarian support cell product that improves the in vitro maturation rate of human oocytes. (1:25)
Culturing HSPCs Ex Vivo – A nanoengineered 3D system improves HSPC multi-lineage differentiation and engraftment capacity. (13:30)
Spinal Core Repair Scaffolds – A nanoengineered extrusion-aligned tract promotes axonal reconnection, synapse formation, and locomotor recovery after spinal cord injury. (22:50)
Vascularizing Retinal Organoids – Transient vascular support enhances survival of retinal ganglion cells in organoids. (32:14)
Image courtesy of Dr. Pinar Mesci
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Guest:Dr. Deepak Srivastava is the President of the Gladstone Institutes and Director of the Roddenberry Stem Cell Center. His lab is focused on the gene networks that guide cardiac development. He talks about their recent work investigating heart defects in Down syndrome and strategies for delivering therapies to the heart. He also talks about how to incentivize the development and commercialization of cell and gene therapies. (41:50)
Featured Products and Resources:* Submit your abstract for ISSCR 2026! * STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit
The Stem Cell Science Round UpHeart and Ganglion Development – Researchers fused human sympathetic ganglion organoids and heart-forming organoids to construct functional connections between the sympathetic ganglia and the heart. (2:38)
Periportal Liver Assembloids – Patient-specific periportal liver assembloids retain the histological arrangement, gene expression, and cell interactions of periportal liver tissue. (9:40)
PIEZO1 and Drug-Induced Cardiotoxicity – Restoring endothelial PIEZO1 protects against tyrosine kinase inhibitor-induced hypertension and cardiac dysfunction. (19:28)
Somite and Neural Tube Co-Development – Scientists developed human trunk-like structures that have morphologically organized somites and a neural tube that form through self-organized, endogenous signaling. (28:43)
Image courtesy of Dr. Deepak Srivastava
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Guest:Dr. Hans Clevers is a Professor of Molecular Genetics and Distinguished Group Leader at the University of Utrecht. In this episode, he discusses snake gut and lung organoids, transitioning from academia to industry, and the challenges and complexities of creating a cell therapy. (44:26)
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The Stem Cell Science Round UpComputers Made From Human Brain Cells – Researchers have shown that structured neuronal firing sequences appear in spontaneous activity of human and murine brain organoids. (2:37)
Organoids Replicate Vascular Pathology – Scientists have developed a blood vessel organoid model from Hutchinson-Gilford progeria syndrome-mutant hESCs. (12:01)
Effects of Spaceflight on Stem Cells – Analyses of nine astronauts before, during, and after three short-duration International Space Station missions shows space-associated stem cell hallmarks of aging and resilience. (21:14)
The Role of Lysosomes in HSC Aging – Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells. (33:25)
Photo Reference: Courtesy of Hans Clevers
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Dr. Thomas Vierbuchen is Assistant Professor of Developmental Biology at Memorial Sloan Kettering Cancer Center. In this episode, he talks about using PSCs to model neurodevelopmental processes. He also discusses his direct reprogramming work and his lab's recent study on OTX2 in gastrulation.
Dr. Sumru Bayin is a Group Leader at the Gurdon Institute at the University of Cambridge. She talks about her work on regeneration in the neonatal mouse cerebellum and how cerebellar interneurons differentiate. She also discusses organizing a workshop to facilitate collaborations in regenerative biology, and her memories of the late Sir John Gurdon.
Guest:Dr. Juan Melero-Martin is an Associate Professor and the Endowed Chair in Cardiac Surgery at Boston Children’s Hospital. His lab uses bioengineering principles to understand how vascular networks are formed and the mechanisms by which the vasculature modulates the engraftment and activity of various human stem cells. (42:03)
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The Stem Cell Science Round UpChromosomal Genes Linked to Heart Disease – Scientists identified HMGN1, a nuclear binding protein, as a key contributor to trisomy 21-related congenital heart defects. (1:46)
Questioning Common Technique for Assessing IVF Embryos – Live imaging of late-stage preimplantation human embryos suggests that abnormalities can arise at a later stage of development than previously thought. (14:14)
Vitamin C Protects Ovaries – Scientists have shown that oral vitamin C protects against ovarian aging in primates. (24:07)
Multi-Branching Cell Differentiation Trajectories – A new Hodge Laplacian model has advanced single-cell multimodal data analysis by providing highly reliable results for complex multi-branching trajectories. (33:58)
Photo Reference: Courtesy of Dr. Juan Melero-Martin.
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Guest:Dr. Carole LaBonne is the Erastus Otis Haven Professor of Molecular Biosciences at Northwestern University. Her lab studies the genesis of neural crest stem cells at the level of the signaling pathways and transcription factors that comprise the neural crest gene regulatory network. They also study how these mechanisms contribute to exit from pluripotency and the subsequent lineage restriction of neural crest cells to their derivative cell types that collectively define vertebrates. (39:45)
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The Stem Cell Science Round UpCreating Modified Cows and Sheep from Haploid Stem Cells – Scientists have successfully derived haploid androgenetic ESCs from cattle and sheep, and have developed a novel method to generate offspring from these cells. (4:33)
Embryonic Stem Cells from Birds – Researchers have succeeded in deriving and maintaining authentic ESCs from chickens and seven other bird species. (13:48)
Mutation Hotspots Reveal Spermatogonia Clonal Growth – As men age, harmful genetic mutations in sperm not only accumulate but are also favored during sperm production, giving them a reproductive advantage. (20:35)
Canine iPSC Technology – Researchers have established culture conditions for canine iPSCs. (31:10)
Photo Reference: Courtesy of Dr. Carole LaBonne
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Guest:Dr. Paul Tesar is the Director of the Institute for Glial Sciences and the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at Case Western Reserve University. His lab uses PSCs to model neurological development and disease with a specific focus on oligodendrocytes and astrocytes. He talks about his work on oligodendrocyte maturation, advancing research into the commercial and clinical sectors, and mentoring the next generation of scientists. (42:17)
Featured Products and Resources:* STEMdiff Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells. * Explore STEMCELL Technologies’ collection of technical videos and webinars on neurological disease modeling.
The Stem Cell Science Round UpSpatially Patterned Kidney Assembloids – Genome-edited kidney progenitor assembloids recapitulate hallmarks of human autosomal dominant polycystic kidney disease. (5:50)
Transposable Elements Controlling Cell Fate – This study highlights the role of transposable elements as mechano-response enhancer elements that control human cell fate and gene expression. (13:54)
Cardiac Injury Recovery – Targeting a remote injury response in a non-cardiomyocyte cell type rapidly promotes post-myocardial infarction recovery of non-regenerative hearts. (22:47)
Intestinal Fibrosis in Crohn’s Disease – A mouse model of creeping fat recapitulates key features of Crohn’s disease strictures. (31:40)
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Guest:Dr. Lars Velten is a Group Leader at the Centre for Genomic Regulation in Barcelona. He talks about his research on cell-state-specific enhancers in hematopoiesis and lineage tracing techniques to study blood aging. He also discusses combining generative AI with wet lab techniques and the advantages of risk-taking in basic research. (40:41)
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The Stem Cell Science Round UpHSPC Aging in Space – Spaceflight reduces telomere maintenance and HSPC self-renewal. (1:50)
Modeling Myelin Repair – Brain organoids with integrated microglia enabled the investigation of demyelination and remyelination. (14:45)
Gastric Cancer Organoids – Scientists identified ligand-receptor pairs likely to be involved in fetal HSC migration and maintenance. (25:55)
Gastroids to Model Stomach Development – This study reveals a principle for instructing gastric patterning and provides a platform for advancing knowledge of stomach organogenesis. (33:10)
Image courtesy of Dr. Lars Velten
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Guest:Dr. Alice Soragni is an Associate Professor at the University of California, Los Angeles. She talks about her work on patient-derived organoids and how they can be adapted for drug screening. She also discusses how she transitioned from structural biology to research on protein aggregation and rare diseases, and the current social media landscape for scientists. (45:20)
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The Stem Cell Science Round UpOptogenetic Control of Morphogen Production – Researchers established a model that recapitulates Sonic hedgehog-mediated patterning of the vertebrate neural tube. (4:17)
Oligodendrocyte Maturation – Reducing SOX6 levels unlocks oligodendrocyte maturation and myelination. (15:45)
CAR T Therapy for Kidney Disease – Targeting extracellular matrix-producing cells with CAR T therapy is a therapeutic strategy for chronic kidney disease. (24:44)
Lung Xenotransplantation – A lung from a gene-edited pig was transplanted into a brain-dead human recipient. (35:00)
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Guest:Dr. Zhongwei Li is an Associate Professor at the University of Southern California. His lab focuses on kidney organogenesis with translational applications of kidney regeneration and disease modeling. He talks about his work on PSC-derived nephron progenitors and drug discovery applications for polycystic kidney disease. (40:12)
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The Stem Cell Science Round UpChemically Induced Embryo Founder Cells: A small-molecule-only approach was used to induce mouse embryonic stem cells into embryo founder cells, which generated a mouse embryo model. (1:45)
Transgene-Free Embryo Models: Scientists generated transgene-free stem cell-based embryo models solely from mouse naïve PSCs. (13:25)
Hypoimmune CAR T Cells: Allogeneic hypoimmune CAR T cells do not induce an immune response in patients. (21:15)
Reconstructing PSC-Islets: PSC-islets comprising all five endocrine subtypes were reconstructed and transplanted into mice. (32:03)
Image courtesy of Dr. Zhongwei Li
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Guest:Dr. Mark Hatley is an Associate Faculty Member and Director of the Division of Molecular Oncology at St. Jude Children’s Research Hospital. His research focuses on the developmental origins and genetic mechanisms of pediatric rhabdomyosarcoma. He talks about his work on pediatric oncology and the mechanisms that differentiate normal development from cancer. He also discusses the role of PAX3-FOXO1 and DICER1 in tumorigenesis. (37:50)
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The Stem Cell Science Round UpTransplanting Allogeneic Beta Cells – Researchers transplanted genetically modified allogeneic donor islet cells into a man with long-standing type 1 diabetes. (1:37)
Pig Liver Xenotransplantation – RNA sequencing highlights how innate immune cells may affect thrombotic and immune pathways after liver xenotransplantation. (12:03)
Chemical Reprogramming – A new method generates hCiPS cells from both cord blood and adult peripheral blood cells. (21:10)
T Cell Development – Soluble Notch agonists support T cell development in suspension bioreactor culture. (27:30)
Image courtesy of Dr. Mark Hatley
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Guest:Dr. Jeanne Loring is a Co-Founder of Aspen Neuroscience and Professor Emeritus at Scripps Research. She talks about generating gametes from the functionally extinct northern white rhinoceros, Aspen’s early days and its recent clinical trial results for Parkinson’s cell therapy, and sending her own stem cells into space. She also discusses the need for genetic variation in iPSC lines. (46:23)
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The Stem Cell Science Round UpLack of Evidence for Transitional Cerebellar Progenitors – New analysis of single-cell RNA sequencing refutes the existence of transitional cerebellar progenitor cells. (1:50)
Organoid Vascularization – Vascularized organoids resemble human fetal lung and intestine features. (17:05)
Metabolic Profiling of HSPCs – Researchers presented the integrated metabolome, lipidome, and transcriptome of human adult HSPCs upon differentiation, aging, and acute myeloid leukemia. (28:40)
Blood Vessels in Liver Organoids – Scientists generated liver organoids that contain fully perfused human vessels with functional sinusoid-like features. (37:00)
Image courtesy of Dr. Jeanne Loring
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Guest:Dr. James Briscoe is a Group Leader at the Francis Crick Institute and Editor-In-Chief of Development. His lab uses an interdisciplinary approach, including mice, chicks, and other models, to study developmental dynamics. He discusses his lab’s work on human trunk formation and his role as an Editor-In-Chief. (44:55)
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The Stem Cell Science Round UpNeural Organoid Self-Organization – Researchers used live light-sheet microscopy to track organoid development. (1:30)
Lung Cancer Organoids – A gel-liquid interface co-culture model of lung cancer organoids represents immunotherapy results in lung cancer patients. (13:25)
Digital Reconstruction of Embryos – Scientists reconstructed full digital mouse embryos at single-cell resolution during early organogenesis. (22:00)
Rapid Generation of Vascular Organoids – A new vascular organoid platform has broad potential for vascular modeling, disease studies, and regenerative cell therapy. (32:17)
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In June 2025, we attended ISSCR 2025, the annual meeting of the International Society for Stem Cell Research, in Hong Kong. We spoke with delegates about their research, their impressions of the meeting, and the most memorable research presented. They also discussed their experiences exploring Hong Kong.
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Guests:Dr. Hongkui Deng is the Director of the Institute of Stem Cell Research at Peking University and Dr. Candice Liew is a Senior Scientist at Reprogenix Bioscience. In this special episode recorded in front of a live audience at ISSCR 2025 in Hong Kong, they discuss their groundbreaking study transplanting CiPSC-derived islets into a patient with type 1 diabetes. They talk about their approach to chemical reprogramming, immune tolerance, and the therapy’s impact on the first patient.
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Images courtesy of Drs. Hongkui Deng and Candice Liew
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In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting. Sessions focused on cell therapy for spinal cord injury, immunocompatible pig organs, and community engagement.
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In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes, where Daylon and Arun discuss research on cell therapy for inflammatory bowel disease and hearing loss. They also talk about Dr. Jacob Hanna's work on ex utero embryo culture, Dr. Paola Arlotta's research on long-term brain organoids, and Di Pan's insights into sponge regeneration.
In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes, where Daylon and Arun cover talks on animal models of regeneration and the public perception of in vitro gametogenesis. They also discuss work on CiPSCs for Type 1 diabetes therapy and growing pig-human chimeric embryos.
In June 2025, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hong Kong, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four episodes, where Daylon and Arun discuss updates from clinical trials for ALS, congenital heart disease, and Parkinson's disease. They also talk about the Presidential Plenary session, chaired by Dr. Valentina Greco.
Dr. Maneesha Inamdar is the Director of the Institute for Stem Cell Science and Regenerative Medicine and Professor at Jawaharlal Nehru Centre for Advanced Scientific Research. Her lab uses comparative models, including mice, Drosophila, stem cell lines, and gastruloids, to study developmental biology. She talks about using embryo models to investigate teratogenicity, prioritizing ethnically diverse cell lines, and representing Indian scientists in global discussions.
Dr. Jacqueline Barry is the Chief Clinical Officer at Cell and Gene Therapy Catapult, Dr. Kapil Bharti is a Senior Investigator at the National Eye Institute at the National Institutes of Health, and Dr. Jack Mosher is the Scientific Director at the International Society for Stem Cell Research (ISSCR). They discuss their work on the ISSCR's Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies. They talk about the need for consistency and rigor in cell therapy development, and how the document can be navigated and applied across jurisdictions.
Dr. Margaret "Peggy" Goodell is the Vivian L. Smith Chair in Regenerative Medicine and Director of the Stem Cell and Regenerative Medicine Center at Baylor College of Medicine. Her research focuses on HSC regulation and aging. She talks about her discovery of a side population of HSCs, as well as her work on DNMT3A mutation and clonal hematopoiesis of indeterminate potential. Finally, she discusses the rich research environment in Houston.
Drs. Sarah Teichmann is a Member of the Department of Medicine and Professor of Stem Cell Medicine at the Cambridge Stem Cell Institute. She talks about the plasticity of different cell types and developing whole-organ cell atlases for organs such as the thymus. She also discusses Human Cell Atlas project and overcoming skepticism in its early days. Finally, she talks about integrating computational and wet lab biology, and running an interdisciplinary research group.
Professor Hank Greely is the Deane F. and Kate Edelman Johnson Professor of Law and Professor, by courtesy, of Genetics at Stanford University. He is also the Director of the Stanford Center for Law and the Biosciences. He talks about his career path into bioethics and ethical considerations for organoids, bodyoids, and embryo models. He also discusses the potential future of reproduction, including gametogenesis, ectogenesis, and genetic selection and editing of embryos.
Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children's Mercy Hospital. His research focuses on producing patient-derived cellular models to develop functional precision medicine. He talks about using personalized antisense oligonucleotides to reverse disease phenotypes in organoid models of Duchenne muscular dystrophy. He also discusses his lab's personal connections to the rare disease community and the opportunities for collaborations with clinicians at Children's Mercy.
Dr. Valentina Greco is the President of the International Society for Stem Cell Research (ISSCR), and Professor of Genetics and Co-Chair of the Status of Women in Medicine at Yale University. Dr. Kathryn Cheah is an ISSCR Program Committee Co-Chair and Emeritus Professor and Chair of Biochemistry at Hong Kong University. Dr. Eugenia Piddini is also an ISSCR Program Committee Co-Chair and Professorial Research Fellow in Cell Biology and School Research Director at the University of Bristol.They talk about the upcoming ISSCR 2025 meeting in Hong Kong from June 11-14, 2025. They discuss the meeting's global focus, program highlights, opportunities for early-career researchers, and what they're looking forward to in Hong Kong.
Dr. Robert Zweigerdt is a Principal Investigator at Hannover Medical School, where his lab focuses on cardiac differentiation and the scalable culture of PSCs. He talks about regulating the lineage-specific differentiation of hPSCs and generating heart-forming organoids that mirror developmental cardiogenesis. He also discusses the importance of mentorship and the benefits of an international research group.
Dr. Giorgia Quadrato is Assistant Professor of Stem Cell and Regenerative Medicine at the University of Southern California. Her research focuses on brain developmental and neural organoids. She talks about protocols for generating cerebellar organoids, including those with functional Purkinje cells. She also discusses a transcriptomic atlas of neural organoids and the stem cell research landscape in California.
Drs. Andrew Elefanty and Elizabeth Ng are Senior Principal Investigator and Principal Investigator, respectively, at the Murdoch Children's Research Institute. In the Blood Development group, they aim to develop innovative cellular therapies for blood and cartilage-related diseases. They talk about their recent study deriving and transplanting HSCs, their work on reporter lines, and their collaborative lab setup.
Dr. Marius Wernig is a Professor of Pathology and a Co-Director of the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University, where his research interests include direct reprogramming and neurological disease modeling. He talks about his early work reprogramming neuronal cells from fibroblasts, adopting iPSCs, and growing his lab. He also discusses his recent research on cell therapy for brain and skin diseases, as well as his musical talents outside of the lab.
Guest:Dr. Jonathan Thomas "JT" is the President and CEO of the California Institute for Regenerative Medicine (CIRM), an organization that provides funding for stem cell research with the purpose of accelerating treatments for patients in need. He talks about working to ensure diversity in clinical trials and developing treatments that are affordable and accessible to patients. He also discusses the progress during the twenty years since CIRM's inception, training the next generation of scientists, and balancing support for basic and clinical research. (41:03)Featured Products and Resources:Register now for ISSCR 2025 in Hong Kong!Cell Quality Attributes of Human Pluripotent Stem CellsThe Stem Cell Science Round UpRegulating Naive Pluripotency – Scientists used a targeted rapid protein degradation system to show that GABPA is a master pluripotency regulator. (1:36)Skin Wound Healing – A spatiotemporal atlas of human skin wound tissues identifies FOSL1 as a critical driver of re-epithelialization. (11:50)Bone Marrow Stem Cell Niches – The bone marrow niche orchestrates hierarchy in stem cells and immune tolerance. (20:49)Synthetic Organizer Cells – Synthetic organizer cells self-assemble around stem cells and produce morphogens. (30:50)Image courtesy of Dr. Jonathan Thomas Subscribe to our newsletter!Never miss updates about new episodes.Subscribe
Dr. Milica Radisic is a Professor and Canada Research Chair at the University of Toronto. Her lab uses organ-on-a-chip engineering to mimic physiology of the heart, kidney, and vasculature for the purpose of modeling human disease and discovering more effective drugs. In this episode, she talks about the challenges of studying the heart and strategies to mature cardiomyocytes. She also discusses using macrophages to vascularize heart-on-a-chip platforms and enhance cardiac tissue function, sustainability considerations for microfluidic chips, and how these disease models can reduce the use of lab animals. Finally, she talks about starting a company to commercialize her lab's cardiac chip platform, the landscape for women entrepreneurs, and advice from her mentor, Dr. Bob Langer.
Dr. Cynthia "Cindy" Dunbar is National Institutes of Health (NIH) Distinguished Investigator and Chief of the Translational Stem Cell Biology Branch at the National Heart, Lung, and Blood Institute of the NIH. She talks about using macaques to study hematopoiesis and aging, and the challenges and considerations for using these models. She also discusses her collaborative study transplanting iPSC-derived cardiomyocytes into rhesus macaques, as well as the NIH's unique research environment and her musical talents outside of the lab.
Dr. Mansi Srivastava is Professor of Organismic and Evolutionary Biology at Harvard University and Curator of Invertebrate Zoology at the Harvard Museum of Comparative Zoology. Her lab uses distantly related species to study evolution and regeneration. She talks about establishing Hofstenia miamia, or the three-banded panther worm, as a model system. She also discusses her lab's work on adult stem cell lineage tracing and whole-body regeneration in Hofstenia, as well as her scientific outreach efforts.
Drs. Dina Radenkovic and Bruna Paulsen are Co-Founder & CEO and VP of Manufacturing and Therapeutic development at Gameto, a biotech company developing treatment solutions to improve women's reproductive health. Their lead platform, Fertilo, uses ovarian support cells to mature oocytes outside of the body with the goal of making IVF and egg freezing shorter, safer, and more effective.
Dr. Meritxell Huch is a Scientific Director at the Max Planck Institute of Molecular Cell Biology and Genetics and an Honorary Professor at the Technical University of Dresden. Her research focuses on liver and pancreas organoid models. She discusses a protocol for liver mesenchyme and ductal cell organoid co-culture and generating bipotent stem cells from the liver. She also tells her story of moving throughout Europe to pursue her scientific passions.
Dr. Samantha Morris is an Associate Professor of Medicine at Brigham and Women's Hospital and Associate Professor of Systems Biology at Harvard Medical School. She talks about dissecting and manipulating the genetic pathways that regulate cell identity. She discusses tools to measure cell fate transitions and incorporating in silico and in vitro experiments.
Dr. Alfonso Martinez Arias is the CREA Research Professor in the Department of Systems Bioengineering of the Universitat Pompeu Fabra in Barcelona. He talks about his path to developmental biology research and developing gastruloids to model human development. He also discusses standards for embryo models and his recent research on hematopoiesis.
Guest:Dr. Behzad Yeganeh is an Associate Scientist at the Children’s Hospital of Eastern Ontario Research Institute and the University of Ottawa. His work focuses on lung development and injury. He talks about neonatal lung diseases and the mechanisms that regulate autophagy and apoptosis.
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The Stem Cell Science Round UpCell Therapy for Type 1 Diabetes – Chemically induced PSC-derived islets were transplanted into a patient and led to insulin-independent glycemic control.
Giant Panda iPSCs – Primary fibroblast cells were isolated from the giant panda and used to generate iPSCs.
Pausing Blastocyst Development – Human blastoids under mTOR inhibition show a diapause-like response.
Sustaining Epithelial Cultures – Epithelioids are a facile, cost-effective method of culturing multiple mouse and human epithelia
Image courtesy of Dr. Behzad Yeganeh
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Guest:Dr. Dmitriy Sheyn is an Associate Professor in the Department of Orthopedics and Regenerative Medicine Institute at Cedars-Sinai Medical Center. His lab focuses on the development of stem cell therapies for multiple musculoskeletal disorders caused by acute injuries and aging. He talks about ways to model disc degeneration and tendon injuries. He also discuses his lab’s work on tendon differentiation and the mechanisms of low back pain.
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The Stem Cell Science Round UpSkin Transparency for Live Imaging – Researchers used tartrazine to make the skin of a live rodent temporarily transparent.
Muscle Regeneration – Scientists generated satellite cells from skeletal muscle tissue and transplanted them into mouse muscle.
Cardiac Assembloids – Scientists used PSC-derived cardiac assembloids to model the atrioventricular conduction axis and study complex disorders affecting heart rhythm.
Yamanaka Factors and Cellular Senescence – Partial cellular reprogramming improved health markers in mouse models of aging.
Image courtesy of Dr. Dmitriy Sheyn
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Guest:Dr. Ludovic Vallier is the W3 Einstein Strategic Professor for Stem Cells in Regenerative Therapies at the Berlin Institute of Health and a Max Planck Fellow at the Max Planck Institute for Molecular Genetics. His lab uses stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy. He talks about modeling non-alcoholic fatty liver disease and his lab’s pivot to SARS-CoV-2 research early in the pandemic. He also discusses how iPSCs could be used to regenerate the liver after injury.
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The Stem Cell Science Round UpEnhancing Compatibility in Interspecies Chimeras – Researchers used nanobody-antigen interactions to increase the chimerism of human PSCs in mouse embryos.
Single-Nucleotide RNA Sequencing for Brain Aging – Scientists uncovered different cellular trajectories and cell communities in Alzheimer’s disease and normal aging.
Glial Cells in Multiple Sclerosis – iPSC-derived multiple sclerosis models provide a unique platform for dissecting glial contributions to disease phenotypes.
Organoids to Model Spinal Trigeminal Nucleus Development – Scientists differentiated hPSCs into region-specific brain organoids.
Image courtesy of Dr. Ludovic Vallier
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Guest:Dr. Ziyuan Guo is an Assistant Professor of Pediatrics at the Center for Stem Cell & Organoid Medicine at Cincinnati Children’s Hospital. He talks about in vivo reprogramming and cell and gene therapy in neurodevelopmental and neurodegenerative disorders. He also discusses assembloids to model the blood-brain barrier and strategies for organoid vascularization.
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The Stem Cell Science Round UpModeling Celiac Disease – Scientists generated air–liquid interface duodenal organoids from celiac disease patients.
Intestinal Immuno-Organoids – Intestinal immuno-organoids can be used to study tissue-resident immune responses in tumorigenesis and other diseases.
Naive PSCs in the Blastocyst – A blastocyst motif substrate reverts mouse and human PSCs to a naive state in vitro.
Sensory Neuron Excitability – Schwann cell-secreted PGE2 promotes neuronal maturation and normal sensory function.
Image courtesy of Dr. Ziyuan Guo
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Guest:Dr. Irving Weissman is the Virginia and Daniel Ludwig Professor of Clinical Cancer Research and Professor of Pathology and Developmental Biology at Stanford University. Dr. Weissman was the first scientist to identify and isolate mammalian blood-forming stem cells in mice, and his work has contributed to the understanding of how a single hematopoietic stem cell can give rise to specialized blood cells. He talks about developing new treatments for metastatic breast cancer and severe combined immunodeficiency. He also discusses myeloid bias in aging and strategies for commercializing new therapies.
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The Stem Cell Science Round UpTracking Somitogenesis – Scientists used live imaging to track cellular and signaling dynamics during somite formation.
Modeling Interstitial Flow in the Intestine – Researchers constructed a micro-small intestine system to study the mechanisms underlying intestinal tissue development.
IL-11 Signaling in Aging – Inhibiting IL-11 extends the healthspan and lifespan of mice.
Mapping Brain Vasculature – Scientists constructed a molecular atlas of the developing fetal, adult control, and diseased human brain vasculature.
Image courtesy of Dr. Irving Weissman
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In July 2024, we attended ISSCR 2024, the annual meeting of the International Society for Stem Cell Research, in Hamburg, Germany. We spoke with delegates about their research, their impressions of the meeting, and the most memorable research presented. They discussed their experiences in Europe and where they would like to see the meeting go next.
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Guests:Dr. Davide Marotta is the Program Director for In-Space Biomanufacturing at the International Space Station National Laboratory. Dr. Catriona Jamieson is the Director of the Sanford Stem Cell Institute at the University of California, San Diego. In this special episode recorded in front of a live audience at ISSCR 2024 in Hamburg, Germany, they talk about the opportunities and challenges of working with stem cells in a microgravity environment, and what this could mean for the future of stem cell-based therapies. They discuss the challenges of culturing cells in space, the need for risk reduction and collaboration, and how microgravity affects stem cell growth and aging. They also discuss the opportunities that come with the growing popularity of private spaceflight.
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Images courtesy of Drs. Davide Marotta and Catriona Jamieson
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In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four episodes from the meeting. Sessions focused on stem cell research in space, regulation and ethical considerations for human embryo models, and developing therapies for SCID, epilepsy, and spinal cord injury. Daylon and Arun also discussed work on salivary gland organoids and patient advocacy in Parkinson’s disease research.
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In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four episodes from the meeting. Highlights from Day 3 include Dr. Yasuhiro Takashima’s work on bilaminoids, Dr. Clive Svendsen‘s talk on organoid models for ALS, Dr. Sharon Gerecht’s research on modeling the microenvironment, and Dr. Katsuhiko Hayashi’s work with gonadal organoids.
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In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four episodes from the meeting. Highlights from Day 2 include Dr. Helmuth Gehart’s work on mesothelioma organoids, Dr. Kyoko Miura’s research on aging in naked mole rats, and Dr. Mansi Srivastava’s talk on panther worms to study pluripotency during development.
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In July 2024, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Hamburg, Germany, and recorded daily episodes discussing highlights of the first day of the meeting. In this episode, they discuss the clinical focus of this year’s meeting and the President’s Symposium, including Dr. Magdalena Götz’s talk on organellar heterogeneity and “moonlighting” proteins. They also talk about sessions on stem cells in low earth orbit and computational biology, including Dr. Jonathan Weissman’s work on PerturbSeq and Dr. Matthias Lutolf‘s work on organoids on chips. Finally, they discuss a session on cultured meat.
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Guest:Dr. Valentina Greco is the Carolyn Walch Slayman Professor of Genetics and Co-Chair of the Committee on the Status of Women in Medicine at Yale University. Her research focuses on tissue homeostasis in the face of continuous cellular turnover, frequent injuries, and spontaneous mutations. She talks about her research on skin and hair follicle stem cells, the role of imaging techniques, and bridging science and art. She also discusses disease modeling and building an inclusive lab culture.
Featured Products and Resources:* Attend a live podcast show at ISSCR 2024. * The Stem Cell Podcast has been nominated for a People’s Choice Podcast Award! Vote now.
The Stem Cell Science Round UpNext-Generation Genome Editing – An RNA-guided recombinase enzyme enables the insertion, excision, or inversion of specific target DNA sequences.
Maintaining HSC Function – Researchers identified the transcription factor Nynrin as a crucial regulator of HSC maintenance by modulating mitochondrial function.
A Vascularized Heart-on-a-Chip – Primitive macrophages enhanced cardiac tissue functionality.
Brain Chimeroids – A new multidonor human brain cortical organoid model was generated by co-developing cells from a panel of individual donors in a single organoid.
Image courtesy of Dr. Valentina Greco
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Guest:Dr. Sara Vasconcelos is a Senior Scientist and the John Kitson McIvor Endowed Chair in Diabetes Research at University Health Network. She is also an Associate Professor at the Institute of Biomedical Engineering at the University of Toronto. Her lab studies microvascular regeneration in cardiovascular diseases and diabetes, and are working to develop personalized patient-derived organ-chip models for drug screening and other applications. In this episode, she talks about modeling cardiac fibrosis and studying pancreatic islet vasculature. She also discusses working with microchips and with large animal models.
Featured Products and Resources:* It’s almost time for ISSCR 2024! Check out the program here. * Use STEMCELL’s STEMdiff™ Cardiomyocyte media and supplements to differentiate, enrich, expand, and cryopreserve functional hPSC-derived cardiomyocytes.
The Stem Cell Round UpGene Editing Lung Stem Cells – Scientists used a lipid nanoparticle delivery system to correct mutations in a mouse model of cystic fibrosis.
Trophectoderm Expansion – The polar trophectoderm thickens substantially before the expected time of implantation.
Liver Regeneration – Mouse hepatocytes required a functional electron transport chain to proliferate and compete with wild-type hepatocytes during liver regeneration.
Revascularizing Limbs – Proangiogenic/arteriogenic monocytes increased circulation in patients with chronic limb-threatening ischemia.
Image courtesy of Dr. Sara Vasconcelos
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Guest:Dr. Sebastian Diecke is a Group Leader and Stem Cell Core Director at the Max Delbrück Center, where his research focuses on iPSCs and organoid models. He talks about the early days of iPSC research, developing organoids from endangered rhinoceros, and modeling Huntington’s and other diseases.
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The Stem Cell Science Round UpBlood Self-Renewal – Researchers identified a crucial regulator that modulates endocytosis and environmental sensing in hematopoietic stem cells.
Cardiomyocytes After Heart Attack – iPSC-derived cardiomyocytes were successfully engrafted into two rhesus macaques with small, subclinical chronic myocardial infarctions.
CHIP and Gum Disease – DNMT3A-driven clonal hematopoiesis of indeterminate potential (CHIP) and inflammatory bone loss are reversed by rapamycin.
Turtle Liver Organoids – Scientists developed and characterized adult stem cell-derived turtle liver organoids.
Image courtesy of Dr. Sebastian Diecke
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Guest:Dr. Shukry Habib is an Associate Professor in the Department of Biomedical Sciences at the Université de Lausanne. His lab works at the intersection of stem cell biology, biophysics, and tissue engineering to investigate how tissues form. He talks about developing a transplantable bandage for bone repair and the role of Wnt signaling and cytonemes in development.
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The Stem Cell Science Round UpUnequal Blastomere Contribution – Prospective lineage tracing of human embryos revealed that the majority of the epiblast is derived from only one 2-cell stage blastomere.
Epigenetic Reprogramming of Germ Cells – Epigenetic reprogramming resets parental epigenetic memories and differentiates primordial germ cells into mitotic pro-spermatogonia or oogonia.
Blood-Brain Barrier Organoids – Researchers used patient-derived blood-brain barrier assembloids to model cerebral cavernous malformations.
Treating Genetic Liver Disease – A new study combines ex vivo large-scale cell expansion and gene editing in patient-derived transplantable hepatocytes, which holds potential for treating human liver diseases.
Image courtesy of Dr. Shukry Habib
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Guest:Dr. Shankar Srinivas is a Professor of Developmental Biology in the Department of Physiology Anatomy and Genetics based in the Institute for Developmental and Regenerative Medicine at the University of Oxford. He is also a Zeitlyn Fellow and Tutor in Medicine at Jesus College. Using mouse and human embryos as model systems, his group looks at the control of patterning and morphogenesis during the establishment of the anterior-posterior axis, gastrulation, and early cardiogenesis. He discusses how tissues respond to forces during early development, characterizing cardiac progenitors, and training internationally.
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The Stem Cell Science Round UpRat Forebrain Tissues in Mice – Reconstituted rat forebrains in mice exhibit normal structure and function.
Interspecies Neural Circuits – Rat stem cells develop in mouse blastocysts to broadly populate two-species brains.
Human Embryo Compaction – Researchers mapped cell surface tensions during compaction.
Cell Crowding in the Stem Cell Epithelium – In human embryonic stem cells, cellular crowding leads to the blockade of FGFR1 endocytosis.
Image Courtesy of Dr. Shankar Srinivas
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Guest:Dr. Pierre Vanderhaeghen is a Professor and Principal Investigator at VIB-KU Leuven Center for Brain & Disease Research. His lab studies the mechanisms of cortical development and brain evolution. He talks about the species-specific neuronal development, human neuron excitability, and playing in a rock cover band!
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The Stem Cell Science Round UpModeling Cancer Ex Vivo – Induced mini-colons recapitulated hallmarks of colorectal tumors.
Human Embryo Gastrulation – Scientists reconstructed a 3D model of a gastrulating human embryo using spatial transcriptomics.
Treating Timothy Syndrome – Antisense oligonucleotides rescued defects in patient-derived cortical organoids.
Sympathetic Neurons in Jawless Vertebrates – Scientists identified trunk sympathetic neurons in the sea lamprey.
Image courtesy of Dr. Pierre Vanderhaeghen
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Guest:Dr. Ryan Flynn is a Principal Investigator at Boston Children’s Hospital and an Assistant Professor in the Stem Cell and Regenerative Biology Department at Harvard University. His lab explores the interface between RNA and glycans. He talks about the discovery of glycoRNA and the chemistry of the RNA-glycan connection. He also discusses the effects of glycans on stem cell function and deciding between a career in medicine and basic science.
Featured Products and Resources:* Register now for ISSCR 2024, happening July 10-13 in Hamburg, Germany. * Listen to the Lab Coats & Life™ Podcast to stay informed about useful soft skills and relevant trends to help you thrive as a scientist.
The Stem Cell Science Round UpModeling Traumatic Brain Injury – Researchers used mechanically injured organoids to identify a target to reduce neuronal death after brain injury.
Spinal Cord Organoid Regeneration – The regenerative capabilities of the neonatal spinal cord may be due to proteins in the extracellular matrix.
HSC Transplantation to Treat HIV – Scientists developed a gene editing strategy targeted for autologous HSPC transplantation as a functional cure for HIV.
Hepatocyte Organoids to Treat Liver Failure – Encapsulated liver organoids rescued mice from liver failure.
Image Courtesy of Dr. Ryan Flynn
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Guest:Dr. Blair Benham-Pyle is an Assistant Professor at Baylor College of Medicine. She talks about how multipotent cells in Schmidtea mediterranea enable whole-body regeneration. She also discusses the effects of the mechanical environment on stem cell fate.
Featured Products and Resources:* Register for ISSCR 2024! * Get updates about new mentorship content from Lab Coats & Life™
The Stem Cell Science Round UpAntibodies to Rejuvenate the Immune System – Depleting myeloid-biased HSCs in aged mice restores features of a more youthful immune system.
Infant Intestinal Perforation and Brain Injury – Scientists identified subventricular zone echogenicity on cranial ultrasound in preterm infants following intestinal perforations.
Cell Fate in Brain Development – Researchers studied fate decisions in cerebral organoids and early fetal tissue.
Autofluorescence in Neural Stem Cells – Quiescent and activated neural stem cells have unique autofluorescence profiles.
Image courtesy of Dr. Blair Benham-Pyle
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Guests:Dr. Amander Clark is the President of the International Society for Stem Cell Research (ISSCR) and Founding Director of the Center for Reproductive Science, Health, and Education at the University of California, Los Angeles. Dr. Agnete Kirkeby is a Program Chair of the ISSCR Annual Meeting, Associate Professor at Lund University and the University of Copenhagen, and Group Leader at the Novo Nordisk Foundation Center for Stem Cell Biology – reNEW. Dr. Malin Parmar is a Program Chair of the ISSCR Annual Meeting, Professor at Lund University, and a New York Stem Cell Foundation – Robertson Investigator.
They talk about the upcoming ISSCR 2024 meeting in Hamburg, Germany from July 10-13, 2024. They discuss the meeting’s clinical focus, spotlight and plenary sessions, and opportunities for students and postdocs.
Featured Products and Resources:* Submit your abstract for ISSCR 2024! * Get updates about new mentorship content from Lab Coats & Life™
The Stem Cell Science Round UpHypoblast Development in the Embryo – Scientists examined post-implantation signaling interactions using human embryos and stem cell models of the epiblast and hypoblast.
Retinoic Acid in Tissue Regeneration – Manipulating retinoid availability in skin and in culture allowed researchers to direct stem cells to heal wounds or to make hair.
Human Heart Development – Researchers developed a spatial map of the developing human heart.
Bioprinting Cardiac Tissues – hPSC-atrioventricular canal cardiomyocytes can delay electrical impulse in 3D bioprinted tissue.
Image courtesy of Drs. Amander Clark, Agnete Kirkeby, and Malin Parmar
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Guest:Dr. Marissa Scavuzzo is an HHMI Hanna H. Gray Fellow at Case Western Reserve University School of Medicine. Her research focuses on enteric glia regulation in the healthy and diseased gut. She talks about how glial cell subtypes affect intestinal motility and her experience receiving NYSCF and HHMI fellowships. She also talks about bringing science to underserved schools in Cleveland.
Featured Products and Resources:* Submit your abstract now for ISSCR 2024! * Learn about mentorship and careers in science by listening to the new Lab Coats & Life™ Podcast.
The Stem Cell Science Round UpAstrocytes in Organoids – Researchers generated a cortical organoid platform to investigate human astrocyte function.
SOX17 in Immune Evasion – Scientists used AKP organoids to demonstrate that SOX17 orchestrates immune evasion in the early steps of colon cancer.
Bone Marrow Organoids – Bone marrow organoids model aspects of hematopoietic development and inborn errors of hematopoiesis.
Patient-Derived Lymphoma Organoids – Patient-derived lymphoma organoids recapitulate the tumor lymphoid microenvironment.
Image Courtesy of Dr. Marissa Scavuzzo. Photographer: Jesse Zhan
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Guest:Dr. Ritu Raman is the d’Arbeloff Career Development Assistant Professor of Mechanical Engineering at MIT, where her lab uses robotics and tissue engineering to treat muscle loss. She talks about light-activated muscle grafts, magnetic microparticles to control forces exerted on cells, and strategies for science communication.
Featured Products and Resources:* Register now for ISSCR 2024, happening July 10-13 in Hamburg, Germany. * The Lab Coats & Life™ Podcast features conversations about useful soft skills, relevant trends, and important efforts from within the scientific community to help you thrive as a scientist. Listen now!
The Stem Cell Science Round UpCell Therapy for COPD – Researchers conducted an early, open-label clinical trial of autologous P63+ lung progenitor cells for the treatment of patients with COPD.
Primary Hypoimmune Islets in Non-Human Primates – Hypoimmune pseudo-islets engraft and achieve insulin independence in a fully allogeneic monkey.
Modeling Proteinopathies in Neural Stem Cells – Scientists developed a model of neural networks to study ALS and frontotemporal lobar degeneration.
An Interactive Cardiomyocyte Exhibit – In a museum exhibit, visitors can synchronize live stem cell-derived cardiomyocytes’ beat rate to their own heartbeat in real time.
Image Courtesy of Dr. Ritu Raman
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Guest:Dr. Shiri Gur-Cohen is an Assistant Professor of Medicine in the Division of Regenerative Medicine at UC San Diego. Her lab studies epithelial stem cells throughout their lifetimes. She talks about lymphatics in the intestinal stem cell niche, 3D imaging techniques, and sharing her science with a wider audience.
Featured Products and Resources:* Submit your abstract for ISSCR 2024! * Get updates about new mentorship content from STEMCELL.
The Stem Cell Science Round UpNon-Invasive Organoid Monitoring – Flexible electronics enable chronic recording of cortical organoids for up to 120 days while preserving their morphology, cytoarchitecture, and cell composition.
Human Neuronal Maturation – Researchers identified an epigenetic developmental program that sets the timing of human neuronal maturation.
The Gut-Liver Axis and Intestinal Stem Cells – Liver-derived pigment epithelium-derived factor restrains intestinal stem cell proliferation.
Recovery After Lung Infection – The TGF-β receptor 2 is important for lung endothelial cells to recover after injury due to influenza virus or SARS-CoV-2 infection.
Image Courtesy of Dr. Shiri Gur-Cohen
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Guest:Dr. Malin Parmar is a Professor at Lund University and a New York Stem Cell Foundation – Robertson Investigator. Her research aims to understand cell fate specification in the developing brain and in human neural progenitor cells using cell-based models of neuronal differentiation. She talks about using assembloids to model the dopaminergic system, direct reprogramming somatic cells into induced neurons, and developing ESC-derived dopamine progenitor cells to treat Parkinson’s disease.
Featured Products and Resources:* Submit your abstract for ISSCR 2024 before February 14th! * STEMdiff™ Neural Crest Differentiation Kit creates a serum-free medium for differentiation of hESCs and iPSCs to neural crest cells.
The Stem Cell Science Round UpFetal Brain Organoids – Human fetal brain organoids display cellular heterogeneity and can be expanded.
SARS-CoV-2 in the Brain – hPSC-derived dopaminergic neurons are susceptible to SARS-CoV-2 infection.
Conjuctiva Organoids – Human conjunctiva organoid cultures enable the study of conjunctival (patho)-physiology.
Zebrafish Heart Regeneration – Scientists identified epicardial enhancer elements with specific activity during zebrafish development or during adult heart regeneration.
Photo Reference: Courtesy of Dr. Malin Parmar
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Guest:Dr. Olivier Pourquié is the Frank Burr Mallory Professor of Pathology and Professor in the Department of Genetics at Harvard Medical School. His work focuses on the segmentation clock and the development of muscles and vertebrae. He talks about studying somitogenesis in vitro and his work on brown fat development.
Featured Products and Resources:* Register now for ISSCR 2024! * Derive and expand with MyoCult™-SF Expansion Medium.
The Stem Cell Science Round UpA GENtoniK Cocktail – A small molecule cocktail accelerates the maturation of hPSC-derived neurons.
Pancreatic Cancer Organoids – Researchers identified a compound that can inhibit the growth and induce cell death of pancreatic organoids carrying a KRAS mutation.
Multilineage Mammary Organoids – Multilineage ESC-derived mammary organoids contain mammary-specific epithelial cells, fibroblasts, and adipocytes, and can produce milk.
Chimeric Super-SOX – The Yamanaka cocktail upgraded with Sox2-17 enhanced iPSC generation in five species.
Photo Reference: Courtesy of Dr. Olivier Pourquié
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Guests:Dr. Hwee Goon Tay is an Assistant Professor at the Duke-National University of Singapore Medical School and Dr. Beau Fenner is an Ophthalmologist at the Singapore National Eye Centre. Their work focuses on cell therapy for degenerative retinal diseases. They talk about strategies to slow degeneration and potentially restore vision.
Featured Products and Resources:* Enter to win up to $500 USD towards your registration fee for a cell and gene therapy conference. * Explore STEMCELL Technologies’ resources on PSC quality.
The Stem Cell Round UpA Hypoblast from hPSCs – Researchers used genetic and non-genetic approaches to generate authentic hypoblast cells from naïve hPSCs.
Culture Conditions for Mouse and Monkey Stem Cells – Stem cell co-cultures reveal crosstalk between embryonic and extraembryonic lineages.
Modeling Parkinson’s and Addiction – Scientists developed midbrain–striatum–cortical organoids that enable investigations into the human dopaminergic system.
Multi-Chamber Cardioids – A human cardioid platform recapitulates the development of all major embryonic heart compartments.
Photo Reference: Courtesy of Drs. Hwee Goon Tay and Beau Fenner
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Guest:Dr. Jose Polo is a Professor of Epigenetics and the Director of the Centre for Epigenetics at the University of Adelaide. He is also a Professor in the Department of Anatomy and Developmental Biology at Monash University. His lab studies the transcriptional and epigenetic mechanisms that govern cell identity. He talks about his team’s work on cell fate, iBlastoids, and placental models for SARS-CoV-2.
Featured Products and Resources:* Enter to win up to $500 USD towards your registration fee for a cell and gene therapy conference. * Explore STEMCELL Technologies’ resources for organoid research.
The Stem Cell Science Round Up
A Chimeric Monkey – Scientists produced the first live-born chimeric non-human primate to have a high proportion of cells originating from donor stem cells.
Norepinephrine Neurons – Researchers generated locus coeruleus norepinephrine neurons from human pluripotent stem cells, enabling the investigation of their roles in psychiatric and neurodegenerative diseases.
Mice with Rat Hearts – Intraspecies blastocyst complementation generated a functional cardiovascular system in mice.
Cancer Risk in Gene Therapy – Scientists identified genetic drivers that could increase leukemia risk in gene therapy trials for sickle cell disease.
Photo Reference: Courtesy of Dr. Jose Polo
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Dr. Stefan Irion is the Chief Scientific Officer of BlueRock Therapeutics and Dr. Viviane Tabar is the Chair of the Department of Neurosurgery at Memorial Sloan Kettering Cancer Center. In this special episode, recorded in front of a live audience in New York, they talk about their work on BlueRock's clinical trial for bemdaneprocel — a stem cell-derived investigational cell therapy for Parkinson's disease. They also discuss what's next for cell therapy and diversity in science and in patients.
Dr. Helen Blau is the Donald E. and Delia B. Baxter Foundation Professor and Director of the Baxter Laboratory for Stem Cell Biology at Stanford University. Dr. Blau’s research focuses on the basic molecular mechanisms of stem cells and muscle and their application to aging, regenerative medicine, and disease. Her lab aims to understand and apply biology to improve quality of life, and their current primary focus is on understanding the gerozyme 15-PGDH. She talks about the roles of NSAIDs and CD47 in muscle regeneration. She also discusses growing cultured meat and writing a children's book!
Dr. Roger Foo is the Zayed bin Sultan Al Nahyan Professor of Medicine and Head of the Cardiovascular Research Institute at the National University of Singapore. His lab investigates the molecular mechanisms that regulate cardiac biology and disease. He talks about the genetics of heart disease and the roles of circular RNAs.
Dr. Bas Trietsch is the Chief Technology Officer and Co-Founder at Mimetas, a company working to contribute to groundbreaking therapies with their screenable, physiologically relevant 3D human disease models. He talks about tissue-relevant models for drug discovery, and how organ-on-a-chip technology can help address scalability and reproducibility.
Dr. Thorold Theunissen is an Assistant Professor of Developmental Biology at Washington University in St. Louis investigating the molecular basis of pluripotency, the mechanisms of trophoblast development, and the generation of stem cell-based embryo models.
Guest:Dr. Nicolas Rivron is a Principal Investigator at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences in Vienna. His group recreates embryonic development using mammalian stem cells in a dish to better understand the encoded principles of self-organization. He talks about building human blastoid models and using them to study implantation. He also discusses differences in development between mice and humans, trophectoderm stem cells, and an ethical framework for embryo models.
Featured Products and Resources:* Keep current with the latest in ESC and iPSC news. * Download a free e-book on organoid research
The Stem Cell Science Round UpCell Therapy for Parkinson’s Disease – A Phase I trial showed safety, tolerability, and an improvement in dyskinesia symptoms.
CRISPR for Sickle Cell Disease – CRISPR-Cas9 disruption of the HBG1 and HBG2 gene promoters was an effective strategy for induction of fetal hemoglobin.
A Universal CAR T Cell Therapy for Blood Cancers – Epitope-edited CAR T cells were effective against patient-derived acute myeloid leukemia, B cell lymphoma, and acute T cell leukemia.
Transient-Naive-Treatment Reprogramming – A new reprogramming strategy produces hiPSCs with similar epigenetic and functional profiles to human embryonic stem cells.
Photo Reference: Courtesy of Dr. Nicolas Rivron
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Guests: Dr. Laura Andres-Martin is a Research Investigator, Oncology, Dr. Daniel Paul is the Senior VP, Discovery & Platform Development, and Dr. Raeka Aiyar is the VP, Scientific & DEIB Outreach at the New York Stem Cell Foundation (NYSCF). This episode was recorded live and in-person at the NYSCF Research Institute. The panelists talk about NYSCF's approach to automation, their women's reproductive cancer initiative, and promoting inclusion and belonging in science. They also talk about Founder Susan Solomon's legacy and future plans to break down barriers in stem cell research. Photo Reference: Courtesy of NYSCF
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Dr. Nathaniel Huebsch is an Assistant Professor of Biomedical Engineering at Washington University in St. Louis. His lab focuses on understanding how mechanical cues originating at cell-cell and cell-extracellular matrix contacts influence signaling and fate. They are especially interested in how those cues affect heart development and disease. He talks about cardiac models and cardiomyocyte maturity.
Guest: Dr. Thomas Durcan is an Associate Professor and Director of the Early Drug Discovery Unit at the Montreal Neurological Institute. He oversees a team of 40+ research staff and students, committed to applying patient-derived stem cells towards the development of phenotypic discovery assays and 3D neuronal organoid models for neurodegenerative and neurodevelopmental disorders. He talks about modeling sporadic ALS in a dish, partnering with the Michael J. Fox Foundation, and promoting open science. Featured Products and Resources:
See the Stem Cell Podcast live at the New York Stem Cell Foundation! Learn about the STEMdiff™ Cerebral Organoid Kit from STEMCELL Technologies
The Stem Cell Science Round Up SARS-CoV-2 in the Placenta – Researchers developed induced trophoblast stem cell models to study placental models of infection. Hematopoietic Stem and Progenitor Cells in the Embryo – Loss of microRNA-128 in zebrafish leads to an expansion of hematopoietic stem and progenitor cells in the aorta–gonad–mesonephros. Cochlear Organoids – Derived hair cells exhibit cochlear-like structural and functional properties. Cell Replacement in a Chimeric Mouse Brain – Old or diseased human glial cells in the chimeric mouse brain are eliminated by transplanted young cells. Photo Reference: Courtesy of Dr. Thomas Durcan
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In June 2023, we attended ISSCR 2023, the annual meeting of the International Society for Stem Cell Research, in Boston. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending, what they were most looking forward to, and the most memorable research presented.
Dr. Thomas Zwaka is the Director of the Huffington Center for Cell-Based Research in Parkinson's Disease and a Professor of Regenerative and Developmental Biology at the Icahn School of Medicine at Mount Sinai. His research focuses on fundamental questions surrounding stem cell biology, including how to reverse the process of differentiation and “re-program” any given cell type into a pluripotent stem cell.
In June 2023, Daylon and Arun attended the International for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the final day of the meeting.
In June 2023, Daylon and Arun attended the International Society for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the second day of the meeting.
In June 2023, Daylon and Arun attended the International Society for Stem Cell Research’s (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the second day of the meeting.
In June 2023, Daylon and Arun attended the International Society for Stem Cell Research's (ISSCR) annual meeting in Boston, Massachusetts, and recorded daily episodes discussing highlights of the first day of the meeting. They discuss the pre-meeting workshops, including Arun's own talk on stem cell research in space, as well as highlights from the morning's focus sessions and innovation showcases. They also dive into the Presidential Symposium and the new technologies presented in Plenary II.
Dr. Emma Rawlins is a Senior Group Leader at the Gurdon Institute in the Department of Physiology, Development, and Neuroscience at the University of Cambridge. She talks about modeling fetal lung development using organoids, using single-cell RNA sequencing to create a human lung fetal atlas, and her advice to trainees to follow their hearts.
Guest:Dr. Insoo Hyun is the Director of the Center for Life Sciences and Public Learning at the Museum of Science in Boston, and a Member of the Harvard Medical School Center for Bioethics. He talks about embryo models for early development, his work on the ISSCR’s guidelines for stem cell research, and advances in reproductive medicine.
Featured Products and Resources:* Meet the hosts of the Stem Cell Podcast at ISSCR 2023! * Explore career opportunities at STEMCELL.
The Stem Cell Science Round UpA New Small Molecule for Neuroregeneration – Scientists identified a PI3Kα activator that induces cell proliferation, provides cardioprotection, and stimulates nerve regeneration.
Zebrafish Heart Regeneration – Researchers used ex vivo imaging to visualize intracellular calcium dynamics in the regenerating zebrafish heart.
Signaling Pathways and Cell Fate – Scientists used optogenetics to study how ERK and AKT dynamics affect mouse embryonic stem cell fates.
Milk and Cardiomyocyte Maturation – Maternal milk provides an essential signal that triggers the maturation of heart metabolism after birth.
Photo Reference: Courtesy of Dr. Insoo Hyun
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Guest:Dr. Aileen Anderson is the Director of the Sue and Bill Gross Stem Cell Research Center at the University of California, Irvine. Her lab investigates the role of inflammatory mechanisms in degeneration and regeneration in the injured central nervous system. She talks about cell therapy for spinal cord injury and how academic labs can collaborate with companies to move toward the clinic. She also discusses biomaterials to support axon regeneration.
Featured Products and Resources:* ISSCR 2023 is almost here! * Explore STEMCELL Technologies’ collection of technical videos and webinars on neurological disease modeling.
The Stem Cell Science Round UpHypoimmune iPSCs in Non-Human Primates – Scientists validated a genetic method to block immune rejection of allogeneic cells in monkeys.
Digital Retinal Organoids – A multimodal atlas of retinal organoid development shows spatial interactions over time.
Skin Vascular Maturation – Researchers tracked neonatal endothelial cells to study how vasculature matures and maintains homeostasis in live mice.
Bovine Blastoids – Scientists generated bovine blastocyst-like structures by assembling bovine trophoblast stem cells and expanded potential stem cells.
Photo Reference: Courtesy of Dr. Aileen Anderson
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Guest:Dr. Shannon McKinney-Freeman is a Principal Investigator and Member at St. Jude Children’s Research Hospital. Her lab focuses on the fundamental biology of hematopoietic stem cells (HSCs). She talks about the role of HSCs in sickle cell disease and the state of HSC transplantation research. She also discusses her work on hematopoietic progenitor expansion.
Featured Products and Resources:* Attend ISSCR 2023 in Boston! * Find educational resources to help you further your research on hematopoiesis and hematological malignancies.
The Stem Cell Science Round UpDe-Differentiation to Prevent Grey Hair – Scientists identified a new model whereby dedifferentiation is integral to homeostatic stem cell maintenance.
Seeing Stem Cell Variants – Researchers used single-cell cloning technologies to generate libraries of basal stem cells from idiopathic pulmonary fibrosis and control lungs.
How Exercise Rejuvenates Stem Cells – Exercise increases Osteopontin expression in muscle and improves muscle regeneration.
Distal Memory in Wound Healing – Cell adaptation resulting from localized tissue damage has a wide spatial impact.
Photo Reference: Courtesy of Dr. Shannon McKinney-Freeman
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Guest:Dr. Sergiu Pașca is the Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences at Stanford University and the Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program. His lab has pioneered and applied neural organoid and assembloid technologies to make discoveries in fundamental and clinical neuroscience. He talks about the response to his viral TED Talk and the importance of names for nervous system models. He also discusses CRISPR screening in assembloids to study autism, transplanting cortical organoids into rats, and biocompatible polymers for neural organoids.
Featured Products and Resources:* Register for ISSCR 2023! * Submit your best cell image to the #StemCellfie contest.
The Stem Cell Science Round UpMonkey Blastoids – Scientists generated monkey blastoids from ESCs and transferred them into surrogates to trigger pregnancies.
Clonal Hematopoiesis and Chronic Liver Disease – Researchers used whole-exome sequencing data to study the association between clonal hematopoiesis of indeterminate potential and chronic liver disease.
Cardiomyocyte Cell Therapy – Gene editing prevents arrhythmias from cell-based therapy for myocardial infarction.
Islet Transplantation Without Immunosuppression – Scientists used CRISPR to edit primary human pancreatic islet cells, making them immune-evasive.
Photo Reference: Courtesy of Dr. Sergiu Pașca
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Guest:Dr. Stylianos Lefkopoulos is an Associate Editor of Nature Cell Biology. He talks about a day in the life of an editor and what he looks for in a manuscript. He also discusses the role of preprints in publishing and promoting diversity in STEM.
Featured Products and Resources:* Register for ISSCR 2023, taking place in Boston June 14-17. * Submit your best cell image to the #StemCellfie contest!
The Stem Cell Science Round UpChemical Reprogramming – Researchers developed a reproducible and efficient protocol to generate human chemically induced pluripotent stem cells.
Base Editing to Treat SCID – T cell generation was restored through adenine base editing in cell, organoid, and mouse models of CD3δ severe combined immunodeficiency (SCID).
Trophoplast Differentiation – Scientists generated a single-cell atlas of the entire maternal–fetal interface.
Single-Cell Transcriptomics of Human Embryos During Organogenesis – Researchers used single-cell and spatial transcriptomics to provide a global view of human embryonic cell-type specification.
Photo Reference: Courtesy of Dr. Stylianos Lefkopoulos
Guest:Dr. Noriaki Ono is an Associate Professor at the University of Texas Health Center at Houston. His research focuses on bone development and regeneration. He talks about in vivo lineage tracing techniques and how early perichondrial cells contribute to developing bones. He also discusses the art and science of dentistry, mentorship, and moving his lab across the country.
Featured Products and Resources:* Register for ISSCR 2023, taking place in Boston June 14-17. * Expand, maintain, and differentiate skeletal muscle progenitor cells.
The Stem Cell Science Round UpMaking Eggs from Male Mice – Researchers differentiated male iPSCs into oocytes, which gave rise to offspring after fertilization.
Liver Regeneration – Transitional liver progenitor cells are bipotent and differentiate into hepatocytes during regeneration.
A Key Factor for SARS-CoV-2 Infection – Scientists used a multi-organoid platform to identify the role of circadian-clock regulation in SARS-CoV-2 infection.
Pancreatic Cancer Organoids – Transcriptomic analysis of pancreatic cancer organoids suggested that non-neoplastic cells in the tumor microenvironment can modulate tumor cell invasion.
Photo Reference: Courtesy of Dr. Noriaki Ono
Guest:Dr. Alysson Muotri is a Professor at the School of Medicine, University of California in San Diego. His research focuses on modeling neurological diseases, such as Autism Spectrum Disorders, using human induced pluripotent stem cells. His lab has developed several techniques to culture human neurons and glia for basic research and drug-screening platforms. Most recently he and his group published a paper reporting the first cellular model of anorexia nervosa, reprogramming induced pluripotent stem cells derived from adolescent females with the eating disorder.
Featured Resource: CloneR Defined Supplement for Single-Cell Cloning of Human ES and iPS Cells
Resources and LinksHow a Budget Squeeze Can Lead to Sloppy Science and Even Cheating – A funding crunch for scientific research is creating incentives for scientists to cut corners and even occasionally to cheat.
New Tech Harvests Drinking Water from (Relatively) Dry Air Using Only Sunlight – A new device the size of a coffee mug can generate drinkable water from desert air using nothing but sunlight.
New CRISPR Tool Can Detect Tiny Amounts of Viruses – The new exquisitely sensitive and specific CRISPR tool promises to help detect diseases that other diagnostics miss, and it’s simple and cheap to use.
Allen Cell Explorer – Graham Johnson and the Allen Institute for Cell Science’s team of nearly 50 cell biologists, microscopy specialists, and computer programmers revealed what they’ve been working on the past two years: the Allen Cell Explorer, which is the largest public collection of human cells ever visualized in 3D, that serves as fuel for the project’s engine: the first-ever deep learning model to predict how cells are organized.
The EPS Cell, a New Stem Cell – Salk Institute and Chinese researchers said they have created a new kind of stem cell called an extended pluripotent stem cell or EPS cell, one that is more versatile than any other grown in the lab and can grow into any tissue in the body.
Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers – Researchers used comparison of induced pluripotent stem cell-derived endothelial cells from three families with unaffected mutation carriers, familial pulmonary arterial hypertension patients, and gender-matched controls to investigate this variation.
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity – This article reveals that ∼50% of genome-wide expression variability is explained by variation across individuals and identified a set of expression quantitative trait loci that contribute to this variation.
Reprogramming the Brain’s Own Cells for Parkinson’s Treatment – A study from the Karolinska Institute in Stockholm shows it is possible to coax the brain’s own astrocytes—cells that typically support and nurture neurons—into producing a new generation of dopamine neurons.
Photo Reference: Courtesy of Dr. Alysson Muotri
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Guest:Dr. Ryan Conder is the Director of Epithelial and Organoid Systems at STEMCELL Technologies. He talks about the next phase in organoid research and what questions organoids can help answer. He also discusses his experience doing a postdoc in Vienna, and Vancouver as a growing biotech hub.
Featured Products and Resources:* Register for ISSCR 2023, taking place in Boston June 14-17. * Download an e-book covering the evolution of organoids, from their development to updated applications and future outlooks.
The Stem Cell Science Round UpTransplanting Islets into the Omentum – Researchers transplanted islets to a bioengineered omental pouch in non-human primates.
Bat iPSCs and Viruses – Scientists created iPSCs from two species of bats and identified a high number of endogenous viral sequences.
Regeneration in Duchenne Muscular Dystrophy – Forskolin reduced senescence of skeletal muscle stem cells and improved muscle function in a rat model of Duchenne muscular dystrophy.
Deer Antler Regeneration – Scientists used single-cell transcriptomics to construct a cell atlas of antler regeneration.
Photo Reference: Courtesy of STEMCELL Technologies
Guests:Keith Alm is the CEO, Dr. Haifan Lin is the President, and Dr. David Scadden is 2023 Annual Meeting Program Chair of the ISSCR. They talk about the upcoming annual meeting being held this year in Boston, a biotech hub with a vibrant stem cell research community. They discuss the highlights of this year’s program including speakers, award winners, and more. They also discuss making this year’s meeting more accessible to trainees and researchers around the world.
Featured Products and Resources:* Register for ISSCR 2023, taking place in Boston June 14-17. * STEMCELL Technologies is hiring!
The Stem Cell Science Round UpIntegrating Organoids into the Rat Visual Cortex – Researchers integrated human brain organoids into the injured visual cortices of adult rats.
Mitochondria Metabolism and Neuronal Development – Metabolic rates in mitochondria help set the speed of neuronal development.
Neural Progenitor Cell Villages – Researchers analyzed neural progenitor cells to identify genes associated with viral susceptibility.
Activating Protein Clearance in ALS – PIKFYVE inhibition clears aggregation-prone proteins via exocytosis in ALS animal models and patient-derived motor neurons.
A Therapeutic Target for ALS – SYF2 suppression alleviates disease in a diverse collection of iPSC models of ALS.
Photo Reference: Courtesy of Keith Alm, Dr. Haifan Lin, and Dr. David Scadden
Guest:Dr. Lorenz Studer is the Director of the Center for Stem Cell Biology at Memorial Sloan Kettering Cancer Institute. His lab exploits recent advances in stem cell biology to develop new therapies for degenerative diseases and cancer. Their projects involve directing the fate and age of hPSCs, modeling diseases, and developing cell therapies. He talks about his journey into the stem cell field and co-founding BlueRock Therapeutics. He also discusses the challenges of developing cell therapies at scale, strategies to target cognition loss in Parkinson’s disease, and combining basic and translational research.
Featured Products and Resources:* Register for ISSCR 2023, taking place in Boston June 14-17. * Explore ways to assess your human pluripotent stem cells and essential quality attributes.
The Stem Cell Science Round UpiPSC Organization – Researchers mapped the 3D cellular organization of more than 200,000 live cells.
Modeling the Gut–Immune Interface – Scientists transplanted human intestinal organoids into humanized mice to study human intestinal–immune crosstalk during development.
Deep Learning to Predict Arrhythmia Risk – Deep learning can identify in vitro arrhythmic features that correlate with clinical arrhythmia.
Gastric Isthmus Stem Cells – Researchers developed a monolayer 2D culture system to study the isthmus and uncovered a role for Sox2 in enterochromaffin cells.
Photo Reference: Courtesy of Dr. Lorenz Studer
Guest:Dr. Boyang Zhang is an Assistant Professor of Chemical Engineering at McMaster University. His lab uses advanced biofabrication techniques to build human micro-tissue models for predictive drug discovery and to construct functional macro-tissues for tissue regeneration in patients. He talks about building microfluidic devices for biological applications and using machine learning to study organoid morphology. He also talks about his team’s high-throughput system for vascularizing tissue spheroids and his experience starting a company to commercialize this technology.
Featured Products and Resources:* Register for ISSCR 2023, taking place in Boston June 14-17. * Explore resources to support your organoid culture.
The Stem Cell Science Round UpThe Segmentation Clock and Wavefront in Somitogenesis – Researchers used 3D hPSC culture systems to study human somitogenesis in vitro.
Gene Therapy for Cardiac Regeneration – Tissue-regeneration enhancer elements isolated from zebrafish deliver YAP to boost heart tissue regeneration in mice.
Aging Markers in Children Conceived Through Assisted Reproduction – Children born following blastocyst-stage embryo transfer had shorter leukocyte telomeres than those conceived spontaneously.
Engineering Cell Adhesion Molecules – Scientists engineered cells containing customized adhesion molecules that bound with specific partner cells in predictable ways to form complex multicellular ensembles.
Photo Reference: Courtesy of Dr. Boyang Zhang
Guests:In this special episode, Daylon and Arun chat with Drs. Jason Goldsmith and Brenda Raud, the hosts of The Immunology Podcast. Recorded in-person and led by Dr. Nicole Quinn from STEMCELL Technologies, the four hosts discuss the impact that podcasting has had on their careers and how it can make science and scientists more accessible. They also talk about the future of science communication and advice for young scientists pursuing careers in academia and industry.
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Guest:Dr. Clive Svendsen is the Executive Director of the Regenerative Medicine Institute at Cedars-Sinai. His lab uses stem cells to develop models and treatments for neurodegenerative diseases. He talks about using stem cells to model spinal muscular atrophy and the blood-brain barrier, and his cell-gene therapy trial for ALS.
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The Stem Cell Science Round UpEmbryonic Angiogenesis – Monocytes deposit migrasomes to promote angiogenesis in chick embryos.
Stem Cell Crosstalk with the Microenvironment – Ras drives malignancy in squamous cell carcinoma through aberrant crosstalk between cancer stem cells and their microenvironment.
The Extracellular Matrix and Naive Pluripotency – A three-dimensional extracellular matrix-rich environment preserves long-term feeder-free naive hiPSC self-renewal.
Cell Senescence in Alzheimer’s Disease – Alzheimer’s disease brains have high proportions of neurons that express senescence markers.
Photo Reference: Courtesy of Dr. Clive Svendsen
Dr. Shuibing Chen is the Kilts Family Professor of Surgery at Weill Cornell Medicine. Her lab uses hiPSCs and ESCs for disease modeling and drug screening, with a focus on diabetes and infectious diseases such as Zika and SARS-CoV-2. She talks about her recent genome-wide association study in a dish, the role of philanthropic funding in stem cell research, and the role of industry partnerships in translational research.
Guest: Dr. Paola Arlotta is the Golub Family Professor of Stem Cell and Regenerative Biology at Harvard University. She is interested in understanding the molecular laws that govern the birth, differentiation, and assembly of the…
Guest: Dr. Jacob Hanna is an Associate Professor at the Weizmann Institute of Science. His lab investigates cellular reprogramming and embryogenesis. He talks about the challenges of growing synthetic embryo models in a roller culture…
Dr. Stefan Irion is the Senior Vice President of Research at BlueRock Therapeutics, a leading engineered cell therapy company with a mission to develop regenerative medicines for intractable diseases. He talks about the company's Parkinson's disease trial and the challenges of genetically manipulating stem cells. He also discusses his journey from physician to scientist and his personal connection to Parkinson's disease.
Dr. Jun Wu is an Assistant Professor at the University of Texas Southwestern. The Wu lab uses interspecies chimeras to study fundamental biology: conserved and divergent developmental programs, determination of body and organ size, species barriers, and cancer resistance. They are also working to develop new applications for regenerative medicine. He talks about developmental compatibility between species, and the similarities and differences between blastoid models and blastocyts. He also discusses the challenges of growing human cells in animals, and human-monkey chimeric embryos.
Dr. Edward Grow is an Assistant Professor at the University of Texas, Southwestern. His lab studies reproductive biology, specifically the development of the egg and subsequently the fertilized embryo. He talks about regulating totipotency in ESCs, retroviral reactivation, and ex vivo culturing of follicles and oocytes.
Dr. Prisca Liberali is Senior Group Leader at the Friedrich Miescher Institute for Biomedical Research and an Assistant Professor at the University of Basel. Her research aims to understand the collective properties of organoid systems and their patterns, including how these systems allow systematic perturbation by established methods for modulating gene expression. She studies self-organization, symmetry breaking, intestinal organoid development, gastruloids, and mechanosensing mechanisms.
Drs. Tenneille Ludwig, Peter Andrews, and Madeline Lancaster are members of the ISSCR Standards Initiative for Pluripotent Stem Cell Research. They discuss the need for basic and preclinical standards to ensure rigor and reproducibility in stem cell research. They also talk about standards for pluripotency and model systems, and the initiative's international focus.
Dr. Jackie Damen is a currently a Principal Scientist in Scientific Support for Hematology at STEMCELL Technologies, and was previously the Director of Contract Assay Services. She talks about the company's culture and growth, and how in her role, she teaches scientists and helps them conduct their experiments. She also discusses systems for drug screening and discovery, opportunities in industry, and her affinity for microscopy and photography.
Dr. Marian Hettiaratchi is an Assistant Professor at the Knight Campus at the University of Oregon. Her research focuses on affinity-based biomaterials to promote tissue and bone repair. She talks about the delivery vehicles for these biomaterials, and her recent work on heparin-mediated delivery of BMP-2 to promote bone regeneration.
Guest: Dr. Lydia Finley is an Assistant Member of the Cell Biology Program at Memorial Sloan Kettering Cancer Center. The Finley lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and…
In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco. We spoke with delegates to get their impressions of the meeting. They discussed the most memorable research presented and shared their thoughts on the challenges facing the stem cell field.
In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the final of four special episodes from the meeting.
In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of four special episodes from the meeting.
In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the second of four special episodes from the meeting.
In June 2022, we attended the International Society for Stem Cell Research (ISSCR) annual meeting in San Francisco, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the first of four special episodes from the meeting.
Dr. Michael Levin is the Director of the Allen Discovery Center and a Distinguished Professor of Biology at Tufts University. He is a cognitive biologist who utilizes model systems such as Xenopus to answer fundamental questions in developmental biology. He talks about regenerating frog legs, using bioelectricity to direct development, and the potential applications of xenobots.
Dr. Steven Stice is the DW Brooks Distinguished Professor and Director of the Regenerative Bioscience Center at the University of Georgia, and the Co-Founder and Chief Scientific Officer of ArunA Biomedical. He talks about his early work cloning rabbits and reprogramming blastomeres. He also discusses using exosomes to treat neurological diseases, helping trainees move into industry, and preserving endangered species.
Dr. Amritha Jaishankar is the Executive Director of the Maryland Stem Cell Research Fund (MSCRF). She is a scientist by training who has devoted her career to developing cures for debilitating and life-threatening conditions of our time and to advancing this field, through various roles in federal, university, and industry settings. She talks about the history of the MSCRF, its programs to promote the commercialization of stem cell-based technologies, and its role in the Maryland stem cell research ecosystem.
Dr. Ophir Klein is the inaugural Executive Director of Cedars-Sinai Guerin Children's and the David and Meredith Kaplan Distinguished Chair in Children's Health. He discusses his work on intestinal epithelium regeneration, which he will present at the “Tissue Fibrosis and Repair: Mechanism, Human Disease, and Therapies” Keystone Symposium taking place from June 12-16th in Keystone, Colorado. He also talks about mechanisms of tooth development, analyzing three-dimensional facial images to diagnose genetic syndromes, and how parasitic infections affect the intestinal stem cell niche.
Dr. Ophir Klein is the inaugural Executive Director of Cedars-Sinai Guerin Children's and the David and Meredith Kaplan Distinguished Chair in Children's Health. He discusses his work on intestinal epithelium regeneration, which he will present at the “Tissue Fibrosis and Repair: Mechanism, Human Disease, and Therapies” Keystone Symposium taking place from June 12-16th in Keystone, Colorado. He also talks about mechanisms of tooth development, analyzing three-dimensional facial images to diagnose genetic syndromes, and how parasitic infections affect the intestinal stem cell niche.
Dr. David Hay is the Chair of Tissue Engineering at the University of Edinburgh, where his group is defining novel ways to produce liver tissue from PSCs. They use in vitro derived tissue to better model human liver physiology and to develop supportive cell based therapies for disease. Dr. Hay also founded Stimuliver, a company that is developing a disruptive liver implant to treat critically failing liver function in humans. He talks about hepatocyte differentiation, liver disease modeling, and automating the production of cell therapies.
Dr. David Hay is the Chair of Tissue Engineering at the University of Edinburgh, where his group is defining novel ways to produce liver tissue from PSCs. They use in vitro derived tissue to better model human liver physiology and to develop supportive cell based therapies for disease. Dr. Hay also founded Stimuliver, a company that is developing a disruptive liver implant to treat critically failing liver function in humans. He talks about hepatocyte differentiation, liver disease modeling, and automating the production of cell therapies.
Dr. Agnete Kirkeby is an Associate Professor at the University of Copenhagen and a Group Leader at Lund University. The Kirkeby group studies the factors involved in human neural subtype specification in order to enable production of specific neurons for understanding and treating neurological diseases. They apply advanced human stem cells models to understand how hundreds of human neuronal subtypes are formed during embryo development. She talks about moving stem cell therapies for Parkinson's disease from animal models to clinical trials, modeling neural tube development, and developing treatments for narcolepsy.
Dr. Agnete Kirkeby is an Associate Professor at the University of Copenhagen and a Group Leader at Lund University. The Kirkeby group studies the factors involved in human neural subtype specification in order to enable production of specific neurons for understanding and treating neurological diseases. They apply advanced human stem cells models to understand how hundreds of human neuronal subtypes are formed during embryo development. She talks about moving stem cell therapies for Parkinson's disease from animal models to clinical trials, modeling neural tube development, and developing treatments for narcolepsy.
Dr. Melissa Little is the President, Keith Alm is the CEO, and Dr. Amander Clark is the Vice President of the International Society for Stem Cell Research (ISSCR). They discuss what they're looking forward to at the upcoming ISSCR 2022 meeting, and the future of the organization and the stem cell research community.
Dr. Melissa Little is the President, Keith Alm is the CEO, and Dr. Amander Clark is the Vice President of the International Society for Stem Cell Research (ISSCR). They discuss what they're looking forward to at the upcoming ISSCR 2022 meeting, and the future of the organization and the stem cell research community.
Dr. Kelly McNagny is a Professor of Medical Genetics and Biomedical Engineering at the University of British Columbia. His research program is focused on hematopoietic stem cell biology, specifically in understanding the signaling networks that regulate stem cell differentiation and how these cells interact with their microenvironment. He talks about how hematopoietic stem cell differentiation is related to chronic inflammatory disorders, targeting glycosylation in solid tumors, and his international career path.
Dr. Kelly McNagny is a Professor of Medical Genetics and Biomedical Engineering at the University of British Columbia. His research program is focused on hematopoietic stem cell biology, specifically in understanding the signaling networks that regulate stem cell differentiation and how these cells interact with their microenvironment. He talks about how hematopoietic stem cell differentiation is related to chronic inflammatory disorders, targeting glycosylation in solid tumors, and his international career path.
Dr. Mingxia Gu is an Assistant Professor of Pediatrics at Cincinnati Children's Hospital. Her lab's goal is to develop novel therapies for the regeneration of the heart, lung, and vasculature in patients with congenital cardiac and pulmonary defects. She talks about developing lung organoids to study COVID-19, how multi-lineage organoids can mimic human tissues, and her lab's motto to "move fast and break things."
Dr. Mingxia Gu is an Assistant Professor of Pediatrics at Cincinnati Children's Hospital. Her lab's goal is to develop novel therapies for the regeneration of the heart, lung, and vasculature in patients with congenital cardiac and pulmonary defects. She talks about developing lung organoids to study COVID-19, how multi-lineage organoids can mimic human tissues, and her lab's motto to "move fast and break things."
Dr. Alejo Rodriguez-Fraticelli is a Group Leader at the Institute for Research in Biomedicine in Barcelona, where his team studies stem cell memory and epigenetics in hematopoiesis, immunity, and leukemia. He talks about setting up a new lab as a "playground for scientists," how cancer is the "evil twin" of regeneration, and advanced methods for lineage tracing.
Dr. Alejo Rodriguez-Fraticelli is a Group Leader at the Institute for Research in Biomedicine in Barcelona, where his team studies stem cell memory and epigenetics in hematopoiesis, immunity, and leukemia. He talks about setting up a new lab as a "playground for scientists," how cancer is the "evil twin" of regeneration, and advanced methods for lineage tracing.
Dr. Nazish Sayed is an Assistant Professor of Surgery at the Stanford Cardiovascular Institute. His lab is focused on developing new technologies that drive innovation in regenerative medicine, disease modeling, and drug testing in vascular biology. He talks about developing an inflammatory aging clock, using iPSC-derived endothelial cells to run a clinical trial in a dish, and his experience as a cancer patient.
Dr. Nazish Sayed is an Assistant Professor of Surgery at the Stanford Cardiovascular Institute. His lab is focused on developing new technologies that drive innovation in regenerative medicine, disease modeling, and drug testing in vascular biology. He talks about developing an inflammatory aging clock, using iPSC-derived endothelial cells to run a clinical trial in a dish, and his experience as a cancer patient.
Dr. Ru Gunawardane is the Executive Director at the Allen Institute for Cell Science. She leads a group of researchers creating a collection of high-quality gene edited stem cell lines to study cell organization and activities through live cell imaging. Dr. Katylyn Gerbin is a Scientist at the Allen Institute, whose work focuses on implementing cardiac differentiation methods and developing the cardiomyocyte pipeline using gene-edited hiPSCs. They discuss the Institute's mission to understand the fundamentals of how cells work, how they generate their gene-edited stem cell lines, and their recent work tracking cell states in hiPSC-derived cardiomyocytes.
Dr. Ru Gunawardane is the Executive Director at the Allen Institute for Cell Science. She leads a group of researchers creating a collection of high-quality gene edited stem cell lines to study cell organization and activities through live cell imaging. Dr. Katylyn Gerbin is a Scientist at the Allen Institute, whose work focuses on implementing cardiac differentiation methods and developing the cardiomyocyte pipeline using gene-edited hiPSCs. They discuss the Institute's mission to understand the fundamentals of how cells work, how they generate their gene-edited stem cell lines, and their recent work tracking cell states in hiPSC-derived cardiomyocytes.
Dr. Ilyas Singeç is the Director of the Stem Cell Translation Laboratory at the National Center for Advancing Translational Sciences, where he leads a group of scientists working to address efficiency, reproducibility, scalability, and other roadblocks in the translation of iPSCs into therapies. He discusses the standardization of stem cell differentiation, high-throughput cell culture, personalized medicine, and the potential for biomanufacturing in space.
Dr. Ilyas Singeç is the Director of the Stem Cell Translation Laboratory at the National Center for Advancing Translational Sciences, where he leads a group of scientists working to address efficiency, reproducibility, scalability, and other roadblocks in the translation of iPSCs into therapies. He discusses the standardization of stem cell differentiation, high-throughput cell culture, personalized medicine, and the potential for biomanufacturing in space.
Dr. Sara Wickström is the Sigrid Juselius Professor of Cell and Developmental Biology at the University of Helsinki, and was recently appointed as the new Director of Cell and Tissue Dynamics at the Max Planck Institute for Molecular Biomedicine. Her research focuses on how mechanical forces act in collaboration with cellular signals to influence cell fate and position. She discusses her work on mechanotransduction and its applications for cell culture and organ engineering, as well as her research on the hair follicle stem cell niche. She also talks about running an interdisciplinary lab, and what could make academia a more attractive career path.
Dr. Christine Mummery is a Professor of Developmental Biology at the Leiden University Medical Center and the former President of the International Society for Stem Cell Research. She pioneered studies on cardiomyocytes from human embryonic stem cells and was among the first to inject them in mouse hearts after myocardial infarction. She talks about her recent research developing multi-lineage cardiac model systems like microtissues and organ-chips.
Dr. Kate Rubins is a NASA astronaut and microbiologist. She has completed two expeditions to the International Space Station and spent 300 days in space. She became the first person to sequence DNA in space in 2016, and grew cardiomyocytes in cell culture (in collaboration with Arun in Joseph Wu’s lab at Stanford) while in orbit. She has a PhD in Cancer Biology from Stanford University and studied viral diseases as a Fellow/Principal Investigator at the Whitehead Institute.
Dr. Maria Millan is the President and CEO of the California Institute for Regenerative Medicine, which aims to accelerate stem cell treatments for patients with unmet medical needs. Dr. Millan is a physician-scientist who has devoted her career to treating and developing innovative solutions for children and adults with debilitating and life-threatening conditions, both as a transplant surgeon and in the private sector.
Dr. Paul Knoepfler is a Professor in the Department of Cell Biology and Human Anatomy, the Genome Center, and the Comprehensive Cancer Center at the University of California, Davis. His lab is interested in the epigenetics of stem cells and cancer, and uses cutting-edge molecular, cellular, and developmental biology methods as well as genomic and gene editing technologies to answer key questions in these areas of research.
Dr. Jennifer Trowbridge is an Associate Professor at the Jackson Laboratory and an Adjunct Professor at Tufts University. Her lab studies genetics and epigenetics in hematopoietic stem cell biology and leukemia. Their long-term goal is to identify new intervention strategies to extend the “healthspan” of HSCs by maintaining their robust regeneration capacity into older age and reducing risk of development of blood cancers.
In this special episode of the Stem Cell Podcast, we speak with three postdocs from different parts of the world about their research in and outside of the lab. Drs. Bria Macklin, Matthew Sinton, and Leili Rohani discuss their research on vascularization, immunometabolism, and cardiac tissue engineering, respectively, as well as their long-term career goals.
Dr. Connie Eaves is a Distinguished Scientist at the Terry Fox Laboratory at the British Columbia Cancer Agency and a Professor of Medical Genetics at the University of British Columbia. Her research focuses on leukemia and breast cancer and the normal tissues in which these diseases originate. Her pioneering research in basic blood stem cell biology led to a breakthrough in treatment for leukemia.
Dr. Ken Poss is the James B. Duke Professor of Cell Biology and Head of the Duke Regeneration Center at Duke University. His lab investigates the initial morphogenesis and injury-induced regeneration of several tissues in zebrafish. He is also President of the newly-founded International Society for Regenerative Biology.
Dr. Anthony Atala is the Founding Director of the Wake Forest Institute for Regenerative Medicine and the Chair of Urology at the Wake Forest School of Medicine. His team developed the first lab-grown organ to be implanted into a human and he currently oversees a team of over 400 researchers who are working to develop cell therapies and engineer replacement organs and tissues.
Bernie Siegel is an attorney and policy expert relating to stem cell research, regenerative medicine, and human cloning. He is the Executive Director of the Regenerative Medicine Foundation and the Founder of the World Stem Cell Summit.
Dr. Aparna Bhaduri is an Assistant Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her lab studies how the human brain is created, with billions of cells spanning hundreds or thousands of cell types. They also explore how the cell building blocks of development can reappear later in life in brain cancers such as glioblastoma.
Dr. Nicolas Rivron is a Group Leader at IMBA. The Rivron group recreates embryonic development using mammalian stem cells in a dish to better understand the encoded principles of self-organization. They observe both blastocysts and blastoids to study how self-organization contributes to multicellular patterning and cellular decision making.
In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting, featuring Dr. Sheila Charli from Cell Stem Cell.
Dr. Shahin Rafii is a Professor of Reproductive Medicine and the Arthur B. Belfer Professor in Genetic Medicine at Weill Cornell Medical College, as well as Director of the Ansary Stem Cell Institute. His research focuses on stem cell biology and angiogenesis. We discuss his research and thoughts on the meeting.
In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting featuring Dr. Madeline Lancaster from the Medical Research Council (MRC) Laboratory of Molecular Biology, who was honored with the Dr. Susan Lim Award for Outstanding Young Investigator Lecture at the meeting.
In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting featuring Dr. Chuck Murry from the University of Washington, who presented during the Presidential Symposium: What's in a Germ Layer session on the first day of the meeting.
Dr. Stephen Sullivan is the Program Manager and International Liaison Officer at the Global Alliance for iPSC Therapies (GAiT), an international initiative to support the implementation and clinical application of therapies derived from pluripotent stem cells to the benefit of patients globally.
Dr. Emma Hammarlund is a Principal Investigator in the Division of Translational Cancer Research at Lund University Cancer Center and the Lund Stem Cell Center. Her lab investigates how the rise of animals on Earth relates to the evolution of stemness control.
Dr. Themasap Khan is the Vice President at Civilization Ventures, a venture capital firm that invests in genomics, diagnostics, digital health, AI, and personalized and regenerative medicine. He leads the firm’s scientific due diligence and academic outreach programs. Dr. Khan earned his in PhD in stem cell biology and regenerative medicine in Dr. Sergiu Pasca’s lab at Stanford, where his research focused on genome engineering, cerebellar organoid models, and live imaging to elucidate biological mechanisms underlying neuropsychiatric disorders.
Dr. Johan Jakobsson is a Professor of Molecular Neurogenetics at the Lund Stem Cell Center. His research focuses on epigenetic mechanisms of the brain, including the role of microRNAs, long non-coding RNAs, and endogenous retroelements in neural stem cells and neurons.
Dr. Marinna Madrid is co-founder of Cellino, an early-stage biotechnology company seeking to make personalized, autologous cell therapies viable at large scale for the first time.
Dr. Brenda Raud is a postdoctoral researcher at the Netherlands Cancer Institute and Dr. Jason Goldsmith is the Director of Donor Medical Sciences at Seres Therapeutics. In addition to their work as immunology researchers, Brenda and Jason are also hosts of the new Immunology Podcast, a sister podcast to the Stem Cell Podcast.
Guest: Dr. Krishana Sahu is an Associate Professor in the Department of Biomedical Engineering at the University of Wisconsin-Madison. His lab utilizes quantitative and bioengineering methods including genome editing, biomanufacturing, and disease modeling to advance…
Dr. Kelly Shepard is the Associate Director of Discovery and Translation at the California Institute for Regenerative Medicine (CIRM). CIRM was created by the voters of California in 2004. The agency funds stem cell research at institutions and companies throughout California with the goal of accelerating treatments to patients with unmet medical needs.
Dr. Willy Lensch is Strategic Advisor to the Dean at Harvard Medical School. Previously Executive Director of the Harvard Department of Stem Cell and Regenerative Biology, his experience in research, education, administration, science policy, intellectual property, science consulting, and outreach have combined to support and advance stem cell science and discovery at Harvard.
Dr. Sean Wu is an Associate Professor of Medicine at the Stanford School of Medicine. The Wu lab seeks to identify mechanisms responsible for human congenital heart disease, and uses mouse models and stem cells to study cardiovascular developmental biology, and to engineer cardiac tissue.
Dr. Jürgen Knoblich is Scientific Director of the Institute of Molecular Biotechnology at the Austrian Academy of Sciences. The Knoblich lab is known for the development of an organoid model of early brain development, and is currently using iPSCs and cerebral organoids to investigate inter-brain region interactions, neurodevelopmental disorders, and neuronal connections and functions.
Dr. Vivian Li is Group Leader of the Stem Cell and Cancer Biology Laboratory at the Francis Crick Institute. The Li lab investigates how Wnt signalling controls stem cells in the healthy gut and during colorectal cancer development. The lab also aims to engineer function intestinal constructs using patient-derived intestinal organoids.
Dr. Samira Musah is an Assistant Professor in the Department of Biomedical Engineering at Duke University. The Musah Lab applyies stem cell biology to engineer functional models of the human kidney and brain, with the goal of developing novel therapeutic modalities for human kidney diseases.
Dr. Christopher Thomas Scott is the Dalton Tomlin Professor of Medical Ethics and Health Policy at Baylor College of Medicine. Scott is also emeritus faculty of the Stanford University Center for Biomedical Ethics. His research centers on the ethical, legal, and social implications of emerging biotechnologies.
Dr. Matthias Lutolf is a Professor and Principal Investigator of the Laboratory of Stem Cell Bioengineering at the École Polytechnique Fédérale de Lausanne. His lab uses cutting-edge bioengineering strategies for guiding stem-cell-based development for the assembly of next-generation organoids with improved reproducibility and physiological relevance.
In this special episode of the Stem Cell Podcast, we speak with three PhD students — Nathasia Mudiwa Muwanigwa, Sarthak Sinha, and Naveed Tavakol — about their research into brain organoids, organ-on-chip systems, and regeneration in different mammals.
Dr. Miki Ebisuya is a Group Leader at the European Molecular Biology Laboratory in Barcelona. Her lab reconstitutes developmental mechanisms by making artificial gene circuits, and studies interspecies differences by comparing organoids of different animals.
Dr. Tom Cheung is the S H Ho Associate Professor of Life Science at the Hong Kong University of Science and Technology. His lab investigates the molecular pathways that control muscle stem cell quiescence and stem cell-mediated tissue regeneration.
Dr. Ludovic Vallier is a Professor of Regenerative Medicine at the Cambridge Stem Cell Institute and Director of the NIHR Cambridge Biomedical Centre hiPSC core facility. His lab studies the basic mechanisms controlling differentiation of pluripotent cells into endoderm progenitors from which the pancreas, lung, gut and liver originate.
Dr. Valerie Horsley is an Associate Professor of Molecular, Cellular, and Developmental Biology, and Associate Professor of Dermatology at Yale University. Her lab studies how adult stem cells within epithelial tissues maintain tissue homeostasis, wound healing and can contribute to cancer formation.
Dr. Henner Farin is a Young Investigator in the German Cancer Consortium, and a Junior Research Group Leader at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy. His group uses organoids to study cell signaling in intestinal stem cells and colorectal cancer.
Dr. Sergiu Pașca is an Assistant Professor of Psychiatry and Behavioral Sciences at Stanford University, and the Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program. His team has developed methods for generating human cerebral organoids, and uses them to study the programs underlying brain development, assembly and dysfunction.
Dr. Martin Pera is a Principal Investigator at the Jackson Laboratories and Editor-in-Chief of the ISSCR's journal Stem Cell Reports. His lab studies the regulation of self-renewal and pluripotency, heterogeneity in pluripotent stem cell populations, and neural specification of pluripotent stem cells.
Dr. Dominique Bonnet is the Group Leader of the Hematopoietic Stem Cell Laboratory at the Francis Crick Institute. Her lab is interested in the extrinsic mechanisms that regulate hematopoietic stem cells, and how they can intervene in order to eradicate the leukemic stem cell.
Dr. Kristy Red-Horse is an Associate Professor of Biology at Stanford University. Her lab uses cardiovascular development as a model to study the signals that instruct cell fate and guide morphogenesis during organ formation in the mammalian embryo.
Dr. Valentina Greco is the Carolyn Slayman Professor of Genetics at Yale University. Her lab has developed novel live imaging approaches to track and manipulate stem cells in live animals, allowing them to study the complex orchestration of tissue regeneration using the skin as a model system.
Dr. Madeline Lancaster is a Group Leader at the MRC Laboratory of Molecular Biology in Cambridge, UK. The Lancaster lab has developed cerebral organoids as a model system to better understand human brain evolution, development, and neurodevelopmental disorders. She joined us to discuss her research presentated at the ISSCR 2020 conference.
Dr. Benoit Bruneau is the Director of the Gladstone Institute of Cardiovascular Disease. His lab uses mouse models and human iPSCs to investigate the transcription factor networks that regulate sets of genes critical for heart development.
Dr. Karl Koehler is an Assistant Professor of Otolaryngology at Harvard Medical School. His lab focuses on using human organoid systems as a platform to model congenital diseases and develop regenerative medicine therapies for the inner ear and various craniofacial tissues.
Dr. Freda Miller, from the Hospital for Sick Children Research Institute and the University of Toronto, studies the cellular mechanisms that regulate development of the mammalian nervous system, with a particular interest in stem cells and trophic factors.
Dr. Hans Clevers from the Hubrecht Institute for Developmental Biology and Stem Cell Research is a pioneer in the field, studying the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells.
Dr. Sheila Chari is the Editor-in-Chief at the journal Cell Stem Cell, and Executive Editor at Cell Press. As the Editor-in-Chief, Dr. Chari’s primary responsibilities are knowing and publishing the top stem cell discoveries, driving journal publishing strategy, and managing a global editorial staff.
Dr. Josef Penninger is from the University of British Columbia and the Institute for Molecular Biotechnology of the Austrian Academy of Sciences in Vienna, Austria. He was previously on the podcast to talk about his research developing human blood vessel organoids. Dr. Penninger’s team has identified a trial drug that can significantly block early stages of COVID-19 in human blood vessel and kidney organoids.
Dr. Darcy Wagner from the Lund Stem Cell Center uses a multidisciplinary approach to understand how the extracellular environment directs stem cell behavior for endogenous and exogenous lung tissue regeneration.
Dr. Deepak Srivastava is the President of the Gladstone Institutes and the International Society for Stem Cell Research, and the co-founder of Tenaya Therapeutics. His lab investigates the gene networks that guide cardiogenesis by developing models of heart disease using patient-derived iPSCs and CRISPR technology.
Dr. Jeanne Loring is a Professor Emeritus and Director of the Center for Regenerative Medicine at the Scripps Research Institute. Her lab works on a diverse range of projects using iPSCs, from developing cell replacement therapies for Parkinson’s disease, to sending neural organoids into space, and partnering with the San Diego zoo to make iPSCs from engangered species.
Dr. Joy Wu is an Associate Professor of Medicine at Stanford University, and a a board-certified endocrinologist. With both basic and translational research, her lab focuses on the mechanisms guiding the differentiation of mesenchymal stem cells, and how mesenchymal lineages support hematopoiesis in the bone marrow.
Dr. Thomas Reh is a Professor of Biological Structure at the University of Washington School of Medicine. His research is aimed at stimulating more effective regeneration in the retina to restore vision in people that have lost their sight.
Priye Iworima is a PhD student at the University of British Columbia. Her project is focused on developing and optimizing a differentiation protocol for generating insulin-producing cells derived from stem cells that could be used as a potential therapy for type 1 diabetes.
Dr. Kacey Ronaldson-Bouchard is an Associate Research Scientist at Columbia University focusing on biomedical engineering. She is also the co-founder of TARA Biosystems, which offers physiologically relevant human “heart-on-a-chip” tissue models for cardiac risk assessment and drug discovery applications.
Guest: Dr. Todd McDevitt is a Senior Investigator at the Gladstone Institutes. He is also Program Director of the University of California, San Francisco’s Bioengineering Graduate Program (joint with UC Berkeley), and a Professor at…
Dr. Nicole Quinn is the Associate Director of Scientific Communications at STEMCELL Technologies, and one of the people hard at work behind the scenes of the Stem Cell Podcast. After completing her PhD in genomics and discovering her love of communicating science, Nicole left the bench to pursue a science communications career in the biotech industry.
Guest: Dr. Camilla Forsberg is the Co-Director of the Institute for the Biology of Stem Cells, and a Professor of Biomolecular Engineering at the University of California, Santa Cruz. Her lab seeks to understand the…
Dr. Peter Zandstra is the Director of the School of Biomedical Engineering at the University of British Columbia. His lab applyies engineering design principles, computational modeling, and fundamental stem cell biology to study the mechanisms that control stem cell fate, and to develop technologies for the propagation of stem cells and their derivatives.
Dr. Celina Juliano is an Assistant Professor at the University of California, Davis. Her lab studies development and regeneration in the aquatic animal Hydra, which undergoes continual self-renewal, lacks senescence and has incredible regenerative capabilities.
Dr. Celina Juliano is an Assistant Professor at the University of California, Davis. Her lab studies development and regeneration in the aquatic animal Hydra, which undergoes continual self-renewal, lacks senescence and has incredible regenerative capabilities.
Dr. Rameen Shakur is the Jansen Fellow in Cardiology and Personalized Medicine at the Koch Institute for Integrative Science at MIT, and the Founder of the medical device and algorithm company Cambridge Heartwear Ltd.
Guest: Dr. Stephane Angers is a Professor and Associate Dean of Research in the Leslie Dan Faculty of Pharmacy at the University of Toronto. He is an expert in the field of signal transduction, working…
Guest: Dr. Paul Burridge is an Assistant Professor in Pharmacology at Northwestern University’s Feinberg School of Medicine. Dr. Burridge’s lab uses human iPSCs and other next-gen technologies in pharmacogenomics, disease modeling, and regenerative medicine. Currently,…
Intro: Back in June 2019, we attended the International Society for Stem Cell Research’s (ISSCR) annual conference in Los Angeles, California! Here is the last of three special episodes featuring interviews with some of the…
Guest: Dr. Pekka Katajisto is an Associate Professor at the University of Helsinki and at the Karolinska Institutet. His laboratory studies both stem cell intrinsic and extrinsic mechanisms altering tissue renewal capacity, and how such…
Intro: Back in June 2019, we attended the International Society for Stem Cell Research’s (ISSCR) annual conference in Los Angeles, California! Here is the second of three special episodes featuring interviews with some of the…
Guest: Dr. Alysson Muotri is a Professor in the Departments of Pediatrics and Cellular & Molecular Medicine at the University of California, San Diego School of Medicine, and the Co-Director of the UCSD Stem Cell…
Intro: Back in June 2019, we attended the International Society for Stem Cell Research’s (ISSCR) annual conference in Los Angeles, California! Here is the first of three special episodes featuring interviews with some of the…
Guest: Dr. Steve Szilvassy is the Senior Director, Head of Hematopoietic Products R&D at STEMCELL Technologies. He has over 25 years of experience in the field of hematology and oncology as a research scientist and…
Guest: Dr. Ubaka Ogbogu is an Associate Professor cross-appointed to the Faculties of Law and Pharmacy & Pharmaceutical Sciences at the University of Alberta. He is interested in the ethical, legal and societal implications of…
Guest: Dr. Jennifer Adair is an Assistant Member in the Clinical Research Division at Fred Hutchinson Cancer Research Center. Her lab uses a combination of cell biology, molecular biology, chemistry, engineering, nanomedicine and bioinformatics to…
Guest: Dr. Arun Sharma is a Senior Research Fellow in the Svendsen lab at Cedars-Sinai. His research focuses on the applications of iPSCs for studying cardiovascular biology, modeling diseases in a dish with genome editing…
Guest: Dr. James Hudson is Group Leader of the Organoid Research Laboratory at the QIMR Berghofer Medical Research Institute in Brisbane, Australia, whose research is focused on developing state-of-the-art bioengineering approaches for human 3D organoids…
Guest: Dr. Tannishtha Reya is a Professor of Pharmacology and Medicine at the University of California, San Diego. Her lab focuses on understanding the signaling pathways that regulate the choice between stem cell renewal and…
Guest: Dr. Bertie Göttgens is a Professor of Molecular Hematology at the University of Cambridge. His lab studies how transcription factor networks control the function of hematopoietic stem cells, and how mutations that perturb such…
Guest: Dr. Adrian Teo is a Principal Investigator at the Institute of Molecular and Cell Biology at the Agency for Science, Technology and Research (A*STAR) in Singapore. His research focuses on using stem cell technology…
Guest: Dr. Rita Perlingeiro is the Lillehei Professor in Stem Cell and Regenerative Cardiovascular Medicine at the Lillehei Heart Institute. Her lab is interested in understanding the molecular mechanisms controlling lineage-specific differentiation of pluripotent stem…
Guest: Dr. Josef Penninger is the Director of the Life Sciences Institute at the University of British Columbia and a Canada 150 Chair in Functional Genetics. He was previously the Scientific and Founding Director of…
Guest: Dr. Kristen Brennand is a stem cell biologist working to bridge the fields of developmental neuroscience and psychiatry. A major focus of her work is in developing in vitro models for schizophrenia in order…
Guest: Dr. Robert Mays is the Co-founder and Vice President of Regenerative Medicine and Head of Neuroscience Programs at Athersys Inc. He focuses on Athersys’s proprietary stem cell product, MultiStem®, and its applications in Regenerative Medicine…
Guest: Dr. Andrew Murphy is an Associate Professor at the Baker Heart and Diabetes Institute and Monash University in Melbourne, Australia. He seeks to understand the processes by which hematopoietic stem cells and the bone…
Guest: Dr. Paul Frenette is the Chair and Director of the Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at the Albert Einstein College of Medicine. His lab is interested…
Guest: Dr. Stephanie Willerth is an Associate Professor and Canada Research Chair at the University of Victoria. Her research focuses on using engineering-based approaches to stem cell biology. Her team develops bioactive scaffolds for directing…
Guest: Dr. James Wells is the Director for Research in the Division of Endocrinology at Cincinatti Children’s Hospital, as well as the Chief Scientific Officer at the Center for Stem Cell and Organoid Medicine (CuSTOM).…
Guest: Dr. Carla Kim is a Professor in the Division of Hematology/Oncology and Pulmonary Respiratory Diseases at Children’s Hospital Boston, as well as in the Department of Genetics at Harvard Medical School and in the…
Guest: Dr. Jeffrey Millman is an Assistant Professor of Medicine and Biomedical Engineering at the Washington University in St. Louis. His research focuses on the in vitro production and study of pancreatic insulin-producing β cells from human pluripotent…
Guest: Dr. Sandra Ryeom is the Assistant Professor of Cancer Biology at the Perleman School of Medicine, University of Pennsylvania. Dr. Ryeom’s lab focuses on understanding the contribution of endothelial cells in different organs towards…
Guest: Dr. Karun Singh is the principal investigator and David Braley Chair in Human Stem Cell research and Associate Professor at the Department of Biochemistry and Biomedical Sciences. The overall goal of Dr. Karun Singh’s research…
Guest: Dr. Pamela Robey is a senior investigator at the National Institute of Dental and Craniofacial Research at the NIH. Dr. Robey’s work focuses on skeletal biology, and the characteristics and biological properties of bone…
Guest: Dr. Pamela Robey is a senior investigator at the National Institute of Dental and Craniofacial Research at NIH. Dr. Robey’s work focuses on skeletal biology, and characteristics and the biological properties of bone marrow…
Guest: Dr. Benjamin Dekel is a leading investigator in the field of human renal stem cell biology and regenerative medicine. He is the Head of the Pediatric Stem cell Research Institute and the Director of the Division…
Guest: Dr. Tsvee Lapidot is a stem cell researcher who studies blood stem cells and has an interesting study out in Cell Stem Cell looking at the influence of circadian rhythms on regulation of these…
Guest: Dr. Louis Vermeulen is a Principal Investigator at the Center for Experimental Molecular Medicine at Academic Medical Center, Amsterdam, The Netherlands, where he is focusing on the role of stem cells in colorectal cancer development…
Guest: Dr. Kelly Frazer is a professor and the founding chief of the Division of Genome Information Sciences in the Department of Pediatrics, Director of UC San Diego’s Institute for Genomic Medicine and a leader…
Guest: Dr. Joseph C. Wu, MD, PhD is Director of the Stanford Cardiovascular Institute and Simon H. Stertzer Endowed Professor in Department of Medicine (Cardiology) and Department of Radiology at the Stanford School of Medicine. Dr. Wu is a pioneer in…
Guest: Dr. Charles Murry is the Woods Professor of Pathology, Bioengineering and Medicine/Cardiology at the…
Guest: Dr. David Knapp is a post-doctoral fellow at the university of Oxford. Colin Hammond is…
Guest: Samantha is an enthusiastic Science Communicator completing her PhD at the University of Toronto. Her…
Intro: In early 2018, STEMCELL Technologies put out a call for scientists to visit their…
Guest: Dr. Joseph Ciacci, MD, is a board-certified neurosurgeon with extensive experience in neuro-oncology of…
Guest: Dr. Benjamin Freedman is an Assistant Professor of Medicine at the University of Washington School…
Guest: Dr. Nicolas Rivron leads the laboratory for synthetic embryology at the MERLN Institute for…
Guest: Peter Lengyel is the co-founder and “Beer Commander” of Kings County Beer Collective in…
Guest: Dr. Valeria Orlova is the Principal Investigator at the Leiden University Medical Center. Dr.…
Guest: Evangelos Kiskinis, PHD is the Assistant Professor in Neurology at Northwestern University. His lab…
Guest: Dr. Janet Rossant is a Senior Scientist in the Developmental & Stem Cell Biology…
Guest: Dr. Nenad Bursac talks about a technology his group has developed and tested as…
Guest: Dr. William Dunsworth is the account manager at STEMCELL Technologies and will be talking…
Guest Dr. Justin Ichida is the Assistant Professor in the Department of Stem Cell Biology…
Guest Dr. Fernando Camargo is a Principal Investigator at Boston Children’s Hospital and Professor in…
Guest Dr. Kapil Bharti is a principal investigator at the National Eye Institute at the…
Guest Dr. April Pyle is an Associate Professor in the Department of Microbiology, Immunology and…
Welcome to Episode 107 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to introduce our podcast listeners to another one of the 20 weekly […]
Welcome to episode 106 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to let listeners know about another one of their weekly science newsletters, […]
Welcome everyone to Episode 105 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, as Scientists Helping Scientists, STEMCELL Technologies offers several resources to help scientists stay current and […]
Welcome everyone to Episode 104 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to share Hematopoiesis News, another one of Connexon’s 20 weekly science […]
Welcome everyone to Episode 103 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to share Hematopoisis News, another one of Connexon’s 20 weekly science […]
Welcome everyone to Episode 102 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to know what you think about the podcast. Please go to […]
Welcome everyone to Episode 101 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to know what you think about the podcast. Please go to […]
Welcome everyone to Episode 100 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for our newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to know what you think about the podcast. Please go to our website (stemcellpodcast.com) and click on the picture […]
Welcome everyone to Episode 99 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to remind listeners of the first ever Connexon newsletter, Cell Therapy […]
Welcome everyone to Episode 98 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies is excited to remind listeners about Neural Cell News, one of Connexon’s most popular newsletters. Neural Cell News covers the latest […]
Welcome everyone to Episode 97 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to introduce Cord Blood News, a newsletter that we haven’t mentioned […]
Welcome everyone to Episode 96 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL would like to introduce Connexon’s three immunology newsletters: Immunology of Infectious Disease News, Human […]
Welcome everyone to Episode 95 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies introduces Pulmonary Cell News. Covering everything lung, from COPD to CF to cancer, […]
Welcome everyone to Episode 94 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies introduces a newer Connexon newsletter: Muscle Cell News. Muscle Cell News covers all […]
Welcome everyone to Episode 93 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, STEMCELL Technologies would like to remind everyone about one of Connexon’s most popular newsletters, Neural […]
Welcome everyone to Episode 92 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, we’d like to remind listeners of one of Connexon’s original newsletters, Mesenchymal Cell News. Covering […]
Welcome everyone to Episode 91 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. In this episode, we talk with Dr. Rick Horwitz and Dr. Graham Johnson of the Allen Institute for Cell Science in Seattle The […]
Welcome everyone to Episode 90 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. The Science Round Up For this week’s round-up, we have another Connexon Newsletter to introduce this week: Extracellular Matrix News! ECM News is […]
Welcome everyone to Episode 89 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up or re-subscribe (if you are a current subscriber) for the newsletter. We start the show with an exciting announcement that will help keep The Stem Cell Podcast stay around and be available to all […]
Welcome everyone to Episode 88 of The Stem Cell Podcast. On this episode, we speak with Dr. Shawn Hingtgen on the topic of “Homing Neural Stem Cells.” The Science Round Up This week’s science round-up is sponsored by Neural Cell News, which is sent to more than 5000 neuroscience researchers every week. Sign up at neuralcellnews.com to […]
Welcome everyone to Episode 87 of The Stem Cell Podcast. On this episode we speak with Dr. Justin Lathia on the topic of “Cancer Stem Cell Evasion”. The Science Round Up For this week’s Science Round Up, we’d like to introduce one of Connexon’s most popular newsletters, Cancer Stem Cell News. As with all of Connexon’s […]
Welcome everyone to Episode 86 of The Stem Cell Podcast, where we feel it is really important for us to deliver you content that is current, as it’s happening. At the end of January a story was published in Cell describing, for the first time, a human-pig chimera. The story received a lot of mainstream press and is […]
Welcome everyone to Episode 85 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up This week’s round-up is sponsored by Cell Therapy News (CTN), the original Connexon newsletter. Launched in 2002, Cell Therapy News has been covering the world of stem cell […]
Welcome to episode 84 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world-famous Science Round Up and discuss the latest science/stem cell news including: Rumors about Trump’s science adviser pick. Heart hugging robots. Marijuana deserves more scientific […]
Welcome everyone to Episode 83 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up Last week we introduced the Connexon Newsletters as a new partner for the Science Roundup. Connexon has been publishing free, weekly newsletters that curate the latest research and news […]
Happy New Year everyone and welcome to Episode 82 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up and discuss the latest science/stem cell news. Given this is the last episode of the year […]
Welcome everyone to Episode 81 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up and discuss the latest science/stem cell news including: Microcephaly cases surge in Columbia due to Zika. Extra chromosome slows cancer cell growth. […]
Welcome everyone to Episode 80 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up and discuss the latest science/stem cell news including: Dogs form memories of experiences. Lower social status affects immune system. A new fetal […]
Welcome everyone to Episode 79 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up and discuss the latest science/stem cell news including: New antibody therapy for Zika. Single cell small RNA sequencing. President-Elect Trump and […]
Welcome everyone to Episode 78 of The Stem Cell Podcast where we discuss the stem cell hamburger. Please visit stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up and discuss the latest science/stem cell news including: Time for an update to science text books? Identifying […]
Welcome everyone to Episode 77 of The Stem Cell Podcast. With the election right around the corner we wanted to take a departure from the “norm” and discuss how the election might impact science and science policy. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin […]
Welcome everyone to Episode 76 of The Stem Cell Podcast during which we talk to stem cell biologist Dr. Stephen Duncan on the topic of the purification of cell lineages derived from pluripotent stem cells. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the […]
Welcome everyone to Episode 75 of The Stem Cell Podcast, in today’s episode we discuss stem cells and culture conditions with Dr. Joshua Brickman. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up and discuss the latest science/stem cell news including: […]
Welcome everyone to Episode 74 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: A ban on antibacterial soap. Zika virus spreading through Florida. A new […]
Welcome everyone to Episode 73, where we talk some stem cell business. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news. This episode’s topics include: Non for Profit Wants Your Dog’s DNA? […]
Welcome everyone to Episode 72 of The Stem Cell Podcast. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: Young sunflowers use circadian rhythms to follow the sun. Young people agree […]
Welcome to Episode 71 where we will discuss stem cells and breast cancer. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: Antibiotics may help fight Alzheimer’s disease. Nail biting and thumb […]
Welcome everyone to Episode 70 on new MS therapies. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: Greasy heads help swordfish swim. Big hole in ozone layer is closing. […]
Welcome everyone to Episode 69, “Politics, Parkinson’s and More” Featuring Dr. Raj Kittappa! As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: Wine being made 6,300 years ago? Driverless car […]
Welcome everyone to Episode 68. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: Imodium AD overdoses? Sense of touch and Autism. New names for elements on periodic table. Genomic […]
Welcome to Episode 67 on Blood Stem Cell Therapy with guest Dr. Kristin Hope. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: doctors say Olympics should be postponed […]
Welcome aboard everyone to Episode 66, we are back with another informative episode. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. We begin with the world famous Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: scientists talk about creating synthetic human genome second skin reduces […]
Alright everyone, we are back with an exciting show with a timely topic: Zika Virus. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. The Science Round Up We start off as always with the Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including: Zika virus […]
Welcome back for another episode of THE Stem Cell Podcast. We are excited about today’s episode with Dr. Kateri Moore. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. You can also check out stemcellchannels.com to see everything we have to offer and follow us on social media. The Science Round […]
Alright everyone, we are so happy to be back after our short podcast break, and we are excited to kick things off with a fantastic guest. As always go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. In this episode, our new hosts Dr.Kiki and Dr. Daylon James, […]
Alright everyone, here is Episode 62, “Forever Young” featuring Dr. Aubrey de Grey. This and all of our episodes are sponsored by Thermo-Fisher Scientific. Go to stemcellpodcast.com for all of our episodes and to sign up for our newsletter.
We begin as always with the Science Round Up, sponsored by Biotechne and discuss the latest science/stem cell news including:
differences in males and females stress susceptibility
key elements of healthy eating habits
a new marker of stem cells in the ovaries
engineered stem cells may help in ALS
how squeezing cells can help reprogramming efficiency
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on writer, and researcher Dr. Aubrey de Grey to discuss his work on anti-aging. We talk with Dr. de Grey on his latest findings and his ultimate goal of eliminating aging so we call can one day celebrate our 1000th birthday. After this, there is a rant about how ridiculous cable bills are.
This will be our last episode before we take a short break. Remember, during the break we will still do a science round up and some sort of interview feature that we will post online. Be sure to sign up for our newsletter at stemcellpodcast.com and follow us on twitter to find out:
when the podcast will re-launch
who the new hosts are
where to access the science round up
Talk to you SOON!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Sex-Specific Mechanisms of Stress Susceptibility – According to this article, stress-related mental illnesses are twice as prevalent in women as in men.
Global Divergence Of The Human Follicle Mite Demodex folliculorum: Persistent Associations Between Host Ancestry And Mite Lineages – In this article, researchers found that hosts with different regional ancestries harbor distinct lineages of mites and that these associations can persist despite generations spent in a new geographic region.
Pain Produces Memory Gain – This article reveals that physical pain can make memories last longer.
Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses – In this article, researchers performed two integrated, multi-cohort analyses of publicly available transcriptional data of viral infections.
Human Parasites in the Roman World – This article presents the archaeological evidence for parasites in the Roman era in order to demonstrate the species present at that time, and highlight the health consequences for people living under Roman rule.
Happy New Year everyone, thanks for all the support in 2015 and looking forward to a great 2016. The Stem Cell Podcast is presented by Thermo-Fisher Scientific, please go to stemcellpodcast.com for all our episodes and to sign up for our newsletter. In this episode we start with our signature science roundup, a quickie but goodie. Some of the papers we discuss include:
New elements added to the periodic table
Stem cells to save the endangered white rhino species
A new way to make serotonin neurons
Human stem cells injected into a mouse embryo
Stem cells can make cells that help functionally recover a model of spinal cord injury.
For the interview portion of the show sponsored STEMCELL Technologies, we feature some of our conversations with attendees from the 2015 World Stem Cell Summit from Atlanta, GA. Finally we close with a rant on noisy radiators and how heat dries out your nose.
Happy New Year!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
4 New Elements Are Added To The Periodic Table – This article reports that the elements with atomic numbers 113, 115, 117 and 118 will get permanent names soon, according to the International Union of Pure and Applied Chemistry, with two of the four elements now known as ununseptium and ununtrium.
New Type Of Moon Rock Discovered By China's Yutu Lunar Rover – In this article, China's Yutu lunar rover made the discovery on a long-dead lava flow in the giant Mare Imbrium dark spot and found the volcanic rock known as basalt which has intermediate levels of titanium.
CMV Vaccine Created at City of Hope is Found Safe, Effective in Patients Receiving Stem Cell Transplants – According to this article, City of Hope researchers now report that an innovative vaccine known as CMVPepVax that boosts cellular immunity against cytomegalovirus, or CMV is safe and effective in stem cell transplant recipients.
Melting Sea Ice Increases Arctic Precipitation, Complicates Climate Predictions – This article reports that the melting of sea ice will significantly increase Arctic precipitation, creating a climate feedback comparable to doubling global carbon dioxide, according to the findings of Dartmouth College-led study.
Eating Poorly And Depressed? Yale Team Finds Connection — And Maybe A Solution – In this article, Yale researchers report that effects of a high-fat diet overlap with those of chronic stress and could also be a contributing factor in depression as well as metabolic disorders such as Type 2 diabetes.
MERS Vaccine Protects Camels, Which Is Good for People – According to this article, the vaccine, which was developed by German scientists,
First off thank you everyone for listening to us in 2015, we had a really great year and excited for what’s to come in 2016! Our current show is Episode 60, “Stemcentrx” ft. Dr. Scott Dylla. The Stem Cell Podcast is presented by Thermo-Fisher Scientific, please go to stemcellpodcast.com for all our episodes and to sign up for our newsletter. In this episode we do not do a traditional science round but instead review some of the talks that can be found on the 24 Hour of Stem Cell event put on by Thermo-Fisher. Some of these talks include:
Bio-materials for stem cells and organoids
Activity of neurons firing in a dish
Tissue engineering for cardiac repair
Modeling predisposition to schizophrenia using iPS cells
shRNA screens identify regulators of stem cell self-renewal.
For our interview we bring on Scott Dylla, CSO and co-founder of Stemcentrx a really cool new company that is using novel technology to target stem cells as a therapy for different cancers. Finally we close out the year with a rant on making up solutions that won’t dissolve.
Happy Holidays and New Year!
Photo Reference: Courtesy of Scott Dylla
Thanks for tuning in for Episode 59 of The Stem Cell Podcast, “Clinical Grade” featuring Dr. Tilo Kunath. This and all of our episodes are presented by Thermo-Fisher Scientific. Go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. We begin as always with the Science Round Up and discuss the latest science and stem cell news including:
A way to grow stem cells on seaweed
A meeting describing the state of disease modeling using stem cells
Sleep derivation affects stem cell transplants
Cranberry juice just as effective as antibiotic for urinary tract infections
Smoking really strong weed strains can affect your brain
A new way to make retinal cells from stem cells
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on researcher Dr. Tilo Kunath to discuss his work on characterizing clinical grade stem cells so they can be used for patient therapies. We talk to Tilo about his past and current work including his latest paper published in Science Reports. Don't miss Tilo's funny story and extra pictures to go with it! Finally we close the show with our signature rant on Centigrade versus Fahrenheit. Be sure to continue the discussion on stemcellchat.com. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Boeing Develops New Metal That Could Revolutionise Aeroplanes – In this article, Boeing reveals microlattice: a metal so thin that it can sit on the head of a dandelion.
Smoking High-Strength Cannabis May Damage Nerve Fibres In Brain – According to this article, people who regularly smoked strong skunk-like cannabis revealed subtle differences in the white matter that connects the left and right hemispheres and carries signals from one side of the brain to the other.
A Breakdown Product Of Aspirin Blocks Cell Death Associated With Alzheimer's, Parkinson's And Huntington's Diseases – In this article, a new study finds component of aspirin binds to an enzyme called GAPDH, which is believed to play a major role in neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases.
Sleep Deprivation Affects Stem Cells, Reducing Transplant Efficiency – In this article, researchers found that a sleep deficit of just four hours affects by as much as 50 percent the ability of stem cells of the blood and immune system to migrate to the proper spots in the bone marrow of recipient mice and churn out the cell types necessary to reconstitute a damaged immune system.
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy – This article shows that selective activation of ER stress underlies motor neuron (MN) death in spinal...
Thanks for tuning in for Episode 58, “Heart Disease Modeling” featuring Dr. Lior Gepstein. This and all of our episodes are sponsored by Thermo-Fisher Scientific. Go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. We begin as always with the Science Round Up and discuss the latest science/stem cell news including:
Discovery of a new STD.
Stem cells generated from urine used to help discover new drugs for cholesterol disease?
A new stem cell method to model diseases of the muscle.
A stem cell company bought out for 380 million dollars.
Impaired sense of smell may indicate dementia.
More NFL stars going for stem cell therapies.
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on clinician and researcher Dr. Lior Gepstein to discuss his work on using stem cells to model heart disease. We talk to Dr. Gepstein about his past and current work including his latest paper published in Stem Cell Reports. Finally we close the show with our signature rant on plastic stickers on fruit. Be sure to continue the discussion on our new free forum Stem Cell Chat. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Antibiotic Resistance: World On Cusp Of 'Post-Antibiotic Era' – According to this article, the world is on the cusp of a "post-antibiotic era", scientists have warned after finding bacteria resistant to drugs used when all other treatments have failed.
MG, The Newest STD On The Block, Found In Over 1% Of The Population – This article reports that slightly more than 1 percent of 4,500 participants tested positive for a sexually transmitted disease known as Mycoplasma genitalium (MG).
Parasitic Worm 'Increases Women's Fertility' – This article suggests that infection with a species of parasitic round worm, Ascaris lumbricoides that alters the immune system, makes it easier for women to get pregnant.
How A Raisin Can Predict A Toddler's Future Academic Ability – According to this article, a simple test using a raisin can predict how well a toddler will perform academically at age eight, based on a research conducted at the University of Warwick.
Uterus Transplant: First US Clinical Trial Begins – This article reports that the first clinical trial of uterus transplantation in the United States has begun at Cleveland Clinic in Ohio, and in the process of selecting women with uterine factor infertility (UFI), a condition in which a woman was born without a uterus, has lost her uterus, or has a uterus that no longer functions.
Viagra For Type 2 Diabetes: 'Little Blue Pill' Reduces Insulin Resistan...
Thanks for tuning in for Episode 57, “Curiosity” featuring Duane Fernandez. This and all of our episodes are sponsored by Thermo-Fisher Scientific. Go to stemcellpodcast.com for all of our episodes and to sign up for the newsletter. We begin as always with the Science Round Up and discuss the latest science/stem cell news including:
A woman that can smell Parkinson’s disease?
Will we ever be able to treat female infertility with stem cells?
A new gene that regulates the stem cell number
A new stem cell model of bi-polar disorder
A common allergy medication might help your brain
For the interview portion of the show, sponsored by STEMCELL Technologies, we bring on writer, director and photographer Duane Fernandez to talk about how curiosity drives him and his work. We talk to Duane on his experience with helping people from all walks of life and business experience their true potential and how this can apply to science. Finally we close the show with our signature rant on labeling tubes. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
The Woman Who Can Smell Parkinson's Disease – According to this article, a woman from Perth named Joy Milne who can detect people with Parkinson’s through a telltale odor.
Neurons from Glia In Vivo – In this article, scientists present new recipes for directly converting glial cells to neurons in mouse brains.
Exclusive Video: First "Glowing" Sea Turtle Found – This article reports that scientists diving recently near the Solomon Islands made an illuminating discovery: The first biofluorescent reptile ever recorded.
Japanese Scientist Haruko Obokata Stripped Of Doctorate Over Stem Cell Scandal – This article announces that Waseda University has revoked a doctoral degree awarded to a young researcher embroiled in a scandal that has rocked the scientific establishment.
Fighting Citrus Greening With Vibrating Orange Groves – According to this article, hijacking the mating signals of Asian citrus psyllids may help provide an environmentally friendly system for preventing citrus greening -- a disease that has cost the Florida citrus industry billions of dollars in recent years.
Neurons Reprogrammed In Animals – In this article, Harvard Stem Cell Institute researchers have now shown that the networks of communication among reprogrammed neurons and their neighbors can also be changed, or “rewired.”
Thanks for tuning in to Episode 56, Glia featuring Dr. Steven Goldman. This and all of our episodes are sponsored by
Happy Stem Cell Awareness Day SCP fans and welcome to Episode 55. Be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin this episode by answering some questions from you the audience, thank you to everyone that submitted their questions and apologies to those that we could not get to. After this we do a mini-Science Roundup sponsored by Thermo Fisher including:
Creation of rudimentary kidneys from stem cells
A new method to generate "old" neurons
A new company created to create genetically modified pigs
Flowing water found on Mars
For the interview portion of the show, sponsored by Stem Cell Technologies, we bring on Dr. David Mooney, Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences to discuss his work using Biomaterials to help stem cells more efficiently integrate after transplantation. We then finish off the show with a rant on automatic flushing toilets. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Gene-Editing Record Smashed In Pigs – In this article, researchers modify more than 60 genes using CRISPR/Cas9 gene-editing technology in effort to enable organ transplants into humans.
NASA Discovers Evidence for Liquid Water on Mars – According to this article, NASA scientists have found compelling evidence that liquid water exists on Mars based on the “recurring slope lineae,” patches of precipitated salt that appear to dribble down Mars’ steep slopes like tears rolling gently down a cheek.
Article Mentioned in the Stem Cell Day Questions Answered Section:
Stem Cell Fraud: A 60 Minutes Investigation – In this article, Scott Pelley confronts one disgraced doctor offering false hope to a family with a disabled child using unproven stem cell treatment.
Photo Reference: Courtesy of Dr. David Mooney
Welcome everyone to Episode 54. Be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by
Welcome SCP fans to Episode 53. Be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter....
Welcome SCP fans to Episode 52 and thanks as always for tuning in. Be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode, we discuss topics ranging from STAP author accusations, stem cells go to space, different types of bacteria in homes, tricking the body to fight colon cancer stem cells, growing a human brain in the lab, the female “viagra” is now available, and much more. For the interview portion of the show, sponsored by Stem Cell Technologies, we bring on Dr. Flora Vaccarino from Yale University to discuss stem cells and autism, specifically her work on neural stem cells and how she is using them to study Autism Spectrum Disorder. We then finish off the show with a rant on the metal tops to Matrigel. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Citizen Science Effort Highlights How Little We Know About Invisible Life in Our Own Homes – According to this article, scientists are announcing the discovery of thousands of unidentified species living in and around homes in the United States.
Reprogramming Cancer Cells Back To Normal Looks Feasible, Study Shows – In this article, a new study in Nature Cell Biology suggests there may be a way to change the code so that cancer cells revert back to normal cells.
Does This Phylum Make Me Look Fat? – This article describes that beyond carbs and fats, some studies have hinted that a key group of gut microbes — from the phylum Firmicutes — might be more common among people who are overweight.
Identifying The Gene Switch That Turns Fat Cells Bad – This article reports that using state-of-the-art DNA editing tools, scientists have identified a genetic switch that helps govern the body’s metabolism.
Human Brain Grown In A Lab Could Be Most Complete Yet – According to this article, scientists have developed a miniature brain in the lab that was grown from the skin cells of an adult human and, incredibly, boasts 99% of the genes found in a human fetal brain.
Science Of Making Memories: Part Of Your Hippocampus Decides Which Experiences Are New Or Different Versions Of The Same – This article reveals that the CA3 region, a region of the hippocampus, decides what you will and can remember by answering the question: Is it the same or is it different?
Major Publisher Retracts 64 Scientific Papers In Fake Peer Review Outbreak – This article reports that in the latest episode of the fake peer review phenomenon, one of the world’s largest academic publishers, Springer, has retracted 64 articles from 10 of its journals after discovering that their reviews were linked to fake e-mail addresses.
Safeguarding Gene Drive Experiments In The Laboratory – This article suggests that multiple stringent confinement strategies should be used whenever possible in creating gene drive systems.
Estimating The Reproducibility Of Psychological Science – In this article, scientists conducted a large-scale, collaborative effort to obtain an initial estimate of the reproducibility of psychological science.
Adding Chili To Food Really CAN Help You Lose Weight: Compound In Fiery Peppers Tells The Body It's Full, Preventing Over-Eating – According to this article, eating chili peppers can activate the stomach to stretch and release the 'full-feeling' signals, stimulating a receptor called potential vanilloid 1 (TRPV1) channel protein which stops a person from overeating.
F.D.A. Approves Addyi, a Libido Pill for Women – In this article, Food and Drug Administration approved the first prescription drug to enhance women’s sexual drive.
Welcome SCP fans to Episode 51. Be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode, we discuss topics ranging f...
The Stem Cell Podcast is proud to bring you our 50th Episode. Be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode...
Welcome everybody to Episode 49, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. In this episode we give you the second part of our broadcast live from the ISSCR 2015 International Conference from Stockholm, Sweden. On the show, we randomly pull attendees aside and ask them to us their stem cell story, and detail some of their research topics and accomplishments. Some of those interviewed on the show include Dr. Sean Morrison, the President of ISSCR, and Dr. Paul Tesar of Case Western Reserve University. Because we have over 2 hours of audio, we will not do a Thermo Fisher sponsored, science roundup. After the interviews we close the show with a signature SCP rant.
Welcome everybody to Episode 48, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. In this episode we broadcast live from the ISSCR 2015 International Conference from Stockholm, Sweden. On the show, we randomly pull attendees aside and ask them to us their stem cell story, and detail some of their research topics and accomplishments. Everyone from graduate students, post-docs, patients who have received stem cell transplants, to big name researchers, we get them all. This episode will be part one, with part two continuing into Episode 49. Because we have over 2 hours of audio, we will not do a Thermo Fisher sponsored, science roundup. After the interviews we close the show with a signature SCP rant.
Welcome everybody to Episode 47, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. This is a short episode in preparation for our trip to Sweden so there will be no interview segment, just info on the latest research papers and happenings. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode we discuss topics ranging from, more sports stars getting stem cell therapy, a mutation that eliminates prion disease, a perspective on aging by studying stem cells, chimps getting drunk in the wild on there own, a Nobel laureate who made awful comments regarding women in science and your birthdate as a predictor of disease. We then finish off the show with a listener submitted rant on pedestrians not waiting for cars to pass before walking into road. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Scientists Film Death Of White Blood Cell For First Time And Discover Alert System – In this article, Australian and US scientists capture on video each stage of death of a human white blood cell, revealing the dying cells apparently try to alert their neighbors by ejecting molecules into nearby cells, possibly to alert them to the potential presence of a pathogen.
Sun Like It Hot: Philae Comet Probe Wakes Up, Phones Home Again – According to this article, European Space Agency has confirmed that the Philae probe on Comet 67P/Churyumov-Gerasimenko has been in contact again, and that the lander is getting more than enough sunshine on its solar panels to power itself continuously.
Molecules Reach Coldest Temperature Ever – This article describes how the MIT researchers chilled a gas of sodium potassium 500 nanokelvin.
New Study: Chimps Go Bananas Over Palm Wine – According to this article, scientists report that chimps in western Africa have taken to purloining drinks from vats of palm wine left unguarded by humans.
Autism Risk May Be Influenced By Age Gap Between Parents – In this article, researchers have demonstrated with the largest ever multinational study of parental age and autism risk that the children of teen mothers, older parents and parents with an age gap of 10 years or more have a higher risk of autism spectrum disorder than other children.
Nobel Prize-Winning Professor Tim Hunt Resigns After Sexist Remarks About 'Girls' In Lab – This article reports that the Nobel Prize-winning biochemist Tim Hunt stepped down from his position at the University College London after making sexist comments at the World Conference of Science Journalists in South Korea.
Your Birth Month May Predict Your Health Issues: Heart Disease Rates Higher March To June – This article explores the relationship between the month a person is born and their risk for disease according to the algorithm created by scientists from Columbia University.
Traditional Medicine: Thunder God Vine As Potential Obesity Treatment – According to this article, an extract from the thunder god vine, long used in traditional Chinese medicine, reduces food intake and causes up to a 45% decrease in body weight in obese mice because of its weight-loss compound called Celastrol, which produces its potent effects by enhancing the action of an appetite-suppressing hormone called leptin.
Virotherapy: Skin Cancer Successfully Treated With Herpes-Based Drug – This article describes how ‘Virotherapy’ uses modified herpes virus to attack melanoma cells and has potential to overcome cancer even when disease has spread throughout the body.
Pop Music's Most Important Revolution? That Would Be Hip-Hop, Science Reveals – In this article,
Welcome everybody to Episode 46, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode, we discuss topics ranging f...
Welcome everybody to Episode 45, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode, we discuss topics ranging from stem cell controversy still with Gordie Howe, does GDF11 really make you young, making morphine in yeast, restoring brain plasticity in mice, positive results from a RPE clinical trial for AMD, spreading of stem cell tourism and now FDA steps in, and more. Then we bring on Alex Hannay, product manager at Thermo Fisher to talk about the process of differentiation from pluripotent stem cells and new products that could help. Check out www.lifetechnologies.com/differentiation for more info. We then finish off the show with a rant on convenience fees. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
This Genetically Modified Yeast Can Now Brew Morphine – According to this article, biologists in California and Canada have created strains of yeast that can feast on sugar and make opiates – the key ingredients in pain relievers like morphine.
Juvenile Plasticity Returned To Adult Mice Brains – In this article, UC Irvine scientists have managed to make an old brain young again by transplanting a type of embryonic neuron into the brains of adult mice.
Why Do Men Still Exist? Scientists Finally Find The Answer – This article suggests that sexual competition for mates keeps populations healthy, free of disease and genetically diverse.
Discovery Of Rare Quadruple Quasar System Baffles Astronomers – In this article, astronomers have discovered four of the rare, super-luminous celestial objects known as quasars arrayed in close proximity to one another.
New Test Detects Drug Use From A Single Fingerprint – This article describes a new, non-invasive test presented by researchers that can detect cocaine use through a simple fingerprint.
Ocata Therapeutics Announces Positive Results in Treating Macular Degeneration Using Fully Differentiated Stem Cell-Derived Retinal Pigment Epithelium (RPE) Cells in Asian Patients – In this article, Ocata Therapeutics, Inc. announces a study that has been published that includes top-line, positive results in Asian patients who were treated with Ocata’s proprietary RPE cells, manufactured using its DeltaCell™ Technology.
First Database Of Brain-Cell Types Released By Allen Institute – In this article, Seattle’s Allen Institute for Brain Science has released the first database of brain cell types, along with new analysis to improve treatment of deadly brain cancer.
'Brain Wiring' May Influence Ability To Quit Smoking Successfully – According to this article, researchers from Duke Medicine in Durham, NC found that even with the help of nicotine replacement therapy and other smoking cessation aids, some smokers are just unable to quit the habit because their brains are not hard-wired to.
Drug-Resistant Strain Of ‘Superbug’ Typhoid Spreads Worldwide – This article reveals that an antibiotic-resistant “superbug” strain of typhoid fever has spread globally, driven by a single family of the bacteria, called H58.
Male Sperm Cells Grown For First Time: French Laboratory – According to this article, scientists from Kallistem, a company in Lyon, France had successfully transformed scraps of genetic material into fully functioning sperm.
Gordie Howe Still At Center Of Stem Cell Controversy – This article discusses the controversy and debate between the families of John Brodie and Gordie Howe who received stem cell treatments after suffering from massive strokes and other skeptics.
Welcome everybody to Episode 44, be sure to visit stemcellpodcast.com for current and past episodes and to subscribe to our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode we discuss topics ranging from a chemical in vegetables that can destroy cancer stem cells, chewing gum to prevent signing a song over and over, the first report of germ line gene editing in human embryo, neuronal hyperactivity and neutral stem cells, and the discovery of a new pluripotent stem cell. The second half of the show comes live from The Next-Gen Stem Cell Conference in Saratoga NY, where we interview 4 scientists about their work and conference experience. We then finish off the show with a rant about salt and pepper shakers. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Could High Blood Sugar Be A Cause Of Alzheimer's Disease? – In this article, scientists suspect one of the drivers that causes the complex brain changes that lead to Alzheimer’s disease is the accumulation of plaques of a faulty protein called beta-amyloid and that too much sugar in the blood can speed up the production of this protein.
Activin A Directs Striatal Projection Neuron Differentiation Of Human Pluripotent Stem Cells – This article reports that activin A induces lateral ganglionic eminence (LGE) characteristics in nascent neural progenitors derived from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) in a sonic hedgehog-independent manner.
Take A Deep Breath: Patients Find Relief Through 3d Printing – According to this article, a patient suffering from the rare condition, tracheobronchomalacia was treated with the use of 3D printing to construct a splint that would support the weakened trachea.
Relaxed DNA May Contribute To Aging – In this article, analysis from scientists suggests that loosely wrapped DNA underlies the accelerated physical decline of Werner syndrome and promotes aging in the rest of the population.
U of M Institute Discovers How Aspirin Fights Cancer – According to this article, researchers discovered that aspirin might exert its chemopreventive activity against colorectal cancer, at least partially, by normalizing the expression of epidermal growth factor receptor (EGFR) in gastrointestinal precancerous lesions.
Bat-Winged Dinosaur Discovery Poses Flight Puzzle – This article describes the fossilized remains of a small, feathered dinosaur, unearthed in eastern China, that probably sported bat-like wing membranes and might have been able to glide or fly short distances.
A Step Toward Making Everybody A Universal Blood Donor – In this article, researchers describe a way to transform A and B blood into a type that, like O, could be universally donated by using enzymes to remove certain sugars in the blood.
The Search For Satiety Neurons And How To Short Circuit Hunger – According to this article, a team of researchers has found that a melanoncortin 4 receptor-regulated (MC4R) circuit serves as the neural link that inhibits and controls eating by promoting fullness and removing the almost painful sensation of grating hunger.
Finding The Body Clock's Molecular Reset Button – In this article, the researchers at McGill and Concordia universities in Montreal, report that the body's clock is reset during the process, known as phosphorylation when a phosphate combines with a key protein in the brain.
Chew Gum To Get Rid Of That Song In Your Head: Study – This article reveals that chewing gum could be the best way to get rid of the annoying songs that play in our heads which some call as earworms,
Welcome everybody to Episode 43, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode we discuss topics ranging from, a new blood test to predict future breast cancer, chimps used tools to hunt, a new all vegan cheese, drugs that activate endogenous stem cells in the CNS, and more. Then we bring on two guests, Dr. Megan Munsie and Dr. Mario D'Cruz where we discuss the launch of ISSCR's new website "A Closer Look At Stem Cells" that aims to educate and empower people about stem cell biology and stem cell treatments. We then finish off the show with a rant about driving pet peeves.
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
The Number One Cause Of Depression — Everywhere – According to this article, a group of researchers from around the world discovered that people who have suffered from abuse during their childhood are more likely to be diagnosed with clinical depression — and even more so if they are genetically predisposed to the condition.
Major Advance in Artificial Photosynthesis Poses Win/Win for the Environment – In this article, artificial photosynthesis has been achieved with the development of a system that can capture carbon dioxide emissions before they are vented into the atmosphere and then, powered by solar energy, convert that carbon dioxide into valuable chemical products, including biodegradable plastics, pharmaceutical drugs and even liquid fuels.
Resistance To Antibiotics Found In Isolated Amazonian Tribe – In this article, scientists discovered that Yanomami hunter-gatherers’ gut bacteria have already evolved a diverse array of antibiotic-resistance genes, even though these mountain people had never ingested antibiotics or animals raised with drugs.
Sarcasm Center Found In Brain's White Matter, Explaining Stroke Victims' Language Gap – According to this article, stroke victims often struggle to maintain language function, and regions governing sarcasm may get hit particularly hard.
Danish Researchers Develop New Blood Test Able to Predict Future Breast Cancer – In this article, scientists at the University of Copenhagen developed a blood test method that can predict future breast cancer, which led to better prevention and early treatment of the disease.
Chimps Use Spears To Hunt – This article describes the capability of a troop of chimpanzees in southeastern Senegal to forge weapons to hunt, making them the only known group to use tools to injure or kill prey, and it turns out that females actually engage in this behavior more than males.
Wild Chimps In Uganda Have Learned To Look Both Ways When Crossing The Roads – According to this article, wild chimpanzees are beginning to realize the importance of crossing roads safely, as scientists have observed them implementing similar safety precautions to us, such as looking both ways for oncoming traffic.
Cow Milk Without the Cow Is Coming to Change Food Forever – In this article, a group of bio-hackers are trying to trick yeast cells into producing a substance that’s molecularly identical to milk using mail-order DNA.
Drug-Based Modulation Of Endogenous Stem Cells Promotes Functional Remyelination In Vivo – This article shows how scientists look into seven drugs function at nanomolar doses selectively to enhance the generation of mature oligodendrocytes from progenitor cells in vitro.
Sale Of Madison Company Could Be A Big Step For Stem Cell Research – According to this article, the pending sale of Madison's Cellular Dynamics International Inc.
Welcome everybody to Episode 42, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode we discuss topics ranging from, genomic analyses of brain tumors, cheap long lasting cell phone batteries, expansion microscopy, feeder stem cell culture may be better than feeder free, hESCs are not being used as gold standard as much anymore, stem cells for dogs, a new RIKEN president, a new possible model for liver disease using iPSCs, etc. Then we bring on neuroscientist and stem cell pioneer Dr. Fred “Rusty" Gage, a professor at the Salk Institute where he discusses past, present, and future work of stem cells and neurogenesis. We then finish off the show with a rant on packing peanuts.
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Too Much Of A Bad Thing Can Be Good In Brain Tumors – This article revealed that DNA mutations can cause cancer but in some cases, more mutations may mean a better prognosis for patients like the one subtype of the most malignant brain tumor, called glioblastoma, or GBM.
Turbo-Charging Hormone May Help Regrow The Heart, Animal Study Shows – In this article, researchers at the Victor Chang Cardiac Research Institute discovered how to stimulate muscle regrowth in the heart of a mouse, which could be particularly important in looking at new treatments for those who suffer future heart attacks.
Aluminum Battery From Stanford Offers Safe Alternative To Conventional Batteries – According to this article, Stanford University scientists have invented the first high-performance aluminum battery that's fast-charging, long-lasting and inexpensive that could replace many of the lithium-ion and alkaline batteries in wide use today.
Blackpoll Warblers Migrate Thousands of Miles across Atlantic Ocean, Scientists Find – In this article, a team of ornithologists led by William DeLuca of the University of Massachusetts, Amherst, reports the first direct evidence that the blackpoll warbler (Setophaga striata), relatively small songbirds, completes an autumn trans-Atlantic migration ranging from 2,270 to 2,770 km (1,410 to 1,721 miles) and requiring 2 to 3 days of non-stop flight.
Africa: Biodiversity Damage Mapped By Global Land-Use Study – According to this article, study concluded that, if human impacts continue to grow as they have been, future losses in biodiversity will be concentrated in biodiverse but economically poor countries.
Blown-Up Brains Reveal Nanoscale Details – In this article, a study showed that material used in diaper absorbant can make brain tissue bigger and enable ordinary microscopes to resolve features down to 60 nanometers; this technique is called expansion microscopy.
Repurposed Experimental Cancer Drug Restores Brain Function In Mouse Models Of Alzheimer’s Disease – In this article, scientists have found that saracatinib, a compound originally developed as a cancer therapy potentially could be used to treat Alzheimer’s disease.
Stemming Genetic Changes in Cultured Cells – According to this article, researchers have found that the fewest genetic changes arise in embryonic stem cells (ESCs) that are grown on a substrate layer of “feeder cells”—non-dividing cells that provide nutrients and help ESCs attach to their culture dishes—and passaged mechanically, that is, broken into clumps before being moved into new vessels.
Study: Saccharin Shows Promise As Cancer Inhibitor – This article shows that the artificial sweetener saccharin shows considerable promise for its ability to inhibit an enzyme upregulated in many cancers,
Welcome everybody to Episode 41, be sure to visit stemcellpodcast.com for current and past episodes and to sign up for our newsletter. We begin as always with our Science Roundup sponsored by Thermo Fisher. In this episode we discuss topics ranging from, the c. elegans worm that can detect cancer in urine samples, a new autism gene, germ line genetic modifications, stem cells from sheep for face cream, a new way to make 3D mini-lungs in the dish and a new protein involved in making neurons from stem cells. Then we bring on Dr. Eirini Papapetrou, an associate professor at the Icahn School of Medicine at Mt. Sinai where she discusses her work and latest paper on using stem cells to model blood diseases containing a chromosomal deletion. We then finish off the show with a rant on the company refrigerator rules.
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Sushi Parasite Inspires Worm Test For Cancer – In this article, Japanese researchers have discovered that Caenorhabditis elegans worms can detect cancer in people's urine.
New Genetic Variant That Causes Autism Identified By Johns Hopkins-Led Team – This article reveals that a Johns Hopkins-led team of researchers has identified a new genetic cause of the disorder using a novel approach that focuses on rare families severely affected by autism.
Bad Gene Cripples Flu Defenses – This article describes how a girl nearly died from flu because of mutated genes.
High-Fat Diet Alters Behavior And Produces Signs Of Brain Inflammation – According to this article, there is a great possibility that a high-fat diet produces changes in health and behavior, in part, by changing the mix of bacteria in the gut, also known as the gut microbiome.
NASA's Opportunity Rover Just Completed An 11-Year Marathon On Mars – In this article, NASA confirmed this week that the six-wheeled robot has now traveled more than 26.219 miles in 11 years and two months.
Apple's New ResearchKit: 'Ethics Quagmire' Or Medical Research Aid? – According to this article, Apple's ResearchKit is designed to let medical researchers create iPhone apps for their studies that will help them recruit participants — without said participants ever setting foot in the lab.
Woolly Mammoth DNA Inserted into Elephant Cells – This article describes the attempt of scientists to bring extinct species back from the grave through a process known as de-extinction.
Surprise Finding Heightens Concern Over Tiny Bits Of Plastic Polluting Our Oceans – In this article, a team of scientists’ accidental finding of plastic in the skin of both farmed and wild fish adds to already growing environmental and public health concerns about the plastic particles or microplastics pervading our oceans and waterways.
Altering Brain Chemistry Makes Us More Sensitive To Inequality – According to this article, researchers finds that giving a drug that changes the neurochemical balance in the prefrontal cortex of the brain causes a greater willingness to engage in prosocial behaviors, such as ensuring that resources are divided more equally.
Engineering the Perfect Baby – In this article, a group of scientists try to edit the DNA of human germ line to correct disease genes and to pass those genetic fixes on to future generations.
Don’t Edit The Human Germ Line – According to this article, heritable human genetic modifications pose serious risks, and the therapeutic benefits are tenuous, warn Edward Lanphier, Fyodor Urnov and colleagues.
Industry Body Calls for Gene Editing Moratorium – In this article, gene-editing companies say research on altering the DNA of human reproductive cells is dangerous and unethical.
Wow, 40 episodes in the books, and we have another great episode for you. Please make sure you go to StemCellPodcast.com and sign up for our newsletter to get the latest episode and all the paper links emailed directly to you. In today's episode we s...
Welcome to another episode of THE Stem Cell Podcast. Thanks everyone for the continued support and be sure to visit stemcellpodcast.com to sign up for our e-newsletter and see all the great resources we have there for everyone. In this week's episod...
Welcome to another episode of THE Stem Cell Podcast. Thanks everyone for the continued support and be sure to visit stemcellpodcast.com to sign up for our e-newsletter and see all the great resources we have there for everyone. What a great ...
Welcome everyone to episode 37! Be sure to go to www.stemcellpodcast.com for previous episodes and to enter your name and email to sign up for our newsletter. On this episode we begin with our signature Science Roundup sponsored by Thermo-Fisher Scientific. In this episode of The Stem Cell Podcast, we discuss papers on a range of topics including making hair from stem cells, a new Parkinson's disease trial, measles on the rise, BPA affects sperm stem cells, too much salt is bad for your brain, and birth controls link to brain cancer. Then we bring on Dr. Christine Mummery to discuss how stem cells are being used for heart disease. We also discuss the new open access journal Stem Cell Reports. After this we finish with a rant about botched weather forecasts.
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
CDC Reports Current Flu Vaccine Effectiveness at 23% This Season – In this article, a report published in the January 16 Morbidity and Mortality Weekly Report (MMWR) estimates that getting a flu vaccine this season reduced a person’s risk of having to go to the doctor because of flu by 23 percent among people of all ages.
India's Tiger Population Sees 30% Increase – According to this article, India says it now has almost a third more tigers than it did four years ago and it was willing to donate tiger cubs to the international community to help conservation efforts.
Scientists Give Genetically Modified Organisms A Safety Switch – In this article, researchers at Harvard and Yale have used some extreme gene-manipulation tools to engineer safety features into designer organisms, specifically reprogrammed the common bacterium E. coli so it requires a synthetic amino acid to live.
WSU Researchers See Effect Of BPA, Estradiol On Sperm Development – This article describes how bisphenol A (BPA) and estradiol contributes to disrupted sperm production resulting in decreased sperm counts.
Too Much Salt Intake Changes Key Brain Circuits – This article shows that excessive salt intake "reprograms" the brain, interfering with a natural safety mechanism that normally prevents the body's arterial blood pressure from rising.
Trust Your Gut: E. Coli May Hold One Of The Keys To Treating Parkinson's – In this article, researchers recently discovered a protein in E. coli that inhibits the accumulation of potentially toxic amyloids—a hallmark of diseases such as Parkinson's.
Hidden Formaldehyde in E-Cigarette Aerosols – This article shows that the carcinogen formaldehyde, a known degradation product of propylene glycol that reacts with propylene glycol and glycerol during vaporization to produce hemiacetals, can be formed during the e-cigarette “vaping” process.
Laser-Generated Surface Structures Create Extremely Water-Repellent Metals – This article describes how scientists at the University of Rochester have used lasers to transform metals into extremely water repellent, or super-hydrophobic, materials without the need for temporary coatings.
Birth Control Pill Risks May Now Include Brain Cancer – In this article, scientists have found that women taking hormonal contraceptives — those containing estrogen, progestin or a combination of both — showed higher rates of a rare brain tumor known as glioma.
Measles Has Infected 84 People In 14 States This Year – According to this article, the Centers for Disease Control and Prevention (CDC) said 84 people in 14 states were diagnosed with measles from Jan.1 through 28, most were infected either at Disneyland or by someone who went there.
Carnegie Mellon, Weizmann Institute Researchers Discover "Idiosyncratic" Brain Patterns in Autism – In this article,
Welcome back for another great episode of the SCP. Be sure to visit www.StemCellPodcast.com and enter your email address in to receive all the show notes and links to all the papers we discuss. We start as always with the science round up brought to you by Thermo Fisher Scientific. In this episode, we discuss the latest and greatest papers ranging from a repurposed over active bladder medication, what stem cell companies to invest in for 2015, a review of the latest iPSC reprograming methods, a new optogenetics study relating to Parkinson’s disease, the sequencing of the oldest mammals genome, and stem cells from the eye to repair damaged corneas. We then talk to Dr. David Piper about disease model tools. Yosif and I then close the show ranting about Parafilm. Enjoy!
Below are all of the papers mentioned on the show. We are working on a way to categorize all of the research papers we mention and possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Resources, Links and Research Papers Mentioned In This Session Include:
Booze Binge Has Immediate Effect On Immune System – According to this article, alcohol can wreak havoc on your immune system from the moment you start imbibing.
BPA Alternative Disrupts Normal Brain-Cell Growth, Is Tied To Hyperactivity, Study Says – In this article, researchers have shown why the chemical bisphenol-S (BPS) once thought to be a safe alternative to bisphenol-A, which was abandoned by manufacturers of baby bottles and sippy cups after a public outcry, might itself be more harmful than BPA.
World First: Scientists Observe DNA Shuttling Between Cells, Triggering Tumor Growth – This article describes how a team of scientists observed that DNA from a mouse's second genome, or mitochondrial DNA, could be transferred from healthy tissue to tumor cells in mice, promoting cancer growth and spread.
Decline In Grants For Young Researchers Puts Future Of Science At Risk, Johns Hopkins President Writes – In this article, the president of John Hopkins University Ronald J. Daniels urges policy reforms and increased National Institutes of Health funding for young scientists who most of them are already leaving the academic biomedical workforce posing a grave risks for the future of science.
Teixobactin: Powerful New Antibiotic Kills Drug-Resistant Bacteria – In this article, a group of researchers led by Prof Kim Lewis of Northeastern University in Boston, Massachusetts, has discovered a new antibiotic Teixobactin that eliminates Methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium tuberculosis, Streptococcus pneumoniae, Bacillus anthracis and other dangerous pathogens without encountering any detectable resistance.
Weight Loss Drug Destroys Fat, Thanks To Bladder Medication: Finally A Treatment For Obesity? – This article describes how researchers figured out how FDA-approved drug mirabegron, typically used to treat overactive bladder, could boost brown fat’s metabolic burning efforts inside the body.
A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging – This article shows how scientists developed a protein scaffold, a repeating peptide array termed SunTag, which can recruit multiple copies of an antibody-fusion protein and may likely have many applications in imaging and controlling biological outputs.
Cold Virus Replicates Better At Cooler Temperatures – According to this article, researchers have found that the common cold virus can reproduce itself more efficiently in the cooler temperature found inside the nose than at core body temperature.
The Challenge Of Creating An HIV Vaccine: Virus Infects Very Cells Induced By Drug – This article tries to explain the reason why there is no vaccine for HIV/AIDS; it is because vaccines designed to protect against HIV backfire, leading to an increase, not decrease,
Happy New Year to all of our Stem Cell Podcast fans! 2014 was a great year and Yosif and I look forward to another great year bringing you the latest and greatest from the world of stem cells and beyond. Just a reminder to visit www.stemcellpodcast.com for all of our episodes and to join our newsletter so we can keep you informed about what is going on with the show. In this show, as always, we start with the science round up brought to you by Thermo Fisher and we discuss the latest hot papers from a wide variety of topics including how cancer might just be bad luck, telomerase inhibition in cancer stem cells a new therapy, making sperm and eggs from stem cells, James Watson selling his Nobel Prize, a new sendai virus for iPSC generation, etc… Then we bring on a post-doctoral fellow from the lab of Michel Sadelain, Dr. Maria Themeli to talk to us about her work using stem cells to create killer T cells to seek and destroy cancer cells...a really cool idea and amazing technology. We finish off the show ranting about iPhone updates.
Below are all of the papers mentioned on the show. Enter in your name and e-mail address below to subscribe to our newsletter, and you will be entered into the monthly Stem Cell Podcast t-shirt drawing.
Resources, Links and Research Papers Mentioned In This Session Include:
Fat Isn't All Bad: Skin Adipocytes Help Protect Against Infections – In this article, researchers report the surprising discovery that fat cells below the skin known as adipocytes help protect us from bacteria.
Researchers Target The Cell’s ‘Biological Clock’ In Promising New Therapy To Kill Cancer Cells, Shrink Tumor Growth – This article tells about the cell biologists at UT Southwestern Medical Center that have targeted telomeres with a small molecule called 6-thiodG that takes advantage of the cell’s “biological clock” to kill cancer cells and shrink tumor growth.
With Cancer, 'Bad Luck' of Random Mutations is Largely to Blame – In this article, scientists have created a statistical model that measures the proportion of cancer incidence, and have found that it's caused mainly by random mutations when stem cells divide.
Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells – According to this article, skin resident macrophages surround and signal to resting hair follicle stem cells (HF-SCs), regulate their entry into a new phase of hair follicle growth.
Methamphetamine Use Linked to Parkinson's Risk – This article reveals that people who use methamphetamine have a greatly increased risk of developing Parkinson's disease and that women who took the drug had higher odds of the disease than men.
Molecular Mechanism Behind Health Benefits Of Dietary Restriction Identified – This article shows the findings from researchers suggesting that hydrogen sulfide (H2S) is one of the key molecules responsible for the benefits of dietary restriction or calorie restriction such as slowing aging and extending lifespan.
Decoding Fat Cells: Discovery May Explain Why We Gain Weight – In this article, researchers discovered that a protein, Thy1, has a fundamental role in controlling whether a primitive cell decides to become a fat cell, making Thy1 a possible therapeutic target for obesity.
Egg And Sperm Race: Scientists Create Precursors To Human Egg And Sperm – According to this article, scientists at the University of Cambridge working with the Weizmann Institute have created primordial germ cells – cells that will go on to become egg and sperm – using human embryonic stem cells.
Billionaire Bought James Watson’s Nobel Prize Medal In Order To Return It – This article talks about Alisher Usmanov, the richest man in Russia and a major shareholder in Arsenal football club who has come forward as the buyer of James Watson’s Nobel Prize medal – declaring that he now plans to give the piece back and the money he spent on the item to be donated to scientific research.
Happy holidays to all of our fans and thanks so much for making The Stem Cell Podcast a success. We hope to make the show better for the 2015 year. Please make sure you go to our website www.stemcellpodcast.com and sign up for our newsletter to get ...
Welcome to Episode 33. Be sure to go to our website www.stemcellpodcast.com to download all of our shows and sign up for our email list. We begin the show with our science roundup brought to you by Thermo Fisher where we discuss a range of new hot pape...
Happy Thanksgiving everyone and thanks for tuning in to Episode 32: Parkinson’s Cell Therapy Featuring Dr. Malin Parmar. Please be sure to go to stemcellpodcast.com and enter your name and email address to win a free SCP t-shirt. As always we start ...
Thanks again for tuning into THE Stem Cell Podcast, we are back with Episode 31. Be sure to go to stemcellpodcast.com and enter your name and email address to receive updates on the show and get entered for a free SCP T-shirt. We begin with our Scien...
Welcome to episode 30, what a great show we have for everyone. As always we dive right into the literature in our science roundup. In the round up we discuss a range of topics including, a paralyzed man walks again, a stem cell box office hit, intestin...
Welcome to episode 29, before we begin the show Yosif and I talk about our new website and all it's cool features. In addition Dr. Chris Fasano was nominated for Stem Cell Person of the Year and everyone needs to go out and vote for him. You can go to stemcellpodcast.com/vote. We then kick off the science round up and review all the latest papers. Dr. Ginger Campbell, host of the brain science podcast, then joins the SCP where we discuss her podcast and different "brainy" topics. We close the show ranting about the iPhone 6. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Near-Death Experiences? Results Of The World's Largest Medical Study Of The Human Mind And Consciousness At Time Of Death
Scientists Warn About Stimulant In Workout Supplements
Tumors Might Grow Faster At Night
Sugar Linked to Memory Problems in Adolescent Rats
Water on Earth Is a Million Years Older Than the Sun
The 2014 Nobel Prizes At A Glance
Making Old Lungs Look Young Again: Animal Research Suggests Ibuprofen Can Reduce Lung Inflammation In Elderly
Judgment And Decision-Making: Brain Activity Indicates There Is More Than Meets The Eye
Peanut Allergy: Could Pulsed Light Remove Allergens From Whole Peanuts?
Grail Visualises Man In The Moon
Satellite Measurements Reveal Gravity Dip From Ice Loss In West Antarctica
Olfactory Dysfunction Predicts 5-Year Mortality in Older Adults
What Weightlifting For Just 20 Minutes Does To Your Brain
New Blood Test Determines Whether You Have Or Are Likely To Get Cancer
Sleep Twitches Light Up The Brain
Cells From Placentas Safe for Patients with Multiple Sclerosis
Alcohol Consumption Influenced By Genes, Research Shows
Turmeric Compound Boosts Regeneration Of Brain Stem Cells
Stem Cell Treatments Surging Into Clinic
First Patient Treated In Neuralstem Phase I Spinal Cord Injury Stem Cell Trial Through The UC San Diego Sanford Stem Cell Clinical Center
Japanese University May Strip Stem-Cell Scientist of Doctorate
Young, Brilliant and Underfunded
Studies Bring Turmeric To Stem Cell Research
Success in Creating Induced Pluripotent Stem Cells
Scientists Develop Barcoding Tools For Stem Cells
Cure For Type 1 Diabetes Imminent After Harvard Stem-Cell Breakthrough
Generation of Functional Human Pancreatic β Cells In Vitro
Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Progenitors via Small-Molecule Activation of WNT Signaling
Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells
We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Photo Reference: Courtesy of Dr. Ginger Campbell
THE Stem Cell Podcast starts off as always with a brief discussion before we dive into the latest science papers of the past two weeks. In our round up we talk about topics ranging from a dinosaur with a huge nose, Alzheimer’s and beta amyloid, a new effective cancer drug, a revised STAP protocol, stem cells to fix your dog, stem cell tourism, amongst others. Then we bring on freelance science writer Karen Weintraub to discuss her recent piece in the New York Times on stem cells. We talk with her about the contents of her article and what she learned doing the research. We then close the show with a rant on automatic car window openers. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Low-Carb Diet Vs. Low-Fat Diet: Why We Should Be More Worried About Reducing Sugar Rather Than Reducing Fat
An Engineered Axl 'Decoy Receptor' Effectively Silences The Gas6-Axl Signaling Axis
Scientists Use Light To Make Mice Asocial
Meet Rhinorex Condrupus: The Nose King. No, Really, The Dinosaur With A HUGE Nose
New Branch Added To European Family Tree: Europeans Descended From At Least 3, Not 2, Groups Of Ancient Humans
Pupil Size Shows Reliability Of Decisions, Before Information On Decision Is Presented
Human Faces Are So Variable Because We Evolved To Look Unique
Gut Microbiota Sways Effectiveness of Flu Vaccine
Monster Black Hole Found In Tiny Galaxy
Gene Described as Critical to Stem Cell Development
Scientists Create Solid Light
Earth's New Address: 'Solar System, Milky Way, Laniakea'
Neuroscientists Identify Key Role Of Language Gene
Schizophrenia Not A Single Disease But Multiple Genetically Distinct Disorders
Italian Scientist Says G-Spot Doesn't Exist: 'CUV Region,' New Erogenous Zone, May Hold Key To Female Orgasm
Ancient Flying Reptile Resembled Ikran From Avatar Movie
You Can Classify Words In Your Sleep
Researchers Find Neural Compensation In People With Alzheimer’s-Related Protein
Antibiotics Found In Human Body Bacteria
Study Links Honesty To Prefrontal Region Of The Brain
A New Cancer Drug Worked In Over 25% Of Patients. What Does That Mean?
NUS Study Shows Effectiveness Of Artesunate, A Common Herbal-Based Anti-Malarial Drug, In Controlling Asthma
Artificial Sweeteners Induce Glucose Intolerance By Altering The Gut Microbiota
STAP Co-Author Offers Yet Another Recipe For Stem Cells
Stem Cell Therapy For Pets Available In Huntsville
Stem Cell Tourism and Patient Education
Professional Regulation: A Potentially Valuable Tool in Responding to “Stem Cell Tourism”
Scientists Identify Key Factor That Maintains Stem Cell Identity
Researchers Use Ips Cells To Show Statin Effects On Diseased Bone
Pluripotent Stem Cells Derived From Mouse Primordial Germ Cells By Small Molecule Compounds
Proteomics and Glycoproteomics of Pluripotent Stem-Cell Surface Proteins
Hebrew University Scientists Create Therapy-Quality Stem Cells Using New Cocktail To Reprogram Adult Cells
Reversal of Cellular Phenotypes in Neural Cells Derived from Huntington’s Disease Monkey-Induced Pluripotent Stem Cells
Stem Cell Transplant Does Not Cure SHIV/AIDS After Irradiation Of Infected Rhesus Macaques
Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis
Cord Blood Expansion. Pyrimidoindole Derivatives Are Agonists Of Human Hematopoietic Stem Cell Self-Renewal.
We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
PhotoReference: Courtesy of Karen Weintraub
The SCP is back with episode 27 just in time for the fall season. We begin as always with the roundup where we review the recent literature on a wide variety of topics. Some of them include a new study on “blank state” stem cells, the first iPSC cell replacement therapy, a copy of the STAP reviewer comments was released, marijuana and Alzheimer's, a possible new therapy for hair loss, and a new way to make insulin producing cells fro diabetes patients. We then bring on Dr. Valentina Fossati from the New York Stem Cell Foundation, to talk about her recent publication using iPSCs to generate the oligodendrocytes, the cells that myelinate neurons and its implications for multiple sclerosis. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Vaccines—Calling the Shots
Blood Group 'Link To Memory Loss'
Textbooks May be Wrong About Volcanoes
UV Light Can Turn Gene Into Source Of Skin Cancers, Researchers Find
UCLA Biologists Delay The Aging Process By ‘Remote Control’
Eating Habits, Body Fat Related To Differences In Brain Chemistry
Can Sleep Loss Affect Your Brain Size?
Neanderthal 'Art' Created 40,000 Years Ago, Found In Gibraltar Cave
Composition of Earth’s mantle revisited thanks to research at Argonne’s Advanced Photon Source
Marijuana Compound May Offer Treatment For Alzheimer’s Disease, USF Preclinical Study Finds
Neuroscientists Reverse Memories’ Emotional Associations
Scripps Research Institute Scientists Link Alcohol-Dependence Gene to Neurotransmitter
Estrogens Stimulate Serotonin Neurons To Inhibit Binge-Like Eating In Mice
Physically Fit Kids Have Beefier Brain White Matter Than Their Less-Fit Peers
Sexually Dimorphic RB Inactivation Underlies Mesenchymal Glioblastoma Prevalence In Males
FDA-Approved Drug Restores Hair in Patients with Alopecia Areata
Obituary: Yoshiki Sasai 1962–2014
Nature Reviewers Not Persuaded By Initial STAP Stem Cell Papers
Japan Carries Out First Ips Stem Cell Implant Surgery
Scientists ‘Reset’ Human Stem Cells To ‘Blank State’ (Austin Smith)
Diabetes Researchers Find Faster Way To Create Insulin-Producing Cells
Stem Cell Research Offers Clues About Schizophrenia
The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection
Conversion of Human Fibroblasts into Monocyte-Like Progenitor Cells
Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation
Chemical Conversion of Human Fibroblasts into Functional Schwann Cells
Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells
We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
PhotoReference: Courtesy of Dr. Valentina Fossati
THE SCP landed another big fish for this episode, Dr. Austin Smith of Cambridge UK. In the second half of the show we interview Dr. Smith and get his take on the world of all things pluripotency. We talk about his views on the ground state of pluripotency and how he attempted to drill down into the essential components of the pluripotency network using computer modeling. Before we get there, as always Yosif and I update you on the latest news with our round ups, talking about a range of topics from using stem cells to create a thymus, stem cells to cure stiff person syndrome, humans develop more like lizards than other mammals, methane gas from sea floor, Riken study to verify STAP fails, and a bunch more. Then we close with a rant about bogus science conferences.
Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Gut Bacteria That Protect Against Food Allergies Identified
A Long Childhood Feeds the Hungry Human Brain
First Intact Organ Built From Cells
Clear Solar Panel Could Turn Smartphones And Tablets Into Mini Power Plants, Michigan Researchers Say
Methane Is Bubbling Up From Hundreds of Places Along the U.S. East Coast Seafloor
Plant Development. Arabidopsis NAC45/86 Direct Sieve Element Morphogenesis Culminating In Enucleation.
Ohio Catholic Diocese Discourages ALS Ice Bucket Challenge
Children with Autism Have Extra Synapses in Brain
Transcriptomic Analysis of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of Conserved Vertebrate Developmental and Repair Mechanisms
Traces of One of Universe's First Stars Detected
Cold, Dark and Alive! Life Discovered in Buried Antarctic Lake
This Could Explain Why Older Adults Can’t Stay Sleep
Biological Pacemaker Created By Minimally Invasive Somatic Reprogramming In Pigs With Complete Heart Block
Injected Bacteria Shrink Tumors in Rats, Dogs and Humans
Catholic Church Warns Pro-Lifers About Ice Bucket Challenge Donations
In Japan, Official Effort To Replicate STAP Stem Cells Comes Up Empty
Canadian Doctors Use Stem Cells To Treat 'Stiff Person Syndrome'
Stem Cell Trial For Spinal Cord Injuries Cleared By FDA
Rogue Stem Cell Therapy Operators Charging Thousands For Ineffective Treatments, Researchers Say
Boron Facilitates Stem Cell Growth And Development In Corn
Scientists Successfully Grow New Thymus From Stem Cells
Systematic Identification Of Culture Conditions For Induction And Maintenance Of Naive Human Pluripotency
Generation Of Multipotent Induced Neural Crest By Direct Reprogramming Of Human Postnatal Fibroblasts With A Single Transcription Factor
Targeting Self-Renewal In High-Grade Brain Tumors Leads To Loss Of Brain Tumor Stem Cells And Prolonged Survival
We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Photo Reference: Courtesy of Dr. Austin Smith
The Stem Cell Podcast is so excited to bring you our 25th episode. Thanks to all of our listeners for making the show a success. We begin the show like always recapping the latest science news including topics ranging from more fraud regarding publications, what the heck does the impact factor mean, development of an anti-HIV tampon, novel stem cell discovery using zebrafish, Dr. Vacanti to step down, and a possible lipofectamine alternative. Then we bring on Dr. Paul Knoepfler to recap the STAP cell story in the light of the tragic death of Dr. Yoshiki Sasai. We discuss this and a wide variety of topics related to publishing in science with Dr. Knoepfler. We then close the show with a rant on depression and its acceptance in the US.
ENJOY!
Resources, Links and Research Papers Mentioned In This Session Include:
Thousand-Strong Robot Swarm Throws Shapes, Slowly
SAGE Publications Busts “Peer Review And Citation Ring,” 60 Papers Retracted
Could A Dissolvable, Drug-Loaded Tampon Protect Against HIV?
Why Living in the Moment Is Impossible
Our Brains Judge a Face’s Trustworthiness – Even When We Can’t See It
Growing Human GI Cells May Lead To Personalized Treatments
The Alzheimer's Cure That Worked on Mice
Clues To Curbing Obesity Found In Neuronal ‘Sweet Spot’
Breast Cancer's BRCA1 And BRCA2 Not The Only Gene Mutations To Worry About: Who Should Care About PALB2
Stanford Scientists Create Remote-Controlled Nanoscale Protein Motors
Stanford Bioengineering Team Builds Molecular Motors
Pepper and Halt: Spicy Chemical May Inhibit Gut Tumors
Study Of Twins Discovers Gene Mutation Linked To Short Sleep Duration
Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks
Otzi Iceman Had Genetic Predisposition For Atherosclerosis: Much The Same In Ancient Peoples As It Is Today
Potential 'Universal' Blood Test For Cancer Discovered
Japanese Researcher, an Author of a Discredited Stem Cell Study, Is Dead
Brigham Researcher In Flawed Stem Cell Study Will Step Down
Transparency Promised For Vilified Impact Factor
A Stem Cell Study Shows Promising Results For Severe Stroke Patients
Stem Cell Research Gets Huge Boost From Australian Zebrafish Discovery
Stem Cells Reveal How Illness-Linked Genetic Variation Affects Neurons
A Simple And Efficient Method For Transfecting Mouse Embryonic Stem Cells Using Polyethylenimine
Seamless Gene Correction Of Beta-Thalassemia Mutations In Patient-Specific Cells
Effect of Human Donor Cell Source on Differentiation and Function of Cardiac Induced Pluripotent Stem Cells
Generation of Rat-Induced Pluripotent Stem Cells from a New Model of Metabolic Syndrome
We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Photo Reference: Courtesy of Dr. Paul Knoepfler
Episode 24 begins as usual with the science round up and where we discuss a range of topics including babies learn fear from distressed moms, spider silk for stem cells, making sugars for stem cell differentiation, Stem Cells Inc in hot water, and Schizophrenic patients lose brain volume. We then bring on the show Dr. Marco Seandel from Weill Cornell Medical College to talk about his latest paper published in Stem Cell Reports, where they use sperm stem cells to uncover novel info about mutations in aged male sperm. We then rant about post-doctoral salaries. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Learning The Smell Of Fear: Mothers Teach Babies Their Own Fears Via Odor, Animal Study Shows
The Habenula Encodes Negative Motivational Value Associated With Primary Punishment In Humans
A Highly Abundant Bacteriophage Discovered In The Unknown Sequences Of Human Faecal Metagenomes
Mysterious X-rays Might Hint at Dark Matter
Researchers Find First Sign That Tyrannosaurs Hunted In Packs
The Black Death in China
Longitudinal Changes in Total Brain Volume in Schizophrenia: Relation to Symptom Severity, Cognition and Antipsychotic Medication
Junk Food Could Destroy Your Sense Of SMELL, Scientists Warn
Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis
Genetic Cause Of Common Breast Tumors Found
Lawsuit Claims Stem Cells Unsafe
California's Stem Cell Scandal Gets Worse
Sugar Mimic Helps Embryonic Stem Cells Develop Toward Nerve Cells
Teeth Sprout from Glia-Derived Stem Cells
Stem Cell Research Could Lead To New Muscle Repair Treatments
Stem Cell Therapy Could Lead To HIV Cure
Functional And Molecular Defects Of Hipsc-Derived Neurons From Patients With ATM Deficiency
Spider Silk For Xeno-Free Long-Term Self-Renewal And Differentiation Of Human Pluripotent Stem Cells
Role Of Astroglia In Down’s Syndrome Revealed By Patient-Derived Human-Induced Pluripotent Stem Cells
Generation Of Induced Pluripotent Stem Cells From Virus Freein Vivo Reprogramming Of BALB/C Mouse Liver Cells
Gene Expression Variability as a Unifying Element of the PluripotencyNetwork
Enhanced Fitness of Adult Spermatogonial Stem Cells Bearing a Paternal Age-Associated FGFR2 Mutation
We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries. Enter in your name and e-mail address below, and we will notify you of when this feature is available.
Photo Reference: Courtesy of Dr. Marco Seandel
Episode 23, we kick it off with the science round up and talk about papers covering all topics from good friends genetically looking like blood relatives, ebola outbreaks, in vivo reprogramming to restore function after hear attack to converting pluripotent stem cells to blood stem cells. We then bring back to the show Dr. Daylon James to talk about a new paper in nature where they use a vascular niche to help instruct and reprogram endothelial cells to blood stem cells. We then rant about umbrellas. Yes, you read correctly, umbrellas.
Resources, Links and Research Papers Mentioned In This Session Include:
WHO: Ebola Outbreak Deaths in West Africa hit 603
Friends Are the Family You Choose: Genome-Wide Analysis Reveals Genetic Similarities Among Friends
Oldest Case of Down Syndrome Discovered in 1,500-Year-Old Skeleton
Cracking The Code Of How The Brain Processes Emotions
What Causes Autism? Rare Mutation In The CHD8 Gene May Be Responsible For Autism Subtype
New Alzheimer’s Test May Help Future Clinical Trials
Coffee Reduces The Risk of Parkinson's Disease
‘Asian Flush’ Signals Drinkers To Ease Up On Alcohol
Pelagornis sandersi: Paleontologist Discovers Largest-Ever Flying Bird
Consciousness On-Off Switch Discovered Deep In Brain
EU Court Adviser Backs Stem Cell Patenting
Large Study of Stem Cells for Autism Draws Criticism
Experimental Stem Cell Treatment Causes Woman To Grow Parts Of A Nose On Her Spine
Ground-Breaking Stem Cell Technique Developed To Heal Fractures And Prevent Amputations
Gene Profiling Technique to Accelerate Stem Cell Therapies for Eye Diseases
A Method To Recapitulate Early Embryonic Spatial Patterning In Human Embryonic Stem Cells
Biological Pacemaker Created By Minimally Invasive Somatic Reprogramming In Pigs With Complete Heart Block
Direct Induction Of Haematoendothelial Programs In Human Pluripotent Stem Cells By Transcriptional Regulators
Reprogramming Human Endothelial Cells To Haematopoietic Cells Requires Vascular Induction
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Photo Reference: Courtesy of Dr. Daylon James
We hope everyone had an awesome 4th of July, we are back with Episode 22 and dive right in with our literature review. On this show we discuss everything from freezing down testicles, to retinas that sense light from stem cells, and we salute good riddance to STAP cells. We close referencing new paper in Cell Stem Cell, and bring on the senior author Dr. Paul Tesar from Case Western Reserve to talk about the paper and his work. After the interview we all rant about people presenting only published data at conferences. Enjoy and as always please leave us your feedback.
Resources, Links and Research Papers Mentioned In This Session Include:
Bone Marrow Transplant Could Reverse Sickle Cell In Adults
Freezing Testicle Tissue In Mice Offers Fertility Hope For Cancer Survivors
Alzheimer's Linked To Brain Hyperactivity
Obesity Linked To Type 2 Diabetes By An Absent Protein
New Diabetes Drug Could Retrain GI Cells To Produce Insulin By Switching Off One Gene
Not All Stem Cells Created Equal
STAP Retracted
Supermassive Black Hole Obscures Heart of Galaxy with 'Rare and Powerful Stream of Gas'
Virus Kills Triple Negative Breast Cancer Cells, Tumor Cells In Mice
Torsina Hypofunction Causes Abnormal Twisting Movements And Sensorimotor Circuit Neurodegeneration
Destroying Bacterial Cell Walls May End Antibiotic Resistance Forever
If Blocked Endocannabinoids Trigger Dementia Symptoms, Could Cannabis Prevent Alzheimer’s?
Minimal Toolkit for Stem Cell Self-Renewal
Dinosaurs Were Mesothermic Beasts, Neither Warm-Blooded Nor Cold-Blooded
Geron hESC Trial to Resume?
Stem Cells Form Light-Sensitive 3-D Retinal Tissue
Delivering Capsules Of Stem Cells Helps Repair Injured Bones
Study Identifies Link Between Gut Bacteria Post SCT Survival
Cancer May Never Be Completely Eradicated: Study
Stem Cells Slow Retinal Degeneration in Dry AMD Clinical Trial
Sustained ERK Activation Underlies Reprogramming in Regeneration-Competent Salamander Cells and Distinguishes Them from Their Mammalian Counterparts
Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis
An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells
Epigenomic Comparison Reveals Activation of “Seed” Enhancers during Transition from Naive to Primed Pluripotency
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Photo Reference: Courtesy of Dr. Paul Tesar
This is a special episode consisting of over 75 minutes of live interviews. Last week THE Stem Cell Podcast attended the International Society for Stem Cell Research meeting and pulled people aside to get there take on the meeting and stem cell research. We compiled all the interviews into one show for you to enjoy. We interview a wide range of people for some very broad talking points. Hope you enjoy.
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Wow, our 20th show already, we can't believe it! In this episode we start by talking about the upcoming ISSCR meeting in Vancouver. The Stem Cell Podcast will be there at a booth doing live interviews, come on by. We then move into the science roundup and discuss a wide variety of topics such as using stem cells to model viral-host interaction, activating tooth stem cells with lasers, the loss of pain sensors leading to longer lives, more on the STAP story, green tea protecting you from cancer, and how a gene mutation in hair stem cells causes blonde hair. After that we bring on Dr. Dieter Egli from the New York Stem Cell Foundation (NYSCF) to talk about his work in using SCNT to derive new embryonic stem cell lines. We discuss his previous and current work, including his latest story just published in Nature last month. We close the show with a rant on an opinion piece where they proposed to eliminate graduate students by taking stipends away. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Sensing Of Amino Acids In A Dopaminergic Circuitry Promotes Rejection Of An Incomplete Diet In Drosophila
Histone Modifications Are Associated With Delta(9)-Tetrahydrocannabinol-Mediated Alterations In Antigen-Specific T Cell Responses
Compound In Saliva Helps Protect Our Cells From Toxins In Coffee, Tea, Study Shows
A Molecular Basis For Classic Blond Hair Color In Europeans
Engineering a memory with LTD and LTP
Green Tea Component Upsets Cancer Cell Metabolism
Photoactivation of Endogenous Latent Transforming Growth Factor–β1 Directs Dental Stem Cell Differentiation for Regeneration
Targeting CXCL12 From FAP-Expressing Carcinoma-Associated Fibroblasts Synergizes With Anti–PD-L1 Immunotherapy In Pancreatic Cancer
Fighting Back: Patient's Own Immune Cells Tackle Cervical Cancer
A Draft Map Of The Human Proteome
Abnormal Neuronal Differentiation And Mitochondrial Dysfunction In Hair Follicle-Derived Induced Pluripotent Stem Cells Of Schizophrenia Patients
Role of the Primate Ventral Tegmental Area in Reinforcement and Motivation
Tai Chi Intervention Increases Progenitor CD34(+) Cells in Young Adults
Unconditional Quantum Teleportation Between Distant Solid-State Quantum Bits
Remission of Disseminated Cancer After Systemic Oncolytic Virotherapy
Less Pain (Receptors) Means a Longer Life
Mice With Mohawks Reveal Two Biological Pathways Linked With Autism Behaviors
CC Sabathia Ready To Throw For First Time Since Stem-Cell Treatment For Knee
New Record Highs In Moral Acceptability - Premarital Sex, Embryonic Stem Cell Research, Euthanasia Growing In Acceptance
The Broad Foundation Advances Stem Cell Research At USC
Obokata Agrees To STAP Experiment
Inside a Corrupt Stem Cell Research Lab
EU Commission Rejects Petition To Stop Funding Embryonic Stem Cell Research
Blonde Is Just A Matter Of A Tiny Stem Cell Molecule Tweak, Says New Research
Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-Derived Hepatocytes
The Age And Genomic Integrity Of Neurons After Cortical Stroke In Humans
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Photo Reference: Courtesy of Dr. Dieter Egli
On this episode we review the Next Gen Stem Cell Conference from earlier in the month. During the conference we interviewed 5 stem cell scientists live and put them all together for this show. In addition to these great guests, we review the literature as always. Topics include the biggest sperm ever, C-kit+ stem cells don't make heart, heart on a chip technology, a new element on the periodic table, and iPSCs from schizophrenia patients. After that, we end with a rant about bathroom air fresheners!
Resources, Links and Research Papers Mentioned In This Session Include:
World's Oldest Sperm Discovered: 17-Million-Year-Old Cell Is Longer Than Its Creator
Researchers Identify Link Between Colon Cancer And Metabolism
In Vivo Modulation Of Hypoxia-Inducible Signaling By Topographical Helix Mimetics.
Heart Cells Have 'Preteen' Growth Spurt
An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice
New Super-Heavy Element 117 Confirmed By Scientists
Autism-Related Protein Shown to Play Vital Role in Addiction
Chd5 Orchestrates Chromatin Remodelling During Sperm Development
‘Heart Disease-On-A-Chip’
Syphilis Made A Big Comeback In 2013, CDC Warns
Life Extension Factor Klotho Enhances Cognition
Meet HD 162826, The Sister Star Of Our Sun
Novel Antioxidant Makes Old Arteries Seem Young Again, Study Shows
Scripps Research Institute Scientists Create First Living Organism that Transmits Added Letters in DNA 'Alphabet'
Model Universe Recreates Evolution Of The Cosmos
Long-Snouted Tyrannosaur Unearthed
Vampire's Delight? Young Blood Recharges Brains of Old
Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules
Hope For Aging Brains, Skeletal Muscle
Stem Cell Therapy Saves Eyesight Of Fountain Valley Mother
c-kit+ Cells Minimally Contribute Cardiomyocytes To The Heart
Study Questions Use Of Stem Cells To Repair Heart
Modeling The Mitochondrial Cardiomyopathy Of Barth Syndrome With Induced Pluripotent Stem Cell And Heart-On-Chip Technologies
Phenotypic Differences In Hipsc Npcs Derived From Patients With Schizophrenia.
Recombinase-Mediated Reprogramming and Dystrophin Gene Addition in mdx Mouse Induced Pluripotent Stem Cells
U.S. Biomedical Research 'Unsustainable,' Prominent Researchers Warn
Rescuing US Biomedical Research From Its Systemic Flaws
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We are back for episode 18. On this show we review the literature and talk about a range if topics including stem cells injected into hearts, mice afraid of male researchers, diabetic SCNT, and the staircase of shame. We then bring Dr. Kevin Eggan from Harvard University on the show to talk about his latest work using stem cells to cure ALS/Lou Gehrig's disease. Enjoy.
Resources, Links and Research Papers Mentioned In This Session Include:
Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules
Hope For Aging Brains, Skeletal Muscle
Pain Curbs Sex Drive In Female Mice, But Not In Males
New Virus Related To Smallpox Is Found In Republic Of Georgia
Male Researchers Stress Out Rodents
Scripps Florida Scientists Find Connection Between Gene Mutation, Key Symptoms of Autism
Soy-Dairy Protein Blend and Whey Protein Ingestion After Resistance Exercise Increases Amino Acid Transport and Transporter Expression in Human Skeletal Muscle
Push Comes To Shove: Gilead's $1,000 Pill Could Hurt Insurer Earnings
Death Rates From Pancreatic Cancer Predicted To Rise In Europe In 2014
Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function
Y chromosome is Not Disappearing, Researchers Say
Loss Of Memory Reversed In Alzheimer's Mice Models
MRSA Spreads In Households
REDD1 Is Essential For Stress-Induced Synaptic Loss And Depressive Behavior
Amyloid Precursor Protein Regulates Neurogenesis By Antagonizing Mir-574-5p In The Developing Cerebral Cortex
Japanese Nobel Winner Latest to Apologize Over Stem-Cell Research
RIKEN to Check 20,000 Papers for Doctored Images and Plagiarism
Stem Cells and the "Staircase of Shame"
Stem Cells May Be Key to Long Life: Research on Body of 115-Year-Old Woman
How Silly Putty may advance stem cell research
First Stem Cells Cloned From Diabetes Patient, Thanks to Egg Donors
Human Oocytes Reprogram Adult Somatic Nuclei Of A Type 1 Diabetic To Diploid Pluripotent Stem Cells
Human Embryonic-Stem-Cell-Derived Cardiomyocytes Regenerate Non-Human Primate Hearts
Infertility: Stem Cell-Based Sperm Created From Infertile Mens Skin
Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors
A 3D Sphere Culture System Containing Functional Polymers for Large-Scale Human Pluripotent Stem Cell Production
3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
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Photo Reference: Courtesy of Dr. Kevin Eggan
Yes you read it right, Naked Stem Cells. On this episode we talk with the creator and host of The Naked Scientists; a website and podcast dedicated to all things science. We talk with Chris about his shows, and get his take on the stem cell field. As always we highlight the literature over the past few weeks talking about everything from the STAP drama, SCNT, stem cells to make new noses, how weed changes your brain, and cave insects with mixed up genitalia. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
House Windows That Double As Solar Panels? Shiny Quantum Dots Brighten Future Of Solar Cells
Is Parkinson's An Autoimmune Disease?
KOI-3278: A Self-Lensing Binary Star System
Scientists Spot A Planet That Looks Like 'Earth's Cousin'
Female ‘Penis’ Found on Brazilian Cave Insects
Oh Baby: Scientists Find Protein That Lets Egg And Sperm Hook Up
Is 'Sluggish Cognitive Tempo' a New Disorder or an Extension of ADHD?
Artificial Blood on an Industrial Scale
Mapping Gene Expression in the Fetal Brain
Casual Marijuana Use Linked To Brain Changes, Researchers Say
Gene Variant Puts Women At Higher Risk Of Alzheimer’s Than It Does Men, Study Finds
Traces of Trauma in Sperm RNA
Lab-Grown Private Parts: Vagina Implants Cure Rare Disorder
Gut-Eating Amoeba Caught On Film
Gene Therapy Successfully Regenerates An Old Organ Inside A Living Animal
Bees Exposed to Fungicide More Vulnerable to Nosema Parasite
Obokata Mentor, Co-Author: STAP Cells Just A ‘Hypothesis’
In Stem-Cell Research, Health Benefits Outweigh The Risks Of Copying Humans
Human Somatic Cell Nuclear Transfer Using Adult Cells
Organs Created From Stem Cells For Transplantation
Conversion of Quiescent Niche Cells to Somatic Stem Cells Causes Ectopic Niche Formation in the Drosophila Testis
Auxetic Nuclei In Embryonic Stem Cells Exiting Pluripotency
Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1
Multifaceted Regulation of Somatic Cell Reprogramming by mRNA Translational Control
Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming
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Photo Reference: Courtesy of Dr. Chris Smith - The Naked Scientists
Welcome back for another episode. We start off looking at the papers published over the past few weeks. We discuss everything from stem cells for ALS, pluripotency viruses, and what the brain looks like during an orgasm. We then bring on Dr. Raja Kittappa, a stem cell scientist who has recently decided to leave science and run for congress. Finally Raj and Yosif tell some funny stories about their time spent in Europe. To find out more information on how you can help Raj get to congress and fight for the scientists, visit his website: http://www.rajforcongress2014.com/ Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Brain Activation during Human Male Ejaculation
Experimental Cancer Drug Reverses Schizophrenia In Adolescent Mice, Johns Hopkins University Study
First Synthetic Yeast Chromosome Revealed
Party Drug Ketamine Could Help People With Severe Depression, University of Oxford Study
Experimental Compound FRAX486 Reverses Signs Of Fragile X In Mice
Researchers Identify Good Bacteria That Protects Against HIV
MIT Researchers Develop Living Material Using E. coli
Disorganized Cortical Patches Suggest Prenatal Origin of Autism
Blood Test of 4 Biomarkers Predicts Death Within 5 Years
Gene Family Linked To Brain Evolution Implicated In Severity Of Autism Symptoms
HPV-Linked Throat Cancer May Have Telltale First Symptoms
Mugshots built from DNA data
Genetic Factor Contributes To Forgetfulness
Study: Climate Change Accelerates Greenland Ice Loss
Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
Human Nose Can Detect More Than 1 Trillion Smells, Scientists Discover
Scientists Find Gene Which Is Linked To Exceptionally Low IQ In Children
Stem Cell Scientist Guilty Of Falsifying Data
Ancient Virus DNA Gives Stem Cells the Power to Transform
Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons
Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons
Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging
Mouse SCNT ESCs Have Lower Somatic Mutation Load Than Syngeneic iPSCs
Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study
Combined Hydrogels That Switch Human Pluripotent Stem Cells From Self-Renewal To Differentiation
Mutations in USP9X Are Associated with X-Linked Intellectual Disability and Disrupt Neuronal Cell Migration and Growth
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Photo Reference: Courtesy of Dr. Raja Kittappa
In this episode we review the literature from the past two weeks including a novel blood test for Alzheimer's disease, an Anti-HIV gel, iPSCs and ring chromosomes and the generation of haploid stem cells. We then bring on an internationally recognized stem cell and cancer researcher Dr. Leonard Zon from Harvard Medical School and Boston Children's Hosital. Dr. Zon talks to us about his work using zebrafish as a model to study cancer and melanoma and tells some really funny stories on his experiences with these fish. We close the show with a rant on laboratory sabotage. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Trends In Atmospheric Carbon Dioxide In Mauna Loa, Hawaii
Gel Protects Monkeys From H.I.V. After Sex, Study Finds
Genetic Modification And Screening In Rat Using Haploid Embryonic Stem Cells
Telescope Captures View Of Gravitational Waves
Structures Of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Environmental And State-Level Regulatory Factors Affect The Incidence Of Autism And Intellectual Disability
Respiratory Failure, Cleft Palate And Epilepsy In The Mouse Model Of Human Xq22.1 Deletion Syndrome
CDC Warns Untreatable Gonorrhea Could Spread Like Wildfire
In Rare Case, Woman With H.I.V. Infects Female Sex Partner, C.D.C. Says
Obesity-Associated Variants Within FTO Form Long-Range Functional Connections With IRX3
Hydrous Mantle Transition Zone Indicated By Ringwoodite Included Within Diamond
Human C-Tactile Afferents Are Tuned To The Temperature Of A Skin-Stroking Caress
Shorter Telomeres With High Telomerase Activity Are Associated With Raised Allostatic Load And Impoverished Psychosocial Resources
Biomarkers Could Predict Alzheimer's Before It Starts
Confusions About Totipotency: Stem Cells Are Not Embryos
Mechanical Memory And Dosing Influence Stem Cell Fate
Cell-Autonomous Correction Of Ring Chromosomes In Human Induced Pluripotent Stem Cells
C9orf72 Nucleotide Repeat Structures Initiate Molecular Cascades Of Disease
Haematopoietic Stem Cells Require A Highly Regulated Protein Synthesis Rate
High-Efficiency Motor Neuron Differentiation From Human Pluripotent Stem Cells And The Function Ofislet-1
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Photo Reference: Courtesy of Dr. Leonard Zon
Over the past few weeks some really exciting papers came out describing the reprogramming of one cell into another, a process called Direct Reprogramming. On this episode we talk with Dr. Justin Ichida from USC who uses the latest reprogramming techniques in his lab to study neural disease. We review the literature from the past two weeks including increased brain activity in those that recall their dreams, incidence of Autism on the rise, converting skin cells into liver or pancreatic cells, and making meat from celebrities. We close with a rant on stir bars. Enjoy!
Justin Ichida completed his Ph.D. at Harvard Medical School in the laboratory of Dr. Jack Szostak. From 2007-2012, he was a postdoctoral fellow in the laboratory of Dr. Kevin Eggan in the Department of Stem Cell and Regenerative Biology at Harvard University. Dr. Ichida was a New York Stem Cell Foundation Druckenmiller Fellow and a recipient of the NIH K99/R00 Pathway to Independence award from the National Institute of Neurological Disorders and Stroke. Since 2013, he has been an Assistant Professor of Stem Cell Biology and Regenerative Medicine at the University of Southern California. His current research is focused on using patient-specific disease models to define the mechanisms that lead to neuronal loss in ALS and frontotemporal dementia.
Resources, Links and Research Papers Mentioned In This Session Include:
University of Southern California - The Ichida Lab – Board California Institute for Regenerative Medicine (CIRM) Center for Regenerative Medicine and Stem Cell Research
Research Papers:
Early Treatment Is Found to Clear H.I.V. in a 2nd Baby
Why Can You Remember Your Dreams? Researchers Uncover Why Only Some People Can Recall Them In The Morning
Acetaminophen In Pregnancy Linked To ADHD In Kids, Study Finds
Is It The Gluten Or Is It The Glyphosate?
Study Uncovers New Pathway Of Melanoma Metastasis
New Research Finds Direct Connection Between Acupuncture And Processes That Alleviate Sepsis
Largest Ever' Trial Of Adult Stem Cells In Heart Attack Patients Begins
This Company Wants To Make In-Vitro Meat From Celebrities’ Stem Cells
USPTO Issues Patent For Fraudulent Stem Cell Procedure
Isolation Of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors By Cell Sorting For Successful Transplantation
Coordination Of Engineered Factors With TET1/2 Promotes Early-Stage Epigenetic Modification During Somatic Cell Reprogramming
Small Molecules Facilitate the Reprogramming of Mouse Fibroblasts into Pancreatic Lineages
Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes
Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming
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Photo Reference: Courtesy of Dr. Justin Ichida
STAP stem cells were a new method of generating pluripotent stem cells published in a paper a few weeks ago. When it came out, scientists scratched their heads and wondered whether or not this new method could actually work and be reproducible. Well, while the jury is still out, it is not looking good and we bring on the show one of the most recognized voices of stem cell research, Dr. Paul Knoepfler to discuss the STAP stem cell theory. In addition to running a laboratory, Dr. Knoepfler maintains an amazingly active stem cell blog breaking all the latest stem cell news, and educating the public about stem cells.
As always, we update you on the current industry literature including a new method to make platelets, how to make old muscles young, the role of NANOG in reprograming, and the discovery of a new protein involved in brain formation.
To close it out, we finish up with a rant on two different topics. Yeah that’s right, a two for one rant. Enjoy!
Resources, Links and Research Papers Mentioned In This Session Include:
Knoepfler Lab Stem Cell Blog
Stem Cells: An Insiders Guide by Paul Knoepfler
Research Papers:
Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells
The endocannabinoid system controls food intake via olfactory processes
Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Nanog-Independent Reprogramming to iPSCs with Canonical Factors
Nanog Is Dispensable for the Generation of Induced Pluripotent Stem Cells
In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model
NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells
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Photo Reference: Courtesy of Dr. Paul Knoepfler
In this episode we touch on the topic of cancer and how stem cells are relevant for disease progression and potential therapeutics. In the science roundup we cover zombie bees, stem cells for baldness, dipping cells in acid to make stem cells, and how to identify the difference between iPSCs and hESCs.
We then interview another stem cell pioneer, Dr. Sean Morrison, who is internationally recognized for his work in understanding the mechanisms of stem cell regulatory mechanisms and how this is relevant in cancer. Then of course, we finish up with a signature SCP rant. Enjoy!
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Photo Reference: Courtesy of Dr. Sean Morrison
THE Stem Cell Podcast still going strong with episode 11. We start off the show inviting everyone to this year's NextGen Stem Cell Conference where stem cell scientists will come together for a causal, fun meeting of the minds.
We then go through the science roundup discussing everything from a new herpes drug, to heart cell propelled sperm looking bio-bots, to stem cell-derived 3D kidneys.We then talk to Dr. Mark Tomishima, director of the SKI Stem Cell Research Facility located in New York City. Mark tells us about what his and other core facilities do for stem cell researchers locally and abroad, as well as various projects his group is working on. Dr. Tomishima is a true stem cell guru with tons of knowledge, and of course, some really funny stories about Yosif. Enjoy!
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Photo Reference: Courtesy of Dr. Mark Tomishima
Wow, 10 episodes already! We made the 10th one extra special. In the science roundup we talk about everything from caffeine boosting memory, to the possibility of the Y chromosome disappearing.
We then bring on a true pioneer in the stem cell field, Dr. Sally Temple, scientific director of the Neural Stem Cell Institute. Dr. Temple discovered that stem-like cells exist in the adult brain in the late 80s and has since gone on to characterize these cells extensively. Her group has recently discovered a novel stem cell in the eye that they plan to use as a new therapy for macular degeneration, the leading cause of blindness. A great listen, very informative, and of course we end with a good stem cell rant. Enjoy!
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Photo Reference: Courtesy of Dr. Sally Temple
Happy new year Stem Cell Podcast listeners, we are back to start off with an episode that looks backs at a year of science in 2013 and gives you our top 10 studies from both the stem cell world and science as a whole. Everything from human cloning to going interstellar. It's been a great year for science despite threats to funding. Let's make sure science funding increases in 2014. Enjoy!
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In this episode we start with our science round up discussing everything from the ground state in stem cells to male birth control. We then dive into other stem cell topics including reprogramming via protein transduction and CRISPR-mediated gene repair.
In the final part of the show we interview Justine Miller, a PhD candidate from Lorenz Studer's lab at Memorial Sloan Kettering to discuss their recent paper in Cell Stem Cell showing how to age stem cell-derived neurons in the culture dish. We then finish off the show with some True/False questions. Enjoy!
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Photo Reference: Courtesy of Justine Miller, PhD candidate
We are back with a stem cell "quickie" for the holidays. In our science round up we talk mummified ribs, fear of snakes, and genes associated with an increased risk of Alzheimer's disease. We then discuss the latest stem cell news, papers, and a conference recently held in Los Angeles. And of course, we kick off your holiday season with a signature rant. Enjoy!
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In this episode our science roundup includes new Alzheimer's targets, bitter tasting genes, polio, and bacteria-fighting zinc. We talk briefly about some cool papers involving stem cells from obese patients and modeling Parkinson's in yeast.
We then bring in Dr. Asif Maroof, a post-doctoral fellow in the lab of Dr. Kevin Eggan at the Harvard Stem Cell Institute to talk about his latest paper in Nature Neuroscience describing a gene implicated in ALS a.k.a Lou Gehrig's disease. We finish off with our signature ran, this time about co-workers using up precious supplies. Enjoy!
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Photo Reference: Courtesy of Dr. Asif Maroof
In this episode we do things a little different. Since we both work on Parkinson's disease we will not be featuring a guest. Instead, we will talk about the etiology of the disease and cover various forms of therapy - with an emphasis on stem cells. Our science roundup includes: CO2 levels, "Project Einstein", paper retraction rates, SARS, and plexins. Enjoy!
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In this episode our science round up includes: RNAi pesticides, atomic clocks, corked wine and TCA, and review of an open-access journal investigation.
Our guest is Dr. Carl P. Wonders, the scientific affairs manager for the International Society for Stem Cell Research (ISSCR). We discuss the annual meeting, science outreach, and long-term goals for the society. Finally, we rant about super-long "table of contents" emails.
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Photo Reference: Courtesy of Dr. Carl Wonders
In this episode we continue right along starting with our science round up, which includes the CTE issue in the NFL, Nobel laureates, and more gut bacteria.
Then we interview stem cell biologist Dr. Daylon James to discuss the field of blood stem cells; different strategies and clinical implications. Then all of us rant about the lack of diversity in stem cell science.
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Photo Reference: Courtesy of New York Social Diary
In this episode our science roundup includes novel poop pills, anti-acne bacteria, and Eric Kandel's RB-AB 48 Alzheimer's target.
We then get into some hot stem cell papers, including one by Dr. Jacob Hanna's group recently published in Nature describing a method for 100% reprogramming efficiency. And finally we end with our signature rant about our pathetic government and the shutdown. Enjoy!
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Photo Reference: Courtesy of Dr. Jacob Hanna
In this episode we start off with a quick general science news roundup before discussing two new papers in stem cell research. Both papers appeared in the journal Nature.
The first describes a novel method of reprogramming somatic cells into iPSCs in vivo, and other describes a method to make a mini cerebral cortex from human embryonic stem cells. The senior author on the latter study, Dr. Juergen Knoblich, joins us to discuss this paper and its implications. And finally, we end with a good old, Seinfeld style, stem cell rant. Enjoy!
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Photo Reference: Courtesy of Dr. Juergen Knoblich
Welcome to the stem cell podcast hosted by Dr.’s Christopher Fasano and Yosif Ganat. Here we will give a brief introduction to the biology of stem cells and the future direction of this podcast.
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