POEM of the Week Podcast: Recent Episodes
Mark Ebell and Michael Wilkes
Each week, Dr. Mark Ebell, POEMs Editor, joins Dr. Michael Wilkes, NPR correspondent and Vice-Dean of the UC-Davis Medical School, for a five minute discussion about an important recent medical study reviewed by the POEMs editors. POEMs provide synopsised reviews of studies that could affect a clinician's practice, and the discussion in this podcast provides additional depth and insight into the issue covered by the POEMs synopsis. More about POEMs and it's companion point-of-care search tool, Essential Evidence Plus, at www.essentialevidenceplus.com.
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Monoclonal antibodies for Alzheimer disease: A lack of clinically meaningful benefits, plus significant harms '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Patient reminders combined with clinician audit and feedback increases human papillomavirus vaccine uptake '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Canadian Thoracic Society guidelines for pharmacotherapy of stable chronic obstructive pulmonary disease '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Scottish screening: 0 cases of invasive cervical cancer in women who received at least 1 dose of bivalent HPV vaccine at 12 or 13 years of age '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' High-dose recombinant flu vaccine: NNT = 3000 to prevent one more infection, no impact on hospitalization '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Delivery of bad news via phone = in-person delivery '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' PCI is better than placebo for stable angina in patients who do not take anti-anginal medications (ORBITA-2) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Wait-and-watch is an option for patients with symptomatic but uncomplicated gallstones '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brexpiprazole improves agitation scores in adults with Alzheimer disease who have agitated behaviors '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' ACC/AHA guideline for the management of patients with chronic coronary disease '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Positive, rather than negative, messaging of weight loss might motivate patients to try to lose weight '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brief behavioral therapy diminishes insomnia in the elderly '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Chlorthalidone no better than hydrochlorothiazide for hypertension '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tell patients their new knee won't wear out sooner with hard use '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Majority of CIN2 regress in women aged 25 to 30 years '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tocilizumab beneficial for adults with persistent polymyalgia rheumatica symptoms who receive steroid therapy '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Improved decongestion with the addition of acetazolamide to intravenous loop diuretics for acute heart failure '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Rebound symptoms common with COVID-19 even after placebo treatment '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Limited evidence for meds, music, and massage to treat anxiety in residents of long-term care facilities '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35% '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nonpharmacologic approaches can improve fibromyalgia symptoms '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amitriptyline, duloxetine, and pregabalin each effective in decreasing pain from diabetic peripheral neuropathy; combinations even better '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Polypill better for secondary cardiovascular prevention than physician-directed care '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nirmatrelvir/ritonavir (Paxlovid) reduces hospitalization, mortality in patients 65+ with COVID-19; effect on younger patients unclear '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Likelihood of long COVID varies by variant, sex, and vaccination status '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Overuse alert: Pharmacogenomic testing for selection of antidepressant provides minimal, if any, benefit (PRIME) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Greater social determinants of health burden associated with an increased risk of hospitalization '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tirzepatide helps obese adults without diabetes lose 15% to 21% of their body weight over 72 weeks '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Supplemental vitamin D does not reduce the risk of fracture in older adults (VITAL) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Screening for atrial fibrillation in primary care is not effective (VITAL-AF) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Fewer than 4% of children with newly diagnosed hypertension in primary care or school settings have secondary causes '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Minimal difference, if any, in the efficacy of intramuscular vs intra-articular steroid injection for knee osteoarthritis '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Long-term risks are similar for CT and invasive coronary angiography as initial diagnostic strategy for stable chest pain '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Medication abortion for pregnancy of unknown location a reasonable option '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' USPSTF 2022 recommends against initiating aspirin for primary prevention of cardiovascular disease in adults 60+ years (D recommendation) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Aducanumab is not effective for mild cognitive impairment or mild Alzheimer's dementia and has major safety issues '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Surgery is no better than nonoperative treatment for Achilles tendon rupture in adults '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ketamine reduces suicidal ideation quickly, but may not reduce the short-term likelihood of suicide attempts '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Combination antidepressant therapy is more effective than monotherapy for acute severe depression and nonresponding depression '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Closed-loop system improves glycemic control but not hypoglycemia for young children with type 1 diabetes mellitus '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Selective serotonin reuptake inhibitors are probably the best first option for patients with panic disorder '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' All-cause mortality is comparable in patients with left main coronary artery disease treated with PCI or CABG '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' MA: Several drugs are effective for weight loss in obese or overweight adults; it's unclear whether they improve health outcomes '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Large increases in the risk of cardiovascular events following COVID-19 infection that required hospitalization '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Thromboprophylaxis after discharge improves clinical outcomes for certain high-risk patients hospitalized with COVID-19 (MICHELLE) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Proton pump inhibitor use associated with an increased risk of gastric cancer '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' British Society of Gastroenterology guidelines for the management of irritable bowel syndrome '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nirmatrelvir/ritonavir (Paxlovid) reduces risk of hospitalization in at-risk outpatients (EPIC-HR) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No improved patient-oriented outcomes with sacubitril/valsartan in adults with heart failure and preserved EF (PARALLAX) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amoxicillin for children with CAP: low-dose for 3 days is noninferior to high-dose for 7 days (CAP-IT) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lowering blood pressure does not decrease the risk of T2DM in persons with hypertension; ACEIs/ARBs do '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' DAPT with aspirin plus clopidogrel for 30 days is the best option after minor stroke or TIA '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' For mild/moderate acne, adapalene + BPO, clindamycin + BPO, and adapalene alone are most effective, in that order '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Platelet-rich plasma injections are not superior to placebo injections for ankle osteoarthritis '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Midodrine is worth a trial in people with frequent episodes of vasovagal syncope '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' In-office procalcitonin testing can lead to less antibiotic prescribing '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Empagliflozin reduces hospitalization for heart failure with preserved ejection fraction (NNT = 59 per year), but not mortality outcomes (EMPEROR-Preserved) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Relapse of depression more likely after discontinuation of medication (number needed to treat to harm = 6). '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amoxicillin does not improve outcomes for nonpneumonia lower respiratory tract infection in children (ARTIC PC) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Predictive values for 6 common abdominal symptoms '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Some patients are willing to consider delayed antibiotic treatment of respiratory tract infection '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Only one cerumenolytic assists with in-office manual disimpaction of ear wax '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Salt substitute reduces mortality and stroke in elderly patients who have a history of, or are at risk of, stroke '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Universal depression screening in primary care: 77% false positives '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Iron supplementation in infants living in countries with a high prevalence of anemia does not improve cognition or development '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Evidence of benefit is lacking for low back pain relief with muscle relaxants '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Every-other-year FIT is at least as effective as a single sigmoidoscopy to detect colorectal cancer '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Third Pfizer vaccine dose significantly increases protection against both mild and severe COVID-19 in patients 60 years+ '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Guidelines for when to consider mortality-reducing treatments for patients with type 2 diabetes '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Telephone-based cognitive behavioral therapy for insomnia is effective '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' High-frequency spinal cord stimulation improves pain in patients with refractory painful diabetic neuropathy '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' AHA guideline for secondary stroke prevention '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Left atrial appendage occlusion during cardiac surgery for another reason reduces the risk of stroke (NNT = 43 over 4 years) '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Some nonpharmacological treatments may decrease migraine frequency in children and adolescents '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ultrasound is accurate for diagnosing upper extremity fractures in children '
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Routine MRI reports for low back pain may decrease function and worsen pain because of Catastrophizing language '