Hereditary Diseases Pod: Recent Episodes

Sanofi Genzyme

Hear the stories behind challenging cases in Australian practice. Join clinical experts as they discuss hereditary and often rare diseases and provide practical insights from their experiences to facilitate timely diagnosis and effective management.

Sanofi‐aventis australia pty ltd trading as Sanofi. ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12‐24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2200562. Date of Preparation March 2022. POM2200299

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Inherited cardiac disorders often pose a considerable diagnostic challenge due to their broad clinical diversity and genetic heterogeneity. Join Professor Chris Semsarian AM, Genetic Cardiologist at the Royal Prince Alfred Hospital in Sydney, as he illustrates the merits of genetic testing in clinical cardiology practice.

For more information about Detect genetic testing panels, please visit

https://sanofigenzymeonline.com.au/detect

The views and opinions expressed in the presentation are solely those of Professor Semsarian AM and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme. Professor Semsarian did not receive honoraria from Sanofi Genzyme.

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The diagnostic challenge of muscular dystrophies and neuromuscular disorders in children often stems from the broad, nondescript nature of presenting symptoms. Join Associate Professor Andrew Kornberg, Senior Paediatric Neurologist at the Royal Children’s Hospital in Melbourne, as he explores the role of genetic testing in the diagnosis and management of hereditary muscular dystrophies and neuromuscular disorders in children, using real-world case studies.

For more information about Detect genetic testing panels, please visit

https://sanofigenzymeonline.com.au/detect

Abbreviations: CK, creatine kinase; NMD, neuromuscular disorder.

The views and opinions expressed in the presentation are solely those of Associate Professor Andrew Kornberg and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme. Associate Professor Kornberg received honoraria from Sanofi Genzyme.

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Pompe disease is a rare but treatable neuromuscular disease with a spectrum of symptoms and a challenging diagnosis. Join Professor Merrilee Needham (Neurologist, Fiona Stanley Hospital & Perron Institute, Perth), co-author of the publication “Is it Pompe Disease? Australian Diagnostic Considerations”, as she explores Pompe disease red flags and diagnostic challenges using Australian case studies. This episode follows the diagnostic path of a patient with respiratory involvement.

Please click on the pdf attachment or the episode website for full show notes, including references & legal information.

References:

  1. Tchan M et al. Is it Pompe Disease? Australian diagnostic considerations. Neuromuscular Disorders 2020; 30: 389–99.

  2. Schuller A et al. American Journal Medical Genetics Clinical Seminars Medical Genetics 2012;160C:80–8

  3. Ausems MG et al. A diagnostic protocol for adult-onset glycogen storage disease type II. Neurology. 1999;52:851–3

For more information about testing for Pompe disease, please visit sanofigenzymeonline.com.au/diagnostics.

Abbreviations: EMG, electromyography; CK, creatine kinase

The views and opinions expressed in the presentation are solely those of Professor Merrilee Needham and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme. Professor Needham received honoraria from Sanofi Genzyme.

sanofi-aventis australia pty ltd trading as Sanofi Genzyme ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12–24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2002398. Prepared November 2020.

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Pompe disease is a rare but treatable neuromuscular disease with a spectrum of symptoms and a challenging diagnosis. Join Professor Merrilee Needham (Neurologist, Fiona Stanley Hospital & Perron Institute, Perth), co-author of the publication “Is it Pompe Disease? Australian Diagnostic Considerations”, as she explores Pompe disease red flags and diagnostic challenges using Australian case studies. This episode follows the diagnostic work-up of a patient with chronic elevated creatine kinase (hyperCKaemia).

Please click on the pdf attachment or the episode website for full show notes, including references & legal information.

References:

  1. Tchan M et al. Neuromuscular Disorders 2020; 30: 389–99
  2. Lukacs Z et al. Neurology 2016; 87:295–8
  3. Ausems MG et al. A diagnostic protocol for adult-onset glycogen storage disease type II. Neurology. 1999;52:851–3

For more information about testing for Pompe disease, please visit sanofigenzymeonline.com.au/diagnostics.

Abbreviations: EMG, electromyography; CK, creatine kinase; MLPA, multiplex ligation dependent probe amplification

The views and opinions expressed in the presentation are solely those of Professor Merrilee Needham and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme. Professor Needham received honoraria from Sanofi Genzyme.

sanofi-aventis australia pty ltd trading as Sanofi Genzyme ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12–24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2002396. Prepared November 2020

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Pompe disease is a rare but treatable neuromuscular disease with a wide spectrum of symptoms and a challenging diagnosis. Join Professor Merrilee Needham (Neurologist, Fiona Stanley Hospital & Perron Institute, Perth), co-author of the publication “Is it Pompe Disease? Australian Diagnostic Considerations”, as she explores Pompe disease red flags and diagnostic challenges using Australian case studies. This episode illustrates the non-specific signs and symptoms that can delay diagnosis in a patient with limb-girdle weakness.

References:

  1. Tchan M et al. Is it Pompe Disease? Australian diagnostic considerations. Neuromuscular Disorders 2020; 30: 389–99

  2. Lin et al Lin CY, Hwang B, Hsiao KJ, Jin YR. Pompe's disease in Chinese and prenatal diagnosis by determination of alpha-glucosidase activity. J Inherit Metab Dis 1987;10:11–7

  3. Kishnani PS et al, on behalf of the Pompe Registry Boards of Advisors. 2013. Timing of diagnosis of patients with Pompe disease: Data from the Pompe Registry. Am J Med Genet Part A 161A:2431–2443

For more information about testing for Pompe disease, please visit sanofigenzymeonline.com.au/diagnostics.

Abbreviations: CK, creatine kinase

The views and opinions expressed in the presentation are solely those of Professor Merrilee Needham and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme. Professor Needham received honoraria from Sanofi Genzyme.

Sanofi-aventis australia pty ltd trading as Sanofi ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12–24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2200562. Date of Preparation March 2022. POM2200299

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Pompe disease is a rare neuromuscular disease with a spectrum of symptoms and a challenging diagnosis. Join co-authors of the publication “Is it Pompe Disease? Australian Diagnostic Considerations”, Associate Professor Robert Henderson (Neurologist, Royal Brisbane and Women’s Hospital, Brisbane) and Associate Professor Andrew Kornberg (Paediatric Neurologist, Royal Children’s Hospital, Melbourne) as they present two case studies from their practice and discuss the management of Pompe disease.

Reference:

  1. Tchan M et al. Is it Pompe Disease? Australian diagnostic considerations. Neuromuscul Disord 2020; 30: 389–99.

The views and opinions expressed in the presentation are solely those of Associate Professor Kornberg and Associate Professor Henderson and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme. Associate Professor Kornberg and Associate Professor Henderson received honoraria from Sanofi Genzyme.

Sanofi-aventis Australia Pty Ltd trading as Sanofi Genzyme ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12–24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2000610. POM0016. Prepared August 2020.

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Pompe disease is a rare neuromuscular disease with a spectrum of symptoms and a challenging diagnosis. Join co-authors of the publication “Is it Pompe Disease? Australian Diagnostic Considerations”, Associate Professor Robert Henderson (Neurologist, Royal Brisbane and Women’s Hospital, Brisbane) and Associate Professor Andrew Kornberg (Paediatric Neurologist, Royal Children’s Hospital, Melbourne) as they explore the practical aspects of diagnosing Pompe disease, including the clinical assessment, differential diagnosis and testing.

References:

  1. Tchan M et al. Is it Pompe Disease? Australian diagnostic considerations. Neuromuscul Disord 2020; 30: 389–99.

  2. O’Callaghan C et al. Adult-onset Pompe’s disease presenting with insidious hypercapnic respiratory failure Respirol Case Rep 2016; 4(5): e00178.

The views and opinions expressed in the presentation are solely those of Associate Professor Kornberg and Associate Professor Henderson and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Associate Professor Kornberg and Associate Professor Henderson received honoraria from Sanofi.

Sanofi-aventis australia pty ltd trading as Sanofi ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12–24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2200562. Date of Preparation March 2022. POM2200299

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Pompe disease is a rare neuromuscular disease with a spectrum of symptoms and a challenging diagnosis. Join co-authors of the publication “Is it Pompe Disease? Australian Diagnostic Considerations”, Associate Professor Robert Henderson (Neurologist, Royal Brisbane and Women’s Hospital, Brisbane) and Associate Professor Andrew Kornberg (Paediatric Neurologist, Royal Children’s Hospital, Melbourne) as they review the early signs and symptoms of Pompe disease and how they can be investigated.

References:

  1. Tchan M et al. Is it Pompe Disease? Australian diagnostic considerations. Neuromuscul Disord 2020; 30: 389–99.

  2. Kishnani PS et al. A retrospective, multinational, multicenter study on the natural history of infantile-onset Pompe disease. J Pediatr 2006; 148(5): 671–6.

  3. Hirschhorn R and Reuser AJ. Glycogen storage disease type II: acid alpha-glucosidase (acid maltase) deficiency. In: Scriver C, Beaudet A, Sly W, Valle D, eds. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill, 2001; 3389–420.

  4. Gutierrez-Rivas E et al. Targeted screening for the detection of Pompe disease in patients with unclassified limb-girdle muscular dystrophy or asymptomatic hyperCKemia using dried blood: a Spanish cohort. Neuromuscul Disord 2015; 25 (7): 548–5.

The views and opinions expressed in the presentation are solely those of Associate Professor Kornberg and Associate Professor Henderson and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi. Associate Professor Kornberg and Associate Professor Henderson received honoraria from Sanofi.

Sanofi-aventis australia pty ltd trading as Sanofi ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12–24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2200562. Date of Preparation March 2022. POM2200299

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In part two, Associate Professors Andrew Kornberg and Carolyn Ellaway review the considerations for managing Fabry disease in Australia and provide practical guidance on diagnosis and treatment, including the steps required for screening and referring to specialist centres. Intended for healthcare professional audiences.

For more information about diagnostic testing, please visit sanofigenzymeonline.com.au/diagnostics

The Fabry association mentioned in this podcast is Fabry Australia. More information about this not-for-profit can be found at fabry.com.au.

The list of Fabry disease clinics in Australia can be found on the Fabry Australia website at fabry.com.au/fabry-clinics and are listed below for convenience. Please note that patients from Tasmania are referred to Royal Melbourne Hospital, patients from Darwin are referred to Brisbane hospitals and patients from Alice Spring are referred to Royal Adelaide Hospital.

Royal Adelaide Hospital

Associate Professor Ian Chapman

Internal Medicine

Location: Royal Adelaide Hospital

Email: ian.chapman@adelaide.edu.au

Phone: +61 8 8222 4162

Royal Brisbane and Women's Hospital (QLD)

Dr Charles Denaro

Internal Medicine & Aged Care

Location: Royal Brisbane & Women's Hospital (QLD)

Email: c.denaro@uq.edu.au

Phone: +61 7 3646 7678

Royal Melbourne Hospital (Vic & Tas)

Dr Kathy Nicholls

Nephrologist

Location: Royal Melbourne Hospital

Address: Grattan St, Parkville, VIC, 3050

Phone: +61 3 9342 7143

Royal Perth Hospital (WA)

Dr Mark Thomas

Nephrologist

Location: Royal Perth Hospital

Address: 197 Wellington St, Perth WA 6000

Email: mark.thomas@health.wa.gov.au

Phone: +61 89224 2550

Westmead Hospital

Dr Michel Tchan

Metabolic Clinic

Location: Westmead Hospital (NSW & ACT)

Email: michel.tchan@health.nsw.gov.au

Phone: +61 2 9845 9780

Australian Paediatric Fabry Clinics

Royal Children's Hospital (Vic)

Dr Heidi Peters and Dr Joy Lee

Clinical Metabolic Services

Location: Royal Childrens Hospital (VIC)

Email: metabolic@rch.org.au

Phone: +61 3 9345 6251

Women's and Children's Hospital (SA)

Dr Drago Bratkovic

Metabolic Clinic

Location: Women's and Children's Hospital, SA

Email: drago.bratkovic@health.sa.gov.au

Phone: +61 8 8161 6726

Royal Children's Hospital (QLD)

Dr Jim McGill

Metabolic Medicine

Location: Royal Children's Hospital (QLD)

Email: jim_mcgill@health.qld.gov.au

Phone: +61 7 3646 8111

King Edward Memorial Hospital (WA)

Associate Professor Nicholas Pachter

Genetic Services of Western Australia

Location: King Edward Memorial Hospital (WA)

Email: Nicholas.Pachter@health.wa.gov.au

Phone: +61 6458 1525

The Children's Hospital at Westmead (NSW)

Dr Carolyn Ellaway

Genetic Metabolic Disorders Services

Lysosomal Disorders Multidisciplinary Management Clinic

Location: The Children's Hospital at Westmead (NSW)

Email: carolyn.ellaway@health.nsw.gov.au

Phone: +61 2 9845 3654

Reference:

  1. Ellaway C. Transl Pediatr 2016;5(1):37–42.

The views and opinions expressed in the presentation are solely those of Associate Professor Carolyn Ellaway and Associate Professor Andrew Kornberg and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme.

sanofi‐aventis australia pty ltd trading as Sanofi Genzyme. ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12‐24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2102516. Date of preparation December 2021. 2200137.

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In the concluding episode, Associate Professor Carolyn Ellaway evaluates the management of Fabry disease in Australia from her patient’s perspective, reviewing their journey from mystery illness to treatable disease. Intended for healthcare professional audiences.

For more information about diagnostic testing, please visit sanofigenzymeonline.com.au/diagnostics

See episode website for full notes, including references & legal information.

The views and opinions expressed in the presentation are solely those of Associate Professor Carolyn Ellaway and Associate Professor Andrew Kornberg and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme.

sanofi‐aventis australia pty ltd trading as Sanofi Genzyme. ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12‐24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2102516. Date of preparation December 2021. 2200137.

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Fabry disease is a rare genetic metabolic disease with a challenging clinical presentation. Associate Professors Andrew Kornberg (Paediatric Neurologist, Royal Children’s Hospital Melbourne) and Carolyn Ellaway (Paediatrician, Clinical Geneticist and Metabolic Physician, Sydney Children’s Hospital Network) discuss the signs of Fabry disease, the importance of early diagnosis and how it can be treated. Intended for healthcare professionals.

For more information about diagnostic testing, please visit sanofigenzymeonline.com.au/diagnostics

References:

  1. Schiffmann R. Pharmacol Ther 2009;122:65–77.
  2. Schiffmann R and Ries M. Pediatr Neurol 2016;64:10e20.
  3. Laney DA et al. Genet Med 2015;17(5):323–30.
  4. Sims K et al. Stroke 2009;40:788–94.
  5. Hopkin RJ et al. Mol Genet Metab 2016;117(2):104–13.
  6. Tøndel C et al. J Am Soc Nephrol 2013;24(1):137–48.
  7. Skrunes R et al. Clin J Am Soc Nephrol 2017;12(9):1470–9.

The views and opinions expressed in the presentation are solely those of Associate Professor Carolyn Ellaway and Associate Professor Andrew Kornberg and should not be attributed to any organisation with which the presenter is employed or affiliated and are not necessarily the views of Sanofi Genzyme.

sanofi‐aventis australia pty ltd trading as Sanofi Genzyme. ABN 31 008 558 807. Talavera Corporate Centre, Building D, 12‐24 Talavera Road, Macquarie Park, NSW 2113. MAT-AU-2102516. Date of preparation December 2021. 2200137