Journal Club series presented by CGA-IGC: Recent Episodes
CGA-IGC
The Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC) was established in 1995 to improve understanding of the basic science of inherited colorectal cancer and the clinical management of affected families, with an emphasis on the particular aspects of caring for families living in the Americas. The Expert Approach to Hereditary Gastrointestinal Cancers podcast series (seasons 1 and 2), and more recently, the Journal Club podcast series (season 3, 4, 5), are presented by the CGA-IGC Education Committee.
This episode is hosted by Josie Baker, MS, CGC, a genetic counselor at The Ohio State University, and features Rachael Lopez, MPH, RD, CSO, a clinical research dietitian at the National Institutes of Health.
Together they discuss the considerations for individuals with Hereditary Diffuse Gastric Cancer Syndrome when considering a prophylactic gastrectomy. This episode highlights the professional experience when working with these individuals before and after surgery, as well as the challenges individuals may face during this process.
This episode is hosted by Matt Yurgelun, M.D, a GI medical oncologist at the Dana-Farber Cancer Institute in Boston, MA, and features a discussion between Zsofia Stadler, M.D, a GI medical oncologist at the Memorial Sloan Kettering Cancer Center, New York, NY and Andrea Cercek, M.D, a GI medical oncologist also at the Memorial Sloan Kettering Cancer Center, New York, NY.
Together they discuss "PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer" which was published in the New England Journal of Medicine and found here https://pubmed.ncbi.nlm.nih.gov/35660797/
This study showed a remarkable response to immune checkpoint inhibitors in Lynch syndrome-associated rectal cancers. This exciting work is reviewed and includes insightful discussion of the design, outcomes, side effects, and future questions raised by researchers.
This episode was recorded on October 25th, 2022 and reflects expert opinion at the time of the recording.
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This episode is hosted by Pooja Dharwadkar, M.D, assistant professor at the University of California San Francisco, and features a discussion between Carol Burke, M.D, codirector of the Hereditary Cancer Clinic at the Cleveland Clinic; Robert Hüneburg, M.D, gastroenterologist at the National Center for Hereditary Tumor Syndromes at University Hospital Bonn in Bonn, Germany; and Bryson Katona, M.D, director of the GI Cancer Genetics and Cancer Risk Evaluation programs at the Hospital of the University of Pennsylvania in Philadelphia, PA. They discuss the benefits of upper GI cancer surveillance in Lynch syndrome – specifically as it applies to gastric cancer – and the studies that have contributed to recent updates in the National Comprehensive Cancer Network screening and surveillance guidelines for individuals with Lynch syndrome.
This episode references the following articles:
“Upper endoscopic surveillance in Lynch syndrome detects gastric and duodenal adenocarcinomas,” found here: https://pubmed.ncbi.nlm.nih.gov/32859614/
“Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome,” found here: https://pubmed.ncbi.nlm.nih.gov/32930401/
“Clinically actionable findings on surveillance EGD in asymptomatic patients with Lynch syndrome,” found here: https://pubmed.ncbi.nlm.nih.gov/34252420/
This episode was recorded on July 9th, 2022 and reflects expert opinion at the time of the recording.
On the occasion of the 2022 #PrevivorDay and #HereditaryCancerWeek, we're delighted to bring you a podcast debate as part of the CGA-IGC 2022 Podcast Series - Episode 6.
This episode is hosted by Michael J. Hall, MD, MS, Fox Chase Cancer Centre and features Heather Hampel, MS, CGC, City of Hope and Matthew B. Yurgelun, MD, Dana-Farber Cancer Institute.
The debate features Professor Heather Hampel and Dr Matthew Yurgelun going head to head over "Is it Time for Universal Germline Genetic Testing for All GI Cancers?", which was published in the Journal of Clinical Oncology can be found here https://pubmed.ncbi.nlm.nih.gov/35649230/
This episode was recorded on September 19th, 2022 and reflects expert opinion at the time of the recording.
This episode is hosted by Beth Dudley, MS, MPH, CGC, University of Pittsburgh Medical Center and features Michael G. Goggins, M.B.B.CH., M.D., The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions.
Together they discuss “The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival” which was published in the Journal of Clinical Oncology and found here: https://pubmed.ncbi.nlm.nih.gov/35704792/
This episode was recorded on June 21st, 2022 and reflects expert opinion at the time of the recording.
This episode is hosted by Joshua Sommovilla, M.D, The Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia at the Cleveland Clinic and features Matthew Kalady, M.D, The Ohio State University Wexner Medical Center and Mohammad Abbas, M.D., MPH, Northwestern University.
Together they discuss “Evaluation of Urinalysis-Based Screening for Urothelial Carcinoma in Patients With Lynch Syndrome” which was published in the Journal of Dis Colon Rectum. and found here: https://pubmed.ncbi.nlm.nih.gov/34882627/
This episode was recorded on April 25th, 2022 and reflects expert opinion at the time of the recording.
This episode is hosted by Thomas (T.J.) Slavin, M.D.,FACMGG, PhD and features Rachel Hodan, MS, CGC, Genetic Counselor & Clinical Assistant Professor at Stanford University, Cancer GeneticsClinic and Kimberly Perez, MD, Gastrointestinal Medical Oncologist & Assistant Professor of Medicine, Dana Farber Cancer Institute.
Together they discuss “Patterns of germline and somatic testing after universal tumor screening for Lynch syndrome: A clinical practice survey of active members of the CGA-IGC” which was published in the Journal of Genetic Counseling and found here: https://pubmed.ncbi.nlm.nih.gov/35218578/
The CGA Clinical Practice Survey 2022: Universal Germline Testing for Colorectal Cancer is currently open and CGA-IGC members are invited to participate. Check your inbox for the survey link.
This episode was recorded on June 1st, 2022 and reflects expert opinion at the time of the recording.
This episode is hosted by Thomas (T.J.) Slavin, M.D.,FACMGG, PhD and features Bryson Katona, M.D., PhD, Director, Gastrointestinal Cancer Genetics Program & Assistant Professor of Medicine at the Hospital of the University of Pennsylvania; and Jessica Long, MS, CGC, Division of Hematology–Oncology, Department of Medicine at the University of Pennsylvania. Together they discuss the article “EUS-based Pancreatic Cancer Surveillance in BRCA1/BRCA2/PALB2/ATM Carriers Without a Family History of Pancreatic Cancer” which was published in Cancer Prevention Research and found here: https://pubmed.ncbi.nlm.nih.gov/34341011/
Studies mentioned during the podcasthttps://clinicaltrials.gov/ct2/show/NCT02478892?term=NCT02478892&draw=2&rank=1
https://clinicaltrials.gov/ct2/show/NCT02000089?term=CAPS5&draw=2&rank=1
https://clinicaltrials.gov/ct2/show/NCT04970056?term=PRECEDE&draw=2&rank=4
This episode was recorded on April 25th, 2022 and reflects expert opinion at the time of the recording.
This episode is hosted by Maureen May, MS, CGC and features Bronwyn Bedrick, M.D., M.S.C.I., who is a Gynecology and Obstetrics Resident Physician at Johns Hopkins Hospital. Together they discuss the article “Creating Breast and Gynecologic Cancer Guidelines for Transgender Patients With BRCA Mutations,” which was published in Obstetrics & Gynecology and found here: https://pubmed.ncbi.nlm.nih.gov/34735408/
Resources mentioned during the podcast
- WPATH Standards of Care (free to download in many different languages): Standards of Care - WPATH World Professional Association for Transgender Health (https://wpath.org/publications/soc)
- WPATH Provider Directory: WPATH World Professional Association for Transgender Health (https://www.wpath.org/provider/search?)
- UCSF Guideline: Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People | Gender Affirming Health Program (ucsf.edu) (https://transcare.ucsf.edu/guidelines)
This episode was recorded on March 3, 2022 and reflects expert opinion at the time of the recording.
This episode is hosted by Dr. Thomas Slavin (T.J.) and features Amy K. Otto, PhD, who is a Research Assistant Professor in the Department of Public Health Sciences at the University of Miami Miller School of Medicine. Together they discuss the article “Impact of Patients' Companions on Clinical Encounters Between Black Patients and Their Non-Black Oncologists,” which was published in JCO Oncology Practice and found here: https://pubmed.ncbi.nlm.nih.gov/33411574/
This episode was recorded on August 26, 2021 and reflects expert opinion at the time of the recording.
This episode is hosted by Dr. Thomas Slavin (T.J.) and features Rachel Pearlman, MS, CGC, who is a Licensed, Certified Genetic Counselor and Assistant Professor in the Department of Internal Medicine at The Ohio State University Comprehensive Cancer Center. Together they discuss the article “Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative,” which was published in JCO Precision Oncology and found here: https://pubmed.ncbi.nlm.nih.gov/34250417/
This episode was recorded on August 10, 2021 and reflects expert opinion at the time of the recording.
This episode is hosted by Dr. Thomas Slavin (T.J.) and features Dr. Eduardo Vilar-Sanchez. Dr. Vilar-Sanchez is a medical oncologist at MD Anderson Cancer Center. Together they discuss “Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa,” which was published in Gut and found here: https://pubmed.ncbi.nlm.nih.gov/32641470/
This episode was recorded on March 26, 2021 and reflects expert opinion at the time of the recording.
This episode is hosted by Dr. Thomas Slavin (T.J.) and features Dr. Bryson Katona and Dr. Suzanne MacFarland. Dr. Katona is a gastroenterologist at Penn Medicine and Dr. MacFarland is an oncologist in the Children’s Hospital of Philadelphia. Together they discuss their recent publication, “Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant,” published in Cancer Prevention Research and found here: https://pubmed.ncbi.nlm.nih.gov/33097490/
This episode was recorded on January 25, 2021 and reflects expert opinion at the time of the recording.
This episode is hosted by Dr. Thomas Slavin (T.J.) and features Dr. Carol Burke, a gastroenterologist at the Cleveland Clinic. They discuss a study of combination therapy to delay disease progression in patients with familial adenomatous polyposis, recently published in The New England Journal of Medicine, found here: https://pubmed.ncbi.nlm.nih.gov/32905675/
This episode was recorded on January 12, 2021 and reflects expert opinion at the time of the recording.
The sixth episode, hosted by Dr. TJ Slavin, features Dr. Sonia Kupfer, a gastroenterologist at University of Chicago and former CGA-IGC president. They discuss the updated clinical practice guidelines for hereditary diffuse gastric cancer that were recently published online in Lancet Oncology, found here: https://pubmed.ncbi.nlm.nih.gov/32758476/ .
This episode was recorded on September 21, 2020, and reflects expert opinion at the time of the recording.
The fifth episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Sir John Burn, who is a professor of clinical genetics at Newcastle University, and Dr. Toni Seppälä, who is a GI surgeon from University of Helsinki currently conducting a research fellowship at Johns Hopkins University. They discuss recently updated data from the CAPP2 study of aspirin chemoprevention in individuals with Lynch syndrome that was published in Lancet this summer, found here: https://pubmed.ncbi.nlm.nih.gov/32534647/.
This episode was recorded on September 22, 2020, and reflects expert opinion at the time of the recording.
This episode is hosted by Dr. Leah Biller and features Dr. Zsofia Stadler, a medical oncologist at Memorial Sloan Kettering Cancer Center and CGA council member, and Dr. Michael Hall, a medical oncologist at Fox Chase Cancer Center and CGA past president. They discuss data from Abstract 1500 (https://meetinglibrary.asco.org/record/185963/abstract), which reports on targeted therapy based on germline analysis of tumor-normal sequencing in a pan-cancer population, as well as data from the plenary presentation about the clinical trial KEYNOTE-177 (https://meetinglibrary.asco.org/record/186928/abstract), a study of pembrolizumab versus standard therapy for treatment of MSI-H metastatic colorectal cancer.
This episode was recorded on August 28, 2020 and reflects expert opinion at the time of the recording.
The third episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Dr. Arne Bleijenberg, who is a research fellow at Amsterdam University Medical Center, and Dr. Evelien Dekker, who is a professor in the Department of Gastroenterology & Hepatology and Gastrointestinal Oncology and the head of the Hereditary Cancer Center at the Amsterdam University Medical Center. They discuss the recently updated World Health Organization Guidelines on diagnosis of Serrated Polyposis Syndrome (SPS) (summarized here https://pubmed.ncbi.nlm.nih.gov/31982410/). Dr. Bleijenberg and Dr. Dekker also discuss their recent publications that shed light on a personalized approach to surveillance in SPS (https://pubmed.ncbi.nlm.nih.gov/30981990/) and long-term outcomes and natural disease course in those with SPS undergoing colonoscopic surveillance (https://pubmed.ncbi.nlm.nih.gov/32360902/). This episode was recorded on July 9, 2020 and reflects expert opinion at the time of the recording.
The second episode features Dr. Leah Biller, CGA education committee member, who is interviewed by fellow CGA education committee member TJ Slavin. They discuss "A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors", recently published online in Cancer Prevention Research. You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32051178
This episode was recorded May 5, 2020 and reflects expert opinion at the time of the recording.
Each episode of the 2020 season of the CGA-IGC podcast series will be a short journal club featuring a recently published article of interest to our membership.
The first episode features Brandie Heald Leach, former CGA president, who is interviewed by CGA education committee member TJ Slavin. They discuss the CGA-IGC position statement on multi-gene panel testing for hereditary colorectal cancer and polyposis, published online in Familial Cancer on March 14, 2020.
You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32172433
This episode was recorded April 8, 2020 and reflects expert opinion at the time of the recording.
The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The sixth and final episode features Kristin Zajo, a genetic counselor at Nationwide Children’s Hospital in Columbus Ohio. In this episode, we focus on children and young adults with FAP and special considerations regarding management and transitioning from pediatric to adult care.
Note: This episode was recorded on April 23, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The fifth episode features Dr. Jennifer Sipos, an endocrinologist at the Ohio State University. In this episode, she reviews the epidemiology, surveillance, and management of thyroid disease in FAP.
Note: This episode was recorded on April 26, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Episodes to come in Season 2:
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC
The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The fourth episode features Dr. James Church, colorectal surgeon, and Dr. Dale Shepard, medical oncologist, both of the Cleveland Clinic. In this episode, they discuss the biology, medical and surgical management of desmoid disease in FAP.
Note: This episode was recorded on August 15, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Episodes to come in Season 2:
- "Thyroid Lesion Management" with Jennifer Sipos, MD
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC
The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The third episode features Dr. Jewel Samadder, gastroenterologist and advanced endoscopist at the Mayo Clinic in Phoenix, Arizona. Dr. Samadder has a specific focus on hereditary cancer conditions, with distinct expertise in familial adenomatous polyposis. In this episode, Dr. Samadder discusses the necessary screening, endoscopic and surgical approaches, and chemoprevention options for duodenal neoplasia in FAP.
Note: This episode was recorded on July 16th, 2019 and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Episodes to come in Season 2:
- "Desmoids" with Dr. James Church and Dr. Dale Shepard
- "Thyroid Lesion Management" with Dr. Jennifer Sipos
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC
The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of APC-Associated conditions.
In the second episode, Dr. Daniel Worthley, an expert in hereditary cancer syndromes from the South Australian Health and Medical Research Institute, tells the tale of how Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) was first recognized and characterized. GAPPS is caused by a mutation in the promotor region of the APC gene and is inherited in an autosomal dominant fashion. This condition is associated with a significantly increased risk of gastric cancer, but unlike FAP, GAPPS is not associated with tumors in the colon or small bowel. Dr. Worthley reviews the characteristics of this rare condition and current approach to management.
Note: This episode was recorded on April 23, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
In the first episode, Dr. Dennis Ahnen interviews Drs. Carol Burke and Gautam Mankaney, who are both gastroenterologists in the Cleveland Clinic Hereditary Cancer Clinic. They discuss the types of polyps that may develop in the stomach of individuals with FAP, as well as the risk for gastric cancer in FAP.
Note: This episode was recorded on April 4, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
How to counsel patients about the link between Breast Cancer and Lynch Syndrome featuring Dr. Nadine Tung
In this episode, Dr. Katherine A. Germansky interviews Dr. Nadine Tung, Director of Breast Medical Oncology and Director of Cancer Genetics and Prevention Program at Beth Israel Deaconess Medical Center. She will be discussing the link between Lynch Syndrome and Breast Cancer.
Hosted by:
Katharine A. Germansky, MD
Gastroenterologist at Beth Israel Deaconess Medical Center
Note: This episode was recorded on 7/10/2018. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The content reflects expert opinion at the time of recording.
How to counsel patients about urologic cancer risks featuring Dr. Jodi Maranchie.
In this episode, Beth Dudley interviews Dr. Jodi Maranchie, a Urologist at the University of Pittsburgh. She will be discussing how she talks to Lynch Syndrome patients about urologic cancer risks, screening options and special considerations in treatment.
Hosted by:
Beth Dudley, MS
Genetic Counselor at University of Pittsburgh Medical Center
Note: This episode was recorded on 8/24/2018. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The content reflects expert opinion at the time of recording.
How to counsel patients about gynecologic cancer risks and family planning option in Lynch Syndrome featuring Dr. Leslie Garrett.
In this episode, Dr. Katherine A. Germansky interviews Dr. Leslie Garrett, Director of the Division of Gynecologic Oncology at Beth Israel Deaconess Medical Center. She will be discussing how she talks to Lynch Syndrome patients about family planning, gynecologic cancer risks, screening options and prophylactic surgery.
Hosted by:
Katharine A. Germansky, MD
Gastroenterologist at Beth Israel Deaconess Medical Center
Note: This episode was recorded on 8/1/2018. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The content reflects expert opinion at the time of recording.
How to counsel patients about cancer risks in Lynch Syndrome featuring Dr. Sonia Kupfer: Part II
In this episode, Dr. Swati G. Patel continues the conversation with Dr. Sonia Kupfer, Director of the Gastrointestinal Cancer Risk and Prevention Center at the University of Chicago. She will be discussing extra-intestinal cancer risks in Lynch Syndrome and strategies to minimize risk including screening and chemoprevention.
Hosted by:
Swati G. Patel, MD, MS
Gastroenterologist at University of Colorado and Director of GI Cancer Risk and Prevention Center
Note: This episode was recorded on 3/14/2018. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The content reflects expert opinion at the time of recording.
How to counsel patients about cancer risks in Lynch Syndrome featuring Dr. Sonia Kupfer: Part I
In the first episode, Dr. Swati G. Patel interviews Dr. Sonia Kupfer, Director of the Gastrointestinal Cancer Risk and Prevention Center at the University of Chicago. She will be discussing how she explains cancer risks to her Lynch Syndrome Patients. She will review her general approach to the discussion and review recommendations for decreasing risk of digestive cancers.
Hosted by:
Swati G. Patel, MD, MS
Gastroenterologist at University of Colorado and Director of GI Cancer Risk and Prevention Center
Note: This episode was recorded on 3/14/2018. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The content reflects expert opinion at the time of recording.