This Week in Virology: Recent Episodes
Vincent Racaniello
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
TWiV explains research showing that Long COVID is associated with reactivation of numerous chronic viruses, including herpesviruses and anelloviruses, and with the production of autoantibodies that target neurological tissues.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Virus reactivation in acute and long COVID-19 (Cell) * Association between autoantibodies and neurological symptoms in long COVID (Cell) * Letters read on TWiV 1347 * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Brianne – Merriam-Webster Time Traveler Feature Alan – The Incandescent, by Emily Tesh Vincent – How mosquitoes are conquering the world — in four charts
Listener Picks Vici – PBS Eons Charles – Entomologist Stephen Dobson on releasing modified mosquitoes to fight disease
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are distressed by Erica Schwartz’ confirmation as CDC director, the GAO proposed pandemic preparedness plans, the national cyclospora outbreak and resulting two deaths, new screwworm and the scale of the Ebola outbreak in the Congo, and clear results from some of President Trump’s policies dismantling public health activites including water safety, before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, FDA approval of Moderna’s mRNA vaccine for seasonal flu, how to access and pay for Paxlovid, where to go for answers about long COVID-19, how SARS-CoV-2 infections may reactivate latent viral infections, particularly Aniello virus, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Senate confirms Erica Schwartz as CDC director (CIDRAP) * PUBLIC HEALTH PREPAREDNESS: Experts Identified Actions to Improve Surveillance for Emerging Disease Threats (Government Accountability Office) * Association Between First MMR Vaccination Before Age 2 Years and Childhood Autism in a U.S. EHR Cohort of 2.5 Million Children (The Pediatric Infectious Disease Journal) * F.D.A. Approves Moderna’s mRNA Flu Vaccine(NY Times) * Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults (NEJM) * Two Deaths Linked to Cyclosporiasis in Michigan (NY Times) * CDC expands largest known cyclosporiasis outbreak to 15 states (Washington Post) * Surveillance of Cyclosporiasis (CDC: Cyclosporiasis) * Infectious DiseaseOutbreaks (Michigan: Health & Human Services) * Cyclosporiasis Cases in North Carolina (North Carolina: Division of Public Health) * Cyclospora Infection (Cyclosporiasis) (NYC Health) * Missouri Communicable Disease Report (2026) (Missouri Health) * Irrigation & Water Use (USDA: Economic Research Service) * A Guide to OSHA’s Field Sanitation Standard (OSHA) * Turm purge at FDA and USDA triggers food safety ‘brain drain’ (FOODNavigator) * Foodborne Illness Surveillance Systems (CDC) * About Campylobacter infection (CDC: Campylobacter infection (Campylobacteriosis)) * About Cyclosporiasis (CDC: Cyclosporiasis) * About ListeriaInfection (CDC: Listeria Infection (Listeriosis)) * About SalmonellaInfection (CDC: Salmonella Infection (Salmonellosis)) * About Escherichia coli Infection (CDC: E.Coli Infection (Escherichia coli)) * About Shigella Infection (CDC: Shigella-Shigellosis) * About VibrioInfection (CDC: Vibrio Infection (Vibriosis)) * About YersiniaInfection (CDC: Yersinia Infection (Yersiniosis)) * CDC Reveals Cause of Malaria’s Return to US After 20 Years(Newsweek) * Trump Dismantles USAID: Experts Say Move Will Help America’s Rivals and Harm Millions (Newsweek) * What we truly know about the huge US Cyclospora outbreak—and what we don’t (CIDRAP) * It’s The Water, Not Produce, Likely Driving Cyclospora Outbreaks (Forbes) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Ebola dashboard (ebola.fyi) * EBOLA: The Democratic Republic of the Congo, 2026(WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * EXCLUSIVE: Congo’s Ebola epidemic started at least 4 months before it was detected (Science) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * HAP’s Latest News Pa. Launches New Measles Dashboard (Hospital + HealthSystem Association of Pennsylvania) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Moderna’s mRNA flu shot mFlusiva snags FDA nod after refusal-to-file imbroglio (Fierece Pharma) * Weekly surveillance report: clift notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Household Transmission of SARS-CoV-2 in Washington and Oregon, United States, 2022-2024 (Journal of the Pediatric Infectious Diseases Society) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Virus reactivation in acute and long COVID-19 (Nature) * Reaching out to US house representative * Letters read on TWiV 1346 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV travels to Colorado State University in Ft. Collins, where he speaks with Angela Bosco-Lauth, Rebekah Kading, and Mark Stenglein about their careers and their virology research.
Host: Vincent Racaniello Guests: Angela Bosco-Lauth, Rebekah Kading, and Mark Stenglein
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Susceptibility of wild and domestic songbirds to Usutu virus (PLoS NTD) * Rabbit Hemorrhagic Disease Virus 2 Infection in Snowshoe Hares (J Wildl Dis) * SARS-CoV-2 Delta variant transmission among red fox and striped skunk (Virology) * Susceptibilities and viral shedding of peridomestic wildlife infected with clade 2.3.4.4b H5N1 (Virology) * Socioeconomic benefits associated with bats (J Ethnobiol Ethnomed) * Intrinsic factors driving mosquito vector competence (Front Cell Inf Micro) * Modernizing the Toolkit for Arthropod Bloodmeal Identification (Insects) * Can Bats Serve as Reservoirs for Arboviruses? (Viruses) * The Case for Studying New Viruses of New Hosts (Ann Rev Virol) * Rapid evolution of SARS-CoV-2 in domestic cats (Virus Evol) * Safety study of Rift Valley Fever human vaccine candidate in mosquitoes (Transbound Emerg Dis) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the numerous attempts by states to roll back vaccine laws, the recent surge of Dengue virus cases in Sri Lanka, the national cyclospora outbreak, new screwworm and Legionnaires cases, launching of the CHaT-Ox Ebola vaccine trail, scale of the Ebola outbreak in the Congo and if cross-reactive Ebola antibodies are effective, before Dr. Griffin deep dives into the measles outbreak including the new Pennsylvania dashboard, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how to access and pay for Paxlovid, where to go for answers about long COVID-19, how long COVID and ME/CFS differ and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Dozens of States Tried to Roll Back Vaccine Laws. Here’s How They Fared. (NY Times) * Dengue cases in Sri Lanka surge past 80,000 (Newswire) * After withdrawing false-positive test, FDA says Taylor Farms lettuce still a focus of Cyclospora investigation (CIDRAP) * A difficult-to-trace parasite, messaging missteps contribute to summer of overwhelming Cyclospora outbreaks (CIDRAP) * Surveillanceof Cyclosporiasis (CDC: Cyclosporiasis) * Infectious DiseaseOutbreaks (Michigan: Health & Human Services) * Cyclosporiasis Cases in North Carolina (North Carolina: Division of Public Health) * Cyclospora Infection (Cyclosporiasis) (NYC Health) * Legionnaires’ Disease (NYC Health) * MAP UPDATE: 50 buildings in Manhattan outbreak zone test positive for live bacteria (NBC: News) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * First volunteer vaccinated in the world’s first Bundibugyo ebolavirus vaccine trial (University of Oxford) * Cross-Reactive Bundibugyo Antibody Responses after Receipt of Licensed Ebola Vaccines (NEJM) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * HAP’s Latest News Pa. Launches New Measles Dashboard (Hospital + HealthSystem Association of Pennsylvania) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Impact of Nirsevimab in Its Second Season on Respiratory Syncytial Virus and Non-RSV Admissions in Children Under 5 (Pediatric Infectious Disease Journal) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Remdesivir and All-Cause Graft Loss Among Kidney Transplant Recipients With Symptomatic COVID-19 (JAMA: Network Open) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest (Nature Communications) * Loss of vesicular monoamine transporter 2 in striatum of long COVID and relationship to neuropsychiatric symptoms (eBioMedicine) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1344 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research which shows that Per os infectivity factors are essential for bracovirus infection and wasp parasitism, and that periodic shifts in viral load increase risk of Hendra virus spillover from Pteropus bats.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Susumu Tonegawa Dies (Wikipedia) * Measles Cases Hit New Record in U.S., as Vaccination Rates Wane (NYTimes) * Polydnaviruses on on TWiVs 372 and 443 * Per os infectivity factors essential for bracovirus infection and wasp parasitism (PNAS) * Periodic shifts in viral load increase risk of Hendra virus spillover from Pteropus bats (Sci Adv) * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Kathy – A) Sign up for ScienceAdviser daily newsletter, free B) Goats DO get brain damage from head butting (Original bioRxiv preprint) Rich – This Star Just Ate a Planet, and It’s Not Done Yet Alan – Schisto and Ladders educational board game story, and the original publication on it. Vincent – How female dolphins know which males to avoid (Original article)
Listener Pick David – What’s Under Your Feet in New York City? Ken – The usefulness of useless knowledge
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello explore the source/not source of the national cyclospora outbreak, trust in the FDA to correctly identify the source, new screwworm, Legionnaires and cyclosporasis cases, the Ebola outbreak in the Congo and development of a novel vaccine and antiviral before Dr. Griffin deep dives into the measles outbreak including the new Pennsylvania dashboard, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, difference between high and standard dose influenza vaccines, how to access and pay for Paxlovid, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * How helpful is not up to date? CDC: cyclosporiasis * Taylor Farms pulls Mexican Lettuce on Cyclospora Cases (Bloomberg) * FDA retracts positive cyclospora test on Taylor Farms lettuce (NPR: WHYY) * False-positive lab sample DOES NOT change the basis for FDA’s ongoing outbreak investigation (X) * FDA retracts test result but still links Taylor Farms lettuce to cyclosporiasis (Washington Post) * Infectious Disease Outbreaks (Michigan: Health & Human Services) * Cyclospora Infection (Cyclosporiasis) (NYC Health) * Legionnaires’ Disease (NYC Health) * Chapter 8: Cooling Towers (NYC Health) * You can verify ifa person is licensed on the New York State Office of the Professions website: (NSPE-NY) * Board for global EHS Credentialing (American Board of Industrial Hygiene) * Water treatment vendor (Association of Water Technologies) * Cooling Towers: Information for Owners and Operators (NYC Health) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026(WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo(WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * HAP’s Latest News Pa. Launches New Measles Dashboard (Hospital + HealthSystem Association of Pennsylvania) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles(CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Influenza vaccine effectiveness against outpatient acute respiratory illness withlaboratory-confirmed influenza, United States, 2024–25 season (CID) * Effect of high-dose versus standard-dose influenza vaccines on hospitalisation outcomes and mortality in older adults: a systematic review and meta-analysis (LANCET: Healthy Longevity) * Weekly surveillance report: clift notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Randomized, Double-Blind, Placebo-Controlled First-in-Human Trial of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix (JID) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1342 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research that reveals dual activity of a phage-encoded lysin that modulates infection dynamics in a mycobacteriophage, and refutes a proposed link between the SARS-CoV-2 furin cleavage site and mouse-adapted MERS-coronavirus MA30.
Hosts: Vincent Racaniello, Kathy Spindler, Angela Mingarelli, and Jolene Ramsey
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Dual activity of phage-encoded lysin (mBio) * Furin cleavage site and SARS-CoV-2 origins (PNAS) * Theories on SARS-CoV-2 origins (CR Biol) * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Angela – Pigeons. An underappreciated animal. Superparamagnetic macrophages, cancer detectors, mirror mark test Kathy – Wednesday’s APOD and Graphene Jolene – Microbial Puppet Masters science exhibit, 3D-models linked in their paper Vincent – Beyond Inheritance by Roxanne Khamsi (TWiEVO 126)
Listener Pick Lana – The Episodic Table of Elements
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello debate if Senator Mitch McConnell’s recent hospitalization is due to post-polio syndrome or just old age, how air quality from Maine to Chicago has been affected by the Ontario wild fires, new screwworm, Legionnaires and cyclosporasis cases, the Ebola outbreak in the Congo and development of a novel vaccine and antiviral, before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how to access and pay for Paxlovid, where to go for answers about long COVID-19, long term effects of COVID-19 immune dysfunction including ocular and gut and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Statement From Senator Mitch McConnell (Mitch McConnell US Senator for Kentucky) * Polio(NY Department of Health: Polio) * Global polio vaccination (CDC) * For Some Survivors, Polio Casts a Long Shadow (GAVI) * Former Republican Senate Majority Leader Mitch McConnell hospitalized (NPR) * Hundreds of thousands of Americans live with the long-term effects of polio (CIDRAP) * Child Care, Schools, Camps: Outdoor Air Quality Health Recommendations Based on Air Quality Index (NY City of Health: air quality) * Current Air Quality (AirNow) * Domestically Acquired Cyclosporiasis Cases in Multiple U.S. States, 2026 (CDC: Health Alert Network) * How helpful is not up to date? CDC: cyclosporiasis * Top 10 Cyclospora questions (Katelyn Jetelina: your local epidemiologist) * Cyclospora, wildfire smoke, and another Legionella outbreak (Marisa Donnelly: your local epidemiologist in New York) * Cyclospora keeps climbing, a bad West Nile season, truck spraying, and good news (Katelyn Jetelina and Marisa Donnelly: your local epidemiologists) * Infectious Disease Outbreaks (Michigan: Health & Human Services) * Cyclospora cases up dramatically in New York (Outbreak News Today) * Cyclospora Infection (Cyclosporiasis) (NYC Health) * Legionnaires’ Disease (NYC Health) * New York officials find Legionella in 76 cooling towers as cases hit 63 (CIDRAP) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * Why the fastest-growing Ebola outbreak in history is becoming more challenging (AP News) * Oxford begins first human trial of Bundibugyo Ebola vaccine (Reuters) * Gilead launches Ebola antiviral trial in DR Congo as cases near 2,000 (CIDRAP) * Information for Travelers Returning from Ebola-Affected Areas (CDC: Ebola) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long-term ocular symptoms following COVID-19 linked to immune dysregulation, dysautonomia and peripheral neuropathy (Nature Communications) * Vagal cholinergic denervationof the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction (International Journal of Infectious Diseases) * Reaching out to US house representative * Letters read on TWiV 1340 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Tom Ksiazek, a world-renowned virus expert with 40 years of experience on the front lines of some of the worst outbreaks the world has ever seen, joins TWiV to discuss his career, ebolaviruses in general, and the current outbreak of Bundibugyo ebolavirus in Africa.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Tom Ksiazek
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Fred Murphy passes (pdf) * CJ Peters passes (pdf) * Tom Ksiazek on TWiV 583 * Letters read on TWiV 1339 * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Brianne – APoD July 7: Dragons of Ara Rich – The Iconic Bass Riff That NOBODY Can Play; Riff (Wiki) see “Riff-Driven” Vincent – The song that made Carlos Santana a rock legend
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello are dismayed over the military deaths due to the voluntary influenza vaccination policy, FDA’s first vaccine recommendations since 2023, the efficacy of influenza vaccines, new screwworm, Legionnaires and cyclosporiasis cases, the Ebola outbreak in the DRC and Uganda and before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, use of antivirals in children with COVID-19, severe West Nile disease and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * A1C Keon Talik McDaniel (Bexar Memorial) * Hegseth: Flu Vaccine Optional (US Department of War) * Air Force trainee in San Antonio, Texas, died from flu(CIDRAP) * Key FDA committee unanimously recommends its first vaccine since 2023(NPR) * Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults (NEJM) * Influenza Vaccine Effectiveness Against Pediatric Death in the United States: 2016–2025 (Pediatrics) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Upper East Side Legionnaires’ Outbreak Source Remains Unknown (Bloomberg) * Outbreak of diarrhea-causing parasite grows to more than 1,000 cases (AP) * Cyclosporiasis outbreak in Michigan exceeds 1,000 cases (WOODTV+) * Ebola deaths top 500 as DR Congo health workers threaten to strike (CIDRAP) * Ebola deaths in Congo top 500 as health workers threaten to strike (AP) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots(CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Nirmatrelvir/Ritonavir for the Treatment of COVID-19 in Children Aged 6 Years and Older (Pediatrics) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Efficacy and safety of rivaroxaban, colchicine, and famotidine–loratadine with specialist supportive clinical care for fatigue in patients with post-COVID-19 condition in the UK: a multisite, open-label, randomised controlled trial (LANCET: Infectious Diseases) * Long-term Sequelae Associated With Severe West Nile Virus Disease in Maricopa County, Arizona, 2021 (OFID) * Reaching out to US house representative * Letters read on TWiV 1338 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research that reveals an an alternative evolutionary path of antiviral signalling in a sea anemone, and how a bacterial symbiont and a plant virus enhance insect fitness by inducing physical defenses against fungal parasites.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Springer-Nature retracted two papers by Max Planck, probably with a bot (Science) * Alternative evolutionary path of antiviral signalling in sea anemone (Nat Ecol Evol) * Bacterial symbiont and plant virus protect whitefly against fungal parasites (PNAS) * Letters read on TWiV 1337 * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Rich – The Mercy of Gods by James S. A. Corey; Livesuit by James S. A. Corey Alan – Climate.us, run by former NOAA scientists after Trump gutted their agency’s climate site Vincent – A Chemically Defined Synthetic Cell Capable of Growth and Replication
Listener Pick Lana – The Episodic Table of Elements
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello lament about the new ACIP charter, how administration of the HPV vaccine has eliminated cervical cancer deaths in young women, the global economic burden of infectious disease, restoring trust in vaccinology, new screwworm cases, the Ebola outbreak in the Congo and Uganda and need for preparedness, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * New ACIP charter broadens criteria for members, calls for review of alternatives to vaccines (STAT News) * ACIP Charter (CDC: Advisory Committee on Immunization Practices) * HPV vaccination eliminated cervical cancer deaths in young UK women in recent years, study suggests (CIDRAP) * Cervical cancer mortality trends following HPV vaccination in England, 2001–24: an analysis of population-based mortality data (LANCET) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * Size of the 2026 Ebola outbreak and risk of cross-border spillover from Bundibugyo virus in Ituri Province, DR Congo, and its implications for preparedness: a recalibrated stochastic modelling study (LANCET Infectious Diseases) * US CDC raises Ebola outbreak response to highest level (Reuters) * Construction of US-backed Ebola quarantine unit in Kenya is stopped (CIDRAP) * ASPR Supports Global Ebola Response While Strengthening U.S. Preparedness (Administration for Strategic Preparedness & Response) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * US military requires flu vaccine for some after outbreak in Texas training center (Reuters) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID Reaching out to US house representative * Letters read on TWiV 1336 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent speaks with Karen Torghele about her recently published biography of polio vaccine pioneer Albert Sabin, the first ever written.
Host: Vincent Racaniello Guest: Karen Torghele
Subscribe (free): Apple Podcasts, RSS, email
Links for this episode * Karen Torghele’s website * Purchase Albert Sabin by Karen Torghele (Bookshop or Amazon) * My letters from Albert Sabin (virology blog)
Become a patron of TWiV!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research showing how temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling, and that IgA antibody is necessary and sufficient to prevent norovirus infection in mice.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Fred Murphy passes away (X) * US has lost its hold on measles elimination (CIDRAP) * What’s in the genetic code of America’s measles outbreaks (ProPublica) * Did Pete Hegseth single-handedly raise the R₀ of flu? (Inside Medicine) * Fred Murphy’s Virus Images and Foundations of Virology (UTMB) * Temperate phages and RNA-guided flagellar remodelling (Nat Micro) * Eukaryotic RNA guided system (Nature) * IgA prevents norovirus infection in mice (Sci Transl Med) * Craig Wilen’s letter to TWiV (TWiV 492) * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Brianne – APod June 26: Milky Way Urban Style Rich – Your birth order affects your future, but not for the reason you think; Dr. McCoy Jolene – Bakteriopolis paper and site Vincent – The Claude Shutdown Is a Total Sh*tshow
Listener Pick Martin – Ancient text charred by Vesuvius read for first time in 2,000 years
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end of the hantavirus outbreak before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, outbreak of measles in Cook County Illionis in 2025, loss of measles elimination in the US, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Health and economic burdens of emerging infectious diseases in the USA, US territories and globally (BMJ Journal of Global Health) * Meeting People Where They Are: Scientist-Creators Delivering Trusted Health Information on Social Media and Beyond (The Evidence Collective) * Vaccine Integrity Project, The Evidence Collective announce projects to improve vaccine policy, restore trust (CIDRAP) * Outbreak of Legionnaires’ Disease Associated with Cooling Tower Systems in Central Harlem (NEJM Evidence) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * France confirms first Ebola case (BBC) * Hantavirusdashboard (Hantavirus.up) * Hantavirus on board with Prof. VincentRacaniello (microbeTV) * Health agencies signal end of quarantine period for cruise-linked Andes virus outbreak (DG:Alerts) * HHS Successfully Concludes Hantavirus Response Effort; Monitoring Ends with No Positive U.S. Case (US: HHS) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * US measles cases continue to climb, especially in Virginia (CIDRAP) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Measles Outbreak in Cook County, Illinois, September–October 2025 (NEJM Evidence) * CDC ‘transitioning away’ from diagnostic testing for measles, mumps (POLITICO PRO) * CIDRAP Op-Ed: Call it what it is—the US has lost its hold on measles elimination (CIDRAP) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * US military requires flu vaccine for some after outbreak in Texas training center (Reuters) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * CDC’s chief blocked a covid vaccine study. Now it’s in a top medical journal. (Washington Post) * Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design (JAMA Network: OPEN) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1334 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end of the hantavirus outbreak before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, outbreak of measles in Cook County Illionis in 2025, loss of measles elimination in the US, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Health and economic burdens of emerging infectious diseases in the USA, US territories and globally (BMJ Journal of Global Health) * Meeting People Where They Are: Scientist-Creators Delivering Trusted Health Information on Social Media and Beyond (The Evidence Collective) * Vaccine Integrity Project, The Evidence Collective announce projects to improve vaccine policy, restore trust (CIDRAP) * Outbreak of Legionnaires’ Disease Associated with Cooling Tower Systems in Central Harlem (NEJM Evidence) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * France confirms first Ebola case (BBC) * Hantavirusdashboard (Hantavirus.up) * Hantavirus on board with Prof. VincentRacaniello (microbeTV) * Health agencies signal end of quarantine period for cruise-linked Andes virus outbreak (DG:Alerts) * HHS Successfully Concludes Hantavirus Response Effort; Monitoring Ends with No Positive U.S. Case (US: HHS) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * US measles cases continue to climb, especially in Virginia (CIDRAP) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Measles Outbreak in Cook County, Illinois, September–October 2025 (NEJM Evidence) * CDC ‘transitioning away’ from diagnostic testing for measles, mumps (POLITICO PRO) * CIDRAP Op-Ed: Call it what it is—the US has lost its hold on measles elimination (CIDRAP) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * US military requires flu vaccine for some after outbreak in Texas training center (Reuters) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * CDC’s chief blocked a covid vaccine study. Now it’s in a top medical journal. (Washington Post) * Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design (JAMA Network: OPEN) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1334 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection.
Hosts: VVincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Bundibugyo ebolavirus sitrep (WHO) * Ebolavirus and Andes virus with John Dye (TWiV Special) * Major research nonhuman primate supplier going out of business (Science) * HIV-1 signalling remodels nuclear pores to licence infection (Nature) * STING agonist nanoparticles enable mucosal-systemic immunity (Nature Nanoparticles) * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Brianne – Otherworldly music albums feature space weather data Rich – Evidence Mapping: Consolidating and summarising available evidence to support the demonstration of effectiveness of developmental vaccines, Australian Living Evidence Collaboration (ALEC) Alan – Holyoke dam fish elevator Vincent – 68 Quadrillion Underground Miles of Fungi
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent travels to ASM Microbe in Washington DC to speak with John Dye of the United States Army Medical Research Institute of Infectious Diseases about the recent outbreaks of Bundibugyo ebolavirus in Africa and Andes virus on a cruise ship.
Host: Vincent Racaniello Guest: John Dye
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello express concern about vaccine policy and ACIP, scaling back of the CDC’s role in global public health, shingles vaccine and dementia, new screwworm cases, the Ebola outbreak in the Congo and Uganda and where the hantavirus outbreak began, before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, Virgina outbreak of measles, how to access and pay for Paxlovid, how more people were negatively impacted by influenza than COVID, discontinuing contact precautions for COVID, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Today we filed a motion asking the First Circuit to expedite our appeal of the district court’s order in the AAP lawsuit that left ACIP—the nation’s vaccine advisory committee—without a quorum (X) * CDC advisers drop decades-old universal hepatitis B birth dose recommendation, suggest blood testing after 1 dose (CIDRAP) * HHS asks for expedited appeal of court ruling on US vaccine policy (CIDRAP) * New Plan Scales Back C.D.C.’s Work on Diseases Abroad (NY Times) * Zoster Vaccination and Dementia: Interpreting the Signal and Testing the Mechanisms (CID) * Safety and Immunogenicity of 1 or 2 Additional Doses of the Adjuvanted Recombinant Zoster Vaccine Administered 5–6 Years After Primary Vaccination in Adults ≥50 Years (OFID) * Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) * CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) * Head-to-head comparison suggests flu was much more likely to lead to hospitalization than COVID last winter (CIDRAP) * FDA Issues Emergency Use Authorization for Generic Over-the-Counter Drug to Treat New World Screwworm in Dogs and Cats (FDA) * Fact Sheet: Emergency Use Authorization of Nitenpyram Tablets (nitenpyram) for New World Screwworm (NWS) (FDA) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * Big Ebola outbreak puts spotlight on little known virus (Science) * Ebola outbreak spreads to crowded displacement camp in Congo (Reuters) * Ebola outbreak in DR Congo expands into large displacement camp (CIDRAP) * Congo Ebola outbreak may be worst ever, Africa CDC says (Reuters) * Advocacy groups are urging the release of the monoclonal antibody MBP134 and any other requested investigational therapeutics (Citizen.org) * Hantavirus dashboard (Hantavirus.up * Hantavirus on board with Prof. Vincent Racaniello (microbeTV) * How did the cruise ship hantavirus outbreak start? (Science) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard( South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * US measles cases continue to climb, especially in Virginia(CIDRAP) * Measles (VDH: Virginia Department of Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Anguished Parents, Crying Doctors: Life Amid Utah’s Measles Outbreak (Wired) * Characteristics of Patients Hospitalized with Measles During an Outbreak — West Texas, January–March 2025 (CDC:MMWR) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * Influenza Vaccine and Associated Infection and Death in California, 2024 to 2025 (JAMA Network OPEN) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Seasonal influenza versus COVID-19 hospitalisation risk during the 2025–26 influenza season (LANCET: Infectious Diseases) * Discontinuingcontact precautions for COVID-19: the science says its time (Infection Control and Hospital Epidemiology) * 2024-2025 COVID-19 Vaccine and Major Adverse Cardiovascular Events Among US Veterans (JAMA Internal Medicine) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia University Irving Medical Center) * The answers: Long COVID Reaching out to US house representative * Letters read on TWiV 1332 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research showing that dairy cows are infected with low doses of influenza A(H5N1) and do not transmit efficiently to other animals, and covalent inhibitors of human papillomavirus type 16 E6 protein that restore p53 function and suppress growth of HPV-driven tumors in vivo.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Letter on Baric funding ban (Science, scroll to bottom) * New political jobs at science agencies (Science) * Ebola sitrep (WHO) * Influenza H5N1 infection of dairy cows (Nat Comm) * Drug for cervical cancer (PNAS) * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Angela – SpaceX Brianne – Honeybees and shrimp are now getting vaccinated Rich – “Carrying the Fire: An Astronaut’s Journeys” by Michael Collins Vincent – NTSB Reveals What Really Happened to United 169
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello opine on the recent executive order on the routine childhood vaccination schedule, the Ebola outbreak in the Congo and Uganda including the fast track trials for 2 vaccine candidates and antivirals, recent Hantavirus infections, use of quarantined “Hantavirus” patients for the governmental propaganda machine, use of ribavirin and other antivirals for Hantavirus associated cardiopulmonary disease, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the measles outbreak in Bangladesh, as well as in a daycare center in Texas in 2025, how to access and pay for Paxlovid, FDA approval of a second COVID-19 antiviral drug, where to go for answers about long COVID-19, use of convalescent sera for COVID-19 treatment and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Childhood Vaccine Hesitancy (NEJM) * One Year In: Public Views of a Changing Public Health Landscape (Harvard School of Public Health) * Rotavirus Vaccine Coverage and Potential Barriers Among US Children Born From 2007 to 2024 (Pediatrics) * Texas reports New World screwworm in 3-week-old calf (CIDRAP) * USDA Confirms First Case of New World Screwworm in a Dog in Lea County, New Mexico, Fourth Case in Texas (USDA: Animal and Plant Health Inspection Service) * Confirmed Detections of New World Screwworm (USDA: Animal and Plant Health Inspection Service) * Mexico reports more human New World screwworm infections (CIDRAP) * Frequency and persistence of post-acute symptoms after chikungunya, dengue, Zika and malaria in travellers: a prospective multi-centre study (Journal of Travel Medicine) * Ebola dashboard (ebola.fyi) * EBOLA:The Democratic Republic of the Congo, 2026 (WHO) * Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * Modeled Scenario Projections for the Ebola Disease Outbreak Caused by Bundibugyo Virus, 2026 (CDC: MMWR) * Assessment of Riskto the U.S. Population from the Ebola Disease Outbreak Caused by Bundibugyo Virus, 2026 (CDC: MMWR) * How Ebola Disease Spreads (CDC: Ebola) * Signs and Symptoms of Ebola Disease (CDC: Ebola) * Hantavirusdashboard (Hantavirus.up) * Hantavirus on board with Prof. VincentRacaniello (MicrobeTV) * Some hantavirus-exposed cruise ship passengers return home to finish quarantine (CNN) * Use of tocilizumab for severe hantavirus pulmonary syndrome: a MEURI case series with contextual comparisons (LANCET: Infectious Diseases) * First reported case of Andes hantavirus cardiopulmonary syndrome treated with a combination of favipiravir, ribavirin, icatibant and baricitinib (Clinical Microbiology and Infection) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Anguished Parents, Crying Doctors: Life Amid Utah’s Measles Outbreak (Wired) * Characteristics of Patients Hospitalized with Measles During an Outbreak — West Texas, January–March 2025 (CDC:MMWR) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Real-world emergence of nirsevimab resistance in breakthrough infections with respiratory syncytial virus-B: a multicentre observational study in France (LANCET: Microbe) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national andregional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Shionogi Announces FDA Approval of XOCOVA® (ensitrelvir), the First and Only Oral Option to Help Prevent COVID-19 Following Exposure (Businesswire) * SARS-CoV-2 viral shedding and vaccination‑modified effects of oral antivirals in older COVID-19 patients: a retrospective cohort study in Hong Kong (International Journal of Infectious Diseases) * SARS-CoV-2 vaccination and attenuation of breakthrough infection severity: A systematic global review and meta-analysis (CID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Metformin on the Presence of COVID-19 Symptoms 6 Months after Infection: The ACTIV-6 Randomized Clinical Trial (CID) Reaching out to US house representative * Letters read on TWiV 1330 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research showing limited transmission of cervid prions to nonhuman primates, and the finding that cone-shaped HIV-1 capsids are transported through intact nuclear pores.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Ebola outbreak news (ECDC, WHO) * NSF research grants on hold (Nature) * Transmission of cervid prions to nonhuman primates (Sci Adv) * Cone-shaped HIV-1 capsids transported intact through nuclear pore (Cell) * HIV-1 reproduction video (Janet Iwasa) * Letters read on TWiV 1329 * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Brianne – What We Need to do NEXT Re: OMB Rule Alan – Metallic Realms, by Lincoln Michel Vincent – TWiV 1: West Nile Virus
Listener Picks Mark – How the Library of Congress packed 250 years of U.S. history into a vial the size of a quarter
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello opine on the recent executive order on the routine childhood vaccination schedule, the Ebola outbreak in the Congo and Uganda including the fast track trials for 2 vaccine candidates and antivirals, recent Hantavirus infections, use of quarantined “Hantavirus” patients for the governmental propaganda machine, use of ribavirin and other antivirals for Hantavirus associated cardiopulmonary disease, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the measles outbreak in Bangladesh, as well as in a daycare center in Texas in 2025, how to access and pay for Paxlovid, FDA approval of a second COVID-19 antiviral drug, where to go for answers about long COVID-19, use of convalescent sera for COVID-19 treatment and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * CIDRAP Op-Ed: What’s the likely next move after the executive order on childhood vaccines? (CIDRAP) * Ebola dashboard (ebola.fyi) * Epidemic of Ebola Disease caused by Bundibugyo virus in the Democratic Republic of the Congo and Uganda determined a public health emergency of international concern (WHO) * WHO ramps up support to the Democratic Republic of the Congo’s Ebola outbreak response (WHO: Democratic Republic of Congo) * Ebola Outbreak: Current Situation (CDC:Ebola) * Race begins to trial Ebola drugs amid current outbreak (Nature) * Three Ebola vaccine candidates fast-tracked as African outbreak continues (CIDRAP) * CEPI fast-tracks three Bundibugyo ebolavirus vaccine candidates (CEPI) * Obeldesivir (Wikipedia) * Hantavirusdashboard (Hantavirus.up) * Hantavirus on board with Prof. VincentRacaniello (microbeTV) * Scoop: HHS asks confined hantavirus cruise passengers to assist in propaganda (Inside Medicine) * Ribavirin (DrugBank) * First reported case of Andes hantavirus cardiopulmonary syndrome treated with a combination of favipiravir, ribavirin, icatibant and baricitinib (Clinical Microbiology and Infection) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (IDSA) * Deaths following vaccination: what does the evidence show (Vaccine) * Bangladesh posts more than 1,300 measles cases, 2 deaths, in 1 day (CIDRAP) * Measles Outbreak in a Child Care Facility — Lubbock, Texas, March–April 2025 (CDC:MMWR) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Shionogi Announces FDA Approval of XOCOVA® (ensitrelvir), the First and Only Oral Option to Help Prevent COVID-19 FollowingExposure (Businesswire) * FDA Approves Oral Antiviral to Prevent COVID-19 After Exposure (MEDPAGE TODAY) * The impact of COVID-19 vaccination on long-term risk of new-onset atrial fibrillation/flutter after COVID-19 infection: A retrospective cohort study (PLoS One) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall (microbeTV) * COVID-19 L*OVE: the largest open repository of evidence on this pandemic (Epistemonikos) * Convalescent plasma for people with COVID‐19 (Cochrane Library) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1328 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains research on human influenza virus transmission that reveals heterogeneous expulsion of infectious virus into air, and how gut bacteriophages dictate inflammation heterogeneity through tuning the phage-bacteria-sphingosine-intestine axis in Crohn’s disease.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * NIH ousts infectious-disease leaders (Nature) * Measles deaths in Bangladesh (npr) * Russel Vought is going to destroy American science (Elizabeth Ginexi) * Heterogeneous expulsion of infectious influenza virus into air (Cell) * Gut phages and Crohn’s disease (Cell Host Microbe) * MIST device (Emory) * Letters read on TWiV 1327 * Timestamps by Jolene Ramsey. Thanks!
Picks of the Week Brianne – The Perfect Bee Language Rich – Hubble’s Messier Catalog Jolene – A different kind of power – Jacinda Ardern Vincent – Albert Sabin by Karen Torghele
Listener Picks Anthony – Dr. Dakotah Tyler Marcus – Apollo
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello comment on incidences of locally transmitted malaria in the US, mpox diagnostics, the latest developments surrounding hantavirus infections, and the Ebola outbreak in the Congo and Uganda including vaccine candidates before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the measles outbreak in Texas in 2025, how to access and pay for Paxlovid, where to go for answers about long COVID-19, casual association of auto-antibodies and COVID complications and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * CDC Operational Guidance for Investigating Locally Acquired Mosquito-Transmitted Malaria — United States, 2026 (CDC: MMWR) * Performance of five mpox antigen-based rapid diagnostic tests tested on lesion swabs from patients with suspected mpox from the Kinshasa province of DR Congo: a diagnostic accuracy study (LANCET: Infectious Diseases) * Hantavirusdashboard (Hantavirus.up) * Andes Hantavirus Outbreak on a Cruise Ship, 2026 (NEJM) * “Super-Spreaders” and Person-to-Person Transmission of Andes Virus in Argentina (NEJM) * Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014 (CDC: Emerging Infectious Diseases) * Hantavirus on board with Prof. VincentRacaniello (microbeTV) * Ebola dashboard (ebola.fyi) * Epidemic of Ebola Disease caused by Bundibugyo virus in the Democratic Republic of the Congo and Uganda determined a public health emergency of international concern (WHO) * WHO ramps up support to the Democratic Republic of the Congo’s Ebola outbreak response (WHO: Democratic Republic of Congo) * WHO chief says fast-moving Ebola epidemic is outpacing response efforts (Reuters) * US CDC seeks staff for Ebola screening as outbreak response expands (Reuters) * Trump Administration to Send Americans Exposed to Ebola to Kenya (NY Times) * Single Immunization With a Monovalent Vesicular Stomatitis Virus–Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus (JID) * Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus (PLoS Neglected Tropical Diseases) * Vaccine experts debate options to combat outbreak of unusual Ebola strain (Science) * NIAID Establishes Centers for Research in Emerging Infectious Diseases (NIAID.NIH) * Inside the Race to Develop a Test for the Rare Andes Hantavirus (Wired) * NIH terminates network aimed at stopping pandemics before they start (Science) * These Researchers Would Be in Africa Fighting Ebola—but Trump Cut Their Funding (Wired) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Characteristics of Patients Hospitalized with Measles During an Outbreak — West Texas, January–March 2025 (CDC:MMWR) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * US FDA advisers to weigh updating 2026-27 COVID vaccines for XFG variant (Reuters) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * A causallink between autoantibodies and neurological symptoms in long COVID (Cell) * Reaching out to US house representative * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent travels to Oregon State University in Corvallis to meet up with Hannah Rowe to talk about her career and her work demonstrating how the interaction of influenza A virus and Streptococcus pneumonia influences transmission.
Hosts: Vincent Racaniello Guest: Hannah Rowe
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Respiratory bacteria stabilize influenza A virus (mSystems) * S. pneumoniae and influenza A virus binding (mSphere) * Bacterial alteration of redox stressors and stability of influenza A virus (mSphere) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss withdrawal of the ACIP charter published in April 2026, the first council meeting on antibiotic resistant bacteria, the latest developments surrounding hantavirus infections, and the Ebola outbreak in the Congo and Uganda before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, transmission of SARS-CoV-2 through the air including ventilation systems, how to access and pay for Paxlovid, where to go for answers about long COVID-19, early use of antiviral drugs for COVID-19 patients and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * US health department withdraws vaccine advisory panel charter (Reuters) * Meeting of the Presidential Advisory Council on Combating Antibiotic-Resistant * Bacteria (Federal Register) * Andes Hantavirus Outbreak on a Cruise Ship, 2026 (NEJM) * “Super-Spreaders” and Person-to-Person Transmission of Andes Virus in Argentina (NEJM) * Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014 (CDC: Emerging Infectious Diseases) * Hantavirus on board with Prof. VincentRacaniello (microbeTV) * Hantavirus Doesn’t Spread Easily, but Officials May Be Downplaying Risks (NY Times) * Cross-binding antibodies capable of neutralising diverse hantaviruses are produced in response to Puumala virus infection (eBioMedicine) * Hantavirus dashboard (Hantavirus.live) * Visualizing the hantavirus cruise outbreak in maps and charts (CNN) * Epidemic of Ebola Disease caused by Bundibugyo virus in the Democratic Republic of the Congo and Uganda determined a public health emergency of international concern (WHO) * Ebola outbreak response intensifies in DRC and Uganda as cases mount (DG: Alerts) * WHO ramps up support to the Democratic Republic of the Congo’s Ebola outbreak response (WHO: Democratic Republic of Congo) * Vaccine experts debate options to combat outbreak of unusual Ebola strain (Science) * US promises to fund clinic established to treat Ebola (X-USForeignAssist) * U.S.-Bound Flight Diverted to Canada Because of Ebola Restrictions (NY Times) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Maternal RSV Vaccination, Infant Nirsevimab, or Both: Interim Analysis of a Randomized Trial (Pediatrics) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Potential airborne transmission of SARS-COV-2 through bathroom ventilation ducts associated with an outbreak in a residential building in Santander, Spain, 2020 (PLoS One) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * Recent COVID-19 Vaccination and Risk of SARS-CoV-2 Transmission (JAMA Network OPEN) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Early antiviral use may lower risk of long COVID in mildly ill patients, aid recovery from infection (CIDRAP) * Early-Phase Oral Antiviral Use and Post–COVID-19 Condition in Outpatients (JAMA Network OPEN) * Impact of Early Oral Antiviral Use for Outpatients With COVID-19 on Healthcare Utilization and Recovery (ANCHOR-02) (International Journal of Infectious Diseases) Reaching out to US house representative * Letters read on TWiV 1324 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines, and how toll-like receptor 7 alters the maternal immune landscape during influenza A infection to increase maternal and fetal morbidity,
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * RFK Jr. driving vast inquiry into vaccines (NY Times) * Indiana plant biologist locked out of lab by school (Science) * Trump cuts CDC role in PEPFAR (Science) * Ralph Baric retires (The Assembly) * Baric to fight NIH funding ban (Science) * Ebola outbreak in DRC (npr) * Persistence of Andes virus RNA in human semen (Viruses) * mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines (Cell Rep) * Science will break your heart (TWiV 920) * TLR7 and maternal and fetal morbidity during influenza (Sci Adv) * Letters read on TWiV 1323 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Kathy –Bloomberg Connects app and What’s in Bloom Peony Season 2026 Bloom Tracker Rich – Medpage Today: What you need to know about hantavirus Vincent – Apollo 11 Almost Never Left the Moon
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Daniel Griffin and Vincent Racaniello reviewed the latest developments surrounding the hantavirus outbreak, including new interim guidance from the Centers for Disease Control and Prevention for the management of infectious cases, whether the CDC may be downplaying the significance of the outbreak because of public backlash following the COVID-19 pandemic, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, benefit of maternal vaccination against RSV for infants, efficacy and safety of a mRNA influenza vaccine how to access and pay for Paxlovid, where to go for answers about long COVID-19, multisystem inflammatory syndrome in children and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Interim Guidance for Public Health Assessment and Management of People with Potential Exposure to Andes Virus Outbreak (CDC) * Hantavirus in humans: a review of clinical aspects and management (LANCET: Infectious Diseases) * “Super-Spreaders” and Person-to-Person Transmission of Andes Virus in Argentina (NEJM) * Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014 (CDC: Emerging Infectious Diseases) * Hantavirus on board with Prof. Vincent Racaniello (microbeTV) * Transcript – Updateon CDC’s Hantavirus Response 5/13/2026 (CDC) * CDC Is Walking a Tightrope With Its Response to Hantavirus (Wall Street Journal) * What Happened on the Hantavirus Cruise, According to a Doctor On Board (The Atlantic) * Andes hantavirus outbreak on a cruise ship – an ESCMID Emerging Infections Subcommittee (EIS) rapid assessment (CMI: Clinical Microbiology and Infection) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults (NEJM) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Maternal RSV Vaccination, Infant Nirsevimab, or Both: Interim Analysis of a Randomized Trial (Pediatrics) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Life lost due to the COVID-19 pandemic: A model-based cohort analysis of mortality displacement in the registered population of England (PLoS One) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts (NEJM) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1322 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains how cross-reactive anti-prophage antibodies and bacterial heteroresistance is implicated in phage therapeutic failure, and how phages communicate across species to shape microbial ecosystems.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Craig Venter dies (Nature) * Hantavirus outbreak (WHO) * Hantavirus on board (YouTube) * HPS 25th anniversary discovery story (EID) * Phage therapeutic failure unraveled (Nat Med) * Phages communicate across species (Cell) * Control of lysis-lysogeny decisions (Trends Micro) * Arbitrium phages manipulate each other (Cell) * Elio Schaechter on arbitrium (TWiM 146) * Letters read on TWiV 1321 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Could this fungus contaminate Mars? Rich – Supernova in a Sideways Spiral Jolene – Virology class communication projects 2026 Vincent – Facts About The Boeing 747 Hump That Will Surprise You
Listener Picks David – My first science video in 3 years Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the outbreak of Hantavirus on a cruise ship and its potential for person-person transmission, how cessation of funding for global health by the Trump administration has compromised American health and well being, as well as the description of paralytic poliomyelitis outbreaks in Central Africa associated with the administration of nOPV2, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, association of ear infections in children with RSV, PEMGARDA authorized use for certain immunocompromised individuals where to find PEMGARDA, how to access and pay for Paxlovid, where to go for answers about long COVID-19, multisystem inflammatory syndrome in children and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Hantavirus Pulmonary Syndrome—The 25th Anniversary of the Four Corners Outbreak (CDC: Emerging Infectious Diseases) * Outbreak of Hantavirus Infection in the Four Corners Region of the United States in the Wake of the 1997–1998 El Nino—Southern Oscillation (JID) * Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014 (CDC: Emerging Infectious Diseases) * Hantavirus cluster linked to cruise ship travel, Multi-country (WHO) * Hantavirus (WHO) * Ventilation Upgrade Reduces Fuel Consumption by 10 Percent in Cruise Ships(Halton) * Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014 (CDC: Emerging Infectious Diseases) * Incubation Period of Hantavirus Cardiopulmonary Syndrome (CDC: Emerging Infectious Diseases) * At least 8 sickened in suspected hantavirus outbreak; Andes strain confirmed * (CIDRAP) * Hantavirus in humans: a review of clinical aspects and management (LANCET: Infectious Diseases) * Cruise ship’s hantavirus outbreak puts researchers in uncharted territory (Science) * Hantavirus Response Shows How Trump Cuts Have Compromised U.S. Preparedness (NY Times) * Hantavirus on board with Prof. Vincent Racaniello (microbeTV) * Emergence of vaccine-derived poliovirus strains from the novel oral polio vaccine in the Central African Republic (mBio) * TWiV 1319: An earful of SARS-CoV-2 (microbeTV) * Poliomyelitis (polio) (WHO) * The world’s largest and highest-quality first-party data company (Dynata) * MMR vaccine hesitancy in a polarized information ecosystem: Results from a cross-sectional survey of US adults (Vaccine) * CDC communication undermines trust in vaccines (Science) * F.D.A. Blocked Publication of Research Finding Covid and Shingles Vaccines Were Safe (NY Times) * Tick Bite Data Tracker (CDC: Ticks) * Infectious Diseases (POPHIVE: Yale School of Public Health) * The National Respiratory and Enteric VirusSurveillance System (NREVSS) (CDC: National Respiratory and enteric virus surveillance System) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Will the USA lose its measles elimination status? (LANCET) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Impact of Respiratory Syncytial Virus Immunization on the Rate of Pediatric Acute Otitis Media: A Time-series Analysis (CID) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Multisystem inflammatory syndrome in children (MIS-C), United States, 2023–2024 (CID) * Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID (Communications Medicine) * Reaching out to US house representative * Letters read on TWiV 1320 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains the emergence of vaccine-derived poliovirus strains from the novel oral polio vaccine in the Central African Republic, and the infection of spiral ganglion neurons in the inner ear by SARS-CoV-2, which may explain hearing loss in humans.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Bernard Roizman dies (U Chicago) * Craig Venter dies (Sci Am) * Trump fires National Science Board (AAU) * It was World Vaccine Week (WHO) * nOPV2 phenotypically reverts via recombination (mBio) * SARS-CoV-2 infects inner ear (Cell Rep) * Letters read on TWiV 1319 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Kathy – Science of rats and other organisms in the East River Alan – Chronolog citizen science project Vincent – Why Do Train Engines Sometimes Face Backwards?
Listener Picks Chris – Consensus: AI for research Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello note the uncertain future of the National Science Foundation amid shifting U.S. funding priorities and governance; the rise of China as a global research powerhouse; ongoing advances and controversies in vaccines shaped by the World Health Organization and the Centers for Disease Control and Prevention; vaccine policy battles in Florida; European approval of the moderna mCOMBRIAX, COVID-19 and influenza vaccine, the mounting evidence supporting preventive vaccination strategies including that for HPV and the HepB birth dose; the spread of drug-resistant infections and the resurgence of HIV in Zambia; and the enduring public trust in scientists despite political turbulence, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the efficacy of the influenza vaccine for children, PEMGARDA authorized use for certain immunocompromised individuals where to find PEMGARDA, how to access and pay for Paxlovid, use of remdesivir for RSV, how administration of Paxlovid did not affect hospitalization of high-risk vaccinated patients, where to go for answers about long COVID-19, if SARS-CoV-2 infection may facilitate EBV reactivation, exercise for treating long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Entire NSF science advisory board fired by Trump administration (Nature) * United States v. Arthrex, Inc.(Harvard Law Review) * United States v. Arthrex Inc. [SCOTUSbrief] (Federalist Society) * China could be the world’s biggest public funder of science within two years (Nature) * The Vaccine Skeptic in Trump’s New C.D.C. Leadership Team (NY Times) * World Immunization week: Largest catch-up initiative delivers over 100 million childhood vaccinations (WHO) * Pigs are flying!: Florida Republicans refuse to take up DeSantis bill loosening vaccine mandates (NY Times) * Moderna Receives European Commission Marketing Authorization for mCOMBRIAX, Moderna’s mRNA Combination Vaccine Against Influenza and COVID-19(moderna) * America First! AIDS Creeps Back in Parts of Zambia, a Year After U.S. Cuts to H.I.V. Assistance (NY Times) * Emergence of Extensively Drug-Resistant Shigellosis — United States, 2011–2023 (CDC: MMWR) * Scientists Esteemed by Public, with Vaccine Scientists Seen as Similar to Scientists in General (Annenberg: Public Policy Center, University of Pennsylvania) * RFK Jr. is holding up $600M in vaccines for poor countries (Politico) * Trump Withdraws Nomination of Casey Means for Surgeon General (NY Times) * What? Benefit of preventive strategies like vaccination? Incidence of human papillomavirus infections in women aged 27 years and older in the US: A federated data network study (International Journal of Infectious Diseases) * Economic Impact of Delaying the Infant Hepatitis B Vaccination Schedule (JAMA Pediatrics) * Impact of Removing the Universal Hepatitis B Birth-Dose Vaccination in the US (JAMA Pediatrics) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Dangers of measles infection (NY Times) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (Xofluza) * Influenza Vaccination Coverage Among Nursing Home Residents and Health Care Personnel — United States, 2024–25 Influenza Season (CDC: MMWR) * Pediatric Vaccine Effectiveness Against Influenza Hospitalization And Outpatient Visits: 2021–2024 (Pediatrics) * Influenza Vaccine Effectiveness in European Primary Care Pediatric Practices: 2022–2024 (Pediatrics) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Impact of universal nirsevimab prophylaxis in infants on hospital and primary care outcomes across two respiratory syncytial virus seasons in Galicia, Spain (NIRSE-GAL): a population-based prospective observational study (LANCET: Infectious Diseases) * First Report on Remdesivir Use for the Treatment of Respiratory Syncytial Virus in Five Allogeneic Hematopoietic Cell Transplant Recipients (JID) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients(NEJM) * Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir(NEJM) * Paxlovid doesn’t reduce hospitalization, death rates in vaccinated high-risk COVID outpatients, trial shows (CIDRAP) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia: Columbia University Irving Medical Center) * The answers: Long COVID * Acute COVID-19 is associated with altered CD8 T-cells indicative of impaired ability to control Epstein–Barr virus reactivation (Medical Microbiology and Immunology) * Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial (Journal of Cachexia, Sarcopenia and Muscle) * Reaching out to US house representative * Letters read on TWiV 1318 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains a study showing that viral DNA load in blood and saliva varied markedly with age, time of day season, sex, and depended on dozens of genetic loci, and identification of an emerging human eye disease associated with aquatic virus zoonotic infection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * DNA virome varies with human genes and environments (Nature) * Emerging eye infection from aquatic virus (Nat Micro) * Letters read on TWiV 1317 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Wayback Machine: Internet Archive Rich – Grandparents for Vaccines Alan – On Writing by Stephen King Vincent –The Real Reason The Soviets Lost The Space Race!
Listener Picks Ginny – Dr. Cal Your Science Pal Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello are distressed by RFK Jr’s testimony in front of Congress, surges in rotavirus infections and the staggering number of people who believe in unproven claims about vaccines and science, before Dr. Griffin then deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the fatal consequences of measles infection, prevalence of influenza and other respiratory infections in dead people, PEMGARDA authorized use for certain immunocompromised individuals where to find PEMGARDA, how to access and pay for Paxlovid, results from a human RSV challenge study, where to go for answers about long COVID-19, negatively associated school-related outcomes in children and adolescents with long COVID, and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Kennedy denies being sidelined by the White House (Politico) * Kennedy continued to back away from his criticismof the measles vaccine (NY Times) * Rotavirus surges after ACIP removes recommendation for vaccine(Discovermagazine) * ‘Staggering’ number of people believe unproven claims about vaccines, raw milk and more (Nature) * Health is confronting division, confusion, and competing influences (Edelman) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Dangersof measles infection (NY Times) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots(CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * Prevalenceof influenza and other respiratory viral infections in deceased persons: a population-based observational study over four influenza seasons (Clinical Microbiology and Infection) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Maternal RSV vaccination and reduced risk of hospitalisation for babies in England, 2024/25 (ESCMID) * Viral dynamics of the Respiratory Syncytial Virus during experimental human challenge: insights for transmission and protection(JID) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Clinical and economic benefits of seasonal COVID-19 vaccination in Germany: results from the ROUTINE-COV19 Study, September 2022 to March 2024 (Eurosurveillance) * Effectiveness and safety of molnupiravir among patients with mild to moderate COVID-19: a prospective, observational, cohort study (Scientific Reports) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding CoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Divergent inflammatory and neurology-related protein levels in long COVID following primary and breakthrough SARS-CoV-2 infections (Communications Medicine) * School Difficulties and Long COVID in Children and Adolescents (Academic Pediatrics) * Reaching out to US house representative * Letters read on TWiV 1316 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains a study showing that the wildlife trade, including live-animal markets, is a major driver of animal-to-human pathogen transmission, and ecological vaccination, a strategy to prevent zoonotic spillover from bats.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Bernard Roizman passes (Wikipedia) * Maturation of a scientist (Ann Rev Virology) * Wildlife trade drives pathogen transmission (Science) * Ecological vaccination of bats (Sci Adv) * Letters read on TWiV 1315 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Real-time tracking of pathogen evolution Rich – A Precarious Perch; Suwannee’s track; Avian Research and Conservation Institute Alan – Bookshop.org Vincent – The Mysterious 30 Year Journey of Apollo 12
Listener Picks Fernando – Sean M. Carroll’s series “The Biggest Ideas in the Universe”: “Space, Time, and Motion”, and “Quanta and Fields.” Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV 1314: Clinical update with Dr. Daniel Griffin April 17, 2026 In his weekly clinical update, Dr. Griffin and Vincent Racaniello are dismayed but not surprised by poll results suggesting most Americans doubt vaccine safety, that the head of the CDC and NIH delayed release of a report on the safety of the COVID-19m vaccine, how Nature works to spread disease without the help of the lab and the about face of the Trump administration to nominate a pro-vaccine candidate for CDC director, before Dr. Griffin then deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how the influenza vaccine may attenuate stroke and acute cardiac disease following virus infection, PEMGARDA authorized use for certain immunocompromised individuals where to find PEMGARDA, how to access and pay for Paxlovid, how the COVID-19 pandemic was a ‘negative’ for one’s mortality where to go for answers about long COVID-19, potential therapies for the pediatric long COVID population and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * More Americans doubt vaccine safety than trust it, POLITICO Poll finds (Politico) * Top C.D.C. Official Delays Report on Covid Shot’s Effectiveness (NY Times) * Vampire bats in Mexico may feed on CWD-positive deer, spreading disease and posing species-jump threat (CIDRAP) * Emerging risks at the vampire bat–prion interface: implications for wildlife, livestock, and public health (Journal of Mammalogy) * Nine-Valent Human Papillomavirus Vaccination and Related Cancers in Males (JAMA: Oncology) * Trump Administration Eyes Erica Schwartz to Lead CDC (Wall Street Journal) * Trump to Nominate Doctor Who Has Publicly Supported Vaccines as C.D.C. Director (NY Times) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Measles vaccine recommendations from NYP (jpg) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots(CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots(CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * Influenza vaccination attenuates acute myocardial infarction and stroke risk following influenza infection: a register-based, self-controlled case series study, Denmark, 2014 to 2025 (Eurosurveillance) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Deep disadvantage in mortality on the frontlines of the COVID-19 pandemic (Scientific Reports) * Potter’s Field (Wikipedia) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Interdisciplinary Pediatric Long-COVID Care: A Descriptive Study of Interventions and Health-Related Quality of Life (OFID) * Reaching out to US house representative * Letters read on TWiV 1314 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews evidence that influenza standard and high-dose vaccines reduce risk of Alzheimer’s dementia, and spread of deltaviruses by a viral Trojan horse mechanism.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Dennis O’Callaghan passes (Wikipedia, LSU) * Reduced dementia risk after influenza vaccine (Neurology) * Deltaviruses spread via Trojan Horse (Cell) * Letters read on TWiV 1313 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Rich – The Path of Artemis II Alan – Climate change is causing cherry blossoms to miss their peak blooms in Japan Vincent – The Fabric of the Cosmos: Space, Time, and the Texture of Reality by Brian Greene
Listener Picks Ann – Artemis II Launch – 7.5 Seconds in Slo-Mo Torsten – ‘This feels fragile’: how a satellite-smashing chain reaction could spiral out of control Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello are aghast at the CDC’s decision to no longer test for rabies and mpox and the revised charter for its the advisory committee on immunization practices, an outbreak of E. coli illness in raw cheese, before Dr. Griffin then deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, clinical practice guidelines for treating COVID-19, PEMGARDA authorized use for certain immunocompromised individuals where to find PEMGARDA, how to access and pay for Paxlovid, if the nasal microbiome modulates COVID-19 disease severity, reviews the use of steroid, antibiotics, anticoagulants and IVIG for treating COVID-19 including long COVID, and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * State public health labs step up as CDC pauses testing for various pathogens, including rabies, mpox (CIDRAP) * Infectious Diseases Laboratories : Test Directory (CDC) * Kennedy rewrites the rule for membership on US vaccine advisory panel (Reuters) * Advisory Committee on Immunization Practices (ACIP): ACIP charter (CDC) * Quick takes: More E coli tied to raw cheese, drug-resistant Shigella in UK, TB funds for Sudan (CIDRAP) * Voluntary Recall (FDA) * E. coli Outbreak Linked to Raw Dairy (CDC: E.coli Infection (Escherichia coli)) * We 100% disagree with the FDA’s false “possible link”, and extreme allegations (RawFarm USA) * Risk of Multiple Sclerosis Among Persons With Epstein-Barr Virus–Positive Mononucleosis(Neurology) * US Scientists Sequence 1,000 Genomes From Measles, a Disease Long Eliminated With Vaccines (KFF HealthNews) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19 (CID) * 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Baricitinib vs. Tocilizumab (CID) * ImmunobridgingAnalysis of Pemivibart for the Treatment of COVID-19 – A Therapeutic Gap for the Immune Compromised Remains (OFID) * PEMGARDA® is authorized for use in certain moderately to severely immunocompromised patients to help prevent COVID-19 (Pemgarda) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Association of nasopharyngeal Dolosigranulum pigrum and Corynebacterium species with post-acute sequelae of SARS-CoV-2 in a longitudinal cohort (Microbiology Spectrum) * The effect of corticosteroids, antibiotics, and anticoagulants on the development of post-COVID-19 syndrome in COVID-19 hospitalized patients 6 months after discharge: a retrospective follow up study (Clinical and Experimental Medicine) * Intravenous immunoglobulin treatment for long COVID: a case report of clinical and immunological findings (LANCET: Infectious Diseases) * Management of Orthostatic Hypotension (JAMA: Internal Medicine) Reaching out to US house representative * Letters read on TWiV 1312 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent visits the University of Kansas and speaks with Tony Fehr, Robin Orozco, Juergen Richt and Rob Unckless about their careers and the research ongoing in their laboratories.
Host: Vincent Racaniello Guests: Tony Fehr, Robin Orozco, Juergen Richt, and Rob Unckless
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Links for this episode * Support science education at MicrobeTV * PARP14 affects replication of multiple viruses (mBio) * PTPN22 allele enhances innate antiviral immunity (PNAS) * Disruption of influenza in gene edited pigs (Emerg Microbes Inf) * Drosophila innubila nudivirus (Virology) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello cover if the “five-second” rule for things that fall on the floor apply to surgical equipment, an outbreak of E. coli illness caused by raw cheese before Dr. Griffin then deep dives into the measles outbreak in South Carolina and Utah, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, strain selection for the 2026-2027 season influenza vaccine by the FDA, if standard or high dose influenza vaccination influences dementia protection, a new variant of SARS-CoV-2, how to access and pay for Paxlovid, specific effects of Paxlovid and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * The “five-second” rule for dropped food: does it apply to dropped medical objects in the operating room? A randomized study of disinfection approaches for contaminated arthroplasty implants (Infection Control & Hospital Epidemiology) * Whole Genome Sequencing (WGS) Program (FDA) * Outbreak Investigation of E. coli O157:H7: Raw Cheddar Cheese (March 2026) (FDA) * Wastewater for norovirus (WasterWater Scan) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) * Risk of Alzheimer Dementia After High-Dose vs Standard-Dose Influenza Vaccination (Neurology) * Weekly surveillance report: clift notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Respiratory viral infections prime accelerated lung cancer growth (Cell) * Early Detection and Surveillance of the SARS-CoV-2 Variant BA.3.2 — Worldwide, November 2024–February 2026 (CDC: MMWR) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Paxlovid shows organ-specific and age-specific impacts on risk of developing post-acute sequelae of COVID-19 (Communications Medicine) * The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID (Annals of Internal Medicine) * Reaching out to US house representative * Letters read on TWiV 1310 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains why human papillomavirus vaccine-induced immunity can block infection, unlike all other vaccines, and how respiratory viral infections such as COVID and influenza prime accelerated lung cancer growth.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * J. Michael Bishop passes (NY Times) * Vincent interviews JM Bishop (YouTube) * David Botstein passes (NY Times) * Post-attachment neutralization of HPV (npj vaccines) * HPV vaccine blocks infection (Cancer Discov) * Respiratory viral infections prime lung cancer growth (Cell) * Respiratory virus infections awaken metastatic breast cancer (TWiV 1243 ) * SARS-CoV-2 mRNA vaccines sensitize tumors to immunotherapy (TWiV 1265) * Letters read on TWiV 1309 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Project Hail Mary Rich – After a decade as a Yale hospital janitor, she is now a doctor there Alan – Scientific analysis of jokes in conference talks Vincent – Yuval Noah Harari: Why advanced societies fall for mass delusion
Listener Pick Greg – Changes in Terrestrial N Budgets and Riverine Nitrate-N Yields from Mississippi River Basin Watersheds 2000 to 2020 Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello talk about the resignation of a member of the advisory committee for immunization practices and the irony of his rationale that a judge slandered him, vaccinating dairy cattle against H5N1, illnesses resulting from drinking raw milk and the US norovirus outbreak, which is not cruise related, then Dr. Griffin deep dives into the measles outbreak in South Carolina and Utah, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, safety data of the RSV vaccine for high risk young adults, recognition of unrecognized COVID-19 deaths (but weren’t we not allow to call it a COVID-19 in 2020?), retraction of and how the ANTIBIOTIC azithromycin is NOT an antiviral drug, how to access and pay for Paxlovid, long COVID patients with neurocognitive symptoms and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Confusion abounds over future of US vaccine advisory committee (The Guardian) * Key Adviser Quits Federal Vaccine Panel (NY Times) * Vaccinate the vacca? …..Why We Must Vaccinate US Dairy Cattle Against HPAI H5N1(JID) * Largest Animal Health Emergency in US History Continues as HPAI Hits Indiana Hard (Hoosier AG Today) * Indiana: More than 350,000 birds killed in massive avian flu outbreak (CIDRAP) * 5 children receive E. Coli from raw milk; TN dairy farm responds (Local 3 News) * Quick takes: Measles spike in Utah, 5 kids ill from raw milk, CDC director uncertainty (CIDRAP) * Increasing Predominance of Norovirus GII.17 over GII.4, United States, 2022–2025 (Emerging Infectious Diseases) * Wastewater for norovirus (WasterWater Scan) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots(CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Immunogenicity and Safety of the AS01E-adjuvanted Respiratory Syncytial Virus (RSV) Prefusion F Protein Vaccine in Adults Aged 18–49 Years at Increased Risk of RSV Disease Compared with Adults Aged ≥60 Years (CID) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Respiratory viral infections prime accelerated lung cancer growth (Cell) * Association between COVID-19 vaccination and sudden death in apparently healthy younger individuals: A population-based case-control study (PLoS Medicine) * Applying machine learning to identify unrecognized COVID-19 deaths recorded as other causes of death in the United States (Science Advances) * RETRACTED work: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial (International Journal of Antimicrobial Agents) * Antibiotic used in COVID patients tied to increased signs of antibiotic resistance (CIDRAP) * Empiric azithromycin alters the upper respiratory microbiome and resistome without anti-inflammatory benefit in COVID-19 (Nature Microbiology) * COVID-19 mRNA Vaccination in Pregnancy and Risk of Infection in Early Childhood (Pediatrics) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Outcomes of Patients with Neurocognitive Symptoms Attending a Long COVID Clinic: A Longitudinal Cohort Study (Journal of General Internal Medicine) * Outcomes of Patients withNeurocognitive Symptoms Attending a Long COVID Clinic: A Longitudinal Cohort Study (Journal of General Internal Medicine) * Long COVID Treatment Guide (rthm) * Reaching out to US house representative * Letters read on TWiV 1308 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews the structural basis for Rep-mediated adeno-associated virus DNA genome packaging, how influenza virus-infected myeloid cells travel to the heart and infect cardiomyocytes, leading to IFN-fueled heart damage.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Robin Weiss passes (ICR) * Judge strikes down RFK Jr.’s vaccine policies (NYTimes) * How Rep protein packages AAV DNA (Cell Rep) * How influenza virus causes heart damage (Immunity) * Influenza virus hitches a cellular ride to the heart (Cell Host Microbe) * Letters read on TWiV 1307 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – The math of March Madness brackets Kathy – SpaceX launch plume, jellyfish APOD and Cleveland Meteor, map of meteorites fall and a doorbell cam photo Rich – After barista’s tips were stolen, strangers showed up with $900 Vincent – What Causes Gravitational Time Dilation? A Physical Explanation.
Listener Pick Charles – They’re Made Out Of Meat Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello chat about death of water fowl on Long Island, ‘renaming’ of the FDA adverse event monitoring system, lawsuits against RFK Jr and HHS for illegal changes in routine immunization practices, before Dr. Griffin deep dives into economic costs of not vaccinating against measles, the measles outbreak in South Carolina, Utah and ICE detention centers, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, expansion of the RSV vaccine licensure to include high risk yound adults, association between lung cancer and respiratory illnesses, how to access and pay for Paxlovid, effectiveness of vaccination or supplemental vitamin D to reduce the risk of long COVID, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Local waterfowl die-off likely caused by bird flu (The Suffolk Times) * East End officials respond as dead birds pile up on Long Island shorelines (news 12: Long Island) * FDA Adverse Event Monitoring System(AEMS)(FDA) * FDA Launches NewAdverse Event Look-Up Tool(FDA) * FDA announces AEMS, new adverse-event database to replace VAERS (CIDRAP) * US cuts broad recommendation for four childhood vaccines including flu (Reuters) * US CDC deploys staff to curb South Carolina’s measles outbreak (Reuters) * US judge upends Kennedy’s overhaul of childhood vaccine policies (Reuters) * American Academy of Pediatrics, et al v. Robert F Kennedy, Jr, et al (Civil Action No 25-11916-BEM) * White House Puts RFK Jr.’s HHS on Tighter Leash After MAHA Setbacks(Wall Street Journal) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots(CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * FDA expands approval for RSV vaccine to include younger adults at high risk (FDA) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Respiratory viral infections prime accelerated lung cancer growth (Cell) * 2024–2025 COVID-19 mRNA Vaccine Effectiveness Against Severe Disease (JID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Effectiveness of COVID-19 Vaccination and Prior Infections to Reduce Long COVID Risk During the Pre-Omicron and Omicron Periods (CID) * A Randomized Trial of Vitamin D Supplementation and COVID-19 Clinical Outcomes and Long COVID: The Vitamin D for COVID-19 Trial (The Journal of Nutrition) * Long COVID Treatment Guide (rthm) * Reaching out to US house representative * Letters read on TWiV 1306 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV introduces sunshine virus of carpet pythons and its effect snakes after experimental infection, and development of a new tool to distinguish between naturally ocurring outbreaks and those that arise from lab accidents.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * IgNobel Prize ceremony moved to Europe (Science) * Prasad is out of the FDA (again) (npr) * Sunshine virus in carpet pythons (J Virol) * Selection preceding epidemics and pandemics (Cell) * Letter read on TWiV 1305 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne –Galileo’s handwritten notes found in ancient astronomy text Rich – Dungeon Crawler Carl by Matt Dinniman Alan – High-resolution 3D imaging of the USS Monitor by NOAA’s new µSAS system Vincent – The Order of Time by Carlo Rovelli
Listener Pick Douglas –Grandparents for vaccines Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the global spread of the ‘eradicated’ poliovirus, the suggestion of RFK’s autocratic ability to change vaccine policy and the ‘resignation’ for the second time of CBER director Vinjay Prasad, and zoonotic spillover of viruses without adaptation, before Dr. Griffin deep dives into economic costs of not vaccinating against measles, the measles outbreak in South Carolina, Utah and ICE detention centers, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, VRPBEC meeting for ‘flu’ vaccine strain selection, how to access and pay for Paxlovid, closing of long COVID treatment centers globally, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Polio: Practice enhanced precautions…..but isn’t it eradicated? (CDC: Travelers’ Health) * RFK Jr has ‘unreviewable‘ authority to reshape vaccine policy, DOJ lawyer tells judge….’unreviewable’ is not even a word! (Reuters) * Stark Divide: Americans More Confident in Career Scientists at U.S. Health Agencies Than Leaders (Annenberg: Public Policy Center, University of Pennsylvania) * Divisive F.D.A. Vaccine Regulator Is Resigning…..for the second time in 6 months (NY Times) * Characteristics and Outcomes of Patients With Hematologic Malignancies Hospitalized With Respiratory Viral Infections (OFID) * Dynamics of natural selection preceding human viral epidemics and pandemics (Cell) * Recent pandemic viruses, including SAR-CoV-2, spread directly to people without adaptation, researchers say (CIDRAP) * Wastewater for measles (WasterWater Scan) * US CDC deploys staff to curb South Carolina’s measles outbreak (Reuters) * Measles cases and outbreaks (CDC Rubeola) * Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * UtahMeasles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Effectiveness of RSV Vaccines against RSV-Associated Thromboembolic Events (CDC: Emerging Infectious Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Characteristics of Young Children Hospitalized With Acute Respiratory Failure From Infection With Respiratory Syncytial Virus, SARS-CoV-2, or Both, November 2023–March 2024 (OFID) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Where are the long COVID clinics? (ScienceNews) * Left without care: Many Long COVID clinics are closing down in the U.K. (The Sick Times) * Where have all the Long COVID clinics gone? (The Sick Times) * Reaching out to US house representative * Letters read on TWiV 1304 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews an association between shingles vaccination and slower biological aging, and how mucosal immunization in mice provides protection against disease caused by diverse viruses and bacteria.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * Shingles vaccination may slow biological aging (J Gerontol) * Getting virus classification and nomenclature right (J Virol) * Mucosal vaccination blocks diverse respiratory diseases (Science) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – I grew up unvaccinated. Now I’m an Immunologist Rich – Horizons from PBS News – The science behind exercise and why it’s good for our bodies; The London Busman Study (Cardiac Health) Alan –Waste Wars: The Wild Afterlife of Your Trash, by Alexander Clapp Vincent – America vs the World by Robert Kagan
Listener Pick Anne – Winners of the 2026 Underwater Photographer of the Year Award Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello talk about the health misconceptions that RFK Jr continues to perpetuate and how to combat them, first cases of highly pathogenic influenza in the California elephant seal population before Dr. Griffin deep dives into economic costs of not vaccinating against measles, the measles outbreak in South Carolinaand Utah, ICE detention centers, lack of accurate reporting may prevent the US from losing its status as a country that eliminated measles, immune amnesia from measles infection, influenza strain selection for the 2026-2027 vaccine, recent statistics for RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, when to use steroids for treating influenza, long COVID treatment center, where to go for answers to your long COVID questions, clinical trials for long COVID treatment including GLP-1 inhibitors and IVIG and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Kristen Panthagani, MD, PhD (Substack) * You can know things! (Substack) * Kmpanthagani: Kristen Panthagani, MD, PhD Instagram) * Kristen Panthagani, MD, PhD kmpanthagani (Threads) * Psychological inoculation improves resilience against misinformation on social media (Science) * 5 Logical fallacies in the era of RFK Jr. (Substack) * Tecovirimat for the Treatment of Mpox (NEJM) * California records avian flu in northern elephant seals (CIDRAP) * First Cases of Highly Pathogenic Avian Influenza in Northern Elephant Seals Confirmed in California (UC Davis) * Wastewater for measles (WasterWater Scan) * The health and economic repercussions of declining MMR coverage in the United States (medRxiv) * 2025 measles resurgence carries estimated $244 million price tag (CIDRAP) * US builds case to retain measles elimination status as infections mount (Reuters) * Expert meeting on US measles elimination status delayed to November (Reuters) * ‘Nearly Every’ Child With Measles Suffers This Hidden Threat (Medscape) * CDC acting director Bhattacharya urges use of measles vaccine (Reuters) * Measles cases and outbreaks (CDC Rubeola) * Measles Dashboard (South Carolina Department of Public Health) * Utah measles outbreak response (Utah Department of Health and Human Services) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Escobar: ICE sending sick migrants to El Paso hospitals for quarantine (BorderReport) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) * WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * RSV Detection and Antibiotic Prescribing Decisions for Pediatric Respiratory Tract Infections (JAMA Network) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * SARS-CoV-2Persistence and the Gut Microbiota: New Insights into Long COVID Pathogenesis (MDPI) * Neither Metformin nor Ursodeoxycholic Acid Effectively Treats Postacute Sequelae of COVID-19 (Annals of Internal Medicine) * Long COVID: RECOVER-TLC Clinical Trials (Foundation for the National Institute of Health) * Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome (American Heart Journal) * Dr. Ruth’s Newsletter: COVID, Flu & Health News, 3/1/26 (Substack) Reaching out to US house representative * Letters read on TWiV 1302 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews lymphocytic choriomeningitis virus seroprevalence among urban pregnant women and newborns in Philadelphia, and a functional translation initiation complex encoded in the genome of giant viruses that drives synthesis of viral structural proteins.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * LCMV seroprevalence among pregnant women (Emerg Inf Dis) * Giant viruses encode functional vIF4F (Cell) * Ribosomal proteins encoded in viral genomes (virology blog) * Letters read on TWiV 1301 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – “The Song of the Cell” by Siddhartha Mukherjee. Kathy – Fitbit for farts (WSJ and 1° article) Rich – The Password That Lets Caterpillars Hide in an Ant’s Lair Vincent – Astrophysics for People in a Hurry by Neil deGrasse Tyson
Listener Pick Larry – Get an early start! (primary article) Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss several states and the governor of Pennsylvania suing HHS over changes in the childhood vaccination schedule, the vaccine derived type 2 poliovirus outbreak in Pakistan and implications for the global withdrawal of the oral poliovirus vaccine, and the outbreak of Candida, then Dr. Griffin deep dives into recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, when to use steroids for treating influenza, long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * States vs RFK Jr and Bhattacharya: changes to the childhood vaccine schedule (Office of the Attorney General, California) * Surgeon General Nominee Sidesteps Questions on Vaccines at Senate Hearing (NY Times) * Unqualified failure in polio vaccine policy left thousands of kids paralyzed (Science) * Clinical and Epidemiological Investigation of Vaccine-Derived Poliovirus Type 2 Outbreak in Pakistan During 2019–2021 (CID) * Inactivated Polio Vaccine Must Be an Essential Part of Polio Eradication (CID) * Wastewater for Candida auris: Wastewater (WasterWater Scan) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Utah Measles Dashboard (Utah Department of Health and Human Services) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Respiratory Diseases (Yale School of Public Health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium (eClinical Medicine) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Use of corticosteroids in influenza-associated acute respiratory distress syndrome and severe pneumonia: a systemic review and meta-analysis(Scientific Reports) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1300 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains how vaccine-induced thrombotic thrombocytopenia develops from antibodies to adenovirus and somatic hypermutation, and castration by a viral protein tyrosine phosphatase that targets a host cell cycle checkpoint protein.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * US repeals environmental endangerment finding (Nature) * Environmental groups sue EPA (Guardian) * NIAID to drop pandemic preparedness and biodefense (Nature) * FDA backpedals on Moderna mRNA rejection (npr) * Mechanism of VITT (NEJM) * Parasitc castration by a wasp virus protein (PNAS) * Polydnaviruses (PloS Path) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – The effect of seeing scientists as intellectually humble on trust in scientists and their research Rich – The Great Bridge: The Epic Story of the Building of the Brooklyn Bridge by David McCullough Alan – Recipes from the American South, by Michael Twitty Vincent – Why Returning From Mars ls Impossible – Richard Feynman’s Warning Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss reversal of last week’s no review decision on a flu mRNA vaccine by Vinjay Prasad, appointment of Jay Bhattacharya as CDC director, no experience required, and already detectable reduction in hepatitis B virus vaccination rates, then Dr. Griffin then deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, the consequences of measles infection on immune amnesia (shout out to Immune 26), long COVID treatment center, where to go for answers to your long COVID questions, long COVID effect on fertility and type 2 diabetes and contacting your federal government representative to stop the assault on science and biomedical research.
Click arrow to play Download TWiV 1298 (26 MB .mp3, 43 min) Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Whiplash! F.D.A. Reverses Decision and Agrees to Review Moderna’s Flu Vaccine * (NY Times, Wall Street Journal, Access New wire) * N.I.H. Director Will Temporarily Run C.D.C. in Leadership Shake-Up * (NY Times) * Reduction in infant Hepatitis B Immunizations (Oregon State Health Department) * Why Adenovirus vectored vaccine failed: Adenoviral Inciting Antigen and Somatic Hypermutation in VITT (NEJM) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) * Measles Outbreak Hits Florida College (NY Times) * Utah’s measles outbreak reaches 300 cases (CIDRAP) * Measles Is Actively Spreading in SLCo (Salt Lake County Health Department) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Measles 2025 (NEJM) * Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens (Science; Immune 26) * Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles (Science) * Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands (Nature Communications) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * The risk of cardiac disease events after respiratory syncytial virus disease: a systematic literature review and meta-analysis (European Respiratory Review) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * COVID-19 Antiviral Prescription Receipt Among Outpatients Aged ≥65 Years (CDC: MMWR) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Assessing the impact of SARS-CoV-2 infection and vaccination on fertility and assisted reproductive techniques outcomes: an umbrella review (Vaccine) * Long-Term Risk of Incident Type 2 Diabetes Following SARS-CoV-2 Infection: A Population-Based Study in British Columbia, Canada (Diabetes Metabolism Research and Review) * Reaching out to US house representative * Letters read on TWiV 1298 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains the observation that filamentous virions act as non-infectious interfering particles to modulate papillomavirus infection, and transmission of monkeypox virus from fire-footed rope squirrels to sooty mangabeys.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Positions in Rosenfeld Lab (email) * FDA refuses to review Moderna flu mRNA vaccine (CIDRAP) * Oz measles vaccine call, too little too late? (dw.com) * Defective human papillomavirus interfering virus particles (J Virol) * Fire-footed rope squirrel potential MPXV reservoir (Nature) * Squirrels could be MPXV reservoir (Nature) * Letters read on TWiV 1297 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Silo TV series Kathy – Ancient RNA expression profiles from the extinct woolly mammoth and Ancient host-associated microbes obtained from mammoth remains Alan – Ubik, by Philip K. Dick Vincent –Starry Messenger by Neil deGrasse Tyson
Listener Pick Beth – Iceland crime fiction authors Yrsa Sigurdardottir and Ragnar Jonasson
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello are shocked by recent events, including Dr. Oz’s appeal for measles vaccination, Vinjay Prasad’s unilateral rejection of Moderna’s mRNA influenza vaccine application, and the increasing number of New World screw worm cases, then Dr. Griffin then deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, the number of measles deaths in Mexico, long COVID treatment center, where to go for answers to your long COVID questions, choroid plexus alterations in long COVID association with neuropathologies and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * How Dr. Oz’s appeal to get measles vaccine may differ from RFK Jr.’s messaging (ABC News) * FDA reverses course, refuses to review Moderna’s application for new mRNA flu vaccine (CIDRAP) * Hepatitis B Vaccination at Birth: Safety, Effectiveness, and Public Health Benefit (American Academy of Pediatrics: Pediatrics) * US Olympic Committee remains ‘dialed in’ to prevent spread of stomach illness at Winter Games (CNN) * Oz promotes measles vaccination (NY Times; USA Today; Fortune) * Screw worm in Mexico (Gobierno de Mexico) * Mexico reports more human New World screwworm infections (CIDRAP) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Measles outbreak poses risk of ‘irreversible’ brain damage, health officials warn (Fox News) * In Mexico, at least 28 have died from measles outbreak that started 2025 (Reuters) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * Influenza vaccination and the risk of myocardial infarction(BMC Publich Health) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Long-term impact of nirsevimab on prevention of respiratory syncytial virus infection using a real-world global database (Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Choroid plexus alterations in long COVID and their associations with Alzheimer’s disease risks (Alzheimer’s & Dementia) * Reaching out to US house representative * Letters read on TWiV 1296 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews a survey conducted in Cambodia's floating villages to explore measles vaccination perceptions and willingness to consider novel vaccination approaches, and how a prophage defends against an infecting phage.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2026 * Positions in Rosenfeld Lab (email) * Update on US measles outbreak (npr) * Tracking Poll on Trust in the CDC and Views of Federal Childhood Vaccine Schedule Changes (KFF) * Measles vaccination perceptions in Cambodia (J Virol) * Prophage defends against infecting phage (Cell Host Micro) * Letters read on TWiV 1295 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne - Libib book cataloging app Rich - The Mysterious Case of Rudolf Diesel: Genius, Power, and Deception on the Eve of World War I by Douglas Brunt Jolene - Ellie Jameson artwork and Redbubble Vincent - Recursion by Blake Crouch
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update during Ground hog week, Dr. Griffin and Vincent Racaniello are back to discuss the measles outbreak in South Carolina, American Academy of Pediatrics vaccine recommendations and shingles vaccine and the reduction of dementia, then deep dives into recent statistics RSV, influenza and SARS-CoV-2 infections, the Wastewater Scan dashboard, Johns Hopkins measles tracker, where to find PEMGARDA, how to access and pay for Paxlovid, estimated effectiveness of this year’s COVID-19 vaccine, long COVID treatment center, where to go for answers to your long COVID questions, long COVID in children, the potential benefits of metformin to reduce disease severity following SARS-CoV-2 infection in obese and overweight patients and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Grading the groundhogs (National Oceanic and Atmospheric Administration) * Sand Mountain Sam predicts an early spring (News19) * All About the AAP Recommended Immunization Schedule (healthychildren.org) * Recommended Childhood and Adolescent Immunization Schedule: United States, 2026: Policy Statement (American Academy of Pediatrics: Pediatrics) * Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments (LANCET: Neurology) * Detection of avian flu antibodies in Dutch dairy cow: ECDC risk assessment remains unchanged (European Centre for Disease Prevention and Control) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Big outbreak, bright lights…Measles Dashboard(South Carolina Department of Public Health) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Estimated Effectiveness of 2024-2025 COVID-19 Vaccination Against Severe COVID-19 (JAMA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study (LANCET: Infectious Diseases) * Long COVID is here to stay—even in children (LANCET: Infectious Diseases) * Early administration of neutralising monoclonal antibodies and post-acute sequelae of COVID-19 (International Journal of Infectious Diseases) * Preventing Long COVID With Metformin (CID) * Metformin may reduce risk of long COVID by 64% in overweight or obese adults * (CIDRAP) * Effect of Metformin on the Risk of Post-coronavirus Disease 2019 Condition Among Individuals With Overweight or Obese (CID) * Preventing Long COVID With Metformin (CID) * New review highlights growing evidence that diabetes drug metformin can prevent long COVID (CIDRAP) * Reaching out to US house representative * Letters read on TWiV 1294 * Dr. Griffin's COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews the finding in Sweden that immunization against cervical cancer with human papillomavirus vaccine also protects the non-immunized, and methyl salicylic acid as a key volatile molecule that attracts parasitoid wasps to rice and other crops to destroy destructive leafhoppers, and is down-regulated by virus infection to enable virus spread.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2026 * Positions in Rosenfeld Lab (email) * "Host adaptations to viral infections” International Meeting * William Foege dies (NY Times) * Peter Duesberg dies (NY Times) * US gov't lost over 10,000 PhDs under DJT (Science) * Herd effect of HPV vaccination (Lancet Pub Health) * Arboviruses manipulate rice's volatile emissions (Sci Adv) * Letters read on TWiV 1293 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Kathy - The Beak of the Finch, by Jonathan Weiner Rich - Washington: A Life by Ron Chernow Vincent - The Man from Beijing by Henning Mankell
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss with disgust the decline and fall of American public health and the rise of “only me” when highlighting completion of the US withdrawal from the WHO and possibility of making IPV and MMR optional vaccines, before Dr. Griffin then deep dives into recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, Europe losing its measles elimination status, first measles death in Mexico, almost 1000 measles cases in South Carolina, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, the effectiveness of this season’s influenza vaccine, where to go for answers to your long COVID questions and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * US completes withdrawal from World Health Organization (AP News) * Rejecting Decades of Science, Vaccine Panel Chair Says Polio and Other Shots Should Be Optional (NY Times) * A Frightening Interview (Beyond the Noise) * Unexplained Pauses in Centers for Disease Control and Prevention Surveillance: Erosion of the Public Evidence Base for Health Policy (Annals of Internal Medicine) * Wastewater for measles (WasterWater Scan) * UK among 6 European countries losing measles elimination status (Dougall MD: DG Alerts) * European Regional Verification Commission for Measles and Rubella Elimination (RVC) (WHO: Europe) * Measles Outbreak Associated with an Infectious Traveler — Colorado, May–June 2025 (CDC: MMWR) * South Carolina measles cases hit 789, surpassing Texas' 2025 outbreak total (Reuters) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * States across the country report first measles cases of year(CIDRAP) * First measles death confirmed in Mexico in 2026 (Mexico News) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * Influenza Vaccine Effectiveness Among Children With and Without Underlying Conditions(Pediatrics) * OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Effectiveness and Durability of the BNT162b2 KP.2 vaccine against COVID-19 Hospitalization and Emergency Department or Urgent Care Encounters in US Adults (OFID) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Association of Nirmatrelvir-ritonavir with intubation or mortality risks in severe COVID-19 patients (BMC Infectious Diseases) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1292 * Dr. Griffin's COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains emergence of a neurovirulent double recombinant from the ‘improved’ nOPV2 in Uganda, and efficiency of viral entry determined whether cells are latently or lytically infected with cytomegalovirus.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2026 * Positions in Rosenfeld Lab (email) * nOPV2 neurovirulent recombinant in Uganda (Nat Micro) * 2023 IMB report on polio eradication * Viral entry shapes HCMV latency establishment (Nat Comm) * Letters read on TWiV 1291 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Dark Matter by Blake Crouch Rich – Sequoiadendron giganteum; Sequoia & Kings Canyon National Park Alan – The Murderbot Diaries book series, by Martha Wells Vincent – Surely You’re Joking, Mr. Feynman!
Listener Picks Rocky – Cheetah mummies found in cave (Nature, National Geographic)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss screwworm, how the shingles vaccination slows biological aging (for all of you who want to reset ‘the clock’ and live forever…..you know who you are Musk, Bezos) and getting one dose of the HPV vaccine, then Dr. Griffin then deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how losing our elimination status is the cost of doing business (going for broke is never a good business model !) where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, the effectiveness of this season’s influenza vaccine, where to go for answers to your long COVID questions and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * New World Screwworm: Outbreak Moves into Northern Mexico……with an official tag “This is an official CDC Health Advisory” (CDC: Health Alert Network) * Association between shingles vaccination andslower biological aging: Evidence from a U.S. population-based cohort study (The Journals of Gerontology series A) * Noninferiority of One HPV Vaccine Dose to Two Doses (NEJM) * Herd effect of human papillomavirus vaccination on incidence of high-grade cervical lesions: (LANCET: Public Health) * Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service) * Detections of Highly Pathogenic Avian Influenza in Wild Birds (USDA: Animal and Plant Health Inspection Service) * Delaware, Georgia see major commercial avian flu outbreaks (CIDRAP) * Wastewater for measles (WasterWater Scan) * Notes from the Field: Wastewater Surveillance for Measles Virus During a Measles Outbreak — Colorado, August 2025 (CDC: MMWR) * Notes from the Field: Retrospective Analysis of Wild-Type Measles Virus in Wastewater During a Measles Outbreak — Oregon, March 24–September 22, 2024 (CDC: MMWR) * Measles cases and outbreaks (CDC Rubeola) * Measles vaccine recommendations from NYP (jpg) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Utah measles total rises to 216; CDC deputy director says losing elimination status‘cost of doing business’ (CIDRAP) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Assessing MMR vaccination coverage gaps in US children with digital participatory surveillance (Nature Health) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Effectiveness of influenza vaccination to prevent severe disease: a systematic review and meta-analysis of test-negative design studies (CMI: Clinical Microbiology and Infection) * Interim vaccine effectiveness against influenza virus among outpatients, France, October 2025 to January 2026 (Eurosurveillance) * Moderate protection from vaccination against influenza A(H3N2) subclade K in Beijing, China, September to December 2025 (Eurosurviellance) * Current flu vaccine provides moderate protection against severe disease, interim analyses suggest (CIDRAP) * OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virusnfection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID Reaching out to US house representative * Letters read on TWiV 1290 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains how the dengue virus protein NS1 alters Aedes aegypti midgut permeability and favors virus dissemination, and achieving a complete hepatitis B virus cure in chronic hepatitis B virus-infected humanized mice by using a capsid assembly modulator.
Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2026 * Positions in Rosenfeld Lab (email) * Dengue virus NS1 alters mosquito midgut permeability (mBio) * HBV cure with a capsid assembly modulator (Cell Host Microbe) * Letters read on TWiV 1289 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – How hibernating bears maintain muscle mass Alan – The flood of Chinese grad students in the 2000s was a boon to US students. Vincent – Feynman Lectures on Physics
Listener Picks David – Stewart Cheifet, Host of TV’s ‘Computer Chronicles,’ Dies at 87 Charles – Last Year, and the Year to Come
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello are bewildered and dismayed by RFK Jr’s announced changes in the routine childhood immunization schedule, though not unpredicted, and highlight the science and evidence which eviscerate these changes, then deep dives into recent statistics on the measles epidemic- in particular in South Carolina, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, estimated societal burden of COVID-19 illness, deaths and hospitalizations, benefit of maternal COVID-19 vaccination, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, neurodevelopmental consequences of in-utero SARS-CoV-2 infection and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * 7 great Danish cheeses you should know (Cheese Professor) * Norovirus in on the rise! (WasterWater Scan) * Maternal Vaccine Receipt and Infant Hospital and Emergency Visits for Influenza and Pertussis (JAMA Open) * TUESDAY MEASLES UPDATE: DPH Reports 124 New Measles Cases in Upstate, New Public Exposures, and Upcoming Vaccination Opportunities (South Carolina: Department of Public Health-they have one?) * Measles cases soar in South Carolina, top 400 (CIDRAP) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * North Dakota confirms pediatric flu deaths as some states note surge in flu activity (CIDRAP) * OPTION 2: XOFLUZA $50 Cash Pay Option (Xofluza) * The Best Flu Drug Americans Aren’t Taking (The Atlantic) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * Impact of universal nirsevimab prophylaxis in infants on hospital and primary care outcomes across two respiratory syncytial virus seasons in Galicia, Spain (NIRSE-GAL): a population-based prospective observational study (Lancet: Infectious Diseases) * Interim Safety of RSVpreF Vaccination During Pregnancy (JAMA) * Pfizer’s RSV vaccine safe to use during pregnancy, study suggests (CIDRAP) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Evaluating the Effectiveness of 2024–2025 Seasonal mRNA-1273 Vaccination Against COVID-19-Related Hospitalizations and Medically Attended COVID-19 Among Adults Aged ≥ 18 years in the United States: An Observational Matched Cohort Study (Infectious Diseases and Therapy) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Use of corticosteroids in influenza-associated acute respiratory distress syndrome and severe pneumonia: a systemic review and meta-analysis(Scientific Reports) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Incidence and Severity of Postacute Sequelae of SARS-CoV-2 Infection in the Omicron Era: A Prospective Cohort Study (JID) * Reaching out to US house representative * Letters read on TWiV 1288 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explain the tracing of 2500 years of human betaherpesvirus 6A and 6B diversity through ancient human DNA, the effect of shingles vaccination at different stages of the dementia disease course.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2026 * Positions in Rosenfeld Lab (email) * Ancient human herpesvirus 6 (Sci Adv) * First through sixth diseases (Merck Manual) * Effect of shingle vaccination on different stages of dementia (Cell) * Letters read on TWiV 1287 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne –TWiM Annotations and Resources Book for Teaching Alan – Starter Villain, by John Scalzi Rich – Redshirts: A Novel with Three Codas, by John Scalzi Vincent – Mina’s Matchbox by Yoko Ogawa
Listener Picks Rona – Maggie and Millie and Molly and May by Natalie Merchant Owen – How to get the vaccines you need now
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello are bewildered and dismayed by RFK Jr’s announced changes in the routine childhood immunization schedule, though not unpredicted, and highlight the science and evidence which eviscerate these changes, then deep dives into recent statistics on the measles epidemic- in particular in South Carolina, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, estimated societal burden of COVID-19 illness, deaths and hospitalizations, benefit of maternal COVID-19 vaccination, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, neurodevelopmental consequences of in-utero SARS-CoV-2 infection and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Childhood Immunization Schedule by Recommendation Group (US Health and Human Service) * Recommended Child and Adolescent Immunization Schedule for Ages 18 Years or Younger (American Academy of Pediatrics) * Kennedy Scales Back the Number of Vaccines Recommended for Children (NY Times) * There RFK Jr. Goes Again . . .(Wall Street Journal) * Hepatitis B Vaccination is an Essential Safety Net for Newborns (Johns Hopkins Bloomberg School of Public Health) * Effectiveness and Impact of Maternal RSV Immunization and Nirsevimab on Medically Attended RSV in US Children (JAMA Pediatrics) * Rotavirus (College of Physicians of Philadelphia) * Hepatitis A in the Era of Vaccination (Epidemiologic Reviews) * Meningococcal Vaccination in the United States: Past, Present, And Future (Ped Drugs) * Meningococcal Vaccination: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020 (CDC: MMWR) * N.Y. DOH says childhood vaccine recommendations remain unchanged despite CDC’s update (Spectrum 1 News) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * South Carolina measles cases rise by 26 to 211, state health department says (Reuters) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * Estimated Burden of COVID-19 Illnesses, Medical Visits, Hospitalizations, and Deaths in the US From October 2022 to September 2024 (JAMA Internal Medicine) * The Role of Vaccination in Maternal and Perinatal Outcomes Associated With COVID-19 in Pregnancy (JAMA) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * The COVID generation: the neurodevelopmental consequences of in-utero COVID-19 exposure (Brain, behavior and Immunity) * Reaching out to US house representative * Letters read on TWiV 1286 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews compelling virology themes for 2024, as heard in our 98 episodes, including 22 guests.
Hosts: Vincent Racaniello and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2026 * Dismantling of science and public health in the US including TWiV 1199, TWiV 1191, TWiV 1197, TWiV 1203, TWiV 1205 , TWiV 1209, TWiV 1211, TWiV 1215, TWiV 1217, TWiV 1219, TWiV 1221, TWiV 1223, TWiV 1225, TWiV 1227, TWiV 1231, TWiV 1233, TWiV 1241, TWiV 1243, TWiV 1245, TWiV 1285. * Herpesviruses and dementia TWiV 1187, TWiV 1207, TWiV 1249, TWiV 1263, TWIV 1233 * Hepatitis B, C TWiV 1213, TWIV 1237, Chari Cohen, Stephan Urban, Thomas Tu, TWiV 1279 * POTW themes/highlights * Dickson Despommier passes TWIV 1195, TWiP 254, YouTube excerpt, DDD Photography, ‘Despommier’s Parasitic Diseases’ * H5N1 in dairy cattle TWiV 1193, TWiV 1257, TWiV 1259 (goats), TWiV 1211 * EBV and Lupus TWiV 1273 * Vaccines TWiV 1209, TWiV 1265, TWiV 1267 * Some classic papers TWIV 1241, TWiV 1273, TWiV 1275, TWiV 1279, TWiV 1269 * Respiratory infections awaken dormant breast cancer cells TWiV 1243 * Phages TWiV 1261, TWiV 1181 * Letters read on TWiV 1285 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Kathy – APOD for 1/1/2026; American Kestrals Put the Cherry on Top Primary article (open access) Vincent – Science in Your Own Back Yard by Elizabeth Cooper
Listener Picks Bill – They did the Monster Slash and Elle Cordova Rona – The married scientists torn apart by a COVID bioweapon theory
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
Recording after the ball drops, Dr. Griffin and Vincent Racaniello wish everyone a Happy New Year, discuss an evidence-based approach to teaching and practice medicine and reminisce on the history of vaccine development and use before their discussion about the whooping cough outbreak of 2025 in the US and falling levels of tetanus vaccination, then Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how NY state reported the greatest number of influenza confirmed infections ever in one week during the week ending Dec 20, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Evidence-Based Medicine: A New Approach to Teaching the Practice of Medicine (JAMA) * The US has seen nearly 28,000 whooping cough cases this year. Here’s what you need to know (CNN) * Vaccine History: Developments by Year (CHOP, Children’s hospital of Philadelphia: Vaccine History) * Reported Incidence of notable diseases in United States: 1952 Morbidity and Mortality Weekly Report, Vol. 1, No. 54, October 26, 1953 (CDC: Stacks) * As tetanus vaccination rates decline, doctors worry about rising case numbers (nbc News) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * New York State Department of Health Confirms Most Flu Cases Ever Recorded in One Week: New York State Reports 71,123 Flu Cases This Week (NY State Department of Health) * Weekly surveillance report: cliff notes (CDC FluView) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Nirsevimab vs RSVpreF Vaccine for Respiratory Syncytial Virus–Related Hospitalization in Newborns (JAMA) * RSV Immunization Frequently Asked Questions(American Academy of Pediatrics) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1284 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains studies which reveal that Inhibition of CXCL10 and IFN-γ mitgates myocarditis associated with SARS-CoV-2 mRNA vaccination, and identification of a bacteriophage T7 protein that antagonizes the DNA restriction system of the host by mimicking B form DNA.
Hosts: Vincent Racaniello and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2026 * Understanding mRNA vaccine-associated myocarditis (Sci Transl Med) * T7 protein overcomes DNA restriction of host (J Mol Biol) * Structure of T7 protein that mimics DNA (Mol Cell) * Letters read on TWiV 1283 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Jolene – Book series Dinosaur Therapy, Dinosaur Philosophy, & Dinosaur Friendship Vincent – One Plus One Equals One: Symbiosis and the evolution of complex life by John Archibald
Listener Picks Terry – Arcadia by Tom Stoppard Greg – Charctic Interactive Sea Ice Graph | National Snow and Ice Data Center
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
Calling out “Happy Christmas to all and to all a good-night, Dr. Griffin and Vincent Racaniello discuss high path influenza in dairy herds in Wisconsin and Marburg virus in Ethiopia before Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the slightly higher association of COVID-19 infection with death than following influenza infection, benefit of passive infant immunization with niresevimab, association of COVID-19 vaccine immunogenicity protection against severe disease in vulnerable populations, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, effect of remdesivir and nirmatrelvir/ritonavir on COVID-19 associated mortality, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * USDA Confirms Highly Pathogenic Avian Influenza in a Dairy Herd in Wisconsin * (USDA Animal and Plant Health Inspection Service) * Update: Genetic Sequencing Results for Wisconsin Dairy Herd Detection of Highly Pathogenic Avian Influenza(USDA Animal and Plant Health Inspection Service) * Marburg Outbreak in Ethiopia: Current Situation (CDC: Marburg Virus Disease) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * In call with clinicians, CDC recommends flu vaccines widely(CIDRAP) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * Increased 30-day Mortality Risk in Coronavirus Disease 2019 Compared to Seasonal Influenza (International Journal of Infectious Diseases) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Nirsevimab vs RSVpreF Vaccine for Respiratory Syncytial Virus–Related Hospitalization in Newborns (JAMA) * RSV Immunization Frequently Asked Questions(American Academy of Pediatrics) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Association between COVID-19 vaccine immunogenicity and protection against infection and severe disease in clinically vulnerable patient populations: a systematic review and meta-analysis of observational studies (Clinical Microbiology and Infection) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * The effect of remdesivir and nirmatrelvir/ritonavir on mortality in patients hospitalized with COVID-19 during the Omicron era: an emulated target trial (Clinical Microbiology and Infection) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long-COVID research just got a big funding boost: will it find new treatments? (Nature) Reaching out to US house representative * Letters read on TWiV 1282 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent travels to Tegernsee, Germany for the Sixth Ringberg Symposium on Giant Viruses, where he talks with John Archibald, Susana Coelho, and Tom Delmont about their work on – you guessed it – giant viruses.
Host: Vincent Racaniello Guests: John Archibald, Susana Coelho, and Tom Delmont
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Transposable elements shaping Ectocarpus genome (Genome Biol) * Mirusviruses link herpesviruses to giant viruses (Nature) * Mirusviruses predicted to reproduce in nuclei (Nat Micro) * Persistent mirusvirus infection in the marine protist Aurantiochytrium (Nat Com) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello protest Vinjay Prasad, head of CBER FDA Nov memo stating administration of the COVID-19 vaccine resulted in 10 children’s deaths, but are cautiously delighted by the December memo from those in CBER who dispute this data-less claim, how in 31 states pertussis vaccination rates have declined before Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, of clinical outcomes of oseltamivir versus baloxavir for treating influenza infection, number deaths associated with COVID-19 hospitalizations and disease associated economic burden, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, how the German government is committed to research into long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Industry laments Prasad vaccine memo (Politico) * Scoop: FDA vaccine chief’s memo cited 10 pediatric Covid-19 vaccine deaths—but the agency’s own analysis found 0–7 (Inside Medicine) * Whooping cough cases soar as vaccination rates drop (NBC News) * Marburg Outbreak in Ethiopia: Current Situation (CDC: Marburg Virus Disease) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles(CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Hundreds quarantined as South Carolina measles outbreak accelerates (Washington Post) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * In call with clinicians, CDC recommends flu vaccines widely (CIDRAP) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * Comparison of clinical outcomes of oseltamivir versus baloxavir in outpatients with influenza: a retrospective cohort analysis (International Journal of Infectious Diseases) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Effectiveness of 2024–2025 COVID-19 Vaccines in Children in the United States — VISION, August 29, 2024–September 2, 2025 (CDC:MMWR) * Mortality following recovery from COVID-19 hospitalization: A long-term cohort study (International Journal of Infectious Diseases) * COVID hospitalization tied to 69% higher risk of death for up to 2 years (CIDRAP) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Comparison of work productivity losses in the United States among employees with COVID-19 at high-risk of severe disease who were untreated or treated with nirmatrelvir/ritonavir (Journal of Medical Economics) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long-COVID research just got a big funding boost: will it find new treatments?(Nature) * Reaching out to US house representative * Letters read on TWiV 1280 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews considerations and perspectives on phage therapy, and the Nobel Prize-winning discovery of hepatitis b virus.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Immune 100 live at the Incubator * ASV 2026 * WHO global expert committee: no link between vaccines and autism (News-Medical) * Considerations on phage therapy (Nat Comm) * What is TATFAR? (CDC) * History of phage therapy (one, two) JAMA * Viruses that (can) make you well (TWiV 1153) * The InVinceable TWiV (TWiV 145) * Blumberg Nobel Lecture 1976 * Particles associated with Australia antigen in patients (Nature) * HBV vaccination remains vital for saving lives (Hep B Foundation) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Rich – Scientist’s cat, again, helps discover new virus Alan – Wormtalk video on politicization of screwworm spread Jolene –Arrowsmith by Sinclair Lewis Vincent – Scoop: FDA vaccine chief’s memo cited 10 pediatric Covid-19 vaccine deaths—but the agency’s own analysis found 0–7
Listener Picks David – Astronomy Picture of the Day Eric – Jesse Welles (United Health)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the rise in norovirus infections, contamination of infant formula and botulism outbreak, confusion and response to the CDC’s ACIP decision to reverse the recommendation for a birth dose of the hepatis B virus vaccine and how states in the Northwest and Northeast are responding as well as some insurance companies, then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, South Carolina’s imposed quarantine of individuals due to their accelerated measles outbreak, neurotropism of H1N1, benefits of the RSV and COVID vaccines, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Norovirus season! (Wastewater Scan) * Outbreak Investigation of Infant Botulism: Infant Formula (November 2025) (FDA: Foodborne illnesses) * Botulism outbreak sickens more than 50 babies and expands to all ByHeart products (AP News) * CDC advisers drop decades-old universal hepatitis B birth dose recommendation, suggest blood testing after 1 dose (CIDRAP) * Health and Economic Benefits of Routine Childhood Immunizations in the Era of the Vaccines for Children Program — United States, 1994–2023 (CDC: MMWR) * Universal Hepatitis B vaccination at birth: safety, effectiveness and public health impact (CIDRAP) * Recommended Child and Adolescent Immunization Schedule for Ages 18 years or younger (American Academy of Pediatrics) * West Coast health experts reject RFK Jr. panel, say hepatitis B vaccines at birth should continue (The Oregonian) * Statement from the Northeast Public Health Collaborative In Response to ACIP’s Hepatitis B Vote (NJ.Gov Health) * Governors Denounce ACIP Recommendation on Hepatitis B Vaccination, Reaffirm Commitment to Strong, Evidence-Based Childhood Vaccination Programs (Governors Public Health Alliance) * Blue Cross and Blue Shield Companies Statement on Vaccines (Blue Cross Blue Shield) * AHIPStatement on Vaccine Coverage (AHIP) * Pediatricians reject CDC advisers’ guidance, plan to continue vaccinating all newborns against hepatitis B (CIDRAP) * Survey: Social media on par with CDC as trusted vaccine source (Healio) * FDA to investigate whether adult deaths linked to COVID vaccine (Washington Post) * Exclusive: US FDA launches fresh safety scrutiny of approved RSV therapies for infants (Reuters) * Marburg Outbreak in Ethiopia: Current Situation (CDC: Marburg Virus Disease) * Contemporary highly pathogenic avian influenza (H5N1) viruses retain neurotropism in human cerebral organoids (OFID) * Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service) * Indiana, cases of New World screwworm in Mexico, rising US flu activity * (CIDRAP) * Mexico reports 92 cases of myiasis in humans caused by screwworm (Expreso.press) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Hundreds quarantined as South Carolina measles outbreak accelerates (Washington Post) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * USrespiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * ACIP Recommendations Summary (CDC: Influenza) * Types of Influenza Viruses (CDC: Influenza (flu)) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * USrespiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Intensive Care Unit Stay and Mechanical Ventilation Among Adults with Respiratory Syncytial Virus-Related Hospitalization by Age and Comorbidity Status (Infectious Diseases and Therapy) * Cardiovascular Events 1 Year After Respiratory Syncytial Virus Infection in Adults (JAMA: Open Network) * Long-Term Illness in Adults Hospitalized for Respiratory Syncytial Virus Disease, United States, February 2022–September 2023 (CDC: Emerging Infectious Diseases) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Effectiveness of the maternal RSVpreF vaccine against severe disease in infants in Scotland, UK: a national, population-based case–control study and cohort analysis (LANCET: Infectious Diseases) * Effectiveness of Nirsevimab in Preventing Respiratory Syncytial Virus-related Burden: A Test-negative Case-control Study in Infants With Bronchiolitis in Lombardy Region, Italy (The Pediatric Infectious Disease Journal) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Maternal and Neonatal Outcomes After Respiratory Syncytial Virus Prefusion F Protein Vaccination During Pregnancy (Obstetrics & Gynecology) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * COVID-19 mRNA Vaccination and 4-Year All-Cause Mortality Among Adults Aged 18 to 59 Years in France (JAMA: Open Network) * Two-year prognosis of mRNA vaccine-related myocarditis compared with historical conventional myocarditis: a population-based cohort study (CMI: Clinical Microbiology and Infection) * Where to get pemgarda (Pemgarda) * EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * UnderstandingCoverageOptions (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulationguidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID Reaching out to US house representative * Letters read on TWiV 1278 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Infectious diseases physician Jake Scott returns to TWiV to discuss the dangerous anti-vaccine policies being established in the US and what RFK Jr. and his associates get wrong.
Hosts: Vincent Racaniello, Rich Condit, and Angela Mingarelli Guest: Jake Scott
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Vaccine RCT spreadsheet (CIDRAP) * What RFK Jr gets wrong about vaccines (Conversation) * RFK Jr’s case against mRNA vaccines collapses (STAT) * Too many kids’ vaccines? Think again (STAT) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Angela Palmer, science meets art (one, two) Rich – TWiV Special: A Shot of Hep B with Thomas Tu; TWiV Special: A shot of HepB with Chari Cohen Vincent – TSA is checking senior’s phones for these 5 apps
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss the positive side effect of the shingles vaccine on dementia outcomes and how one dose of the HPV vaccine is non-inferior to two doses, but are dismayed about the FDA’s secrecy around the inflammatory statement that the COVID-19 vaccine is linked to the death of 10 children. Dr. Griffin then deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, effectiveness of maternal administration of the RVS vaccine or the COVID vaccine for neonates, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, how celiac plexus blocks improves gastrointestinal long COVID symptoms, brain alterations and neurodegenerative processes in long COVID cognitive impairment and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * The effect of shingles vaccination at different stages of the dementia disease course * (Cell) * FDA links 10 children’s deaths to COVID-19 vaccines. Doctors want proof (ABC News) * Subject: Deaths in children due to COVID-19 vaccines and CBER’s path forward Dear Team CBER,(Washington Post) * Noninferiority of One HPV Vaccine Dose to Two Doses(NEJM) * Marburg Outbreak in Ethiopia: Current Situation (CDC: Marburg Virus Disease) * Washington state resident believed to be the first to die from a rare strain of bird flu (AP News) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * ACIP Recommendations Summary (CDC: Influenza) * Types of Influenza Viruses (CDC: Influenza (flu)) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Maternal and Neonatal Outcomes After Respiratory Syncytial Virus Prefusion F Protein Vaccination During Pregnancy (Obstetrics & Gynecology) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Effectiveness of COVID-19 vaccines against post-COVID-19 condition/long COVID: systematic review and meta-analysis (CMI: Clinical Microbiology and Infection) * SARS-CoV-2Infection Versus Vaccination During Pregnancy: Implications for Placental Antibody Transfer (The Pediatric Infectious Disease Journal) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Case Report: Celiac plexus block improves gastrointestinal Long COVID symptoms (Frontiers Neuroscience) * Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19 (Nature Communications) * Reaching out to US house representative * Letters read on TWiV 1276 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Immune 100 live at the Incubator * Spliced segments of adenovirus mRNA (PNAS) * An amazing sequence in adenovirus mRNA (Cell) * Nobel Prize for mRNA splicing (Nobel) * A predominant undecanucleotide in adenovirus late mRNAs (Cell) * Splicing RNA with Phillip A. Sharp (ASM) * Protein production in the gut by engineered phage (Nat Biotech) * Engineered phage T4 (Curr Op Virol) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Can You Identify These Lines from Classic SciFi Novels? Kathy –Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello wish everyone a Happy Thanksgiving and then decry appointment of the Louisiana State surgeon general as deputy chief of the CDC, the 3 children’s deaths during this fall’s pertussis outbreak, the Marburg virus outbreak in Ethiopia, results of the phase 1 safety trial for the novel poliovirus vaccines nOPV1 and nOPV3, and the first human death from H5N5 influenza virus infection in the US this fall, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, effectiveness of the cell or egg based flu or the mRNA vaccines, immunogenicity and efficacy of updated COVID-19 vaccines, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, immune and cognitive dysfunction during long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Anti-science Movement: Deputy director of CDC (X:Louisiana Office of the Surgeon General) * CDC’s new deputy director is vocal critic of vaccines, advocated for ivermectin (CIDRAP) * Whooping cough cases on the rise in Texas (FOX4: KDFW) * Third infant in Kentucky dies of whooping cough as national cases stay high for second year in a row (CIDRAP) * More than 25,000 whooping cough cases reported this year as Kentucky records 3rd infant death (ABC News) * Vaccination Coverage and Exemptions among Kindergartners (CDC: SchoolVaxView) * Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV‐related disease and harms from vaccination (Cochrane Library) * Marburg Outbreak in Ethiopia: Current Situation (CDC: Marburg Virus Disease) * Safety and immunogenicity of novel live attenuated type 1 and type 3 oral poliomyelitis vaccines in healthy adults in the USA: a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial (LANCET: Infectious Diseases) * Washington state resident believed to be the first to die from a rare strain of bird flu (AP News) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Superior Effectiveness and Estimated Public Health Impact of Cell- Versus Egg-Based Influenza Vaccines in Children and Adults During the US 2023–2024 Season (Infectious Diseases and Therapy) * Efficacy, Immunogenicity, and Safety of Modified mRNA Influenza Vaccine(NEJM) * ACIP Recommendations Summary (CDC: Influenza) * Types of Influenza Viruses (CDC: Influenza (flu)) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Estimating Risk of Guillain-Barré Syndrome in US Medicare-Enrolled Older Adults Following Medically Attended Respiratory Syncytial Virus Disease (CID) * FDA Requires Guillain-Barré Syndrome (GBS) Warning in the Prescribing Information for RSV Vaccines Abrysvo and Arexvy: FDA Safety Communication (FDA) * Brag Sets Off a Chain Reaction — Dr. Oz Takes the Bait, But Fumbles the Math, and Starts Unraveling Mid-Interview (Atlanta BlackStar) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Effectiveness of the BNT162b2 and mRNA-1273 JN.1-adapted vaccines against COVID-19-associated hospitalisation and death: a Danish, nationwide, register-based, cohort study (LANCET: Infectious Diseases) * Immunogenicity of JN.1- and KP.2-Encoding mRNA COVID-19 Vaccines Against JN.1 Subvariants in Adult Participants (OFID) * SARS-CoV-2 vaccination and myositis in Norway and Sweden (Rheumatology) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential (OFID) * Evaluation of Interventions for Cognitive Symptoms in Long COVID (JAMA Neurology) * Reaching out to US house representative * Letters read on TWiV 1274 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains the 1953 paper by Watson & Crick proposing a structure for DNA, and the role of Epstein-Barr virus in triggering the autoimmune disease systemic lupus erythematosus.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Immune 100 live at the Incubator * CDC revives debunked ‘link’ between childhood vaccines and autism (npr) * A structure for deoxyribose nucleic acid (Nature pdf) * Three Papers, Three Lessons (Am J Resp Crit Care Med) * Discovery of Double Helix (Crick Papers) * Jim Watson was blinded by DNA (NY Times) * What Rosalind Franklin contributed (Nature) * EBV reprograms autoreactive B-cells in lupus (Sci Transl Med) * EBV and the making of lupus (Sci Transl Med) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Virus snowflakes Kathy – When “Physic(k)s Lost Its ‘k’ and other Language Quarks Vincent – The Peripheral by William Gibson
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello are dismayed by the changes on CDC vaccine website positively stating the link between autism and vaccination, the finding of wild type poliovirus 1 in Germany, Marburg virus in Ethiopia, decimation of the elephant breeding colony by H5N1 and the first human case of H5N5 influenza virus infection before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, antibody escape by seasonal flu viruses, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, if resistance exercise aids in recovery from long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Autism and Vaccines (CDC: Vaccine Safety) * A new road to eradication- WPV 1 in Germany from Afghanistan (Reuters) * Ethiopia confirms first outbreak of Marburg virus disease (WHO: Ethiopia) * Highly Pathogenic Avian Influenza Viruses (HPAIV) Associated with Major Southern Elephant Seal Decline at South Georgia (Communications Biology) * Avian flu has decimated world’s largest breeding colony of southern elephant seals (CIDRAP) * Washington resident is infected with a different type of bird flu (AP News) * Pelagic Seabirds (OceanAminals) * That sounds far away: Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals (Cell Reports) * Regional voices, different choices: Parents’ and caregivers’ HPV vaccine attitudes in the northeast and Southeast United States (Vaccine) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * ACIP Recommendations Summary (CDC: Influenza) * Emergence of seasonal influenza A(H3N2) variants with immune escape potential warrants enhanced molecular and epidemiological surveillance for the 2025–2026 season (University of Toronto Press) * Types of Influenza Viruses (CDC: Influenza (flu)) * With an absent CDC and mismatched ‘subclade K’ flu strain, experts face upcoming season with uncertainty (CIDRAP) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Long-term impact of nirsevimab on prevention of respiratory syncytial virus infection using a real-word global database (Journal of Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Estimating Risk of Guillain-Barré Syndrome in US Medicare-Enrolled Older Adults Following Medically Attended Respiratory Syncytial Virus Disease (CID) * FDA Requires Guillain-Barré Syndrome (GBS) Warning in the Prescribing Information for RSV Vaccines Abrysvo and Arexvy: FDA Safety Communication (FDA) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * COVID-19 vaccination is associated with reduced complications in pediatric patients with atopic dermatitis (Annals of Allergy, Asthma and Immunology) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * Risk mitigation of shared room ventilation and filtration on SARS-CoV-2 transmission: a multicenter test-negative study (Infection Control and Hospital Epidemiology) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Resistance Exercise Therapy After COVID-19 Infection(JAMA Open Network) * Reaching out to US house representative * Letters read on TWiV 1272 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent visits Virginia Tech for the CeZAP Symposium and speaks with XJ Meng and Kylene Kehn-Hall about their research on hepatitis E virus and Rift Valley fever virus.
Host: Vincent Racaniello
Guests: XJ Meng and Kylene Kehn-Hall
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Links for this episode * Support science education at MicrobeTV * Immune 100 live at the Incubator * Hepatitis E virus (Curr Op Micro) * Rift Valley fever virus NSs and autophagy (PLoS Path) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello record from the ASTMH meeting in Toronto and discuss continuing avian flu outbreaks, the continued global measles outbreak, the effectiveness of high and low doses of the influenza vaccine before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, children hospitalizations following COVID-19 and influenza vaccination, where to find PEMGARDA, how to access and pay for Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Five new avian flu outbreaks confirmed in ducks, turkeys in 3 US states (CIDRAP) * Confirmation of highly pathogenic Avian Influenza in Commercial and Backyard flocks (USDA: Animal and Plant Health Inspection Service) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * ACIP Recommendations Summary (CDC: Influenza) * Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD) (LANCET) * Relative effectiveness of the high-dose versus standard-dose influenza vaccines for the prevention of laboratory-confirmed influenza among Italian older adults during three recent seasons (International Journal of Infectious Diseases) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Long-term impact of nirsevimab on prevention of respiratory syncytial virus infection using a real-word global database (Journal of Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * COVID-19 and influenza deaths in Australian children 2018-2023: a national case analysis (Journal of Pediatric Infectious Diseases Society) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID Reaching out to US house representative * Letters read on TWiV 1270 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews the passing of James D. Watson, the research that showed human papillomaviruses to be present in genital and laryngeal papillomas and in some cervical cancers, and influenza virus infection, shedding and symptoms in a human challenge study.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Immune 100 live at the Incubator * James D. Watson dies (NY Times) * Russian translation of TWiV 1024 (Medium) * Canada’s new budget aims to lure US researchers (Science) * Bird flu surging and spreading while US agencies are asleep (npr) * US slashed WHO budget, now flu surveillance is suffering globally (npr) * HPV sequences in papillomas and cervical cancers (PNAS) * zur Hausen Nobel Prize 2008 (Nobel) * Vincent interviews zur Hausen (YouTube) * Influenza virus infection, shedding, and disease in humans (J Virol) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne –Pandemic board game Rich – Whiskey Fungus Fed by Jack Daniel’s Encrusts a Tennessee Town Alan – Rats can snatch bats out of the air and eat them Vincent – 7 basic science discoveries that changed the world
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses the link between in utero SARS-CoV-2 infection and poor neurodevelopment outcomes, the use of an mRNA vaccine as an anti-cancer therapy, why one should receive the HPV vaccine, asymptomatic H5N1 isolations in humans, and H5N1 on turkey farms, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how two vaccinated physicians became infected with measles, effective of COVID-19 vaccine for children, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, how a specific antibody type may associate with recovery from long COVID, if use of a probiotic is helpful to treat mild COVID-19, if vaccination helps prevent long in adolescents and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Neurodevelopmental Outcomes of 3-Year-Old Children Exposed to Maternal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Utero (Obstetrics & Gynecology) * SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade (Nature) * TWiV 1267: A cancer vaccine and an mpox treatment (microbeTV: TWiV1267) * Cancers Caused by HPV (CDC: Human papillomavirus (HPV)) * Circulating tumor human papillomavirus DNA whole genome sequencing enables human papillomavirus-associated oropharynx cancer early detection (Journal of National Cancer Institute) * Impact of Vaccinating Adult Women Who Are HPV-Positive or with Confirmed Cervical SIL with the 9-Valent Vaccine (Viruses) * ACIP Shared Clinical Decision-Making Recommendations (CDC: Advisory Committee on Immunization Practices (ACIP)) * HPV Vaccination Recommendation (CDC: Vaccines & Immunizations) * Asymptomatic Human Infections With Avian Influenza A(H5N1) Virus Confirmed by Molecular and Serologic Testing (JAMA: OPEN Network) * Review: Human H5N1 avian flu cases can be asymptomatic, and the virus likely spreads among people (CIDRAP) * Avian flu strikes turkey farms in Dakotas, large egg facility in California (CIDRAP) * Another Doctor at Ichilov Contracts Measles After Treating Unvaccinated Child (gov.il) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * ACIP Recommendations Summary (CDC: Influenza) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England (LANCET: Child & Adolescent Health) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Real-World Effectiveness of Nirmatrelvir-Ritonavir in Preventing Coronavirus Disease 2019–Associated Hospitalization (CID) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * SARS-CoV-2 spike-specific IgG4 class switching associates with clinical recovery in Long COVID (Journal of Infection) * Efficacy of Lactococcus lactis Strain Plasma in Patients with Mild COVID-19 (Infectious Diseases and Therapy) * Preventive effect of vaccination on long COVID in adolescents with SARS-CoV-2 infection (Vaccine) * Reaching out to US house representative * Letters read on TWiV 1268 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV discusses the impact of vaccinating with Gardasil-9 adult women who are human papillomavirus positive or with confirmed squamous intraepithelial lesions, and human monoclonal antibodies that target the monkeypox virus A35 protein which protect against lethal disease.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Immune 100 live at the Incubator * Long tailed macaques are now officially endangered (Science) * Iceland now has mosquitoes (npr) * Impact of Gardasil-9 on adult women who are HPV+ or SIL+ (Viruses) * Human mAbs that protect against mpox disease (Cell) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Civet coffee: The real chemistry behind this bizarre luxury drink Kathy –Astronomy photographer of the year awards Rich – Katherine Swan Ginsburg Humanism in Medicine Program Alan – Parasitic worms can use static electricity to latch onto flies midair Vincent – How to get the best night’s sleep: what the science says
Listener Pick Bradon – Elevated Access
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello ponder the nomination of Casey Means for Surgeon General by President Trump, how mRNA vaccines may enhance effectiveness of check point inhibitor cancer therapies, if viral infection associates with cardiac disease, H5N1 isolation from backyard birds and turkey farms, and the effectiveness of the COVID-19, RSV and influenza vaccines before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, if revaccination with the mRNA RSV vaccine is effective, how effective today’s COVID-19 vaccine is for protection against severe disease following infection with current viral variants, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * The Challenge of Malignancies in HIV-1, Beyond Immune Activation and Back to Decreased Immune Surveillance (Journal of AIDS & Clinical Research) * SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade (Nature) * TWiV 1265: mRNA vaccines make cancer treatment great again (microbeTV: TWiV 1265) * Viral Infections and Risk of Cardiovascular Disease (Journal of the American Heart Association) * Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service) * Three large turkey farms in Minnesota hit with H5N1 avian flu (CIDRAP) * Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026 (NEJM) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles vaccine recommendations from NYP (jpg) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: Cliff notes (CDC FluView) * ACIP Recommendations Summary (CDC: Influenza) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Diseases (Yale School of Public Health) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Safety, Tolerability, and Immunogenicity of Revaccination With mRNA-1345, an mRNA Vaccine Against RSV, Administered 12 Months Following a Primary Dose in Adults Aged ≥50 Years (CID) * Vaccine effectiveness of a bivalent respiratory syncytial virus (RSV) pre-F vaccine against RSV-associated hospital admission among adults aged 75–79 years in England (LANCET: Infectious Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Association of 2024–2025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans (NEJM) * Durability of 2024-2025 COVID-19 Vaccines Against JN.1 Subvariants (JAMA: Internal Medicine) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1266 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains studies showing that SARS-CoV-2 mRNA vaccines improve life span of cancer patients on checkpoint immunotherapy, and broad immunity conferred by a vaccine central in A(H5) influenza antigenic space.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Immune 100 live at the Incubator * SARS-CoV-2 mRNA vaccines sensitize tumors to checkpoint immunotherapy (Nature) * People with some cancers live longer after mRNA vaccines (Nature) * Immune checkpoint inhibitors (NCI) * Broad immunity from influenza H5 vaccine (Nature) * Derek Smith on antigenic cartography (TWiV 99 at 2:53) * Letters read on TWiV 1265 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Kathy –Permethrin-treated baby wraps for malaria prevention and Phil Sharp and the Biotech Revolution Rich – Lydia Fairchild; Tetragametic Chimerism (NEJM) Alan – Warning Signs Vincent – radio.garden thanks to Kim!
Listener Pick Jamie – SkyCards by Flightradar24
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are distressed by the continuing government shutdown, first locally acquired chikungunya virus infection, President Trump’s suggestion for removing aluminum from vaccines, H5N1 isolation from backyard birds and turkey farms, and the suggestion of establishing an alternative to the CDC’s MMWR and asymptomatic measles infections before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the quarantining in the US due to measles, access to anti-influenza antiviral, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, if colchicine is effective for long COVID, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * New York health officials confirm state’s first locally acquired case of chikungunya virus (AP News) * Trump Rattles Vaccine Experts Over Aluminum (NY Times) * Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood (Annals of Internal Medicine) * Three large turkey farms in Minnesota hit with H5N1 avian flu (CIDRAP) * Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service) * Jeffrey Lee McLean (California.No) * California mpox cases raise concerns. But health officials say the risk remains low (AP News) * ‘Alternative’ to CDC’s Flagship Journal in the Works (MEDPAGE TODAY) * Measles without rash during acute febrile illness surveillance in Tanzania, 2023-2024 (CID) * Frustration grows amid measles outbreak quarantines across several states (NBC News) * More Than 100 Cases of Measles Reported in Utah and Arizona (NY Times) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine recommendations from NYP (jpg) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * ACIP Recommendations Summary (CDC: Influenza) * American Academy of Pediatrics * Flu and Children (CDC: Influenza (flu)) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) * Roche to sell flu pill for $50 to cash-paying US patients (Reuters) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Efficacy and safety of respiratory syncytial virus vaccines (Cochrane Library) * Estimated Vaccine Effectiveness for Respiratory Syncytial Virus–Related Acute Respiratory Illness in Older Adults (CID) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Effectiveness of Colchicine for the Treatment of Long COVID(JAMA Internal Medicine) * Reaching out to US house representative * Letters read on TWiV 1264 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews continuing US measles outbreak, host and genetic variations that regulate antibody responses to hepatitis C virus, and varicella-zoster reactivation and the risk of dementia.
Hosts: Vincent Racaniello, Alan Dove, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Mass firings at CDC (Time) * Measles cases continue to climb in US (NPR) * Immune 100 at The Incubator (Eventbrite) * Viral and host variations modulate antibody responses against HCV (Cell Rep) * VZV reactivation and risk of dementia (Nature Med) * Taking a shot at dementia (TWiV 1207) * Demented and crass (TWiV 1249) * Letters read on TWiV 1263 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – ‘Am I redundant?’: how AI changed my career in bioinformatics Brianne – OpenSpace and their YouTube Channel Alan – Coral City Camera – live view of a reef in Biscayne Bay, FL (and NPR story on it). Vincent – Neck pain relief exercises with Dr. Adam Fields
Listener Pick
Greg – AI: What could go wrong? and An AI System With Detailed Diagnostic Reasoning Makes Its Case
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed by the government shutdown, the firings at the CDC including EIS agents, H5N1 isolation from backyard birds and its stability in raw milk and cheese, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the quarantining of college students in the US due to measles, Japan’s declaration of a national influenza outbreak, effectiveness of the influenza and COVID vaccines, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, results from PLATCOV studies- still no antiviral activity attributed to ivermectin, where to go for answers to your long COVID questions, long COVID in pediatrics, patient reported outcomes from the STOP-PASC clinical trial, contacting your federal government representative to stop the assault on science and biomedical research and the listener reminder that measles vaccine in those with interferonopathy may result in severe adverse affects.
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Links for this episode * Trump Administration Lays Off Dozens of C.D.C. Officials (NY Times) * CDC walks back hundreds of firings as US shutdown persists (Yahoo News/ Reuters) * CDC battered by government shutdown firings, while some are rescinded (STAT 10) * Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service) * Flurry of H5N1 activity noted in commercial poultry, wild birds(CIDRAP) * H5N1 influenza virus stability and transmission risk in raw milk and cheese(Nature Medicine) * Hundreds of U.S. students quarantined amid measles outbreaks (NBC News) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Japan sees early flu activity, with school closures(CIDRAP) * Japan Declares Nationwide Flu Outbreak Following Early Surge in Cases (insightscare) * ACIP Recommendations Summary (CDC: Influenza) * American Academy of Pediatrics * Flu and Children (CDC: Influenza (flu)) * Effectiveness of influenza vaccination to prevent severe disease (CMI: Clinical Microbiology and Infection) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Efficacy and safety of respiratory syncytial virus vaccines (Cochrane Library) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents (The Pediatric Infectious Disease Journal) * Trump gets Covid vaccine and flu shot during second checkup of the year (NBC News) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)(eLife) * Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV) (LANCET: Infectious Diseases) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection (JAMA Internal Medicine) * Longitudinal patient-reported outcome trajectories in Long COVID: Findings from the STOP-PASC Clinical Trial (OFID) * Reaching out to US house representative * Severe Adverse Reaction to Measles Vaccine Due to Homozygous Mutation in the IFNAR2 Gene: A Case Report and Literature Review (Journal of Clinical Immunology) * Letters read on TWiV 1262 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV covers a MacArthur Award for Jason McLellan, 2025 Nobel Prizes in Physiology or Medicine, first treatment for Huntington’s Disease, structure of an archael dsDNA virus from head to tail, and discovery of a Legionella phage that explains a determinant of human disease.
Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Jason McLellan wins MacArthur Award (NPR) * 2025 Nobel Prizes Physiology or Medicine (Nobel Prizes) * Huntington Disease treatment (BBC) * Structure of archaeal tailed virus (Sci Adv) * Discovery of Legionella phage (Sci Adv) * Microbe of the Month: Legionella (Trends Micro) * Letters read on TWiV 1261 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Alan – Specimen of the last female Great Auk finally identified. Jolene – Ribosome studio on IG Vincent – Greater noctule bats prey on and consume passerines in flight
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about Jane Goodall’s death and the Nobel prize in Physiology/Medicine for understanding immune system control before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, if 2 doses of the influenza vaccine are better for protection of first season children, if COVID-19 negatively impacts pregnancy and the unborn child, efficacy of long-acting monoclonal antibody against symptomatic COVID-19, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, where to go for answers to your long COVID questions, long COVID in pediatrics, association of COVID-19 with new-onset vascular dementia and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Jane Goodall’s legacy: three ways she changed science (Nature) * They understood how the immune system is kept in check (The Nobel Prize) * Daniel Griffin: The Nobel Prize for Understanding Autoimmune Disease (WNYC: New York Public Radio) * Kennedy’s Ties to Ally Leading Vaccine Lawsuits Raise Ethical Concerns (NY Times) * Ebola outbreak in southern Congo shows signs of containment with no new cases, WHO reports (AP News) * Ebola Disease (WHO: African Region) * Premature baby dies from measles in Alberta as cases throughout province near 2,000(Global News) * DOH Issues Advisory After Measles Detection in City of Oswego Wastewater (Finger lakes dailynew.com) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Influenza-Associated Pediatric Deaths — United States, 2024–25 Influenza Season (CDC: MMWR) * ACIP Recommendations Summary (CDC: Influenza) * American Academy of Pediatrics * Flu and Children (CDC: Influenza (flu)) * Comparison of 2 Doses vs 1 Dose in the First Season Children Are Vaccinated Against Influenza (JAMA: Open Network) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Efficacy and safety of respiratory syncytial virus vaccines(Cochrane Library) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Neonatal outcomes among pregnant women with COVID-19 (BMC Pregnancy and Childbirth) * Safety and Efficacy of Pemivibart, a Long-Acting Monoclonal Antibody, for Prevention of Symptomatic COVID-19 (CID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) * Understanding Coverage Options (PAXCESS) * Retreatment With Nirmatrelvir/Ritonavir Following Return of COVID-19 Symptoms and SARS-CoV-2 Positivity (CID) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR) (LANCET: Infectious Diseases) * Prevalence and duration of clinical symptoms of pediatric long COVID (Frontiers in Pediatrics) * COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years(NPJ| dementia) Reaching out to US house representative * Letters read on TWiV 1260 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews experiments to understand infection, pathogenesis, and transmission of avian H5N1 influenza virus in goats, and identification of a cellular receptor for tick-borne encephalitis virus.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Public trust in science (Nature) * Culling of H5N1 ostriches in Canada (Science) * H5N1 in goats (Cell Rep) * Receptor for tick-borne encephalitis virus (Nature) * Letters read on TWiV 1259 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Astronomers find clues suggesting Planet Y Alan – A tower of worms wriggles like a single organism Vincent – The EPA Is Ending Greenhouse Gas Data Collection. Who Will Step Up to Fill the Gap?
Listener Picks Jay – Who Killed the Electric Car Douglas – Measles and Polio Down in the Schoolyard – Marsh Family parody
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about the ongoing Ebola outbreak in DRC, increases in screwworm diagnoses, a pertussis death in Mississippi before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, monoclonal antibody therapy against RSV, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, olfactory dysfunction following SARS-CoV-2 infection and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Ebola Disease (WHO: African Region) * Mexico sees 32% jump in flesh-eating screwworm cases since August as cases move north (Reuters) * Pediatric Pertussis Death Reported (Mississippi State Department of Health) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * Influenza-Associated Pediatric Deaths — United States, 2024–25 Influenza Season (CDC: MMWR) * ACIP Recommendations Summary (CDC: Influenza) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Nirsevimab Administration and RSV Hospitalization in the 2024-2025 Season (JAMA: Open Network) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Efficacy and safety of respiratory syncytial virus vaccines (Cochrane Library) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort (JAMA: Open Network) * Reaching out to US house representative * Letters read on TWiV 1258 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
From ESCV 2025, Vincent speaks with Elke Wollants about a project to identify SARS-CoV-2 and other viruses in toilet waste from airplanes.
Host: Vincent Racaniello Guest: Elke Wollants
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Links for this episode * Support science education at MicrobeTV * Laboratory for Clinical and Epidemiological Virology (KU Leuven) * Virologists in Greece (TWiV 1255 from ESCV) * Airplane wastewater surveillance for pathogens (SSRN) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains experiments to create genetically modified chickens that are resistant to avian influenza infection, and discovery of combination antiviral therapy for HTLV-1 infection.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Creating avian influenza virus resistant chickens (Nat Comm) * Antiretroviral therapy and apoptosis inhibition for HTLV-1 (Cell) * HTLV-1 infection (Cleveland Clinic) * Letters read on TWiV 1257 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Rich – Chagas Disease, an Endemic Disease in the United States Alan – Archive of molecular biology artifacts ends its long, strange trip at a museum Vincent – The World’s Oceans Are Hurtling Toward Breaking Point
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent travels to Thessaloniki, Greece to attend the 27th meeting of the European Society for Clinical Virology, where he speaks with Pamela Vallely, ESCV President, and Piotr Kramarz, Chief Scientist, European CDC, about the activities of ESCV and ECDC.
Host: Vincent Racaniello Guests: Piotr Kramarz and Pamela Vallely
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Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello lament the anti-vaccine, anti-science composition of the ACIP, US cases of Chagas disease, the Ebola vaccination campaign in the DRC, the death of an infant in LA due to measles complications (SSPE), before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, use of monoclonal antibodies against influenza, the lack of adverse effects of the COVID-19 mRNA in both non-pregnant and pregnant women, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, immune cell infiltration into the central nervous system during long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Northeast US states form health alliance in response to federal vaccine limits (Reuters) * MEETING OF THE ADVISORY COMMITTEE ON IMMUNIZATION PRACTICES (ACIP) (CDC: ACIP) * Viewpoint: Four tips for understanding this week’s ACIP meeting (CIDRAP) * From Data to Decisions: The Evidence Base for 2025 Fall/Winter Immunizations (CIDRAP) * Viewpoint: Four tips for understanding this week’s ACIP meeting (CIDRAP) * Vaccine Integrity Project (CIDRAP) * Chagas Disease, an Endemic Disease in the United States (CDC: Emerging Infectious Diseases) * Ebola vaccination begins in the Democratic Republic of the Congo (WHO: Democratic Republic of Congo) * Ebola Disease (WHO: African Region) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * L.A. child dies from complication of measles infection contracted in infancy (LA Times) * Tracking County-Level Measles Cases in the US (JAMA) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza (NEJM) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Moderna Announces Updated COVID-19 Vaccine Against LP.8.1 Variant Generates Strong Immune Response in Humans (Access Newswire) * Adverse events associated with COVID-19 vaccination or diagnosis among pregnant and non-pregnant women in the United States, 2021-2022 (International Journal of Infectious Diseases) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * PAXLOVID-nirmatrelvir and ritonavir : highlights of prescribing information (Pfizer) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer) * PAXCESSTM offers access and affordability options to patients prescribed PAXLOVIDTM (nirmatrelvir tablets; ritonavir tablets) (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * CSF immune cell alterations in women with neuropsychiatric Long COVID (JID) * Reaching out to US house representative * Letters read on TWiV 1254 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Vincent travels to Waterville Valley, NH to attend the Harvard virology retreat, where he speaks with Aaron Schmidt, Ben Gewurz, and Tatum Sass about their careers and their research on influenza virus, Epstein-Barr virus, and CAR-T cells.
Hosts: Vincent Racaniello Guests: Aaron Schmidt, Ben Gewurz, and Tatum Sass
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Links for this episode * Support science education at MicrobeTV * Harvard Program in Virology * Conserved sites on H1 and H3 HA (Sci Adv) * Antigenic drift expands viral escape (Immunity) * EBV LMP1 drives B cell oncometabolism (PLoS Path) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello discuss the continued Legionnaire’s outbreak in Harlem, invasive Asia longhorned tick and associated disease, potential Ebola outbreak in the Congo, Florida ending childhood vaccine mandates, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, SARS-CoV-2 spillover into household/domestic dogs, real data demonstrating the benefits of COVID-19 vaccines, states that increase access to COVID-19 vaccines, effective and availability to PAXLOVID, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, the beginning of numerous long COVID clinical studies and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Legionnaires’ Disease: In Harlem (NYC Health) * 2 dead, dozens sickened by Legionnaires’ disease in Westchester County: Officials (NBC News) * Invasive longhorned tick found for 1st time in New England (AP News) * First person bitten by east Asian longhorned tick (AP News) * Invasive, disease-carrying tick found in Maine, the farthest northeast it has been spotted (AP News) * Suspected cases rise in DR Congo Ebola outbreak (CIDRAP) * Ebola in the Democratic Republic of the Congo (CDC: Travelers’ Health) * Patricia Mazzei (NY Times) * Florida Moves to End Vaccine Mandates for Schoolchildren (NY Times) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * Influenza-Associated Hospitalizations During a High Severity Season — Influenza Hospitalization Surveillance Network, United States, 2024–25 Influenza Season (CDC: MMWR) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Risk factors for severe outcomes of respiratory syncytial virus infection in children (LANCET: Regional Health Europe) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Spillover of SARS-CoV-2 to domestic dogs in COVID-19–positive households: A one health surveillance study (Virus Research) * Pfizer and BioNTech Announce Topline Data Demonstrating Robust Immune Response With Their LP.8.1-Adapted COVID-19 Vaccine 2025-2026 Formula (Pfizer) * Minnesota, New York issue executive orders promoting access to COVID vaccines (CIDRAP) * No. 52: Declaring a Disaster in the State of New York Due to Federal Actions Related to Vaccine Access(NY State: Executive Order #52) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Patient-Reported Outcomes of Nirmatrelvir Treatment for High-Risk, Nonhospitalized Adults With Symptomatic COVID-19 (OFID) * Real-world effectiveness of nirmatrelvir-ritonavir against severe outcomes of COVID-19 in Taiwan (OFID) * PAXLOVID-nirmatrelvir and ritonavir : highlights of prescribing information (Pfizer) * Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer) * PAXCESSTM offers access and affordability options to patients prescribed PAXLOVIDTM (nirmatrelvir tablets; ritonavir tablets) (PAXCESS) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Clinical trials explore how Low-Dose Naltrexone could help people with Long COVID (The Sick Times) * Three clinical trials for Long COVID are testing JAK inhibitors to treat immune dysregulation (The Sick Times) * Research updates, July 29: Stellate ganglion blocks, may help reduce the severity of some symptoms of Long COVID and ME (The Sick Times) * New Long COVID and complex disease center at Mount Sinai set to be a leader in research, clinical care (The Sick Times) * RECOVER-TLC announces new Long COVID clinical trials, receives mixed reactions from patient community (The Sick Times) * Reaching out to US house representative * Letters read on TWiV 1252 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV re-issues our 100th episode which featured a discussion of viruses with David Baltimore, an exemplary scientist and Vincent’s exemplary mentor, who passed on 6 September 2025.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guest: David Baltimore
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Links for this episode * Support science education at MicrobeTV * David’s early papers on poliovirus and mengovirus RNA synthesis * Reverse transcriptase found by Baltimore and Temin (pdfs) * Nobel Prize in Physiology or Medicine 1975 * The David Baltimore asteroid belt * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews a study showing that the 2009 influenza pandemic virus disrupted biennial respiratory syncytial virus epidemics in northern Stockholm, and development of broad-spectrum synthetic carbohydrate receptors that inhibit viral entry of coronaviruses, filoviruses, and paramyxoviruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Florida will end all state vaccine mandates (Reuters) * New West Coast Health Alliance (Gov Newsome) * COVID vaccines to be more accessible in NY State (CBSNews) * Colorado makes COVID vaccines accessible (Denver Post) * Massachusetts makes COVID vaccines accessible (Boston dot com) * Viral interference disrupts RSV biennial pattern (Nat Comm) * Broad-spectrum antiviral carbohydrate receptors (Science Adv) * Pedantry about ‘in cellulo‘ (Protocol Online) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Revolutionary Bee “Superfood” Could Save Collapsing Colonies (U Oxford) Kathy – Margaret W. Rossiter, Who Discovered Women of Science, Dies at 81 Rich – Scientists track humpback whale migration with help from AI (Happywhale) Alan – You’re probably using the wrong dictionary (Alan’s first work of fiction) Vincent – Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Child with No Known Exposure
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello is shocked by COVID vaccine restrictions and uncertainties such as pharmacy stock, the ACIP meeting roster and whether it guidance is legal, 3 new ACIP members all anti-vaccine, ending of childhood vaccine mandates in Florida, the continued Legionnaire’s outbreak in Harlem, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, cardia benefits of the influenza vaccine, presence of SARS-CoV-2 antibodies in breast milk following vaccination, the use of antiviral nasal sprays to treat COVID 19, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Can You Still Get the Covid Shot? (NY Times) * Meeting of the Advisory Committee on Immunization Practices (Federal Register) * Cassidy Calls for Vaccine Committee Meeting to be Postponed Following CDC Departures(US Senate Committee on Health, Education, Labor and Pensions) * Catherine Stein (Brownstone Institute) * CIP to review COVID, hep B, and MMRV vaccine recommendations at September meeting (CIDRAP) * Kennedy plans to add new members to an influential vaccine advisory panel. * (NY Times) * Patricia Mazzei (NY Times) * The Steep Cost of Ron DeSantis’s Vaccine Turnabout (NY Times) * Florida Moves to End Vaccine Mandates for Schoolchildren(NY Times) * Legionnaires’ Disease: In Harlem(NYC Health) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2025–26 Influenza Season (CDC: MMWR) * ACIP Recommendations Summary (CDC: Influenza (Flu)) * Flu vaccines show benefits for the heart in new studies (CIDRAP) * Risk of Myocarditis or Pericarditis With High-Dose vs Standard-Dose Influenza Vaccine (JAMA: OPEN) * High-Dose vs Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults (JAMA: Cardiology) * Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II) (LANCET) * Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Respiratory Syncytial Virus Immunization Coverage Among Infants Through Receipt of Nirsevimab Monoclonal Antibody or Maternal Vaccination (CDC: MMWR) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * SARS-CoV-2 Vaccine-Elicited Antibody Responses in Human Milk (Journal of Pediatric Infectious Diseases Society) * Interferon-α Nasal Spray Prophylaxis Reduces COVID-19 in Cancer Patients: A Randomized, Double-Blinded, Placebo-Controlled Trial (CID) * Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections (JAMA Internal Medicine) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Effect of Metformin on the Risk of Post-coronavirus Disease 2019 Condition Among Individuals With Overweight or Obese (CID) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia: Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative Florida moves to kill vaccine mandates; state surgeon general slams them as ‘slavery’ (Herald-Tribune) * Letters read on TWiV 1250 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews the major shakeup in CDC leadership, herpes simplex virus infection doubles the risk of dementia, and the prototypic crAssphage is a linear phage-plasmid.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * CDC director ousted? (CNN) * Herpes simplex infection doubles risk of dementia (J Alzheimers Res) * Fishing for viruses in senile (TWiV 519) * Epstein-Barr virus and MS (TWiV 869) * Taking a shot at dementia (TWiV 1207) * crAssphage is linear phage-plasmid (Cell Host Microbe) * Crassvirales (MDPI) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Research posts on Bluesky are more original — and get better engagement Rich – Rabbits With Hornlike Growths Are Hopping Around Colorado. Are They OK? (Wiki on Shope papilloma virus) Jolene – Lessons Learned: Stories from Women Leaders in STEM Vincent – What Makes This Song Great? “Smells Like Teen Spirit” Nirvana
Listener Picks Lori – Tolga bat hospital Emmett – An author recommendation: Peter Watts
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed about the recent attack on public health the firing of the director of the CDC as well as resignation of 3 others members of the agency’s leadership, the continued Legionnaire’s outbreak in Harlem, suspension of Ixchiq the Chikungunya virus attenuated infectious vaccine, the first US case of New World screwworm before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, association Guillian-Barré syndrome with RSV vaccination, guidelines for using RSV vaccines, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, the American College Obstetricians and Gynecologists recommendations for the COVID, RSV and influenza vaccines, FDA approval letters for Pfizer, moderna and Novagax COVID vaccines including label changes for use in those between 5 through 64 years, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * White House Says New C.D.C. Director Is Fired, but She Refuses to Leave (NY Times) * CDC director refuses to leave after White House order (BBC) * Legionnaires’ Disease: In Harlem(NYC Health) * New York City Health Department Provides Update on Community Cluster of Legionnaires’ Disease in Central Harlem(NYC Health: Promoting and protecting the City’s health) * FDA Update on the Safety of Ixchiq (Chikungunya Vaccine, Live) (FDA) * Vimkunya (Bavarian Nordiac) * U.S. and Panama for the control of the Screwworm pest (COPEG) * Rare human case of flesh-eating parasite New World screwworm identified in US(CNN) * USDA Announces Sweeping Plans to Protect the United States from New World Screwworm (USDA) * HHS details New World screwworm response after human case(CIDRAP) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Tracking Measles Cases in the U.S. (Johns Hopkins) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles vaccine recommendations from NYP (jpg) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to frailty score (JID) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * ENFLONSIA: novel drug approvals 2025 (FDA) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Evaluation of Guillain-Barré Syndrome (GBS) following Respiratory Syncytial Virus (RSV) Vaccination Among Adults 65 Years and Older (FDA) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Veering from CDC, ACOG recommends maternal vaccination against COVID-19 (CIDRAP) * ACOG Releases Updated Maternal Immunization Guidance for COVID-19, Influenza, and RSV (American College of Obstericians and Gynecologists) * COVID-19 Vaccination Considerations for Obstetric–Gynecologic Care (American College of Obstericians and Gynecologists) * Pfizer and BioNTech’s COMIRNATY® Receives U.S. FDA Approval for Adults 65 and Older and Individuals Ages 5 through 64 at Increased Risk for Severe COVID-19 (Pfizer) * COMIRNATY approval letter (FDA) * Moderna Receives U.S. FDA Approval for Updated COVID-19 Vaccines Targeting LP.8.1 Variant of SARS-CoV-2 (FEEDS) * SPIKEVAX approval letter (FDA) * Novavax’s Nuvaxovid 2025-2026 Formula COVID-19 Vaccine Approved in the U.S (Novavax) * NUVAXOVID approval letter (FDA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reaching out to US house representative * Letters read on TWiV 1248 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Stanley Plotkin joins TWiV to recount his career as a vaccinologist, having participated in the development of vaccines for polio, rabies, and rubella, and his thoughts on the current anti-science, anti-public health, and anti-vaccine climate.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler Guest: Stanley A. Plotkin
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Stanley Plotkin (History of Vaccines) * Talking about vaccines with Dr. Plotkin (CHOP) * Path to eradication of rubella (Vaccine) * Status of cytomegalovirus vaccine (J Inf Dis) * Human diploid cell vaccines (Dev Biol Stand) * IPV an essential part of polio eradication (Clin Inf Dis) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses outbreaks of Vibrio vulnificus and Legionnaire’s disease in Harlem, the role of the American Association of Pediatrics defining immunization practices, before Dr. Griffin deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, effective of the high and low does influenza vaccines, association Gullian-Barre syndrome with RSV vaccination, guidelines for using RSV vaccines, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, vascular aging after COVID-19 and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Department of Public Health alerts public to rare Vibrio vulnificus bacteria in coastal waters (Mass.gov) * Legionnaires’ Disease: In Harlem (NYC Health) * Ivermectin to Control Malaria (NEJM) * AAP has been leading voice on childhood vaccine recommendations since 1930s * (American Academy of Pediatrics) * The American Academy of Pediatrics Releases Its Own Evidence-Based Immunization Schedule (American Academy of Pediatrics) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Health Ministry says unvaccinated 18-month-old dies of measles (Times of Israel) * Ten countries in the Americas report measles outbreaks in 2025 (PAHO: Pan American Health Organization) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles vaccine recommendations from NYP (jpg) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Relative effectiveness of high-dose versus standard-dose influenza vaccine against hospitalizations and mortality according to frailty score (JID) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * ENFLONSIA: novel drug approvals 2025 (FDA) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) * Evaluation of Guillain-Barré Syndrome (GBS) following Respiratory Syncytial Virus (RSV) Vaccination Among Adults 65 Years and Older (FDA) * Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) * Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study (European Heart Journal) * Reaching out to US house representative * Letters read on TWiV 1246 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews fradulent science becoming an industry, FDA may not authorize Pfizer COVID vaccine for young kids, Kennedy won’t push strict pesticide regulations conserved betacoronavirus sequences recognized by human T cells, and Bispecific antibodies protect against herpes recurrent disease.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Frontiers in Comparative Systems Virology * Fradulent science becomes an industry (Science) * FDA may not authorize Pfizer COVID vaccine for young kids (CIDRAP) * Kennedy Won’t Push Strict Pesticide Regulations (NY Times) * Conserved betacoronavirus sequences recognized by human T cells (Cell) * Bispecific antibodies protect against herpes recurrent disease (Cell Rep) * Letters read on TWiV 1245 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – New Study Suggests Using AI Made Doctors Less Skilled at Spotting Cancer Alan – Save the Microbes effort gets off the ground Vincent – Dr. Vinay Prasad’s Catch-22: The Only Way He Can Truly Succeed at His Job is to Get Fired Again
Listener Picks Chaim – “Virus Hunters” by Greer Williams Bridget – Wave Life Sciences and their potential treatment for Alpha-1 antitrypsin deficiency
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses Vijay Prasad’s return to the FDA, revoking of COVID vaccine authorization for young children, the Legionnaires’ outbreak in Harlem, the new labeling requirements for Ixchiq, the infectious attenuated Chikungunya vaccine and the importation of H5 influenza virus in Antarctica, before Dr. Griffin deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, guidelines for treating COVID-19, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, the association of “virus rebound” and post-acute sequelae among hospitalized patients, how virus infection particularly influenza and SARS-CoV-2 may ‘re-activate’ dormant cancer cells and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Prasad returns to the FDA (Washington Post) * Pfizer Covid vaccine for young children may not be renewed by FDA (The Guardian) * Report suggests FDA may not reauthorize Pfizer COVID vaccine for young kids (CIDRAP) * Factors Associated With Pediatric COVID-19 Mortality: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study (Journal of Pediatric Infectious Diseases Society) * Legionnaires’ Disease: In Harlem (NYC Health) * Recommended Pause in Use of Ixchiq (Chikungunya Vaccine, Live) in Individuals 60 Years of Age and Older While Postmarketing Safety Reports are Investigated (FDA) * FDA Removes Recommended Pause in Use and Approves Required Updated Labeling (FDA) * Chikungunya Vaccines (CDC: Chikungunya virus) * Chikungunya in China (CDC: Travelers’ Health) * Travelers’ health notices (CDC: Travelers’ Health) * Areas at Risk for Chikungunya (CDC: Chikungunya virus) * Adjuvanted recombinant zoster vaccine is effective against herpes zoster ophthalmicus, and is associated with lower risk of acute myocardial infarction and stroke in adults aged ≥50 years (CID) * Tracking HPAIV H5 through a geographic survey of Antarctic seabird populations * (Scientific Reports) * Report details first suspected H5 avian flu detections in seabirds in Antarctica(CIDRAP) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * ENFLONSIA: novel drug approvals 2025 (FDA) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Pemivibart for Pre-exposure Prophylaxis, Vilobelimab for Critical Illness, and Abatacept or Infliximab for Severe or Critical Illness (CID) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * TWiV 1243: Capitalism, COVID and Cancer (MicrobeTV) * Respiratory viral infections awaken metastatic breast cancer cells in lungs(Nature) * Reaching out to US house representative * Letters read on TWiV 1244 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV discusses the latest worrisome Executive Order on oversight of federal grantmaking, RFK Jr winds down mRNA viral vaccine development, Lenacapavir, a drug for AIDS prevention and treatment, and how respiratory virus infections awaken dormant metastatic breast cancer cells in lungs.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Oversight of Federal grantmaking (Whitehouse.gov) * Grantmaking gets a Christofascist (Rasmussen Retorts) * HHS winds down mRNA vaccine development (HHS) * Lives saved by COVID vaccines (JAMA) * Lenacapavir review (Bicochem Pharm) * UNAIDS urges Gilead to lower price of lenacapavir (UNAIDS) * Gilead and price gouging (Wikipedia) * Respiratory virus infections awaken metastatic breast cancer (Nature) * Letters read on TWiV 1243 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Xkcd: Geologic Periods Rich –Old Man’s War by John Scalzi Alan –The Broken Earth trilogy by N. K. Jemisin Vincent – Cacio e pepe: Good Food pasta recipe sparks fury in Italy
Listener Pick Linda – DNA captured in air could identify life forms
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello re-address the dangers of drinking raw milk, the Legionnaire’s outbreak in Harlem and results of a vaccine knowledge survey done by emergency departments before Dr. Griffin deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, reports of influenza-associated acute necrotizing encephalopathy or neuropsychiatric events in children, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, the effectiveness of Pfizer and MODERNA vaccines against the JN.1 variant, risk of children developing severe disease from SARS-CoV-2 infection, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, the association of “virus rebound” and post-acute sequelae among hospitalized patients, effectiveness of COVID-19 vaccines against long COVID, predictors for distinct COVID-19 sequelae including immune disturbances and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Florida Department of Health Provides Update on Raw Milk(Florida Health) * Raw milk linked to 21 E coli, Campylobacter infections in Florida (CIDRAP) * Legionnaires’ Disease: In Harlem (NYC Health) * NYC health officials report Harlem Legionnaires’ outbreak(CIDRAP) * Emergency Department Survey of Vaccination Knowledge, Vaccination Coverage, and Willingness to Receive Vaccines in an Emergency Department Among Underserved Populations (CDC: MMWR) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) Measles vaccine recommendations from NYP (jpg) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Influenza-Associated Acute Necrotizing Encephalopathy in US Children (JAMA) * Influenza With and Without Oseltamivir Treatment and Neuropsychiatric Events Among Children and Adolescents(JAMA Neurology) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * ENFLONSIA: novel drug approvals 2025 (FDA) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Effectiveness of the BNT162b2 and mRNA-1273 JN.1-adapted vaccines against COVID-19-associated hospitalisation and death: a Danish, nationwide, register-based, cohort study (LANCET: Infectious Diseases) * Hospitalization for COVID-19 and Risk Factors for Severe Disease Among Children: 2022–2024 (Pediatrics) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Metformin and Time to Sustained Recovery in Adults With COVID-19 (JAMA Internal Medicine) * Drug interaction checker (University of Liverpool) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * SARS-CoV-2 rebound and post-acute mortality and hospitalization among patients admitted with COVID-19(Nature Communications) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Effectiveness of COVID-19 vaccines against post COVID-19 condition/long COVID (CMI: Clinical Microbiology and Infection) * Precision Symptom Phenotyping Identifies Early Clinical and Proteomic Predictors of Distinct COVID-19 Sequelae (JID) * Systemic and SARS-CoV-2 specific Immune Disturbances in Individuals With Post–COVID Syndrome (JID) * Reaching out to US house representative * Letters read on TWiV 1242 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reports the administration putting a choke hold on billions of NIH health research funding, US Senators tell scientists they want to protect the NIH budget, then review a classic experiment showing the mechanism of DNA replication, and explain how jumbo phage DNA is transcribed in a membrane-bound compartment before transfer into proteinaceous “nucleus” compartment.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, Jolene Ramsey, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV 5:13 * Chokehold on billions in NIH funding (WSJ) * Senators want to protect NIH budget (Nature) * Replication of DNA in E. coli (PNAS) * Biography of Franklin Stahl (DNA Learning Center) * Franklin Stahl, 95 (Caltech Magazine) * FW Stahl dies (NY Times) * Requiem for a machine (Small Things Considered) * Membrane and protein bound organelles during phage infection (Cell Host Micr) * Letters read on TWiV 1241 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Benefits of interacting with Nature Brianne – “Why Trust Science” Essay Kathy – Dental floss delivery of vaccines to mice Rich – The Monk in the Garden Jolene – JWST COSMOS-Web Interactive Map viewer Vincent –New Injectable Recommended by Europe for HIV Prevention
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about the recent Salmonella typhimurim outbreak, the ousting of another CBER director, confirmation of a new CDC director and results of a recent pool about vaccine safety and trust before Dr. Griffin deep dives into recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, a new anti-influenza antibody that can be combined with neuraminidase inhibitors, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, the effectiveness of Sinopharm’s COVID-19 vaccine, where to find PEMGARDA, safety of the JN.1 updated vaccine, long COVID treatment center, where to go for answers to your long COVID questions, the prevalence of cardiac and pulmonary abnormalities found via medical imaging following COVID-19 and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Outbreak of Salmonella Typhimurium Infections Linked to Commercially Distributed Raw Milk (CDC: MMWR) * Top F.D.A. Official Resigns UnderPressure (NY Times) * In a first, the Senate confirms a new CDC director (NPR) * KFF Tracking Poll on Health Information and Trust: Vaccine Safety and Trust (KFF) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Effects of baloxavir marboxil plus neuraminidase inhibitor versus neuraminidase inhibitor in high-risk patients hospitalized with severe influenza: a post hoc analysis of the Flagstone trial (OFID) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * ENFLONSIA: novel drug approvals 2025 (FDA) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Safety of JN.1-Updated mRNA COVID-19Vaccines (JAMA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Prevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients (Journal of Nuclear Medicine) * Reaching out to US house representative * Letters read on TWiV 1240 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains a cohort study of over one million Danish children which shows no evidence supporting an increased risk for autoimmune, atopic or allergic, or neurodevelopmental disorders associated with early childhood exposure to vaccines with aluminum-base adjuvants, and a study of antibodies induced by mRNA-1273 and NVX-CoV2373 COVID-19 vaccines which show that polyclonal antibodies against a single site on the spike N-terminal domain show immunodominance, high diversity, and limited cross-reactivity, indicating the need to direct antibody responses away from this site.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episode * Support science education at MicrobeTV * No chronic effects of aluminum-based adjuvants in vaccines (Ann Int Med) * Aluminum in vaccines (CHOP) * Structural serology of antibody responses to COVID vaccines (Cell Rep) * Letters read on TWiV 1239 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – MHC Class I Antigen Presentation Video Alan – We Become What We Behold Vincent –New Injectable Recommended by Europe for HIV Prevention
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello chat about how flies and milk-snatching might contribute to influenza virus H5N1 among dairy cattle, the recent pertussis oubreak and measles epidemic before Dr. Griffin discusses monoclonal antibody therapy can enrich for RSV variants before deep diving into recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, the effectiveness of Sinopharm’s COVID-19 vaccine, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how mast cell activation can enhance long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Flies, ‘milk snatching’ among H5N1 transmission contributors in dairy cattle(CIDRAP) * H5N1 virus invades the mammary glands of dairy cattle through “mouth-to-teat” transmission (NSR: National Science Review) * Mississippi warns of steep increase in pertussis cases (CIDRAP) * MSDH Issues Pertussis Alert (Mississippi State Department of Health) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * ENFLONSIA: novel drug approvals 2025 (FDA) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Respiratory Syncytial virus Strain Evolution and Mutations in Western Australia in the Context of Nirsevimab Prophylaxis (OFID) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * Real-world Evaluation of the Effectiveness of Sinopharm COVID-19 Vaccine Against Symptomatic COVID-19 in an Omicron-Dominant Setting in Mozambique (CID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Mast cell activation symptoms are prevalent in Long-COVID (International Journal of Infectious Diseases) * Using the Right Criteria for MCAS (Current Allergy and Asthma Reports) * Utility of glucagon-like-peptide-1-receptor agonists in mast cell activation syndrome (The American Journal of the Medical Sciences) * Reaching out to US house representative * Letters read on TWiV 1238 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
From the 2025 annual meeting of the American Society for Virology, Charlie Rice, 2020 Nobel Laureate in Physiology or Medicine, talks with Vincent and Kathy about his career and the scientific difficulties he and his laboratory encountered in their attempts to achieve replication of hepatitis C virus in cells in culture.
Hosts: Vincent Racaniello and Kathy Spindler Guest: Charlie Rice
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Links for this episode * Support science education at MicrobeTV * 2020 Nobel Prize (Nobel Prizes) * Hepatitis C human challenge study (Lancet Gastro Hepatol) * Rat hepacivirus mouse model for hepatitis C (Hepatol) * Replication of hepatitis C virus in cells in culture (Science) * Lessons from domestication of HCV (Curr Opin Virol)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello have a morning chat about the measles epidemic and H5N1 in cows before Dr. Griffin discusses how vaccination associates with reduced dementia risk before deep diving into recent statistics on measles epidemic, RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, a potential new influenza antiviral drug, whether or not the NB.1.8.1 variant should be included in the fall 2025 vaccines, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, associaton of remesdivir administration and long-term sequelae and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Measles vaccine recommendations from NYP (jpg) * The impact of highly pathogenic avian influenza H5N1 virus infection on dairy cows (Nature) * Avian flu exacts heavy financial toll on dairy industry, report says(CIDRAP) * Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines (Journal of Experimental Medicine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * ENFLONSIA: novel drug approvals 2025 (FDA) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Systematic review and expert consensus on the use of long-acting monoclonal antibodies for prevention of respiratory syncytial virus disease: ARMADA (Advancing RSV Management And Disease Awareness) Taskforce (OFID) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID cases likely rising in half of states, CDC estimates(CBS News) * Estimated COVID-19 Periodicity and Correlation with SARS-CoV-2 Spike Protein S1 Antigenic Diversity, United States (Emerging Infectious Diseases) * Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * Estimated COVID-19 Periodicity and Correlation with SARS-CoV-2 Spike Protein S1 Antigenic Diversity, United States (Emerging Infectious Diseases) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * This CDC Resignation Should Scare You (Substack: Beyond the Noise) * ACIP: COVID-19–Associated Hospitalizations — COVID-NET, April 2025 Update (CDC: National Center for Immunization and Respiratory Diseases)) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug treatments for mild or moderate covid-19: systematic review and network meta-analysis (BMJ) * Drug interaction checker (University of Liverpool) * Paxlovid (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Extended nirmatrelvir–ritonavir treatment durations for immunocompromised patients with COVID-19 (EPIC-IC) (LANCET: Infectious Diseases) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Invivyd and Leading Researchers Form SPEAR (Spike Protein Elimination and Recovery) Study Group to Assess the Effects of Monoclonal Antibody Therapy for Long COVID and COVID-19 Post-Vaccination Syndrome (INVIVYD) * Reaching out to US house representative * Letters read on TWiV 1236 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
David Barton, Brian Kemp, and Olve Peersen join TWiV to discuss RNA recombination among enteroviruses and its role in foiling poliovirus eradication.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Guests: David Barton, Brian Kempf, and Olve Peersen
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Links for this episode * Support science education at MicrobeTV * Enterovirus C recombination groups (J Virol) * Poliovirus polymerase L420 facilitates RNA recombination (J Virol) * Picornavirus RNA recombination counteracts error catastrophe (J Virol) * Extended primer grip and picornavirus RNA recombination (J Virol) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello note that history is being rewritten for justification of changes in COVID vaccine guidelines including myocarditis incidence and the Great Barrington Declaration ignoring presentations at the April 2025 ACIP, the response by the medical community to these changed guidelines, before Dr. Griffin discusses how vaccination associates with reduced dementia risk before deep diving into recent statistics on measles epidemic, RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, a potential new influenza antiviral durg, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, associaton of remesdivir administration and long-term sequelae and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * FDA to look again at myocarditis risk from mRNA-based COVID-19 jabs in young men (FirstWord PHARMA) * Great Barrington Declaration (Great Barrington Declaration) * Debunking Herd Immunity: A Review of We Want Them Infected (Global Autoimmune Institute * Scientific consensus on the COVID-19 pandemic (LANCET) * John Snow, memo vaccines-plus strategy (John Snow Memorandum) * This CDC Resignation Should Scare You (Substack: Beyond the Noise) * COVID-19–Associated Hospitalizations — COVID-NET, April 2025 Update (CDC: National Center for Immunization and Respiratory Diseases) * Leading Medical Professional Societies, Patient Sue HHS, Robert F. Kennedy, Jr. for Unlawful, Unilateral Vaccine Changes (ACP: American College of Physicians) * Medical groups sue HHS, Kennedy over COVID vaccine policy changes(CIDRAP) * Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections (Vaccines) * Influenza vaccination reduces dementia risk (Ageing Research Reviews) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * New Mexico announces measles outbreak in a county detention facility(AP News) * Weekly measles and rubella monitoring (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Cidara Therapeutics Announces Positive Topline Results from its Phase 2b NAVIGATE Trial Evaluating CD388, a Non-Vaccine Preventative of Seasonal Influenza (CIDARA Therapeutics) * Experimental flu drug may protect better than flu vaccines(CIDRAP) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Readmission Following Respiratory Syncytial Virus Hospitalization among Children
TWiV covers FDA Director overriding scientists on COVID shots, NIH funded science must now be free to read instantly, Trump cuts subscriptions to Springer Nature journals, UK and Gates make up for US money withdrawn from GAVI, US defunding USAID could lead to 14 million deaths by 2030, then reviews research on how host IL1 genetics regulates Epstein-Barr virus reactivation and long COVID, and enhanced antiviral capacity of bat innate immunity.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * FDA official overrides scientists on COVID shots (NYTimes) * NIH funded science must be immediately open access (Nature) * Trump cuts journal subscriptions for NIH (Science) * Donors make up GAVI US shortfall (Reuters) * USAID defunding will lead to 14 million deaths (CIDRAP) * SARS-CoV-2, IL1, Epstein-Barr virus and long COVID (Cell Rep) * Bat innate immunity (Nat Comm) * Letters read on TWiV 1233 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Rich – Unraveling Mendel’s final mysteries: A genomic retelling of pea genetics (Thanks, Kathy!) (Original article) Alan – Winners of Nature’s 2025 “Scientist at Work” photo competition Vincent –Signs of AI-generated text found in 14% of biomedical abstracts last year
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are shocked at how vaccine safety is undercut by misrepresenting thimerosal safety, its removal from vaccines, and how CBER director Vinay Prasad overruled his advisors for the administration of COVID vaccines to pregnant people knowingly compromising their health, before Dr. Griffin reviews recent statistics on measles epidemic, RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, association of long COVID and cognitive changes as well as the development of type I diabetes and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * Thimerosal and Vaccines (FDA) * Thimerosal-containing vaccines and neurodevelopmental outcomes (CDC) * Thimerosal and Vaccines (CDC: Vaccine safety) * WHO says ‘no evidence of harm’ from thimerosal (Reuters) * RFK Jr.’s Vaccine Panel Has a New Approach: Question Everything (Wall Street Journal) * COVID-19 infection poses higher risk for myocarditis than vaccines (American Heart Association) * Top F.D.A. Official Overrode Scientists on Covid Shots (NY Times) * Who Sets the Immunization Schedule? (CDC: Vaccines for your children) * Recommended Child and Adolescent Immunization Schedule for ages 18 years or younger (CDC) * H5 bird flu: current situation (CDC: Avian Influenza) * Assessing the transmissibility and outbreak risk of measles in the United States, 2024 – 2030 (JID) * Proof of a measles vaccine for travelers coming from various countries, including the United States (US Embassy in Honduras) * More measles outbreaks put US total within single digits of modern-day record (CIDRAP) * Epidemiological Update – Measles in the Americas Region – 1 July 2025 (PAHO) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * New Mexico announces measles outbreak in a county detention facility (AP News) * Weekly measles and rubella monitoring (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Influenza Vaccination During Pregnancy and Infant Influenza in the First 6 Months of Life (Obstetrics & Gynecology) * Influenza vaccination in Japanese children, 2024/25: Effectiveness of inactivated vaccine and limited use of newly introduced live-attenuated vaccine (Vaccine) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Novel Drug Approvals for 2025 (FDA) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Independent assessment of the origins of SARS‑CoV‑2(WHO) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV) * Estimated 2023-2024 COVID-19 Vaccine Effectiveness in Adults (JAMA) * RECOVID: Retrospective Observational Study of Renal Outcomes and Long-Term Mortality in Patients With COVID-19-Associated AKI, A Comparison Between Vaccinated and Unvaccinated Patients (Kidney Medicine) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * COVID-19 and Cognitive Change in a Community-Based Cohort(JAMA) * SARS-CoV-2 infection and new-onset type 1 diabetes in the post-acute period among children and young people in England(Diabetic Medicine) Reaching out to US house representative * Letters read on TWiV 1232 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV discusses Sen. Cassidy calling for ACIP meeting delay, RFK Jr. abandons GAVI, millions of children at risk as global vaccination rates fall, RFK Jr. grilled by Congress, autism rates have increased 60-fold due to changed definitions, deep mutational scanning of rabies virus glyoprotein, and and proton gradient and incomplete TCA cycle in a giant virus.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Sen. Cassidy calls for ACIP delay (NYTimes) * RFK Jr. stops GAVI funding (NYTimes) * Global vaccination rates drop, millions of children at risk (Guardian) * Autism rates have increased 60-fold, here’s why (NYTimes) * Deep mutational scanning of rabies virus glycoprotein (Cell Host Micr) * Giant virus with proton gradient and partial TCA cycle (ISME J) * Why cells are powered by proton gradients (Scitable) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela –27 new, exciting, and blobby species discovered in the Peruvian rainforest! Brianne – Encounters in the Milky Way Rich – Where to go for accurate, up-to-date vaccine information Vincent – The members of RFK Jr.’s new vaccine committee have published little on vaccines
Listener Picks Charles – Vaccine Advice, Vandalized Ken – Golden Goose Awards
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello are alarmed at how RFK is breaking his promise of not altering vaccine policies, and nonexistent data and studies are used by members of the ACIP to make changes to immunization practices in the absence of a CDC director, justification for not honoring the US commitment to GAVI and global public policies including support of routine childhood immunizations, placing millions of children at risk for the return of vaccine preventable diseases including polio outbreaks in Pappa New Guinea and increased circulation of wildtype type 1 poliovirus, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, approval of Merck’s anti-RSV mRNA monoclonal antibody, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, changes in COVID mRNA vaccine labeling and reframing of the science around the vaccine, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, and contacting your federal government representative to stop the assault on science and biomedical research
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Links for this episode * Jake Scott (Stanford University) * Vaccine Randomized control trials (Bradspellberg.com) * Vaccine RCT spreadsheet aims to show the data, dispel myths about vaccines (CIDRAP) * Vaccines-rcts (Bradspellberg.com) * CDC’s upcoming vaccine advisory meeting set up to sow distrust in vaccines (CIDRAP) * Next ACIP meeting (CDC: ACIP) * June meeting: MEETING OF THE ADVISORY COMMITTEE ON IMMUNIZATION PRACTICES (ACIP) (CDC: ACIP agenda) * Robert F Berman, PhD (UC Davis Health: Department of Neurological Surgery) * Transparency = nonexistent data: CDC advisers appears to cite nonexistent study to support claims about risk of vaccine preservative (CNN) * A C.D.C. Committee Just Voted Against Flu Shots With This Preservative. Is It Safe? (NY Times) * CDC vaccine advisory committee to review long-approved immunizations (STAT News) * Newly appointed CDC vaccine advisory committee holds first meeting, stirs more controversy (CIDRAP) * FDA approves clesrovimab to protect infants during first RSV season (Contemporary Pediatrics) * ACIP updates: Committee recommends clesrovimab for RSV, reaffirms routine influenza vaccination (Contemporary Pediatrics) * Susan Monarez (Wikipedia) * Robert F Kennedy Jr (Wikipedia) * Centers for Disease Control and Prevention (Wikipedia) * Who is in charge at the CDC (CDC: About CDC) * Do children REALLY need to be vaccinated? (Wall Street Journal) * U.S. Adults’ Views on Routine Childhood Vaccination (Harvard Opinion Research Program) * RFK Jr. declares US withdrawal from GAVI (YouTube) * Kennedy Withdraws U.S. Funding Pledge to International Vaccine Agency (NY Times) * Millions of children at risk as global vaccine rates fall (Guardian) * Global, regional, and national trends in routine childhood vaccination coverage from 1980 to 2023 with forecasts to 2030 (LANCET) * Polio this week: 47 WPV1 positive environmental samples this week! (GPEI) * H5 bird flu: current situation (CDC: Avian Influenza) * Cambodia logs fifth death from H5N1 avian flu as USDA weighs poultry vaccination (CIDRAP) * Cambodia reports 6th H5N1 bird flu case this year(BNO News) * USDA develops potential plan to vaccinate poultry for bird flu (Reuters) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Novel Drug Approvals for 2025 (FDA) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * Episode 184: Fool’s Gold: Reframing the Science…..reframing? (Apple Podcasts: Osterholm Update) * Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes (Journal of Proteome Research) * FDA COVID mRNA vaccine labeling update (FDA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Stellate Ganglion Block for the Treatment of COVID-19−Induced Parosmia (JAMA Otolaryngology-Head& Neck Surgery) * Reaching out to US house representative * Letters read on TWiV 1230 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Rich travels to Dubrovnik for the European Congress of Virology 2025 and Vincent joins via Zoom to speak with Stéphane Blanc, Vanda Juranić Lisnić, and Elisabeth Puchhammer-Stöckl about their work on plant viruses, cytomegalovirus, and Epstein-Barr virus.
Hosts: Vincent Racaniello and Rich Condit Guests: Stéphane Blanc, Vanda Juranić Lisnić, and Elisabeth Puchhammer-Stöckl
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Links for this episode * Support science education at MicrobeTV * Assembled plant viruses move through plants (PLoS Path) * Genome formula of multipartite virus (PLoS Path) * Immune surveillance of cytomegalovirus in tissues (Cell Mol Immunol) * Cytomegalovirus and NK cells (Nat Commun) * Epstein-Barr virus and multiple sclerosis (J Clin Inves) * Epstein-Barr virus and lymphoproliferative disease (Transplant) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss in shock how RFK is breaking his promise of not altering vaccine policies by appointing new members of the ACIP, next ACIP meeting on guidelines for the COVID and RSV vaccines, circulation of “human insect viruses” including West Nile virus, and an outbreak of mpox on a cruise ship, and the ongoing measles outbreak before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, how to reduce the use of antibiotics for RSV and influenza infections in children, approval of the moderna RSV mRNA vaccine, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, contacting your federal government representative to stop the assault on science and biomedical research, and a shout out for the special episode of TWiV with David Tuller on long COVID and ME/CFS.
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Links for this episode * RFK Jr. is sabotaging the vaccine program. Here’s how to stop him (Washington Post) * Innovaciones Alumbra (Alumbra Innovaciones) * John T Walton (Wikiepedia) * Walmart (Wikipedia) * Sam Walton (Wikipedia) * Condé Nast (Wikipedia) * Christy Walton (Wikipedia) * Vaccine Integrity Project ( CIDRAP) * CIDRAP launches Vaccine Integrity Project (Twin Cities: University of Minnesota) * Next ACIP meeting (CDC: ACIP) * June meeting: MEETING OF THE ADVISORY COMMITTEE ON IMMUNIZATION PRACTICES (ACIP)(CDC: ACIP agenda) * West Nile Virus and Other Nationally Notifiable Arboviral Diseases — United States, 2023 (CDC: MMWR) * Clade II Mpox Infections Among Cruise Ship Passengers and Crew Members — United States, 2024 (CDC: MMWR) * H5 bird flu: current situation (CDC: Avian Influenza) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola) * Measles vaccine recommendations from NYP (jpg) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Pediatric antibiotic use associated with respiratory syncytial virus and influenza in the United States, 2008-2018 (JID) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Novel Drug Approvals for 2025 (FDA) * Effectiveness and impact of nirsevimab in Chile during the first season of a national immunisation strategy against RSV (NIRSE-CL) (LANCET: Infectious Diseases) * Safety, Tolerability, and Immunogenicity ofmRNA-1345 in Adults at Increased Risk for RSV Disease Aged 18 to 59 Years (CID) * Moderna Receives U.S. FDA Approval for RSV Vaccine, mRESVIA, in Adults Aged 18–59 at Increased Risk for RSV Disease (moderna) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Spatiotemporal Association of Coronavirus Disease 2019 Cases and Deaths With Exposure to Wildfire Particulate Matter in 2020 (OFID) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Next ACIP meeting (CDC: ACIP) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Implementation of an online drug-drug interaction screener for the STRIVE ensitrelvir trial for COVID-19 (OFID) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long COVID and ME/CFS with David Tuller (microbeTV) * Reaching out to US house representative * Letters read on TWiV 1228 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
David Tuller returns to TWiV to discuss RFK Jr. and the trashing of American public health, rituximab and ME/CFS, The Sick Times, the Cochrane Mess, a Norwegian Long Covid trial, effort preference and more.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episode * MicrobeTV Discord Server * David Tuller writes at virology blog * CFS, a long tangled tale (virology blog) * The Sick Times * Norwegian Long COVID trial (virology blog) * Cochrane mess (virology blog) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content on TWiV should not be taken as medical advice.
TWiV reviews the administrations dismantling of the committee that studies pandemic potential, firing of CDC vaccine advisory committee and replacing them with unqualified anti-vaxxers, zoonotic and sustained Mpox spread in Nigeria and Cameroon, and breadth of influenza A antibody cross-reactivity.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV 2:39 * NIH terminates pandemic preparedness committee (Science) * RFK Jr. fires all ACIP members (CNN) * RFK Jr. names dubious members of new ACIP (NPR) * Zoonotic and sustained Mpox spread in West Africa (Nature) * Breadth of influenza A antibody cross-reactivity (Nat Micro) * Letters read on TWiV 1227 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Accidental discovery in planetarium show Alan – Project Hail Mary Vincent – How to speak to a vaccine sceptic: research reveals what works
Listener Picks James – Looking at the world through a microscope
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello in horror examine dismantling of public infrastructure for establishing vaccine guidelines, the creation of a autism taskforce by someone disciplined for practicing medicine without a license, the ongoing pertussis, bird flu and measles outbreaks, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, the effective of oseltamivir vs supportive care when one is hospitalized with influenza infection, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines, approval of another anti-RSV monoclonal antibody for treatment in infants, immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, results from the phase 3 randomized clinical trial of pemivibart, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how artery disease impacts SARS-CoV-2 infection outcomes, contacting your federal government representative to stop the assault on science and biomedical research and the recent public health programs that have been unfunded.
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Links for this episode * Vaccine Opponent Hired by RFK Jr. Scours Official Records for Link to Autism (Wall Street Journal) * Correcting our record (Salon) * You are FIRED! Kennedy removes all ACIP members, eyes replacement (CIDRAP) * UPI Investigates: The vaccine conflict…..investigative reporting? (UPI) * RFK Jr.: HHS Moves to Restore Public Trust in Vaccines…to avoid conflicts UGHHHH! (Wall Street Journal) * GREAT Vaccine advisory panel (Great Barrington Declaration) * National Vaccine Information Center (Wikipedia: National Vaccine Information Center) * Nonprofit organization 501(c) (Wikipedia) * Kennedy Announces Eight New Members of C.D.C. Vaccine Advisory Panel (NY Times) * Whooping cough deaths! (Kentucky. Gov) * Kentucky announces two pertussis deaths in infants this year (CIDRAP) * H5 bird flu: current situation (CDC: Avian Influenza) * Stability of influenza viruses in the milk of cows and sheep (medRxiv) * Wastewater for measles (WasterWater Scan) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Canada’s Ontario province reports death of child from measles (Reuters) * Measles outbreaks continue with risk of holidays causing surge (gov.UK) * Measles (WHO) * Measles vaccine recommendations from NYP (jpg) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Oseltamivir Treatment vs Supportive Care for Seasonal Influenza Requiring Hospitalization (JAMA) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Approval for Merck’s ENFLONSIA™ (clesrovimab-cfor) for Prevention of Respiratory Syncytial Virus (RSV) Lower Respiratory Tract Disease in Infants Born During or Entering Their First RSV Season (Merck) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * COVID-19 vaccine for 6 months, 12 years (CDC: childhood vaccination) * COVID-19 vaccine for65 years and older (CDC: Adult vaccination) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long-term outcomes of patients with pre-existing coronary artery disease after SARS-CoV-2 infection (eBioMedicine) * Reaching out to US house representative * Trump Budget Eliminates Funding for Crucial Global Vaccination Programs(NY Times) * Letters read on TWiV 1226 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews the administration’s call for fools gold-standard science, NIH may publish in-house, avian influenza viruses in birds in China, and Omicron pathogenicity and immune responses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Fool’s Gold Standard Science (Nature) * NIH may publish in-house (Stat News) * Diversity of H9N2 in China (Nat Micro) * Omicron and immunity (Cell Rep) * Letters read on TWiV 1225 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Kathy – mSphere virus species names standardization Rich – Real Tides & Currents Graph HD Alan – Invasive termites spreading from privately owned boats Vincent – Entomologist Answers Insect Questions
Listener Picks Gerry – Citations Needed podcast 221: Anti-science mugging Joyrell – Mayday: Air Disaster Favorite one, two, three, for Vincent
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello in dismay examine the MAHA-Make America Health Again-report and its inclusion of fictious studies or “Creative literature degree Medical Science writing”, RFK Jr contradicted by the CDC for COVID-19 vaccine recommendations for children, reduction in MMR vaccine coverage, the ongoing bird flu and measles outbreaks, how the General Accounting Office instructed HHS to fix deficiencies in infectious disease testing before the next pandemic, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines approval of Moderna’s mNEXSPIKE vaccine for fall 2025, childhood immunization recommendations for COVID-19 vaccines, where to find PEMGARDA, results from the phase 3 randomized clinical trial of pemivibart, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, the identification of an association between FOXP4 and long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
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Links for this episode * The MAHA report (The White House) * White House Health Report Included Fake Citations (NY Times) * C.D.C. Contradicts Kennedy and Keeps Advice That Children May Get Covid Shots (NY TImes) * CDC revises recommendation for COVID vaccines in kids (CIDRAP) * Exclusive: CDC Expert resigns from COVID vaccines advisory role (Reuters) * Trends in County-Level MMR Vaccination Coverage in Children in the United States (JAMA Network) * U.S. Cancels Contract With Moderna to Develop Bird Flu Vaccine (NY Times) * Canada Wants to Kill 400 Ostriches. Kennedy and Dr. Oz Want to Save Them. (NY Times) * Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service) * H5 bird flu: current situation (CDC: Avian Influenza) * Bird flu (CDC: Avian Influenza) * H5N1 avian flu strikes another Arizona layer farm (CIDRAP) * Bird flu outbreak kills 95% of Hickman’s Arizona chickens, closes West Valley farms (AZCentral) * Wastewater for measles (WasterWater Scan) * Additional Denver Resident Tests Positive forMeasles (Denver: The Mile High City) * Health officials alert public of potential measles exposure at Denver International Airport and nearby hotel (Colorado: Department of public health and environment) * Colorado announces another measles case linked to Turkish Airlines flight (CIDRAP) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Measles vaccine recommendations from NYP (jpg) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Public Health Preparedness: HHS Needs a Coordinated National Approach for Diagnostic Testing for Pandemic Threats (GAO: US Government Accountability Office) * GAO to HHS: Fix ‘persistent deficiencies’ in infectious-disease testing before next pandemic (CIDRAP) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * mNEXSPIKE is now approved and coming this fall (mNEXSPIKE) * FDA approval for mNEXSPIKE (moderna) * COVID-19 vaccine for 6 months, 12 years (CDC: childhood vaccination) * COVID-19 vaccine for65 years and older (CDC: Adult vaccination) * ACIP Shared Clinical Decision-Making Recommendations (CDC: Advisory Committee on Immunization Practices(ACIP)) * Safety and Efficacy of Pemivibart, a Long-Acting Monoclonal Antibody, for Prevention of Symptomatic COVID-19 (CID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Genome-wide association study of long COVID (Nature Genetics) * Reaching out to US house representative * Letters read on TWiV 1224 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews RFK Jr.”s MAGA report with non-existent literature citations, a new fungus that could further devastate North American bats, surveillance of avian influenza viruses through bird guano in remote regions, and the receptor for HKU5 coronaviruses is ACE2 from Pipistrellus abramus bats.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Bad citations in MAGA report (Med Exp) * Another fungus for North American bats (NY Times) * Surveillance of avian influenza through bird guano (Nat Commun) * ACE2 from Pipistrellus bats is receptor for HKU5 coronaviruses (Nat Commun) * Letters read on TWiV 1223 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – New mutation found in orange cats Kathy – Middle schooler’s STEM project leads to a bacterium with antibiotic activity and to an anti-cancer compound Vincent – Elon Musk’s Legacy Is Disease, Starvation and Death
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses vaccination trends, the changes COVID-19 vaccine recommendations for children and pregnant women, easing of vaccination exemptions in Texas, the ongoing measles outbreak globally before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines and concern as confirmed diagnosis of COVID-19 rise here and in China, different mechanisms by which to reduce transmission of respiratory pathogens, the May 22 VRBPAC COVID-19 vaccine meeting, where to find PEMGARDA, prolonged steroid and antibiotic therapies, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how spike protein may alter mast cells and the immune response and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Vaccination trends (CDC: Respiratory Illnesses) * Weekly COVID-19 Vaccination Dashboard (CDC: COVIDVaxView) * RFK Jr ends coronavirus shot recommendation for healthy children and pregnant women (Washington Post) * Characteristics of Children Ages 1–17 Who Died of COVID-19 in 2020–2022 in the United States (American Academy of Pediatrics) * RFK Jr.’s War on Children (Paul Offit: Beyond the Noise) * AAP analyzes pediatric COVID-19 hospitalizations from 2020-’24 (American Academy of Pediatrics) * COVID-19–Associated Hospitalizations among Children and Adults — COVID-NET (CDC: National Center for Immunizations and Respiratory Diseases) * COVID-19–Associated Hospitalizations among Children and Adults — COVID-NET (CDC: National Center for Immunizations and Respiratory Diseases) * Long COVID in Children (CDC: NCHS) * Long COVID Prevalence and Associated Activity Limitation in US Children (JAMA Pediatrics) * The C.D.C. Now Says Healthy Kids Don’t Need Covid Shots. Is That True? (NY Times) * U.S. Will No Longer Recommend Covid Shots for Children and Pregnant Women (NY TImes) * Gregg Abbott (AP News) * US school-entry vaccination rates fall as exemptions keep rising (AP News) * Whooping cough cases are rising again in the US (AP News) * Amid measles outbreak, Texas is poised to make vaccine exemptions for kids easier (AP News) * Cardiac Events in Adults Hospitalized for Respiratory Syncytial Virus vs COVID-19 or Influenza (JAMA Network Open) * USDA reported H5N1 bird flu detection in wild birds (CDC: Avian Influenza) * USDA reported H5N1 in poultry (CDC: Avian Influenza) * HPAI Confirmed Cases in Livestock (USDA Animal and Plant Health Inspections Service) * H5 bird flu: current situation (CDC: Avian Influenza) * Bird flu (CDC: Avian Influenza) * Measles cases and outbreaks (CDC Rubeola) * Weekly measles and rubella monitoring (Government of Canada) * Measles (WHO) * Measles vaccine recommendations from NYP (jpg) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Respiratory syncytial virus: an under-recognized healthcare-associated infection (Infection Control & Hospital Epidemiology) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (biRxiV) * New Covid variant NB.1.8.1 detected at US airports amid rise in cases * U.S. reports cases of new COVID variant NB.1.8.1 behind surge in China (CBS News) * WHO TAG-VE Risk Evaluation for SARS-CoV-2 Variant Under Monitoring: NB.1.8.1 (WHO) * New COVID variant NB.1.8.1 detected at US airports amid rise in cases (The Economic Times: News) * Infection Control Guidance: SARS-CoV-2 (CDC: COVID-19) * Isolating the burden of transmission-based precautions for COVID-19 (Infection Control & Hospital Epidemiology) * A pilot study of coughing into the shirt to disrupt respiratory pathogen transmission (International Journal of Emergency Medicine) * Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants (JID) * FDA panel is split on updates to COVID shots as questions loom for fall vaccinations(AP News) * COVID-19 Vaccines (2025-2026 Formula) for Use in the United States Beginning in Fall 2025(FDA) * Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Clinical effectiveness of oral antiviral treatment for non-hospitalized high-risk patients with COVID-19 during Omicron JN.1 subvariant wave(Pneumonia) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Patients (CID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19 (Thorax) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade (Journal of Virology) * Reaching out to US house representative * Letters read on TWiV 1222 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews cuts in National Science Foundation budgets, cuts to Harvard University grants, judge blocks ban on Harvard enrolling international students, DOGE ordered cuts of NIH grants, endemic coronavirus infection induces Fc receptor binding antibodies to SARS-CoV-2, and inherited IFNAR1 deficiency causing adverse reactions to measles and yellow fever infectious vaccines.
Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * NSF funding cut to lowest level (NY Times) * 1,000 grants cut at Harvard University (Nature) * Administration ban on international students at Harvard blocked (CNN) * DOGE killed NIH grants (Nature) * Endemic coronavirus infection induces FcR binding antibodies to SARS-CoV-2 (J Virol) * IFNAR1 deficiency and severe reaction to measles and yellow fever vaccines (J Exp Med) * Letters read on TWiV 1221 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Contact lenses that give people infrared vision — even with their eyes shut (one, two) Alan – Autocrats are afraid of you – see the graphic, especially. Vincent – How One Company Secretly Poisoned The Planet
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello debate the changes in FDA vaccine approval policy especially how it is applied to COVID-19 vaccines and restricts vaccine availability/usage and Novavax’s vaccine, mpox on surfaces and in the air, “bird flu”, the ongoing measles outbreak globally before Dr. Griffin reviews recent statistics on RSV, benefits of vaccination for infants, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, the high number of childhood deaths during this “flu” season, the May 22 VRBPAC COVID-19 vaccine meeting, where to find PEMGARDA, prolonged steroid and antibiotic therapies, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, cognitive impairment in long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * FDA to issue new vaccine approval guidance amid questions over coronavirus shots (Washington Post) * FDA vaccine committee meeting(Reuters) * Evidence-based approach to COVID-19 vaccination (NEJM) * FDA CBER townhall: new COVID019 vaccination approval mechanism (YouTube) * FDA poised to restrict access to COVID vaccines, our own Dr. Griffin is cited! (NY Times) * Novavax approval letter (FDA) * We giveth and taketh away: Novavax approved but restricted use (AP News) * FDA approves Novavax COVID vaccine with stricter new conditions (NY Times) * History behind public health falsehoods– vaccine and autism (NPR) * Making vaccines less accessible-RFK Jr making MAHA! (PBS News Hour) * Kenneday says DO NOT to take medical advice from him, the HHS secretary…hummmm (NY Times) * Staying up to date with COVID-19 vaccines (CDC: COVID-19) * How science lost America’s trust and surrendered health policy to skeptics (WSJ) * HHS stops recommendation of COVID-19 shots for children and pregnant women (Reuters) * No more routine COVID-19 vaccines for children and pregnant women (WSJ) * House to investigate Pfizer for allegedly delaying COVID-19 vaccines (Reuters) * Statement on the antigen composition of COVID-19 vaccines (WHO) * WHO advisers say current strains OK for COVID vaccine production (CIDRAP) * We can’t remain indifferent to suffering: Catholic Church now champions HPV vaccination (DailyNation) * Air and surface sampling for mpox in UK (Eurosurveillance) * Researchers report mpox DNA, live virus on surfaces and in air from patients’ rooms(CIDRAP) * USDA reported H5N1 bird flu detection in wild birds (CDC: Avian Influenza) * USDA reported H5N1 in poultry (CDC: Avian Influenza) * HPAI Confirmed Cases in Livestock(USDA Animal and Plant Health Inspections Service) * H5 bird flu: current situation (CDC: Avian Influenza) * Bird flu (CDC: Avian Influenza) * Measles cases and outbreaks (CDC Rubeola) * Measles and rubella weekly monitoring report: (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola) * Measles vaccine (CDC Measles (Rubeola) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) * COVID-19 vaccine VRBPAC May 22 (FDA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * The clinical impact of prolonged steroid therapy in severe COVID-19 patients (BMC Pulmonary Medicine) * Anticoagulation guidelines (hematology.org) * Antibiotic Treatment in Patients Hospitalized for Nonsevere COVID-19 (JAMA Network Open) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Self-reported health, neuropsychological tests and biomarkers in fully recovered COVID-19 patients vs patients with post-COVID cognitivesymptoms (PLoS One) * Vortioxetine for Cognitive Impairment in Major Depressive Disorder During Post-COVID Syndrome (Journal of Clincial Psychiatrist) Reaching out to US house representative * Letters read on TWiV 1220 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews pause in the use of Chikungunya vaccine, HHS to stop recommending COVID shots for pregnant women and children, molecular basis for shifted receptor recognition by an encephalitic alphavirus, and evolution of koala retrovirus transcriptional silencing in wild koalas.
Hosts: Vincent Racaniello, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * Pause in use of Ixchiq (FDA) * Change in COVID vaccine recommendations (STAT) * Basis for receptor shift in encephalitic alphavirus (Cell) * Transcriptional silencing of koala retrovirus (Cell) * Letters read on TWiV 1219 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Rich – What’s that stuff in your bellybutton? Science has the answer. Vincent – New study reveals our skin’s own bacteria can help protect us from the bad effects of sunlight
Listener Pick Rona – My Italian secret: the forgotten heroes and Italy and the Holocaust Foundation, Inc.
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello wail about the attack on science within the US, cancellation of CDC’s committee on infectious diseases, mpox in Sierra Leone, “bird flu” in cats, the ongoing measles outbreak globally, before Dr. Griffin reviews recent statistics on RSV, benefits of vaccination for infants, influenza and SARS-CoV-2 infections the WasterwaterScan dashboard, the high number of childhood deaths during this “flu” season, the May 22 VRBPAC COVID-19 vaccine meeting, where to find PEMGARDA, benefit of remedesivir, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, weight and distinct symptoms of long COVID and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Shut down federal advisory committee on infection prevention…..Make America Healthy Again! (CIDRAP) * Mpox in Sierra Leone (CIDRAP) * H5 Bird Flu: Current Situation (CDC: Avian Influenza (Bird Flu) ) * Spike in avian flu cases in cats : spillover into humans? (CIDRAP) * Measles cases and outbreaks (CDC Rubeola) * Measles 800 in Texas…. (Texas Health and Human Services) * Measles outbreak in North Dakota prompts local health officials to quarantine unvaccinated schoolchildren (CNN) * 2025 Measles outbreak guidance (New Mexico Health) * Measles and rubella weekly monitoring report: (Government of Canada) * The Mennonites in a Texas community where measles is spreading (AP News) * Trust the government? Seriously! West Texans, Mennonites at center of measles outbreak choose medical freedom over vaccine mandates (AP News) * Measles vaccine recommendations from NYP (jpg) * Deporting Measles! (AP News) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * CDC reports 216 child deaths this flu season (AP News) * Weekly surveillance report: clift notes (CDC FluView) * New York sees highest flu-related pediatric deaths ever recorded in a season (Times Union) * Phase 3 Safety and Efficacy Study of Baloxavir Marboxil in Children Less Than 1 Year Old With Suspected or Confirmed Influenza (The Pediatric Infectious Disease Journal) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Interim Evaluation of Respiratory Syncytial Virus Hospitalization Rates Among Infants and Young Children After Introduction of Respiratory Syncytial Virus Prevention Products (CDC: MMWR) * US infant mortality dropped in 2024: RSV vaccine? (AP News) * Infant Mortality Dashboard (CDC: National Center for Health Statistics) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Wastewater Measures of SARS-CoV-2 Accurately Predict Frequency of Symptomatic Infections in the Community (JID) * Origin of SARS-CoV-2 * The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2 (Cell) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * COVID-19 infection history as a risk factor for early pregnancy loss (BMC Medicine) * New recommendations seek treatments for post-Lyme disease condition (CIDRAP) * Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine in Adults ≥50 YearsA Randomized Clinical Trial (JAMA) * Combo flu-COVID vaccine shows good immune response, safety in older adults (CIDRAP) * US FDA advisers to discuss COVID-19 vaccine recommendations on May 22 (Reuters) * Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) * COVID-19 vaccine VRBPAC May 22 (FDA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Remdesivir associated with reduced mortality in hospitalized COVID-19 patients (BMC Infectious Diseases) * Real-world evidence shows remdesivir tied to less death in hospitalized COVID patients (CIDRAP) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Excess weight is associated withneurological and neuropsychiatric symptoms in post-COVID-19 condition (PLoS One) * Identification of soluble biomarkers that associate with distinct manifestations of long COVID (Nature Immunology) * Reaching out to US house representative * Letters read on TWiV 1218 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews new CBER chief at FDA, ending of Gates Foundation in 2045, gain of function executive order, origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2, and single dose Sudan virus replicon vaccine protects guinea pigs from disease.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Prasad replaces Marks at FDA (US News) * Gates Foundation ends 2025 (Gates Foundation) * Gain of function Executive Order (White House) * DURC policy (HHS) * Origins of bat viruses ancestral to SARS-CoV and SARS-CoV-2 (Cell) * Sudan virus replicon vaccine (Nat Comm) * Letters read on TWiV 1217 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Rich – Andor Season 2 Alan – Sequencing Mendel’s pea plant traits, and a good Science news article on the work Vincent –2023 summer warmth unparalleled over the past 2,000 years
Listener Pick Brian – Virology Capabilities Test (VCT): A Multimodal Virology Q&A Benchmark
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello bemoan the attack on science within the US, salt water controls for vaccines, return to 1938 technology for flu vaccines, mRNA vaccines as “bioweapons”, rise in pertussis, benefits of the shingles vaccine and reduced dementia occurrence, and growing measles outbreak globally before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, the May 22 VRBPAC COVID-19 vaccine, meeting, where to find PEMGARDA, return to antibiotic treatment for respiratory viral diseases, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Saline placebo control testing for new vaccines….not good chemistry! (Washington Post) * 1940s innovation: HHS, NIH Launch Next-Generation Universal Vaccine Platform for Pandemic-Prone Viruses(US Department of Health and Human Services) * WHAT! Minnesota Bill Against Vaccines Promotes Disinformation (Medscape Medical News) ) * Guns= fine….mRNA =mRNA Bioweapons Prohibition Act; mRNA injections and products designated as weapons of mass destruction, and mRNA injections and products prohibited. (Minnesota Legislature) * Bioweapons of massive destruction mNRA not bombs or drones….but mRNA! (Minnesota Legislature) * 2024 Provisional pertussis surveillance report (CDC) * Pertussis cases by year 1922-2023 (CDC: Whooping cough (pertussis)) * Deaths by pertussis: 6 children under a year old (CDC) * Pertussis (WHO) * Symptoms of pertussis (CDC Whooping Cough (Pertussis) * With whooping cough cases on the rise, a doctor explains how to protect yourself and others (CNN) * Live zoster vaccination and cardiovascular outcomes (European Heath Journal) * Shingles vaccine recipients see lower cardiac event risk (CIDRAP) * H5 Bird Flu: Current Situation (CDC: Avian Influenza Bird flu) * Measles cases and outbreaks (CDC Rubeola) * Measles 800 in Texas…. (Texas Health and Human Services) * 2025 Measles outbreak guidance (New Mexico Health) * Measles and rubella weekly monitoring report: (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * CDC reports 216 child deaths this flu season (AP News) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Impact of Nirsevimab on RSV and Non-RSV Severe Respiratory Infections in Hospitalized Infants (Influenza and other respiratory viruses) * Hospital admissions of respiratory infections in infants plunge with nirsevimab RSV antibody(CIDRAP) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Early effectiveness of the BNT162b2 KP.2 vaccine against COVID-19 in the US Veterans Affairs Healthcare System (Nature Commications) * Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) * COVID-19 vaccine VRBPAC May 22 (FDA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Time to antiviral treatment in mild–moderate COVID-19 in the emergency department(Internal and Emergency Medicine) * Delays in COVID antiviral receipt raised risk of poor outcomes after ED visits by 18%, data suggest(CIDRAP) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Virus = Bacteria ? National Trends in Antibiotic Prescribing for Adults Hospitalized With Coronavirus Disease 2019 and Other Viral Respiratory Infections (OFID) * Steroids, dexamethasone at the right time (OFD) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Short and long-term trajectories of the post COVID-19 condition (BMJ Infectious Diseases) * Prevalence of Persistent Cardiovascular and Pulmonary Abnormalities on PET/MRI and DECT Imaging in Long COVID Patients (Journal of Nuclear Medicine) * Long-COVID patients show signs of inflammation on PET/ MRI scans(CIDRAP) * Reaching out to US house representative * Letters read on TWiV 1216 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
From the 2024 International Hepatitis B virus meeting in Chicago IL, Rich Condit speaks with Thomas Tu about his experiences as a both a HepB scientist and patient.
Host: Rich Condit Guest: Thomas Tu
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Links for this episode * Support science education at MicrobeTV * Hepatitis B Foundation * Tu Laboratory * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews universal vaccine initiative at NIAID, shut down of the Integrated Research Facility at Ft. Detrick, modeling the reemergence of infectious diseases as vaccination rates drop, and bacterial outer membrane vesicles bound to bacteriophages modulate neutrophil responses to bacterial infection.
Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Paul has Measles (YouTube, virology blog) * Universal vaccine project (NIAID, CIDRAP) * Measles update (US, Texas) * Integrated Research Lab closed (Telegraph) * Modeling reemergence of infectious diseases (JAMA) * Outer membrane vesicles attached to phage (Front Cell Inf Micro) * Pf phage review (Front Immunol) * Letters read on TWiV 1215 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Alan – A Paradise Built in Hell, by Rebecca Solnit (and here’s my review of it) Jolene – Virology course student communication projects, Spring 2025 Vincent –Vaccine Education Center
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello bewail the attack on science within the US and withdrawal from the global health communities, association between the shingles vaccine and reduced dementia occurrence, ending of Uganda’s ebola outbreak, undermining effective responses to human bird flu infections, growing measles outbreak in the US and dire predictions of the return of vaccine preventable diseases including polio if vaccination rates continue to decline, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the WasterwaterScan dashboard, how HHS is undermining the Novavax COVID-19 vaccine, if Paxlovid reduces stroke, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions and contacting your federal government representative to stop the assault on science and biomedical research.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Lab animal RIFFing (NY Times) * Herpes zoster vaccination and dementia occurrence(JAMA) * The recombinant shingles vaccine is associated with lower risk of dementia (Nature Medicine) * Uganda declares end to latest ebola outbreak (Reuters) * Enhancing the response to avian influenza in the US and globally (LANCET: Regional Health-Americas) * H5 Bird Flu: Current Situation (CDC: Avian Influenza Bird flu) * Measles Update — United States, January 1–April 17, 2025 (CDC: MMWR) * Measles in Europe……..but greater in the US (CIDRAP) * Measles – Annual Epidemiological Report for 2024 (ECDC: European Center for Disease Prevention and Control) * Measles (ECDC: European Center for Disease Prevention and Control) * Measles cases and outbreaks (CDC Rubeola) * Measles 800 in Texas…. (Texas Health and Human Services) * 2025 Measles outbreak guidance (New Mexico Health) * On the precipice of disaster’: Measles may be endemic in 25 years if vaccine uptake stays low, model predicts (CIDRAP) * Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US (JAMA) * Measles vaccine recommendations from NYP (jpg) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * 200 children die from flu (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Health secretary RFK Jr. declares certain vaccines have ‘never worked,’ flummoxing scientists…..what certain vaccines?(STAT News) * More FDA uncertainty roils full approval for Novavax COVID vaccine (CIDRAP) * FDA Punts on Major Covid-19 Vaccine Decision After Ouster of Top Official (WSJ) * U.S. health officials inject new uncertainty into approval process for Covid boosters (STAT News) * Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Into the Unknown: Practical Remdesivir Restriction in the Era of Widespread SARS-CoV-2 Seropositivity (CID) * Tocilizumab and IVIG experience during the service follow-up in patients with severe COVID-19 pneumonia(Rev Insti MedTrop Sao Paulo) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection(JAMA) Reaching out to US house representative * Letters read on TWiV 1214 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
From the 2024 International Hepatitis B virus meeting in Chicago IL, Rich Condit speaks with Chari Cohen about her work as President of the Hepatitis B Foundation.
Host: Rich Condit Guest: Chari Cohen
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Hepatitis B Foundation * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews new committee of experts to counter vaccine misinformation, resignation of NSF Director, dependence of immune response to rabies virus on the gut microbiome, and a nucleosome switch primes hepatitis B virus infection.
Hosts: Vincent Racaniello, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Committee of experts to counter vaccine misinformation (Science) * NSF Director resigns (Science) * Dependence of vaccine immune response on gut microbiome (Cell Host Microbe) * Nucleosome switch primes HepB replication (Cell) * Letters read on TWiV 1212 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Wild chimpanzees filmed by scientists bonding over alcoholic fruit Rich – Malcolm Gladwell Revisionist History “The Joe Rogan Intervention” Vincent –Measles Misinformation Is on the Rise — and Americans Are Hearing It, Survey Finds
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello deplore the US’s withdrawal from the global health community for pandemic preparedness i.e. the universal avian flu vaccine, and undermining the use of routine childhood vaccinations for pertussis and measles, RFK’s autism registry, yellow fever outbreak in Colombia and world immunization week after discussing the squirrel as the reservoir host for mpox, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the WasterwaterScan dashboard, how immunity elicited by the RSV vaccine wanes in 3 years, if Paxlovid reduces stroke, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, if vaccination impacts long COVID and if long COVID were to become epidemic.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * The American Public’s Disengagement With Highly Pathogenic Avian Influenza (HPAI): Considerations for Vaccination and Dietary Changes(American Public Health Association) * New agreement geared toward universal avian flu vaccine (CIDRAP) * Cambridge’s DIOSynVax and Singapore’s ACM Biolabs to advance pandemic-ready universal bird flu vaccine with international support (GlobeNewswire) * Bird flu continues to spread among live poultry markets after shut down order (CRAIN’S New York Business) * Fire-footed rope squirrels (Funisciurus pyrropus) are a reservoir host of monkeypox virus (Orthopoxvirus monkeypox)(Research Square) * It is a squirrel! An animal source of mpox emerges(Nature) * Whooping cough spikes, especially among unvaccinated teens (NBC News) * A February flu surge has arrived (NCB News) * Pertussis Cases by Year (1922-2022)(CDC: Whooping cough (pertussis))) * ‘Fighting to breathe’: Whooping cough surges as vaccination rate falters (NBC News) * CDC cancels measles help for Texas schools amid staff layoffs (HealthDay) * Measles cases and outbreaks (CDC Rubeola) * Measles in Texas…. (Texas Health and Human Services) * Measles vaccine recommendations from NYP (jpg) * 2025 Measles outbreak guidance (New Mexico Health) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * RFK Jr.’s autism registry plan (Axios) * RFK Jr’s autism study collecting Americans’ private medical records (Guardian) * The public’s views on measles outbreaks and misinformation (KFF) * Colombia National Emergency: yellow fever cases (Gov.Co) * World Immunization Week: polio eradiation?(GPEI) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * 200 children die from flu (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Trial shows waning efficacy of RSV vaccine across 3 seasons in older adults(CIDRAP) * Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) (LANCET: Respiratory Medicine) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Long-term stroke and mortality risk reduction associated with acute-phase paxlovid use in mild-to-moderate COVID-19(Journal of Medical Virology) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * The effect of COVID-19 vaccination on the risk of persistent post–COVID-19 condition (JID) * ORCHESTRA Delphi consensus: diagnostic and therapeutic management of Post-COVID-19 condition in vulnerable populations (CMI Clinical Microbiology and Infection) * Political ideology and trust in scientists in the USA(Nature Human Behavior) * Leading long COVID researcher fears it could become a national epidemic (Spectrum News NY1) * Center for post COVID care (Mt. Sinai) Reaching out to US house representative * Letters read on TWiV 1212 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
From the 2024 International Hepatitis B virus meeting in Chicago IL, Rich Condit speaks with Stephan Urban about his career working on HBV and HDV, and his philanthropy.
Host: Rich Condit Guest: Stephan Urban
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Hepatitis delta: recent advances (Hepatology) * Bulevirtide for HBV and HDV (Lancet Inf Dis) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV discusses the rising autism rate among children, RFK Jr.’s claim that autism ‘destroys lives’, receptor binding specificity of a bovine H5N1 influenza virus, and improved dengue subunit vaccine modified to form E protein dimers.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Rising autism rate among children (MMWR) * RFK Jr. claims autism ‘destroys lives‘ (NY Times) * Receptor binding specificity of bovine H5N1 virus (Nature) * Bovine H5N1 binds poorly to human receptors (Nature) * AJ Eisfeld et al reply (Nature) * Mootant influenza H5N1 virus (TWiV 1131) * Improved dengue 2 subunit vaccine (J Virol) * Letters read on TWiV 1211 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Scientists detect signature of life on a distant planet, study suggests Rich – Hanlon’s Razor Alan – Baby colossal squid filmed in deep ocean Vincent –How the United States became a science superpower — and how quickly it could crumble
Listener Pick John – Revisionist History: The RFK Jr. Problem
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello rue about the continuation of the gutting of the American public health infrastructure, the continuing measles outbreak, an unreported outbreak of deadly E.coli human infections, meningococcal disease before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, ACIP recommended changes in guidelines for the RSV and COVID-19 vaccines, reactogenicity differences between Novavax and Pfizer COVID-19 vaccines, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, effects of long COVID in children and adolescents and a list of ongoing clinical trials for long COVID treatment.
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Links for this episode * Making America Healthy Again-purging of administrators at HHS (Politico) * Making America Healthy Again-purging of data (Politico) * Deep cuts of the federal government (NY Times) * Cutting NIH, CDC and HHS promotes chronic disease research(Washington Post) * Political ideology and trust in scientists in the USA(Nature Human Behavior) * US political conservatives have deep, unbudging suspicion of science, survey suggests(CIDRAP) * A deadly E. coli outbreak hit 15 states, but the FDA chose not to publicize it(NBC News) * Invasive meningococcal disease – Kingdom of Saudi Arabia(WHO) * The essential guide to understanding the differences between hajj and umrah (Marhabahaji) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Measles booster? (Washington Post) * How to stop an outbreak…….fire the experts (Washington Post) * Measles cases and outbreaks (CDC Rubeola) * Measles 159 in Texas…. (Texas Health and Human Services) * 2025 Measles outbreak guidance (New Mexico Health) * Measles and rubella weekly monitoring (Government of Canada) * Measles vaccine recommendations from NYP (jpg) * NAFMA: North American Free Measles agreement…..(NY Times) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Doctors’ talk measles (YouTube) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * 200 children die from flu (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * ACIP votes to expand recommendation for Pfizer’sRSV vaccine Abrysvo® to include adults aged 50 to 59 at increased risk of disease (Pfizer) * Respiratory syncytial virus and incidence of cardiovascular events: a nationwide self-controlled case series analysis (JACC Journals) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Comorbidities associated with different degrees of severity in children and young people hospitalized with acute COVID-19 (Pediatric Infectious Disease Journal) * SHIELD-Utah study shows Novavax’s COVID-19 vaccine induces lower reactogenicity symptoms compared to mRNA (Novavax) * Interim clinical considerations for use of COVID-19 vaccines in the United States (CDC Vaccines & Immunizations) * Novavax says its COVID vaccine produces fewer, milder reactions than Pfizer version(CIDRAP) * US CDC advisers discuss narrower use of COVID-19 vaccines (Reuters) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusions center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Kidney Function following COVID-19 in children and adolescents(JAMA Network Open) * Cardiovascular post-acute sequelae of SARS-CoV-2 in children and adolescents: cohort study using electronic health records(Nature Communications) * Great barrington declaration (gbdeclaration.org) * Clinical trials: * Effectiveness of transcranial direct current in patients with persistent COVID-19 with headaches and chronic pain. * Home-based Brain Stimulation Treatment for Post-acute Sequelae of COVID-19 (PASC) * Acupuncture for post COVID-19 Condition (Long COVID) neuropsychiatric symptoms * Pain relief with integrative medicine (prime)?: feasibility of acupuncture for long COVID * Electro-acupuncture for long COVID neuropsychiatric symptoms * Randomised study to investigate the effectiveness of acupuncture for the relief of long COIVD-19 related fatigue (ACU-COVID) * Vagus stimulation in female long COVID patients.(Vagus) * Stellate ganglion block with lidocaine for the treatment of COVID-19-induced parosmia (Stella) * Therapeutic updates on long COVID: Where things stand 5 years later (ID Society) * Reaching out to US house representative * Letters read on TWiV 1210 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews RFK Jr’s odd comments on ‘single antigen’ vaccines and his September deadline for understanding why autism has increased, dire wolf does not come back from the dead, oral norovirus vaccine tablet that induces mucosal immunity in older adults, and identification of broadly neutralizing human monoclonal antibodies against norovirus.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2025 * RFK Jr. and Novavax (MSN) * September deadline to understand autism rise (Reuters) * Dire wolf not resurrected (Science) * Oral norovirus vaccine tablet (Sci Transl Med) * Broadly neutralizing norovirus monoclonal antibodies (Sci Transl Med) * Letters read on TWiV 1209 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – New experiment updates classic experiment on how life on Earth started Kathy – APOD ISS meets Venus, Sign up for NASA ISS alerts, GoISS Watch Alan – Mason bees could replace honeybees as crop pollinators Vincent – Mystery of medieval manuscripts revealed by ancient DNA
Listener Pick Sonrisa – GOT’EM Good!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello mourn the demise of vaccination against childhood diseases when discussing the continuing measles outbreak and the rise of pertussis, the first human case of H5N1 in Mexico, and human metapneumovirus before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, if antiviral therapy prevents long COVID and how long COVID may affect brain volume.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * A natural experiment on the effect of herpes zoster vaccination on dementia (Nature) * Taking a shot at dementia (microbeTV: TWiV) * RFK Jr. visits Texas after second child dies of measles amid outbreak (Washington Post) * Kennedy Attends Funeral of Texas Girl Who Died of Measles(NY Times) * ‘Most effective way’ to prevent measles is vaccination, RFK Jr. says, in most direct remarks yet (STAT News) * Fort Bliss…..Fort measles: Beaumont Army hospital confirms measles case at Fort Bliss(KTSM News) * Measles cases and outbreaks (CDC Rubeola) * Measles 159 in Texas…. (Texas Health and Human Services) * Measles vaccine recommendations from NYP (jpg) * 2025 Measles outbreak guidance (New Mexico Health) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Doctors’ talk measles (YouTube) * Measles (CDC: Measles Rubeola) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) * Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) * Deaths following vaccination: what does the evidence show (Vaccine) * Two infants die of whooping cough in Louisiana (CNN) * Clinical features of pertussis (CDC: Whooping cough Pertussis) * Pertussis vaccination recommendations (CDC: Whooping cough Pertussis) * Diphtheria vaccination (CDC: Diphtheria) * Mexico’s first human case of H5N1 (Reuters) * Human metapneumovirus seasonality and co-circulation with respiratory syncytial virus — United States, 2014–2024 (CDC: MMWR) * Influenza: Wastewater scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Human source SARS-CoV-2 aerosol transmission to remote sentinel hamsters (OFID) * Interim clinical considerations for use of COVID-19 vaccines in the United States (CDC Vaccines & Immunizations) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Cost-effectiveness analysis of nirmatrelvir/ritonavir for high-risk individuals with COVID-19….does this mean use the big button calculator? (OFID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA (PAX LC): (LANCET: Infectious Diseases) * Quantitative brain volume differences between COVID-19 patients and non-COVID-19 volunteers (NeuroImage) * Donepezil for fatigue and psychological symptoms in post–covid-19 condition (JAMA Network Open) * Letters read on TWiV 1208 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV notes the passing of Klaus Conzelmann, then reviews reverse-zoonoses of 2009 H1N1 pandemic influenza A viruses and evolution in United States swine, and reduction in dementia incidence in recipients of Zostavax.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2025 * Reverse zoonoses of 2009 H1N1 in US swine (PLoS Path) * Zostavax reduces dementia (Nature) * Letters read on TWiV 1207 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Rich – Certain Roller Coasters May Help Small Kidney Stones Pass Alan – Analog and Asimov’s science fiction magazines Vincent – Science Under Threat in the United States: How scientists and institutions should respond
Listener Pick Charles – Why Techdirt Is Now A Democracy Blog (Whether We Like It Or Not)
In his weekly clinical update, Dr. Griffin and Vincent Racaniello lament about the continuing measles outbreak, whether or not the measles outbreak was predicted, the FACTS about vaccination, high pathogenic influenza, H5N1 contaminated raw pet food, children’s deaths, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules and the efficacy of Moderna’s seasonal mRNA vaccine, societal burden of COVID-19 and influenza, the FDA missed deadline for approving Novovax COVID vaccine, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, and Canada’s long COVID dashboard.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * CDC buried a measles forecast that stressed the need for vaccinations….TRANSPARENCY? (Politico) * Measles cases and outbreaks (CDC Rubeola) * Measles 159 in Texas…. (Texas Health and Human Services) * 2025 Measles outbreak guidance (New Mexico Health) * Measles and rubella weekly monitoring report (Government of Canada) * Enhanced epidemiological summary Measles in Ontario (Public Health Ontario) * Measles and rubella weekly monitoring report (Government of Canada) * Enhanced epidemiological summary Measles in Ontario (Public Health Ontario) * Measles exposures in Ontario (Public Health Ontario) * Measles vaccine recommendations from NYP (jpg) * Get the FACTS about measles (NY State Department of Health) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Raw cat food tests positive for H5N1 (CIDRAP) * Influenza: Waste water scan for 11 pathogens WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Early impact of RSV vaccination in older adults in England (Lancet) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Evaluating the effectiveness of 2024-2025 seasonal mRNA-1273 vaccination against covid-19-associated hospitalizations and medically attended covid-19 among adults aged ≥ 18 years in the united states(medRxiv) * Current Moderna vaccine 53% effective against COVID hospitalization?(CIDRAP) * Preliminary estimates of COVID-19 burden for 2024-2025 (CDC COVID-19) * Estimated range of annual burden of flu in the US from 2010 – 2024 (CDC-flu burden) * US FDA missed the deadline for decision on Novavax’s COVID-19 vaccine (Reuters) * Interim clinical considerations for use of COVID-19 vaccines in the United States (CDC Vaccines & Immunizations) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Metformin alleviates inflammatory response and severity rate of COVID-19 infection in elderly individuals(Scientific Reports) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Cost-effectiveness analysis of nirmatrelvir/ritonavir for high-risk individuals with COVID-19….does this mean use the big button calculator? (OFID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Reinfection with SARS-CoV-2 in the omicron era is associated with increased risk of post-acute sequelae of SARS-CoV-2 infection: a recover-EHR cohort study(medRxiv) * CAN-PCC RecMap, your one-stop shop for recommendations about Post COVID-19 Condition (Long COVID) (Canadian Guidelines for post COVID-19 condition) * Letters read on TWiV 1206 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews liver damage caused by over use of vitamin A in Texas, vitamin A does not change clinical course of measles in high income country, NIH cuts COVID-19 research, US ends vaccine funds for poor countries, anti-vaxxer hired to study vaccines and autism, new DURC policy, Jamaican fruit bat competence for filoviruses, and human outbreaks of Oropouche virus reassortant in Brazil.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2025 * Vitamin A liver disease in Texas (NY Times) * Vitamin A doesn’t help measles in high-income countries (Pediat Inf Dis) * NIH cancels COVID grants (Science) * US ends vaccine funds for poor countries (NY Times) * Anti-vaxxer to study vaccines and autism (Sci Based Med) * DURC rules revised (USG and NIH guidance) * Filoviruses and Jamaican fruit bats (Nat Comm) * Oropouche outbreaks in Brazil (Nat Med) * Woolly mice (NPR) * Letters read on TWiV 1205 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Math of March Madness Brackets Kathy – Wood frogsicles #1 and #2 Alan – Rare glimpse of baby polar bears emerging from dens Vincent – Hikaru Utada Would Rather Play CERN Than Coachella
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello rue about the continuing measles outbreak, the FACTS about vaccination, irresponsibility of promoting vitamin A therapy “lifelong liver damage or vaccinaton!”, high pathogenic influenza and egg importation before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules and if vaccination affects long COVID, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions, how to track long symptoms using a wearable device and how these data will never be used with the closing of governmental long COVID programs and offices.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Measles cases and outbreaks (CDC Rubeola) * Measles 159 in Texas…. (Texas Health and Human Services) * 2025 Measles outbreak guidance (New Mexico Health) * 10 in Ohio and 23 in Kansas…..oh my! (US News) * Measles data (Kansas: Department of Health and Enivornment) * Health director urges parents to ensure children are vaccinated against measles (Ohio: Department of Health) * Get the FACTS about measles (NY State Department of Health) * New York Governor Kathy Hochul sounds alarm for measles vaccine amid 4 confirmed cases (abc News) * Get the FACTS about measles (NY State Department of Health) * Long-term dynamics of measles virus–specific neutralizing antibodies in children vaccinated before 12 months of age (CID) * Measles vaccine (CDC Measles (Rubeola)) * Clinical Overview of Measles (CDC Rubeola) * Red Book: 2024–2027 Report of the Committee on Infectious Diseases (33rd Edition)(Redbook) * Vitamin A in Children Hospitalized for Measles in a High-income Country (Pediatric Infectious Disease Journal) * No vaccination necessary…….instead take vitamin A and develop liver damage….(NY Times) * Measles vaccine recommendations from NYP (jpg) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Influenza of avian origin confirmed in a sheep in Yorkshire (UK government) * UK reports H5N1 in a sheep on poultry-outbreak farm(CIDRAP) * Don’t send money….send EGGS! (Reuters) * Are your eggs domestic or Brazilian? (Reuters) * USDA to invest 100M in bird flu projects…..(Reuters) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Flu in US continues to decline but still packs a punch (CIDRAP) * Weekly surveillance report: clift notes (CDC FluView) * Respiratory virus activity levels (CDC Respiratory Illnesses) * FDA-CDC-DOD: 2025-2026 influenza vaccine composition (FDA) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Weekly US influenza surveillance report (CDC FluView) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Lower levels of household transmission of sars-cov-2 omicron variant of concern vs wild type: an interplay between transmissibility and immune status (JID) * Does COVID-19 vaccination reduce the risk and duration of post COVID-19 condition?(European Centre for Disease Prevention and Control) * COVID-19 vaccination reduces risk of ‘long COVID’ in adults (European Centre for Disease Prevention and Control) * Vaccination cuts the risk of long COVID 27%, review suggests (CIDRAP) * Interim clinical considerations for use of covid-19 vaccines in the United States (CDC: Vaccines and immunizations) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * The effect of nirmatrelvir-ritonavir on short- and long-term adverse outcomes from covid-19 among patients with kidney disease (ofid) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Effect of pulmonary rehabilitation for patients with long COVID-19(Therapeutic Advances in Respiratory Disease) * Wearable data reveals distinct characteristics of individuals with persistent symptoms after a SARS-CoV-2 infection(npj digital medicine) * Long Covid office ‘will be closing,’ Trump administration announces(Politico) * Commencing the reduction of the federal bureaucracy(White House) Musk said no one has died since aid was cut. That isn’t true.(NY Times) * Letters read on TWiV 1204 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV explains why RFK Jr.’s proposal to let H5N1 infections in birds ‘rip’ is a bad idea, phase 1/2 trial of combined influenza/COVID mRNA vaccines, and how your first influenza virus exposure shapes the B cell response to influenza vaccination 50 years later.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Subscribe (free): Apple Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support science education at MicrobeTV * ASV 2025 * RFK Jr. says let H5N1 rip through flocks (NY Times) * Combined flu/COVID mRNA vaccine (Nat Comm) * Rare syndrome after COVID vaccination (NY Times, medRxiv) * Imprinting lasts 50 years (Immunity) * Imprinting protects against H5N1 and H7N9 (Science) * Letters read on TWiV 1203 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Node-Focal Plane Image Competition Rich – Periodic cooking of eggs Vincent – The use of placebo controls in clinical trials
Listener Picks Anne – Everything is Tuberculosis by John Green
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello rue about the unknowns of Sudan disease and new cases of paralytic polio, discuss the growing measles outbreak, exposure of newborns to measles, the FACTS about vaccination, high pathogenic influenza in dairy cows and cats, RFK’s statement “just let the virus rip through the hens” before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, what happens when antiviral therapy is delayed, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions and the relationship between EBV and long COVID.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * New cases of poliomyelitis (GPEI) * Polio in Africa (CIDRAP) * Program for Monitoring Emerging Diseases (PROMED) * ProMED Subscriptions (PROMED) * Measles infected baby and exposes 12 (NY Post) * Measles 159 in Texas…. (Texas Health and Human Services) * 2025 Measles outbreak guidance (New Mexico Health) * Get the FACTS about measles (NY State Department of Health) * Revising US MMR vaccine recommendations amid changing domestic risks (JAMA Network) * Long-term dynamics of measles virus–specific neutralizing antibodies in children vaccinated before 12 months of age (CID) * Newborns exposed to measles in Texas hospital (NBC News) * Newborns exposed in West Texas measles outbreak (CIDRAP) * Measles (CDC Measles (Rubeola)) * Measles vaccine (CDC Measles (Rubeola)) * Presumptive evidence of measles immunity (CDC) * Contraindications and precautions to measles vaccination (CDC) * Measles (CDC Measles (Rubeola)) * Increase in global and domestic measles cases and outbreaks: (CDC:) * The impact of influenza A H5N1 virus infection in dairy cows (Nature: Research Gate) * Payment of indemnity and compensation for highly pathogenic avian Influenza (Federal Register) * FDA or USDA: Kennedy’s alarming prescription for bird flu on poultry farms(NY Times) * Some of NYC’s 500K stray cats could be infected with bird flu(NY Post) * Two NYC cats dead from avian flu, including 8-month-old kitten:(NY Post) * H7N9 avian flu strikes Mississippi broiler farm(CIDRAP) Highly pathogenic avian influenza diagnosed in Mississippi poultry flock (Mississippi Board of Animal Health) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * The burden of all-cause mortality following influenza-associated hospitalizations (CID) * FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) * FDA announces flu strain picks for next season(CIDRAP) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Weekly US influenza surveillance report (CDC FluView) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * COVID-19 antiviral medication use among pregnant and recently pregnant US outpatients (CID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID TGFβ links EBV to multisystem inflammatory syndrome in children(Nature) * Letters read on TWiV 1202 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
Infectious diseases physician and author of ‘Booster Shots’ Adam Ratner joins TWiV to discuss measles, measles vaccination, how to approach anti-vaccine sentiment, and the uncertain future of children’s’ health.
Hosts: Vincent Racaniello, Brianne Barker, and Jolene Ramsey Guest: Adam Ratner
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * Booster Shots by Adam Ratner * The Cutter Incident by Paul Offit * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello bemoan the continued outbreak of Sudan virus and growing number of paralytic polio cases before discussing growing measles outbreak in the US and Europe, the vaccine, an interview with a parent whose child died of measles infection, adverse effects of vaccination and how parents do not think they have accurate information about “bird flu” before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, what happens when antiviral therapy is delayed, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions and the benefits of antiviral therapies on post acute SARS-Cov-2 infection sequelae.
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Links for this episode * Sudan virus disease(WHO) * New cases of poliomyelitis (GPEI) * Measles 159 in Texas…. (Texas Health and Human Services) * 2025 Measles outbreak guidance (New Mexico Health) * First cases of measles in Oklahoma (Oklahoma) * Measles case on Long Island (CBS News) * Public health confirms measles case in Los Angeles County (County of Los Angeles Public Health) * Measles exposure (Department of public health: City of Philadelphia) * Where US measles outbreaks are spreading (New York Times) * Statement from the chief public health officer of Canada on the increase in measles cases and the risk to people in Canada(Health Canada) * Measles and rubella monthly report (ecdc) * Measles on the rise again in Europe (EurekAlert) * Measles: symptoms, spread & SSPE | Doctors Talk | Children’s Hospital of Philadelphia (YouTube) * Measles (CDC Measles (Rubeola)) * Adverse events associated with childhood vaccines: evidence bearing on causality (NLM: NCBI) * Measles vaccination: know the facts? (Infectious Diseases Society of America) * Deaths following vaccination: What does the evidence show? (Vaccine) * Facts and myths about measles (LANCET: Infectious Diseases) * His daughter was America’s first measles death in a decade (The Atlantic) * Less than half of parents think they have accurate information about bird flu (EurekAlert) * Many US parents feeluninformed about avian flu risks (CIDRAP) * Trends in respiratory pathogen testing at us children’s hospital(JAMA Network) * Changes in respiratory viral testing before and after the covid-19 pandemic(JAMA Network) * Free COVID-19 test program stops taking orders (Health day) * Human cases of highly pathogenic avian influenza a(h5n1) — California, September–December 2024 (CDC MMWR) * Letters read on TWiV 1198 37:56 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV covers a second death over 150 cases of measles in Texas, utter failure of removal of type 2 poliovirus from OPV, more OPV doses administered in Gaza, second Ebola outbreak in Sudan, vaccine being tested, Trump administration cancels $400 million in grants to Columbia University, bat-infecting merbecovirus that binds human ACE2 and infects human cells, and innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrhea.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Second child dies of measles (NY Times) * Over 150 measles cases in Texas (Texas DSHS) * Utter failure of removal of OPV2 from OPV (Science) * Over 600,000 doses of OPV administered in Gaza (polioeradication) * Second outbreak of Sudan Ebola in Uganda (IAVI) * Columbia grants canceled by administration (NBC News) * Bat merbecovirus also infects human cells via Ace2 (Cell) * Recent virus research, was proper containment used? (NY Times) * Innate immune sensing of rotatvirus leads to diarrhea (Cell Host Microbe) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Kathy – Mice cry out when they urinate, and give mouth to mouth resuscitation Rich – Firefly Aerospace Alan – Strong Museum of Play Vincent – How a PhD student’s lab size affects their chance of future academic success
Listener Picks Larry – James Harrison’s rare blood protected many infants
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin with Vincent Racaniello deliberate the effect of the absence of US foreign aid on the Ebola outbreak in Uganda and death of two children, continued use of nOPV2 in Gaza and the utter failure of type 2 poliovirus removal from the oral poliovirus vaccine, growing measles outbreak in the US including the death of a second child, measles infection parties, the use of fat soluble vitamin A and fish liver oil as anti-viral therapies as well as the history and proven safety of the measles vaccine before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, what happens when antiviral therapy is delayed, provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions, long COVID interventions.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * African region: outbreaks and other emergencies(WHO Bitstream) * US withdrawal……death of 4 year old children from Ebola (CIDRAP) * Science and health writer Apoorva Mandavilli (NY Times) * US foreign aid pullback……death of 4 year old in Uganda (NY Times) * Another Ebola death reported in Kampala (Monitor) * African region: outbreaks and other emergencies(WHO Bitstream) * More than 600,000 doses of nOPV2 in Gaza last week (GPEI) * Utter failure of the global withdrawal of the Sabin oral poliovirus type 2 vaccine 2016 (Science) * Measles 159 in Texas…. (Texas Health and Human Services) * Second child dies in the growing measles outbreak (Washington Post) * 2025 Measles outbreak guidance (New Mexico Health) * Lea county resident tests positive for measles after death (New Mexico Health) * Robert F Kennedy Jr article series (The Guardian) * Kennedy Jr backtracks and says US measles outbreak is now a ‘top priority’ for health department (The Guardian) * RFK Jr. Says Ending Measles Outbreak Is Priority (Wall Street Journal) * RFK Jr. Sparks Anti-Vaxxer Anger: ‘No Different Than Fauci’ (Newsweek) * Amid West Texas measles outbreak, vaccine resistance hardens (Washington Post) * How to protect your children during a measles outbreak (healthychildren.org) * Measles vaccination protects against virus infection and other infections (Science) * MEASLES(WHO) * C.D.C. Sends ‘Disease Detectives’ to Texas for Measles Outbreak(NY Times) * Studies on an attenuated measles-virus vaccine — clinical, virologic and immunologic fffects of vaccine in institutionalized children(NEJM) * Studies on an attenuated measles-virus vaccine — clinical and antigenic effects of vaccine in institutionalized children (NEJM) * Studies on an attenuated measles-virus vaccine — administration of vaccine by several routes (NEJM) * Studies on an attenuated measles-virus vaccine — clinical, antigenic and prophylactic effects of vaccine in institutionalized and home-dwelling children(NEJM) * Studies on an attenuated measles-virus vaccine — clinical, antigenic and prophylactic effects of vaccine in institutionalized children(NEJM) * Studies on an attenuated measles-virus vaccine — clinical, antigenic and prophylactic effects of vaccine in home-dwelling children (NEJM) * Studies on an attenuated measles-virus vaccine — general summary and evaluation of the results of vaccination(NEJM) * Cooperative measles vaccine field trial (Pediatrics) * A collaborative study of measles vaccines in five united states communities (American Journal of Public Health) * A field trial of inactivated measles virus vaccine in young school children(JAMA Network) * Prevention of natural and experimental measles with the vaccine(JAMA Network) * A field trial in young school children(JAMA Network) * Measles vaccination before the measles-mumps-rubella vaccine (American Journal of Public Health) * The status of measles vaccines (Journal of the National Medical Association) * Measles, mumps, and rubella (mmr) vaccination: what everyone should know (CDC Vaccines & Immunizations) * Clinical review memo- measles, mumps, rubella (FDA) * History of the measles vaccine (WHO) * Vitamin A and the measles (Yahoo! News) * As measles spreads, Kennedy embraces remedies like cod liver oil (NY Times) * Parents are holding ‘measles parties’ in the U.S., alarming healthexperts(Global News) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Weekly US influenza surveillance report (CDC FluView) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Interim estimates of 2024–2025 covid-19 vaccine effectiveness among adults aged ≥18 years — vision and ivy networks, September 2024–January 2025 (CDC MMWR) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Effect of early and delayed treatment with remdesivir on mortality in patients hospitalized with COVID-19 (OFID) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID * Letters read on TWiV 1198 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews passing of Ann Palmenberg, deadly illness in western Congo, US disruption of mpox and ebolavirus programs, first measles death in Texas outbreak, flu vaccine selection meeting postponed, US withdraws from polio, malaria, HIV programs and more, clade 2.3.4.4b H5N1 viruses have a long HA stalk, and systems vaccinology to identify predictors of durable antibody response to multiple vaccines in humans.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Ann Palmenberg dies (Cress) * Ann at Chumakov Symposium (YouTube) * Unknown illness in Congo (NY Times) * Bad news about mpox outbreak (NPR) * US interrupts Ebola prevention program (NPR) * First measles death in Texas (Texas Trib) * Flu vaccine selection meeting canceled (NY Times) * US ends funding for polio, HIV, malaria and more (NY Times) * Clade 2.3.4.4b H5N1 neuraminidase has a long stalk (mBio) * Predictors of durable antibody responses to vaccines (Nat Immunol) * Review of adjuvants (Vaccinol Methods Vacc Res) * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – Video of the Northern Lights from Space Rich – Vaccination for Sudan Ebola virus disease Alan – Specialized moth wing scales give it 3-D camouflage (news and paper) Vincent – WHO Recommendations for Influenza Vaccine Composition for the 2025-2026 Northern Hemisphere Influenza Season
Listener Picks Gerry – Eukaryotic Transcription Anne – The science of the solar system
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello lament about the downfall of public health from “postponement” of the advisory committee on immunization practices and the FDA VRBPAC influenza strain selection meetings to how the communication pause prevents public notice of NIH study section meetings, and withdrawal of CDC promotions for the ‘flu vaccine’ before discussing the end of Ebola outbreak in Uganda, funding from Saudi Arabia for polio eradication, the continuing and growing measles outbreak in the US including misinformation from the Secretary of HHS, highly pathogenic avian flu and its economic effect, ie the cost of eggs before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, long COVID interventions and FDA approval of adjuvanted Novovax COVID vaccine.
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Links for this episode * Phantom ACIP (CDC) * Postponement of ACIP…..hummmm (STATNews) * Influenza Strain selection VRBPAC cancelled (Reuters) * How NIH funded research is impacted by government communication pause (NY Times) * Can be reviewed but still no money (STATNews) * Final push to end Ebola in Uganda (WHO Uganda) * Saudi Arabia sponsors polio eradication effort (GPEI)) * $500 million from Saudi Arabia to immunize 370 million children against polio (CIDRAP) * Measles 124 in Texas…. (Texas Health and Human Services) * A Texas child who was not vaccinated has died of measles(AP News) * The Measles book-(Apple Books) * Measles vaccination protects against virus infection and other infections (Science) * Measles deadliest sequelae (MEDPAGE TODAY) * Measles cases and outbreaks (CDC Measles) * Unvaccinated Child Dies of Measles in Texas Outbreak(NY Times) * Texas child is first reported US measles death in a decade as outbreak hits more than 130 (Reuters) * Trump’s cabinet meeting: Kennedy Shocker “Not unusual”……..seriously! (YouTube) * First measles death reported in Texas as Kennedy downplays the outbreak (NBC News) * Measles cliff notes: symptoms timeline (Substackdn) * Annual state immunization report (Texas Health and Human Services) * Measles imported into Kentucky…….no tariffs? (Commonwealth of Kentucky) * Egg shortage affect flu shots? (MEDPAGE TODAY) * Which Came First, the Chicken Slaughter or the Egg Shortage(Wall Street Journal) * Avian Influenza in Birds: Causes and How It Spreads (CDC Avian Influenza) * Agriculture Secretary Brooke Rollins: My Plan to Lower Egg Prices (Wall Street Journal) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Weekly US influenza surveillance report (CDC FluView) * US respiratory virus activity (CDC Respiratory Illnesses) * Trump administration yanks CDC flu vaccine campaign(NPR) * RSV-Network (CDC Respiratory Syncytial virus Infection) * New wild to mild campaign drives key message to tame flu and reset expectations * (CDC Influenza) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Effectiveness of the original monovalent messenger RNA Coronavirus Disease 2019 (COVID-19) vaccination series against hospitalization for COVID-19–Associated venous thromboembolism (JID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Infusion center (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Demographic variation in US outpatient hydroxychloroquine and ivermectin use during the COVID-19 pandemic (HealthAffairs) * Paxlovid update (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Alleviation of COVID-19 symptoms and reduction in healthcare utilization among high-risk patients treated With nirmatrelvir/ritonavir (NMV/R) (CID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Interventions for Long COVID: A Narrative Review (Journal of General Internal Medicine) * COVID-19 vaccination and odds of post–COVID-19 condition symptoms in children aged 5 to 17 Years (JAMA Network) * Novavax COVID-19 vaccine, adjuvanted (FDA) * Letters read on TWiV 1196 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
The entire TWiV team comes together to pay tribute to Dickson Despommier, then reviews antibodies to H5N1 virus in veterinarians working with dairy cattle, Elisabeth Bik donates prize money for data integrity analyses, measles outbreak in Texas, and use of an alternative genetic code by human microbiome phages.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, Angela Mingarelli, and Jolene Ramsey
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Livestream tribute to Dickson (Office Hours) * Dickson’s Wikipedia page * Dickson’s obituary (NY Times) * Dickson websites: trichinella.org, thelivingriver.org, fordhamopolis.com, despommierphotoart.com * Alan’s tribute to Dickson (alandove.com) * H5N1 seroprevalence (MMWR) * Elisabeth Bik donates prize money (Science) * Measles outbreak in Texas (Texas DSHS) * Human microbiome phages use alternative genetic code (Nat Comm) * Letters (mostly not) read on TWiV 1195 – all about Dickson * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Rare spotting of humpback anglerfish “diablo negro” (Melanocetus johnsonii) in Tenerife, Canary Islands. First time ever observed alive! Brianne – Moonwalking with Einstein inspired by reading NY Times article about Recent memory champ Kathy – Witness History 9 minute podcasts Rich – APOD: Perijove 11: Passing Jupiter Alan – Ecological succession on abandoned farmland Jolene – Parasitic Diseases Lectures and first 27 episodes of This Week in Parasitism Vincent – The New City
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello reminiscence about Dickson before discussing discharging Ebola patients, another announcement of emergency measures to control polio spread and the third nOPV2 vaccination campaign in Gaza in less than 6 months, the measles outbreak in the US, vaccination campaign for chickens against high pathogenic avian flu before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * In memory of Dickson (NY Times) * All Ebola patients discharged in Uganda (DG Alerts) * Uganda discharges Ebola patients (WHO Uganda) * Emergency measures to stop polio…..isn’t this the same plan as last year? (GPEI)) * A third nOPV2 campaign…..but I thought OPV stops transmission (Reuters) * Worst outbreak of measles in 30 years for Texas….go big or go home! (AP News) * Measles 58 in Texas…. (Texas Health and Human Services) * High pathogenic avain influenza virus infection of indoor domestic cats (CDC MMWR) * Avian influenza in dairy cattle in Arizona (AZEIN) * Third avian flu spillover! (CIDRAP) * No vaccine hesitancy in chickens…..vaccinate all! (Science) * Zoetis to supply conditionally licensed avian influenza H5N1 vaccine for chickens (Zoetis) * High path avian influenza in mammals (USDA: Animal and plant health inspection service) * How to vaccinate your chicken (WikiHow) * Vaccine failure due to poor administration.(the poultry site) * Human cases of H5N1 in US rise to 4 (CBS News) * Canada’s buying vaccine as US rats become infected (CIDRP) * Canada purchases avian influenza vaccine for those at high risk (Canada Public Health) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * How the communications pause endangered us about influenza (AP News) * Most intense flu season in 15 years (AP News) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Weekly US influenza surveillance report (CDC FluView) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * COVID-19 case fatality rate and infection fatality rate from 2020 to 2023 (Journal of Infection and public health) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid update (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in healthy volunteers (eBioMedicine) * Ensitrelvir for the Treatment of Nonhospitalized Adults with COVID-19 (CID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Letters read on TWiV 1194 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV reviews a facility accident that killed monkeys, new bird blu genotype found in Nevada dairy cattle, Argentina plans to leave WHO, yellow fever on the rise, dynamics of HPV infections in women, and Epstein-Barr virus protein targets B cell receptor for degradation.
Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Accident kills monkeys at SC research supply facility (Science) * D1.1 Genotype in Dairy Cattle in Nevada (APHIS) * Argentina to leave WHO (CIDRAP) * Yellow fever on the rise (CIDRAP) * HPV dynamics in women (PLoS Biol) * EBV protein degrades B cell receptor (PNAS) * Letters read on TWiV 1193 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences (one, two) Alan – A little adventure game Vincent – The Staggering Success of Vaccines
Listener Picks John – Percy Lavon Julian Debi – Don’t Look Up
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss confirmation of Robert F Kennedy as HHS sectary, mpox, Ebola, how the American people support vaccine development and administration, the measles outbreak in the US-Texas, Georgia and influenza: the number of human infections, high avian flu in mammals, house cats and dairy cows before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how long COVID varies between children and adults and if viral infection reduces telomere length in sperm.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Confirmation of RFK, Jr as HHS sect (NY Times) * Did you know mpox in NY?….(Reuters) * Mpox in sex workers in the Congo and in NY (CIDRAP) * 9 confirmed, 265 suspected Ebola cases in Uganda (AP news) * WHAT!? Support vaccines: availability and development. WHAT? (Businesswire) * Measles rising in the unvaccinated. You mean the vaccines does something positive? (ABC News) * Measles in Texas….go big or go home (Texas Health and Human Services) * Vaccination Conscientious exemptions in Texas (Texas Health and Human Services) * 2, 6, 14 measles hospitalizations in Texas (CNN) * Decreases in childhood vaccinations SchoolVaxView(CDC) * 2 when 24 cases of measles in two weeks (Texas Health and Human Services) * Measles in small town Texas (NY Times) * Measles in the US Texas, Georgia, Rhode Island, New York, New Mexico: * Elimination of measles (JID) * Influenza taxonomy (NCBI) * H5N9 in commercial duck farm, California (American Animal Hospital Association) * Second type of bird flu circulating in ducks (Scientific Amercia) * Variant H1N2 flu in Iowa (CIDRAP) * All types of influenza (CDC Influenza) * Bird flu in the zoos: Bronx and Queens (Gothamist) * High path avian influenza in mammals (USDA: Animal and plant health inspection service) * Bird flu in house cats…..I tawt I taw a puddy tat (KFF Health News) * New strain of influenza in dairy cows (AP News) * Influenza: Waste water scan for 11 pathogens (WastewaterSCan) * How the communications pause endangered us about influenza (AP News) * Most intense flu season in 15 years (AP News)US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * Weekly US influenza surveillance report (CDC FluView) * RSV-Network (CDC Respiratory Syncytial virus Infection) * 10 year surveillance of RSV hospitalization in adults(JID) * Seasonality of RSV: 2017-2023(CDC: MMWR) * What doctors wish patients know about RSV (AMA) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid update (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Proportion of Long COVID incidence in adults and children (CID) * SARS-CoV-2 infection effects sperm telomere length (Journal of Assisted Reproduction and Genetics) * Pediatric gastrointestinal tract outcomes during the postacute phase of COVID-19c]\ (JAMA Network) * Letters read on TWiV 1192 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews freezes and unfreezes of US government grants, how prior COVID-19 vaccination prevents over-reaction of the innate immune response during infections, and how bat genomes illuminate adaptations to viral tolerance and disease resistance.
Hosts: Vincent Racaniello and Alan Dove Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * NIH freezes (ScienceAdviser) * Is your research on Trump’s hit list? (ScienceInsider) * Prior COVID-19 vaccination tames innate responses (Sci Transl Med) * Bat genomes illuminate viral tolerance and disease resistance (Nature) * Letters read on TWiV 1191 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Alan – NOAA Space Weather Prediction Center dashboards Vincent – He created a hummingbird paradise in his backyard
Listener Picks Christiane –Contact your members of Congress about the Pause in Federal Grant Funding Charles – What’s trending in the world of pseudoscience
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information and aid mechanisms such as the return of MMWR, the largest tuberculosis outbreak in the US ever, lack of USAID in fighting Marburg and Ebola outbreaks in Africa, discussing if avian influenza virus is airborne, how eggs are effected and the emergence of second spillover into dairy cattle, how the difference between nOPV2 and Sabin OPV2 is a minor reduction in the association of vaccine associated paralytic poliomyelitis before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, an update of Paxlovid administration provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how children may be affected by long COVID and if SARS-CoV-2 and other inflammatory syndromes increase the risk of Alzheimer’s disease.
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Links for this episode * The return of MMWR (CDC) * Largest tuberculosis outbreak ever in the US (Kansas Department of Health and Environment) * Marburg virus outbreak in Tanzania (Doctors without borders) * No USAID, Ebola outbreak in Uganda spreads (CBS News) * WHO accelerates efforts to Ebola response in Uganda (WHO: Uganda) * Global partners enable access to vaccine and treatment for Ebola outbreak in Uganda (WHO) * Ventilation and respiratory viruses (CDC National Institute for Occupational safety and health) * Is bird flu flying through the air…..is the virus literally airborne? (NY Times) * Is bird flu like measles (American Journal of Epidemiology) * Indoor safety guideline (Herokuapp) * Dairy herds in Nevada have influenza! (CIDRAP) * Do your eggs have H5N1? (NY Times) * New genotye D1.1 of avian flu in dairy cattle(USDA Animal and Plant Health Inspection Service) * Second spillover of avian flu into dairy cattle….does this story sound familiar? (CIDRAP) * Impact of using nOPV2 in mass vaccination campaigns? (JID) * Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * As flu increases so do deaths in kids (CIDRAP) * People most impacted by respiratory viruses (CDC) * Co-infection with SARS-CoV-2 and influenza A/B (BMC Infectious Diseases) * Oseltamivir reduces 30-Day mortality in older adults with Influenza (OFID) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Drug interaction checker (University of Liverpool) * Paxlovid update (Pfizer) * Infectious Disease Society guidelines for treatment and management (ID Society) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long COVID Recovery Program with Zara Dureno, BA, MOT * Long COVID pevalence and associated activity limitation in US children * (JAMA Pediatrics) * Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection (Nature Medicine) * Letters read on TWiV 1190 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV notes the HHS communication pause, and describes research showing that rotavirus viroporin activity is necessary for intracellular calcium signals that contribute to viral pathogenesis, and control of human orthrflavivirus vaccine challenge by T cells in the absence of neutralizing antibodies.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Rotavirus viroporin activity, calcium waves, and pathogenesis (Sci Adv) * T cells control human orthoflavivirus challenge (Nat Micro) * Letters read on TWiV 1189 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Brianne – The Perfect Cacio e Pepe Recipe, According to Science (primary article here) Kathy – Dragonflies Loop-the-Loop Alan – My Beloved Monster, by Caleb Carr Vincent – Why Did the FDA Ban Red Dye #3
Listener Picks Anne –Japan’s 65-Foot Towering Snow Walls
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information, the Marburg and Ebola outbreaks in Africa, the largest tuberculosis outbreak in the US ever, the politicization of polio vaccine campaigns in Pakistan, effect of high pathogenic influenza in animals and on the economy before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, trials and devices to relieve some neurological complications of long COVID and the ramifications of long COVID in children, healthcare workers and adults.
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Links for this episode * No morbidity and mortality in the US this week? (NPR) * More support for Marburg outbreak in Tanzania (Reliefweb) * Tanzania confirming second Marburg case (CIDRAP) * Norovirus mRNA vaccine …..hmmmm? (moderna) * What is noronvirus? (modernatx) * Largest tuberculosis outbreak ever in the US (Reuters) * Ebola outbreak in DRC during US:WHO strain (STAT News) * Uganda Ebola outbreak…..1 dead (Reuters) * Polio outside endemic zone due to militants? (Washington Post) * Mpox vaccination initiation in central Africa (CIDRAP) * Preparing rapid response to emerging infectious disease in Africa (PANTHER Health) * Mpox therapeutic study MOSA enrollment begins (Africa CDC) * Halting of US foreign aid for health programs…..not in the US best interests? (NY Times) * No PEPFAR (NY Times) * PEPFAR (US Department of State) * PEPFAR…..still not America first? Really? (CIDRAP) * Resurgence of infections globally may affect US…..what is global health? (NY Times) * Milk testing for H5N1….but I thought raw milk was the only healthy milk? (USDA) * How do you like your $10.99 dozen of eggs? (NY Times) * Farm outbreak of H5N1 (AP News) * US- high pathogenicity avian influenza viruses (World Organization for Animal Health) * H5N9 high pathogenic flu in duck farm California (CIDRAP) * More egg issues (CIDRAP) * Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024 (LANCET Infectious Diseases) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long COVID Recovery Program with Zara Dureno, BA, MOT * The current and future burden of long COVID in the United States (JID) * Transcutaneous vagus nerve stimulation improves Long COVID symptoms in a female cohort (Frontiers in Neurology) * Transcutaneous vagus nerve stimulation trials: https://www.mountsinai.org/clinical-trials/tvns-in-long-covid-19 https://www.centerwatch.com/clinical-trials/listings/NCT06585254/tvns-in-long-covid-19 Devices: https://pulsetto.tech/products/meet-pulsetto?pulsetto_offer_id=57&transaction_id=1024e5a0258b6647e262ba8fec5d62 https://www.dolphinmps.com/product/dolphin-neurostim-professional-single-kit-vagal-stim-kit/ * Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls (Pediatric Research) * Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection(PLoS Medicine) * SARS-COV-2 re-infection and incidence of post-acute sequelae of COVID-19 (PASC) among essential workers in New York (LANCET: Regional Health Americas) * Impact of COVID-19 Pandemic on the incidence and prevalence of postural orthostatic tachycardia syndrome (EHJ-QCCO European Heart Journal-Quality of Care & Clinical Outcomes) * Letters read on TWiV 1188 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, Brianne Barker, and Angela Mingarelli
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * Entry receptor for EV-D68 (Cell Host Microbe) * Anti-herpetic tau preserves neurons in Alzheimers (Cell Rep) * Letters read on TWiV 1187 * Timestamps by Jolene Ramsey. Thanks!
Weekly Picks Angela – Good genes are nice, but joy is better Brianne – Beaker Hair Clip Kathy – Pareidolia explained by street artist David Zinn TEDx talkAlso visit zinnart.com Alan – Screwworm is coming back in the Americas Vincent – Dr. Jay Bhattacharya Was Nice to Someone During a Debate. That Doesn’t Erase the Consequences of His Misinformation
Listener Picks Sarah – The Extremophile Campaign: In Your Home (ECIYH) citizen science
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin and co-host Vincent Racaniello lament about the public changes from withdrawing from the WHO to health and scientific communication pauses by the Trump Administration after a brief discussion of Marburg in Tanzania and mpox in England before reviewing cats and bird flu, the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, and where to go for answers to your long COVID questions.
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Links for this episode * Tanzania confirms Marburg virus outbreak (Reuters) * Clade Ib mpox in England (Reuters) * Withdrawing from the World Health Organization (WhiteHouse) * Fees costs behind withdrawing from WHO ….is that what we are suppose to believe? (Sky News) * Sorry to see you go, US? (WHO) * Where are the updates? (CDC Health Alert Network) * Pause in health communications of all kind (Washington Post) * NIH chaos…..streaming to a halt? (STAT News) * Devastation at the NIH, hiring traveling, meetings, communications(Science) * Protect your cat from bird flu (NPR) * No communication and cats with bird flu….does not sound good (CIDRAP) * Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * Baloxavir marboxil for prophylatix against influenza(NEJM) * Comparative effectiveness of baloxavir marboxil and oseltamir treatment for reducint household transmission of influenza (Influenza and other respiratory viruses) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Host-microbe multiomic profiling identifies distinct COVD-19 immune dysregulation in solid organ transplant recipients (Nature Communications) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19 (Signal Transduction and Targeted Therapy) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * The answers: Long COVID * Long COVID Recovery Program with Zara Dureno, BA, MOT * Letters read on TWiV 1186 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene Ramsey. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains Guillain-Barré Syndrome associated with RSV vaccines, outbreaks of metapneumovirus in China and India, editors resign to protest Elsevier’s use of AI in publishing, global distribution and diversity of wild bird associated pathogens, and broadly inhibitory anti-neuraminidase antibody from human memory B cells.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * GBS with RSV vaccine (FDA) * Increase in respiratory infections in China (ECDC) * Elsevier journal editors resign (Retract Watch) * Wild bird associated pathogens (Med) * Broad anti-neuraminidase antibody (Cell Host Micr) * Letters read on TWiV 1185 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Dear Reviewer 2 Rich – National Data Buoy Center Alan – BBC audio program on the World Morse Code Championships Vincent – These are the 20 most-studied bacteria — the majority have been ignored
Listener Picks
Peter – Local graffiti in Sydney Vivian – The Peoples’ Hospital by Dr. Ricardo Nuila
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, if “long COVID” like symptoms occurs after influenza and how long COVID may associate with neurological complicates that control verbal memory.
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Links for this episode * Notable infectious diseases in US (CDC NNDSS) * Get your Tdap: whooping cough case increase (California Department of Public Health) * Resurgence of measles among preschool aged children 1989-1991 (CDC: MMWR) * Adults vulnerable to ‘childhood’ diseases (NY Times) * Pivotal decision that led to a resurgence of polio (NY Times) * Can polio return due to lagging vaccination? (NY Times) * NoroSTAT Data Table (CDC Norovirus) * The discovery of the 27-nm Norwalk virus: an historic perspective (JID) * Why the “Ferrari of viruses” is surging through the northern hemisphere (Science) * Waste water scan for 11 pathogens (WastewaterSCan) * Norovirus at Chipotle, $25million food fine (NY Times) * Chipotle food issues: 2015 settlement with the justice department (Chipotle News) * Purcel anyone? Hand sanitizers increase norovirus risk? (Canadian Medical Association Journal) * Visualization by immune electron microscopy of a 27nm particle associated with acute infectious nonbacterial gastroenteritis (Journal of Virology) * Winter vomiting disease (JID) * ACIP: expanded recommendations for pneumococcal conjugate vaccines(CDC: MMWR) * Presumptive bird flu case in San Francisco (SF. Gov) * Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * Antiviral medications for treatment ofnonsevere influenza(JAMA Network: JAMA Internal Medicine) * Xofluza (GoodRx) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Symptom evolution in individuals with ongoing symptomatic COVID-19 and post COVID-19 syndrome after SARS-CoV-2 vaccination versus influenza vccination (Journal of Infection) Neurological post-COVID syndrome is associated with substantial impairment of verbal short-term and working memory (Scientific Reports) * Letters read on TWiV 1184 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews some of their favorite virology stories from 2024.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * SARS-CoV-2 origins (TWiV Special) * TWiV 1163: Hepadnaviridae in the heartland * TWiV 1117 Pol dances with the RNA that brought it * HPV vaccine success (TWiV 1083, 1151, 1159, 1173) * Monkeypox (TWiV 1095, 1119, 1143, 1145, 1147) * Influenza H5N1 virus (VTWiV 1113, TWiV 1131, TWiV 1173) * Influenza B/Yamagata removed from vaccine (TWiV 1161) * Fiasco of poliomylelitis eradication (TWiV 1091, TWiV 1125, TWiV 1105, TWiV 1151, TWiV 1145, TWiV 1147, TWiV 1161, TWiV 1143) * Protective immunity isn’t just bout antibodies (TWiV 1089, 1105, 1115, 1135, 1165) * Closing the toilet lid doesn’t help (TWiV 1083) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Scientists put vampire bats on treadmills to learn about metabolism Kathy – Says Who?: A Kinder, Funner, Usage Guide for Everyone Who Cares About Words Rich – Mark Rober on PBS Newshour Brief But Spectacular (Wiki; Testing The World’s Smartest Crow) Vincent – How Glenn Gould Broke Classical Music
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how nirmatrelvir-ritonavir/Paxlovid reduces adverse outcomes of COVID in patients with kidney disease, provides information for Columbia University Irving Medical Center’s long COVID treatment center, SARS-CoV-2 infection affects skin conditions including shingles and if long antiviral treatment affects long COVID.
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Links for this episode * Mpox vaccination hesitancy, previous immunisation coverage, and vaccination readiness in the African region (eClincial Medicine) * Global prevalence and correlates of mpox vaccine acceptance and uptake (Communications Medicine) * First case of new mpox variant in France (Reuters) * First “Bird flu” death in US (NY Times) * Emerging threat of H5N1 to human health (NEJM) * Don’t feed your pets raw food (County of Los Angeles Public Health) * Oregon, nationwide raw pet food recall (CIRAP) * Raw cat food avian flu, is this like raw milk? (CIDRAP) * Human metapneumovirus surging in China (The Guardian) * Viral video of viral chaos: human metapneumovirus in Chinese hospital (The Economic Times) * Human metapneumovirus in China (NY Times) * Acute respiratory infections including human metapneumovirus in northern hemisphere (WHO) * Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: clift notes (CDC FluView) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * The effect of nirmatrelvir-ritonavir on short- and long-term adverse outcomes from COVID-19 among patients with kidney disease (OFID) * Paxlovid tied to lower risk of hospital stay, heart problems, death in adults with kidney disease and COVID (CIDRAP) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Chronic urticaria, vitiligo, alopecia areata, and herpes zoster following COVID-19 infection (Journal of Dermatology) * Impact of extended-course oral nirmatrelvir/ritonavir in established Long COVID: * (Communications Medicine) * Letters read on TWiV 1182 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses an outbreak of influenza H5N1 that killed over half of the great cats at a Washington sanctuary, origin and cross-species transmission of bat coronaviruses in China, and the diverse and abundant phages that enter cells via receptors encoded on conjugative plasmids.
Hosts: Vincent Racaniello, Rich Condit, and Jolene Ramsey
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * H5N1 virus kills great cats at Washington sanctuary (CNN) * Macroevolution of bat coronaviruses in China (Nat Comm) * EcoHealth Alliance funding suspended (Science) * Conjugative plasmids support diverse and abundant phages (Nat Comm) * Letters read on TWiV 1181 * Timestamps by Jolene. Thanks!
Weekly Picks Rich – Pareidolia (wiki) Jolene – Pathways to Science database Vincent – Wendy Carlos and Switched-On Bach
Listener Picks Arjan – Gutsick Gibbon’s YouTube channel Alan – 2024 Nobel Prize Lectures in Chemistry
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the recent increase in norovirus outbreaks, human cases of H5N1 avian influenza, before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how effective Molnupiravir is and provides information for Columbia University Irving Medical Center’s long COVID treatment center.
Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Norovirus: Waste water scan for 11 pathogens (WastewaterSCan) * Adolescent with Influenza A H5N1 infection (NEJM) * Highly pathogenic avian Influenza A ( H5N1) virus infections in humans (NEJM) * Emerging threat of H5N1 to human health (NEJM) * US respiratory virus activity (CDC Respiratory Illnesses) * In-hospital outcomes of healthcare-associated Coronavirus Disease 2019 (Omicron) versus healthcare-associated Influenza (CID) * Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * RSV: Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Real clinical effectiveness of Molnupiravir against 30-day mortality (OFID) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center)Post-COVID Condition Risk Factors and Symptom Clusters and Associations with Return to Pre-COVID Health (CID) * Letters read on TWiV 1180 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews RFK Jr’s demand to revoke polio vaccine, Wuhan lab samples do not include close relatives to SARS-CoV-2, using artificial intelligence to discover the RNA virosphere, and biomarkers that discriminate early and late phases of respiratory virus infections from a SARS-CoV-2 human challenge study.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli
Subscribe (free): Apple Podcasts, RSS, email
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Links for this episode * Support science education at MicrobeTV * ASV 2025 * RFK Jr lawyer wants revocation of polio vaccine (CNN) * Wuhan lab has no samples close to SARS-CoV-2 (Nature) * Using AI to discover RNA virosphere (Cell) * SARS-CoV-2 human challenge reveals biomarkers (Nat Comm) * Does this challenge study pass the smell test? (TWiV 863) * Letters read on TWiV 1179 * Timestamps by Jolene. Thanks!
Weekly Picks Angela – Science’s 2024 breakthrough of the year, Lenacapavir “the long shot”. NEJM papers with Lenacapavir trials: one and two. Kathy – Bach Toccatta and Fugue on floor piano Rich – Never Cry Wolf Vincent – Common Raven and American Crow
Listener Pick Jaan – Meute (one, two, three)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin deep dives into the whooping cough epidemic and bird flu in big cats, and in conjunction with your host Vincent Racaniello discusses the recent case of paralytic poliomyelitis in Israel, measles outbreaks and HHS campaign for vaccine safety campaign before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if the COVID mRNA vaccine is effective against symptomatic SARS-CoV-2 infection and hospitalization in children, where to find PEMGARDA, information for Columbia University Irving Medical Center’s long COVID treatment center, how long COVID effects one’s activities, personality and neuropsychiatric symptoms.
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Links for this episode * Highest level of whooping cough cases in a decade (NBC News) * Provisional pertussis surveillance report (CDC) * Polio moves into Israel (Jerusalem Post) * Polio today (GPEI) * Measles- the let’s get real vaccination campaign (CDC) * Measles fact sheet (CDC) * Measles- near you (CDC) * Let’s get real about childhood vaccines (HHS) * The FACTS about childhood vaccines (HHS) * Tigers and cougars dying from bird flu, oh my! (NY Times) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * US respiratory virus activity (CDC Respiratory Illnesses) * Weekly surveillance report: cliff notes (CDC FluView) * Burden of all-cause mortality following Influenza-associated hospitalizations (CID) * Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Initial effectiveness of mRNA-1273 against SARS-CoV-2 infection and hospitalization in young children (OFID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Long COVID and significant long COVID–associated activity limitation among adults * (CDC: MMWR) * 2024 Update of the RECOVER-Adult Long COVID Research Index (JAMA Network) * About 8% of US adults have ever had long COVID, survey finds(CIDRAP) * Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescents (eClinicalMedicine) * Personality and neuropsychiatric symptoms in individuals diagnosed with long COVID(BMC Infectious Diseases)Post-COVID Condition Risk Factors and Symptom Clusters and Associations with Return to Pre-COVID Health (CID) * Letters read on TWiV 1178 38:11 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
At the School for Influenza in Brisbane, TWiV speaks with Kirsty, Erik and Rebecca about their careers and their research.
Host: Vincent Racaniello
Guests: Kirsty Short, Erik Karlsson, and Rebecca Cox
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Links for this episode * Support science education at MicrobeTV * Diabetes, obesity, and COVID-19 severity (Diab Care) * Rice farming and zoonosis in Cambodia (One Health) * Influenza correlates of protection (mBio) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin continues his discussion of whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses how routine childhood immunizations especially that against poliovirus are threatened by Robert F Kennedy Jr and Aaron Siri, the origin of the SAR-CoV-2 virus and retraction of Didier Raoult’s research, then returns to discussing the first case of severe disease following H5N1 infection in humans and the state of California’s “bird flu emergency”, the benefit of the measles vaccine, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how vaccination reduced hospitalization of children between 5-17 years, the ACIP recommendation for the immunocompromised, where to find PEMGARDA, information for Columbia Unversity Irving Medical Center’s long COVID treatment center, long COVID in cancer patients and the physical malaises of long COVID.
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Links for this episode * Mystery disease in DRC kills mostly children (ALJAZEERA) * Malaria—mysterious disease in DRC? (ALJAZEERA) * Mysterious disease in DRC is severe malaria (ALJAZEERA) * Confirmed first severe human H5N1 case (CIDRAP) * California declares bird flu emergency (Reuters) * RFK’s lawyer asks FDA to revoke approval of the polio vaccine (NY Times) * NO WAY! Vaccination promotes survival and health? (LANCET) * 10.6 million cases of measles this year alone! (WHO) * 20% rise in measles…..(NY Times) * No Sars-CoV-2 relatives in Shi Zhengli’s freezers (Nature) * Controversial COVID study that promoted unproven treatment retracted after four-year saga (Nature) * Influenza weekly surveillance report: clift notes (CDC FluView) * Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * US respiratory virus activity (CDC Respiratory Illnesses) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * BNT162b2 XBB Vaccine for COVID-19 Among Children 5-17 Years ofAge (JAMA Network) * ACIP recommendations for those over 65 years and those under 6 months who are immunocompromised (CDC MMWR) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Post-acute sequelae of COVID-19 in cancer patients: Two cohorts in UK and Hong Kong(Cancer Medicine) * Skeletal muscle adaptations and post-exertional malaise in long COVID (Cell: Trends in Endocrinology & Metabolism) * Letters read on TWiV 1176 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the appearance of poliovirus in Europe, mystery disease in DRC, global burden of Chikungunya, viruses of parasitic nematodes that induce antibody responses in vertebrate hosts, and picobirnaviruses, do they infect eukaryotes or prokaryotes?
Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey
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Links for this episode * ASV 2025 * Write your senators about RFK Jr * Support science education at MicrobeTV * Poliovirus in Europe (WHO) * DRC mystery disease (Reuters) * Global burden of chikungunya (BMJ Global Health) * RNA viruses of parasitic nematodes (Nat Micro) * Picobirnaviruses encode bacterial lysins (PNAS) * Prokaryotic ribosome binding site in picobirnavirus genome (Virology) * Letters read on TWiV 1175 * Timestamps by Jolene. Thanks!
Weekly Picks Alan – Sondehub and radiosonde hunting Jolene –Book “10 to 25: The Science of Motivating Young People” By David Yeager Vincent – Dr. Vinay Prasad “Sabotaging RFK Jr’s Confirmation Will Increase Vaccine Hesitancy” & “Doctors Criticizing RFK Jr. Paved the Way for His Ascendancy”
Listener Picks Syl – Foldscope Jennifer – minutiae
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin deep dives into whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses the failure of the poliovirus eradication campaign with virus circulation detected throughout Europe and how we should focus on disease control not virus circulation, then returns to discussing avian influenza in raw milk and the early stoppage of the mpox antiviral Tecovirimat before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, and information for Columbia Unversity Irving Medical Center’s long COVID treatment center.
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Links for this episode * IIs the mysterious disease in the Congo, malaria? (AP News) * State of global health, year-end remarks by WHO director-general (WHO) * Really, progress towards poliomyelitis eradication? (CDC MMWR) * Increases in confirm cases ¹ control of poliomyelitis (WHO) * Polio European Union and United Kingdom, is that 1 global entry? (Science) * Is the WHO the global CDC? polio vaccination guidelines (WHO) * Do you feed your cats raw milk? (Public Health LA county) * Is there avian influenza in the zoo near you? (Maricopa) * Don’t feed your cat raw milk (CIDRAP) * Holy Cow! H5N1 in cows! (microbeTV) * Tecovirimat no improvement in Mpox resolution or pain(NIAID NIH) * Interim results from STOMP study of Tecovirimat (SIGA) * Trial stops enrollment after Tpoxx fails (CIDRAP) * Is Tecovirimat really first-in-class mpox therapy? (Viruses) * Influenza weekly surveillance report: clift notes (CDC FluView) * US respiratory virus activity (CDC Respiratory Illnesses) * Waste water scan for 11 pathogens (WastewaterSCan) * RSV-Network (CDC Respiratory Syncytial virus Infection) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea (Vaccine) * Phase III trial results! Comparative efficacy and safety of COVID-19 (BMC Infectious Diseases) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Stop playing favorites with COVID-19 in healthcare settings (Infection Control & Hospital Epidemiology) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients Hospitalized for COVID-19 (CID) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Letters read on TWiV 1174 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews nominees to head NIH, FDA, and CDC, cervical cancer decline following HPV vaccination, local dengue in Texas, human isolate of H5N1 virus is transmissible and virulent in animal models, and shared mechanisms of immune evasion among animal and bacterial viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey
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Links for this episode * Bhattacharya nominated to head NIH (Science) * Makary nominated to head FDA (Science) * Weldon nominated to head CDC (Chief Healthcare Exec) * Cervical cancer declining following vaccination (JAMA Net) * Local dengue case in Texas (Texas HHS) * H5N1 human isolate transmissible and virulent (Nature) * H5 current situation (CDC) * Global H5N1 cases (Our World in Data) * Conserved immune evasion in animal and bacterial viruses (Cell) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Pale Blue Pod Kathy – PhysicsGirl recent Instagram post, ScienceAdvisor signup free daily sci news distillation, Semi-conducting hydrogels, Bot that can pick up things with a soft touch, “Pigeonbot II”, a drone called LisRaptor, zapping forever chemicals like PFAS with light and here Rich – Vendee Globe Jolene – Center for the Improvement of Mentored Research Experiences Vincent – These two ancient human relatives crossed paths 1.5 million years ago
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center’s long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood.
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Links for this episode * Influenza weekly surveillance report: cliff notes (CDC FluView) * US respiratory virus activity (CDC Respiratory Illnesses) * Influenza vaccines protect against secondary infections in households (JAMA Network) * Benefit of early oseltamivir therapy for influenza A (CID) * RSV-Network (CDC Respiratory Syncytial virus Infection) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Maternal infection of SARS-CoV-2 during 1st and 2nd trimesters newborn telomere shortening (Journal of Translational Medicine) * What is a B1 cell? (Wikipedia) * Pre-COVID and post-COVID vaccination on long COVID (Journal of Infection) * Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies after BNT162b2 Vaccination in Children (The Pediatric Infectious Disease Journal) * Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea (Vaccine) * Phase III trial results! Comparative efficacy and safety of COVID-19 vaccines (BMC Infectious Diseases) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients Hospitalized for COVID-19 (CID) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID(Scientific Reports) * Mitigating the risks of post-acute sequelae of SARS-CoV-2 infection (PASC) with intranasal chlorpheniramine (BMC Infectious Diseases) * Measurement of circulating viral antigens post-SARS-CoV-2 infection (CID) * Letters read on TWiV 1172 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member’s ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Why RFK Jr is not suitable for HHS (YouTube) * Write your Senators to oppose RFK Jr * Support MicrobeTV * ASV 2025 * Susceptibility to infections in asylum seekers (NEJM) * RSV hospitalization in adults (JAMA Net Open) * Ethics failings at French university (Science) * RSV transmission in New Zealand (Nat Commun) * Glycan reactive IgM binds multiple viruses (SciImmunol) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Publication of Updated Human Cell Atlas Rich – Astroscale Alan – E3 ubiquitin ligase game, and an article about its origin Vincent – In the Quantum World, Even Points of View Are Uncertain
Listener Pick Ryan – A Dangerous Moment
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is “adapting” for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the ‘seat belt’ of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving!
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Links for this episode * Influenza weekly surveillance report: cliff notes (CDC FluView) * US respiratory virus activity (CDC Respiratory Illnesses) * RSV-Network (CDC Respiratory Syncytial virus Infection) * In case you missed, US respiratory virus activity (CDC Respiratory Illnesses) * Adaptation of H5N1 to humans…..sequence analysis (Nature) * Favoring human transmission for H5N1 ?(Youtube: medcram) * From 2022: unprecedented bird flu outbreaks sweeping the world…..and we are still talking about it? (Nature) * What children get flu: First child in US infected with H5N1 (CDC Newsroom) * Bird flu detected in raw milk……but RFK at HHS says it is safe? (NBC News) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * If I see no one in my house, household Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission is reduced! (CID) * Updated boosters conferred protection against SARS-CoV-2 infection and emergency visits/hospitalizations during a JN.1 variant wave(CID) * Provisional COVID-19 mortality (CDC National Center for Health Statistics) * Influenza, RSV and COVID-19 vaccine in nursing home residents (CDC MMWR) * Vaccines are the seat belts of public health (TRID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Effectiveness of molnupiravir against 30-day mortality among 74 541 SARS-CoV-2 positive patients (OFID) * Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo(JAMA Network Open) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Remdesivir for treatment of COVID-19 requiring oxygen support (CID) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Neurologic manifestations of long COVID disproportionately affect young and middle-aged Adults (Annals on Neurology) * To review, three score and two months ago, the WHO brought for on this planet, the declaration of SARS-CoV-2/COVID-19…. * How nature began a pandemic (microbeTV) * Bullying within the origin scientific discourse……by those at Rutgers (Science) * Scientific harassment on the rise (Science) * Doxing :The de-identified of the de-identified (Wikipedia) * Harassment survey (Science) * The harm of factless hypotheses (mSphere) * In summary, the era of harm: factless theories (microbeTV) * Stay inside: risk of SARS-CoV-2 transmission in community indoor settings (JID) * Lower levels of household transmission of SARS-CoV-2 VOC Omicron compared to Wild-type: an interplay between transmissibility and immune status (JID) * Long COVID hotline (Columbia : Columbia University Irving Medical Center) * Letters read on TWiV 1170 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research.
Hosts: Vincent Racaniello, Kathy Spindler, and Steph Langel
Guests: Stephanie Gras and Jenna Guthmiller
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Links for this episode * Goldilocks zone of influenza immunity (J Inf Dis) * Broadly neutralizing HA antibodies (Nature) * T cell epitopes needed for influenza vaccines (Clin Transl Immunol) * T cell epitopes conserved in emerging H5N1 viruses (Clin Transl Immunol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald’s before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV’s own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and translational science being conducted to understand long COVID including ongoing clinical trials, development of animal models and how sex may affect outcomes.
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Links for this episode * Micky D’s onions linked to E. colioutbreak….another reason to not eat fast food (CDC) * RFK Jr. series…..does he get anything right? (FactCheck.org) * Salk polio vaccine : a calculated risk? (BMJ) * How to conduct a controlled vaccine trial (American Journal Public Health Nations Health) * Safety and efficacy of BNT162b2 mRNA COVID-19 vaccine (NEJM) * Another Safety and efficacy study: mRNA-1273 SARS-CoV-2 vaccine (NEJM) * …..SERIOUSLY! can’t RFK Jr get it correct? (FactCheck.org) * ‘I’ve Come Home Today’: RFK Jr. (the Defenders Children’s Health Defense News & Views) * Thank God for sensible people: Racaniello and Offit (microbeTV) * RFK Jr. : MAN CAN’T YOU GET ANYTHING RIGHT? (Annenberg Public Policy Center: University of Pennsylvania) * No harm in repeating Vinny! Thank God for sensible people: Racaniello and Offit (microbeTV) * Did America think Trump-Kennedy through? …..really did you think this through? (microbeTV) * Make American Healthy Again? ……I will have fries with that….SUPERSIZED! (Wall Street Journal) * Keep the United States HEALTHY! (Safe Communities Coalition) * Measles in the US (CDC Measles: Rubeola) * The merry-go-around of measles (JID) * It is a measles outbreak! (CDC Measles: Rubeola) * 10.3 million measles infections in 2023….but no vaccine (WHO) * Underutilization of influenza antiviral treatment among children and adolescents (CDC MMWR) * Increase in influenza infection in children…..(CIDRAP) * Influenza weekly surveillance report: clift notes (CDC FluView) * $340 million doses of mpox vaccine ordered for 2025 (Reuters) * Mpox in NYC (JID) * Respiratory virus activity (CDC Respiratory Illnesses) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * N95 Filtering Facepiece Respirator use (JAMA Open Network) * The Risk of SARS-CoV-2 Transmission in Community Indoor Settings (JID) * Lower levels of household transmission of SARS-CoV-2 VOC Omicron compared to Wild-type: an interplay between transmissibility and immune status (JID) * Enhanced placental antibody transfer efficiency with longer interval between maternal RSV vaccination and birth (AJOG: American Journal of Obstetrics and Gynecology) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Perceptions and Barriers to Outpatient Antiviral Therapy for COVID-19 and Influenza as Observed by Infectious Disease Specialists (OFID) * Drug–Drug Interactions with Nirmatrelvir/Ritonavir(Infectious Diseases and Therapy) * Drug interaction checker (University of Liverpool) * Real-world effectiveness of nirmatrelvir-ritonavir and molnupiravir (CMI: Clinical Microbiology and Infection) * Alleviation of COVID-19 Symptoms and Reduction in Healthcare Utilization Among High-Risk Patients Treated With Nirmatrelvir/Ritonavir (CID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Long-COVID Clinical Trials (RECOVER) * Initiating Long Covid RECOVERy (Science Translational Medicine) * Beyond acute SARS-CoV-2 infection in children (Science Translational Medicine) * Long COVID and Osler’s Web: Chronic Fatigue Syndrome (goodreads) * Sex differences in post infection sequalae (Science Translational Medicine) * Symptoms after Lyme disease: What’s past is prologue (Science Translational Medicine) * Animal models of Long COVID (Science Translational Medicine) * Therapies for Long COVID (Science Translational Medicine) * Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution (Science Translational Medicine) * The Long COVID ISSUE (Science Translational Medicine) * Letters read on TWiV 1168 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV Fundraiser * Novel H5N1 in Cambodia (medRxiv) * More cVDVP2 circulation (polioeradication.org) * Infectious parvovirus B19 with proteases (Nat Comm) * B cell receptor enhancement of dengue disease (PLoS Path) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – See How Many Lives Vaccines Have Saved Around the World based on Lancet study Dickson – 2024 Wildlife Photographer of the Year Kathy – 450 Million year old arthropods preserved in fool’s gold. Primary article Pyrite video Vincent – ‘We need to be ready for a new world’: scientists globally react to Trump election win
Listener Picks Jack – Coronavirus vaccine update
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin apprises us about the first case of highly pathogenic influenza in Canda, children dying of influenza infection and novel genetic reassortments of the virus, the Marburg virus outbreak in Rwanda, number of mpox infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how scientific mistrust has affected COVID-19 vaccine administration, resolution of the FDA hold on Novovax’s combination influenza and COVID vaccine, where to find PEMGARDA, how Paxlovid SAVES you money, when to use steroids to treat COVID-19 and how trace amounts of cytokines elicted during SARS-CoV-2 infection negatively impact cardiac function.
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Links for this episode * Bird flu flew into British Columbia Canada (Global News Canada) * H5N1 in British Columbia (CIDRAP) * Highly Pathogenic Avian Influenza flies commercial and domestic (USDA) * Countdown till the end of Marburg outbreak (WHO Rwanda) * First kid’s death due to flu (CIDRAP) * Influenza weekly surveillance report: clift notes (CDC FluView) * H5N1 novel reassortments in migratory birds in China (Emerging Infectious Diseases) * Serologic evidence of recent infection with highly pathogenic avian influenza A (MMWR) * Seriously? 50,000 mpox cases in African outbreak (CIDRAP) * Respiratory virus activity (CDC Respiratory Illnesses) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Science trust: behind COVID 19 vaccine acceptance (Vaccine X) * Vaccine mistrust levels are not budging (Healthday) * FDA clinical hold lifted on Novavax’s combination COVID-flu vaccine(Reuters) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Real-world effectiveness of nirmatrelvir-ritonavir and molnupiravir (CMI: Clinical Microbiology and Infection) * Alleviation of COVID-19 Symptoms and Reduction in Healthcare Utilization Among High-Risk Patients Treated With Nirmatrelvir/Ritonavir (CID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Secondary bacterial infection follows COVID-19 (Nature Communications) * Daniel Griffin’s evidence based medical practices for long COVID (OFID) * Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function (Nature Medicine) * Letters read on TWiV 1166 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate immunity in alveolar macrophages after SARS-CoV-2 infection reduces secondary influenza A virus disease.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV Fundraiser * Diane Griffin passes (Johns Hopkins) * Diane Griffin on TWiV 453 * First H5N1 influenza virus in US pigs (CIDRAP) * IFITM3 controls interspecies influenza virus infection (Nat Comm) * Trained innate immunity by alveolar macrophages (Immunity) * Timestamps by Jolene. Thanks!
Weekly Picks Angela – See a giant ‘ghost particle’ detector and more — October’s best science images Brianne – October 27 APoD: Bat nebula Dickson – Nikon Small World Contest 2024 winners Kathy – AAAS 150th anniversary video, celebrating scientists and Pew’s 2024 annual Trust in Science survey findings Rich – Cats Basically Are a Liquid After All, Study Confirms Alan – HHMI’s Beautiful Biology site Vincent – EcoHealth Alliance Fights Back
Listener Picks Hunter – Don’t stop me now: Queen’s Brian May on saving badgers — and the scientific method Anne – Reasons to be cheerful
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal antibody therapy for prophylaxis, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if and how do severe secondary bacterial infections develop following SARS-CoV-2 infection, and if COVID-19 associates with a risk of autoimmune and autoinflammatory connective tissue disorders.
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Links for this episode * Is the WHO the world’s NIH: endemic pathogens initiative (eBioMedicine) * Another two cases of mpox in Britian (Reuters) * How to stop Marburg virus (Rwanda Biomedical Centre) * Marburg Virus fact sheet (Rwanda Biomedical Centre) * Influenza weekly surveillance report: cliff notes (CDC FluView) * RSV NETwork (CDC RSV) * Respiratory virus activity (CDC Respiratory Illnesses) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Symptom reduction after additional vaccine dose during Omicron (OFID) * IDSA Guideline update for SARS-CoV-2 monoclonal antibody pemivibart pre-exposure prophylaxis (CID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Secondary bacterial infection follows COVID-19 (Nature Communications) * Daniel Griffin’s evidence-based medical practices for long COVID (OFID) * Autoimmune and autoinflammatory connective tissue disorders following COVID-19 (JAMA Dermatology) * Letters read on TWiV 1164 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From the 2024 International Hepatitis B virus meeting in Chicago, TWiV speaks with Mala Maini and John Tavis about their careers, the replication and transmission of HBV, and the HBV Foundation.
Hosts: Vincent Racaniello and Rich Condit
Guests: Mala Maini and John Tavis
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Links for this episode * MicrobeTV Discord Server * Immunobiology and pathogenesis of hepatitis B virus infection (Nat Rev Immunol) * HBV Foundationhttps://www.hepb.org/ * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about “walking pneumonia”, the phase of the polio supplemental immunization campaign in Gaza, mpox circulation, the Marburg virus outbreak in Rwanda, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, if mRNA boosters affect mucosal immunity against SARS-CoV-2 infection, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if antiviral therapy prevents long COVID and viral sequalae in healthy young marines.
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Links for this episode * Mycoplasma pneumoniae infections increasing (CDC) * Polio vaccination campaign restarts (Reuters) * North Gaza polio campaign postponed (Reuters) * 1St clade 1b mpox in UK (GOV.UK) * UK imports mpox (CIDRAP) * Clinical trial of MVA-BN for children (Bavarian-Nordic) * How to stop Marburg virus (Rwanda Biomedical Centre) * Marburg Virus fact sheet (Rwanda Biomedical Centre) * Laboratory confirmed influenza associated hospitalizations 2010-2023 (CDC) * Influenza weekly surveillance report: cliff notes (CDC FluView) * Mucosal nirsevimab levels in breakthrough bronchiolitis (LANCET Infectious Diseases) * RSV NETwork (CDC RSV) * Respiratory virus activity (CDC Respiratory Illnesses) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * UK public health data tracker (UKHSA) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Repeat COVID-19 mRNA vaccination contributes to mucosa immunity (Science Translational Medicine) * XBB.1.5 mRNA booster vaccination limited mucosal immunity (Science Translational Medicine) * I repeat: COVID mRNA booster vaccinations suboptimal respiratory mucosal immunity (Science Translational Medicie) * Facial Palsy after COVID-19 vaccination? (Emerging Infectious Diseases) * New preventive COVID-19 agent (ISDA) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Fusion center near you….if in NY (Prime Fusions) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Viral and symptom rebound following monoclonal antibody therapy (JID) * Drug interaction checker (University of Liverpool) * Nirmatrelvir plus ritonavir reduces COVID-19 hospitalization and prevents long COVID (Scientific Reports) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Time to Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo (JAMA Network Open) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Clinical and functional assessment of SARS-CoV-2 sequelae among young marines * (LANCET: Regional Health Americas) * Letters read on TWiV 1162 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * Continued expansion of type 2 poliovirus (reliefweb) * No more polio case map at polioeradication.org * B/Yamagata removed from flu vaccine (NPR) * Nobel Prizes for miRNA (ScienceInsider) * AAV-vectored influenza vaccine (J Virol) * Herpesvirus type 1 gene drive in mice (Nat Commun) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Virus and Vaccines Information Page from NIH All of Us Research Program Kathy – For a Pivotal Vaccine: Trial, Error and Two Young Lives Rich – October 17 2024 APOD: The Clipper and the Comet Alan – Opening a deep-sea vent with a crowbar Vincent – The expanding world of neuroscience
Listener Pick Jason – Solar eclipse on Mars and Polaris Program and their Harmony of Resilience Ryan – New York’s childhood vaccine coverage remains high
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents, why 65 years and older should get a second boost of the COVID-19 vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, the clinical trial for evaluating how novel treatments of COVID-19 affect long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after SARS-CoV-2 infection.
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Links for this episode * Grim marker: mpox over a 1000 deaths in Africa (CIDRAP) * Global trend of mpox outbreak 2022-2024 (WHO) * Second time mpox is a global public health emergency (Reuters) * Mpox variant in Germany (Reuters) * Epidemiological analysis of confirmed mpox cases in Burundi (EuroSurveillance) * The 63rd case of Marburg virus infections in Rwanda (CIDRAP) * How to stop Marburg virus (Rwanda Biomedical Centre) * Marburg virus fact sheet (Rwanda Biomedical Centre) * FDA approves RSV vaccine ABRYSVO for 18-59 individuals of increased risk (Pfizer) * Respiratory syncytial virus infection-NET (CDC) * New pneumococcal vaccine recommendations…..it’s a virus? (CDC Newsroom) * Recommending PREVNAR 20, 20 valent pneumococcal conjugate vaccine for 50 and over (Pfizer) * And one more, CAPVEXIVE, pneumococcal 21 valent conjugate vaccine (Merck) * Penumococcoal 21-valent conjugate vaccine CAPVEXIVE(MerckVaccines.com) * Influenza surveillance: Key updates (CDC) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * What is happening across the pond? (UKHSA data dashboard) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Risk of SARS-CoV-2 transmission when indoors (JID) * NVX-CoV2327 vs BNT162b2 vaccines in adolescents (Pediatric Infectious Disease Journal) * Second dose of 2024-2025 COVID19 vaccine recommended for 65 and older (CDC Newsroom) * New preventive COVID-19 agent (ISDA) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Viral and symptom rebound following monoclonal antibody therapy (JID) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * ASH living guidelines on use of anticoagulation for thromboprophylaxis in patients with COVID-19: executive summary, Dr. Daniel Griffin (Blood Advances) * Novel treatments for acute COVID-19 should account for long COVID (JID) The persistence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) after SARS-CoV-2 infection (Journal of Infection) * Letters read on TWiV 1160 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden.
Host: Vincent Racaniello Guests: Niklas Björkström and Joakim Dillner
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Links for this episode * MicrobeTV Discord Server * Endometrial immune system variation (Sci Immunol) * Immune defense in the womb (News from Karolinska) * HPV vaccination and screening for elimination (Nat Comm) * Cervical cancer elimination strategies (Int J Cancer) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one’s driving and how long COVID affects Chinese society.
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Links for this episode * Undiagnosed MPXV infections are high in men who have sex with men (BMC Infectious Diseases) * WHO, now a vaccine approval agency, Jynneos for teens (CIDRAP) * Mpox outbreak global trends (WHO) * How to stop Marburg virus (Rwanda Biomedical Centre) * Marburg virus fact sheet (Rwanda Biomedical Centre) * Largest whooping cough outbreak in US in a decade (NPR) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Insurance relates to effectiveness and waning of immunity following 3rd dose of mRNA COVID-19 vaccine? (JID) * New preventive COVID-19 agent (ISDA) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * How well do you test: performance of the SARS-CoV-2 antigen rapid detection test (eBioMedicine) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Remdesivir-associated survival outcomes among immunocompromised patients (CID) * Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients (CID) * Measurement of circulating viral antigens post-SARS-CoV-2 infection (CMI: Clinical Microbiology and Infection) * DUCI: driving under cognitive influence of COVID-19 (Neurology) * Long COVID facts and findings: (LANCET: Regional Health Western Pacific) * Letters read on TWiV 1158 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * Marburg virus disease, Rwanda (WHO) * Suspected German Marburg case tests negative (Politico) * Cryo-EM discovery of insect parvovirus (Cell) * Mosaic sarbecovirus nanoparticle experimental vaccine (Cell) * Letters read on TWiV 1157 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – ASM Lesson Plans Alan – A City on Mars, and this blog by a ham radio operator hit by Hurricane Helene Vincent – How to Win A Nobel Prize
Listener Pick Laura – Science of Public Communication (original article)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK’s recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated but not infected, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if COVID-19 doubles the risk for heart attacks, stroke and death and if COVID-19 affects the regions of the brainstem.
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Links for this episode * Polio: second round of vaccination in Gaza (Reuters) * Season 3 for GSK RSV vaccine protection (CIDRAP) * Positive data for Arexvy, the respiratory syncytial virus vaccine (GSK) * Mpox convicted felon: in Ugandan prison (Reuters) * How to stop Marburg virus (Rwanda Biomedical Centre) * Marburg virus fact sheet (Rwanda Biomedical Centre) * CDC summary of the “Rwanda Marburg Situation” (CDC) * 700 doses of a Marburg vaccine from the Sabin Vaccine Institute to Rwanda (CIDRAP) * USAID mobilizes Marburg outbreak response in Rwanda (United States Agency International Development) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * PICOBOO: immunogenicity, reactogenicity and safety of different COVID-19 vaccine (Journal of Infection) * COVID-19 in previously unvaccinated compared with previously uninfected vaccinated (JID) * New preventive COVID-19 agent (ISDA) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * COVID Data tracker (CDC * Differences in COVID-19 outpatient antiviral treatment (MMWR) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * COVID-19 is a coronary artery disease with genetic interaction with ABO blood type (AHAIASA Journals) * COVID-19 doubles risk of heart attack, stroke and death (EurekaAlert!) * QTL mapping at 7T in COVID-19: brainstem and outcomes (Brain) * Letters read on TWiV 1156 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
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Links for this episode * MicrobeTV Discord Server * Review confirms mask effectiveness (original article) * EEE death in Ulster County NY (CBS News) * EEE on TWiV 1145 * Viruses of farmed fur animals (Nature) * Tracing of wildlife and viruses at COVID-19 epicenter (Cell) * Letters read on TWiV 1155 * Timestamps by Jolene. Thanks!
Weekly Picks Rich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions Alan – Birdcast Vincent – A universal framework for inclusive 15-minute cities
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume.
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Links for this episode * Rwanda: Marburg virus disease (WHO) * Passport required?…..Marburg virus commutes to Germany (CIDRAP) * Outbreak of whooping cough/pertussis…..no lifelong immunity following vaccination? (Bloomberg * Protection of infants by maternal antibodies against RSV by either vaccination or nirsevimab (MMWR) * WHO recommendations for RSV: maternal vaccination and antibody shot (Reuters) * Ziresovir for RSV hospitalized infants (NEJM) * Crawling to effective anti-RSV countermeasures (NEJM) * The $800 million pledge for African mpox response (Reuters) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Doffing your PPE– contact precautions (CID) * mRNA vaccination does not elicit durable immune response (Nature Medicine) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Mechanisms of long COVID and therapeutics (Cell) * Post hospitalization cognitive deficits and grey matter reduction 1 year after COVID-19 (Nature Medicine) * Letters read on TWiV 1154 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections.
Hosts: Vincent Racaniello and Jolene Ramsey
Guests: Krystyna Dabrowska and Rob Lavigne
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Links for this episode * MicrobeTV Discord Server * Viruses of Microbes 2024 * Immune responses to phages (Front Immunol) * Engineering bacteriolytic enzymes (Front Immunol) * 100 cases of phage therapy (Nat Micro) * Synthetic biology potential of bacteriophages (Nat Micro) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition.
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Links for this episode * Waning vaccine protection against mpox…..isn’t this the way the humoral immune response works? (CIDRAP) * Uncontrollable mpox outbreak in Africa (Reuters) * Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can you believe? (medrxiv) * Mpox vaccine for adolescents approved (Pharmaceutical Technology) * Clade 1b mpox visiting India (CIDRAP) * Mpox clade 1b in Kerala (ANI South Asia’s Leading Multimedia News Agency) * US government orders $63M worth of small pox/mpox vaccine (Reuters) * Mpox donations boosting global supply (US Department of Health and Human Services) * I million mpox vaccine doses for Africa….with love from US government (CIDRAP) * Speed doses of mpox vaccine (CIDRAP) * Mpox vaccine donations (UNICEF) * Bavarian Nordic mpox vaccine (Yahoo finances) * Early epicenter of COVID-19 pandemic Huanan seafood market (Science) * Wildlife trade likely source of SARS-CoV-2 (Science) * Zoonotic origins of SARS-CoV-2 (Science) * Surveillance at the Huanan Seafood market (Europe PMC) * TWiV shout outs…..all for the SARS-CoV-2 spill over from nature + TWiV 1019: Eddie Holmes on SARS-CoV-2 origins + TWiV 1017: From Nature, not a lab + TWiV 995: Viral origin stories + TWiV 940: Eddie Holmes in on viral origins + TWiV 876: Spillover market with Michael Worobey + TWiV 762: SARS-CoV-2 origins with Robert Garry + TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans + TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences * Genetic tracking of market wildlife and viruses at Huanan Market (Cell) * Combatting scientific misinformation (microbeTV: TWiV) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Suggestion for the use of a new preventive COVID-19 agent (IDSA) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases) * Antivirals and post-COVID-19 conditions (LANCET Infectious Disease) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Lower mortality risk associated with remdesivir + dexamethasone versus dexamethasone for hospitalized COVID-19 patients (CID) * Changes in memory and cognition during the SARS-CoV-2 human challenge study * (eClinical Medicine) * Letters read on TWiV 1152 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
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Links for this episode * MicrobeTV Discord Server * Polio vaccination in Gaza (Reuters) * Zoonotic viruses in farmed fur animals (Nature) * HPV vaccination and cancer rates (JAMA Net Open) * 40 kb RNA genome without error correction (PNAS) * Stopping the phage tape measure protein (Nat Commun) * Tail assembly interference (Nat Commun) * Letters read on TWiV 1151 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum Vincent – The collapse of bat populations led to more than a thousand infant deaths
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal IgA in response to SARS-CoV-2 infection, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravir treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if those taking the anti-diabetic drug metformin have higher or lower incidences of long COVID.
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Links for this episode * West Nile virus in New Jersey (CBSNews) * Poliovirus vaccination 90% coverate (Reuters) * Suspension of poliovirus eradication by the Taliban (apnews) * California dengue cluster (CIDRAP) * Children dying of influenza (CIDRAP) * 199 children deaths from flu (CDC) * Bavarian Nordic mpox vaccine (Yahoo finances) * Prequalification of MVA-BN mpox vaccine (WHO Int) * Speed doses of mpox vaccine (CIDRAP) * GAVI rapidly secures 500K doses of mpox vaccines for Africa(GAVI) * Expanded access to teconvirimat for mpox treatment in US 2022-2023(NEJM Evidence) * FluView (CDC) * Human to human transmission of bird flu in Missouri? (NY Times) * Bird flu isolated from humans in Missouri similar to that found in cattle (CNN) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * Waste water scan for 11 pathogens (WastewaterSCan) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage (CID) * Early, robust mucosal secretory IgA but not IgG response to SARS-CoV-2 spike in oral fluid is associated with faster viral clearance and COVID-19 symptom resolution (JID) * Suggestion for the use of a new preventive COVID-19 agent (IDSA) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Lierpool) * Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases) * Antivirals and post-COVID-19 conditions (LANCET Infectious Disease) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Metformin use in adults with diabetes and incidence of long COVID (Diabetes Care) * Letters read on TWiV 1150 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus.
Hosts: Kathy Spindler and Brianne Barker Guest: Mary Estes
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Links for this episode * MicrobeTV Discord Server * Diarrhea induced by rotavirus NSP4 (Science) * Minimal infective dose of rotavirus (Arch Virol) * mRNA release from rotavirus particles (Nat Struct Biol) * Norovirus vaccine (Clin Ther) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones’ micriobiota.
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Links for this episode * Lending you the viruses in my fur (Nature) * mRNA or vaccinia based mpox vaccine (Cell) * Virtual outpatient management of mpox (OFID) * NYC: mpox vaccination finder (NYC) * Vaccine, mpox/COVID-19 near you (NYC) * Expensive or not expensive anti-RSV monoclonal therapy for infants (American Academy of Pediatrics) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Association of vaccination and SARS-CoV-2 viral load phase 3 (JID) * IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Early phase of SARs-CoV-2 infection (COVID.gov) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases) * Antivirals and post-COVID-19 conditions (LANCET Infectious Disease) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID following infection with Omicron: oral microbiota changes(American Journal of Medicine) * Letters read on TWiV 1148 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * Multi-country Mpox outbreak (WHO) * Face covering ban in Nassau County (NBC) * Polio case in India (Business Standard) * More acceptance of vaccine misinformation (EurekAlert) * War in Gaza not just causing polio (Jerusalem Post) * Scientist run virus genome database (Science) * Mpox epidemiology and vaccine effectiveness (Emerg Inf Dis) * Newborn vulnerability to norovirus diarrhea (Cell Host Microbe) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Viral adaptation to climate change Rich – “Understanding the biology of monkeypox virus to prevent future outbreaks” by B. Moss Vincent – We can now watch Grace Hopper’s famed 1982 lecture on YouTube
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID.
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Links for this episode * Recommendations for seasonal influenza prevention and vaccines (MMWR) * Gaza: poliovirus RNA in sewage water (Reuters) * Success of the polio vaccination campaign in Gaza (Reuters) * UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi) * mpox vaccine tender (CIDRAP) * What about vaccines? (Bavarian Nordic) * Resolving food insecurity (UNICEF USA) * Semaglutide and the SELECT trial(Journal of the American College of Cardiology) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Optimal duration of systemic corticosteroids treatment (OFID) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Does vaccination prevent long COVID (LANCET: Respiratory Medicine) * Fibrin drives thromboinflammation & neuropathology in COVID-19(Nature) * Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID) * Letters read on TWiV 1146 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * Gaza baby has polio (Times Israel) * Monkeypox virus clade Ib in Thailand (CIDRAP) * Updated COVID-19 vaccines (FDA) * Effectiveness of Ebola virus vaccine (Lancet Inf Dis) * Measles cases in Georgia, Oregon (CIDRAP) * Retrovirus protein regulates cardiomyocyte development (Cell Stem Cell) * Receptor shifts govern submergence of encephalitis arbovirus (Nature) * Letters read on TWiV 1145 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Googlegangers and AWWW clip Rich – RP FLIP (floating instrument platform) Alan – Big labs are bad for careers Vincent – So You’re Underwater: Why Do You See That Circle of Light Above You?
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.
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Links for this episode * Fauci recovering at home from West Nile Virus infection (STAT News) * Gaza: poliovirus RNA in sewage water (GPEI) * Bombs and polio…..cease fire, Oh my! (Guardian) * The variant type 2 poliovirus in Gaza (United Nations: The Question of Palestine) * 25 years polio free? (Facebook) * 2 doses of nOPV2= 1.2M vaccines=640,000 children (CNN) * More polio……India, two-year-old child in Tikrikilla, Meghalaya (Business Standard) * Sloth fever……Oropouche virus (USA Today) * Oropouche virus disease import into US (MMWR) * Gabon’s first case of mpox (CIDRAP) * Declaration of mpox (Gabonese Republic Ministry of Health and Social Affairs) * What about vaccines? (Bavarian Nordic) * LC16 replicating smallpox vaccine (WHO) * Historical smallpox vaccination against mpox clade II (Eurosurveillance) * FDA approves Emergent Bio’s smallpox vaccine for mpox (Reuters) * Mpox: epidemiology and vaccinology (Emerging Infectious Disease) * Tecovirimat for MPOX? (STOMP) * UGH! The WHO has a strategic preparedness and response plan to contain mpox outbreak (WHO) * WHO preparedness plan prepares to lunch (CIDRAP) * Working blindly against new mpox isolate (Reuters) * CDC monkey pox response: TRANSMISSION ? (CDC Newsroom) * The mpox (Africa CDC: Centers for Disease Control and Prevention) * Evidence for mpox respiratory transmission(LANCET Microbe) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * SARS-CoV-2 genomes galore (Nextstrain) * Four free COVID tests! (ASPR: Administration for Strategic Preparedness & Response) * Great, more SARS-CoV-2 testing! (CIDRAP) * EUA for updated Novavax COVID-19 vaccine (FDA) * Infectious Disease Society guidelines for treatment and management (ID Society) * IDSA suggests new preventive COVID-19 agent (IDSA) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Breakthrough from pemivibart/permgarda (bioRxiv) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Effectiveness of nirmatrelvir/ritonavir preventing hospitalization of high risk patients (Current Therapeutic Research) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * COVID-19, mental illness vaccinated and unvaccinated (JAMA Psychiatry) * Post acute COVID- 19 outcomes amubarvimab/romlusevimab versus placebo (eClinical Medicine) * Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID) * Fibrin drives thromboinflammation & neuropathology in COVID-19 (Nature) * Letters read on TWiV 1144 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * Mpox outbreak is PHEIC (WHO) * Tecovirimat not great against monkeypox virus clade I (NIH) * Case of Mpox Clade I in Sweden (PHAS) * Mpox and pets in USA (Emerg Inf Dis) * SARS-CoV-2 widespread in wildlife communities (Nat Comm) * Salivary GAPDH benefits plant virus transmission (Nat Comm) * Letters read on TWiV 1143 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – NASA Confirms Evidence That Liquid Water Flows on Today’s Mars Kathy – TBP for PCR internal control Rich – xmACIS2 compares the data in the ACIS database to that in GHCN-Daily Alan – Larry, the world’s most highly cited cat Vincent – The Viral Paleontologist Who Unearths Pathogens’ Deep Histories
Listener Pick Ryan – Mpox emergencies AP News one and two Rona – Up in smoke David – Ode to Joy (YouTube, TikTok)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents.
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Links for this episode * mpox epidemic caused by monkeypox clade I in affected African countries (European Centre for Disease Prevention and Control) * mpox in Pakistan (Reuters) * mpox imported into Pakistan (UNMC Global Center for Health Security) * mpox domesticated in Taiwan (Focus Taiwan: CAN English News) * clade IIb not Ib in Taiwan (bne Intellinews) * WHO: mpox public health emergency of global care (NY Times) * Vaccines didn’t turn back mpox…..people did (NY Times) * Deadlier mpox version in Thailand (NY Times) * Antiviral tecovirimat….not so much (NIH News) * What about vaccines? (Bavarian Nordic) * Invest or not to invest Barvaian Nordic pox vaccine manufacturer? (Yahoo! Finance) * US to support Africa’s mpox response (CIDRAP) * $35M to support mpox outbreak response in central and eastern Africa (USAID From the AMERICAN PEOPLE) * COVID-19 deaths (CDC) * COVID-19 national and regional trends (CDC) * COVID-19 variant tracker (CDC) * FDA approves and authorizes updated mRNA COVID-19 vaccines (FDA) * Novavax still working on updated COVID-19 vaccine (novavax) * COVID-19 variant update (CDC & IDSA) * Economic benefit of annual COVID-19 vaccination (JID) * Early COVID-19 XBB.1.5 vaccine effectiveness (Influenza and other respiratory viruses) * Uptake of COVID-19 vaccines and associated hospitalization due to COVID-19 in pregnancy (Vaccine) * Novavax heterologous booster demonstrates lower reactogenicity (JID) * Where to get pemgarda (Pemgarda) * EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) * Breakthrough from pemivibart/permgarda (bioRxiv) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What to do when sick with a respiratory virus (CDC) * When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID differs in children and adolescents (JAMA Network) * Letters read on TWiV 1142 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * Mpox widespread in Africa (CIDRAP) * Africa declares Mpox emergency (Science) * COVID drops to 10th leading cause of US deaths (MMWR) * Response to detection of poliovirus in Gaza (WHO) * Molecular mimicry in MIS-C (Nature) * Neonatal Fc receptor is pan-arterivirus receptor (Nat Comm) * Antiviral immunity in plants by protein arginine methytransferase 6 (Cell Host Micr) * Letters read on TWiV 1141 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Kate Douglass: Olympian and Statistician (Swimming in Data) Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha’Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women’s basketball team Rich – Texas State University Forensic Anthropology Research Facility Vincent – Sea lion ‘camera crews’ capture new footage of ocean floor
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.
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Links for this episode * Measles transmission after secondary vaccination failure (Emerg Inf Dis) * Mpox public health emergency of international concern (WHO) * First case of new mpox strain outside of Africa (Reuters) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Where to get pemgarda (Pemgarda * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * Individual monoclonal antibodies against SARS-CoV-2 should be used (CID) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID science, research and policy (Nature Medicine) * Measurements of prior SARS-CoV-2 infection and postacute sequelae by the clinical laboratory (Annals of Internal Medicine) * Risk factors for long COVID syndrome in postmenopausal women with previous SARS-CoV-2 infections (Annals of Epidemiology) * New studies estimate long-COVID rates, identify risk factors (CIDRAP) * Monitoring long COVID via telemedicine (PLoS One) * Letters read on TWiV 1140 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.
Hosts: Vincent Racaniello
Guest: Judith Bruchfeld
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Links for this episode * MicrobeTV Discord Server * Immune system perturbations in Long COVID (J Immunol) * Post-COVID immune system perturbations (J Immunol) * Systems disregulation in Long COVID (Sci Rep) * Clincal standards for diagnosing, treating, and preventing Long COVID (Intl J Tuberc Lung Dis) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.
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Links for this episode * Harms of the lab leak hypothesis (Journal of Virology) * Lab leak mania (PaulOffit, Substack) * This is a special message: pandemic started in nature! (TWiV) * RSV vaccine recommendations August 6 2024 (MMWR) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Where to get Pemgarda (Pemgarda) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) Long COVID defined (NEJM) * Contribute to our Floating Doctors fundraiser * Lenacapavir on Puscast #60 * Letters read on TWiV 1138 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * PrEP with HIV-1 capsid inhibitor (NEJM) * WHO pandemic plan (pdf) * West Nile virus resurgence in US (NY Times) * Properties of BANAL SARS-CoV-2 like viruses (Nat Micro) * BANAL viruses on TWiV 809 * Different effect of dengue virus amino acid change in humans and mosquitoes (Sci Transl Med) * Eng Ong Ooi on TWiV 633 * Letters read on TWiV 1137 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Using big data to improve traffic light timing Rich – Dillo Dirt Alan – Dueling Banjos on banjo and kora Vincent – The world’s most expensive dinosaur and more
Listener Pick Mike – Science through a glass darkly Lisa – On A Mission“ Season Four
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.
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Links for this episode * In physicians and hospitals, we trust (JAMA Network) * Are there benefits for delaying seasonal influenza vaccine selections (JID) * Personal protective effect for wearing surgical face masks in public spaces (the BMJ) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Cardiovascular safety of different COVID-19 vaccination(Nature Comm) * Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine) * Where to get pemgarda (Pemgarda) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology) * Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health) * Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine) * The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1136 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * What’s going on with measles? (J Virol) * Poliovirus in Gaza (Science) * Sanitation concerns in Gaza (AP) * Community vaccine beliefs (PLoS One) * 14 year old dies of Nipah in India (Hindustan Times) * Selection of nirmatrelvir resistance mutants (Sci Adv) * CCHFV monoclonal antibodies (Cell Rep) * CCHFV vaccine (TWiV 565) * Prometheus Project (TWiV 578) * TWiV at USAMRIID (TWiV 1015) * Letters read on TWiV 1135 * Timestamps by Jolene. Thanks!
Weekly Picks Angela – Animal research is not always king Brianne – Why the US has more tornadoes than any other country Dickson – Earth’s core has slowed so much it’s moving backward Alan – Article about the Smithsonian’s forensic ornithology lab, led by Carla Dove Vincent – Seventh patient ‘cured’ of HIV: why scientists are excited
Listener Pick Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.
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Links for this episode * Clesrovimab, RSV preventative monoclonal antibody for infants (Merck) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Characterizing SARS-CoV-2 reinfections and long COVID (Communications Medicine) * Cost-effectiveness of COVID rapid diagnostic tests (PLoS Medicine) * NVX-CoV2373 against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID) * Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization(CID) * Pemgarda infusion center locator (Pemgarda) * Respiratory virus guidance (CDC) * Early phase of SARS-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection(Nature Aging) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1134 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * Measles in Brooklyn NY (ABC) * Measles in Washington DC (DC Health) * Global childhood immunization stalls (WHO) * Licensed H5N1 vaccines protect against circulating strains (Nat Med) * Viruses moving without passports (European CDC) * OC42-SARS-CoV-2 replacement spike virus (PNAS) * Deep mutational scanning of Lassa virus glycoprotein (Immunity) * Letters read on TWiV 1133 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Elemental sulfur found on Mars Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024 Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?) Alan – Nature sent an investigative reporter to a predatory conference Vincent – Coal-filled trains are likely sending people to the hospital
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.
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Links for this episode * President Biden has COVID (CNN, USA Today) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Post–acute sequelae of COVID after infection during pregnancy (OB & Gyn) * Oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 (NEJM) * Pemgarda infusion center locator (Pemgarda) * Unable to access pemgarda, gotta call Daniel (microbeTV) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Combined treatment of COVID reduces molnupiravir-induced mutagenicity (J Inf Dis) * Effectiveness of ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19 (Inf Dis Therapy) * Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy (Lancet) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Isolation guidance (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID is defined (National Academies) * Long COVID: the ANSWERS! (longcovidtheanswers.com) * The FACTS: post COVID-19=long COVID? (WHO) * The BASICS of long COVID-19 (CDC) * Postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras (NEJM) * Long Covid risk has dropped over time but remains substantial (CNN) * Efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID (Clin Micro Inf) * Diet and the gut microbiome: implications for health and disease (Nat Rev Micro) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1132 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
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Links for this episode * MicrobeTV Discord Server * Articles on Chevron decision (one, two, three) * Measles in New Hampshire and Vermont (NH DHHS) * Pathogenicity and transmission of bovine H5N1 virus (Nature) * Letters read on TWiV 1131 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Stockholm Wood City Rich – “The Wide Wide Sea” by Hampton Sides Vincent – Tour de France stage 12
Listener Picks Amy – Earth Forced from the Protective Heliosphere: What Do We know?
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF.
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Links for this episode * H5N1: birds and cows oh, my…..Michigan and Colorado (CIDRAP) * Flu pandemic for the Colorado chicken (Colorado Sun) * It’s a disaster: Avian flu in Weld county (Colorado.gov) * More 9.7 million dengue cases in US this year: CDC issues warning (Patch.com) * Long Island has DENGUE! (Long Island News12) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Association between proton pump inhibitors and COVID-19 susceptibility or severity in children? (Journal of Pediatrics) * Where to get pemgarda (Pemgarda) * Unable to access pemgarda, gottacall Daniel (microbeTV) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Benefits of desamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell) * Anticoagulation guidelines (hematology.org) * Long COVID: the ANSWERS! (longcovidtheanswers.com) * The FACTS: post COVID-19=long COVID? (WHO) * The BASICS of long COVID-19 (CDC) * Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (CDC) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1130 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews measles in Kenya, a trial for a intranasal COVID vaccine, dengue in the Florida Keys and in Central/South America, Spain connecting government with scientists, T cell activation and viral RNA fragments persist for up to 2 years after SARS-CoV-2 infection, and durable cross-reactive and protective antibodies against avian N2 neuraminidases elicited by A(H2N2) and A(H3N2) influenza pandemics.
Hosts: Vincent Racaniello and Alan Dove
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Links for this episode * MicrobeTV Discord Server * Measles in Kenya (WHO) * Intranasal COVID vaccine trial (NIH) * Dengue in Florida Keys (Florida Health) * Dengue rising in Central/South America (NPR) * Spain to connect scientists with government (Science) * Persistence of T cells and viral RNA after SARS-CoV-2 infection (Sci Transl Med) * Influenza pandemics induce cross-reactive antibodies against avian N2 (Nat Comm) * Letters read on TWiV 1129 * Timestamps by Jolene. Thanks!
Weekly Picks Alan – The first few minutes of this video by Roger Barnes Vincent – Billy & Molly: An Otter Love Story
Listener Picks Fernando – A City on Mars
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of “pasteurization” before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we observed 2 years following SARS-CoV-2 infection for tissue-resident T cell and viral RNA persistence.
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Links for this episode * Fourth case human infection associated with an ongoing multistate outbreak of A(H5N1) (CDC) * Human H5N1 in Colorado and thedefinition of pasteurization (CIDRAP) * Is “raw” milk more risky than pasteurized (Annenberg Public Policy Center) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Winter, spring, summer and fall COVID-19 surges? (CDC) * Where to get pemgarda (Pemgarda) * Unable to access Pemgarda, gotta call Daniel (microbeTV) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Molunpiravir works: reduces hospitalizations and deaths due to COVID-19 and all-cause mortality (CID) * Convalescent plasma recommendation for immunocompromised (ID Society) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Benefits of dexamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell) * Anticoagulation guidelines (hematology.org) * EEG signatures for cognitive decline after SARS-CoV-2 infection (BMC Medicine) * Tissue resident T-cells and viral RNA 2 years after SARS-CoV-2 infection (Science Translational Medicine) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1128 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor’s subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
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Links for this episode * MicrobeTV Discord Server * Pentagan anti-vac campaign to undermine China (Reuters) * NY governor subway mask ban (AP News) * Colorado bat facility sparks outbreak fears (Science) * House NIH budget bans gain of function research (Science) * Evolution of STAT2 resistance to flavivirus NS5 (Nat Commun) * Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science) * Letters read on TWiV 1127 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and “kitten season.” Vincent – Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking
Listener Picks Blog design – Trump vows to defund schools requiring vaccines for students Jon – Detections of highly pathogenic avian influenza in mammals
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID.
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Links for this episode * CDC ACIP for RSV (CDC) * This respiratory virus season everyone age 75 and older receive the RSV vaccine (CDC Newsroom) * Revised RSV vaccine recommendations (CIDRAP) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Local and systemic response dynamics to SARS-CoV-2 infection (Nature) * Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience) * Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN) * Do older versions of the COVID-19 vaccine still provide any protection (JAMA Internal Medicine) * Where to get pemgarda (Pemgarda) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Adjuvant statin therapy reduces SARS-CoV-2 mortality (American Journal of Medicine) * Nirmatrelvir and ritonavir beyond 5 days of symptom onset improved the multiple organ dysfunction in severe COVID-19 patient (BMC Infectious Disease) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Faecal microbtiota transplantation cures sleep disturbance in post-acute COVID-19 syndrome (Clinical Gastroenterology and Hepatology) * Long COVID defined by patient phenotype (CIDRAP) * Three distinct symptom-based post-COVID condition phenotypes (JID) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1126 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews criticism of NIAID monkeypox virus experiments by House Republicans, spread of wild poliovirus across Afghanistan and Pakistan, plan to overhaul NIH by House lawmakers, and the potential pandemic risk of circulating swine H1N2 influenza viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * 2024 International HBV Meeting * House Republicans fault NIH for evasive answers on monkeypox virus study (Science) * Report on MPX experiments at NIAID (pdf) * Wild poliovirus spreads across Pakistan and Afghanistan (Science) * Plan to overhaul NIH (Science) * Reforming NIH (pdf) * Potential pandemic risk of circulating swine H1N2 influenza viruses (Nat Comm) * Timestamps by Jolene. Thanks!
Weekly Picks Angela – Staring at the Sun — close-up images from space rewrite solar science Brianne – Water frost detected on Mars Volcanos Dickson – Best view yet of the Crab Nebula Vincent – Will Your Tattoo Give You Cancer: Probably Not…but Maybe?
Listener Picks Jessica – Manchurian plague
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person’s time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals.
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Links for this episode * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Comparison of methods for sterilizing filtering facepiece respirators (American Journal of Infection Control) * Booster update already! KP.2 of JN.1-lineage (FDA) * EUA for pemgarda (FDA) * Where to get pemgarda (Pemgarda) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (ID Society) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (ID Society) * Revisiting monoclonal antibody therapy, sotrovimab for treatment during Omicron BA.2 and BA.5 (Infection) * What do when your healthcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Hospital nurse staffing variation & COVID-19 (International Journal of Nursing Studies) * Endothelial dysfunction and persistent inflammation severe post-COVID-19 (BMC Medicine) * Prevalence and risk for CMV reaction due to COVID-19 pneumonia (PLoS One) * Variables that impact recovery from acute SARS-CoV-2 infetion (JAMA Network Open) * Reduced olfactory bulb volume with dysfunction after mild SARS-CoV-2 inction (Scientific Reports) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1124 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to Europic 2024 in Jyväskylä, Finland to speak with Tapani Hovi and Caroline Tapparel about their careers and their research on enteroviruses and elimination of poliomyelitis.
Host: Vincent Racaniello
Guests: Tapani Hovi and Caroline Tapparel
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Links for this episode * Survival of influenza virus on banknotes (Appl Environ Micro) * Variant EV-A71 in immunosuppressed patient (Cell Rep) * Rhinoviruses and respiratory enteroviruses (Viruses) * Isolation of poliovirus in mouse cells producing Pvr (J Clin Micro) * Outbreak of paralytic poliomyelitis in Finland (Lancet) * Role of environmental poliovirus surveillance in global polio eradication(Epi Infect) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin discusses expanded use of the RSV vaccine by GSK, how the youngest member of the MicrobeTV family was hospitalized with RSV, why we are seeing more RSV infections than before the pandemic and how administration of monoclonal antibody therapy does not prevent infection but disease, before reviewing the weekly US COVID update, how SARS-CoV-2 affects neurodevelopment of the fetus and probability of preeclampsia, if giving Paxlovid prevents long COVID, and FDA recommends switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations.
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Links for this episode * Young “Immune” co-host with RSV (YouTube) * RSV on Immune (MicrobeTV) * More children hospitalized with RSV after pandemic than before (Pediatrics) * France supports Nirsevimab for RSV (Influenza and other respiratory viruses) * Protects against disease not infection Nirsevimab (CIDRAP) * TWiV tells it likes it is: protects against disease NOT infection (TWiV 695) * RSV vaccine access expanded 50-59 (CIDRAP) * GSK RSV vaccine expanded use for high risk 50-year olds (GSK) * COVID-19 deaths * COVID-19 national trend * Neurodevelopmental delay in children whose mothers exposed to SARS-CoV-2 (Scientific Reports) * Preeclampsia associated with SARS-CoV-2 infection (Journal of Maternal-Fetal & Neonatal Medicine) * Effectiveness of nirmatelvir/ritonavir in children and adolescents (Nat Comm) * JN.1 for fall COVID-19 boosters (FDA) * COVID-19 vaccine booster switch (CIDRAP) * EUA for pemgarda (FDA) * Infusion centers near you! (pemgarda.com) * CDC quarantine guidelines (CDC) * Early phase of SARS-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (IDSociety) * Drug interaction checker (University of Liverpool) * Molnupiravir safety and efficiacy (JMV) * Convalescent plasma recommendations for immunocompromised (ID Society) * Updated respiratory virus guidelines (CDC) * What to do when your healthcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staff shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Nirmatrelvir-ritonavir prevents long COVID-19? (JAMA Medicine) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1122 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature). This material has been extracted from TWiV 1121.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey
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Links for this episode * MicrobeTV Discord Server * SARS-CoV-2 origin discussions previously on TWiV: + TWiV 1019: Eddie Holmes on SARS-CoV-2 origins + TWiV 1017: From Nature, not a lab + TWiV 995: Viral origin stories + TWiV 940: Eddie Holmes in on viral origins + TWiV 876: Spillover market with Michael Worobey + TWiV 762: SARS-CoV-2 origins with Robert Garry + TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans + TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences * Why the Pandemic Probably Started in a Lab, in 5 Key Points (NY Times) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature), followed by a discussion of Paride bacteriophage, which has the unsual property of being able to kill dormant, antibiotic-tolerant cells by direct lytic replication.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey
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Links for this episode * MicrobeTV Discord Server * 2024 International HBV Meeting * Register for ASV Annual Meeting * SARS-CoV-2 origin discussions previously on TWiV: + TWiV 1019: Eddie Holmes on SARS-CoV-2 origins + TWiV 1017: From Nature, not a lab + TWiV 995: Viral origin stories + TWiV 940: Eddie Holmes in on viral origins + TWiV 876: Spillover market with Michael Worobey + TWiV 762: SARS-CoV-2 origins with Robert Garry + TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans + TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences * Why the Pandemic Probably Started in a Lab, in 5 Key Points (NY Times) * Phage Paride kills dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa (Nat Comm) * Interview with Enea Maffei (Spotify) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – How to build a nuclear warning for 10,000 years’ time Rich – Doctor My Eyes | Jackson Browne Alan – WHO Health for All Film Festival winners Jolene – El enemigo de mi enemigo es mi amigo Vincent – A Population Dotmap of New York City and Race and Ethnicity in New York City
Listener Picks David – The greatest clock (and map) ever made Peter – The Mouse as a Microscope
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna’s mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks and respirators as source control for viral aerosol shedding from people infected with SARS-CoV-2, systematic review of early use of oral antiviral drugs and the risk of post COVID-19 syndrome, long-COVID autonomic syndrome in working age and work ability impairment, Centers for Disease Control and Prevention estimates that 5.3% of Americans currently have long COVID, and the National Academies of Sciences, Engineering, and Medicine presented a report with a number of conclusions about long-COVID diagnosis, symptoms, and impact on daily function.
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Links for this episode * Links coming soon * Long COVID evidence based review TWiV shout out * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1120 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews viral shedding and antibody responses of men with acute monkeypox virus infection, and gene editing for latent herpes simplex virus infection reduces viral load and shedding.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * 2024 International HBV Meeting * Michelson Prizes: Next Generation Grants * Register for ASV Annual Meeting * Monkeypox virus shedding (Nat Commun) * Gene editing of herpes simplex virus (Nat Commun) * Letters read on TWiV 1119 * Timestamps by Jolene. Thanks!
Weekly Picks Angela – Unconventional Sex Let Anglerfish Conquer the Deep Ocean Kathy – Doonesbury from 5-26-24. And Publish or Perish game Rich – Sky: Giant Sunspot Region 3664 and Resulting Auroras APOD video Vincent – Mysterious sea urchin plague is spreading through the world’s oceans
Listener Pick Abdulaziz – Biomedical Scientist Answers Pseudoscience Questions
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Content in this podcast should not be construed as medical advice.
In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database, absence of durability of XBB.1.15 vaccine induced immunity and continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and discusses why development of long COVID should be included in the development of treatments for acute viral disease, if vaccination effects long COVID, structural impairment of brain during long COVID, how cognitive and respiratory function may be compromised in long COVID. For more information about long COVID-19 listen to TWiV 1088 and for H5N1 in dairy cattle and unpasteurized milk TWiV 1117.
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Links for this episode * Bird dogs infected with high pathogenic avian flu H5N1(AKC) * Hunting dogs with antibodiesagainst influenza A (H5N1) (Emerging Infectious Diseases) * Dairy cattle and 2 humans infected with highly pathogenic avian influenza A (H5N1) (MMWR) * Daisy, are you reading NEJM: cow’s milk infected with highly pathogenic avian influenza A (H5N1)? (NEJM) * Better yet, listen TWiV 1117: pol dances with RNA to learn if mice can transmit H5N1 to each other * Alpacasinfected with for highly pathogenic avian influenza A (H5N1) (CIDRAP) * USDA is now inspecting for highly pathogenic avian influenza A (H5N1) in alpacas in Idaho (USDA APHIS) * COVID-19 deaths * COVID-19 national trend * Risk factors for pediatric critical COVID-19 (JPIDS) * Kids and their underlying conditions for increased risk for severe COVID-19 (CIDRAP) * SARS-CoV-2 transmission during airline flights (Environmental Research and Public Health) * Spring vaccine advice(CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practice slides(CDC) * Really, durable immune response of XBB.1.5 vaccines against Omicron subvariants (NEJM) * EUA for pemgarda(FDA) * Infusion centers near you! (pemgarda.com) * CDC quarantine guidelines (CDC) * Early phase of SARS-CoV-2 infection (COVID.gov) * NIHCOVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelinesfor treatment and management (IDSociety) * Drug interaction checker (University of Liverpool) * Molnupiravirsafety and efficiacy (JMV) * Convalescent plasma recommendations for immunocompromised (IDSociety) * Updated respiratory virus guidelines (CDC) * What to do when your healthcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staff shortages (CDC) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Post COVID-19 following virus vaccination (Nat Comm) * Why include long COVID-19 when developing novel treatments for acute disease (JID) * Cerebral microstructural alterations post COVID-19 cognitive, memory and fatigue (Nat Comm) * Cognitive impairment prevalence and co-occurrence in children and young adults 12 months after Omicron infection (Brain) * Persistent static lung hyperinflation and small airway dysfunction in long COVID (Respiratory Research) * Long COVID evidence based review TWiV shout out * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1118 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows. dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * 2024 International HBV Meeting * Michelson Prizes: Next Generation Grants * Register for ASV Annual Meeting * H5N1 influenza virus in raw cow milk infects mice (NIAID News) * Dynamics of measles virus immunity from birth (Nat Comm) * Mechanism of cis-preferential HBV reverse transcription (Cell) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Oldest virus in Neanderthal bones Brianne – Jeopardy! winner reveals entwined memory systems make a trivia champion Kathy – Bright future of intelligent fabrics primary article and Self-dyeing textiles (primary article) Rich – Farewell to HD Atlas; Boston Dynamics Retires HD Atlas Robot Alan – Why vaccinating cattle against H5N1 is hard Vincent – Singapore Airlines turbulence: why climate change is making flights rougher
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin delves highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database and the global phase 3 trail of a novel antiviral, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, reminisces about when available monoclonal antibody therapies were effective, and discusses muscle training/exercise for treatment of PASC/long COVID and the use of RNase for its treatment. For more information about long COVID-19 listen to TWiV 1088.
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Links for this episode * Clade 2.3.4.4b of highly pathogenic H5N1 in NYC (J Vi) * Avian and human influenza A receptors in bovine mammary glands (bioRxiv) * Where livestock infected with HPAI live (USDA) * Another dairy worker contracted bird flu (NY Times) * Reluctance to test for H5N1 (STAT News) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Estimates of hospitalization and deaths prevaccination era (Emerg Inf Dis) * Slightly less than half of COVID-19 patients died prevaccination (CIDRAP) * How to undress in the time of COVID-19 (CID) * Spring vaccineadvice (CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practices slides (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (IDSociety) * Drug interaction checker (University of Liverpool) * Global phase 3 study of ensitrelvir (Shionogi) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Updated respiratory virus guidances (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Remember when monoclonal antibody therapies worked (JID) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Global clinical study of long COVID-19 (International Journal of Infecitous Diseases) * Cardiopulmonary exercises testing of children with long COVID-19 (Pediatric Infectious Disease Journal) * Phase 2 trial of RSVL-132 for severe fatigue related to PASC (CID) * Muscle training may improve diaphragm muscle weakness 2 years after COVID-19 (American Journal of Respiratory Critical Care Health) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1116 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews results of a phase 3 trial of a self-amplifying mRNA COVID-19 vaccine, and the finding that baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology.
Hosts: Dickson Despommier, Alan Dove and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Michelson Prizes: Next Generation Grants * Immunogenicity and safety of self-amplifying mRNA COVID-19 vaccine (Lancet Inf Dis) * First self-amplifying mRNA vaccine approved in Japan (Science) * Rise of the RNA machines (Trends Biochem) * Innate and T cell populations correlates of protection against influenza (Nat Immunol) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson - Nitrogen-fixing organelle in a marine algaBrianne – Mapping a lost branch of the Nile Alan – Interactive version of the updated USDA gardening zone map on NPR.
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin delves into discussing drinking “raw” milk possessing H5N1 influenza virus, if the virus can reproduce in the human gut, and the meaning of finding viral RNA in wastewater samples before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, withdrawal of AstraZeneca’s SARS-CoV-2 vaccine from the European market, discusses the emergency use application of a pre-exposure prophylactic, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of colchicine for the management of COVID-19, compares and provides information for the enrollment into the NIH clinical trials of long COVID and its effects on sleep, exercise intolerance and the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance and post-exertional malaise. For more information about cow and milk infection by H5N1 listen to the discussion with Richard Webby on TWiV 1113 and for long COVID-19 listen to TWiV 1088. Dr. Griffin also provides a list of apps for monitoring one’s health including brain health.
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Links for this episode * Who demands milk infected with H5N1? (Futurism) * Uncowed by milk possessing H5N1 (LA Times) * Cow flu flying around for 4 months (CNN) * The unpasteurized raw milk institute (Raw Milk Institute) * Infection and reproduction of H5N1 in the human gut (JID) * Wastewater samples identified H5N1 in 9 cities (medrxiv) * Richard Webby, is H5N1 a concern? (TWiV 1113) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Spring vaccineadvice (CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practices slides (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * Withdrawal of Astra-Zeneca SARS-CoV-2 vaccine in Europe (European Medicines Agency) * Astra-Zeneca withdraws SARS-CoV-2 vaccine from market (AP news) * Global vaccine data/adverse event network (Vaccine) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * Early phase of SARs-CoV-2 infection (COVID.gov) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (IDSociety) * Overuse ofantibiotics for COVID-19: a viral disease (European Society of Clinical Microbiology and Infectious Diseases) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) * Updated respiratory virus guidances (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Colchicine for managing COVID-19 (BMC Pulmonary Medicine) * Colchicine guidelines (ID Society) * Long COVID evidence based review TWiV shout out (TWiV 1088) * NIH long COVID sleep disturbance, exercise intolerance and post exertional malaise clinical trials (NIH News) * COVID-19 Yorkshire rehabilitation scale (BML Open Respiratory Research) * Visible heart monitor (Makevisible) * Bearable app (Bearable) * Tracking your chronic illness using Flaredown (Flaredown) * Improving your brain health (BrainHQ)Vanderbilt’s long COVID resources: podcasts and books (Vanderbilt University) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1114 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Richard Webby joins TWiV to review the history of avian H5N1 influenza virus, the recent change in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Richard Webby
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Webby research laboratory * H5N1 virus in dairy cattle and cats (Emerg Inf Dis) * Emergence of H5N1 virus in dairy cattle (bioRxiv) * Spillover potential of H9N2 bat virus (Nat Commun and TWiV 1111) * Letters read on TWiV 1113 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Little Researcher (from Bioss) Alan – Global Polio Eradication Initiative’s OPV switch was “unqualified failure.” Vincent – Errant Science
Listener Picks Moragh – Paper Cuts Podcast
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin deep dives into infections of dairy cattle with high pathogenic influenza H5N1, how long virus has been circulating and if known anti-influenza antivirals can reduce secondary attack rates, before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster takes associates with long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, if administration of oral antiviral therapies can prevent the onset of post-acute sequelae following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, compares and contrasts the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance following SARS-CoV-2 infection and the epidemiology of the pandemic in a Kenyan refugee camp. For more information about this body of work, listen to TWiV 1088.
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Links for this episode * Technical reports on high path avian influenza (CDC) * High path cow influenza H5N1 clade 2.3.4.4b (Emerging Infectious Diseases) * Cow flu flying around for 4 months (CNN) * Interstate commerce: high path avian influenza in dairy cattle (bioRxiv) * Oseltamivir and baloxavir marboxil treatment for influenza in household index cases (Influenza and other respiratory viruses) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Spring vaccine advice (CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practices slides (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (IDSociety) * Overuse ofantibiotics for COVID-19: a viral disease (European Soc Clin Micro Inf Dis) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) * Updated respiratory virus guidances (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Antiviral effect of metformin on SARS-CoV-2 viral load (CID) * Nirmatrelvir-ritonavir to prevent post-acute sequelae and mortality in SARS-CoV-2 hospitalized patients (Lancet Infectious Diseases) * Oral antivirals for acute and post-acute sequelae from SARS-CoV-2 infection (Lancet Infectious Diseases) * Nirmatrelvir-ritonavir for prevention of COVID-19 related hospitalization (American Journal of Therapeutics) * Nirmatrelvir-ritonavir effectiveness (American Therapeutics) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Cognitive profile in multiple sclerosis and post-COVID (Scientific reports) * Exercise intolerance in long COVID (American Journal of Medicine) * Epidemiology of SARS-CoV-2 in the Kakuma refugee camp, Kenya (Emergining Infectious Diseases) * Rohingya refugees (USA for UNHCR) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1112 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews viruses in the news: Chinese scientist who released the SARS-CoV-2 genome sequence sleeps in the street, a case of measles in Haifa, spread of waterborne infectious diseases in Gaza, interstate spread of avian influenza A(H5N1) in dairy cattle, and an orangutan heals himself with medicinal plants, followed by identification of a cell receptor for parechoviruses, and blockade of necroptosis prevents lung injury in severe influenza.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier (blog post) * International Conference on Pandemic Preparedness * Chinese virologist sleeps on street (Nature) * Measles in Haifa (Jerusalem Post) * Waterborne illness spreads in Gaza (Reuters) * Interstate spread of H5N1 virus in dairy cattle (bioRxiv) * Orangutan uses medicinal plants (Science) * Parechovirus cell receptor identified (Nat Comm) * Necroptosis blockade prevents lung injury in influenza (Nature) * Necroptosis, pyroptosis and apoptosis (Cell Mol Immunol) * Letters read on TWiV 1111 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – NASA’s Webb Finds Ethanol, Other Icy Ingredients for Worlds Alan – MyClimate.org calculators Vincent – Twenty-Five Lectures in Virology 2024
Listener Picks Alan – NPR story and interactive quiz on pandemic respiratory disease transmission Az – H5N1 Avian Flu in Mammals
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin begins with discussing if the antibiotic neomycin is really a pan-antiviral countermeasure, then reviews the recent statistics on SARS-CoV-2 infection before deep diving into if shedding and the rapid antigen test results correlate, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster associates with the long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, the caveats for improper use of antibiotics to treat SARS-CoV-2 (a viral infection), continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of an anti-immunoglobulin E monoclonal antibody can be used for COVID-19 treatment, if inhibiting T-cell activation will reduce secretion and production of inflammatory cytokines including IL-6, if changes in the gut microbiome associate with post -acute COVID-19 syndrome, and the pulmonary and neurologic determinants of long COVID-19 such as the presence of neurofilament light chain in plasma. For more information about this body of work, listen to TWiV 1088.
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Links for this episode * Intranasal antibiotic evokes antiviral response (PNAS) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * SARS-CoV-2 shedding vs rapid antigen test performance (MMWR) * Spring vaccineadvice (CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practices slides (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * COVID-19 booster take: cross-sectional study (Vaccine) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (IDSociety) * Overuse ofantibiotics for COVID-19: a viral disease (European Society of Clinical Microbiology and Infectious Diseases) * Can you believe that antibiotics are ineffective against a viral illness (NKT Institute) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) * Updated respiratory virus guidances (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Immunologic antiviral therapy with omalizumab (OFID) * Abatacept pharmacokinetics and exposure response (JAMA Network Open) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Gut microbiome and post-acute COVID-19 syndrome, ugh? (Cell Host and Microbe) * Pulmonary long COVID (JCI Insight) * Neurofilament light chain in long COVID019 neurocognitive symptoms (Molecular Psychiatry) * Contribute to our Floating Doctors fundraiser * Letters read on TWiV 1110 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews avian H5N1 influenza virus in the US, measles at highest levels in England, positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution, and cross-species spill-over potential of the H9N2 bat influenza A virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier (blog post) * International Conference on Pandemic Preparedness * Bird flu in humans (NY Times) * H5N1 genome sequences (USDA) * Measles cases and outbreaks (CDC) * Latest measles statistics (UK) * Positive selection underlies ORF8 loss (Nat Comm) * Spillover potential of bat H9N2 influenza virus (Nat Comm) * Letters read on TWiV 1109 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Journey to the Andromeda Galaxy, Highest jump in human history Alan – What Does a Scientist Look Like? photo gallery by Nature, and public display in London Vincent – The Campus-Left Occupation That Broke Higher Education, I’m a Columbia Professor. The Protests on my Campus are not Justice
Listener Picks David – Blue Angels unbelievable footage
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of remdesivir reduces mortality, long COVID, persistence of virus infection during long COVID and it prevalence. For more information about this body of work, listen to TWiV 1088.
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Links for this episode * Measles tracking (CDC) * Cows, chickens and birds H5N1….oh, my (USDA) * Evolution of circulating H5N1 (CIDRAP) * COVID-19 national trend (CDC) * COVID-19 deaths (CDC) * Original monovalent mRNA vaccine effectiveness in children and adolescents (MMWR) * Updated terminology for pathogens transmitted through the air (WHO) * Are these really better definitions for pathogens transmitted through the air (NY Times) * Pharmaceuticals for diseases spread through the air (Reuters) * Older adult spring booster available (CDC) * Advisory committee for immunization practices slides (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (IDSociety) * WHO vs national guidelines for COVID-19 therapeutics (BMJ) * COVID-19 and the bay of pigs (UNC) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) * Updated respiratory virus guidances (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Remdesivir associated with reduced mortality of hospitalized oxygenated patients (OFID) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Long COVID prevalence among adults (MMWR) * Persistence of SARS-CoV-2 infection (Lancet Infectious Diseases) * More questions, new answers long COVID (Lancet Infectious Diseases) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1108 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course).
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier (blog post) * International Conference on Pandemic Preparedness * Letters read on TWiV 1107 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Cats Are Perfect. An Evolutionary Biologist Explains Why Alan – Bardcore music by Hildegard von Blingin’ Vincent – A quote from Georgia O’Keefe: “I think it’s so foolish for people to want to be happy. Happy is so momentary – you’re happy for an instant and then you start thinking again. Interest is the most important thing in life; happiness is temporary, but interest is continuous”. From the dailyphilosopher
Listener Picks Julia – Recent success in troubleshooting autoclave challenges Charmaine – Viruses, myelin, the evolution of complex life, and the Fermi paradox
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, potential risk factors for severe disease following influenza infection before and SARS-CoV-2 circulation, before discussing if SARS-CoV-2 infection impacts sperm fertility, the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC,continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and long COVID. For more information about this body of work, For more information about this body of work, listen to TWiV 1088.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Measles tracking (CDC) * Influenza risk factors for potential severe outcomes (OFID) * COVID-19 national trend (CDC) * Does SARS-CoV-2 infection influence sperm quality (Scientific Reports) * Spring COVID-19 booster recommendations (CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practices slides (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * Slide 19 (CDC) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Infectious Disease Society guidelines for treatment and management (IDSociety) * Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM) * Nirmatrelvir/ritonavir vs. remdesivir for treatment of high risk outpatients (Therapeutic Advances in Infectious Disease) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio) * Updated respiratory virus guidances (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) Long COVID evidence based review TWiV shout out (TWiV 1088) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1106 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier (blog post) * Navigating the U.S. Immigration System webinar * International Conferene on Pandemic Preparedness * Avian influenza in dairy cows North Carolina and South Dakota * H5N1 clade 2.3.4.4 Pathogenic flu throughout NYC * Polio from Afghanistan to Pakistan extending public health emergency * CHAT GPT to combat vaccine hesitancy * Viral hepatitis worldwide * Dengue public health alert in Puerto Rico * Cherry trees being drowned by water level rise in DC * Paul in iron lung dies (NPR) * Hepatitis B virus in Eastern Eurasia (Nat Comm) * Antibody-independent protection against heterologous SARS-CoV-2 (Nature) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Do Other Planets Have Solar Eclipses? Kathy – Radcliffe Wave and Mt. Etna smoke rings with video Rich – Spongy Oak Apple Gall Wasp (Amphibolips confluenta) Life cycle; Gall formation Alan – Rogue attempt to clone giant sheep for captive hunting Vincent – The Scientists Rock. Literally.
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer’s phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to TWiV 1088.
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Links for this episode * Measles tracking (CDC) * Measles just this year (MMWR) * ABRYSVO phase 3 results (Pfizer) * RSV surveillance (CDC) * Influenza/flu surveillance (CDC) * Provisional deaths due to COVID-19 (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Rural-urban differences in COVID-19 mortality and hospitalizations (OFID) * Spring COVID-19 booster recommendations (CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM) * Assessment for clinical usefulness (NEJM) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Updated respiratory virus guidances (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Brian and cognitive changes in long COVID patients (BRAIN) * Allergic disease incidents after COVID-19 (Nat Comm) * Can post COVID patients exercise or do they have functional limitations (JAMA Network Open) * Contribute to our ASTMH fundraiser at PWB 37:06 * Letters read on TWiV 1102 37:56 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jason McLellan
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier * Prefusion-stabilized SARS-CoV-2 spikes (Science) * Structure-based vaccine design (Curr Opin Immunol) * Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm) * Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent’s comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to TWiV 1088.
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Links for this episode * Measles tracking (CDC) * What happens when measles is included in commercial syndromic PCR panels (MMWR) * Influenza/flu surveillance (CDC) * Influenza on the Texas ranch (Statnews) * Sequence analysis of highly pathogenic avian influenza from Texas (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * Can inflammatory cytokines and antibodies play nicely to prevent COVID-19 mortality (IJID) * Association of GLP-1RA and SGLT-2i to modulate COVID-19 severity (Diabetes Therapy) * Spring COVID-19 booster recommendations (CIDRAP) * Older adult spring booster available (CDC) * Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC) * EUA for pemgarda (FDA) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Remdesivir and cardiac adverse events in hospitalized patients (CID) * Long COVID evidence based review TWiV shout out (TWiV 1088) * Longitudinal study reveals long COVID symptom peaks and nadirs (OFID) * Paxlovid lowers risk of cardiovascular disease in COVID-19 patients with autoimmune disease (BMC Medicine) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1102 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Paul Offit joins TWiV to discuss his latest book, “Tell Me When It’s Over”, an insider’s guide to deciphering COVID myths and navigating our post-pandemic world.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guest: Paul Offit
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier * Tell Me When It’s Over by Paul Offit * Navigating the U.S. Immigration System (webinar) * Classifying Viral Subspecies (Workshop) * Options XII for the Control of Influenza (Meeting) * Letters read on TWiV 1101 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way’s Central Black Hole Brianne – Inside the AI Competition That Decoded an Ancient Herculaneum Scroll Vincent – biotech.symposium on Instagram
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the “oral remdesivir”, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children.
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Links for this episode * Measles tracking (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * What new monoclonal antibody therapy? (FDA) * A New pre-exposure prophylaxis for COVID-19? (Invivyd) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Really COVID-19 rebound after Nirmatrelvir-ritonavir treatment? (JAMA Network Open) * Can vaccines and antiviral be effective for COVID-19 together (International Journal of Infectious Diseases) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Can loss of infectivity among healthcare works with mild and recurrent COVID-19 be predicted (CID) * Household transmission dynamics in children with asymptomatic infection (CID) * Steroids,dexamethasone at the right time (OFID)Anticoagulation guidelines (hematology.org) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1098 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus.
Host: Vincent Racaniello
Guests: Volker Lohmann
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier * HCV human challenge studies (Lancet Gastro Hepatol) * Comparison of HCV and HAV infections (J Hepatol) * HCV cell culture systems (J Med Chem)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID.
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Links for this episode * Measles tracking (CDC) * Measles in Cook County (MMWR) * Gaps in measles vaccination drives viral surges (Infectious Disease Advisor) * Misinformation impacts public health? Seriously? (ID Society) * CDC alert for global and domestic measles cases and outbreaks (CDC) * Mpox in Kamituga associated with outbreak in DRB (Eurosurviellance) * Mpox in US, 2023 (MMWR) * Mpox in DRC, 2024 (reliefweb) * CDC guidance for respiratory diseases, COVID antiviral & emergence of clade I mpox (ID Society) * ~5% of infected dead from mpox (CIDRAP) * First cases of mpox in Republic of Congo (AP News) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * Multisystem inflammatory syndrome in children 2023 (MMWR) * Guidance for COVID-19 in children and adolescents (JPIDS) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Molnupiravir safety and efficacy (JMV) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * High/low oxygenation target (JAMA) * How much oxygen is needed (JAMA) * Orthostatic intolerance in long COVID and healthy volunteers (JMV) * Autonomic cardiac function in children and adolescents with long COVID (European Journal of Pediatrics) * Long COVID iron dysregulation and inflammatory stress erythropoiesis (Nat Imm) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1098 * Dr. Griffin's COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes.
Host: Vincent Racaniello
Guests: Sheree Yau and Victoria Queiroz
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier 8:16 * Virophage control of antarctic algal host-virus dynamics (PNAS) * Timestamps by Jolene. Thanks! * Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv) * Two groups of pithoviruses (J Virol) * Educational toolkit for virology classes (J Virol)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection.
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Links for this episode * Measles everywhere (CDC) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Estimating niresevimab effectiveness for infants (MMWR) * More than 100 children died of influenza (NBS News) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * Did the vaccine protect children against Long COVID (Pediatrics) * Did COVID-19 vaccination impact cardiovascular diseases? (Nat Comm) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Updated respiratory infection guidelines (CDC) * What do when your heathcare provider is infected with SARS-CoV-2 (CDC) * Managing healthcare staffing shortages (CDC) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID trial for autonomic nervous system dysfunction (NIH) * Nirmatrelvir-ritonavir impact on myocardial injury and long-term cardiovascular outcomes in COVID-19 hospitalized patients (Cardiovascular Drugs and Therapy) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1096 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier * Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis) * Continued circulation of oropouche virus (PAHO and WHO) * Herpesviruses in fur seals and sea lions (PLoS One) * Sex-specific effects of SARS-CoV-2 infection (PLoS One) * Drivers of 2022 Mpox virus epidemic (Cell) * How AAV gene transfer works (YouTube) * Humanized mouse model for AAV gene therapy (Nat Comm) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Baden Powell – Manha de Carneval Angela – Upcoming Health & Fitness podcast from MicrobeTV Rich – Mark Smith Photography Alan – OpenVertebrate (and Science article on it) Vincent – Veterinary apparel for the veterinary nerd
Listener Pick Anne – Why Reed Jobs is betting on cancer innovations
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * What to do when you are sick with a respiratory virus (CDC) * Basis for respiratory virus guidance (CDC) * Effectiveness of updated COVID-19 vaccines (MMWR) * CDC Quarantine guidelines (CDC) * NIH COVID-19 treatment guidelines (NIH) * Synergy or additive protection with vaccination and oral antivirals (CID) * To rebound or to not rebound (MMWR) * Know your COVID-19 tools (ESMED) * How to pay for Paxlovid (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Still talking about Ivermectin? (Journal of Infection) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Cognition and memory after COVID-19 (NEJM) * Loss of IQ after SARS-CoV-2 infection (CIDRAP) * Really, more evidence for long COVID and impaired cognition (NEJM) * Memory assessment before and after COVID-19 (NEJM) * Please complete this memory questionnaire (Community hyperbaric) * Impact of long-term COVID-19 on workers in healthcare settings (PLoS One) * Healthcare workers have difficulty assessing long COVID (CIDRAP) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1094 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses effectiveness of this season’s flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * The New City by Dickson Despommier * Effectiveness of flu vaccine (MMWR, Eurosurveill) * Efficacy of Pfizer RSV vaccine (Pfizer) * Understanding six types of vaccine technologies (Pfizer) * nOPV in US? (CDC) * Dengue in Peru (Peruvian State) * Measles in Michigan and Indiana * Marburg virus control by reservoir bats (Nat Commun) * tRNA acquisition by phages (Cell) * Viruses of Microbes 2024 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The reappearance of Lake Manly Kathy – “Practical Playbook for Addressing Health Misinformation” Rich – Making It So: A Memoir by Patrick Stewart Jolene – Thinking Like a Phage by Merry Youle Vincent – The Science of Leap Year
Listener Picks Blog design – Anthony Fauci will reflect on his long government career in ‘On Call,’ to be published in June Peter – Republican warns of vaccines being slipped into vegetables: ‘A polio vaccine in there’
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition.
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Links for this episode * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * RSV vaccination stats (CIDRAP) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * ACIP COVID vaccination for seniors recommendations (CIDRAP) * Additional vaccine doses for older adults (CDC) * Evidence based advice from the ACIP (CDC) * State mandates did NOT influence primary vaccination rates only boosters (PNAS) * No nOPV2? (CDC) * CDC Quarantine guidelines (CDC) * To rebound or to not rebound (MMWR) * Know your COVID-19 tools (ESMED) * How to pay for Paxlovid (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Molunpiravir plus antibody therapy for at-risk outpatients (Nat Comm) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Spontaneous release of IFN-g in Long COVID (Science Advances) * Blood-brain-barrier compromise in long COVID associated cognitive impairment (Nat Neuroscience) * Persistent community SARS-CoV-2 RNA (Nature) * Hyberbaric oxygen therapy improves post COVID neurocognition (Scientific Reports) * Medical study questionnaire, the SHORT form (Brandeis) * Long term effects of hyperbaric oxygen post COVID (Scientific Reports) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1092 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Viruses of Microbes 2024 * Resurgence of Lassa fever (Science) * cVDPV2 in Zimbabwe (UNICEF) * CWD from eating plants (CIDRAP) * Measles in New Orleans (LA Dept Health) * SARS-CoV-2 persistent infections (Nature) * Leaky BBB for brain fog of long COVID (Nat Neurosci) * Measles in Broward County FL (7 News) * Failure of FL Surgeon General to support vaccination (X) * Measles variant (Eurosurveillance) * West Nile virus transmitted among mosquitos by excreta (bioRxiv) * Mosquito life cycle (YouTube) * Viroid-like colonists of human microbiomes (bioRxiv) * Letters read on TWiV 1091 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Sustainable energy in America 2024 factbook Kathy – Life Magnified USPS stamps Rich – “How plants communicate with each other when in danger” by Kasha Patel (Original Nature Communications article) Alan – A Sargasso Sea of Space card game. Vincent – Tell Me When It’s Over by Paul Offit
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week’s influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax rapid diagnostic tests for SARS-CoV-2 infection, if N95 masks need a yearly fitting, how SARS-CoV-2 vaccination impacts the prevalence of long COVID, reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, why determining the exact number of long COVID incidences is challenging, how the incidence and predictors for fatiguing illness following SARS-CoV-2 infection may used to reenforce the need for public health actions to prevent virus infection and the risks of respiratory pathologies including lung cancer associate with SARS-C0V-2 infection.
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Links for this episode * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * RSV vaccination stats (CIDRAP) * Abrysvo vaccine stats (Axios) * RSV vaccination dashboard (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * Who is more accurate the clinician or the self for BinaxNow rapid testing (ASM Spectrum) * Annual N95 fitting (Infection Control and Hospital Epidemiology) * How vaccination impacts long COVID prevalence (Annals of Epidemiology) * CDC Quarantine guidelines (CDC) * To rebound or to not rebound (MMWR) * Know your COVID-19 tools (ESMED) * How to pay for Paxlovid (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Long COVID in adults (MMWR) * Estimating and predicting fatiguing illness after SARS-CoV-2 infection (EIS) * Long term risks of respiratory disease following SARS-CoV-2 infection (eClinical Medicine) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1080 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Viruses of Microbes 2024 * Fatal case of Alaskapox (AK Beacon) * MERS in Kenya (Emerg Inf Dis) * Diagnostic tests for Nipah and Lassa (CEPI) * Measles in Arizona and Minnesota * HCV-derived circular RNAs (PNAS) * Resident memory CD8 T cells prevent respiratory virus transmission (Nature) * Letters read on TWiV 1089 1:24:33 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Visualizing Science: Illustration and Beyond Brianne – Vaccination from the Misinformation Virus and Invisible Corps Alan – Preventing needlephobia in kids Vincent – Two new Djs I discovered Rosana Nun and Sunset Cartel
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK’s RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the CDC or WHO definition of long COVID is beneficial or the use of directed questions, baselines test and listening to the patient tell their story are beneficial in making a long COVID diagnosis.
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Links for this episode * Nirsevimab immunoprophylaxis to prevent RSV hospitalization (Eurosurveillance.) * Arexvy given Priority Review in US for the prevention of RSV disease in adults aged 50-59 (GSK) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Can antibodies be redirected from egg adapted epitopes using recombinant or cell cultured based influenza vaccines (Nat) * Can influenza infection lead to cardiovascular events (JID) * Risk of death after chikungunya infection and disease (Lancet) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * Alternative intervals between vaccine doses (Nat Comm) * Early mortality after first vaccination dose (CID) * CDC Quarantine guidelines (CDC) * To rebound or to not rebound (MMWR) * Know your COVID-19 tools (ESMED) * How to pay for Paxlovid (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Burnout compassion fatigue Long COVID (OFID) * Scoring PASC (JAMA) * What is your definition of the Long COVID (WHO) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1088 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Viruses of Microbes 2024 * Infant rhinovirus bronchiolitis contribution to hospital bed and vent use (JAMA Net Open) * Onradivir new influenza antiviral (Lancet) * Oropouche fever in Brazil (PAHO) * Maryland and Ohio measles * Repealing school vaccination exemptions (JAMA New Open) * Increases risk of FMDV entry into Europe (pig333) * Severe primary and secondary dengue (Nat Med) * Mitigation of measles immune amnesia and exacerbated disease (Nat Comm) * Letters read on TWiV 1087 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – For Your Processing Pleasure: The Sharpest Pictures of Jupiter’s Volcanic Moon Io in a Generation Angela – Whale Scientists Rich – Benefit-risk assessment of vaccines; The Brighton collaboration standardized module for vaccine benefit-risk assessment; Vaccine adverse events: causal or coincidental?; Austin area Singing Valentines Vincent – International Day of Women and Girls in Science, 11 February
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one’s sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infection.
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Links for this episode * Do you want a job in healthcare? (JAMA) * Why people don’t tell the truth about infectious diseases (Psychological Science) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * Is susceptibility and severity of COVID-19 inheritabile (Nat Comm) * Neonates of vaccinated mothers (JAMA) * How is the monovalent XBB.1.5 vaccine effectiveness against symptomatic infection Sept 2023-Jan 2024 (MMWR) * Second dose in the opposite arm improves antibody response (JCI) * Virus specific immune repsonses following contralateral or ipsilateral immunication (eBioMedicine) * CDC Quarantine guidelines (CDC) * To rebound or to not rebound (MMWR) * Know your COVID-19 tools (ESMED) * How to pay for Paxlovid (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * How COVID-19 affected your sleep (Frontiers in Public Health) * Health and economic burden of COVID-19 after illness (BMC Medicine) * Predicting recovery from fatigue and cognitive deficits after COVID-19 (eClinical Medicine) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1086 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection.
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Viruses of Microbes 2024 * Pig virus imperils food security in Borneo (Science) * Measles outbreaks in UK and Europe (Nature) * Fatal Nipah virus infections in Bangladesh (CIDRAP) * Yellow fever outbreak in Sudan (Crisis24) * COVID-19 influenced by type of immunodeficiency (Sci Transl Med) * Intestinal microbiota programming of alveolar macrophages (Cell Host Microbe) * Letters read on TWiV 1085 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – JWST details of 19 spiral galactic centers Rich – Great White Shark Attack And Breach Vincent – Black History Month and Lost Photographs of Black America
Listener Picks Louise – The Mystery Of The Village That Beat The Black Death Pierre – Three things airlines don’t want you to know Brandon – Professor Dave explains
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses the safety of the prefusion RSV vaccine, if high or moderate dose of the quadrivalent influenza vaccine is better for protection against hospitalization, summarizes the new WHO COVID guidelines, revisits how to prevent pathogen transmission in healthcare setting, the under use of COVID oral antiviral and what occurs in persistently SARS-CoV-2 infected cells in culture after antiviral treatment, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how inflammatory markers change correlate with death when in ICU and if cognitive slowing is part of long COVID-19.
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Links for this episode * Do you want a job in healthcare? (JAMA) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Efficacy and safety of RSV vaccine after 2 seasons (CID) * High vs moderate dose of quadrivalent influenza vaccine (CMI) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * WHO COVID guidance (WHO) * Thoughts on COVID guidance (CIDRAP) * Update on how to prevent pathogen transmission in healthcare settings (CDC) * Underuse of antiviral drugs against COVID-19 (MMWR) * Revisiting tissue culture cells persistently infected following antiviral therapy (bioRxiv) * To rebound or to not rebound (MMWR) * Know your COVID-19 tools (ESMED) * How to pay for Paxlovid (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Changes in inflammatory markers and death correlation when in ICU (Cytokine) * Long COVID & cognitive slowing? (eClinicalMedicine) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1084 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Jay Nelson obituary * Measles outbreak in Europe and Central Asia (UNICEF) * Closing the toilet lid doesn’t reduce virus aerosols (Am J Inf Control) * NASA’s ingenuity helicopter mission ends (NASA) * HPV vaccine prevents invasive cervical cancer (J NCI) * Designing AAV vectors with machine learning (Sci Adv) * Letters read on TWiV 1083 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Asian girl building a life building a fence to protect a bamboo house Rich – Gator Country: Deception, Danger, and Alligators in the Everglades by Rebecca Renner Alan – Strange Bedfellows, by Ina Park Vincent – Star and Sphere kit – try the main page too
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, before discussing viral transmission to adults in healthcare setting, the recently EUA approved protein based COBREVAX vaccine, reviews quarantine guidelines, the use of simnotrelivr for mild to moderate COVID-19, how viral RNA may persist in your cell culture dish following antiviral therapy, continues to dispel the myth of viral rebound, how to pay for Paxlovid, , when to use steroids and the benefits of convalescent plasma, how Paxlovid may prevent long COVID and how complement dysfunction may lead to thromboinflammation during long COVID.
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Links for this episode * Articles and graphs cited in TWIV CU 1080 * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Variant hospital admissions (CDC) * Transmission in healthcare setting (CID) * COBREVAX EUA (Texas Children’s Hospital) * Quarantine/isolation guidelines (CDC) * Simnotrelvir for mild to moderate disease in adults (NEJM) * Are your tissue culture cells persistently infected following antiviral therapy (bioRxiv) * Structural biology of antivirals for SARS-CoV-2 (Signal Tranduction and Targeted Therapy) * To rebound or to not rebound (MMWR) * Know your COVID-19 tools (ESMED) * How to pay for Paxlovid (PAXCESS) * Remdesivir for immunocompromised during variant waves (CID) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Patients, experts, Congress…..long COVID oh my! (CIDRAP) * Does paxlovid prevent long COVID? (CIDRAP) Persistent complement with thromboinflammation in long COVID (Science) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV 1082 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Midwife gave children pellets instead of vaccines (NY Times) * Vaccine derived poliovirus circulation in Indonesia (WHO) * 9th case of measles in Philadelphia (City of Philadelphia) * Measles exposure warning northern Virginia (Virginia DOH) * China lab sequenced SARS-CoV-2 genome 2 weeks before release (WSJ) * Wisconsin bill to restrict gain of function experiments (Science) * Virus infection of insects causes long wings (PNAS) * Reverse zoonoses of influenza H1N1 virus in swine (PLoS Path) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Concerto for Horn and Hardart, P. Schickele Angela – ChatGPT4 Brianne – How mRNA Vaccine Works, Why We Need Two Doses of mRNA Vaccine Rich – Evolutionary basis for the human diet: consequences for human health by P. Andrews, R.J. Johnson Vincent – Virology Lectures 2024
Listener Picks Geoff and Anonymous – Dickson Despommier wants our cities to be like forests
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing vaccine effectiveness in children and adolescents, how the pandemic impacted the socioemotional development of infants and toddlers, continues to dispel the myth of viral rebound, how to pay for Paxlovid, reviews quarantine guidelines, when to use steroids and the benefits of convalescent plasma, examines the role of immune aberrations in long COVID and how vaccination may protect against developing long COVID.
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Links for this episode * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend(CDC) * COVID-19 wastewater testing (biobot) * Variant tracker (CDC) * Remember when COVID was bad? (Wired) * Children and adolescents hospitalized with SARI (Pediatrics) * COVID-19 vaccines are effective for adolescents (Pediatrics) * Vaccine effectiveness against long COVID in children (Pediatrics) * Infant and toddler socioemotional development in the pandemic (JAMA) * Quarantine/isolation guidelines (CDC) * Should I take Paxlovid? (NY Times) * What is this about Paxlovid rebound? (CDC) * Rebound is NOT the early inflammatory phase (ESMED) * How to pay for Paxlovid (PAXCESS) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma recommendation for immunocompromised (IDSociety) * Steroids,dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * T cell dysregulation inflammation and uncoordinated adaptive immune response, Long COVID oh my (Nat Imm) * Vaccine effectiveness against long COVID (CIDRAP) * Prevention of long COVID by vaccines (Antimicrobial-stewardship and healthcare) * Sex and gender relationship with long COVID (Eurosurveillance) * Are all vaccines equal in preventing Long COVID? (Lancet) * Vaccine naïve individuals, Long COVID and vaccination (medRxiv) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV 1080 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update, Dr. Griffin reviews recent measles outbreaks, prequalification of nOPV2 by the WHO and most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US before discussing COVID-19 deaths linked to SNPs in C-reactive protein, spread of recent viral variants, how early vaccination reduced hospitalization of those infected with XBB.1.5, reviewed quarantine guidelines, how oral antivirals reduce hospitalizations, dissociation of antiviral treatment from infection rebound, and long COVID, deaths due to administration of hydroxychloroquine, muscle abnormalities and extreme fatigue in individuals with long COVID-19 and how the economics of where you live make long COVID-19 more severe.
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Links for this episode * A national measles campaign (CDC) * A nation of measles (CDC) * The measles unvaccinated in NY (CNN) * Philadelphia’s measles story (Phila gov) * January’s measles outbreak (CNN) * Prequalify of nOPV2 by WHO (GPEI) * Did you prequalify for the novel poliovirus vaccine (CIDRAP) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend(CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Death rate and C-reactive protein SNPs and COVID-19 (Scientific Reports) * Variant tracker (CDC) * Tracking variant hospitalizations (CDC) * Early vaccination against XBB.1.5 hospitalization (Eurosurveillance) * Vaccination dashboard (Netherlands) * Quarantine/isolation guidelines (CDC) * Antiviral gap among the non-hospitalized high risk adults (CID) * Oral antivirals prevent hospitalization (medRxiv) * Rebound with and without oral antivirals (MMWR) * Randomized rebound trials (MMWR) * Know your COVID-19 tools (ESMED) * The PASC-paxlovid relationship (JAMA) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma remmendation for immunocompromised (IDSociety) * Fluvoxamine for COVID-19 outpatient (RMV) * Death by hydroxychloroquine (Biomedicine & Pharmacotherapy) * Steroids, dexamethasone at the right time (OFID) * Anticoagulation guidelines (hematology.org) * Doxycycline for prevention of progression of COVID-19 (PLoS One) * Muscle abnormalities in long COVID (Nat Comm) * Discovery of persistent fatigue in long COVID-19 (Amsterdam Univ Med Crr) * IMPACC study post-acute sequelae results (Nat Comm) * Double course of long COVID in low income countries (Nat) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV 1078 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Global dengue cases rise markedly (WHO) * Measles outbreak in Philadelphia (Phil Health Dept) * Viruses and organomineralization of travertine (Sci Rep) * Neutralizing antibodies and clearance of HCV infection (Immunity) * Letters read on TWiV 1079 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Global climate highlights 2023 and 7 new songs you should hear Brianne – Stuff you should know episodes: METI and SETI Kathy – Oppenheimer “Science, Mission, Legacy” documentaries from Los Alamos Lab One Two Three and Los Alamos National Laboratory Summer 2023 National Security Science: The Oppenheimer Issue Rich – The Wager: A Tale of Shipwreck, Mutiny and Murder by David Grann Alan – Less is Morse, an educational game Vincent – Citing Misinformation, Florida Health Official Calls for Halt to Covid Vaccines
Listener Picks Sonrisa – Microorganisms in Perspective Anonymous – Wow! Human Cells Vibrate With Resonant Frequency and It’s Technically Audible
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent travels to McGill University in Montreal, Canada to join Angela for a discussion of the careers and the research of two faculty members, Corinne Maurice and Jesse Shapiro, and their PhD trainees Anshul Sinha and Sana Naderi.
Hosts: Vincent Racaniello and Angela Mingarelli
Guests: Corinne Maurice, Jesse Shapiro, Anshul Sinha and Sana Naderi
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Phage and colitis (Microbiome) * Origins and evolution of Lassa virus (Cell) * Phage replication in human gut microbiota (iScience) * Phages in infant gut (ISME J) * Early SARS-CoV-2 transmissions in Quebec (Genome Med) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin highlights global circulation of Mpox virus, reviews the most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, and discusses the clinical outcome of hospitalized children under 5 years infected with SARS-CoV-2, the perinatal and neonatal outcomes including adverse effects of SARS-CoV-2 infection and virus transmission in Italy between early 2020 and 2022, the guidelines to improve home ventilation, the safety and efficacy of the oral anti-viral molnupiravir and the use of convalescent plasma as a long term treatment as well as treatment specifically for the immune compromised, the ineffectiveness of antibiotics for treating COVID-19, the association of olfactory dysfunction and the administration of corticosteroids and the safety of the RSV vaccines licensed last year.
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Links for this episode * Articles and graphs cited in TWIV CU 1076 * Global mpox circulation (WHO) * Mpox in the Americas and Europe (CIDRAP) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Influenza/flu surveillance (CDC) * Influenza/flu map (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * Vaccine-Eligible Children Under-5 Years (PIDJ) * Pre-school cohort vaccination rate (CIDRAP) * Perinatal transmission and neonatal outcomes (IJID) * Adverse maternal and neonatal effect (dgalerts) * Ventilation home improvements (CDC) * Quarantine/isolation guidelines (CDC) * Molnupiravir safety and efficacy (JMV) * Convalescent plasma remmendation for immunocompromised (IDSociety) * Corticosteroids in SARS-CoV-2 * Anticoagulation guidelines (hematology.org) * Corticosteroids induced olfactory dysfunction (PLoS One) * Convalescent Plasma Therapy: Long Term Implications (OFID) * Preventing RSV infection by vaccination (MMWR) * Antivirals and chronic kidney disease (CID) Early administraton of molnupiravir versus ritonavir-boosted nirmatrelvir (Lancet Infectious Diseases) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV 1076 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek’s disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, Brianne Barker and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Ancient chickens and Marek’s disease virus (Science) * Diversity and dissemination of Leishmania virus and L. braziliensis (Nat Comm) * Letters read on TWiV 1074 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Addictive Mandelbrot video and Gore slams COP28 summit Angela – 10 top-trending health questions you had for Dr. Google in 2023 Brianne – Tomato lost in space has been found Kathy – Earthquakes of the 20th Century Vincent – Animator Chris Georgenes especially Tricycle animation study
Listener Picks Jason – Spot-on, quick booster explainer and “Inverse” vaccine Slashdot’s summary. the full article, primary research article Meika – Iceland earthquake site
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the outcomes of SARS-CoV-2, influenza and respiratory syncytial virus infection in pediatric communities under the age of 18 years, the treatment of infants with the human monoclonal anti-respiratory syncytial virus antibody to prevent hospitalizations, most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, how the SARS-CoV-2/COVID-19 pandemic affected school attendance and child healthcare, how exposure length influenced transmission of SARS-CoV-2, how the durability of the anti-SARS-CoV-2 antibody response to protect against virus re-infection, if administration of oral antiviral therapy affected viral rebound in either the unvaccinated or vaccinated populations, as well as a reminder of the ineffectiveness of antibiotics for treating COVID-19 and the effect of vaccination on post-COVID conditions in children between 5-17 years old.
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Links for this episode * Pediatric outcomes SARS-CoV-2, flu, RSV (JAMA Peds.) * SARS-CoV-2 vs Flu (Wired) * Anti-RSV antibody treatment for infants (NEJM) * Respiratory disease surveillance (CDC) * RSV surveillance (CDC) * RSV national trend (CDC) * Influenza/flu surveillance (CDC) * COVID-19 hospital admissions (CDC) * COVID-19 national trend (CDC) * COVID-19 wastewater testing (biobot) * COVID-19 school attendance (JPEIDS) * COVID-19 pandemic effects children health care (JPEIDS) * Digitally measuring transmission (Nat) * Antibody titers and re-infection (CMI) * Oral antiviral and SARS-CoV-2 rebound (MMWR) * Rebound after antiviral controlled trial (MMWR) * Vaccination and antiviral therapy (OFID) * Antivirals and hospitalization (JMV) * Antivirals molnupiravir (JMV) * Convalescent plasma and the immunocompromised guidelines (IDSOciety) * Steroid and the cytokine storm (OFID) * Anticoagulation guidelines (hematology.org) * Unnecessary antibiotics (NEJM) * Vaccination and long COVID (OFID) * RSV vaccination (MMWR) * Antivirals and chronic kidney disease (CID) * Early administraton of molnupiravir versus ritonavir-boosted nirmatrelvir (Lancet) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV 1074 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Become a member of ASV (asv.org) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Brett Lindenbach passes (Yale Medicine) * Virome of small mammals (Cell) * Epstein-Barr virus nanoparticle vaccine (Cell Host Micr) * Letters read on TWiV 1073 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Summary of Global Climate Action at COP 28 and Notable Deaths 2023: Music Kathy – Two APODS Winter solstice, 183 Days in the Sun and the Same color illusion Vincent – The American Academy of Microbiology discusses gain-of-function research of concern (GOFROC) and enhanced potential pandemic pathogens (ePPP)
Listener Picks Gregory – Climate Change – A revised prediction – Steven Chu John – Detergent packs are kinda wishy-washy (Technology Connections)
Intro music is by Ronald Jenkees
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In his weekly clinical update Dr. Griffin discusses the annual economic burden of respiratory syncytial virus in adults in the US, recombinant or standard-dose influenza vaccine in adults under 65 years of age, maternal vaccine effectiveness against influenza-associated hospitalizations and emergency department visits in iInfants, influenza positive tests reported to CDC by US clinical laboratories, update on COVID-19, risk of severe maternal morbidity associated with SARS-CoV-2 infection during pregnancy, COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens, optimal timing of nirmatrelvir/ritonavir treatment after COVID-19 symptom onset or diagnosis: target trial emulation, long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study, and risk of arrhythmias following COVID-19: nationwide self-controlled case series and matched cohort study.
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Links for this episode * RSV economic burden, US (J Inf Dis) * Recombinant or standard dose influenza vaccine (NEJM) * Maternal vaccine effectiveness against influenza in Infants (JAMA Ped) * Weekly influenza surveillance report (MMWR) * COVID data tracker (hospital admissions, national trend) * Risk of severe maternal morbidity associated with SARS-CoV-2 infection (J Inf Dis) * COVID-19 rapid antigen tests with nasal and throat swab specimens (JAMA Net Open) * Optimal timing of nirmatrelvir/ritonavir (Nat Comm) * Long-term outcomes following hospital admission for COVID-19 vs influenza (Lancet) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV 1072 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent visits the Max Planck Institute for Medical Research in Heidelberg, Germany to speak with Matthias Fischer about his career and his research on giant viruses, virophages, and their protist hosts.
Host: Vincent Racaniello
Guest: Matthias Fischer
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * C. roenbergensis giant virus (PNAS) * Virophage at origin of large DNA transposons (Science) * Host genome integration and giant virus-induced reactivation of virophage mavirus (Nature) * Invasion of protist genomes by DNA viruses (PNAS) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses monkeypox and chickenpox co-infection in southern Nigeria, vaccine effectiveness against influenza A, SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk, COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens, four methods for monitoring SARS-CoV-2 and Influenza A virus activity in schools, efficacy and safety of Baricitinib for the treatment of hospitalized adults with COVID-19, a synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong, consistent absence of cerebrospinal fluid biomarker abnormalities in patients with neurocognitive post-COVID complications, and risk of new-onset long COVID following reinfection with SARS-CoV-2.
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Links for this episode * Monkeypox and chickenpox co-infection in southern Nigeria (JID) * Vaccine effectiveness against influenza A (CID) * SARS-CoV-2 neutralizing antibody titers in maternal blood, umbilical cord blood, and breast milk (JOP) * COVID-19 rapid antigen tests with self-collected vs health care worker–collected nasal and throat swab specimens (JAMA) * Four methods for monitoring SARS-CoV-2 and influenza A virus activity in schools (JAMA) * Efficacy and safety of Baricitinib for the treatment of hospitalized adults with COVID-19 (EJMR) * A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (The Lancet) * Consistent absence of cerebrospinal fluid biomarker abnormalities in patients with neurocognitive post-COVID complications (JID) * Risk of new-onset long COVID following reinfection with SARS-CoV-2 (OFID) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control.
Hosts: Vincent Racaniello and Heli Harvala
Guest: Eeva Broberg
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Global Scholar Travel Awards (ASV) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * European Centre for Disease Prevention and Control * Emerging echovirus 30 in Europe (Emerg Inf Dis) * RSV surveillance (Eur Resp J) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses developmental impairment in children exposed during pregnancy to maternal SARS-COV2, vagus nerve dysfunction in the post-COVID-19 condition, and humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases, incidence and burden of long COVID in Africa.
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Links for this episode * Developmental impairment in children exposed during pregnancy to maternal SARS-COV2 (IJID) * Vagus nerve dysfunction in the post-COVID-19 condition (CMI) * Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in those with rheumatic diseases (STM) * Incidence and burden of long COVID in Africa (Nature) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
On this all-bacteriophage episode, TWiV explains the ‘vampire phage’, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Jolene Ramsey
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Global Scholar Travel Awards (ASV) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Gerd Sutter passes (LMU) * Avian influenza A (H5N1) Cambodia (WHO) * CWD expands in Montana (CIDRAP) * National Wastewater Surveillance System (CDC) * Vampire phage paper (ISME J) * UMBC phage hunters (UBMC) * Vampire viruses prey on other viruses (Conversation) * Phage internalized by mammalian cells (PLoS Biol) * Phage uptake by mammalian cells (iScience) * Phage-mammalian cell interactions (Ann Rev Virol) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Biden skips climate summit (NY Times) Rich – Lilium electric VTOL jet Alan – The Far Land, by Brandon Presser Jolene – Bacteriophage T4 infection watercolor painting by David Goodsell Vincent – Using narratives and storytelling to communicate science with nonexpert audiences
Listener Picks Darach – It depends t-shirt
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses a microbiologist who was harassed during COVID pandemic sues university, use of inactivated poliovirus vaccine for poliovirus outbreak response, safety and immunogenicity of bivalent rsvpref vaccine coadministered with seasonal inactivated influenza vaccine in older adults, coffee as a dietary strategy to prevent SARS-CoV-2 infection, enrollment of pediatric patients in COVID-19 interventional trials, vaccination, immunity, and the changing impact of COVID-19 on infant health, COVID-19 vaccine effectiveness against post- COVID -19 condition among 589722 individuals in Sweden, repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting, protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or hybrid immunity against Omicron-associated severe outcomes among community-dwelling adults, the Novavax heterologous COVID booster demonstrates lower reactogenicity than mRNA vaccines, T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19, oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China, and how COVID-19 convalescent plasma therapy decreases inflammatory cytokines, therapeutic heparin in non-ICU patients hospitalized for COVID-19 in the ACTIV-4a trial.
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Links for this episode * Microbiologist who was harassed during COVID pandemic sues university (Nature) * Use of inactivated poliovirus vaccine for outbreak response (The Lancet) * Safety and immunogenicity of bivalent RSVpreF vaccine coadministered with Influenza vaccine (CID) * Coffee as a dietary strategy to prevent SARS-CoV-2 infection (BMC) * Enrollment of pediatric patients in COVID-19 interventional trials (JAMA) * Vaccination, immunity, and the changing impact of COVID-19 on infant health (PNAS) * COVID-19 vaccine effectiveness against post- COVID -19 condition (BMJ) * Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting (Nature) * Protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or hybrid immunity against Omicron-associated severe outcomes (CID) * Novavax heterologous COVID booster demonstrates lower reactogenicity than mRNA (JID) * T-cell responses to SARS-CoV-2 infection and vaccination reduce risk of severe COVID-19 (STM) * Oral VV116 vs placebo in patients with mild-to-moderate COVID-19 in China (The Lancet) * COVID-19 convalescent plasma therapy decreases inflammatory cytokines (MS) * Therapeutic heparin in non-ICU patients hospitalized for COVID-19 in the ACTIV-4a trial (Chest) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV on TWiV 1066 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Global Scholar Travel Awards (ASV) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * House approves ban on gain-of-function research (Science) * Virology under the microscope (J Virol) * CWD detected in another Tennessee county (CIDRAP) * Polio eradication: Do no harm (Science) * nOPV2 causes polio (MMWR) * How is nOPV2 doing? (Polioeradication.org) * Feline infectious peritonitis caused by recombinant coronavirus (bioRxiv) * New feline coronavirus kills thousands of cats (Science) * Feline coronavirus with Gary Whittaker (TWiV 963) * Letters read on TWiV 1065 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Climate Action and How to find joy in climate action Brianne – A Virus that Generates Electricity Kathy – Intolerable Genius: Berkeley’s most controversial Nobel laureate Rich – Programmed DNA Elimination (PDE): Quanta; Current Biology Alan – KBDfans mechanical keyboard kits Vincent – The Covid Vaccine Windfall Turns for Pfizer and Moderna
Listener Picks Meika – Iceland Eruption or not?
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-suppressive drugs, symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to propensity score matched untreated individuals, late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial, higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19, recombinant C1 inhibitor in the prevention of severe COVID-19, and Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with asymptomatic or mild SARS-CoV-2 disease course.
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Links for this episode * Progress toward measles elimination (CDC) * Risk of severe COVID-19 despite vaccination in patients using immune-suppressive drugs (TID) * Symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to untreated individuals (CID) * Late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial (JID) * Higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19 (JAMA) * Recombinant C1 inhibitor in the prevention of severe COVID-19 (FII) * Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with SARS-CoV-2 disease course (BMC) * Contribute to our MicrobeTV fundraiser at PWB 37:55 * Letters read on TWiV on TWiV 1062 38:16 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other diseases.
Host: Vincent Racaniello
Guest: Kevin Messacar
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Global Scholar Travel Awards (ASV) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Emergence of EV-D68 (Microbio Spectr) * 2014 outbreak of EV-D68 (J Med Virol) * EV-D68 shedding in households (Emerg Inf Dis) * EV-A71 outbreak in Colorado (Lancet Inf Dis)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-19, mRNA SARS-CoV-2 vaccination before vs during pregnancy and omicron infection among infants, extracting symptoms from free-text responses using ChatGPT among COVID-19 cases in Hong Kong, SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy, optimization of antiviral therapy in immunocompromised COVID-19 patients, a study to learn about the study medicines (nirmatrelvir plus ritonavir) in people aged 12 years or older with COVID-19 and a compromised immune system, evaluation of the safety profile and therapeutic efficacy of Remdesivir in children with SARS-CoV-2 infection, effect of neutralizing monoclonal antibody treatment on early trajectories of virologic and immunologic biomarkers in patients hospitalized with COVID-19, and SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy.
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Links for this episode * Coverage with selected vaccines and exemption from school vaccine requirements among (CDC) * Seasonality of endemic COVID-19 (Virology) * mRNA SARS-CoV-2 vaccination before vs during pregnancy and Omicron infection among infants (JAMA) * Extracting symptoms from responses using ChatGPT among COVID-19 cases (CMI) * SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy (AIM) * Optimization of antiviral therapy in immunocompromised COVID-19 patients (ClinicalTrials) * A study to learn about nirmatrelvir/ritonavir in people with COVID-19 and a compromised immune system (ClinicalTrials) * Evaluation of the safety profile and therapeutic efficacy of remdesivir in children with SARS-CoV-2 infection (EJP) * Effect of neutralizing monoclonal antibody treatment on virologic and immunologic biomarkers in patients with COVID-19 (JID) * SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy (AIM) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV on TWiV 1062 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Global Scholar Travel Awards (ASV) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * The New City by Dickson Despommier * Seasonality of endemic COVID-19 (mBio) * Diversity of non-vaccine targeted HPVs (Cell Host Microbe) * Wart’s up doc? (TWiV 126) * Letters read on TWiV 1061 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – 2023 expected to be hottest year on record after warmest October ever Kathy – You can see the ISS toolbag with binoculars, Billy Collins wikipedia, What dogs think (probably) Alan – Landmark case to get sanitation declared a civil right Vincent – SciComm Studios
Listener Picks Charmaine – Petition fo National Science Appreciation Day Peter – Let’s eradicate polio this winter
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses stress in America 2023, CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with delta or omicron variants, masks during pandemics caused by respiratory pathogens, behavioral factors and SARS-CoV-2 transmission heterogeneity within a household cohort in Costa Rica, convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients, and olfactory and gustatory function 3 years after mild COVID-19.
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Links for this episode * Stress in America 2023 (APA) * CDC expands testing of international air traveler samples to include flu RSV, and other respiratory viruses (CDC) * Missed opportunities for preventing congenital syphilis (CDC) * Intrinsic and effective severity of COVID-19 case infected with BA.2 variant (JID) * Masks during pandemics caused by respiratory pathogens (JAMA) * Behavioral factors and SARS-CoV-2 transmission within a household cohort (Nature) * Convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients (NEJM) * Olfactory and gustatory function 3 years after mild COVID-19 (JAMA) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV on TWiV 1060 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and others that inhibit Ebolavirus spread from cell to cell.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Global Scholar Travel Awards (ASV) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Monoclonal antibody neutralizes all three poliovirus serotypes (Nat Comm) * Blocking Ebolavirus intercellular spread (Cell Rep) * Letters read on TWiV 1059 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Climate Science Angela – Spider Ballooning (Wikipedia) Kathy – Richard Harris Art Collection Rich – “The Murderbot Diaries” by Martha Wells Alan – Old Gods of Appalachia Vincent – Poetry Foundation
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors.
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Links for this episode * Routine vaccination coverage (CDC) * Outbreak of invasive Group A Streptococcusin children (PIDS) * Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 (Nature) * Outcomes of SARS-CoV-2 omicron variant infections compared with seasonal influenza and RSV infections in adults (CID) * Remdesivir is associated with reduced mortality in COVID-19 patients requiring oxygen (OFID) * Effectiveness of nirmatrelvir/ritonavir against the development of Post–COVID-19 conditions among U.S. veterans (AIM) * Contribute to our MicrobeTV fundraiser at PWB * Letters read on TWiV 1058 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector memory T cells, including highly unconventional MHC-II and MHC-E restricted CD8+ T cells.
Host: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Klaus Früh
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Spike shirts at vaccinated.us (promo code Microbetv) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * HCMV-based attenuated vaccine platform (Sci Rep) * HLA-E-restricted, Gag-specific CD8+ T cells suppress HIV-1 infection (Sci Immunol) * RhCMV/SIV vaccine shows long-term efficacy against SIV challenge (Sci Transl Med) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with nirmatrelvir–ritonavir for COVID-19 in an interdisciplinary community clinic, Nirmatrelvir and molnupiravir and post-COVID-19 condition in older patients, optimal duration of systemic corticosteroids in COVID-19 treatment, association between Guillain-Barré syndrome and COVID-19 infection and vaccination, SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration, Transplanting candidates with COVID-19, and favorable experience of transplant strategy including liver grafts from COVID-19 donors.
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Links for this episode * Health worker–perceived working conditions and symptoms of poor mental health (CDC) * Neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination (The Lancet) * Newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy (JAMA) * Duration of SARS-CoV-2 culturable virus shedding in children (JAMA) * Prescribing outcomes in outpatients treated with PAXLOVID for COVID-19 (PLOS ONE) * Nirmatrelvir and molnupiravir and post–COVID-19 condition in older patients (JAMA) * Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) * Intravenous vitamin C for patients hospitalized with COVID-19 (JAMA) * Association between Guillain-Barré syndrome and COVID-19 infection and vaccination (NH) * SARS-CoV-2 infection correlates with male benign prostatic hyperplasia deterioration (JIM) * Transplanting candidates with COVID-19 (TID) * Favorable experience of transplant strategy including liver grafts from COVID-19 donors (TID) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1056 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the involvement of viruses in the autoimmune disease multiple sclerosis.
Host: Vincent Racaniello
Guests: Jason Botten, Emily Bruce, Jessica Crothers, and Dimitry Krementsov
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Spike shirts at vaccinated.us (promo code Microbetv) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Lab worker contamination with SARS-CoV-2 plasmid DNA (J Clin Micro) * Fractional dose poliovirus vaccine (Vaccine) * No SARS-CoV-2 RNA in Vermont wildlife (Sci Rep) * Predicting SARS-CoV-2 infectivity from RT-PCR (EMBO Mol Med) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged
From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiology of avian H5N1 influenza virus and the threat to humans and other animals.
Host: Vincent Racaniello
Guests: Ron Fouchier, Rafael Medina, and Louise Moncla
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Spike shirts at vaccinated.us (promo code Microbetv) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Centers for Influenza Research and Response Network * Transatlantic spread of avian H5N1 influenza virus (Sci Rep) * In-host diversity of influenza H5N1 virus (PLoS Path) * Influenza H5N1 virus and mass mortality in sea lions (Vet Q.) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19, Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to covid-19 complications, antibiotic use among hospitalized patients with COVID-19 in the United States, one week of oral Camostat vs Placebo in nonhospitalized adults with mild-to-moderate COVID-19, assessment of the available therapeutic approaches for severe COVID-19, optimal duration of systemic Corticosteroids in COVID-19 treatment, effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, local budesonide therapy in the management of persistent hyposmia in suspected non-severe COVID-19 patients, and the safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic Kidney disease and COVID-19.
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Links for this episode * Disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults * Antiviral efficacy of molnupiravir vs ritonavir-nirmatrelvir in patients with symptomatic COVID-19 (The Lancet) * Nirmatrelvir-Ritonavir and COVID-19 mortality and hospitalization among patients with vulnerability to complications (JAMA) * Antibiotic use among hospitalized patients with COVID-19 (OFID) * One week of oral Camostat vs placebo in non-hospitalized adults with COVID-19 * Assessment of the available therapeutic approaches for severe COVID-19 (Nature) * Optimal duration of systemic Corticosteroids in COVID-19 treatment (OFID) * Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and in patients with long-COVID syndrome (Nature) * Local budesonide therapy in the management of persistent hyposmia in suspected COVID-19 patients (JID) * Safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with Kidney disease and COVID-19 * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1052 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19, and accelerated mutation of SARS-CoV-2 in white-tailed deer.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Spike shirts at vaccinated.us (promo code Microbetv) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * 2023 Nobel Prize Physiology or Medicine (Nobelprize.org) * Evading a toll on the road to mRNA vaccines (TWiV 860) * Katalin Karikó‘s overlooked work (Wired) * Accelerated mutation of SARS-CoV-2 in deer (Nat Comm) * Letters read on TWiV 1051 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – The New City. How to Build Our Sustainable Urban Future Angela – 2023 Nobel Peace Prize Alan – The Ruin of All Witches, by Malcolm Gaskill Vincent – France kicks off bird flu vaccination despite trade backlash risk
Listener Pick Charles – David Brooks and the $78 airport meal the internet is talking about John – Periodic Table of the Elements: Origins of the Elements AZ – Bronze statue of laboratory mouse knitting DNA in Russia
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants aged
TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copper transport and homeostasis in cats.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Spike shirts at vaccinated.us (promo code Microbetv) * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Features of Long COVID (Nature) * ERV envelope mediates feline copper homeostasis (Cell Rep) * Letters read on TWiV 1049 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Webb spots a building block of life on Jupiter’s moon Europa Rich – Are we really made of ‘star stuff?’ Learn about your body’s elements Alan – Avian flu has reached the Galàpagos Vincent – Why the US can’t have nice things
Listener Pick Az – Free solo
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses a molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, inhaled fluticasone furoate for outpatient treatment of COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, early antibody treatment, inflammation, and risk of post-COVID conditions, autonomic dysregulation in long-term patients suffering from post-COVID-19 syndrome assessed by heart rate variability, and multiorgan MRI findings after hospitalization with COVID-19 in the UK.
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Links for this episode * Molnupiravir-associated mutational signature in global SARS-CoV-2 genomes (Nature) * Inhaled fluticasone furoate for outpatient treatment of COVID-19 (NEJM) * Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) * Distinguishing features of Long COVID identified through immune profiling (Nature) * Early antibody treatment, inflammation, and risk of post-COVID conditions (mBIO) * Autonomic dysregulation in long-term patients suffering from post COVID-19 syndrome (SR) * Multiorgan MRI findings after hospitalization with COVID-19 in the UK (The Lancet) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1048 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and respiratory droplet transmission of human-isolated avian H3N8 influenza virus between ferrets.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) 4:20 * Postacute sequelae of COVID-19 at 2 years (Nat Med) * Disability-adjusted life years (DALYs) (WHO) * Respiratory droplet transmission of H3N8 virus (Cell) * Letters read on TWiV 1047 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – UN Climate Action and California sues oil companies for exacerbating climate change Brianne – COVID Drugs are a Miracle Cure for Cats Rich – American Prometheus by Kai Bird and Martin J. Sherwin Vincent – Free Carl Zimmer writings
Listener Pick Anne – She wrote to a scientist about her fatigue. It inspired a breakthrough. Alan – This Tiny Parasitic Wasp Can Drill Through Plastic
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City, can high COVID-19 vaccination rates in adults help protect unvaccinated children, Nirmatrelvir/Ritonavir use and hospitalizations or death in previously uninfected non-hospitalized high-risk population with COVID-19, Optimal duration of systemic corticosteroids in COVID-19 treatment, and vaccination after developing long COVID.
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Links for this episode * Wastewater surveillance data as a complement to tracking incidence of influenza A and RSV (CDC) * Chatbot-delivered online intervention to promote seasonal influenza vaccination (JAMA) * Temporal assessment of disparities in California COVID-19 mortality by industry (AOE) * CDC/HICPAC’s plan to weaken guidance for health care respiratory protection and infection control (NNU) * Modelling the impact of a high-uptake bivalent booster scenario on COVID-19 burden (The Lancet) * Can high COVID-19 vaccination rates in adults help protect unvaccinated children? (ES) * Paxlovid use and hospitalizations or death in previously uninfected high-risk population with COVID-19 (JID) * Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) * Vaccination after developing long COVID (IJID) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1046 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Virologist Bob Lamb dies (Northwestern Now) * Lassa virus mRNA vaccine (Nat Commun) * CRISPR engineering of RNA viruses (Sci Adv) * Letters read on TWiV 1045 * Timestamps by Jolene. Thanks!
Weekly Picks Angela – More than 5,000 new species discovered in Pacific deep-sea mining hotspot (journal article) Brianne – The story of our universe may be starting to unravel Rich – Sunlight Changes Unequally All Year Long Alan – Arm swing asymmetry in overground walking Vincent – The Farm at the Javits Center
Listener Pick Asal – Ig Nobel Prizes honor zombie spiders, rock-licking scientists, and a clever commode
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics.
Host: Vincent Racaniello
Guest: Marion Koopmans
Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * SARS-CoV-2 variants in Rotterdam wastewater (Sci Tot Environ) * SARS-CoV-2 in mink and other animals (Transbound Emerg Dis) * Mpox in Netherlands (EuroSurveill) * Divergent SARS-CoV-2 in immunocompromised patient (Emerg Inf Dis) * Accelerated SARS-CoV-2 evolution in deer (Nat Commun) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with COVID-19, and long-term survival after intensive care for COVID-19.
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Links for this episode * China’s health authorities fight surge in cases of unknown origin (BMJ) * Analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses (ASHE) * Prevalence and outcomes of co-infection between SARS-CoV-2 and influenza (IJID) * Comparison of bivalent and monovalent mRNA vaccine boosters (CID) * Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) * Acute blood biomarker profiles predict cognitive deficits after COVID-19 hospitalization (Nature) * Temporal changes in fecal microbiota of patients infected with COVID-19 (BMC) * Long-term survival after intensive care for COVID-19 (AIC) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1042 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradication of poliomyelitis.
Host: Vincent Racaniello
Guests: Raul Andino and Kostya Chumakov
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Engineering OPV (Cell Host Microbe) * Poliopolis (Lancet) * nOPV2 (Polioeradication.org) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-CoV-2 specific humoral and cellular immune responses after contralateral and ipsilateral COVID-19 vaccination, Pfizer and BioNTech receive positive CHMP opinion for Omicron XBB.1.5-adapted COVID-19 vaccine in the European Union, clinical antiviral efficacy of Remdesivir in COVID-19, optimal duration of systemic corticosteroids in COVID-19 treatment, clinical outcomes associated with overestimation of oxygen saturation by pulse oximetry in patients hospitalized with COVID-19, risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination.
Click arrow to play Download TWiV 1040 (19 MB .mp3, 27 min)
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Links for this episode * Public health significance of finding autochthonous melioidosis cases (PLOS) * Human neural larva migrans caused by Ophidascaris robertsi ascarid (EID) * Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics (HHS) * Excess all-cause mortality in China after ending the zero COVID policy (JAMA) * International pediatric COVID-19 severity over the course of the pandemic (JAMA) * Differences in SARS-CoV-2 specific humoral and cellular immune responses after COVID-19 vaccination (eBioMedicine) * Pfizer/BioNTech receive positive CHMP opinion for COVID-19 vaccine in the EU (Pfizer) * Clinical antiviral efficacy of Remdesivir in COVID-19 (JID) * Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) * Clinical outcomes associated with overestimation of oxygen saturation in patients with COVID-19 (JAMA) * Risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination (eClinicalMedicine) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1040 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Jolene Ramsey
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Anti-phage defense via capsid detection (Nature) * Redondoviruses infect commensal amoebae (Cell Host Micro) * A host for redondoviruses (Nat Rev Micro) * Letters read on TWiV 1039 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – “Cosmic Time Machine” Netflix documentary
Kathy – Antarctican accents
Rich – Cymothoa exigua, or the tongue-eating louse, Week of wonder: The case for preserving parasites
Jolene – Perspective article on best practices for improving graduate admissions
Vincent – Why Chandrayaan-3 landed near the moon’s south pole — and why everyone else wants to get there too
Listener Picks Douglas – On Climate Change and (Active) Climate Management
Matt – This Scientist Tracked Bats for Decades and Solved a Mystery About a Deadly Disease
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to clinical and virological treatment failure, incidence of new-onset hypertension post–COVID-19: comparison with influenza, and post-acute sequelae of COVID-19 at 2 years.
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Links for this episode * Modeling poliovirus transmission and responses in New York State (JID) * FDA approves first vaccine for pregnant individuals to prevent RSV in infants (FDA) * Prevention and control of seasonal influenza with vaccines (CDC) * De novo E166V/L50V mutations in an immunocompromised patient treated with nirmatrelvir/ritonavir (CID) * Incidence of new-onset hypertension post–COVID-19 (Hypertension) * Postacute sequelae of COVID-19 at 2 years (Nature Medicine) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1038 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * VITT-like disorder after adenovirus infection (NEJM) * The clot thickens (TWiV 842) * Lessons from VITT (Nat Rev Immunol) * Pan-sarbecovirus neutralizing mAb (Sci Adv) * Letters read on TWiV 1037 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope
Brianne – Question Mark in Space?
Kathy – Quammen interview with Walter Isaacson
Rich – Chrome Music Lab
Vincent – Matters Microbial
Listener Picks Tom – The (second) deadliest virus
Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses Florida local transmission of dengue cases reported in Broward and Miami-Dade counties, infants admitted to US intensive care units for RSV infection during the 2022 seasonal peak, long-term risk of death and readmission after hospital admission with COVID-19 among older adults, safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic kidney disease and COVID-19, Fluvoxamine vs placebo for outpatients with symptomatic COVID-19, the effect of corticosteroids, antibiotics, and anticoagulants on the development of post-COVID-19 syndrome in COVID-19 hospitalized patients 6 months after discharge, long COVID and significant activity limitation among adults, incidence of diabetes following COVID-19 vaccination and SARS-CoV-2 infection in Hong Kong, and diabetes following SARS-CoV-2 infection: Incidence, persistence, and implications of COVID-19 vaccination.
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Links for this episode * Florida local transmission of dengue cases (Outbreak News) * Infants admitted to US ICU for RSV infection (JAMA) * Long term risk of death and readmission after hospital admission with COVID-19 (BMJ) * Outcomes of Nirmatrelvir-Ritonavir Treatment in patients with Kidney disease and COVID-19 (CID) * Fluvoxamine vs placebo for outpatients with symptomatic COVID-19 (OFID) * The effect of corticosteroids, antibiotics, and anticoagulants on the development of post-COVID-19 syndrome in hospitalized patients (CEM) * Long COVID and significant activity limitation among adults (CDC) * Incidence of Diabetes following COVID-19 vaccination and SARS-CoV-2 infection (PLOS) * Diabetes following SARS-CoV-2 infection (BMJ) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1036 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV dissects a study of COVID-19 vaccination which shows that the timing of initial rollout affects disease outcomes more substantially than final coverage or degree of socioeconomic disparity, and discovery of a novel cellular defense comprising a nuclease that is activated by poxvirus infection and cleaves a specific tRNA molecule to inhibit protein synthesis.
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Research assistant position in Rosenfeld Lab CBER/FDA (pdf) * Impact of COVID-19 vaccination trends (Sci Adv) * Poxvirus-activated anticodon nuclease (Sci Adv) * Letters read on TWiV 1035 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Project Hail Mary
Rich – Bird Buddy
Alan – Blood, Sweat, and Pixels and Press Reset
Vincent – Are microplastics spreading infectious disease?
Listener Picks Tom – Henrietta Lacks family settles lawsuit
Kathleen – Why Insect Memories May Not Survive Metamorphosis
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment for COVID-19 impact short and long- term outcomes in a large generalizable population, persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation, core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts.
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Links for this episode * Immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a influenza A vaccine candidate (The Lancet) * Association between nose picking and SARS-CoV-2 incidence (PLOSONE) * Effect of COVID-19 vaccination and booster on maternal-fetal outcomes (Lancet Digital Health) * Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status (The Lancet) * Does monoclonal antibody treatment for COVID-19 impact short and long-term outcomes (BMJ) * Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and inflammation (Angiogenesis) * Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts (STM) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1034 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent speaks with Desirée Townsend about how she felt used and indoctrinated by the anti-vaxx movement, the science surrounding her autoimmune disorder, and why she is no longer the “flu shot cheerleader,” but a cheerleader for flu shots.
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Links for this episode * Desiree on Instagram and LinkedIn * ‘Flu-shot cheerleader’ speaks out (NBC) * ‘Flu-shot cheerleader’ back with a warning (NBC) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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TWiV notes the passing of Harald zur Hausen, dengue breaking records in the Americas, inhibition of SARS-CoV-2 infection and inflammation by modulation of type I IFN, and an armed nanobody that protects mice against influenza A and B disease.
Hosts: Vincent Racaniello, Kathy Spindler, and Angela Mingarelli
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Position in Rosenfeld Laboratory (pdf) * Paul and the Mosquitos (pdf, English) * Other childrens books (SMVIROLOGIA) * Dengue breaking records in Americas (Nature) * Harald zur Hausen, 1936-2023 (Nature) * Vincent interviews zur Hausen (ASM) * COVID-19 and modulation of IFN (Sci Immunol) * Burning down the mouse (TWiV 900) * Armed nanobody protects against influenza (Sci Immunol) * Click chemistry Nobel prizes (The Nobel Prize) * Letters read on TWiV 1033 * Timestamps by Jolene. Thanks!
Weekly Picks Angela – The Deepest Breath
Kathy – Pink snow
Vincent – Scientist vs PowerPoint
Listener Picks Fernando – The Enigma of Reason by Hugo Mercier and Dan Sperber and Language vs. Reality by Nick Enfield
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses predicting COVID-19 incidence using wastewater surveillance data, use of wastewater metrics to track COVID-19 in the US, wastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA counties, association between duration of SARS-CoV-2 positivity and long COVID, rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care, effectiveness of oral Nirmatrelvir/Ritonavir vs. intravenous three-day Remdesivir in preventing progression to severe COVID-19, NIH launching of several phase 2 long-COVID treatment trials.
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Links for this episode * Predicting COVID-19 incidence using wastewater surveillance data (CDC) * Use of wastewater metrics to track COVID-19 in the US (JAMA) * Wastewater-based epidemiology predicts COVID-19-induced new hospital admissions (Nature) * Association between duration of SARS-CoV-2 positivity and long COVID (JID) * Rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care (ACS) * Effectiveness of oral Nirmatrelvir/Ritonavir vs. intravenous three-day Remdesivir in preventing COVID-19 progression (Viruses) * NIH has launched several phase 2 long-COVID treatment trials (NIH) * Fatigue can shatter a person (Atlantic) * Contribute to our Floating Doctors fundraiser at PWB * Letters read on TWiV 1032 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV notes the passing of virologist Michael BA Oldstone, a study to assess the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, and the presence of antibodies to type I interferons in ~40% of patients with West Nile virus encephalitis.
Hosts: Vincent Racaniello, Rich Condit, and Alan Dove
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Links for this episode * MicrobeTV Discord Server * MicrobeTV store at Cafepress * Position in Rosenfeld Laboratory (pdf) * XKCD on antivaxxers * RFK Jr. CDC or FDA head? (Politico) * Performance of rapid antigen tests (Ann Int Med) * Guidance on rapid antigen tests (FDA) * Autoantibodies to IFN in West Nile virus encephalitis (JEM) * Letters read on TWiV 1031 * Timestamps by Jolene. Thanks!
Weekly Picks Rich – The Final Covid-19 Grand Rounds: What Have We Learned?
Alan – Teaching biology to Tibetan Buddhist monks
Vincent – I got it from Agnes by Tom Lehrer and Why Oppenheimer has important lessons for scientists today
Listener Picks Ryan – Paul Offit on PBS Newshour to explain RFK Jr.’s Congressional Hearing
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Central Florida, blood group A enhances SARS-CoV-2 infection, predicting COVID-19 incidence using wastewater surveillance data, a common allele of HLA associated with asymptomatic SARS-CoV-2 infection, prevalence of low-frequency, antiviral resistance variants in SARS-CoV-2 isolates in Ontario, Canada, viral resistance analyses from the Remdesivir phase 3 adaptive COVID-19 treatment trial-1, impact of Molnupiravir treatment on patient-reported COVID-19 symptoms in the phase 3 move-out trial, Molnupiravir for treatment of adults with mild or moderate COVID-19, delayed intubation associated with in-hospital mortality in patients with COVID-19 respiratory failure who fail heated and humified high flow nasal canula, relationship between azithromycin and cardiovascular outcomes in unvaccinated patients with COVID‐19 and preexisting cardiovascular disease, and the effects of COVID-19 on cognitive performance in a community-based cohort, clinical phenotypes and quality of life to define post-COVID-19 syndrome.
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Links for this episode * Use of RSV vaccines in older adults (CDC) * Case report of leprosy in Central Florida (EID) * Blood group A enhances SARS-CoV-2 infection (Blood) * Predicting COVID-19 incidence using wastewater surveillance data (EID) * Common allele of HLA associated with asymptomatic SARS-CoV-2 infection (Nature) * Prevalence of low-frequency antiviral resistance variants in SARS-CoV-2 isolates (JAMA) * Viral resistance analyses from the Remdesivir phase 3 treatment trial (JID) * Impact of Molnupiravir treatment on patient-reported COVID-19 symptoms (CID) * Molnupiravir for treatment of adults with mild or moderate COVID-19 (CMI) * Delayed intubation associated with in-hospital mortality in patients with COVID-19 (BMC) * Relationship between Azithromycin and cardiovascular outcomes in unvaccinated patients with COVID‐19 (JAHA) * The effects of COVID-19 on cognitive performance in a community-based cohort (eClinical) * Clinical phenotypes and quality of life to define post-COVID-19 syndrome (eClinical) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1030 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
David Tuller returns to TWiV to provide an update on ME/CFS, the PACE trial, developments related to the NICE guidelines, and how similar practices and ideologies are being applied to long COVID.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episode * MicrobeTV Discord Server * David Tuller at virology blog * CFS, a long tangled tale (virology blog) * Request for Correction of Prevalence Rates Cited in FND Paper (virology blog) * Estimates of long COVID prevalence (virology blog) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * MicrobeTV Discord Server * First gene therapy for hemophilia A approved (FDA) * Luxurna, gene therapy for vision loss (FDA) * Anti-RSV monoclonal antibody approved (FDA) * Trial of single-dose Nirsevimab (NEJM) * Letters read on TWiV 1028 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Phoenix hits 110 degrees for the 19th day in a row, setting national record
Brianne –James Webb Telescope One Year Anniversary Photo
Kathy – Drone awards photos
Alan – WHO Film Festival winners
Vincent – Thinking, Fast and Slow by Daniel Kahneman
Listener Picks David – The Mass Extinction Debates: A Science Communication Odyssey
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States, Omicron subvariant BA.5 efficiently infects lung cells, COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019, T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with Delta or Omicron variants, a common allele of HLA is associated with asymptomatic SARS-CoV-2 infection, and the immunology of long COVID.
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Links for this episode * Transmission of SARS-CoV-2 in white-tailed deer in the United States (Nature) * Omicron subvariant BA.5 efficiently infects lung cells (Nature) * COVID-19 scent dog research highlights during the pandemic of December 2019 (JOM) * T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes (JID) * Common allele of HLA is associated with asymptomatic SARS-CoV-2 infection (Naure) * Immunology of long COVID (Nature) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1027 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Dan Wilson
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Links for this episode * MicrobeTV Discord Server * Joe Rogan’s worst misinformation yet, with RFK Jr. (YouTube) * Every first vaccine has been tested in placebo-controlled trials before going to market. + Polio + Measles + HPV + COVID-19 + HepB + Haemophilus influenzae B + Pertussis + Diphtheria + Tetanus + Pneumococcal + Mumps + Meningococcal + Chickenpox + HepA * KiGGS Study results on atopic diseases after vaccination (Vaccine) * Vaccine history by year (CHOP) * Financing vaccines in the 21st Century (Nat Acad Press) * DALY rates from non-communicable diseases (Our World in Data) * Science loses one to creationism (WaPo) * Children’s Health Defense (Wikipedia) * COVID-19 vaccines saved 3 million US lives (CIDRAP) * Beyond the Noise with Paul Offit (YouTube) * Letters read on TWiV 1026 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz G.O.A.T.S – Louis Armstrong, Duke Ellington, Ella Fitzgerald
Brianne –Defining the Anthropocene?
Kathy – How to use your thermostat on A/C
Rich – Star Trek: Strange New Worlds
Vincent – Step Aside, Joe Biden
Listener Picks Kim – Virus found in a boreal lake links ssDNA and dsDNA viruses and Structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection, COVID-19 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with Nirmatrelvir plus Ritonavir versus untreated controls, exaggerated blood pressure elevation in response to orthostatic challenge a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization, long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism, and risk of cardiovascular disease after COVID‐19 diagnosis among adults with and without diabetes.
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Links for this episode * New risk assessment for H5N1 avian flu viruses (CDC) * Development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure (Virology) * Repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection (eClinicalMedicine) * COVID-19 Rebound Study (CID) * Exaggerated blood pressure elevation in response to orthostatic challenge (AN) * Long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism (TR) * Risk of Cardiovascular disease after COVID‐19 diagnosis among adults with and without Diabetes (JAHA) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1025 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test for measuring production consistency of oral poliovirus vaccine.
Host: Vincent Racaniello Guest: Kostya Chumakov
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Links for this episode * MicrobeTV Discord Server * Mikhail Chumakov (Wikipedia) * MAPREC (WHO pdf) * Kostya Chumakov Symposium (YouTube) * Maprec and monkey neurovirulence of OPV (PNAS) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and how the COVID-19 pandemic has impacted her craft.
Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Katherine Wu
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Links for this episode * MicrobeTV Discord Server * All Katherine’s articles at The Atlantic * Vaccines still blocking severe disease (The Atlantic) * Calling Omicron mild is wishful thinking (The Atlantic) * Tattoos do odd things to the immune system (The Atlantic) * The Story Collider * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 Infection, effectiveness of the COVID-19 bivalent vaccine, oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults ages 18-50 years, genome-wide association study of long COVID, vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections, and high incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID.
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Links for this episode * Autochthonous leprosy in the United States (NEJM) * Systematic review to identify novel clinical characteristics of Monkeypox (Archives of Virology) * Two-year duration of immunity of inactivated poliovirus vaccine (JID) * Evaluation of novel oral polio vaccine type 2 SIA impact in a outbreak of vaccine-derived poliovirus in Nigeria (IDSA) * Performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 (AIM) * Effectiveness of the COVID-19 bivalent vaccine (OFID) * Oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults (CID) * Genome-wide association study of long COVID (medRxiv) * Vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections (JID) * High incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID (AJM) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1022 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evolution of SARS-CoV-2 from January 2020 through Omicron.
Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Trevor Bedford
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Links for this episode * MicrobeTV Discord Server * Nextstrain * Household influenza testing (Influenza Other Resp Viruses) * SARS-CoV-2 outbreak Washington (Sci Transl Med) * SARS-CoV-2 surveillance, Washington (Emerg Inf Dis) * S1 changes drive SARS-CoV-2 clade success (Cell Host Micro) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant in Hong Kong, safety, immunogenicity and protection of heterologous boost with an aerosolized Ad5-nCoV after two-dose inactivated COVID-19 vaccines in adults, awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure, melatonin effects on sleep quality of COVID-19 patients, female reproductive health impacts of Long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders, and incident autoimmune diseases in association with SARS-CoV-2 infection.
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Links for this episode * Guidance on measles during the summer travel season (CDC) * Infectious Diseases Society of America guidelines on the diagnosis of COVID-19 (CID) * SARS-CoV-2 variants and infection rates among household and nonhousehold contacts (CDC) * Effect of COVID-19 vaccination on household transmission of SARS-CoV-2 in the Omicron era (IJID) * Incidence of myopericarditis after mRNA COVID-19 vaccination (Science Direct) * Intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and Omicron BA.2 variant (JID) * Safety, immunogenicity and protection of heterologous boost with Ad5-nCoV after two-dose inactivated COVID-19 vaccines (The Lancet) * Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure (BMC) * Melatonin effects on sleep quality of COVID-19 patients (BMJ) * Female reproductive health impacts of Long COVID and associated illnesses (FRS) * Incident autoimmune diseases in association with SARS-CoV-2 infection (CR) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1020 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere.
Host: Vincent Racaniello
Guest: Eddie Holmes
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Links for this episode * MicrobeTV Discord Server * Huanan Seafood Market early COVID-19 epicenter (Science) * SARSr-CoV-2 in Malayan Pangolins (PLoS Path) * Zoonotic risk of farmed animals (Cell) * Virusea at bat-tick interface (Microb Genom) * Influenza H3N8 virus in southern China (J Virol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the CDC vaccine advisory group recommending the newly approved RSV vaccines, association of culturable-virus detection and household transmission of SARS-CoV-2, prevention of COVID-19 following a single intramuscular administration of Adintrevimab, real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19, and COVID-19 convalescent plasma outpatient therapy to prevent outpatient hospitalization.
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Links for this episode * CDC vaccine advisory group recommends RSV vaccines * Association of culturable-virus detection and household transmission of SARS-CoV-2 (JID) * Prevention of COVID-19 following intramuscular administration of Adintrevimab (OFID) * Real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19 (CID) * COVID-19 convalescent plasma outpatient therapy to prevent hospitalization (CID) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1018 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, and public and political perception of scientific risk.
Host: Vincent Racaniello
Guests: Susan Weiss, Rick Bushman, Gigi Gronvall, and David Joanson
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Links for this episode * MicrobeTV Discord Server * Huanan Seafood Market early COVID-19 epicenter (Science) * Spillover market with Michael Worobey (TWiV 876) * Unclassified intelligence on SARS-CoV-2 origins (IC) * Conspiracy theories about COVID-19 (Foreign Policy) * COVID-19 not from lab leak (Globe and Mail) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with extended duration Nirmatrelvir/Ritonavir, anemia as a risk factor for disease progression in patients admitted for COVID-19, impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome, post-COVID condition in patients with inflammatory rheumatic diseases, outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months, metformin reduces SARS-CoV-2 in a Phase 3 randomized placebo controlled clinical trial, persistent serum protein signatures define an inflammatory subcategory of long COVID, and the relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome.
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Links for this episode * Surveillance to track progress toward poliomyelitis eradication (CDC) * Genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3 (Nature) * Evaluation of Oseltamivir to prevent hospitalization in outpatients with Influenza (JAMA) * Viral emissions into air and environment after SARS-CoV-2 human challenge (The Lancet) * Has COVID-19 threatened routine childhood vaccination (Health Affairs) * Successful treatment of COVID-19 with extended duration Nirmatrelvir/Ritonavir (OFID) * Anemia as a risk factor for disease progression in patients admitted for COVID-19 (Nature) * Impact of fatigue as the determinant of functional limitations among patients with post-COVID-19 syndrome (BMJ) * Post-COVID condition in patients with inflammatory rheumatic diseases (The Lancet) * Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition (The Lancet) * Metformin reduces SARS-CoV-2 in a Phase 3 placebo controlled clinical trial (MedRxiv) * Persistent serum protein define an inflammatory subcategory of long COVID (Nature) * Relevance of pacing strategies in managing symptoms of post-COVID-19 syndrome (JTM) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1016 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent and Rich travel to Ft. Detrick to visit USAMRIID and speak with Todd, Crystal, John and Jay about their careers, their research, and the mission of the US Army Medical Institute of Infectious Diseases.
Host: Vincent Racaniello and Rich Condit
Guests: Todd Bell, Crystal Burke, John Dye, and Jay Hooper
Opinions, interpretations, conclusions, and recommendations are those of the panelists and no official endorsement by the U.S. Army should be inferred.
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Links for this episode * MicrobeTV Discord Server * USAMRIID * Mpox virus in testes of nonhuman primates (Nat Micro) * Efficacy of equine encephalitis virus-like particle vaccine (Viruses) * Prophylaxis with SARS-CoV-2 mAb (Antimicrob Agents Chemother) * Needle-free jet injection of DNA vaccine (PLoS One) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses estimates of SARS-CoV-2 seroprevalence and incidence of primary SARS-CoV-2 infections among blood donors, by COVID-19 vaccination status, smart thermometer–based participatory surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic, COVID-19 vaccine mandates, changing severity and epidemiology of adults hospitalized with COVID-19 in the United States after introduction of COVID-19 vaccines, effectiveness of COVID-19 treatment with Nirmatrelvir–Ritonavir or Molnupiravir among U.S. veterans, national trends in anticoagulation therapy for COVID-19 hospitalized adults in the United States, development of a definition of postacute sequelae of SARS-CoV-2 infection, neuroinflammation after COVID-19 with persistent depressive and cognitive symptoms, long COVID clinical phenotypes up to six months after infection identified by latent class analysis of self-reported symptoms, and coronary microvascular health in symptomatic patients with prior COVID-19 infection.
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Links for this episode * Estimates of SARS-CoV-2 seroprevalence and incidence of infections among blood donors, by vaccination status (CDC) * Smart thermometer–based surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic (JAMA) * COVID-19 vaccine mandates (GOV) * Changing epidemiology of adults hospitalized with COVID-19 after introduction of vaccines (CID) * Effectiveness of COVID-19 treatment with Nirmatrelvir–Ritonavir or Molnupiravir among U.S. Veterans (ACP Journals) * National trends in Anticoagulation therapy for COVID-19 (IDSA) * Development of a definition of postacute sequelae of SARS-CoV-2 infection (JAMA) * Neuroinflammation after COVID-19 with depressive and cognitive symptoms (JAMA) * Long COVID clinical phenotypes up to six months after infection identified by latent class analysis of self-reported symptoms (OFID) * Coronary microvascular health in patients with prior COVID-19 infection (EACVI) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1014 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbreaks in farmed poultry, and isolation of a monoclonal antibody against the influenza virus neuraminidase that inhibits infection with a wide range of A and B isolates.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episode * Register for ASV 2023 * Research assistant position at FDA (pdf) * MicrobeTV Discord Server * Avian influenza H5N1 (Eurosurveillance) * Pan-influenza NA antibody (Nature) * World Animal Health Information System * Timestamps by Jolene. Thanks!
Weekly Picks Angela – May’s best science images – Nature Kathy – Historical reasons for resistance to recognizing airborne transmission Rich – Scan of Titanic reveals wreck as never seen before – BBC News Alan – Science Education in an Age of Misinformation Vincent – Equity, Diversity and Inclusion: When communication all changed
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants and frequency of acute symptoms, prospective study of key correlates for household transmission of SARS-CoV-2, Pfizer’s PAXLOVID™ receiving FDA approval for adult patients at high risk of progression to severe COVID-19, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, development of a definition of postacute sequelae of SARS-CoV-2 infection, COVID-19 and risk for mental disorders among adults in Denmark, risk of new post-COVID mental disorders higher only in older patients.
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Links for this episode * Potential for recurrent Mpox outbreaks among men who have sex with men (CDC) * Association between SARS-CoV-2 variants and frequency of acute symptoms (OFID) * Key correlates for household transmission of SARS-CoV-2 (OFID) * PAXLOVID receiving FDA approval for patients at high risk of severe COVID-19 (Pfizer) * Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients with COVID-19 (The Lancet) * Development of a definition of postacute sequelae of SARS-CoV-2 (JAMA) * COVID-19 and risk for mental disorders among adults in Denmark (JAMA) * Risk of new post-COVID mental disorders higher only in older patients (CIDRAP) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1012 * Dr. Griffin’s COVID treatment summary (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution of aquatic viruses and their microbial communities.
Host: Vincent Racaniello
Guests: Fred Aylward and Jud Fuhrman
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Links for this episode * MicrobeTV Discord Server * 11th Aquatic Virus Workshop * Endogenization of giant virus genomes in green algae (Nature) * Red Queen dynamics in marine viruses (Nature) * Biogeography of marine giant viruses (ISME Commun) * Marine prokaryotic community structure (Nat Commun) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected humans, safety of the BNT162b2 COVID-19 vaccine in children aged 5 to 17 years, and statement on the antigen composition of COVID-19 vaccines.
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Links for this episode * HIV surveillance report (CDC) * FDA voted in favor of approving Abrysvo vaccine (Pfizer) * Canine olfactory detection of SARS-CoV-2-infected humans (Annals of Epidemiology) * Safety of the BNT162b2 COVID-19 vaccine in children (JAMA) * Statement on the antigen composition of COVID-19 vaccines (WHO) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1010 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne.
Host: Vincent Racaniello
Guests: Kanta Subbarao and Maria von Kerkhove
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Links for this episode * MicrobeTV Discord Server * Nidovirus Symposium, Montreux * WHO Collaborating Centre for Influenza, Melbourne * Maria von Kerkhove (Wikipedia) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortality among selective serotonin reuptake inhibitor users, risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses, trajectories of the evolution of post COVID-19 condition, and efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19.
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Links for this episode * Virus variant clinical performance of a SARS-CoV-2 rapid antigen test (CID) * Ventilation in buildings (CDC) * COVID-19 mortality among SSRI users (CMI) * Risk of post-acute sequelae of SARS-CoV-2 infection associated with sleep apnea (SLEEP) * Trajectories of the evolution of post COVID-19 condition (IJID) * Efficacy of cognitive behavioral therapy targeting fatigue following COVID-19 (CAD) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1008 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli
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Links for this episode * Register for ASV 2023 * Research assistant position at FDA (pdf) * MicrobeTV Discord Server * nOPV2 after two years (Polioeradication) * Raccoon distemper in Toronto (CityNews Everywhere) * NIH reinstates EcoHealth grant (Nature) * Chromosomal breakage by EBNA1 (Nature) * Agent of chromosomal instability (Nature) * Timestamps by Jolene. Thanks!
Weekly Picks Angela – Night Science Kathy – Kermit, Jim Henson, Rainbow Connection Rich – Alexander Skarsgård Explains the Answer to Everything Vincent – Beyond the Noise with Dr. Paul Offit
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age, influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults, COVID-19 surveillance after expiration of the public health emergency declaration, provisional mortality data, targeted vaccine messaging to promote COVID-19 vaccines for children and youth, vaccines and related biological products advisory committee meeting June 15, 2023 announcement, how to overhaul the CDC, impact of SARS-CoV-2 variants on inpatient clinical outcome, prevalence of post-coronavirus disease condition 12 weeks after Omicron infection compared with negative controls and association with vaccination status, gut bacteria cocktail helps long COVID, and gut microbiota‐derived symbiotic formula (SIM01) as a novel adjuvant therapy for COVID‐19.
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Links for this episode * Immunogenicity and tolerability of a bivalent norovirus vaccine in children (HVI) * Influenza hemagglutinin stem nanoparticle vaccine induces neutralizing antibodies in healthy adults (STM) * COVID-19 surveillance after expiration of the public health emergency declaration (CDC) * Provisional mortality data (CDC) * Targeted messaging to promote COVID-19 vaccines for children and youth (Pediatrics) * Vaccines and biological products advisory committee meeting announcement (FDA) * How to overhaul the C.D.C (NYTIMES) * Impact of SARS-CoV-2 variants on inpatient clinical outcome (CID) * Prevalence of post-COVID19 condition 12 weeks after Omicron infection and vaccination status (CID) * Gut bacteria cocktail helps long COVID (MedPage) * Gut microbiota‐derived synbiotic formula as a therapy for COVID‐19 (NIH) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1006 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Register for ASV 2023 * Research assistant position at FDA (pdf) * MicrobeTV Discord Server * Mirusviruses link herpesvirus to giant viruses (Nature) * Tara Oceans expeditions * T cell vaccine protects against severe COVID (Cell) * Letters read on TWiV 1005 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Immune #67: Can T cells Live Forever? Kathy – Hazel Scott, Trinidad Jazz star Alan – The Last Navigator, Steve Thomas Vincent – Nasal Spray Covid Vaccines: Hope or Hype?
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United State, association between SARS-CoV-2 and metagenomic content of samples from the Huanan Seafood Market, researchers disagree over how bad it is to be reinfected and whether COVID-19 can cause lasting changes to the immune system, virtual care and emergency department use during the COVID-19 pandemic among patients of family physicians in Canada, vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers than placebo, NVX-CoV2373 vaccine efficacy against hospitalization, comparative effectiveness of the SARS-COV-2 vaccines during Delta dominance, assessment of gender-specific COVID-19 case fatality risk per malignant neoplasm type, clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir among patients living in nursing homes, timing of intubation and ICU mortality in COVID-19 patients, real-life experience with Remdesivir for treatment of COVID-19 among older adults, and how long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA from the upper respiratory tract during acute infection.
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Links for this episode * FDA approves Arexvy, the first RSV vaccine approved in the US (FDA) * Association between SARS-CoV-2 and content of samples from the Huanan Seafood Market (bioRxiv) * Researchers disagree over how bad it is to be reinfected with COVID-19 and lasting changes to the immune system (Nature) * Virtual care and emergency department use during the COVID-19 Pandemic among patients of family physicians (JAMA) * Vaccination with BCG-Denmark did not result in a lower risk of COVID-19 among health care workers (NEJM) * NVX-CoV2373 vaccine efficacy against hospitalization (Vaccine) * Comparative effectiveness of the SARS-COV-2 vaccines during Delta (Cell) * Assessment of gender-specific COVID-19 case fatality risk (JAMA) * Clinical outcomes following treatment for COVID-19 with Nirmatrelvir/Ritonavir and Molnupiravir (JAMA) * Timing of intubation and ICU mortality in COVID-19 patients (BMC) * Real-life experience with Remdesivir for treatment of COVID-19 (JAC) * Long COVID brain fog and muscle pain are associated with longer time to clearance of SARS-CoV-2 RNA (Frontiers) * Contribute to our FIMRC fundraiser at PWB * Letters read on TWiV 1004 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent and Kathy travel to Atlanta for APHL ID Lab Con, a conference focused on the latest developments in detection and characterization of infectious diseases of public health concern, and speak with Megan, Ryan, and Kirsten about the workings of public health and clinical laboratories.
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Megan Crumpler, Ryan Relich, and Kirsten St. George
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Links for this episode * MicrobeTV Discord Server * APHL Lab ID CON * Association of Public Health Laboratories * Orange County Public Health Laboratory * Division of Clinical Microbiology, Indiana University Health * Virology Laboratory, NYSDOH * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associated with long COVID syndrome in COVID-19 survivors, and clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”.
Click arrow to play Download TWiV 1002 (27 MB .mp3, 44 min)
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Links for this episode * Completeness and spin of medRxiv preprint and published abstracts of COVID-19 randomized clinical trials (JAMA) * Lessons learned from a COVID-19 dog screening pilot (JAMA) * SARS-CoV-2 reinfection and severity of the disease (Viruses) * Effectiveness of COVID-19 bivalent vaccine (medRxiv) * Molnupiravir and risk of post-acute sequelae of COVID-19 (BMJ) * Risk of new-onset long Covid following reinfection with SARS-CoV-2 (medRxiv) * Low vitamin D levels are associated with Long COVID in COVID-19 survivors (JCEM) * Clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for treatment of Long-COVID19 (NIH) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1002 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k–12 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post–COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19.
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Links for this episode * Update on vaccine-derived poliovirus outbreaks (CDC) * The dream of wiping out polio might need a rethink (NPR) * Risk of death in patients hospitalized for COVID-19 vs influenza (JAME) * French mpox cluster includes fully vaccinated patients (CIDRAP) * Two individuals with potential Monkeypox reinfection (The Lancet) * Epidemiologic and clinical features of Mpox-associated deaths (CDC) * FDA authorizes changes to simplify use of Bivalent mRNA COVID-19 vaccines (FDA) * Omicron variant predominance among infants born to people with SARS-CoV-2 (Pediatrics) * Severe maternal morbidity and mortality of pregnant patients with COVID-19 (JAMA) * Sickness presenteeism in healthcare workers during the COVID-19 pandemic (ICHE) * Ventilation improvements among K–12 public school districts (CDC) * Risk factors and vectors for SARS-CoV-2 household transmission (The Lancet) * SARS-CoV-2 neutralising antibodies after bivalent vs monovalent (The Lancet) * Durability of bivalent boosters against Omicron subvariants (NEJM) * Nirmatrelvir and risk of hospital admission or death in adults with COVID-19 (BMJ) * Real world effectiveness of Monoclonal Antibodies for treatment of COVID-19 (AIM) * Study on ACE inhibitor and ARB effect on COVID-19 patient outcomes (JAMA) * Efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19 (JAMA) * High-dose corticosteroids in non-ventilated COVID-19 patients with hypoxia (The Lancet) * Risk of autoimmune diseases in patients with COVID-19 (eClinical) * Definition of post–COVID-19 condition (JAMA) * Sleep disturbance severity and correlates in Post-acute Sequelae of COVID-19 (JGIM) * Contribute to our ASTMH fundraiser at PWB * Letters read on TWiV 1001 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, and Angela Mingarelli
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Links for this episode * TWiV #1: West Nile virus * TWiV #100: TWiV catches a big fish * TWiV #200: Threading the NEIDL * TWiV #300: So happy together * TWiV #400: Harold ‘400’ Varmus, a scientist for all seasons * TWiV #500: Keep virology weird * Randal Despommier * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an experimental infectious attenuated COVID-19 vaccine that elicits superior mucosal and systemic immunity in hamsters.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Register for ASV 2023 * MicrobeTV Discord Server * Jha ignores TWiV contribution to disseminating science information (STAT) * Surveillance of SARS-CoV-2 at the Huanan Market (Science) * Pandas in the Huanan Market? (ArsTechnica) * Infectious attenuated COVID-19 vaccine candidate (Nature Micro) * Virus attenuation by codon pair deoptimization (Cell Rep) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Conductor/composer: Gill Evans. Produced Sketches of Spain, Porgy And Bess. Quincey Jones. Numerous albums, all kinds of music. Duke Ellington. Prolific musician, pianist, and composer. Antonio Carlos Jobim. Signature album: Sound track from the film – Black Orpheus. Signature songs: Girl From Ipanema; The Waters of March. Brianne – This is what it sounds like when plants cry Kathy – I know who you are by Barbara Rae-Venter Alan – Svalbard seed vault virtual tour Vincent – We’re Asking the Impossible of Vaccines by Katherine Wu
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics associated with post–COVID-19 condition among non-hospitalized adolescents and young adults, within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals, live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters, Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, COVID-19 convalescent plasma utilization in the United States, FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19, anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO), anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19, triple combination therapy with two antivirals and monoclonal antibodies for persistent or relapsed SARS-CoV-2 infection in immunocompromised patients, and the breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of long COVID symptoms.
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Links for this episode * White House COVID adviser calls on doctors to combat medical information (STAT) * Adeno-associated virus type 2 in US children with acute severe hepatitis (Nature) * Genomic investigations of unexplained acute hepatitis in children (Nature) * Surveillance of SARS-CoV-2 at the Huanan Seafood Market (ChinaXiv) * Vaccine effectiveness against hospitalization among pediatric SARS-CoV-2 cases (PLOS) * Effectiveness of BNT162b2 after extending the series dosing interval in children (Nature) * Prevalence and characteristics associated with post–COVID-19 condition (JAMA) * Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals (Nature) * Replication-competent-attenuated vaccine sCPD9 elicits immunity to SARS-CoV-2 variants (Nature) * Fc-γR antibody functions needed for SARS-CoV-2 variant protection via vaccination (Nature) * COVID-19 convalescent plasma utilization in the United States (CID) * FDA authorizes Gohibic injection for the treatment of COVID-19 (FDA) * IFX-1 antibody vs. supportive care for severe COVID-19 patients (Lancet) * Vilobelimab therapy for COVID-19 critically ill patients on mechanical ventilation (Lancet) * Triple combo therapy for relapsed SARS-CoV-2 in immunocompromised patients with antivirals and antibodies (CID) * Neutralizing antibody response breadth to SARS-CoV-2 tied to Long COVID presence (medRxiv) * Neurological Long COVID pathogenesis and potential therapies (Journal Cells) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 998 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Mohsan Saeed
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Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server • Spike and nsp6 determinants of Omicron attenuation (Nature) •China releases genomic data from Wuhan market (Science) •Timestamps by Jolene. Thanks!
Weekly Picks Rich – For pianist Dan Tepfer, improvisation is the mother of Bach’s Inventions Alan – HMS Victory 3D animated tour Vincent – The Fight Over Penn Station and Madison Square Garden
Listener Picks Douglas – How’s Your City Doing? Ask the Honeybees.
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-flow nasal cannula and outcomes in COVID-19, severe infection and risk of Cardiovascular disease, and the risk factors associated with post−COVID-19 condition.
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Links for this episode * Antibiotics don’t reduce risk of death from viral respiratory infections (CIDRAP) * ABO blood types and SARS-CoV-2 infection (Nature) * Maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization (Nature Medicine) * Association of treatment with Nirmatrelvir and risk of post–COVID-19 (JAMA) * Ventilated patients with COVID-19 had a higher chance of in-hospital death with usage of nasal cannula oxygen (IARS) * High-flow nasal cannula and outcomes in COVID-19 (IARS) * Severe infection and risk of cardiovascular disease (AHA) * Risk factors associated with post−COVID-19 condition (JAMA) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 996 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.
Click arrow to play Download TWiV 995 (74 MB .mp3, 123 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
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Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server • More evidence for SARS-CoV-2 spillover (Zenodo) •Polio cases linked to nOPV2 (Science; GPEI statement) •nOPV2 on TWiV 756 •Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe) •Stability of nOPV2 in children (npj Vaccines) •2A changes compensate for 5′-UTR disruptions (Virology) •HBV shifts from naked to enveloped (Nat Comm) •Letters read on TWiV 995 •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons Brianne – Science Museums Take Stock of 1.1 Billion Objects from Around the World Vincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York
Listener Picks Gary – Tony Fauci on PBS Stefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.
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Links for this episode
- cVDPV2 detections in Burundi and the DRC (PGEI)
- Novel oral polio vaccine type 2 story (The Lancet)
- Prior COVID-19 infection associated with risk of diagnosed erectile dysfunction (IJIR)
- Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection (BMJ)
- Protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals(The Lancet)
- Effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths (The Lancet)
- Projected COVID-19 mortality reduction from Paxlovid rollout (JAMA)
- SARS-CoV-2 mRNA vaccines decouple anti-viral immunity (Nature)
- Contribute to our ASTMH fundraiser at PWB
- Dr. Griffin’s treatment guide (pdf)
- Letters read on TWiV 994
- Don’t crush Paxlovid (pdf)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies.
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Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Janet Sinsheimer on TWiV 653 •Clearance of chronic poliovirus infection by remdesivir (Front Immunol) •Autoimmunity induced by SARS-CoV-2 infection (Nat Comm) •Letters read on TWiV 993 •Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Xkcd: Lymphocytes Kathy – A brief history of Parafilm with video Alan – Mapping and exploring the USS Monitor wreck Vincent – Skype a Scientist
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update, Dr. Griffin discusses clearance of longstanding, immune-deficiency-associated, vaccine-derived poliovirus infection following remdesivir therapy for chronic SARS-CoV-2 infection, SARS-CoV-2 exposure in New York City rats, clinical characteristics and outcomes of children with SARS-CoV-2 infection during the Delta and Omicron variant-dominant periods in Korea, exhaled breath aerosol shedding of SARS-CoV-2 variants, outpatient treatment of COVID-19 and the development of long COVID over 10 months, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, assessment of the risk of venous thromboembolism in nonhospitalized patients with COVID-19, and the optimal duration of systemic corticosteroids in COVID-19 treatment.
Click arrow to play Download TWiV 992 (19 MB .mp3, 32 min)
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Links for this episode * Clearance of vaccine-derived poliovirus following remdesivir therapy for SARS-CoV-2 infection (Frontiers) * SARS-CoV-2 exposure in Norway rats from New York City (mBio) * Clinical characteristics and outcomes of children with SARS-CoV-2 Infection in Korea (JKMS) * Exhaled breath aerosol shedding of SARS-CoV-2 variants (CID) * Outpatient treatment of COVID-19 and the development of Long COVID (The Lancet) * Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) * Risk of venous thromboembolism in nonhospitalized patients with COVID-19 (JAMA) * Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 992 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
On this episode of TWiV, the observation that the 1918 influenza virus is not lethal in nonhuman primates and implications for studies on viral virulence, and mRNA vaccines that control and resolve human papillomavirus-associated cancers in mice.
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Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •1918 influenza virus not lethal in nonhuman primates (J Virol) •mRNA vaccines control HPV-associated tumors (Sci Trans Med) •Letters read on TWiV 991 •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Piano: Art Tatum/Thelonius S. Monk/Dave Brubeck/Bill Evans/George Shearing/Herbie Hancock/Chick Corea/Keith Jarret/Diana Krall/Eliane Elias/Horace Silver. Honorable mention: Oscar Peterson/Erroll Garner/Ramsey Lewis/Dr. John/Duke Ellington Rich – Protein synthesis: an epic on the cellular level Alan – Thomas Was Alone Vincent – I called for more research on the COVID ‘lab leak theory.’ Here’s what I found out
Listener Pick Carol – The Exceptions: Nancy Hopkins, MIT, and the fight for Women in Science
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses confronting the evolution and expansion of anti-vaccine activism in the USA in the COVID-19 era, the effectiveness of maternal Influenza vaccination in Peru, characteristics and predictors of persistent symptoms post-COVID-19 in children and young people, parental nonadherence to health policy recommendations for prevention of COVID-19 transmission among children, community-onset bacterial coinfection in children critically ill with SARS-CoV-2 infection, bivalent booster effectiveness against severe COVID-19 outcomes in Finland, viral kinetics of sequential SARS-CoV-2 infections, risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in intensive care patients, immunomodulators for severe COVID19 in transplant patients: do they increase the risk of secondary infection, long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population, cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection, one-year adverse outcomes among us adults with Post–COVID-19 condition vs those without COVID-19 in a large commercial insurance database, and long-term gastrointestinal outcomes of COVID-19.
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Links for this episode * Confronting the evolution and expansion of anti-vaccine activism (The Lancet) * Effectiveness of maternal influenza vaccination in Peru (OFID) * Characteristics and predictors of persistent symptoms post-COVID-19 (BMJ) * Parental nonadherence to health policy recommendations for prevention of COVID-19 (JAMA) * Community-onset bacterial coinfection in children ill with SARS-CoV-2 infection (OFID) * Bivalent booster effectiveness against severe COVID-19 outcomes (medRxiv) * Viral kinetics of sequential SARS-CoV-2 infections (medRxiv) * Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID) * Immunomodulators for severe COVID-19 in transplant patients (TID) * Long-term cardiovascular outcomes in COVID-19 survivors among non-vaccinated population (eClinicalMedicine) * Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection (BMJ) * One year adverse outcomes among US adults with post COVID-19 condition vs those without COVID-19 (JAMA) * Long-term gastrointestinal outcomes of COVID-19 (Nature) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 990 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV to explains a study on presence of COVID-19 vaccine mRNA in the blood, and the isolation of cross-protective monoclonal antibodies against common endemic respiratory viruses.
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Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Paul Berg obituary •Spike mRNA in blood (J Path Micro Imm) •Spike mRNA in blood (Biomedicine) •Cross-protective mAbs against respiratory viruses (Nat Comm) •RSV prefusion F protein vaccine in older adults (NEJM) •Ad26.RSV.preF–RSV preF protein vaccine (NEJM) •Letters read on TWiV 989 •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Drums: Sunny Payne (Count Basie Orchestra); Buddy Rich (Count Basie Orchestra); Rufus Jones (Maynard Ferguson Orchestra); Joe Morello (Dave Brubeck Quartet). Brianne – A Scientific Investigation of ‘The Last of Us’ Fungal Pandemic Kathy – “That’s What They Say” podcast about pronunciation of “primer.” Rich – Slow motion art: 1 and 2 Vincent – Grammarly
Listener Pick Charles – Psychologist Daniel Levitin dissects Pink Floyd’s ‘Dark Side of the Moon’
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses FDA authorizing the first over-the-counter at-home test to detect both influenza and COVID-19, monoclonal antibody for the prevention of respiratory syncytial virus infection in infants and children, epidemiologic characteristics of SARS-CoV-2 recombinant variant XBB.1.5, COVID-19 vaccines vs pediatric hospitalization, maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life, immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children, fatal fulminant cerebral edema in six children with SARS-CoV-2 Omicron BA.2 infection in Taiwan, certifying deaths due to COVID-19, efficacy of first dose of COVID-19 vaccine vs no vaccination on symptoms of patients with long COVID, and the effect of COVID-19 vaccination on long COVID.
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Links for this episode * FDA authorizes over-the-counter at-home test to detect both Influenza and COVID-19 (FDA) * Monoclonal antibody for the prevention of RSV in infants and children (JAMA) * Epidemiologic characteristics of SARS-CoV-2 variant XBB.1.5 (CDC) * COVID-19 vaccines vs pediatric hospitalization (Cell) * Maternal SARS-CoV-2 vaccination and infant protection during the first six months of life (Nature) * Immunoglobulin, glucocorticoid, or combination therapy for MIS in children (The Lancet) * Fatal Fulminant Cerebral Edema in children with SARS-CoV-2 Omicron BA.2 infection (JPID) * Certifying deaths due to COVID-19 (CDC) * Efficacy of first dose of COVID-19 vaccine vs no vaccination on patients with Long COVID (BMJ) * Effect of COVID-19 vaccination on long COVID (BMJ) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin's treatment guide (pdf) * Letters read on TWiV 988 * Don't crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Arturo Casadevall returns to TWiV to explain the use of convalescent serum to treat COVID-19 patients, and the need to support virology at a time when more regulation of experiments is envisioned.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Arturo Casadevall
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Links for this episode * Register for ASV 2023 * MicrobeTV Discord Server * Early treatment of COVID-19 with convalescent plasma (NEJM) * Neutralization of SARS-CoV-2 by convalescent plasma (Nat Comm) * Convalescent COVID-19 plasma for immunocompromised patients (JAMA Net Open) * Virology under the microscope (mSphere) * Virology in peril (mSphere) * Emil von Behring Nobel Lecture * Letters read on TWiV 987 * Timestamps by Jolene. Thanks!
Weekly Picks Rich - Flammarion engraving Alan - What Remains of Edith Finch Vincent - The CDC’s Long-Covid Deception
Listener Pick Bill - General Relativity For Babies
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC’s long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.
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Links for this episode * RSV prefusion F protein vaccine in older adults (NEJM) * Efficacy and safety of an Ad26.RSV.preF–RSV preF protein vaccine (NEJM) * Health care vaccine mandate remains as some push for an end (AP) * Past SARS-CoV-2 infection protection against re-infection (The Lancet) * A third vaccine dose equalizes the levels of effectiveness and immunogenicity of COVID-19 vaccine regimens (medRxiv) * Sotrovimab retains activity against SARS-CoV-2 Omicron variant in primate model (bioRxiv) * Effect of higher-dose Ivermectin for 6 days vs placebo in patients with COVID-19 (JAMA) * Viral burden rebound in patients with COVID-19 receiving oral antivirals (The Lancet) * Serological response to vaccination in post-acute sequelae of COVID (BMC) * Sex differences in cardiovascular complications and mortality in patients with COVID-19 (BMI) * Association of COVID-19 vaccination with risk for incident diabetes after COVID-19 (JAMA) * Postacute sequelae of SARS-CoV-2 in university setting (CDC) * The CDC’s Long-Covid deception (WSJ) * Podcast companies, once walking on air, feel the strain of gravity (NYT) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 986 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern.
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
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Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Marburg virus disease outbreak in Equatorial Guinea (WHO) •Wild-type poliovirus type 3 from laboratory (Eurosurveillance) •Extinct SARS-CoV-2 VOC in white-tailed deer (PNAS) •Letters read on TWiV 985 •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Vibraphone: Lionel Hampton/Gary Burton/Cal Jader. Lionel Hampton: Signature album: The Classics Album Collection, Signature song: Flying Home. Gary Burton: Signature album: A Genuine Tong Funeral. Signature song: General Mojo’s Well Laid Plan. Cal Jader: Signature album: Latin Kick. Signature song: Soul Sauce (Wachi Wara). Milt Jackson (a member of the Modern Jazz Quartet). Signature song: Ice Skating in Central Park. Rich – The American Phage Group: Founders of Molecular Biology by William C. Summers Vincent – DJ Miss Monique aka Olesia Arkusha
Listener Pick Megan – The Day The Music Stopped: How a 1942 recording ban changed America forever and The Weather Channel presents the best of smooth Jazz
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected, lives lost. can society do better, what were the historical reasons for the resistance to recognizing airborne transmission during the COVID-19 pandemic, a randomized trial comparing Omicron-containing boosters with the original COVID-19 vaccine mRNA-1273, SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster, the impacts of SARS-CoV-2 vaccine dose separation and targeting on the COVID-19 epidemic in England, intra-host evolution provides for the continuous emergence of SARS-CoV-2 variants, real-world use of Nirmatrelvir–Ritonavir in outpatients with COVID-19 during the era of Omicron variants including BA.4 and BA.5 in Colorado, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, and guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19.
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Links for this episode * The political polarization of COVID-19 treatments in the United States (PNAS) * Seven alternatives to evidence-based medicine (BMJ) * Malawi’s cholera death toll crosses 1,300 (CBC) * Impact of coronavirus infections on pediatric patients (JHI) * Maternal mRNA COVID-19 vaccination during pregnancy (BMJ) * Yes, masks reduce the risk of spreading COVID (TVO) * COVID-19 and airborne transmission (IDSA) * What were the reasons for resistance to recognizing airborne transmission (IJIE) * Comparing Omicron-containing boosters with COVID-19 vaccine mRNA-1273 (medRxiv) * SARS-CoV-2 neutralizing antibodies after bivalent vs. monovalent booster (bioRxiv) * The impact of SARS-CoV-2 vaccine dose separation and targeting (Nature) * Intra-host evolution provides for the emergence of SARS-CoV-2 variants (ASM) * Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 (The Lancet) * Viral rebound in hospitalized patients with COVID-19 receiving oral antivirals (The Lancet) * Guidance on the use of convalescent plasma to treat immunocompromised patients with COVID-19 (CID) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 984 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guest: Scott Hensley
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Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Multivalent influenza mRNA vaccine (Science) •Influenza virus mRNA vaccines circumvent egg adaptation problems (J Virol) •Letters read on TWiV 983 •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Guitar. Django Reinhardt; Pat Metheny. Signature album: Still Life Talking. Signature song: Last Train Home; Joe Pass (Ella Fitzgerald’s favorite guitar accompanist). Signature album: Virtuoso. Signature song: Round Midnight. Brianne – HHMI Virus Explorer Vincent – Chris Luno
Listener Picks John – White-tail deer density and SARS-CoV-2 in white-tail deer Jessica – Classic cases revisited: Oscar the cat and predicting death
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities, incidence of chronic spontaneous urticaria following receipt of the COVID-19 vaccine booster in Switzerland, relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients, early treatment with pegylated interferon lambda for COVID-19, and how long-term high-dose immunoglobulin successfully treats long COVID patients with pulmonary, neurologic, and cardiologic symptoms.
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Links for this episode * Consistency of COVID-19 trial preprints with published reports (BMI) * Negative effect of preexisting immunity on Influenza vaccine (JID) * Highly pathogenic avian influenza infection in farmed minks (Eurosurveillance) * Peru confirms H5N1 avian flu in marine mammals (CIDRAP) * Prior vaccination enhances immune responses during SARS-CoV-2 infection (bioRxiv) * Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and respiratory infections (CMI) * Incidence of spontaneous Urticaria following COVID-19 vaccine booster (JAMA) * Relationship between immune response to SARS-CoV2 vaccines and breakthrough infection in transplant recipients (CID) * Early treatment with Pegylated Interferon Lambda for COVID-19 (NEJM) * Long-term high-dose immunoglobulin successfully treats Long COVID patients (Frontiers) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 982 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •NSABB proposed oversight framework (pdf) •Stricter US guidelines for research (Nature) •Information on NSABB (NIH) •Consumption of viruses by protists (PNAS) •Letters read on TWiV 981 •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells. Signature song: Sanctified Shells. Conrad Herwig. Signature album: A Jones For Bones Tones. Signature song: Slide’s Routine; Curtis Fuller: Signature album: BLUES ette. Signature song: Bluesette. J.J. Johnson (with Kai Winding). Signature album: The Great Kai and J.J. : Signature song: Monk’s Blues. Kathy – Measles virus ‘cooperates’ with itself to cause fatal encephalitis. Primary research article: Shirogane et al. Rich – Firm hatches plan to bring back dodo (Colossal Biosciences – Dodo) Alan – Mt. Washington Observatory webcam Vincent – Ask the Experts
Listener Picks Roberto – The Contagion of Liberty: The Politics of Smallpox in the American Revolution
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of culturable-virus detection and household transmission of SARS-CoV-2, effectiveness of bivalent boosters against severe Omicron infection, Covid vaccines and playing the long game, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, and severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infections during the pre-Delta, Delta, and Omicron time periods.
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Links for this episode * Prevalence and clinical outcomes of RSV vs influenza in adults (CID) * Reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection (OFID) * Assessment of COVID-19 as the underlying cause of death among children and young people (JAMA) * Information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 infection (CDC) * Association of culturable-virus detection and household transmission of SARS-CoV-2 (JID) * Effectiveness of bivalent boosters against severe Omicron infection (NEJM) * Covid vaccines and playing the long game (NEJM) * Efficacy and safety of antimicrobial stewardship prospective audit and feedback in COVID-19 patients (The Lancet) * Severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infection (CID) * Contribute to our ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 980 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated.
Hosts: Vincent Racaniello and Rich Condit
Guest: Paul Offit
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Links for this episode * FDA briefing document (pdf) * Effectiveness of bivalent booster against severe infection (NEJM) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Nick Muzyczka passes •CDC planning wastewater testing for polio (CDC) •Wastewater testing for poliovirus (MMWR) •NY state poliovirus wastewater surveillance (NYSDOH) •CDC wastewater poliovirus surveillance in select communities (CDC) •Vast world of viroid-like RNAs (Cell) •Timestamps by Jolene. Thanks!
Weekly Picks Kathy – 3B new Milky Way objects, Green comet Rich – Virology under the Microscope—a Call for Rational Discourse Alan – Indie story-driven games series #3: Valiant Hearts: The Great War Vincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf
Listener Picks Florencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article)
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases.
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Links for this episode * Codetections of other respiratory viruses among children with COVID-19 (Pediatrics) * Preprint review should form part of PhD programmes and postdoc training (Nature) * Early and increased Influenza activity among children (CDC) * COVID-19 vaccines versus pediatric hospitalization (Cell) * SARS-CoV-2 variant abnormalities detected by prenatal MRI (The Lancet) * Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity (The Lancet) * Persistent COVID-19 symptoms at 6 months and role of vaccination (JAMA) * Effects of Dexamethasone use among patients with COVID-19 (IJID) * Impact of vaccination on sequelae of SARS CoV-2 in patients with rheumatic diseases (BMJ) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 978 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli
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Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •MicrobeTV Discord Server •Persistence of SARS-CoV-2 (Nature) •Endogenous retroviruses and senescence (Cell) •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song: Bernie’s Tune Angela – World’s Longest Animal Brianne – Green Comet to Pass By Earth for first time in 50,000 years Alan – Indie games series: Golf Club Wasteland Vincent – Bivalent Covid-19 Vaccines — A Cautionary Tale
Listener Picks Lisa – The River and the Wall
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome.
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Links for this episode * China records almost 60,000 COVID-related deaths (SCMP) * Detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool (Nature) * Effect of Fluvoxamine vs placebo in outpatients with COVID-19 (JAMA) * Hyperimmune Globulin for immunocompromised patients with COVID-19 (JID) * Long COVID outcomes at one year after mild infection (BMJ) * Major findings, mechanisms and recommendations for Long COVID (Nature) * Review of trials investigating therapeutic modalities for post-acute COVID-19 (CMI) * Effect of using a structured pacing protocol (JMV) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 976 * Don’t crush Paxlovid (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Daniela Weiskopf
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Links for this episode •Research assistant position at FDA (pdf) •Register for ASV 2023 •Cross reactive T cells to SARS-CoV-2 (Science) •SARS-CoV-2 exposure history and T cell response (Cell Rep Med) •Spike T cells cross- recognize Omicron (Nature) •Ancestral SARS-CoV-2 T cells recognize Omicron (Nature) •NVX-CoV2373 induces T cell responses (J Clin Inves) •Letters read on TWiV 975 •Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Video of viral attachment (based on this article) Alan – Starting a series of innovative indie video games. First up: The Longing. Vincent – The Amy Papers and Calendar for live events
Listener Picks Judy – Innate immune evasion strategies of SARS-CoV-2 Charles – Who’s Talking to Chris Wallace? Season 1, epitope 30: Dr. Anthony Fauci on HBO Max
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses poliovirus returns to New York wastewater, COVID-19 is more widespread in animals than we thought, increasing ventilation reduces SARS-CoV-2 airborne transmission in schools, the use of carbon dioxide monitoring to assess ventilation at a national infectious diseases conference, effectiveness of the bivalent mRNA vaccine in preventing severe COVID-19 outcomes, 7-month duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection, and long COVID outcomes at one year after mild SARS-CoV-2 infection.
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Links for this episode * COVID-19 more widespread in animals than thought (Nat Geo) * Increasing ventilation reduces airborne transmission in schools (Frontiers) * Carbon dioxide monitoring to assess ventilation at a NID conference (CID) * Paxlovid patient eligbiliity screening checklist (FDA) * Effectiveness of bivalent mRNA vaccine in preventing severe COVID-19 (Lancet) * Duration of SARS-CoV-2 mucosal immunoglobulin-A responses and protection (Lancet) * Long COVID outcomes at one year after mild SARS-CoV-2 infection (BMJ) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 974 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Felicia joins TWiV to discuss her career and her research on human cytomegalovirus, which infects most of us for our entire lives yet mainly causes disease in the immunosuppressed.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Felicia Goodrum
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Links for this episode •Research assistant position at FDA (pdf) •The loss of binary (Curr Clin Micro Rep) •Virology in Peril (mBio) •Letters read on TWiV 973 •Timestamps by Jolene. Thanks!
Weekly Picks Brianne – “Leukocyte” immunology video parody Alan – West Point Removing Confederate Monuments, and Ty Seidule’s book on that subject Vincent – The works of Haruki Murakami – South of the Border, West of the Sun; also short stories (First Person Singular, particularly Confessions of a Shinagawa Monkey; and Men Without Women, particularly Drive My Car)
Listener Picks Karen – On All Fours: Transient Laborers, the Threat of Movement, and the Aftermath of Disease Kevin – James Hoffmann and Bald and Bankrupt
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case.
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Links for this episode * Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature) * Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv) * Antibody evasion properties of BQ and XBB subvariants (Cell) * Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature) * Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI) * Paxlovid patient eligbiliity screening checklist (FDA) * COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature) * Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell) * SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature) * Long-term cardiovascular outcomes of COVID-19 (Nature) * Heart-disease risk soars after COVID (Nature) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 972 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
In the first epitope of 2023, TWiV reviews our coverage of virology in 2022, including favorite story arcs, episodes, show titles, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode Our favorite 2022 virology stories: •Vincent: Paul Offit on bivalent boosters (TWiV 917, 942, Special) •Dickson: Interviews with Paul Offit and Andy Slavitt •Rich: TWiV 948: Breathless with David Quammen •Kathy: TWiV 915: Mouse mouth to mouse mom •Brianne: Spillovers (TWiV 923 and 876) •Vincent: Giant viruses (TWiV 873, 906, 968) •Dickson: TWiV 960 – Getting Funky with Dan Wilson •Rich: TWiV 927: Merchlinsky vs monkeypox •Kathy: TWiV 958: Pass the RNA and have some venison pi •Brianne: TWiV 869: Epstein-Barr virus and MS, a perfect storm •Twiverse •Letters read on TWiV 968 •Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Tenor saxophone: John Coltrane/Dexter Gordon/Stan Getz: John Coltrane: Signature album: Giant Steps: Signature song: Blue Train; Dexter Gordon: Signature album: The Other Side Of Round Midnight. Signature song: Round Midnight; Stan Getz (with Charlie Byrd on guitar): Signature Album: Jazz Samba; Signature song: Desafinado Brianne –A Full Circle Rainbow over Norway Kathy – Frozen soap bubbles Rich – It’s Turtles All the Way Down in the Fossil Record by Asher Elbein Vincent – Vincent’s Top Ten Music
Listener Picks Charles – Wayne Bergeron and Vince DiMartino MacArthur Park
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses modelling the adjustment of COVID-19 response and exit from dynamic zero-COVID in China, canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event, two masks can be worse than one: N95 respirator failure caused by an overlying face mask, airflow patterns in double-occupancy patient rooms may contribute to roommate-to-roommate transmission of severe SARS-CoV-2, clinical validation of a novel T-Cell receptor sequencing assay for identification of recent or prior SARS-CoV-2 infection, antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera, regardless of the infecting variant, VV116 versus Nirmatrelvir–Ritonavir for oral treatment of Covid-19, Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support, FDA approves Roche’s Actemra (tocilizumab) for the treatment of COVID-19 in hospitalized adults, structural brain changes in post-acute COVID-19 patients with persistent olfactory dysfunction, persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium, epidemiology of long COVID in US adults, persistent symptoms and sequelae after SARS-CoV-2 infection not requiring hospitalization, and outpatient treatment of Covid-19 with metformin, ivermectin, and fluvoxamine and the development of Long Covid over 10-month follow-up.
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Links for this episode * Modeling the adjustment of COVID-19 response and exit in China (Nature) * Canine real-time detection of SARS-CoV-2 infections in mass screening events (BMJ) * N95 respirator failure caused by an overlying face mask (ICHE) * Airflow in patient rooms may contribute to transmission of severe SARS-CoV-2 (CID) * Clinical validation of a T-Cell receptor for identification of recent or prior SARS-CoV-2 infection (CID) * Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages (Cell) * VV116 vs. Nirmatrelvir–Ritonavir for oral treatment of Covid-19 (NEJM) * Nirmatrelvir plus Ritonavir for early COVID-19 in a U.S. health system (ACP) * Molnupiravir as early treatment for adults with COVID-19 (The Lancet) * Higher dose corticosteroids in hospitalized COVID-19 patients with hypoxia but not requiring ventilatory support (medRxiv) * FDA approves Tocilizumab for the treatment of COVID-19 in hospitalized adults (Roche) * Structural brain changes in post-acute COVID-19 patients with olfactory dysfunction (Annals) * Paxlovid patient eligbiliity screening checklist (FDA) * Persistent post–COVID-19 smell loss association (Science) * Epidemiology of long COVID in US adults (CID) * Persistent symptoms & sequelae after SARS-CoV-2 infection not requiring hospitalization (OFID) * Outpatient treatment of COVID-19 with metformin, ivermectin, and fluvoxamine & the development of long COVID (medRxiv) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 970 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Carl Zimmer visits the Incubator to record a wide-ranging conversation about COVID-19, including origins, vaccines, public health responses, and impact on society.
Host: Vincent Racaniello
Guest: Carl Zimmer
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Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
TWiV reviews eukaryotic viruses recovered from ancient permafrost, a mistake made by scientists on Omicron origins, and close relatives of MERS-CoV from bats that bind ACE2 for entry into cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * Positions with the Mosquito and Vector Control Division in Harris County Public Health (one and two) * Ancient eukaryotic viruses from permafrost (bioRxiv) * We made a mistake (Science) * Bat MERS-like CoV bind ACE2 (Nature) * Letters read on TWiV 968 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Alto Saxophone: Paul Desmond/Cannonball Adderley/Charlie Parker/Randal Despommier: Paul Desmond: Signature album: Paul Desmond:The Complete RCA Victor Recordings (1961-1965). Signature song: Take Five (Dave Brubeck Quartet). Cannonball Adderley: Signature album: The Cannonball Adderley Quintet: Mercy, Mercy, Mercy. Signature song: Mercy, Mercy, Mercy. Charlie Parker (Bird): played in many groups: Signature album: Dizzy Gillespie and His Allstars. Signature song: A Night In Tunisia; Randal Despommier: Signature album: A Midsummer Odyssey. Signature song: I Hope It’s Spring For You. Brianne – How a See-Through Frog Hides its Red Blood from Predators (also covered in The Atlantic) Rich – Mindfulness in Plain English by Ven. Henepola Gunaratana Vincent – Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
Listener Picks Rona – WKCR, FM 89.9 Columbia‘s radio station Alan – XKCD Proxy Variable
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses how immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection, prevalence of SARS-CoV-2 and influenza coinfection and clinical characteristics among children and adolescents aged
Vincent travels to the NIH campus to speak with Jeffery Taubenberger about his career, the 1918 influenza pandemic, deciphering the genome sequence of the virus from tissues of disease victims and using it to rescue infectious virus.
Host: Vincent Racaniello
Guest: Jeffery Taubenberger
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * Influenza 1918 pandemic questions answered (Sci Transl Med) * Reconstructed 1918 influenza virus (Science) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Brazilian infectious diseases physician Esper Kallas returns to TWiV to discuss the state of viral diseases in his country, including those cause by Zika, dengue, and yellow fever viruses, MPOX, and SARS-CoV-2.
Hosts: Vincent Racaniello and Alan Dove
Guest: Esper Kallas
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info) * Viral kinetics in sylvatic yellow fever (J Inf Dis) * Safety and efficacy of Butanan-DV (Lancet Inf Dis) * Immune responses to CoronaVac (Front Immunol) * Timestamps by Jolene. Thanks!
Weekly Picks Alan – A Voyage for Madmen Vincent – Some favorite holiday cookies: pignoli cookies and pfeffernusse
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses Dr. Griffin discusses progress toward poliomyelitis eradication in Afghanistan, reduced risk for Mpox after receipt of 1 or 2 doses of JYNNEOS vaccine compared with risk among unvaccinated persons, reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters, authorized updated (Bivalent) COVID-19 vaccines for children down to 6 months of age, low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine or a BA.5-bivalent booster, efficacy of antiviral agents against omicron subvariants BQ.1.1 and XBB, incidence of viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir, and the effectiveness of coronavirus disease 2019 (COVID-19) vaccine in the prevention of post–COVID-19 conditions.
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Links for this episode * Progress toward Poliomyelitis eradication in Afghanistan (CDC) * Reduced risk for Mpox after receipt of 1 or 2 Doses of JYNNEOS vaccine (CDC) * Reduced airborne transmission of BA.1 Omicron virus in Syrian hamsters (PLOS) * Authorized bivalent vaccines for children down to 6 months of age (FDA) * Low neutralization of BA.2.75.2, BQ.1.1, and XBB.1 by parental mRNA vaccine (Nature) * Efficacy of antiviral agents against Omicron subvariants BQ.1.1 and XBB (NEJM) * Viral rebound after treatment with Nirmatrelvir-Ritonavir and Molnupiravir (JAMA) * Paxlovid patient eligbiliity screening checklist (FDA) * Effectiveness of COVID-19 vaccines in prevention of post–infection conditions (ASHE) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 964 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to Cornell University to speak with Gary Whittaker about regulation by proteolytic processing of the fusion activity of the spike protein of SARS-CoV-2, and feline coronavirus transmission, replication and disease.
Hosts: Vincent Racaniello
Guest: Gary Whittaker
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Links for this episode * SARS-CoV-2 spike and its furin cleavage site (Lancet Microbe) * TMPRSS2 inhibitor blocks SARS-CoV-2 reproduction (Nature) * Distinct spike proteins of feline coronaviruses (Viruses) * Feline coronavirus and feline infectious peritonitis (J Zoo Wild Med) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Paul Offit returns to TWiV to discuss why the bivalent booster dosing story should be a cautionary tale of how not to move forward in this pandemic.
Hosts: Vincent Racaniello and Rich Condit
Guest: Paul Offit
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Links for this episode * Antibody responses to bivalent booster (bioRxiv) * Immunogenicity of bivalent vaccine (bioRxiv) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
Astrophysicist Chiara Mingarelli joins TWiV to discuss her career and her work using pulse timing arrays to study the gravitational wave background, ripples in the fabric of spacetime that are caused by events such as the merging of black holes.
Hosts: Vincent Racaniello, Rich Condit, and Angela Mingarelli
Guest: Chirara Mingarelli
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info) * Seeing the gravitational wave universe (Science) * Timestamps by Jolene. Thanks!
Weekly Picks Angela – OpenAI Playground and Nature Milestones: T cells Chiara – The Biggest Ideas in the Universe by Sean Carroll Kathy – Recycling PVC and here and here Rich – Brome Bird Care Squirrel Buster Plus (Bonus pick: 1971 Volvo 142 Commercial – With John Cameron Swayze) Vincent – Journey to the Microcosmos
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses Mpox (formerly monkeypox) in women: epidemiological features and clinical characteristics of mpox cases in Spain, April to November 2022, triage of patients with Ebola virus disease, SARS-CoV-2 serology and self-reported infection among adults, serological markers of SARS-CoV-2 infection; anti-nucleocapsid antibody positivity may not be the ideal marker of natural infection in vaccinated individuals, sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody for breakthrough infections during the epidemic of the Omicron variants, effect of wearing glasses on risk of infection with SARS-CoV-2 in the community, and data-driven identification of post-acute SARS-CoV-2 infection subphenotypes.
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Links for this episode * Mpox in women: Epidemiological features and clinical characteristics of cases (Eurosurveillance) * Triage of patients with Ebola virus disease (The Lancet) * SARS-CoV-2 serology and self-reported infection among adults (CDC) * Serological markers of SARS-CoV-2 infection (JID) * Sensitivity of anti-SARS-CoV-2 nucleocapsid protein antibody (Journal of infection) * Effect of wearing glasses on risk of infection with SARS-CoV-2 in the community (JAMA) * Paxlovid patient eligbiliity screening checklist (FDA) * Data-driven identification of post-acute SARS-CoV-2 infection subphenotypes (Nature) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 961 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv
Dan Wilson of Debunk the Funk joins TWiV to explain why he decided to take on science misinformation and how he critiques people who promulgate incorrect information.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Dan Wilson
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * International Scientific Coordinator Position (agajewski at icsnicaragua.org for more info) * Debunk the Funk (YouTube) * Letters read on TWiV 960 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: InstrumentalTrumpet: Clifford Brown/Miles Davis/Winton Marsalis. Clifford Brown: Signature album: Study In Brown, Signature song: Sandu; Miles Davis: Signature albums: Kind Of Blue; Sketches Of Spain; Porgy And Bess; Miles. Signature song: Time After Time. Wynton Marsalis: Signature album: Standard Time. Signature song: Do You Know What It Means To Miss New Orleans
Brianne – Physicists Create a Wormhole
Rich – Dec 1 APOD: Artemis 1 Flight Day 13
Vincent – An Ancient Language, Once on the Brink, Is a British Isle’s Talk of the Town
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses effectiveness of influenza vaccination of pregnant women for prevention of maternal and early infant Influenza-associated hospitalizations in South Africa, a multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes, single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic induce durable B cell memory responses comparable to replicating smallpox vaccines, whether the risk of still and preterm birth is affected by the timing of symptomatic SARS-CoV-2 infection during pregnancy, medical masks versus N95 respirators for preventing COVID-19 among health care workers, alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, real-world evidence of novel treatments for COVID-19 on mortality: a nationwide comparative cohort study of hospitalized patients in the 1st, 2nd, 3rdand 4th wave in the Netherlands, and effectiveness and safety of extended thromboprophylaxis in post-discharge patients with COVID-19.
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Links for this episode * Effectiveness of Influenza vaccination in pregnant women (OFID) * Multivalent nucleoside-modified mRNA vaccine against Influenza subtypes (Science) * Single and 2-dose vaccinations with modified vaccinia Ankara-Bavarian Nordic (JID) * Is the risk of still and preterm birth affected by the timing of symptomatic SARS-CoV-2 infection? (AJOG) * Medical masks versus N95 respirators for preventing COVID-19 among health care workers (ACP) * Bebtelovimab fact sheet for providers (FDA) * Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants (bioRxiV) * Paxlovid patient eligbiliity screening checklist (FDA) * Real-world evidence of novel treatments for COVID-19 on mortality (OFID) * Effectiveness and safety of extended thromboprophylaxis in post-discharge patients with COVID-19 (Thrombosis Research) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 959 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The TWiV team reveals a variant SARS-CoV-2 that emerged in deer with deer-to-human transmission, and hybrid virus particles produced by co-infection with influenza virus and respiratory syncytial virus particles.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * Testing and evaluation specialist (Harris County Public Health) * Oveta Fuller tribute (YouTube) * Divergent SARS-CoV-2 in deer (Nat Micro) * Hybrid influenza virus and respiratory syncytial virus particles (Nat Micro) * Letters read on TWiV 958 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz Project: Vocals
Best female vocalists: Ella Fitzgerald/Billie Holiday, Betty Carter
Best Male Vocalists: Mel Tormé/Joe Williams/Tony Bennett
Brianne – ASV Curriculum Guidelines for Virology Courses
Kathy – The Snow Cruiser
Alan – Rescuing bats in Ukraine
Vincent – Pasta Grammar
Listener Picks Florencia – World of Viruses
Miguel – Foldscope
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospitalization rate among adults with COVID-19, inside the mind of an anti-paxxer, and angiotensin receptor blockers for the treatment of COVID-19.
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Links for this episode * Human monkeypox virus infection in women and non-binary individuals (The Lancet) * Changes in population immunity against infection and severe disease from variants (Medrxiv) * Updates on COVID-19 related mortality (CDC) * Impact of community masking on COVID-19 (Science) * Effectiveness of the COVID-19 vaccines against hospitalization (The Lancet) * Cardiovascular outcomes after tixagevimab and cilgavimab use for pre-exposure prophylaxis (CID) * Bebtelovimab fact sheet for providers (FDA) * Paxlovid associated with decreased hospitalization among adults (CDC) * Inside the mind of an Anti-Paxxer (The Atlantic) * Paxlovid patient eligbiliity screening checklist (FDA) * Angiotensin receptor blockers for the treatment of COVID-19 (BMJ) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 957 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Cedric and John join TWiV to discuss their research showing that a human protein derived from an ancient retrovirus infection can protect against infection by other retroviruses.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Cedric Feschotte and John Anthony Frank
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * Cedric on TWiV 935 * Antiviral retroviral protein (Science) * Stealing genes, facing consequences (Science) * Letters read on TWiV 956 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Wastewater Dashboard
Rich – Artemis I Mission; Artemis I launch; Artemis I Map
Vincent – Pasta Grammar
Listener Picks Rich – Watch a virus in the moments before it attacks
Justin – Respiratory syncytial virus
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses the four things to know about RSV, the burden of respiratory syncytial virus in healthy term-born infants in Europe, the diagnostic accuracy of rapid diagnostic tests for Ebola virus disease, evaluating the accuracy of self-collected swabs for the diagnosis of monkeypox, tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations, acute and postacute sequelae associated with SARS-CoV-2 reinfection, clinical course of SARS-CoV-2 infection and recovery in lung transplant recipients, effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy, maternal antibody response and transplacental transfer following SARS-CoV-2 infection or vaccination in pregnancy, impact of community masking on COVID-19, Lifting Universal Masking in Schools – Covid-19 Incidence among Students and Staff, systematic review of the clinical effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 in immunocompromised patients, comparative effectiveness of sotrovimab and molnupiravir for prevention of severe COVID-19 outcomes in patients in the community, early adoption of anti–SARS-CoV-2 pharmacotherapies among us veterans with mild to moderate COVID-19, evaluation of viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants, monoclonal antibodies for treatment of SARS-CoV-2 infection during pregnancy, twice daily oral zinc in the treatment of patients with COVID-19, cognitive deficits in long Covid-19, severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration, and long-lasting symptoms after an acute COVID-19 infection and factors associated with their resolution.
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Links for this episode * Four things to know about RSV (Gates Foundation) * The burden of RSV in healthy term-born infants in Europe (The Lancet) * Diagnostic accuracy of rapid tests for Ebola (CMI) * Accuracy of self-collected swabs for diagnosis of Monkeypox (CID) * Tecovirimat is effective against human monkeypox virus in vitro (Nature) * Acute and postacute sequelae associated with SARS-CoV-2 reinfection (NatureMedicine) * SARS-CoV-2 infection and recovery in lung transplant recipients (Transplant Infectious Diseases) * Effectiveness of third COVID-19 vaccination during pregnancy (Nature Communications) * Maternal antibody response and transplacental transfer following infection or vaccination (CID) * Impact of community masking on COVID-19 (Science) * Lifting universal masking in schools (NEJM) * Bebtelovimab fact sheet for providers (FDA) * Effectiveness of Tixagevimab/Cilgavimab for prophylaxis of COVID-19 (medRxiv) * Effectiveness of Sotrovimab and Molnupiravir for prevention of severe COVID-19 outcomes (BMJ) * Early adoption of Anti–SARS-CoV-2 pharmacotherapies among US veterans (JAMA) * PAXLOVID patient eligibility screening checklist (FDA) * Viral and symptom rebound differences between Paxlovid and untreated COVID-19 participants (medRxiv) * Monoclonal antibodies for treatment of SARS-CoV-2 during pregnancy (Annals of Internal Medicine) * Remdesivir fact sheet for providers (Veklury) * Twice daily oral zinc in the treatment of patients with COVID-19 (CID) * Cognitive deficits in long COVID-19 (NEJM) * Severe Neuro-COVID associated with peripheral immune signatures, autoimmunity and neurodegeneration (Nature Communications) * Long-lasting symptoms after an acute COVID-19 Infection (JAMA) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 955 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Michael Letko joins TWiV to discuss his research on understanding cell receptors required for sarbecovirus entry, including an ACE2-dependent isolate from Russian bats that is resistant to vaccine-induced antibodies.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Michael Letko
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Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) with promo code MicrobeTV * Cell entry of SARS-CoV-2 and other sarbecoviruses (Nat Micro) * ACE2-dependent sarbecovirus in Russian bats (PLoS Path) * Letters read on TWiV 954 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Sometimes This Octopus is So Mad it Just Wants to Throw Something or The Cosmic Bat Nebula
Kathy – APODs Jupiter, Lunar Eclipse Blood Moon, Ice Giant
Rich – Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs (Wiki: Mirror Life)
Vincent – The 2022-2023 Respiratory Virus Season Hits Early and Hard: Part 1
Listener Pick Debby – Celebrate Bob McDonald’s 30 years as host of Quirks & Quarks
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses high demand for Amoxicillin causing shortages amid child RSV surge, epidemiologic and clinical features of children and adolescents aged <18 years with monkeypox, low risk of SARS-Cov-2 transmission by fomites, nucleocapsid antigenemia is a marker of acute SARS-CoV-2 infection, impact of community masking on COVID-19, protection against Omicron from vaccination and previous infection in a prison system, Nirmatrelvir and the risk of post-acute sequelae of COVID-19, Bebtelovimab for high-risk outpatients with early COVID-19 in a large US health system, imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution, can SARS-CoV-2 trigger new onset of autoimmune disease in adults? A case-based review, and retrospectively modeling the effects of increased global vaccine sharing on the COVID-19 pandemic.
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Links for this episode * High demand for Amoxicillin causing shortages amid RSV surge (Washington Post) * Epidemiologic and clinical features of children & adolescents with monkeypox (CDC) * Low risk of SARS-Cov2 transmission by fomites (IDSA) * Nucleocapsid Antigenemia Is a marker of acute SARS-CoV-2 Infection (JID) * Impact of community masking on COVID-19 (Science) * Remdesivir fact sheet for providers (Veklury) * Protection against Omicron from vaccination & previous infection in prison system (NEJM) * Nirmatrelvir and the risk of post-acute sequelae of COVID-19 (medRxiv) * Bebtelovimab for high-risk outpatients with COVID-19 (OFID) * Imprinted SARS-CoV-2 immunity induces convergent Omicron evolution (bioRxiv) * PAXLOVID patient eligibility screening checklist (FDA) * Can SARS-CoV-2 trigger new onset of autoimmune disease in adults? (Cell) * Bebtelovimab fact sheet for providers (FDA) * Modeling the effects of global vaccine sharing on the COVID-19 pandemic (Nature) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 953 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jake Scott
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Links for this episode * Omicron variant reproduction ex vivo (Nature) * Clinical outcomes with Omicron (Nat Med) * Low neutralizing antibodies induced by bivalent booster (NEJM) * Antibody responses to bivalent booster (bioRxiV) * Spike T cell responses not enhanced by bivalent booster (Sci Immunol) * Pandemic end will not be televised (BMJ) * Conflation of infection and disease (Twitter) * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez
Rich – Wilderness Safaris Photographic Competition 2022
Alan – Massachusetts Science Education Leadership Association, and the talk I gave to them last week
Vincent – Andrea Camillieri and his protagonist Inspector Montalbano
Listener Pick Frank – Economics for the Future: Beyond the Superorganism
Debby – As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Infectious Disease physician Jake Scott joins TWiV to provide a west coast clinical perspective on the evolution of the COVID-19 pandemic with respect to the impact of vaccines, antivirals, variants of concern and mortality.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jake Scott
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Omicron variant reproduction ex vivo (Nature) * Clinical outcomes with Omicron (Nat Med) * Low neutralizing antibodies induced by bivalent booster (NEJM) * Antibody responses to bivalent booster (bioRxiV) * Spike T cell responses not enhanced by bivalent booster (Sci Immunol) * Pandemic end will not be televised (BMJ) * Conflation of infection and disease (Twitter) * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – 10 moments for Jazz at Lincoln Center Orchestra Residency (Item 7) and Alan’s pick from TWiV 931 The Kissing Bug by Daisy Hernandez
Rich – Wilderness Safaris Photographic Competition 2022
Alan – Massachusetts Science Education Leadership Association, and the talk I gave to them last week
Vincent – Andrea Camillieri and his protagonist Inspector Montalbano
Listener Pick Frank – Economics for the Future: Beyond the Superorganism
Debby – As routine vaccination rates fall, polio survivor hopes her story reverses urgent trend
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Influenza incidence and vaccine effectiveness (CDC) * Nirsevimab for prevention of RSV (NEJM) * Severe Monkeypox in hospitalized patients (CDC) * Reinfections with different SARS-CoV-2 Omicron subvariants (CDC) * Impact of community masking on COVID-19 (Science) * Vaccine elicits protective immunity against sarbecoviruses (Science) * Antibody responses to bivalent mRNA vaccine booster shot (Biorxiv) * Immunogenicity of bivalent mRNA vaccine boosters (Biorxiv) * Long-term gastrointestinal sequelae following COVID-19 (CGH) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Evaluation of an automated text message–based program (JAMA) * Melatonin assessed for effects on inflammatory markers in COVID patients (Heliyon) * PAXLOVID patient eligibility screening checklist (FDA) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin's treatment guide (pdf) * Letters read on TWiV 951 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses Influenza incidence and vaccine effectiveness during the southern hemisphere influenza season in Chile, Nirsevimab for prevention of RSV infection in healthy late-preterm and term infants, severe Monkeypox in hospitalized patients, reinfections with different SARS-CoV-2 Omicron subvariants, impact of community masking on COVID-19 in Bangladesh, unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses, antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot, immunogenicity of bivalent mRNA vaccine boosters, long-term gastrointestinal sequelae following COVID-19, evaluation of an automated text message–based program to reduce use of acute health care resources after hospital discharge, and how in adults with COVID-19, melatonin was assessed for effects on inflammatory markers, clinical signs and symptoms, and mortality.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Influenza incidence and vaccine effectiveness (CDC) * Nirsevimab for prevention of RSV (NEJM) * Severe Monkeypox in hospitalized patients (CDC) * Reinfections with different SARS-CoV-2 Omicron subvariants (CDC) * Impact of community masking on COVID-19 (Science) * Vaccine elicits protective immunity against sarbecoviruses (Science) * Antibody responses to bivalent mRNA vaccine booster shot (Biorxiv) * Immunogenicity of bivalent mRNA vaccine boosters (Biorxiv) * Long-term gastrointestinal sequelae following COVID-19 (CGH) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Evaluation of an automated text message–based program (JAMA) * Melatonin assessed for effects on inflammatory markers in COVID patients (Heliyon) * PAXLOVID patient eligibility screening checklist (FDA) * Contribute to our MicrobeTV fundraiser at PWB * Dr. Griffin's treatment guide (pdf) * Letters read on TWiV 951 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.
Host: Vincent Racaniello
Guest: Richard Knight
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Links for this episode * National CJD Research and Surveillance Unit * Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci) * Variant Creutzfeldt-Jakob disease (Handbook Clin Viral) * Creutzfeldt-Jakob disease (Adv Exp Med Biol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans.
Host: Vincent Racaniello
Guest: Richard Knight
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * National CJD Research and Surveillance Unit * Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci) * Variant Creutzfeldt-Jakob disease (Handbook Clin Viral) * Creutzfeldt-Jakob disease (Adv Exp Med Biol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Progress toward Poliomyelitis eradication (CDC) * Polio by the numbers (JID) * Influenza & COVID-19 vaccination coverage among health care personnel (CDC) * Phase 1/2a Safety & Immunogenicity of an adenovirus RSV Vaccine (JID) * Receipt of first & second doses of JYNNEOS vaccine (CDC) * Distinguishing SARS-CoV-2 persistence and reinfection (CID) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Novavax triggers potent neutralization of Omicron sub-lineages (bioRxiV) * Association between physical activity & vaccination protective effect (BMJ) * PAXLOVID patient eligibility screening checklist (FDA) * COVID-19 outcomes in solid organ transplant recipients who received monoclonal antibodies (Transplantation) * Omicron BA.2.75.2 exhibits escape from neutralizing antibodies (bioRxiV) * Tocilizumab vs. Baricitinib in hospitalized patients with severe COVID-19 (CMI) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 949 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity and the protective effect of vaccination against SARS-CoV-2 in a South African case, COVID-19 outcomes in solid organ transplant recipients who received Tixagevimab-cilgavimab Prophylaxis and/or Bebtelovimab treatment, Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralizing antibodies, and Tocilizumab versus Baricitinib in hospitalized patients with severe COVID-19.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Progress toward Poliomyelitis eradication (CDC) * Polio by the numbers (JID) * Influenza & COVID-19 vaccination coverage among health care personnel (CDC) * Phase 1/2a Safety & Immunogenicity of an adenovirus RSV Vaccine (JID) * Receipt of first & second doses of JYNNEOS vaccine (CDC) * Distinguishing SARS-CoV-2 persistence and reinfection (CID) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Novavax triggers potent neutralization of Omicron sub-lineages (bioRxiV) * Association between physical activity & vaccination protective effect (BMJ) * PAXLOVID patient eligibility screening checklist (FDA) * COVID-19 outcomes in solid organ transplant recipients who received monoclonal antibodies (Transplantation) * Omicron BA.2.75.2 exhibits escape from neutralizing antibodies (bioRxiV) * Tocilizumab vs. Baricitinib in hospitalized patients with severe COVID-19 (CMI) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 949 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: David Quammen
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Links for this episode * Boston Quammens (TWiV 408) * Breathless by David Quammen * Spillover by David Quammen * Song of the Dodo by David Quammen * Timestamps by Jolene. Thanks!
Weekly Picks David – Shepherd
Brianne – Adventure Aquarium
Kathy – DART results (Narrative, images)
Rich – “Elementary” TV series
Vincent – Stop passing the buck on intro science
Listener Pick Rich – Consensus
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
David Quammen returns to TWiV to discuss how he wrote his new book ‘Breathless’, a story about the science and the scientists behind the race to understand the pandemic coronavirus SARS-CoV-2.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: David Quammen
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Boston Quammens (TWiV 408) * Breathless by David Quammen * Spillover by David Quammen * Song of the Dodo by David Quammen * Timestamps by Jolene. Thanks!
Weekly Picks David – Shepherd
Brianne – Adventure Aquarium
Kathy – DART results (Narrative, images)
Rich – “Elementary” TV series
Vincent – Stop passing the buck on intro science
Listener Pick Rich – Consensus
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Prediction of upcoming global infection burden of Influenza (The LANCET) * Severe COVID-19 outcomes after full vaccination (The LANCET) * Successful immunomodulators for treatment of COVID-19 (CMI) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * PAXLOVID patient eligibility screening checklist (FDA) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 947 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses the prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic, severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters, and how successful immunomodulators for treatment of COVID-19 have opened the pathway for comparative trials.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Prediction of upcoming global infection burden of Influenza (The LANCET) * Severe COVID-19 outcomes after full vaccination (The LANCET) * Successful immunomodulators for treatment of COVID-19 (CMI) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * PAXLOVID patient eligibility screening checklist (FDA) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 947 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Angela Mingarelli
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Bat gut microbiota and flu infection in mice (Transbound Emerg Dis) * Primate hemorrhagic fever-causing arteriviruses (Cell) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz pics: #5. Small group. Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March
Brianne – Why Chimps and Gorillas Form Rainforest Friendships
Rich – Fly Water – FPV to New Depths
Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions
Angela – Nature’s Inspiring Women in Science Award
Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Angela Mingarelli joins TWiV to discuss whether the gut microbiota of bats confers tolerance to influenza virus infection in mice, and primate hemorrhagic fever-causing arteriviruses that can reproduce in human cells and might be capable of infecting humans.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Angela Mingarelli
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Bat gut microbiota and flu infection in mice (Transbound Emerg Dis) * Primate hemorrhagic fever-causing arteriviruses (Cell) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz pics: #5. Small group. Art Blakey and the Jazz Messenger: Art Blakey, Drums; Lee Morgan, Trumpet; Benny Golson, Tenor saxophone; Bobby Timmons, Piano; Jymie Merrit, Bass (1958-1964). Signature album: Art Blakey And The Jazz Messengers: Blues March: Signature song: Blues March
Brianne – Why Chimps and Gorillas Form Rainforest Friendships
Rich – Fly Water – FPV to New Depths
Alan – The Seven Words You Can’t Say on Television, by George Carlin, and its repercussions
Angela – Nature’s Inspiring Women in Science Award
Vincent – Mysteries of Nevada Barr and her protagonist Anna Pigeon
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position with Amy Rosenfeld (pdf) * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * A healthcare-associated infection with monkeypox virus (OFID) * Air and surface sampling for monkeypox virus (The Lancet) * Misrepresentation & nonadherence in COVID-19 public health measures (JAMA) * Tolerability and immunogenicity of a COVID-19 vaccine (The Lancet) * PAXLOVID patient eligibility screening checklist (FDA) * Evaluation of symptomatic disease rebound following PAXLOVID (CID) * Outpatient treatment with Remdesivir in patients at high risk (OFID) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Molnupiravir as early treatment for adults with COVID-19 (SSRN) * Outcomes among confirmed cases and matched comparison group in long-COVID (Nature) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 945 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses a healthcare-associated infection with Monkeypox virus, air and surface sampling for monkeypox virus in a UK hospital, misrepresentation and nonadherence regarding COVID19 public health measures, tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine, clinical, virologic, and immunologic evaluation of symptomatic rebound following Nirmatrelvir/Ritonavir treatment, early outpatient treatment with Eemdesivir in patients at high risk for severe COVID-19, Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes, and outcomes among confirmed cases and a matched comparison group in the long-COVID in Scotland.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position with Amy Rosenfeld (pdf) * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * A healthcare-associated infection with monkeypox virus (OFID) * Air and surface sampling for monkeypox virus (The Lancet) * Misrepresentation & nonadherence in COVID-19 public health measures (JAMA) * Tolerability and immunogenicity of a COVID-19 vaccine (The Lancet) * PAXLOVID patient eligibility screening checklist (FDA) * Evaluation of symptomatic disease rebound following PAXLOVID (CID) * Outpatient treatment with Remdesivir in patients at high risk (OFID) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Molnupiravir as early treatment for adults with COVID-19 (SSRN) * Outcomes among confirmed cases and matched comparison group in long-COVID (Nature) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 945 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Kathryn Hanley
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * One bite is all it takes (TWiV 587) * CREATE-NEO * Shifts in Borneo mosquito diversity (Ecosphere) * VSV surveillance along Rio Grande (PLoS Path) * Virulence a trade-off between transmission and clearance (Viruses) * West Nile virus disease indicators (Viruses) * Identify mosquito meals by barcoding (Trop Med Inf Dis) * SkitoSnack (Sci Rep) * Neal Nathanson dies (Baltimore Sun) * VRR interview with Neal Nathanson (YouTube) * Letters read on TWiV 944 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Car Talk Puzzler Archive
Rich – The Molecular Biologist Who Exposed the Soviet Union” by Sean B. Carroll
Vincent – NYU Chemistry prof fired because his course was too difficult
Listener Pick Jack – The Everything Virus
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Kathryn Hanley
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * One bite is all it takes (TWiV 587) * CREATE-NEO * Shifts in Borneo mosquito diversity (Ecosphere) * VSV surveillance along Rio Grande (PLoS Path) * Virulence a trade-off between transmission and clearance (Viruses) * West Nile virus disease indicators (Viruses) * Identify mosquito meals by barcoding (Trop Med Inf Dis) * SkitoSnack (Sci Rep) * Neal Nathanson dies (Baltimore Sun) * VRR interview with Neal Nathanson (YouTube) * Letters read on TWiV 944 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Car Talk Puzzler Archive
Rich – The Molecular Biologist Who Exposed the Soviet Union” by Sean B. Carroll
Vincent – NYU Chemistry prof fired because his course was too difficult
Listener Pick Jack – The Everything Virus
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position with Amy Rosenfeld (pdf) * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Multi-National Monkeypox outbreak (CDC) * Mutation of the Monkeypox Virus (Nature) * Occupational infection of Healthcare workers with Monkeypox (CDC) * Rates of Monkeypox cases by vaccination status (CDC) * Protection of SARS-CoV-2 natural infection against reinfection (CMI) * PAXLOVID patient eligibility screening checklist (FDA) * Paxlovid reduces COVID19 hospitalizations & deaths (EPIC) * Paxlovid rebound in COVID19 (NEJM) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 943 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position with Amy Rosenfeld (pdf) * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Multi-National Monkeypox outbreak (CDC) * Mutation of the Monkeypox Virus (Nature) * Occupational infection of Healthcare workers with Monkeypox (CDC) * Rates of Monkeypox cases by vaccination status (CDC) * Protection of SARS-CoV-2 natural infection against reinfection (CMI) * PAXLOVID patient eligibility screening checklist (FDA) * Paxlovid reduces COVID19 hospitalizations & deaths (EPIC) * Paxlovid rebound in COVID19 (NEJM) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 943 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.
This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.
Laurie Garrett and Vincent Racaniello
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Coliform testing of water in Florida (YouTube) * Declining cost of genome sequencing (Illumina) * National wastewater surveillance system (CDC) * Advances in detection of viruses in wastewater (Med Express) * Wastewater monitoring comes of age (Nature) * Monitoring monkeypox virus in wastewater (Med Express) * Poliovirus wastewater surveillance in NY (Dept of Health) * Wastewater surveillance in NYS (Dept of Health) * Estimating norovirus infections through wastewater (Water Res) * Estimating antimicrobial resistant bacteria through latrine water (Antimicro Res Inf Control)
Intro music is by Ronald Jenkees
Send your questions and comments to twiv@microbe.tv
Laurie Garrett discusses the role of wastewater testing in public health and her idea of a device that could be used by anyone to analyze water samples.
This podcast is not an episode of TWiV, but I thought it would be of interest to listeners.
Laurie Garrett and Vincent Racaniello
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Coliform testing of water in Florida (YouTube) * Declining cost of genome sequencing (Illumina) * National wastewater surveillance system (CDC) * Advances in detection of viruses in wastewater (Med Express) * Wastewater monitoring comes of age (Nature) * Monitoring monkeypox virus in wastewater (Med Express) * Poliovirus wastewater surveillance in NY (Dept of Health) * Wastewater surveillance in NYS (Dept of Health) * Estimating norovirus infections through wastewater (Water Res) * Estimating antimicrobial resistant bacteria through latrine water (Antimicro Res Inf Control)
Intro music is by Ronald Jenkees
Send your questions and comments to twiv@microbe.tv
Paul Offit returns to TWiV for a discussion of SARS-CoV-2 bivalent boosters containing ancestral and Omicron spike mRNAs, including their composition, why they are being recommended by CDC, and who would benefit the most from them.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Paul Offit
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * CDC oversells bivalent booster (Wall St Journal) * FDA authorizes bivalent COVID-19 booster * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz favorites: Small group #4: Gerry Mulligan Quartet with Chet Baker: Gerry Mulligan, Baritone saxophone; Carson Smith, Bass; Larry Bunker, Drums, Chet Baker, Trumpet. Signature album: The Best Of The Gerry Mulligan Quartet With Chet Baker: Signature song: My Funny Valentine.
Second pick: Wonder: Childhood and the Lifelong love of Science. Frank C. Keil.
Brianne – A Devious Cellular Trick Cancers Can Use to Escape Your Immune System
Kathy – Durable antimicrobial coating
Rich – One Health
Vincent – The works of Dashiell Hammett
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID.
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Become a patron of TWiV!
Links for this episode * Research assistant position with Amy Rosenfeld (pdf) * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Increase in Acute Respiratory illnesses among children and adolescents (CDC) * Estimates of Monkeypox incubation period, generation time, reproduction number (CDC) * Rapid increase in suspected SARS-CoV-2 reinfections (CDC) * Infection prevention and control recommendations for healthcare providers (CDC) * SARS-CoV-2 attack rate in vaccinated and unvaccinated household contacts (CDC) * Breakthrough Infection by variants elicited immune response comparable to vaccine (JID) * Interval between prior SARS-CoV-2 infection and booster vaccination impacts (CELL) * Humoral immunity evasion of BA.4 and BA.5 subvariants (The Lancet) * Outpatient Remdesivir prevents severe disease in organ transplant recipients (Am J Transplant) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Effectiveness of Molnupiravir in high risk patients (CID) * Update on Long COVID for primary care (BMJ) * Distinct symptom pattern emerges for COVID-19 long-haul (Scientific Reports) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 941 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses increased acute respiratory illnesses among children and adolescents, estimates of monkeypox incubation period, generation time, and reproduction number, rapid increase in suspected SARS-CoV-2 reinfections, interim infection prevention and control recommendations for healthcare personnel during COVID-19, SARS-CoV-2 secondary attack rates in vaccinated and unvaccinated household contacts during replacement of delta with omicron variant, breakthrough infection by SARS-CoV-2 delta and omicron variants elicited immune response comparable to mRNA booster vaccination, interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses, further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants, short-course early outpatient Remdesivir prevents severe disease due to COVID-19 in organ transplant recipients during the Omicron BA.2 wave, effectiveness of Molnupiravir in high risk patients, and primary care and a distinct symptom pattern for long COVID.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position with Amy Rosenfeld (pdf) * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Increase in Acute Respiratory illnesses among children and adolescents (CDC) * Estimates of Monkeypox incubation period, generation time, reproduction number (CDC) * Rapid increase in suspected SARS-CoV-2 reinfections (CDC) * Infection prevention and control recommendations for healthcare providers (CDC) * SARS-CoV-2 attack rate in vaccinated and unvaccinated household contacts (CDC) * Breakthrough Infection by variants elicited immune response comparable to vaccine (JID) * Interval between prior SARS-CoV-2 infection and booster vaccination impacts (CELL) * Humoral immunity evasion of BA.4 and BA.5 subvariants (The Lancet) * Outpatient Remdesivir prevents severe disease in organ transplant recipients (Am J Transplant) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Effectiveness of Molnupiravir in high risk patients (CID) * Update on Long COVID for primary care (BMJ) * Distinct symptom pattern emerges for COVID-19 long-haul (Scientific Reports) * Dr. Griffin’s treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 941 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab.
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Eddie Holmes
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Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Novel 2019 coronavirus genome (Virological) * Proximal origins of SARS-CoV-2 (Virological and Nature versions) * Original paper on new CoV in China that led to genome sequence release (Nature) * Reporting on Fauci teleconference (USA Today) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Eddie Holmes joins TWiV to discuss his role in the first release of the SARS-CoV-2 genome sequence, what really happened during the infamous Fauci teleconference, and evidence that the virus came from Nature and not from a lab.
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Eddie Holmes
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Novel 2019 coronavirus genome (Virological) * Proximal origins of SARS-CoV-2 (Virological and Nature versions) * Original paper on new CoV in China that led to genome sequence release (Nature) * Reporting on Fauci teleconference (USA Today) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Tom Monath
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Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Fever by John Fuller (Amazon) * Crozet BioPharma * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz – Small Group #3: Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five.
Rich – Wilderness Safaris (wiki)
Alan – Madhouse at the End of the Earth, by Julian Sancton
Vincent – Raymond Chandler and his protagonist Philip Marlowe.
Listener Picks Philip – Students bitten by bats inside college residence hall
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Tom Monath
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Support MicrobeTV with a Spike t-shirt (Vaccinated.us) * Fever by John Fuller (Amazon) * Crozet BioPharma * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz – Small Group #3: Dave Brubeck Quartet. Dave Brubeck, Piano; Joe Morello, Drums, Paul Desmond, Alto Saxophone, Eugene Wright, Bass: Signature Album: Time Out. Signature Song: Take Five.
Rich – Wilderness Safaris (wiki)
Alan – Madhouse at the End of the Earth, by Julian Sancton
Vincent – Raymond Chandler and his protagonist Philip Marlowe.
Listener Picks Philip – Students bitten by bats inside college residence hall
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Research assistant position with Amy Rosenfeld (pdf) * Public health response to polio in New York (MMWR) * Impact of mandatory influenza vaccination (Cambridge Core) * Monkeypox in young infant (MMWR) * Health care worker exposure to monkeypox virus (MMWR) * Monkeypox testing delays (Cambridge Core) * Monkeypox in smallpox vaccinated patient (Emerg Inf Dis) * Transmission potential of monkeypox virus (Int J Epidemiol) * TPOXX trial for monkeypox (ACTG) * SARS-CoV-2 subgenomic mRNA detection (J Inf Dis) * Quantitative SARS-CoV-2 subgenomic mRNA for Remdesivir treatment (Clin Inf Dis) * Anti-spike mucosal IgA (NEJM) * BNT262bs against Omicron sublineages (NEJM) * Awareness and use of SARS-CoV-2 antivirals (Clin Inf Dis) * Comparable outcomes for Bebtelovimab and Nirmatrelvir treatment (J Inf Dis) * COVID-19 and Alzheimer's disease (J Alzheimer's Dis) * Dr. Griffin's treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 938 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin reviews the public health response to poliovirus in New York, impact of mandatory influenza vaccination, monkeypox in a young infant, health care worker exposure to monkeypox virus, monkeypox testing delays, transmission potential of monkeypox virus, TPOXX trial for monkeypox, detection of SARS-CoV-2 subgenomic mRNA, mucosal IgA against SARS-CoV-2, BNT262b2 against Omicron, awareness and use of SARS-CoV-2 antivirals, comparable outcomes for Bebtelovimab and Nirmatrelvir, and COVID-19 and Alzheimer's disease.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Support MicrobeTV with a Spike t-shirt at Vaccinated.US * Research assistant position with Amy Rosenfeld (pdf) * Public health response to polio in New York (MMWR) * Impact of mandatory influenza vaccination (Cambridge Core) * Monkeypox in young infant (MMWR) * Health care worker exposure to monkeypox virus (MMWR) * Monkeypox testing delays (Cambridge Core) * Monkeypox in smallpox vaccinated patient (Emerg Inf Dis) * Transmission potential of monkeypox virus (Int J Epidemiol) * TPOXX trial for monkeypox (ACTG) * SARS-CoV-2 subgenomic mRNA detection (J Inf Dis) * Quantitative SARS-CoV-2 subgenomic mRNA for Remdesivir treatment (Clin Inf Dis) * Anti-spike mucosal IgA (NEJM) * BNT262bs against Omicron sublineages (NEJM) * Awareness and use of SARS-CoV-2 antivirals (Clin Inf Dis) * Comparable outcomes for Bebtelovimab and Nirmatrelvir treatment (J Inf Dis) * COVID-19 and Alzheimer's disease (J Alzheimer's Dis) * Dr. Griffin's treatment guide (pdf) * Contribute to Floating Doctors fundraiser at PWB * Letters read on TWiV 938 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2.
Hosts: Vincent Racaniello
Guest: Emma Thomson
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Links for this episode * Thomson laboratory * Emma on TWiV 188 and TWiV 341 * AAV2-associated pediatric hepatitis (bioRxiv) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2.
Hosts: Vincent Racaniello
Guest: Emma Thomson
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Thomson laboratory * Emma on TWiV 188 and TWiV 341 * AAV2-associated pediatric hepatitis (bioRxiv) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 and is not induced by subsequent vaccination, resistance of SARS-CoV-2 Omicron subvariant BA.4.6 to antibody neutralization, persistent circulating SARS-CoV-2 spike associated with post-acute COVID-19 sequelae, and impact of COVID-19 vaccination on the risk of developing long-covid and on existing long-covid symptoms.
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Links for this episode * Detection of poliovirus in immunosuppressed child (CDC) * Severe respiratory illnesses associated with rhinoviruses and/or enteroviruses (CDC) * Effects of vaccination and previous Omicron infection in children (NEJM) * COVID-19 hospitalizations among vaccinated and unvaccinated adults (JAMA) * Effectiveness of vaccines prior to Omicron (IDSA) * Nasal iga wanes 9 months after COVID hospitalization (medRxiv) * Resistance of Omicron subvariant to antibody neutralization (BioRxiv) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * SARS-CoV-2 spike is associated with post-acute sequelae (IDSA) * Impact of vaccination on the risk of developing long-COVID (The Lancet) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin's treatment guide (pdf) * Letters read on TWiV 936 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to Cornell University to speak with Cedric about his career and his research on mobile genetic elements such as transposons and endogenous viruses and how they have shaped the evolution of nearly all organisms.
Hosts: Vincent Racaniello
Guest: Cedric Feschotte
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Links for this episode * Feschotte laboratory * Field guide to transposable elements (Ann Rev Genetics) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses variant influenza virus infections: recommendations for identification, treatment, and prevention for summer and fall 2022, low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals, using the right tools at the right time for SARS-COV-2 infection, onset and window of SARS-COV-2 infectiousness and temporal correlation with symptom onset, transmission of SARS-COV-2: a review of viral, host, and environmental factors, antibody persistence and safety through 6 months after heterologous orally aerosolized Ad5-nCoV in individuals primed with two-dose vaccine, timely administration of tocilizumab improves outcome of hospitalized COVID-19 patients, administration of anti–SARS-COV-2 monoclonal antibodies after US Food and Drug Administration deauthorization, and clinical and genetic risk factors for acute incident venous thromboembolism in ambulatory patients with COVID-19.
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Links for this episode * 2022 recommendations for Influenza infections (CDC) * Low levels of monkeypox neutralizing antibodies after vaccination (medRxiv) * Using the right tools during SARS-CoV-2 infection (ESMED) * Onset and window of SARS-CoV-2 infectiousness with symptom onset (The LANCET) * Transmission of SARS-COV-2 (ACP Journals) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Administration of anti–SARS-COV-2 monoclonal antibodies (JAMA) * Clinical and genetic risk factors for thromboembolism (JAMA) * Administration of tocilizumab improves outcomes (PLOS One) * Antibody persistence and safety through 6 months (medRxiv) * Improve risk score for thromboembolism (mdCalc) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 934 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Beijerinck virology prize (KNAW) * Nipah virus vaccine (TWiV 618) * Novel henipavirus from Madagascar (J Viral) * Spike-independent Omicron attenuation in mice (Cell Rep) * Letters read on TWiV 933 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Small groups: 3. Modern Jazz Quartet. Signature song: Skating in Central Park. Signature album: Django.
Brianne – To Prevent a Martian Plague, NASA Needs to Build a Very Special Lab
Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth
Vincent – Lab leaders wrestle with paucity of postdocs
Listener Picks Gary – Stan Kenton Orchestra
Miguel – Microsoft Premonition
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Research assistant position at FDA (pdf) * Beijerinck virology prize (KNAW) * Nipah virus vaccine (TWiV 618) * Novel henipavirus from Madagascar (J Viral) * Spike-independent Omicron attenuation in mice (Cell Rep) * Letters read on TWiV 933 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Small groups: 3. Modern Jazz Quartet. Signature song: Skating in Central Park. Signature album: Django.
Brianne – To Prevent a Martian Plague, NASA Needs to Build a Very Special Lab
Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth
Vincent – Lab leaders wrestle with paucity of postdocs
Listener Picks Gary – Stan Kenton Orchestra
Miguel – Microsoft Premonition
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Vaccine effectiveness against Influenza illness in children (CID) * Clinical manifestations of infection with Polio (JAMA) * Characteristics of deaths among fully vaccinated persons with Coronavirus (CID) * Spike protein attenuation of Omicron Variant in lab mice (Cell Reports) * Concordance of SARS-CoV-2 results in nasal swabs self-collected vs healthcare collected (JAMA) * Probable animal-to-human transmission of Sars-Cov-2 (CID) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * COVID-19–associated hospitalizations among adults during BA.2 variant (CDC) * Sars-Cov-2 specific T-cells and antibodies (CID) * Nirmatrelvir use and outcomes during the Omicron surge (NEJM) * Effectiveness of early Molnupiravir or Nirmatrelvir–Ritonavir in hospitalized patients (The Lancet) * Distinguishing features of long COVID (medRxiv) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 932 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatrelvir use and outcomes during the Omicron surge, real-world effectiveness of early Molnupiravir or Nirmatrelvir–ritonavir in hospitalized patients, and distinguishing features of long COVID.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Vaccine effectiveness against Influenza illness in children (CID) * Clinical manifestations of infection with Polio (JAMA) * Characteristics of deaths among fully vaccinated persons with Coronavirus (CID) * Spike protein attenuation of Omicron Variant in lab mice (Cell Reports) * Concordance of SARS-CoV-2 results in nasal swabs self-collected vs healthcare collected (JAMA) * Probable animal-to-human transmission of Sars-Cov-2 (CID) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * COVID-19–associated hospitalizations among adults during BA.2 variant (CDC) * Sars-Cov-2 specific T-cells and antibodies (CID) * Nirmatrelvir use and outcomes during the Omicron surge (NEJM) * Effectiveness of early Molnupiravir or Nirmatrelvir–Ritonavir in hospitalized patients (The Lancet) * Distinguishing features of long COVID (medRxiv) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 932 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Characterization of novel OPV2 from humans (MMWR) * Engineering nOPV2 (TWiV 756) * Genome sequence of Rockland County NY OPV2 isolate (Genbank) * Allelic polymorphism and vaccine induction of influenza virus bnAbs (Immunity) * Letters read on TWiV 931 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Small groups: 1. Miles Davis Quintet: Miles Davis, trumpet, John Coltrane, Tenor saxophone; Cannonball Adderley, Alto saxophone; Winton Kelly, Bill Evans, Piano; Paul Chambers, Bass; Jimmy Cobb, Drums. Signature album: Kind Of Blue. Signature song: So What. Many jazz enthusiasts think this is the best jazz album ever recorded. performed on separate tracks
Brianne – World Excel Championships
Kathy – yre bird background and video
Alan – The Kissing Bug, by Daisy Hernandez
Vincent* -Five top detective fiction writers. #1 Martin Beck by Maj Sjöwall and Per Wahlöö
Listener Picks John – Fevers, Feuds and Diamonds: Ebola and the Ravages of History by Paul Farmer
Carol – The Social Dilemma
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV reviews the genetic characterization of a new strain of type 2 oral polio vaccine and its implications for eradication, and how a polymorphism in humans comprising a single amino acid change in an antibody molecule regulates vaccine elicitation of broadly neutralizing antibodies against influenza virus HA.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode * Characterization of novel OPV2 from humans (MMWR) * Engineering nOPV2 (TWiV 756) * Genome sequence of Rockland County NY OPV2 isolate (Genbank) * Allelic polymorphism and vaccine induction of influenza virus bnAbs (Immunity) * Letters read on TWiV 931 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Small groups: 1. Miles Davis Quintet: Miles Davis, trumpet, John Coltrane, Tenor saxophone; Cannonball Adderley, Alto saxophone; Winton Kelly, Bill Evans, Piano; Paul Chambers, Bass; Jimmy Cobb, Drums. Signature album: Kind Of Blue. Signature song: So What. Many jazz enthusiasts think this is the best jazz album ever recorded. performed on separate tracks
Brianne – World Excel Championships
Kathy – yre bird background and video
Alan – The Kissing Bug, by Daisy Hernandez
Vincent* -Five top detective fiction writers. #1 Martin Beck by Maj Sjöwall and Per Wahlöö
Listener Picks John – Fevers, Feuds and Diamonds: Ebola and the Ravages of History by Paul Farmer
Carol – The Social Dilemma
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer, Pfizer and BioNTech submit application for bivalent vaccine, and Oral Nirmatrelvir and Ritonavir in non-hospitalized vaccinated patients with COVID-19.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
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Links for this episode * Antibody response against nonpoliovirus enteroviruses (ASM) * Clinical presentation of Monkeypox cases in Spain (The Lancet) * Object and surface contamination with Monkeypox virus infection (CDC) * Environmental persistence of Monkeypox virus (Emerg Inf Dis) * Monkeypox virus infection across 16 countries (NEJM) * Clinical characteristics of hospitalization patients with Monkeypox (CMI) * Usage of Tecovirimat for treatment of Monkeypox infection (JAMA) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Monitoring of Pfizer-BioNTech vaccine among children (CDC) * Pfizer and BioNTech announce updated vaccine data (Pfizer) * Capture of RBD enables point of care assessment (Science Direct) * Pfizer and BioNTech submit application for bivalent vaccine (Pfizer) * PAXLOVID in non-hospitalized vaccinated patients * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 930 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer, Pfizer and BioNTech submit application for bivalent vaccine, and Oral Nirmatrelvir and Ritonavir in non-hospitalized vaccinated patients with COVID-19.
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Links for this episode * Antibody response against nonpoliovirus enteroviruses (ASM) * Clinical presentation of Monkeypox cases in Spain (The Lancet) * Object and surface contamination with Monkeypox virus infection (CDC) * Environmental persistence of Monkeypox virus (Emerg Inf Dis) * Monkeypox virus infection across 16 countries (NEJM) * Clinical characteristics of hospitalization patients with Monkeypox (CMI) * Usage of Tecovirimat for treatment of Monkeypox infection (JAMA) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Monitoring of Pfizer-BioNTech vaccine among children (CDC) * Pfizer and BioNTech announce updated vaccine data (Pfizer) * Capture of RBD enables point of care assessment (Science Direct) * Pfizer and BioNTech submit application for bivalent vaccine (Pfizer) * PAXLOVID in non-hospitalized vaccinated patients * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 930 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
Guest: Andy Slavitt
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Links for this episode * In the Bubble podcast * Preventable (Amazon) * Letters read on TWiV 929 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Best big band #5: 1. Glenn Miller’s Orchestra -1940-1944: Signature song: In The Mood. Signature album: An Album Of Outstanding Arrangements
Brianne – Cross-stitched Microbes
Kathy – Time trials for bottle emptying
Alan – Meow Parlor
Vincent – VIRUS x1,000,000 (2022) by Drew Berry wehi.tv
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Andy Slavitt joins TWiV to discuss his book, Preventable and how failures in leadership, politics, and selfishness doomed the U.S. response to SARS-CoV-2.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
Guest: Andy Slavitt
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Become a patron of TWiV!
Links for this episode * In the Bubble podcast * Preventable (Amazon) * Letters read on TWiV 929 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Best big band #5: 1. Glenn Miller’s Orchestra -1940-1944: Signature song: In The Mood. Signature album: An Album Of Outstanding Arrangements
Brianne – Cross-stitched Microbes
Kathy – Time trials for bottle emptying
Alan – Meow Parlor
Vincent – VIRUS x1,000,000 (2022) by Drew Berry wehi.tv
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses the public health response to a polio case in a unvaccinated NY state resident, human to dog transmission of monkeypox virus, Tecovirimat and the treatment of monkeypox, detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium, what to do if you are exposed to SARS-CoV-2 and isolation and precautions for people with COVID-19, risk of SARS-CoV-2 infection in health care workers, effectiveness of HEPA filters at removing infectious SARS-CoV-2 from the air, Pfizer reports additional data on Paxlovid, hospitalization encounters for infection after Paxlovid, a randomized trial of Metformin, Ivermectin, and Fluvoxamine, and readmissions, post-discharge mortality and sustained recovery among patients admitted to hospital with COVID-19.
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Links for this episode * Response to Polio case in an unvaccinated person in New York (CDC) * Human to dog transmission of Monkeypox virus (The Lancet) * Tecovirimat for the treatment of Monkeypox (NEJM) * Detection of asymptomatic Monkeypox among Belgian men (Nature Medicine) * Exposure to disease and precautions (CDC) * Risk of infection in healthcare workers (JAMA) * Effectiveness of HEPA filters (ASM) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Pfizer reports additional data on PAXLOVID (Pfizer) * Hospitalization encounters for infection after PAXLOVID (CDC) * Trial for Metformin, Ivermectin, and Fluvoxamine (NEJM) * Readmission, post-discharge mortality, recovery among patients (IDSA) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 928 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Michael Merchlinsky
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Links for this episode * Michael on Anything but academic (TWiM 145) * Development of Tecoviromat (TPOXX) (Antiviral Res) * Use of Jynneos vaccine (MMWR) * Limitations of Tecoviromat (NEJM) * Poliovirus in NYC wastewater (NY Times) * Letters read on TWiV 927 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958
Kathy – How the US Postal Service reads terrible handwriting
Rich – JWST/chorizo gag
Vincent – Bat Conservation Trust
Listener Picks Bill – The End of Manual Transmission
J – How the Krebs cycle powers life and death – with Nick Lane
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Michael Merchlinsky
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Links for this episode * Michael on Anything but academic (TWiM 145) * Development of Tecoviromat (TPOXX) (Antiviral Res) * Use of Jynneos vaccine (MMWR) * Limitations of Tecoviromat (NEJM) * Poliovirus in NYC wastewater (NY Times) * Letters read on TWiV 927 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958
Kathy – How the US Postal Service reads terrible handwriting
Rich – JWST/chorizo gag
Vincent – Bat Conservation Trust
Listener Picks Bill – The End of Manual Transmission
J – How the Krebs cycle powers life and death – with Nick Lane
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection.
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Links for this episode * Guidance for prevention & treatment of Monkeypox (CDC) * Post-infection symptoms among children and adolescents (CDC) * Profiling post-infection syndromes in different variants (medRxiv) * Comparison of vaccinia Ankara (MVA) vs intradermal routes of administration (NIH) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Infection in vaccinated individuals treated with or without PAXLOVID (medRxiv) * Duration of symptoms with positive rapid antigen after infection (J Virological Methods) * Epidemiologic characteristics of Monkeypox (CDC) * Sequelae of post-acute infection (ScienceDirect) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 926 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In his weekly clinical update Dr. Griffin discusses guidance for prevention and treatment of monkeypox, post-infectious symptoms among children and adolescents, profiling post-infectious syndromes of different variants, comparison of vaccine Ankara vs intradermal routes of administration, infection in vaccinated individuals treated with or without PAXLOVID, duration of symptoms with positive rapid antigen after infection, epidemiologic characteristics of monkeypox, and sequelae of post-acute infection.
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Links for this episode * Guidance for prevention & treatment of Monkeypox (CDC) * Post-infection symptoms among children and adolescents (CDC) * Profiling post-infection syndromes in different variants (medRxiv) * Comparison of vaccinia Ankara (MVA) vs intradermal routes of administration (NIH) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Infection in vaccinated individuals treated with or without PAXLOVID (medRxiv) * Duration of symptoms with positive rapid antigen after infection (J Virological Methods) * Epidemiologic characteristics of Monkeypox (CDC) * Sequelae of post-acute infection (ScienceDirect) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 926 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses monkeypox virus, poliovirus in NY, Marburg virus in Ghana, ancient herpes simplex virus type 1 genomes, and immunogenicity of different combinations of SARS-CoV-2 vaccines.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * How monkeypox virus spreads (CDC) * Vaccination against monkeypox virus (CDC) * Monkeypox case trends (CDC) * Polio in New York State (NY Dept of Health) * Poliovirus in NY wastewater (NBC New York) * Marburg disease in Ghana (WHO) * Ancient herpesvirus genomes (Sci Adv) * Combinations of SARS-CoV-2 vaccines (Cell Rep Medicine) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Everyone Loses on Jeopardy Eventually
Kathy – Climate spiral followed by Carl Sagan
Rich – Most Popular Desktop Browsers 1993 – 2022
Alan – I Am Promise
Vincent – Polio in New York
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses Tecovirimat for treatment of monkeypox, the safety and acceptance of vaccination after multisystem inflammatory syndrome, variants in solid organ transplant recipients, masks for prevention of respiratory virus infections, pre-exposure prophylaxis with Evusheld, the association between Evusheld administration and infection, if repeat administration of casirivimab and imdevimab is well-tolerated, viral and symptom rebound in untreated infection, extended Remdesivir infusion for persistent infection, Baricitinib in patients admitted with infection, and cognitive impairment 13 months after hospitalization.
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Links for this episode * Armchair Expert with Malcolm Gladwell * Tecovirimat for treatment of monkeypox (OFID) * Safety and acceptance of vaccination after MIS (JPID) * Is variant less virulent in solid organ transplant recipients (Transplant Infectious Disease) * Masks for prevention of respiratory virus infections (Annals of Internal Medicine) * Pre-exposure prophylaxis with Evusheld (CMI) * Association between Evusheld administration and infection (CID) * Repeat administration of casirivimab and imdevimab well-tolerated (ISID) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Viral and symptom rebound in untreated infection (medRxiv) * Extended Remdesivir infusion for persistent infection (OFID) * Baricitinib in patients admitted with infection (The Lancet) * Cognitive Impairment 13 months after hospitalization (OFID) * Contribute to Floating Doctors fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 924 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events.
Hosts: Vincent Racaniello and Brianne Barker
Guests: Vincent Munster and Raina Plowright
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Links for this episode * Novel Hendra virus variant in Australia (Emerg Inf Dis) * Nipah virus detection after spillover events (Emerg Inf Dis) * Want to prevent pandemics? Stop spillovers (Nature) * Ecological countermeasures to prevent zoonoses (Restor Ecol) * Land-use induced spillovers (Lancet Planet Health) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From The Third International Symposium on Infectious Diseases of Bats in Ft. Collins, Colorado, TWiV speaks with Vincent Munster and Raina Plowright about their careers and their research on bats, bat viruses, bat ecology and spillover events.
Hosts: Vincent Racaniello and Brianne Barker
Guests: Vincent Munster and Raina Plowright
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Links for this episode * Novel Hendra virus variant in Australia (Emerg Inf Dis) * Nipah virus detection after spillover events (Emerg Inf Dis) * Want to prevent pandemics? Stop spillovers (Nature) * Ecological countermeasures to prevent zoonoses (Restor Ecol) * Land-use induced spillovers (Lancet Planet Health) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In his weekly clinical update Dr. Griffin discusses monkeypox infection in humans across 16 countries, pregnancy outcomes after SARS-CoV-2 infection by trimester, vaccination intent and belief, antiviral drug treatment for non-severe disease, the association of smoking with infected hospitalized patients, the association of Paxlovid on negative conversion rates among high-risk patients with COVID-19, safety and efficacy of Molnupiravir, usage of enoxaparin for primary thromboprophylaxis, statin and aspirin as therapy in infected patients, post-COVID-19 conditions among children 90 days after SARS-CoV-2 Infection, and symptoms and risk factors for long COVID in non-hospitalized adults.
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Links for this episode * Monkeypox infection in humans (NEJM) * Pregnancy outcomes after infection (PLOS ONE) * Vaccination intent and belief (Emerging Infectious Diseases) * Antiviral drug treatment for non-severe disease (CMAJ) * Smoking association with infected hospitalized patients (PLOS ONE) * Impact of Paxlovid on negative conversion rates (CID) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Safety and efficacy of Molnupiravir (Journal of Medical Virology) * Enoxaparin for primary thromboprophylaxis (OVID) * Statin and aspirin as therapy in infected patients (BMC) * Post-infection conditions among children (JAMA) * Symptoms and risk factors for long-term effects (Nature Medicine) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 922 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Pamela Bjorkman and Andy Mehle
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Links for this episode * Bjorkman laboratory * Mehle laboratory * Finding the groove (Nat Immunol) * Structure of HLA-A2 (Nat Immunol) * Mosaic RBD nanoparticles (Science) * Influenza virus PB2 627 (J Virol) * ANP32B or not to be (eLife) * Influenza virus compartmentalization (Nat Commun) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Pamela Bjorkman and Andy Mehle
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Links for this episode * Bjorkman laboratory * Mehle laboratory * Finding the groove (Nat Immunol) * Structure of HLA-A2 (Nat Immunol) * Mosaic RBD nanoparticles (Science) * Influenza virus PB2 627 (J Virol) * ANP32B or not to be (eLife) * Influenza virus compartmentalization (Nat Commun) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.
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Links for this episode * Variant vaccine boosters trial (medRxiv) * Novavax triggers neutralization of variant sub-lineages (bioRxiv) * CDC recommends Novavax (CDC) * Paxlovid in patients who are immunocompromised and hospitalized (The Lancet) * Inhaled Fluticasone for outpatient treatment (medRxiv) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 921 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In COVID-19 clinical update #124, Dr. Griffin discusses the results of a variant vaccine booster trial, the neutralization of variant sub-lineages by Novavax, the CDC’s recommendation of Novavax’s COVID-19 vaccine in adults, Paxlovid in patients who are immunocompromised and hospitalized, and inhaled fluticasone for outpatient treatment.
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Become a patron of TWiV!
Links for this episode * Variant vaccine boosters trial (medRxiv) * Novavax triggers neutralization of variant sub-lineages (bioRxiv) * CDC recommends Novavax (CDC) * Paxlovid in patients who are immunocompromised and hospitalized (The Lancet) * Inhaled Fluticasone for outpatient treatment (medRxiv) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 921 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * COVID-19 vaccine booster composition (FDA) * Settling in for the long haul (Crooked Timber) * Flavivirus-induced skin volatile attracts mosquitoes (Cell) * Letters read on TWiV 919 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Redactle
Kathy – Kirigami paper replacing plastic bubble wrap
Rich – First Images from the James Webb Space Telescope (Gravitational lens; Einstein ring)
Vincent – Spotted lanternfly
Listener Picks Ann – NASA Engineer Who Made the James Webb Space Telescope Work
Sonrisa – Aloft – the pleasures and risks of flying
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of multisystem inflammatory syndrome in children, and neurovascular injury with complement activation and inflammation during infection.
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Links for this episode * Monkeypox outbreak rapid testing response (CDC) * Leading causes of death during pandemic (JAMA) * FDA recommends vaccine update (FDA) * Antibody evasion by subvariants (Nature) * Broadly-Neutralizing antibodies against variants (Frontiers in Immunology) * Severe outcomes factors in immunocompromised adults (CDC) * Measurement of the burden of hospitalizations (OFID) * Vaccine hesitancy among parents (Academic Pediatrics) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Saliva evaluation to improve diagnostics (ASTMH) * Oral Sabizabulin for high-risk adults (NEJM) * Lower risk of MIS-C in children (CID) * Neurovascular injury during infection (Brain) * Paul Offit on TWiV 917 * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 918 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Paul Offit
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Links for this episode * 28 June 2022 VRBPAC meeting materials (FDA) * Don’t rush to change COVID vaccines (STAT) * Materials from 28 June FDA advisory meeting (FDA) * Letters read on TWiV 917 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Woody Herman and his orchestra. 1955-1965. Signature song: The Preacher. Signature album: Woody Herman and His Orchestra (1956)
Kathy – Solargraphic analemmas
Rich – Windy (desktop; app)
Vincent – Why monkeypox is mostly hitting men who have sex with men
Listener Picks Mark – Hand Wash Dance – NHK WORLD-JAPAN
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding of virus, how thromboprophylaxis reduces thromboembolism but increases major bleeding, multi-lineage neural and myelin dysregulation caused by infection, and the association between vaccination and post-acute infection.
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Links for this episode * Vaccine availability and coverage among children (CDC) * Post-infection health impairments in children & adolescents (Pediatrics) * Infection detection using saliva & nasopharyngeal samples (Journal of Medical Virology) * Effectiveness of vaccines during Delta dominance (The Lancet) * Durability of vaccine against severe outcomes (The Lancet) * Concern in the postvaccination era (Immunity, Inflammation and Disease) * Infection rebound after Paxlovid & Molnupiravir (medRxiv) * No improvement after Ivermectin usage (ACP) * Duration of shedding of virus (New England Journal of Medicine) * Thromboprophylaxis reduces thromboembolism (NIH) * Multi-lineage neural cell and myelin dysregulation caused by infection (Cell) * Association between vaccination and post-acute infection (JAMA) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 916 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker.
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Links for this episode * Postdoctoral position in the Kielian Laboratory (pdf) * COVID vaccine update for fall (WaPo) * Don’t rush to change COVID vaccines (STAT) * Materials from 28 June FDA advisory meeting (FDA) * Monkeypox cases US and Global (CDC) * Enteric viruses transmit via saliva (Nature) * Letters read on TWiV 915 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Jazz big bands #2: Maynard Ferguson: Signature song: Theme From Rocky: Signature album: Color Him Wild
Brianne – Origami antibody and virus
Kathy – Turbines resistant to high winds
Rich – Obi-Wan Kenobi (TV Series)
Vincent – The next epidemic may be here. The US isn’t ready for it.
Listener Picks David: DALL E 2
Douglas – Jazz Online
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity.
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Links for this episode * Age as a risk factor for severe disease (NY Times) * Omicron boosters for the fall (NPR) * Pediatric infection and antibody seroprevalence in Arkansas (PIDS) * All-cause US maternal mortality during pandemic (JAMA) * Effect of 2-week interruption in methotrexate treatment (The Lancet) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * PAXLOVID drug interaction checker (IDSA) * Contribute to FIMRC fundraiser at PWB 35:42 * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 914 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler.
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Links for this episode * Poliovirus in UK sewage (ProMedMail and Science) * Poliovirus eradication effort (Science) * Long COVID after Delta and Omicron (Lancet) * How common is long COVID? (Nature) * Immune enhancers as antivirals (Cell Chem Biol) * Letters read on TWiV 913 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Count Basie: April in Paris
Kathy – Bird aerodynamics & inertia: lay article, video, Nature
Rich – NASA Gateway (Thanks Ellis)
Alan – Polio Eradication in Nigeria
Vincent – The Tyranny of Merit by Michael J. Sandel
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants.
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Links for this episode * Reinfection outcomes (Research Square) * CDC recommends vaccine for young children (CDC) * Neurodevelopment outcomes in infants post-infection (JAMA) * Efficacy of monoclonal antibodies/antivirals in hamsters (Nature) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * PAXLOVID drug interaction checker * Rebound phenomenon after PAXLOVID in high-risk persons (IDSA) * Hospitalization for infection after PAXLOVID treatment (CDC) * Risk of post acute infection with different variants (the Lancet) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 912 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Hepatitis of unknown etiology (MMWR) * Clinical recognition of monkeypox (CDC) * Epstein-Barr virus nanoparticle vaccine (Cell Rep Med) * Minimal impact of mAb therapy on COVID vaccine induced antibodies (Sci Trans Med) * Letters read on TWiV 911 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – A Frog So Small, It Could Not Frog
Kathy – A Grand Night In: The Story of Aardman
Rich – Archive
Vincent – Bandwagoning by Heran Darwin
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection.
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Links for this episode * Tixagevimab-Cilgavimab for infection prevention (NEJM) * Ivermectin for outpatient infection treatment (medRxiv) * Symptom rebound after PAXLOVID treatment (IDSA) * Bamlanivimab minimally impacts immune response to vaccination (Sci Transl Med) * In-hospital morality among infected patients (IDSA) * Casirvimab/Imdevimab & Remdesivir for infected B-cell depleted patients (IDSA) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Residual viral antigen in patients post infection (IDSA) * Rheumatic symptoms following infection (IDSA) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 910 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration.
Hosts: Vincent Racaniello and Michael Schmidt
Guests: Michele Banks and Jane Hartman
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Links for this episode * Trilobite Glassworks (Jane Hartman) * Artologica (Michele Banks) * Science art with Michele Banks (TWiV 352) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episode * Monkeypox update (CDC) * SARS-CoV-2 infection of cats and dogs (Emerg Inf Dis) * Mouse papillomavirus identification (Vet Patrol) * Mouse model for papillomavirus infection (eLife) * Vincent interviews Harald zur Hausen (virology blog) * Letters read on TWiV 907 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Microbes Rule! at Liberty Science Center
Rich – Artemis I update: Mission diagram, mission in photos, launch dates
Vincent – Eco-sustainable 3D printed house – Tecla
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel’s booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in hospitalized patients, and factors associated with hospital readmission.
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Links for this episode * Management of hair loss after infection (NIH) * FDA announces vaccine schedule meeting (FDA) * FDA advisory committee recommends NOVAVAX vaccine (Novavax) * Moderna announces bivalent booster candidate (Moderna) * Association of vaccination and infection during pregnancy (JAMA) * Implications of Israeli booster campaign (Science Translational Medicine) * PAXLOVID patient eligibility screening checklist (FDA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * PAXLOVID outcomes during infection surge (Research Square) * Efficacy and safety of Tixagevimab–cilgavimab (The Lancet) * Diagnostic accuracy of infection by canines (PLOS ONE) * Efficacy of colchicine in hospitalized patients (Nature) * Factors associated with readmission (IDSA) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 908 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * Monkeypox update (ProMedMail) * Multi-country monkeypox outbreak (WHO) * Monkeypox new global threat (Science) * Monkeypox outbreak 9 US states (MMWR) * Mimivirus in human respiratory samples (Sci Rep) * Long COVID after post-vaccination infection (Nat Med) * Letters read on TWiV 906 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Lake Mead water level very low
Brianne – Transplantation of a 3D printed ear made out of human cells
Rich – nderstanding Vaccine Safety and the Roles of the FDA and the CDC and The Facts About Vaccine Safety
Vincent – My new favorite backpack
Listener Pick Greg – Against the Rules
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen test positivity duration, viral dynamics of variants and isolation, association of inflammation in CS fluid, and transmission dynamics in Ghana.
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Links for this episode * Duration of virus shedding (NIH) * Association between pre-exposure to steroids and infection outcome (CMI) * Post-infection subtypes (medRxiv) * Rehabilitation for post-acute infection syndrome (MDPI) * Tixagevimab/Cilgavimab for infection prevention (medRxiv) * Antibody prophylaxis & vaccination in kidney transplant recipients (Kidney International) * Guideline on treatment with Famotidine (IDSA) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * PAXLOVID rebound symptom characterization (medRxiv) * Antigen test positivity duration (medRxiv) * Viral dynamics of variants and isolation (NIH) * Association of inflammation in CS fluid (JAMA) * Transmission dynamics in Ghana (ASTMH) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 905 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research.
Hosts: Vincent Racaniello
Guests: David Baltimore, John Coffin, and Harold Varmus
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Links for this episode * Fifty Years of Reverse Transcriptase (Cold Spring Harbor Laboratory) * 50th Anniversary of RT discovery (Mol Biol Cell) * RT in virions of Rous sarcoma virus – Temin (Nature) * RNA-dependent DNA polymerase in tumor virus particles – Baltimore (Nature)
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and bebtelovimab fact sheets for providers, guidelines on usage of anticoagulation drugs, long covid symptoms after vaccination, excess mortality in MA, infection sequelae and immunity, and post infection conditions among adults.
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Links for this episode * Croup association with infection surge (PIDS) * Rhinovirus co-circulation in children (Science Direct) * Infection shedding following vaccination (MedRxiV) * High vaccine efficacy in children 6 months to 5 years (Pfizer) * Protection of vaccine against hospitalized patients (IDSA) * Convalescent plasma as post-exposure prophylaxis (IDSA) * Real-world effectiveness of PAXLOVID in Hong-Kong (MedRxiV) * Effectiveness of PAXLOVID in reducing hospitalization (The Lancet) * Infection rebound after PAXLOVID (CDC) * Relapse of symptomatic infection after PAXLOVID (Research Square) * Remdesivir fact sheet for providers (Veklury) * Bebtelovimab fact sheet for providers (FDA) * Guidelines on usage of anticoagulation drugs (ASH) * Long covid symptoms after vaccination (BMJ) * Excess morality in Massachusetts (JAMA) * Infection sequelae and immunity (Annals of Internal Medicine) * Post infection conditions among adults (CDC) * Contribute to FIMRC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 903 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk.
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Links for this episode * Monkeypox multi-country outbreak risk assessment (pdf, ECDC) * Monkeypox update (ProMedMail) * Monkeypox virus genome sequences (Nextstrain)
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Monkeypox in MA (ProMed Mail) * Possible monkeypox in NYC (NY Times) * Occupational monkeypox, Wisconsin (Emerg Inf Dis) * SARS-CoV-2 in feces (Nature) * IFN autoantibodies and severe COVID-19 (PNAS) * Letters read on TWiV 902 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – How to grow food on the moon
Brianne – APod May 16: Milky Way over French Alp Hoodoos
Kathy – Covid Nationwide data visualization
Rich – NIH All of Us Research Program
Vincent – Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine?
Listener Pick Lisa – E.H. Danner Museum of Telephony
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.
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Links for this episode * Limited cross-variant immunity without vaccination (Nature) * EUA for boosters in 5-11 year olds (FDA) * Stages of COVID-19 (AIDS Rev) * B.1.1.529 attack rate in Australia (JID) * Scent dogs (BMJ) * Does Omicron affect pets? (CVMBS News) * Paxlovid eligibility checklist (FDA) * Supratherapeutic tacrolimus with nirmatrelvir/ritonavir (Op For Inf Dis) * Is longer Paxlovid needed? (Reuters) * How about Veklury? (Gilead) * Fluvoxamine declined (FDA) * Antigen positivity after isolation (MMWR) * Inflammasome activation drives COVID-19 pathology (TWiV 900, Nature) * PASC and viral antigen persistence in gut (Gastroenterol) * GI symptoms and fecal shedding (Med) * Contribute to ASTMH fundraiser at PW * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 901 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Richard R. Ernst Lecture * Infected macrophages drives severe COVID-19 (Nature) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Milky Way’s Black Hole Comes to Light
Kathy – River dolphins playing with anaconda
Rich – Smallpox vaccination techniques; from knives and forks to needles and pins
Alan – Vacuum Tubes: a Modern Aladdin’s Lamp
Vincent – Books by Pamela Jane
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia.
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Links for this episode * Effects of early treatment with Ivermectin (NEJM) * Procalcitonin not a reliable biomarker (IDSA) * Evaluation of vaccine in children 6 to 11 years (NEJM)) * FDA limits use of Janssen vaccine (FDA) * Recall of b cell memory on vaccination location (Science Immunology) * Persistence screening using sniffer dogs (Journal of Clinical Trials) * Tixagevimab/Cilgavimab for treatment of hospitalized patients (Lancet) * Infection detection by canine olfaction (OFID) * Diagnostic utility to differentiate patients (IDSA) * Prevalence of anosmia in pediatric cases (Pediatric Infectious Disease Journal) * Risk assessment for public events (University of Texas COVID-19 Modeling Consortium) * PAXLOVID patient eligibility screening checklist (FDA) * PAXLOVID drug interactions (IDSA) * Contribute to ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 899 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Herd immunity may not apply to COVID-19 (J Inf Dis) * Smallpox vaccination increases skin bacteria (PLoS Path) * The invinceable TWiV (TWiV 145) * By the pricking of my thumbs… (TWiV 284) * Letters read on TWiV 898 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Bacteria and Me Coloring Book
Kathy – Smarter 3D printing
Rich – Big Ben Restoring the Worlds Most Famous Clock 2021
Vincent – Scientific review articles as antivaccine disinformation
Listener Pick Suellen – Your Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode)
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants.
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Links for this episode * Timing of Tocilizumab Use in Hospitalized Patients (NIH) * Interleukin-6 inhibitors reduce mortality (European Journal of Internal Medicine) * Treatment Effect of Baricitinib on Hospitalized Patients (IDSA) * Post Infection Neurological Sequelae (Res Square) * Comparative Effectiveness of Pfizer and Moderna Vaccines (Nature Commun) * Results from Phase 2/3 Study of Paxlovid (Pfizer) * Infection Relapse Following Suppression by Paxlovid (Res Square) * Update on Paxlovid Usage (FDA) * Availability and Use of Treatments in Outpatients (CDC) * Pre-Hospital Administration of Remdesivir (IDSA) * Remdesivir and three other drugs for Hospitalized Patients (Lancet) * Guidelines on Usage of Anticoagulants (Am Soc Hematol) * Different Variants Hospitalization and Morality (Res Square) * Contribute to FIMRIC fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 897 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.
Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld
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Links for this episode * Climate change and viral zoonosis risk (Nature) * COVID-19 mRNA boost effect on memory B cells (Nature) * Letters read on TWiV 896 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Toots Thilelemans
Amy – Largest comet ever identified
Vincent – Scientific review articles as antivaccine disinformation
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.
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Links for this episode * Seroprevalence of Infection-Induced Antibodies (CDC) * Authorization for Vaccine in Young Children Filed (Moderna) * Public Health Impact of Vaccines in US (BMJ) * FDA authorizes first approved treatment for children (FDA) * Phase 2 Data for Sabizabulin (Veru Pharma) * Clinical Characteristics of Post Infection Inflammation (The Lancet) * Fact Sheet for Providers on Evusheld (FDA) * Fact Sheet for Providers on Paxlovid (FDA) * Provider Referral for EvuSheld (Northwell Health) * Contribute to ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 895 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Severe hepatitis in children (WHO) * TMPRSS2 inhibitor (Nature) * Omicron less dependent on TMPRSS2 (TWiV 879) * Letters read on TWiV 894 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Apple AirTag
Kathy – Dental art/sculpture/mobile/chandelier
Alan – Vintage Radio and Communications Museum of Connecticut
Vincent – For the Love of Enzymes by Arthur Kornberg
Intro music is by Ronald Jenkees
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Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guests: Kartik Chandran, Denise Haslwanter, and Gorka Lasso Cabrera
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Links for this episode * Prometheus project (TWiV 578) * Reduced neutralization of South American yellow fever virus (Cell Host Microbe) * Letters read on TWiV 893 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Earth Day and Earth Day History
Brianne – XKCD: Family Reunion
Vincent – Tokaido: A Journey (DVD)
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID.
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Links for this episode * Vaccine coverage and mortality, Hong Kong (MMWR) * Kids behind on routine vaccinations (Politico) * Immune response to booster, 5-11 year olds (Pfizer) * Children and vaccination (AAP) * Hospitalization of 5-11 year olds (MMWR) * Test using breath samples (FDA) * Influenza virus, adenovirus, RS virus co-infections (Lancet) * Booster crystal ball (TWiV 890) * Bivalent vaccine (Res Square) * Bivalent vaccine in mice (bioRxiv) * Intramuscular Evusheld (NEJM) * Global PASC (J Inf Dis) * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 892 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi
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Links for this episode * Elke on TWiV 200 and Threading the NEIDL * Infectious Lloviu virus from bats in Hungary (Nat Commun) * Infectious Lloviu virus from DNA (PloS Path) * Letters read on TWiV 891 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – APod Stars and Globules in the Running Chicken Nebula
Kathy – BioRender Poster Builder
Rich – The Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey
Vincent – Baumgartner Restoration
Listener Pick J – Time, Einstein, and the coolest stuff in the Universe
Intro music is by Ronald Jenkees
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This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * What next for COVID-19 boosters? (NEJM) * Boosting with historical or variant mRNA vaccines (Cell) * Vaccination-infection interval determines antibody breadth (Cell Med) * Letters read on TWiV 890 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Webb Telescope’s coldest instrument reaches operating temperature
Brianne – Video of a CTL killing a tumor cell
Rich – Our Unfinished Pandemic (On the Media Podcast)
Vincent – Lý Thị Ca
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa.
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Links for this episode * Hospital admissions during Omicron and Delta variant outbreaks (Lancet) * Viral load in unvaccinated and vaccinated individuals (Nat Med) * Predictive Capability of symptoms in children (Clin Inf Dis) * Comparison of antigen tests (medRxiv) * Incidence of Myocarditis after COVID19 and non-COVID19 vaccination (Lancet) * Steroids during viral replication phase (Resp) * Paxlovid efficacy and safety (Pfizer) * Fluvoxamine & Outpatient Management (JAMA) * Sabizabutin efficacy and safety (Veru) * Colchicine and lack of benefit (Lancet) * SARS-CoV-2 prevalence in Africa (medRxiv) * Contribute to ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 889 33:35 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
Guest: Richard Plemper
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Links for this episode * Richard on TWiV 636 * Molnupiravir in ferrets (Nat Micro) * Oral prodrug of Remdesivir in ferrets (Nat Commun) * Letters read on TWiV 888 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – BioRender Poster Builder
Alan – Hexbug cat toys
Vincent – US Mint 2019 American Innovation Coin – PA – Polio Vaccine
Listener Picks Sue – American Visionary Art Museum
Frazer – Vaccine trial for killer elephant virus
Intro music is by Ronald Jenkees
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TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a major contributor to severe COVID-19.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episode * Seasonal influenza vaccine effectiveness (MMWR) * Properties of a dominant H3N2 variant (bioRxiv) * Scott Henley on influenza vaccine growth in eggs (TWiV 480) * Fc receptor dependent entry of SARS-CoV-2 into monocytes (Nature) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Ketanji Brown Jackson confirmed to US Supreme Court
Amy – Some threats just keep coming in waves
Rich – Lady Bird Johnson Wildflower Center
Vincent – Martijn Doolaard
Listener Picks Ann – Immunological memory to SARS-CoV-2 infection and vaccines
Chris – Isoplexis
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine dose in EU, dexamethasone dosing, immunomodulation therapy, MIS outcomes in children, US long COVID effort launched, and herd immunity.
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Links for this episode * Cardiac complications after infection or vaccination (MMWR) * Long COVID in children (Future Med) * Fourth vaccine dose in Israel (NEJM) * No need for fourth vaccine dose (Eur Med Agency) * Dexamethasone dosing (Intensive Care Med) * Actemra priority review (Roche) * Guidelines on anticoagulation therapy (American Soc Hematol) * MIS outcomes in children * in children (JAMA) * Biden launches long COVID effort (USA Today) * Herd immunity and COVID (J Inf Dis) * Contribute to ASTMH fundraiser at PWB * Dr. Griffin’s treatment guide (pdf) * Letters read on TWiV 886 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman primates from Delta infection.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episode * Sarbecovirus from Russian bat (bioRxiv) * MVA vectored COVID vaccine (Sci Immunol) * Letters read on TWiV 885 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Search for a Model Octopus That Won’t Die After Laying Its Eggs
Rich – Vaccine Pioneers and Opponents with Paul Offit (Podcast: Connected by Controversy by Chris White) and The Cutter Incident by Paul Offit
Vincent – Simply Put: Vaccines Save Lives
Listener Picks Rich – ‘Stolen’ Charles Darwin notebooks left on library floor in pink gift bag
Neva – Elin Thomas, UK textile artist
Viki – History of English Podcast
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.
Hosts: Vincent Racaniello and Amy Rosenfeld
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Links for this episode * Asthmatic bronchial smooth muscle and rhinovirus (Cell Rep) * SARS-CoV-2 ORF8 mimics IL-17 (mBio) * Letters read on TWiV 884 * Timestamps by Jolene. Thanks!
Weekly Picks Amy – Ben Franklin by Ken Burns
Vincent – Thoughts on a second booster: Offit and Krause/Borio
Listener Picks Philip – History of Clemson Blue Cheese
Jack – Pipeline and A Special Report on Polio
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning.
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Links for this episode * FDA authorizes second booster (FDA) * Second booster and mortality (Res Square) * Booster effectiveness vs hospitalization (MMWR) * SARS-CoV-2 confections (Lancet) * At-home testing (MMWR) * Transmission study in ferrets (PLoS Path) * Improving indoor air quality (EPA) * BCG vaccine no effect on viral infections (Clin Inf Dis) * Vaccination during pregnancy (JAMA) * mRNA vaccines and different Fc functions (Sci Transl Med) * Ivermectin clinical trial (NEJM) * Fluvoxamine clinical trial (Lancet) * Antiplatelet therapy (JAMA) * Aspirin and in-hospital mortality (JAMA) * Proning trial (Brit Med J) * Dr. Griffin's treatment guide (pdf) * Contribute to ASTMH fundraiser at PWB 41:20 * Letters read on TWiV 883 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of the inflammatory response to RNA vaccines.
Hosts: Vincent Racaniello and Brianne Barker
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Links for this episode * Understanding T cell responses during COVID-19 (Science Immunol) * IL-1 and IL-1ra are keys to inflammation after RNA vaccination (Nature Immunol) * Letters read on TWiV 882 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Covid restrictions prevented dengue in hundreds of thousands of people in 2020
Vincent – Scotch Dual Lock 250 Reclosable Fastener
Listener Picks Erin –JWT Preparation and Xploration Outer Space
Intro music is by Ronald Jenkees
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TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates viral disease in mice.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episode * Monoclonal antibody provides broad hantavirus protection (Sci Transl Med) * Prometheus Project (TWiV 578) * Oral antiviral related to Remdesivir (Sci Transl Med) * Letters read on TWiV 881 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – World’s tallest wooden building
Amy – Virus hunter in the Wuhan market
Rich – WorldPop (example)
Vincent – Karst Stone Paper
Listener Picks Neva – Can we vaccinate against EBV? and Paul Sutter reading a science paper
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia.
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Links for this episode * Moderna vaccine results in children (Moderna) * Delta/Omicron hospitalization by ethnicity (MMWR) * Intrinsic BA.2 severity in unvaccinated children (Lancet) * Children and COVID state-level data (AAP) * Placentitis and thrombohematoma during pregnancy (JAMA) * Predictive value of symptoms for diagnosis (Clin Inf Dis) * FDA to discuss booster strategy (FDA) * Evusheld activity against BA.1 and BA.2 (AstraZeneca and bioRxiv) * Remdesivir resistance in immunocompromised patient (Nature Comm) * Ivermectin for COVID with and without strongyloidiasis (JAMA) * Inhaled ciclesonide for outpatient treatment (Clin Micro Inf) * Home telemonitoring for infection (J Telemed Telecare) * Effectiveness of pulse oximetry in remote monitoring (Lancet) * Effects of anti-platelet therapy (JAMA) * COVID deaths in Zambia (medRxiv) * Contribute to ASTMH fundraiser at PWB * Letters read on TWiV 880 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * ASV 2022 * Emergence of remdesivir resistance (Nature Comm) * How to stall a copy machine (TWiV 819) * Omicron altered TMPRSS2 usage (Nature) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – NSURP 2022
Kathy – Virology Jobs
Rich – 10 Steps from Seed to Cup (Graphic)
Alan – Fathoms: The World in The Whale, by Rebecca Giggs
Vincent – Worldwaterday.org
Listener Picks Jeremy – Archaeology of Light
Intro music is by Ronald Jenkees
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TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may play a role in phenotypic diversity.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episode * CWD in meadow voles and raccoons (Emerg Inf Dis) * Unusual infectious agents (Virology Live) * Low fidelity influenza virus assembly (Cell) * Shape-shifting viruses (TWiV 743) * From variolous effluvia to VLPs (TWiV 170) * A pox on your horse (TWiV 478) * Letters read on TWiV 878 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – James Webb Space Telescope and Nature Conservancy Photo Contest
Amy – A new strategy for staying one step ahead of the virus
Rich – Searching for the origin of the smallpox vaccine: Edward Jenner and his little-known horsepox hypothesis
Vincent – Blacktail Studio
Listener Picks Richard – Water Structure and Science
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality.
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Links for this episode * Ivermectin did not reduce hospitalizations (Wall St J) * Increased hospitalization of children with Omicron (MMWR) * Seroconversion of children vs adults (JAMA) * Effectiveness of Pfizer-BioNTech vaccine in children (MMWR) * High vaccine effectiveness in Finland (medRxiv) * Distinct long COVID clinical phenotypes (Open Forum Inf Dis) * Estimating excess mortality (Lancet) * Contribute to ASTMH fundraiser at PWB * Letters read on TWiV 877 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Michael Worobey
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Links for this episode * Early COVID-19 cases in Wuhan (TWiV 833) * Huanan market was epicenter of COVID-19 (Zenodo) * Two spillover events launched COVID-19 pandemic (Zenodo) * Robert Malone and Peter McCullough: A litany of untruths (Decoding the Gurus) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Kartchner Caverns (info from Wikipedia here)
Kathy – Laminar flow and turbulent flow
Rich – Wikipedia
Vincent – The Human Lake by Carl Zimmer
Listener Picks Brad – NASASpaceflight
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.
Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld
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Links for this episode * WHO declaration of COVID-19 pandemic * Virome of China game animals (Cell) * ACE2 binding is ancestral and evolvable (Nature) * Letters read on TWiV 875 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Ship found at the bottom of the sea
Amy – Vaccinating kids has never been easy
Vincent – State data and CDC data on children and COVID-19
Listener Picks Andrew – Books by Randall Munroe
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI.
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Links for this episode * Infection and changes in brain structure (Nature) * Dementia among pneumonia survivors (Open Forum Inf Dis) * Narrative dynamics around COVID-19 vaccines (FSI) * Children and COVID (AAP) * Paxlovid in pediatric patients (Pfizer) * Mask effectiveness in schools (MMWR) * Host factors and severe disease (Nature) * Antiviral efficacy against BA.2 (NEJM) * Post-acute symptoms, Denmark (medRxiv) * Risk of sequelae after infection (BMJ) * CEPI (TWiV 612) * Contribute to ASTMH fundraiser at PWB * Letters read on TWiV 874 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Download TWiV 873 (128 MB .mp3, 107 min)
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Links for this episode * ABRCMS ePoster Spring Symposium for Emerging Scientists * Porcine coronaviruses (Virol Sin) * Mimivirus nucleocapsid (bioRxiv) * Letters read on TWiV 873 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Dinosaur Age May Have Ended in Springtime
Alan – The Track of the Typhoon, and me reading it.
Rich – 12 Monkeys
Vincent – Anna Mason’s Art Channel
Listener Picks Richard – SARS-CoV-2 in animals: Situation report #9
Jason – Counting App and CountThings from Photos
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID.
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Links for this episode * Vaccine effectiveness 5-11 year olds (medRxiv) * Vaccine effectiveness vs ED and UCE 5-12 year olds (medRxiv) * Children affected by COVID (Lancet) * Accuracy of rapid antigen tests (medRxiv) * COVID community levels (CDC) * Therapeutics guidelines (WHO) * Mortality among SOT (Clin Inf Dis) * Long COVID after two vaccine doses (medRxiv) * Peripheral neuropathy in COVID patients (Neurology) * Letters read on TWiV 872 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
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Links for this episode * ABRCMS ePoster Spring Symposium for Emerging Scientists * ASV Annual Meeting Registration (ASV) * Microbiology & Immunology at LSU Health * Is Omicron a new serotype? (Nat Rev Micr) * Adaptation of SARS-CoV-2 to mink/ferret (Cell Rep) * Letters read on TWiV 871 * Timestamps by Jolene. Thanks!
Weekly Picks Alan – Which Immune Cell Are You? and Michaeleen Doucleff’s article
Rich – Vaccinated: One Man’s Quest to Defeat the World’s Deadliest Diseases by Paul A. Offit
Vincent – Ebola on Canvas
Listener Picks Les – Ologies podcast
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfection prevents disease in hamsters, repeated infections with endemic coronaviruses, global burden of antimicrobial resistance, ivermectin not protective in hamsters, and Omicron evades therapeutic monoclonals.
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Links for this episode * What does society owe immunocompromised people (Atlantic) * Prevalence of immunosuppression in US (JAME) * Hospitalizations of children (MMWR) * Clinical considerations for vaccines (CDC) * Sanofi seeks vaccine approval (Sanofi) * Omicron triggers cross-reactive neutralization (medRxiv) * Reinfection prevents disease in hamsters (Cell) * Repeated infections with endemic CoV (J Inf Dis) * Global burden of antimicrobial resistance (Lancet) * Ivermectin not protective in hamsters (bioRxiv) * Omicron evades therapeutic monoclonals (bioRxiv) * Letters read on TWiV 870 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein, leading to multiple sclerosis.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * ABRCMS ePoster Spring Symposium for Emerging Scientists * ASV Annual Meeting Registration (ASV) * Microbiology & Immunology at LSU Health * Viremia in human poliomyelitis (J Exp Med) * EBV associated with MS (Science) * MS antibodies Bind EBV EBNA1 and GlialCAM (Nature) * Letters read on TWiV 869 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Rapid intensification of the emerging southwestern North American megadrought in 2020–2021
Brianne – Which Immune Cell Are You?
Rich – Nikola Tesla – 3D Anamorphosis
Vincent – Paul’s Uncle Doesn’t Want to Get Vaccinated
Listener Picks Bob – The 1969 Apollo Guidance Computer
Anne – Decoding the Gurus with Dan Wilson
Beth – FrenchGuyCooking
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates, booster safety among adults, placentitis, azithromycin, oral Nirmatrelvir, Omicron antibody evasion, EUA for bebtelovimab, IL-1 blocking agents, thromboprophylaxis, effectiveness of vaccines against long COVID, and risks of mental health outcomes.
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Links for this episode * Children and COVID state data (AAP) * Effectiveness of maternal vaccination (MMWR) * Vaccines for immunocompromised (CDC) * PCP and vaccination rates (JAMA) * Booster safety among adults (MMWR) * Placental tissue destruction and placentitis (Arch Path Lab Med) * Azithromycin meta-analysis (J Antimicrob Chemo) * Oral Nirmatrelvir for high-risk, nonhospitalized adults (NEJM) * Omicron antibody evasion (bioRxiv) * EUA for bebtelovimab (FDA) * IL-1 blocking agents (Cochrane) * Thromboprophylaxis (Chest) * Effectiveness of vaccines against long COVID (UK Health) * COVID complications in Australia (Lancet) * Risks of mental health outcomes (BMJ) * Letters read on TWiV 868 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Dorothy Horstmann (Wikipedia) * Intranasal SARS-CoV-2 experimental vaccine (Cell) * t-SNE (Wikipedia) * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – 477-mile-long megaflash lightning in Seattle Times (originally Washington Post) and extra info from Rich World Meteorological Org
Rich – NIAID Global Research (Mali)
Alan – New method for recycling electric car batteries
Vincent – Q&A with A&V
Listener Picks Addie – Vaccine Podcast
Jennie – Dr. Katelyn Jetelina, aka Your Local Epidemiologist
Intro music is by Ronald Jenkees
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Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld
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Links for this episode * ABRCMS ePoster Spring Symposium for Emerging Scientists * Cross-reactive enterovirus antibodies (mBio) * Poliovirus receptor transgenic mice (virology blog) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – European scientists set new record in production of nuclear fusion energy
Amy – Alfredo’s Magic Wand
Brianne – What Happened After the Chicken-Pox Vaccine?
Rich – Year Three of COVID-19: Harsh Truths, Realities, and Glimmers of Hope
Vincent – Economists Are Fueling the War Against Public Health
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, long-term cardiovascular outcomes, and global vaccine perceptions.
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Links for this episode * Children and COVID state data (AAP) * Human challenge study (Res Sq) * Effectiveness of mask use (MMWR) * Omicron boost in macaques (bioRxiv) * Mucosal vaccine candidate (Cell) * Long-term cardiovascular outcomes (Nat Med) * Global vaccine perceptions (PLoSNTD) * Letters read on TWiV 865 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or other animals.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guests: John Dennehy, Marc Johnson, Davida Smyth, and Monica Trujillo
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Links for this episode * SARS-CoV-2 in NYC wastewater (TWiV 737) * Cryptic SARS-CoV-2 in NYC wastewater (Nat Comm) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – When scientific conferences went online, diversity and inclusion soared
Rich – Traffic flow measured on 30 different 4-way junctions
Vincent – A Slot Machine, a Broken Test Tube by S.E. Luria
Intro music is by Ronald Jenkees
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TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of symptoms, and reliability of lateral flow antigen assays.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * Vaccine Town Hall (ASV) * Columbia University BSL-3 Manager position 3:27 * UK SARS-CoV-2 challenge study (Res Sq) * U of Pennsylvania smell test (Wikipedia) * Letters read on TWiV 863 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Webb team begins aligning telescope
Brianne – Our Solar System in True Color Is Really Something Else
Rich – When the International Space Station retires, it will plunge into the ocean to die
Vincent – Gateway Program and What One Really Expensive Means to US Train Travel
Listener Picks Jack – Dr. Becky and Pasta or composer
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under 5 year olds, false positives from soft drinks, Novavax vaccine EUA application, childhood experiences and vaccine hesitancy, fourth vaccine dose in Israel, effects of antivirals and monoclonals against Omicron, and multiple factors associated with PASC.
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Links for this episode * Omicron severity challenges (NEJM) * Children and COVID data (AAP) * Vaccine EUA for under 5 year olds (Pfizer) * B cell boot camp (Immune 52) * Soft drink and LFA false positives (medRxiv) * EUA application for Novavax vaccine (Novavax) * Childhood experiences and vaccine hesitancy (BMJ Open) * Fourth vaccine dose in Israel (medRxiv) * Antibodies and antivirals vs Omicron (NEJM) * Paxlovid and Omicron (Pfizer) * Multiple factors and PASC (Cell) * Internship at Parasites Without Borders (pdf) 28:47 * Letters read on TWiV 862 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Nels Elde
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Links for this episode * Vaccine Town Hall (ASV) * Columbia University BSL-3 Manager position * Did Omicron come from mice? (J Genet Genomics) * Persistent SARS-CoV-2 infection (SSRN) * Letters read on TWiV 861 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Groundhogs Emerge From the Scientific Shadows
Kathy – Zig-zag Coast Guard search pattern
Rich – Moon Phases 2022 (Lunar Reconnaissance Orbiter)
Vincent – Kevin Cowtan’s Book of Fourier and Live Fourier Transformation
Nels – Biology versus bias
Listener Picks Dusty – Fighting bias in space
Intro music is by Ronald Jenkees
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TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA vaccines.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episode * Vaccine Town Hall (ASV) * Columbia University BSL-3 Manager position * RNA modifications suppress innate recognition (Immunity) * Critical contribution of pseudouridine (Front Cell Dev Biol) * Rich Condit reminisces (YouTube) * Letters read on TWiV 860 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson - NASA Research Launches a New Generation of Indoor Farming Kathy -How Pfizer scientists transformed an old drug lead into a COVID-19 antiviral Rich - Fermi paradox Vincent - Racism not Race by Joe Graves
Listener Picks Jay – Restoration of Ave Maria
John – Pandemic humor
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD, booster efficacy for ED and UC encounters, vaccines induce cross-protective T cell memory, and indications for monoclonal antibody therapy.C
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Links for this episode * Omicron disease severity (MMWR) * Neurologic manifestations in children (Pediatric Neurol) * Respiratory virus interference (Emerg Inf Dis) * Hospitalization by vaccination status (CDC) * Third vaccine dose VE (MMWR) * Vaccination induces cross-reactive T cells (Cell) * Limitations for monoclonal antibody use for Omicron (FDA) * Internship at Parasites Without Borders (pdf) 42:40 * Letters read on TWiV 859 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Guest: John Mascola
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Links for this episode * Accelerated COVID-19 vaccine development (Immunity) * Letters read on TWiV 858 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – How Sesame Street is Handling the Pandemic
Rich – Zamboni: How it works
Alan – How lightning starts
Vincent – Buon-A-Petitti
Listener Picks Meika –Wordle
Intro music is by Ronald Jenkees
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Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Jon Yewdell
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Links for this episode * Jon Yewdell on TWiV 208, 467, 597, 620 * Letters read on TWiV 857 * Timestamps by Jolene. Thanks!
Weekly Picks Jon – The Premonition by Michael Lewis
Dickson – Nature photographer of the year 2021
Brianne – Should BioBank Volunteers Be Warned About Mutations?
Rich – Czech singer Hanka Horká dies after intentionally getting infected by the coronavirusand Dena Dietrich Dies at 91
Vincent – Cuore di Cioccolato
Listener Picks Bronwen – Schools must stay open
John – Pandemic humor
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic.
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Links for this episode * COVID-19 in South Africa (pdf) * Ancestral T cells recognize Omicron (Nat Med) * Booster effectiveness against COVID-19, England (Nat Med) * Cases and hospitalization by vaccination status (MMWR) * Infection and vaccination in pregnant women, Scotland (Nat Med) * Early Remdesivir to prevent progression to severe disease (NEJM) * Management of hospitalized adults (NIH) * Tocilizumab in hospitalized patients (Resp Care) * Vaccination and long COVID in Israel (medRxiv) * Pandemic true death toll (Nature) * Internship at Parasites Without Borders (pdf) * Letters read on TWiV 856 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Alessandro Sette
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Links for this episode * Travel Award Applications (ASV) 3:20 * Impact of variants on T cells (Cell Rep Med) * Timestamps by Jolene. Thanks! * Letters read on TWiV 855
Weekly Picks Brianne – 75 years of research on human diseases in 1 minute
Kathy – 10 second video of COVID-19 spread
Rich – Diffraction spike
Vincent – John’s Furniture Repair and Transcend Furniture Gallery
Listener Picks Alison – FDA drug shortages
Ingrid – One woman’s mission to get vaccines to her rural Alabama town
Intro music is by Ronald Jenkees
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TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patients infected with wild type, Delta and Omicron viruses reveals lack of correlation with RNA loads determined by RT-PCR, similar levels of shedding among Delta and Omicron, and greatly reduced shedding in vaccinated people.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Travel Award Applications (ASV) 2:11 * Omicron transmission in Danish households (medRxiv) * Infectious viral load in vaccinated and unvaccinated patients (medRxiv) * Fred Murphy on TWiV 625 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Favorite Science Photos of 2021
Brianne – Viruses, Vaccines, and COVID-19 videos from American Museum of Natural History
Kathy – Klompas et al. “Current insights into respiratory virus transmission…”
Rich – Leviathan Falls by James S.A. Corey
Vincent – Ebola (1996) by David Molesky at The Incubator
Listener Picks Randall – Robert Malone & Peter McCullough: A litany of untruths
Suellen – Omicron and the case of the hidden evolution – Understanding Evolution
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid antigen tests, booster interval shortened to 5 months, risk factors for severe outcomes in vaccinated, cross-reactive memory T cells, vaccine effectiveness vs MIS-C, and Rivaroxiban for thromboprophylaxis.
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Links for this episode * Quarantine and isolation (CDC) * Outcomes before and after Omicron (medRxiv) * Infectious viral load in Delta vs Omicron infections (medRxiv) * PCR vs rapid antigen test (medRxiv) * Booster interval to 5 months (FDA) * Cross-reactive memory T cells (Nat Comm) * Risk factors for severe outcomes in vaccinated (MMWR) * Vaccine effectiveness vs MIS-C (MMWR) * Cross-reactive T cells to Omicron from vaccines (medRxiv) * Rivaroxiban for thromboprophylaxis (Lancet) * Letters read on TWiV 853 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episode * Vaccine Town Hall (ASV) * Travel Award Applications (ASV) * CD28 deficiency and severe warts (Cell) * Vincent interviews Harald zur Hausen (virology blog) * Letters read on TWiV 853 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Every Pore on Your Face Is a Walled Garden
Rich – “On Warts” by Lewis Thomas (Pdf)
Vincent – Cells at Work Code Black 1
Listener Picks Chris – Ria Lina on the Guilty Feminist podcast
Duncan – Meet the green kleptos of the animal kingdom
Intro music is by Ronald Jenkees
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The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld
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Links for this episode * Vaccine Town Hall (ASV) * Travel Award Applications (ASV) * Omicron infection in mice and hamsters (Res Square) * Letters read on TWiV 851 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Engineering the James Webb Space Telescope
Amy – T cells might be our bodies’ best shot against Omicron
Brianne – Where is Webb?
Rich – First U.S. vaccine mandate in 1809 launched 200 years of court battles
Vincent – The Secret of Life by Howard Markel
Listener Picks Jen – Antidote
David – Rosie Revere, Engineer
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID.
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Links for this episode * Variant proportions (CDC) * Omicron in South Africa (JAMA) * Transmission of SARS-CoV-2 (Ann Int Med) * Diagnostics for COVID-19 (Lancet) * Comparison of rapid antigen tests (J Clin Med) * Rapid antigen tests to reduce isolation (medRxiv) * Frequency of viral confections (MMWR) * Isolation and quarantine (CDC) * Saliva preferred for Omicron (medRxiv) * Risk factors for severe COVID in vaccinated (MMWR) * Paxlovid dosing (Pfizer) * Fatigue and cognitive impairment (Brain, Behavior, Immune) * Letters read on TWiV 850 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * COVID vaccines: TWiV 708, 715, 718, 844 * Non-CoV papers: TWiV 763, 784, 819, 822, 740, 848 * Immune correlates of protection: TWiV 791, 799, 835, 832, 841, 789 * Fitness: TWiV 705, 836, 768, 757 * Guests off beaten track: 723, 726, 732, 838, 773, 745 * Lab leak nonsense: TWiV 762, 774 * One Health/Viruses in Wildlife: TWiV 799, 722, 771, 809, 798, 759, 791, 847, 750, 821, 824, 804 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Don’t Look Up
Kathy – spaceweather.com
Rich – Video of a Green Flash (wiki)
Alan – Fungally-modified violins
Vincent – This Old Tony especially this segment
Listener Picks Paul – Deep Mind and AlphaFold
Grant – SARS-CoV-2 reproduction cycle
Intro music is by Ronald Jenkees
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For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging white-tailed deer.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Codon-deoptimized Lassa fever vaccine (mBio) * Attenuation of dengue virus by codon deoptimization (TWiV 351) * Codon deoptimization of poliovirus and RS virus (TWiV 740) * Codon deoptimization of DNA viruses (TWiV 362 letters) * CEPI on TWiV 612 * SARS-CoV-2 in white-tailed deer (Nature) * Letters read on TWiV 847 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – EO Wilson (Ants and The Conversation)
Brianne – The Best Fun Science Stories of 2021
Kathy – Using sound for data analysis; chemotactic bacteria and Moo loo story
Alan – Owls of the Easern Ice, by Jonathan Slaght
Vincent – TWiV 9: Fever! The discovery of Lassa virus and TWiV 548: Mice, shrews, and caterpillars
Listener Picks Larry – Immunity
Jeff – Daily Hospital Surveillance Report
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron outbreaks in Nebraska and Denmark, Baylor's COVID vaccine, and COVID-OUT for ivermectin.
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Links for this episode * Isolation and quarantine guidance (CDC) * EUA for Molnupiravir (FDA) * Children and COVID state data (AAP) * Vaccine safety in 5-11 year olds (MMWR) * Omicron and antigen tests (FDA) * Omicron in Nebraska (MMWR) * Omicron in Danish households (medRxiv) * Baylor COVID vaccine (TCH) * COVID-OUT for ivermectin (U Minn) * Letters read on TWiV 848 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mice.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Impact of enteric virome on rotavirus vaccine (Cell Host Micr) * Beta variant infects wild type mice (Sig Transd Targ Ther) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – XKCD on Immune Responses and Immunity
Kathy – UVA Rotunda astrophotograph with Heart and Soul Nebulae by Brennan Gilmore
Rich – James Webb Space Telescope Videos: 29 Days On The Edge; Launch And Deployment
Alan – Sokobond puzzle game
Vincent – International Space Station shines in gorgeous fly-around photos by Crew Dragon astronauts
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines, Molnupiravir in non-hospitalized patients, and convalescent serum in outpatients.
Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episode * FDA EUA for Paxlovid (pdf) * Children and COVID-19 (pdf) * Evaluation of test to stay in school, IL (MMWR) * Evaluation of test to stay in school, LA (MMWR) * Update on mRNA vaccine in under 5 yo (Pfizer) * CDC endorses preference for mRNA vaccines (CDC) * Natural immunity and protection against delta (Clin Inf Dis) * Cross-neutralization post-vaccination infection (JAMA) * Variants and therapeutics (NIH) * Quarantine and isolation (CDC) * Molnupiravir in non-hospitalized patients (NEJM) * Convalescent serum for outpatients (medRxiv) * Letters read on TWiV 845 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkee
Send your questions for Dr. Griffin to daniel@microbe.tv
Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guest: Paul Offit
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Links for this episode * Paul Offit on TWiV 720 * Are COVID-19 vaccine boosters needed? (virology blog) * Letters read on TWiV 844 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne - Virus snowflakes
Dickson - The Year in Pictures 2021
Vincent - Our Life is Plasticized
Listener Picks Gerry - Dan Barouch: COVID-19 Vaccine Development
Louise - Pandora's Lab by Paul Offit
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Variant updates (CDC) * List of diagnostic kits (Global Fund, pdf) * B1.1.529 escapes most antibodies (bioRxiv) * mRNA vaccine third dose and Omicron (medRxiv) * Outpatient strategies children and adolescents (AAP) * Memory B cells persist in elderly (J Clin Invest) * mRNA booster effect against Delta (Clin Inf Dis) * Azithromycin meta-analysis (J Antimicrob Chemo) * High-flow oxygen vs intubation (JAMA) * Therapeutic anticoagulation (Ann Int Med) * Africa cases surge (CIDRAP) * Letters read on TWiV 843 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovirus capsid, suggesting a mechanism for thrombosis with thrombocytopenia syndrome.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
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Links for this episode * Third vaccine dose improves Omicron neutralization (medRxiv) * ChAdOX1 interacts with PF4 (Sci Adv) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Vaccine Scientists: Time’s 2021 Heroes of the Year
Kathy – Snake dietary diversity
Vincent – Alfred Wegener Institute on Instagram
Listener Picks Niclas – Once upon a time… Life
Intro music is by Ronald Jenkees
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TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in the upper and lower respiratory tract of nonhuman primates.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episode * Omicron escape from serum antibodies (pdf) * Pfizer/BioNTech update on Omicron (Pfizer) * Randomized trial of masking for COVID-19 (Science) * Upper and lower respiratory tract correlates of protection for RS virus (Cell Host Micr) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Cities at Night
Amy – I’m an E.R. Doctor in Michigan, Where Unvaccinated People Are Filling Hospital Beds
Rich – International Dark Sky Association
Vincent – SARS-CoV-2 variants
Listener Picks Keith – Ventusky
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, FDA EUA for pre-exposure prophylaxis, outcomes after treatment, and investigation of subcutaneous or intramuscular administration; effect of adding immunomodulatory agents to usual care on thromboembolic events, and long COVID following infection in previously vaccinated individuals.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Risk associated with Omicron (medRxiv) * Expansion of monoclonal EUA (FDA) * Neutralization of Omicron by sera (medRxiv) * Third dose sera neutralize Omicron (Pfizer) * Monoclonals authorized for PreP (FDA) * Patient outcomes after monoclonals (Open Forum Inf Dis) * Subcutaneous or intramuscular monoclonals (medRxiv) * WHO does not recommend convalescent serum (WHO) * Immunomodulation and thromboembolic risk (J Clin Med) * Long COVID after infection of vaccinated (medRxiv) * Letters read on TWiV 840 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162b2 vaccine is better than a shorter interval.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Coronavirus in the US (NY Times) * Omicron variant (NY Times) * West Nile virus transmission by organ transplantation (Emerg Inf Dis) * Stronger antibody response after 16 week mRNA dose (Cell Host Micr) * Higher antibody response with 7 week dosing (Clin Inf Dis) * Immune response after recovery and 1 vaccine dose (Sci Transl Med) * Booster guidance in Canada (pdf) * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – CDC U-M flu report (lay version, MMWR)
Rich – Thagomizer
Alan – Descent into Darkness by Edward Raymer
Vincent – Funding: Blinding peer review
Listener Picks Lynne – ACE2 in chewing gum
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on variant of concern Omicron.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Teresa Bautista, Isabel Francisco, Jesus Gonzales, Joel Gonzalez, Florian Krammer, and Christine Marizzi,
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Links for this episode * Biobus * Wild Bird Fund * FluLab * B1.1.529 (COVID-19-lineages) * Report on Omicron spike changes (virological) * Omicron (Wikipedia) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Plant Habitat-04
Brianne – The Coronavirus in a Tiny Drop
Rich – Prophet in Purgatory by Jon Cohen
Vincent – “ ’—All You Zombies—’ ” by Robert A. Heinlein (pdf)
Listener Picks Mike – The Coronavirus in a Tiny Drop
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques, peptide for induction of T cell immunity, high respiratory viral RNA loads in infants, IgA and T cells transferred to breast milk after vaccination, sensitivity and specificity of ID NOW, post-acute sequelae at 12 months, disease in low and middle income countries.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Update on Molnupiravir results (Merck) * Omicron (Wikipedia) * P681H and IFN resistance (bioRxiv) * Synthetic DMARDS and disease severity (Ann Rheum Dis) * Recovery in T cell depleted macaques (mBio) * T-cell inducing peptide (Nature) * Respiratory viral RNA load in infants (J Inf Dis) * IgA and T cells in breast milk (Cell Rep) * ID NOW specificity and sensitivity (J Clinical Viral) * Risk prediction algorithm (Thorax) * PASC in adults at 12 months (Front Med) * Letters read on TWiV 837 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cells in culture and induce membrane fusion.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Omicron genome changes (Covariants) * Omicron shared changes with other variants (Covariants) * Update on Omicron (WHO) * Spike polymutant PMS20 (bioRxiv) * Syncytium formation of variants of concern (EMBO J) * Variants as super cell fusers (EMBO J) * Letters read on TWiV 836 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Immune
Kathy – Elizabeth Lee Hazen and Rachel Fuller Brown, discoverers of nystatin oneand two
Alan – Four Lost Cities by Analee Newitz
Vincent – Deadly Choices by Paul Offit
Listener Picks Ryan – Ronny Jackson (one and two)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
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Links for this episode * COVID-19 vaccines for children (Science) * Risk of infection with variants (medRxiv) * Immune correlates of mRNA-1273 (Science) * Letters read on TWiV 835 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Pee Wee Herman aka Paul Rubens
Brianne – APOD: Pleiades
Vincent – A History of Poliomyelitis by JR Paul
Listener Picks Richard – Let’s talk about a familiar problem and a new tactic….
Sherri – Have the New Jab
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Expanded eligibility for booster doses (FDA) * More rapid antigen tests approved (FDA) * Immune correlates for mRNA-1273 (Science) * Risk for still birth with and without COVID-19 (MMWR) * PROVENT phase III prophylaxis trial (AstraZenica) * Fluvoxamine guidelines (IDSA) * COVID-OUT trial (Univ Minnesota) * Monoclonal antibody treatment in vaccinated infected (J Inf Dis) * Steroid use in non-oxygen requiring patients (QJM) * Doxycycline trial (Lancet) * Efficacy of inhaled ciclesonide (JAMA) * Advise on use of molnupiravir (EMA) * Text messaging for monitoring disease (Ann Int Med) * Long COVID after vaccination and infection (Res Square) * Ivermectin for West Nile virus (Medpage Today) * Letters read on TWiV 834 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episode * Early COVID-19 cases in Wuhan (Science) * Herpesviruses assimilate kinesin (Nature) * Letters read on TWiV 833 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Power of poop
Alan – Under the Sky We Make, by Kimberly Nicholas
Vincent – Enzymatic amplification of beta-globing sequences
Listener Picks Paula – Reasons to be Cheerful and The Night Witches by Bruce Myles
Grant – George Carlin – Germs, Immune System
Intro music is by Ronald Jenkees
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TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episode * Smallpox vials contain vaccinia virus (6abc.com) * European re-emergence of enterovirus D68 (Eurosurveill) * Efficacy of inactivated SARS-CoV-2 vaccine (Lancet) * Cellular correlates of protection for oral flu vaccine (Cell Host Micr) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Rodney Dangerfield
Amy – Calder at MoMA
Rich – ‘Useless Specks of Dust’ Turn Out to Be Building Blocks of All Vertebrate Genomes
Vincent – Structure of small viruses
Listener Picks Charles – It is raining you lied to me
Dave – A Whole New Ball Game
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Scott Hammer on TWiV 52 * Meeting for molnupiravir EUA (FDA) * SARS-CoV-2 reinfection associates with antibodies (Clinical Inf Dis) * AFM surveillance in US (CDC) * Monoclonal antibody treatment in high-risk patients (J Inf Dis) * Letters read on TWiV 831 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Download TWiV 830 (67 MB .mp3, 112 min)
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Links for this episode * Spike protein inhibition of V(D)J recombination in vitro (Viruses) * Evolutionary predictability of SARS-CoV-2 (PLoS Path) * Letters read on TWiV 830 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – When do we get back to normal? Maybe now.
Rich – The Covid-19 Pandemic
Alan – Yaupon Brothers American tea
Vincent – Cracking the genetic code (and Niremberg’s account)
Listener Picks Justin – Partisan vaccination
Lisa – The Red Flag
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19.
Hosts: Vincent Racaniello and Brianne Barker
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Links for this episode * How SARS-CoV-2 attacks olfactory mucosa (Cell) * SARS-CoV-2-specific stem cell memory T cells after mRNA vaccine (Sci Immunol) * Oral SARS-CoV-2 protease inhibitor (Science) * Paxlovid phase 2/3 trial preliminary results (Pfizer) * Letters read on TWiV 829 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Coronavirus Neutralizing Antibodies and mRNA Vaccine Video
Vincent – MHC restriction of cytotoxic T cell lysis (Nobel description)
Listener Picks Lisa – Shall Furnish Medicine
Bistra – Saving the World by Julia Alvarez
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Vaccine protection of US veterans (Science) * Long term protection by REGEN-COV (Regeneron) * Pfizer protease inhibitor Paxlovid phase 2/3 results (Pfizer) * Letters read on TWiV 828 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambitions, ego, and a desire to save the world.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Greg Zuckerman
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Download TWiV 824 (76 MB .mp3, 127 min)
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Links for this episode * A Shot to Save the World (Hardcover, Kindle) * Letters read on TWiV 827 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Michael Palin
Kathy – Science News Centennial
Rich – Diverse variola virus (smallpox) strains were widespread in northern Europe in the Viking Age
Vincent – Evidence for somatic rearrangement of immunoglobulin genes (and commentary)
Listener Picks Matt – Clinical evidence that the pandemic from 1889 to 1891 commonly called the Russian flu might have been an earlier coronavirus pandemic
Brigitte – The Obscure Virus Club
Justin – Eddie Holmes wins Prime Minister’s Prize for Science
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #87, Dr. Griffin reviews PCR cycle threshold and RNA copy number, rapid antigen tests, hospitalization rate after infection or vaccination, allergies and vaccination, community transmission and viral RNA load, early treatment with sotrovimab, meta-analysis of tocilizumab treatment, antibiotic overuse, and guidelines on the use of anticoagulation for thromboprophylaxis.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * CDC vaccine nod to 5-11 year olds (CDC) * Sensitivity of rapid antigen tests (Front Micro) * COVID-19 among infected or vaccinated (MMWR) * Allergy and vaccination symptoms (JAMA) * Community transmission and viral RNA load (Lancet) * Early treatment with sotrovimab (NEJM) * Tocilizumab treatment meta-analysis (Leukemia) * Antibiotic overuse in COVID-19 (Am J Trop Med Hyg) * Anticoagulants for thromboprophylaxis (Blood Adv) * Letters read on TWiV 826 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In this special live-streamed episode of TWiV, Dr. Daniel Griffin fields questions on SARS-CoV-2 and COVID-19 from listeners.
Hosts: Daniel Griffin and Vincent Racaniello
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Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccination of nonhuman primates.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * HA and NA of Wuhan spiny eel influenza virus (Nat Comm) * Protection one year after mRNA-1273 vaccination (bioRxiv) * Letters read on TWiV 824 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Best of Gilda Radner
Brianne – This polio survivor is one of the last still relying on an iron lung
Rich – WHO Announces Proposed Members of its Scientific Advisory Group for the Origins of Novel Pathogens (SAGO); (members)
Vincent – Discovery of mRNA (paper one and two)
Listener Picks Doris – History of smallpox and smallpox vaccine
Judith – How the immune system works
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #86, Dr. Griffin discusses virologic features of infection in children, antibody tests should not be used to asses level of protection, test-to-stay programs in schools, FDA authorizes Moderna boosters, results of TOGETHER trial for fluvoxamine, statins and 28 day mortality, and cognitive function in patients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * 115,000 healthcare worker deaths (Stat News) * Virology features of infection in children (J Inf Dis) * Antibody tests not for assessing protection (FDA) * Infections in vaccinated healthcare workers (NEJM) * Flawed science of antibody testing (JAMA) * Test-to-stay in school (US News) * Vaccination and non-COVID mortality risk (MMWR) * EUA for Moderna booster (FDA) * Fact sheet for use of casirivimab and imdevimab (FDA) * Effect of early treatment with fluvoxamine (Lancet) * Statins and 28-day mortality (J Inf Dis) * Cognitive function after COVID-19 (JAMA) * Routine vaccination coverage worldwide (MMWR) * Letters read on TWiV 823 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox virus infection to ~600–1050 CE, overlapping the Viking Age.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Variola virus genomes from Viking era (Science) * Hidden history of ancient plagues (Nature) * Was smallpox a mild disease? (Science) * Smallpox: Ten years gone (Am J Pub Health) * Myth of the milkmaid (NEJM) * Interview with DA Henderson (ASM) * Letters read on TWiV 822 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Animal Kingdom is Full of Genetic Screwballs
Kathy – Science dresses, accessories from Svaha and Rosalind Franklin’s DNA diffraction dress
Rich – The Saxon Stories
Alan – Cincinnati’s “Old Cunny,” and audiobook version
Vincent – Infectious QBeta viral DNA
Listener Picks Jeff – The unvaccinated may not be who you think
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses from bats.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episode * Bat and rodent paramyxoviruses from Arizona (J Viral) * Naive B cells engage SARS-CoV-2 RBD (Science Immunol) * Vincent interviews Philip Sharp (ASM) * Letters read on TWiV 821 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Apod: The Dolphin Head Nebula
Rich – The Tree That Could Help Stop The Pandemic; Elucidating the Mechanisms of Action of Saponin-Derived Adjuvants
Vincent – Discovery of RNA splicing in Sharp and Roberts laboratories
Listener Picks Jason – Home Assistant
Alena – VirusCraft
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune responses after vaccination, Moderna booster dose approved, giving monoclonals at home, no benefit from colchicine, and IFN does not help remdesivir.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Guidelines on COVID-19 drugs (WHO) * Holiday celebrations (CDC) * COVID-19 cases and deaths by vaccination status (CDC) * Effectiveness of Pfizer-BioNTech mRNA Vaccination 12-18 years (MMWR) * Rollout of vaccines for 5-11 year olds (WaPo) * Standard and extended dosing mRNA vaccine (Cell) * Differential kinetics immune responses after vaccination (NEJM) * Moderna booster dose approved (FDA) * Vertically transferred maternal immune cells (Nat Comm) * Giving monoclonals at home (JAMA) * No benefit from colchicine (Lancet) * IFN does not help remdesivir (Lancet) * Letters read on TWiV 820 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm) * Movie of polymerase stalling (Nat Comm) * Second mechanism of remdesivir inhibition (J Biol Chem) * Watson Crick molecular model (Science Museum Group) * Letters read on TWiV 819 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Great Lakes Science Center, Cleveland
Rich – How to Temporarily Disable Your Keyboard with a Keyboard Shortcut in Windows
Alan – How to Make a Slave and Other Essays by Jerald Walker
Vincent – A structure for deoxyribose nucleic acid
Listener Picks Steve – How the immune system actually works
Lise – Lise Meitner: A Life in Physics
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metabolite of molnupiravir, causes mutations in cellular DNA.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Efficacy and safety of Novavax vaccine (medRxiv) * A floret of spikes with Matt Frieman (TWiV 729) * Maternal SARS-CoV-2 infection affects neonatal immunity (Nat Immunol) * NHC is mutagenic in mammalian cells (J Inf Dis) * Coding for catastrophe (Nat Struct Mol Biol) * Molnupiravir development (Nature) * Letters read on TWiV 818 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – John Clease
Brianne – Astronomy Picture of the Day: Swirl in the Southern Sky
Kathy – Lise Meitner Statue is at the Humboldt University
Rich – Google has the cleanest cloud. Now it’s helping other companies go green
Vincent – Discovery of reverse transcriptase by Baltimore and Temin
Listener Picks Sam – Air Travel Packing List
Justin – PFAS: Last Week Tonight with John Oliver and EPA targets greenhouse emissions
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for molnupiravir, phase 3 results of AZD7442, serum ferritin levels and outcomes, heparin therapy, and WHO strategy for global vaccination.
Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Antibody profiles after mRNA vaccination in children (bioRxiv) * Novavax vaccine phase 3 results (medRxiv) * Heterologous vaccine boosters (medRxiv) * Antithrombotic therapy outcomes (JAMA) * Molnupiravir EUA submitted (Merck) * AZD7442 phase 3 results (AstraZeneca) * Serum ferritin levels and disease outcome (JAMA) * Heparin efficacy (JAMA) * WHO strategy to vaccinate world (WHO) * Letters read on TWiV 817 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long COVID.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episode * Call me David Tuller (TWiV Special) * David writes at virology blog * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler
Guests: Moshe Arditi and Ivet Behar
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Links for this episode * MIS-C in US children (NEJM) * Superantigen in spike and T cell skewing in MIS-C (PNAS) * MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol) * Antibody against bacterial superantigen blocks SARS-CoV-2 entry (Structure) * Autoimmune signature of MIS-C in children (J Clin Invest) * HLA1 associated T cell expansion in MIS-C (J Clin Invest) * Passing of Bill Wold (one, two) * Letters read on TWiV 815 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Mel Brooks
Kathy – Dickson’s art show at Fordham
Rich – Saildrone captures footage from inside Hurricane Sam
Vincent – A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman
Listener Picks Kathryn – Project Drawdown and the book
Charles – Arrowsmith by Sinclair Lewis
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccination on transmission, AZD7442 request for EUA filed, EUA issued for home antigen test, phase 3 data on AZD1222 vaccine, 6 month effectiveness of Pfizer/BioNTech vaccine, estimates of durability of immunity against reinfection, Molnupiravir interim results, optimal time for monoclonal antibody infusion, IVIG plus Infliximab for MIS-C, and effect of vaccination on long COVID.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Preventing transmission at camps (MMWR) * Outbreaks at summer camps (MMWR) * Impact of vaccination on transmission (medRxiv) * AZD7442 request for FDA EUA (AstraZeneca) * FDA EUA for home antigen test (FDA) * Phase 3 results AZD1222 vaccine (NEJM) * 6 month effectiveness BNT1`62b2 vaccine (Lancet) * Durability of immunity vs reinfection (Lancet) * Molnupiravir interim results (Merck) * Optimal time for mAb therapy (Inf Dis Advisor) * IVIG plus Infliximab for MIS-C (Pediatrics) * Effect of vaccination on long COVID (Lancet preprint) * Letters read on TWiV 814 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how to prepare for the next one.
Host: Vincent Racaniello
Guests: Sarah Gilbert, Florian Krammer, Fausto Baldanti, Thea Fischer, Ron Fouchier, and Catherine Moore
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Links for this episode * Correlate of protection needed for COVID-19 vaccines (Nat Med) * Simian adenoviruses as vaccine vectors (Future Viral) * Early SARS-CoV-2 spread in Lombardy (Nat Comm) * SARS-CoV-2 seroprevalence in Denmark (Clin Micro Inf) * SARS-CoV-2 testing in an academic center (Nat Biotech) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Brianne Barker
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Links for this episode
- Emergency drug use during a pandemic (Cell)
- Muscle-directed AAV capsids (Cell)
- Designer AAV muscles up (Cell)
- Letters read on TWiV 812
- Timestamps by Jolene. Thanks!
Weekly Picks
Dickson - Sid Caesar - The German General
Brianne - These Sea Slugs Break a Cardinal Rule of Animal Life
Rich - Seek by iNaturalist
Alan - The hard part of making a game is ... everything
Vincent - Columbia Pledges That All Future Campus Construction Will Be Fossil Free
Listener Picks
Bruce - Bat Superpowers
Gary - We’re Already Barreling Toward the Next Pandemic
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impact of Tocilizumab, and incidence of long COVID.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Data on Pfizer-BioNTech in 5-12 year olds (Pfizer) * Safety of additional vaccine dose (MMWR) * Oklahoma reinfection rates (OK DOH) * Regencov outcomes (NEJM) * Pfizer protease inhibitor trial (Pfizer) * WHO recommends antibody therapy (Hosp Health) * Tocilizumab use in hospitalized patients (Resp Care) * Long COVID (PLoS Medicine) * Letters read on TWiV 811 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * mRNA vaccines, a novel technology (Cell) * Proton gradient in giant virus (ISME J) * Tomograms of Pandoravirus massiliensis * Pandoraviruses are not alive (virology blog) * Letters read on TWiV 810 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – PhD Comics: Words Said By No Academic Ever
Kathy – Bach Cello Suite #1 visualization
Rich – Hypnagogia
Vincent – Landsat 9 and Wiki
Listener Picks Lori – Project Hail Mary by Andy Weir
Kevin – Oak Savannahs
Intro music is by Ronald Jenke
Send your virology questions and comments to twiv@microbe.tv
TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Amy Rosenfeld
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Links for this episode * SARS-CoV-2 like viruses from Laotian bats (Res Sq) * Herpesvirus in rabies endemic vampire bats (Nat Comm) * Letters read on TWiV 809 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – George Carlin: “Stuff”
Amy – The best of me by David Sedaris
Rich – You could have a secret twin (but not the way you think)
Alan – Nuclear powered Gameboy
Vincent – No, Vaccinated People Are Not ‘Just as Likely’ to Spread the Coronavirus as Unvaccinated People by Craig Spencer
Listener Picks Michael – The tangled history mRNA vaccines
Fernando – 1493 by Charles Mann
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remdesivir reduces risk of hospitalization, and anticoagulation regimens.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Pfizer phase III results in 5-11 year olds (Pfizer) * FDA authorizes booster (FDA) * V-safe vaccine pregnancy registry (CDC) * High antibody levels in cord blood (Am J Ob Gyn) * mRNA vaccines compared (MMWR) * Effectiveness of single shot J&J (medRxiv) * J&J booster results (J&J) * EUA expansion for Lilly mAbs (Lilly) * Remdesivir reduces hospitalization risk (Gilead) * DisCoVeRy on Remdesivir (Lancet) * Prophylactic anticoagulant dosing (Eur Heart J) * Letters read on TWiV 808 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vaccine distribution for global control of the pandemic.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Brianne Barker
Guests: Chadi Saad-Roy and Caroline Wagner
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Links for this episode * Vaccine nationalism and control of the pandemic (Science) * Vaccine sharing app * Dynamics of SARS-CoV-2 simulation * Dynamics of vaccination simulation * Vaccine effectiveness against hospitalization (MMWR) * Letters read on TWiV 807 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Ernie Kovaks-Nairobi Trio
Brianne – XKCD Summarizes this Episode
Rich – Texas Coronavirus Antibody REsponse Survey (CARES) (Dashboard)
Vincent – Elmer Pfefferkorn
Listener Picks Catherine – A Life on Our Planet
Attila – How to improve your chances of nudging the vaccine hesitant away from hesitancy and toward vaccinationIntro music is by Ronald Jenke
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Hospitalization pre- and post-vaccines (Res Sq) * Infection in children (medRxiv) * Updated mask guidance (CDC) * Transmission to masked and unmasked (MMWR) * Daily testing in schools (Lancet) * High barrier to mAb escape (bioRxiv) * Boosters not needed (Lancet) * Distribution system for mAbs (HHS) * Steroids in non-oxygen requiring patients (Int J Med) * Grants for long COVID (NIH) * Genomic surveillance in Africa (Science) * Letters read on TWiV 806 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the SARS-CoV-2 delta variant.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * ASV Vaccine Town Halls * Vaccine boosters not needed (Lancet) * Delta variant replication and immune evasion (Nature) * Epidemiologically linked COVID-19 outbreaks (MMWR) * Letters read on TWiV 805 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Sloan Foundation Theater
Kathy – COVID vaccines work, even if you don’t have side effects lay article primary article
Rich – Science Alone Can’t Heal a Sick Society by Jay S. Kaufman
Vincent – Sandra Black SciArt
Listener Pick Ruth – Radio Lento podcast
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Virus hunter Mya Breitbart joins TWiV to describe her laboratory’s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more.
Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier
Guest: Mya Breitbart
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Links for this episode * Viruses of spinybacked orbweavers (J Gen Virol) * Viruses of terrestrial arthropods (PeerJ) * Pepper mild mottle virus in sewage (PLoS Path) * Environmental DNA in marine community (Nat Comm) * Viral community of freshwater springs (mBio) * Phage puppet masters in the oceans (Nat Micro) * Letters read on TWiV 804 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Official-Droodles-Home
Alan – The 31st First Annual Ig Nobel Prize Ceremony video (and the text version)
Vincent – Biden’s federal and business vaccine mandates
Listener Pick Anonymous – The Ivermectin Episode – Behind the Bastards
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, antibodies in Kenyan blood donors, infections after vaccination, anticoagulation for thromboprophylaxis, baracitinib efficacy, long-term symptoms in adults, and sustained symptoms after severe disease.
Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!
Links for this episode * Overlooked shortcomings of observational studies (Op For Inf Dis) * Guidelines for clinical management (Op For Inf Dis) * ER visits and hospitalization among children (MMWR) * Hospitalization of adolescents (MMWR) * Seroprevalence in the US (JAMA) * Seroprevalence in Kenya (JAMA) * Infections after vaccine (medRxiv) * Israel data dashboard * Guidelines on anticoagulation for thromboprophylaxis (Blood Adv) * Baricitinib efficacy (Lancet) * Long term symptoms, US adults (MMWR) * Severe disease associated with long term symptoms (medRxiv) * Letters read on TWiV 803 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccination, the roles of T cells, and whether booster vaccinations are needed.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Shane Crotty
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Links for this episode * ASV Vaccine Town Halls * SARS-CoV-2 immune memory 8 months post-infection (Science) * SARS-CoV-2 T cell epitopes (Cell Host Microbe) * Letters read on TWiV 802 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – How the cat gets its stripes
Kathy – Kurzgesagt on Giruses (giant viruses) and beautiful APOD
Rich – The 1911 Triangle Factory Fire; Triangle: The Fire That Changed America by David Von Drehle
Vincent – Two Top F.D.A. Vaccine Regulators Are Set to Depart During a Crucial Period
Listener Picks Debby – River Runner
Lin – Your Vaccinated Immune System Is Ready for Breakthroughs
Intro music is by Ronald Je
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The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic human viruses were brought into Mexico during the transatlantic slave trade.
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * ASV Vaccine Town Halls * COVID-19 excess mortality (eLife) * Tracking pandemic death toll (eLife) * COVID-19 vaccines and delta variant (NEJM) * Slave trade carries viruses into Mexico (eLife) * Letters read on TWiV 801 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Victor Borge, Phonetic Punctuation
Brianne – Cat TV
Rich – Cochrane review: Ivermectin for preventing and treating COVID‐19
Alan – Cockpit video of flying into Oshkosh
Vincent – Medical News Network Morning Medical Update
Listener Pick Jody – Human Body Theatre and Plagues: The Microscopic Battlefield
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Do not take veterinary ivermectin (FDA) * Ivermectin side effects (CDC) * Do not use convalescent plasma (IDSA) * COVID-19 in pregnant women (JAMA) * Children and COVID-19 data (AAP) * Long COVID in 11-17 year olds (Res Square) * Delta outbreak elementary school (MMWR) * Validation of at-home antigen test (JAMA) * Shedding in infected vaccinated people (medRxiv) * Compared antibody responses after mRNA vaccination * (JAMA) * AZD7442 PROVENT phase III (AZ) * Fluvoxamine trial (medRxiv) * One-year outcomes hospital survivors (Lancet) * Post-vaccination illness (Lancet) * Letters read on TWiV 800 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Correlate of protection needed for COVID-19 vaccines (Nat Med) * Neutralizing antibodies predict protection against symptomatic COVID-19 (Nat Med) * Host and vector importance for Ross River virus (eLife) * Coronavirus in the U.S.: Latest Map and Case Count (NY Times) * Letters read on TWiV 799 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – A microscopic video shows the coronavirus on the rampage
Kathy – Sabin Oral Sundays in Cuyahoga County, 1962
Rich – The Continuing COVID-19 Pandemic: Current Issues and Glimpse Into the Future
Vincent – Demand Surges for Deworming Drug for Covid, Despite Scant Evidence It Works
Listener Picks Ronald – Immunity to COVID-19 could last longer than you’d think
Agnes – Space Shuttle Prints
Intro music is by Ronald Jenkees
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The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China.
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episode * Biden preliminary report on virus origins (NY Times) * Window on SARS-CoV-2 origins closing (Nature) * WHO Committee members on TWiV 760 * Origins of SARS-CoV-2 review (Cell) * Comirnaty? Really Pfizer? (FDA) * Why the weird name for Pfizer vaccine (Quartz) * US vaccine names (CDC) * More coronaviruses from rodents in China (J Viral) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – The Brilliant Abyss by Helen Scales
Kathy – Solar System ball drop
Rich – Dr. Fox effect
Alan – Patty Wagstaff virtual airshow cockpit video
Vincent – Office Hours
Listener Picks Karen – The Dog Will See You Now
Alicia – Bio-Rad GTCA Song
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * COVID-19 false dichotomies (BMC Inf Dis) * Virological characteristics of infections (medRxiv) * Transmission among close contacts (JAMA) * Comirnaty licensed (FDA) * Cost of hospitalization of unvaccinated (Health Sys Tracker) * 29 times higher hospitalization among unvaccinated (MMWR) * Third dose boosts antibody potency and breadth (medRxiv) * J&J second dose (J&J) * Letters read on TWiV 797 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Paul Bieniasz and Theodora Hatiziiouannou
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Links for this episode * High genetic barrier for SARS-CoV-2 antibody escape (bioRxiv) * Enhanced antibody one year after COVID-19 (Nature) * Letters read on TWiV 796 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – NIF and Photon Science: fusion reaction generates 1.3 MJ
Brianne – The PCR Song
Rich – 1) How Boston Dynamics’ Spot Robot Works! 2) Inside the lab: How does Atlas work?3) Atlas | Partners in Parkour
Theodora – Kevin Parry turning into random objects
Vincent – Lex Fridman
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Age and pediatric household transmission (JAMA) * Rapid antigen testing in remote communities (MMWR) * Shedding of infectious virus from vaccinated individuals (medRxiv) * Additional vaccine doses for immunocompromised (FDA) * New vaccine mandate for New York (NYS) * Vaccination suppresses variant emergence (medRxiv) * mRNA vaccine effectiveness in nursing homes (MMWR) * Effectiveness of mRNA vaccines against hospitalization (MMWR) * mRNA vaccine sustained effectiveness against hospitalization (MMWR) * No benefit of convalescent plasma for high-risk outpatients (NEJM) * Letters read on TWiV 795 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Vaccine Town Halls (ASV) * Arboviral illness, US, 2019 (MMWR) * Estimating SARS-CoV-2 infectiousness (Science) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Climate Reports | United Nations
Brianne – Astronomy Picture of the Day: A Perfect Spiral
Rich – COVID-19 false dichotomies
Alan – Fixing broken machines
Vincent – MKBHD Studio Tour 2021
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Vaccine effectiveness against transmission (Euro Surveill) * Effectiveness of daily antigen tests (medRxiv) * Interim guidance for fully vaccinated people (CDC) * Elapsed time since BNT162b2 vaccine and reinfection (medRxiv) * Reduced risk of infection after vaccination (MMWR) * Therapeutic anticoagulants in critically ill patients (NEJM) * 6 month outcomes in hospitalized patients (J Gen Int Med) * Letters read on TWiV 793 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Jeffrey Shaman
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Links for this episode * A guide to R (Nature) * Epidemiology of three SARS-CoV-2 VOC (medRxiv) * Impact of delta variant in India (medRxiv) * Letters read on TWiV 792 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Social Lives of Giraffes
Kathy – Saturn’s Iapetus, moon in 3-D
Vincent – Arkansas Governor Wants To Reverse A Law That Forbids Schools To Require Masks
Intro music is by Ronald Jenkees
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TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * SARS-CoV-2 in wild deer (bioRxiv) * Rapid T cell induction by mRNA vaccine (Nature) * T cell depleted macaques recover from SARS-CoV-2 infection (mBio) * Letters read on TWiV 791 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Virgin Hyperloop shows off the future
Brianne – BioNumbers
Rich – Advice will evolve as COVID situation changes
Alan – Mars Perseverance-themed geocaching swag
Vincent – Mattel’s Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls
Listener Picks Nancy – Vaccines at a Party
Jeff – How to Survive a Plague, Part 2
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by antibodies produced by infection or vaccination, longer hospital stays associated with remdesivir treatment, and post-acute sequelae of infection and impact on quality of life 1-6 months after illness.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Outbreak in Barnstable County, MA (MMWR) * Kinetics of delta variant infections (medRxiv) * Prophlaxis with Regeneron mAbs (Regeneron) * Subcutaneous mAbs to prevent COVID-19 (NEJM) * Variant neutralization by infection or vaccine antibodies (Clin Inf Dis) * Remdesivir associated with longer hospital stays (JAMA) * Post-acute sequelae (Op For Inf Dis) * Letters read on TWiV 790 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * NYC first to require vaccination proof (Reuters) * Leaked internal CDC document (WaPo) * Manuscripts on increased virulence (one, two, three) * Disease protection by non-neutralizing antibodies (Cell) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Nobel Prize Games
Kathy – Snail sensors
Rich – In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope by Rana Awdish
Vincent – The Provincetown Covid data is actually good news (if you are vaccinated) and I Was the Architect of Operation Warp Speed. I Have a Message for All Americans.
Listener Pick Jake – NASA spinoff
Peter – Bernard, the Extraordinary Moth
Intro music is by Ronald Jenkees
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Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous system.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Kiran Thakur
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Links for this episode * COVID-19 neuropathology (Brain) * Infections in vaccinated people (MMWR) * Infections in vaccinated people (NEJM) * Letters read on TWiV 788 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Simone Biles and Suni Lee
Brianne – How Speed and Distance Dictate the Way Olympians Run
Rich – CDC reversal on indoor masking prompts experts to ask, ‘Where’s the data?’
Vincent – Paul and the Mosquitos
Listener Pick Lin – Your Vaccinated Immune System is Ready For Breakthroughs
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody response after third vaccine dose in kidney transplant recipients, protection afforded by mRNA vaccines fully vaccinated people with and without prior infections, correlates of protection in nonhuman primates, lack of effectiveness of doxycycline, neurological manifestations of COVID-19, and infection in vaccinated health care workers.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Updated mask guidance (CDC) * Infections in public school district employees (MMWR) * 10% of positive kids need hospitalization (Houston Chronicle) * Effectiveness of vaccines vs delta variant (NEJM) * Antibody response after third vaccine dose (JAMA) * Severe COVID-19 in kidney transplant patients (Kidney Intl) * mRNA vaccine protection with or without prior infection (medRxiv) * Doxycycline ineffective (Lancet) * Neurological manifestations (Lancet) * Infections in vaccinated health care workers (NEJM) * Letters read on TWiV 787 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells from patients with severe COVID-19.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Off-season RSV in Australia (medRxiv) * Impaired innate immunity in severe COVID-19 (Cell) * Letters read on TWiV 786 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Science of Swimming
Kathy – Talking to the vaccine hesitant and covidactnow.org
Rich – The Disinformation Dozen | Center for Countering Digital Hate (CCDH on wiki)
Vincent – Russia discards Pirs docking port to clear way for new space station module (IG post)
Listener Pick April – Pemberton Aviation (Facebook, YouTube)
Intro music is by Ronald Jenkees
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In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Letters read on TWiV 785 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection disrupts intracellular calcium homeostasis. Live streamed during the 2021 annual meeting of the American Society for Virology.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Brianne Barker
Guests: Joseph Hyzer and Moriah Szpara
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Links for this episode * Diversity of HSV2 in neonates (mSphere) * Genome of HSV1 from multiple sites in one person (J Inf Dis) * Rotavirus disrupts calcium homeostasis (mBio) * Rotavirus protein activates calcium sensor (J Virol) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Inside of Mars is not like Earth
Brianne – AlphaFold
Rich – Tesla motors
Alan – Diving for antique beer
Vincent – Dolly Parton Tried. But Tennessee Is Squandering a Miracle
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak of delta variant, low dose mRNA vaccination generates durable T cell memory and antibodies, protective immunity in recovered patients, assessment of BinaxNOW, no effect of oral azithromycin, post-discharge symptoms in Nigeria, and therapeutics for low and middle income countries.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Long COVID in children (JAMA) * Outcomes after MIS-C (Pediatrics) * Guidance for school opening (Amer Acad Ped) * Infection in well traced delta outbreak (medRxiv) * Immune memory 8 months post-infection (Science) * Low dose mRNA vaccine enhances T cells (medRxiv) * Protection after infection (Lancet) * Assessment of BinaxNOW (Sci Rep) * Rapid POC antigen tests (Cochrane Rev) * Oral azithromycin ineffective (JAMA) * Post discharge symptoms in Nigeria (AJTMH) * Therapeutics for low and middle income countries (AJTMH) * Letters read on TWiV 783 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six months of the pandemic, and a monoclonal antibody that broadly neutralizes many different sarbecoviruses.
Hosts: Vincent Racaniello and Amy Rosenfeld
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Links for this episode * Immune responses after heterologous COVID-19 vaccine boost (Nat Med) * Undiagnosed SARS-CoV-2 infections in US (Sci Transl Med) * Broadly neutralizing sarbecovirus antibody (Nature) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women, and evidence that retroviruses infected cetaceans before and after they moved into the oceans.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episode * SARS-CoV-2 on dogs and cats (Viruses) * Maternal to neonatal transfer of SARS-CoV-2 antibodies (J Clin Investîmes) * Retroviral evolution in cetaceans and their ancestors (Plos Path( * Letters read on TWiV 781 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Current Map | U.S. Drought Monitor
Brianne – A comic strip about immune responses
Alan – Superliminal game
Vincent – Birds are dying in NJ
Listener Picks 2listening1 – Renewal
Em – Cognitive Surplus
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine EUA to include GBS, interim immunogenicity of Ad.26.CoV2.s, effectiveness of mRNA vaccines to prevent hospitalization, Bamlanivimab plus Etesevimab for mild or moderate disease, and a meta-analysis of ivermectin results.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * School and child care guidance (CDC) * Transmission in schools (CDC) * Accuracy of lateral flow diagnostics (Lancet) * GBS with Ad.26.CoV2.s vaccine (FDA) * Ad.26.CoV2.s interim immunogenicity (NEJM) * mRNA vaccine effectiveness to prevent hospitalization (medRxiv) * Bamlanivimab plus Etesevimab (NEJM) * Meta-analysis of ivermectin studies (Clin Inf Dis) * Letters read on TWiV 780 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial protein to form a virus-like capsid that specifically packages its encoding mRNA.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episode * mRNA vaccine boosts cross-variant neutralizing Ab (Science) * mRNA vaccine boosts variant B and T cell responses (Science) * Directed evolution of virus-like nucleocapsid (Science) * Letters read on TWiV 779 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Science of Chocolate Chip Cookies
Alan – Keeping Black students in STEM
Vincent – Antiviral Program for Pandemics
Listener Pick Mark – Curator on the Loose, Classic Airliners and Vintage Pop Culture, Flying Men, Flying Machines, Thai Flying Club
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease with mRNA vaccines, ivermectin to prevent hospitalization, IL-6 antagonists and mortality, and impact of vaccination on long COVID.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Efficacy of portable air cleaners (MMWR) * Ad26.COV2.S elicited neutralization of variants (bioRxiv) * Prevention of COVID-19 with mRNA vaccines (NEJM) * Ivermectin to prevent hospitalization (BMC Inf Dis) * IL-6 antagonists and mortality (JAMA) * Impact of vaccination on long COVID (Lancet) * Letters read on TWiV 778 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza virus antigenic variation leads to better fitness and replacement of previously circulating variants.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Ron Fouchier
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Links for this episode * Ron Fouchier on TWiV 177, 291, 557 * Mutations driving H5N1 airborne transmission in ferrets (Cell) * SARS-CoV and SARS-CoV-2 transmission among ferrets (Nat Comm) * Avian influenza virus transmission among seals (Cell Host Micr) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Science News Cycle
Kathy – mRNA Day Kariko & Weissman lectures and Q&A
Vincent – Just Planes
Intro music is by Ronald Jenkees
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TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in Florida.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episode * Animal sales from Wuhan markets before COVID-19 (Sci Rep) * Dengue control by Wolbachia-infected mosquitoes (NEJM) * Fatal dengue in Florida (NEJM) * Letters read on TWiV 776 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – You Know You’ve Worked Too Long in a Lab When…
Alan – Massachusetts vaccine lottery
Vincent – Coonhound paralysis
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of protection against asymptomatic and symptomatic infection, BNT162b2 in ChAdOx-1-S primed individuals, prior infection rescues B and T cell responses to variants after vaccination, effect of vaccination on household transmission, germinal responses induced by mRNA vaccines, phase 3 results of Novavax vaccine, and long COVID as our next national health disaster.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Worry about human behavior, not variants (NY Times) * Moderna and Pfizer vaccines vs delta variant * Depression among public health workers (MMWR) * Correlates of protection (medRxiv) * mRNA vaccine in AZ recipients (Lancet) * Prior infection rescues B and T cell responses to variants (Science) * Effect of vaccination on household transmission (NEJM) * mRNA vaccines induce germinal responses (Nature) * Novavax vaccine phase 3 results (NEJM) * EUA for tocilizumab (FDA) * Long COVID, next national health disaster (NEJM) * Letters read on TWiV 775 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of the outbreak.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guests: Kristian Andersen and Robert Garry
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Links for this episode * Andersen laboratory * Recovery of deleted deep sequencing data (bioRxiv) * Animal sales from Wuhan wet markets (Sci Rep) * Danielle Anderson on Wuhan Lab (Bloomberg) * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – STEVE over Copper Harbor, MI
Vincent – Human Behavior During the Pandemic Is More Important Than Any Covid Variant
Intro music is by Ronald Jenkees
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Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: Laurie Garrett
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Links for this episode * Lauriegarrett.com * The Coming Plague * Betrayal of Trust * Trump sabotaged coronavirus response (Foreign Policy) * ASV Vaccine Town Hall * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – A Pivotal Mosquito Experiment Could Not Have Gone Better
Kathy – Microbiology at the Movies
Vincent – When a Good Scientist Is the Wrong Source
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * COVID-19 and birthday parties (JAMA) * Vaccines in transplant patients (Ann Int Med) * Reinfection of recovered patients (Clin Inf Dis) * Azithromycin lack of efficacy (Rev Med Virol) * Bacterial and fungal infections in hospitalized patients (Op For Inf Dis) * mAb treatment of ambulatory patients (Op For Inf Dis) * Remdesivir reduction of mortality (Gilead) * Letters read on TWiV 772 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2.
Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld
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Links for this episode * ASV Vaccine Town Hall 2:05 * 100 million year old bornavirus infections (PNAS) * Bornaviruses across geological timescales (PNAS) * Bornaviruses previously on TWiV 303, 347, 548 * Novel bat SARS-CoV-2 related coronaviruses (Cell) * Letters read on TWiV 771 * Timestamps by Jolene. Thanks!
Weekly Picks Amy – A relic from the Jurassic era
Alan – World of Wonders, by Aimee Nezhukumatathil
Vincent – Tom Buck’s YouTube Channel
Listener Pick Victor – Vaccines: A measured response
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #67, Daniel Griffin reviews antibodies to the virus early in the US, serology testing of blood donations, MIS-C in children under 21, myocarditis in competitive athletes, ER visits for suspected suicide attempts, delta variant in Scotland, Novavax vaccine phase 3 results, vaccine coverage in pregnant women, early monoclonal administration reduces hospitalization and mortality, casirivimab and imdevimab recovery trial results, and CDC guidance on postacute sequelae.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Antiviral antibodies early in US outbreak (CID) * Serologic testing of US blood donations (CID) * The virus, what went wrong (PBS) * MIS-C in children (JAMA) * Myocarditis in competitive athletes (JAMA) * ER visits for suspected suicide (MMWR) * Delta variant in Scotland (Lancet) * Novavax phase 3 results (Novavax) * Vaccine coverage in pregnant women (MMWR) * Early mAb reduces hospitalization and mortality (CID) * Regen-Cov trial results (Regeneron) * Guidance on postacute sequelae (CDC) * Letters read on TWiV 770 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
On this episode of TWiV, Novavax COVID-19 vaccine demonstrates 90% overall efficacy, preventing an antigenically disruptive change during growth of influenza virus vaccine in chicken eggs, and MIS-C is driven by loss of the gut mucosal barrier.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
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Download TWiV 769 (68 MB .mp3, 114 min)
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Links for this episode * ASV Vaccine Town Hall 2:05 * Novavax vaccine efficacy reported (Novavax) * H3N2 glycosylation in eggs (TWiV 480) * Preventing antigenically disruptive HA change in eggs (Cell Host Micr) * MIS-C due to leaky gut (J Clin Invest) * Letters read on TWiV 769 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Pandemics for Babies, Germ Theory for Babies, and Vaccines for Babies
Kathy – Playing with Time
Vincent – A Top Virologist in China, at Center of a Pandemic Storm, Speaks Out
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episode * ASV Vaccine Town Hall * Spread of SARS-CoV-2 variant in summer 2020 (Nature) * Nanobodies neutralize SARS-CoV-2 variants (Nature) * Letters read on TWiV 768 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Hotel Magdalena
Brianne – Antibody Song by Raven the Science Maven
Alan – How to play Magic: the Gathering
Vincent – Steve Gibson’s rant on Security Now
Listener Pick David – Coronavirus set to mu
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #66, Daniel Griffin covers treatment guidelines from IDSA, hospitalization of adolescents, estimating epidemiological dynamics from viral load distributions, incidence of infection according to baseline antibody status, assessment of reinfection in Italy, need for vaccination in previously infected individuals, assessment of protection against reinfection, antimicrobial use in hospitalized patients, effect of single dose ivermectin, and a trial of aspirin in hospitalized patients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * COVID-19 treatment guidelines (IDSA) * Hospitalization of adolescents (MMWR) * Estimating dynamics from viral load (Science) * Incidence according to antibody status (Lancet) * Reinfections in Italy (JAMA) * Need for vaccination in previously infected (medRxiv) * Assessment of protection against reinfection (ACC) * Antimicrobial use in hospitalized patients (Lancet) * Effect of single dose ivermectin (Viruses) * Aspirin in hospitalized patients (medRxiv) * Letters read on TWiV 767 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
David joins TWiV to relate how his near-death experience with Castleman’s disease motivated him to found the Center for Cytokine Storm Treatment & Laboratory and the CORONA project to identify and track all treatments reported for COVID-19 in an open-source data repository.
Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker
Guest: David Fajgenbaum
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Links for this episode * CORONA project * Center for Cytokine Storm Treatment & Laboratory * Castleman Disease Collaborative Network * Chasing My Cure * Letters read on TWiV 766 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – How Giraffes Beat High Blood Pressure
Kathy – Orangutan optical illusion
Vincent – Two quotes from Chasing My Cure by David Fajgenbaum
John Paul II: Dear young people, whether you are believers or not, accept the call to be virtuous. This means being strong within, having a big heart, being rich in the highest sentiments, bold in the truth, courageous in freedom, constant in responsibility, generous in love, invincible in hope.
David: Never stop questioning and always follow the data.
Intro music is by Ronald Jenkees
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TWiV reviews the new nomenclature for SARS-CoV-2 variants, effectiveness of Pfizer/BioNTech vaccine against variants, modified Moderna vaccine against variants, impact of COVID-19 interventions on influenza in China and the US, and binding of RaTG13 spike protein to ACE2 of multiple species.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Updated nomenclature of SARS-CoV-2 variants (WHO) * Pfizer-BioNTech vaccine effective against alpha variants (Lancet) * Novavax vaccine effective against beta variants (NEJM) * Moderna updated vaccine against beta and gamma variants (medRxiv) * Impact of COVID-19 interventions against influenza (Nat Comm) * RaTG13 spike binding to various ACE2 proteins (Cell) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – NASA’s Juno to Get a Close Look at Jupiter’s Moon Ganymede
Brianne – Send in the Bugs. The Michelangelos Need Cleaning.
Rich – All landers and rovers on Mars animated in video with human scale
Alan – Weird case cluster reported in MMWR 40 years ago; update on disease
Vincent – Virus isolates, strains, variants – what are they?
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #65, Daniel Griffin summarizes effects of non-pharmaceutical interventions, updated summer camp guidance from CDC, serology testing not recommended by FDA, antigen tests during a music event, inhibition of vaccine immunogenicity by methotrexate, phase 3 trial results for colchicine, and small airway disease as a post-acute sequelae.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Effects of vaccines and NPIs (JAMA) * Guidance on summer camps (CDC) * Antibody testing not recommended (FDA) * Antigen testing at a music event (Lancet) * Methotrexate and vaccine immunogenicity (Ann Rheum Dis) * Colchicine phase 3 results (Lancet Resp Med) * Small airway disease a post-acute sequelae (medRxiv) * Letters read on TWiV 764 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains how cap-snatching, the priming of viral mRNA synthesis with fragments of host mRNAs, can lead to the synthesis of novel viral proteins.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode * Cap-snatching makes new ORFs (Cell) * Cap-snatching leads to novel proteins (Cell) * Letters read on TWiV 763 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – Flat pasta that turns into shapes here and here
Rich – Ad Fontes Media Bias Chart (wiki)
Vincent – Martin Beck police mysteries
Listener Picks Greg – Stewart Lee on Loch Ness monster
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Robert Garry joins TWiV to explain how the molecular biology of SARS-CoV-2 shows that it came from Nature and not a lab, including the receptor binding domain, the furin cleavage site, and the two lineages circulating in Wuhan wildlife markets.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Robert Garry
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Links for this episode * The proximal origin of SARS-CoV-2 (Nature) * Two early genome lineages in Wuhan markets (virological.org) * Insights from spike proteins of bat sarbecoviruses (virological.org) * Letters read on TWiV 762 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – 143 Optical Illusions and Visual Phenomena
Brianne – The Arcane Research that Prepared Us for COVID-19
Rich – Hidden Brain podcast
Alan – A scientific theory of gist communication
Vincent – Divisive COVID ‘lab leak’ debate prompts dire warnings from researchers
Listener Picks Jon – Moderna Science Day
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #64, Daniel Griffin covers new guidance from NY on day camps, mitigation and infection rates in schools, testing to sustain in person instruction, Moderna mRNA vaccine highly effective in adolescents, longer storage of Pfizer vaccine, FDA EUA for sotrovimab, and persistent illness in UK children. Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Guidance on child camps and day care (NY State) * Mitigation and schools (medRxiv) * Masks in elementary schools (MMWR) * Testing to sustain in person instruction (MMWR) * TeenCOVE results (Moderna) * Pfizer/BioNTech vaccine handling and storage (CDC) * EUA for sotrovimab (FDA) * Illness duration in UK schoolchildren (medRxiv) * Letters read on TWiV 761 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans, members of the WHO team investigating the origins of SARS-CoV-2 join TWiV to explain the work done by the committee during phase one, their conclusions, and the extent of work that remains to be done in phase two.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Peter Daszak, Thea Kølsen Fischer, and Marion Koopmans
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Links for this episode * Peter on TWiV 615, 623 * Thea on TWiV 576 * Marion on TWiV 413, 548 * WHO report on origins of SARS-CoV-2 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – My Octopus Teacher
Rich – John Wyndam classic Sci Fi: The Chrysalids, The Day of the Triffids
Vincent – SARS-CoV-2 Phylogeny and Spatiotemporal Spread (paper)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
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Links for this episode * ASV vaccine town halls 15:10 * Porcine deltacoronavirus in Haitian children (medRxiv) * Canine coronavirus from Malaysian pneumonia patient (Clin Inf Dis) * No shift, measles (TWiV 340) * The Cancer Thief (TWiV * Letters read on TWiV 759 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Ants: workers of the world
Amy – Let The Record Show by Sarah Schulman
Rich – QAnon resembles the games I design
Alan – Librivox
Vincent – Stratechery
Listener Picks Fernando – The 60-year old scientific screwup that helped COVID kill
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody generation with extended interval of mRNA vaccination, no benefit of convalescent plasma in hospitalized patients, and risk of clinical sequelae after acute infection.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * COVID-19 in child care facilities (MMWR) * mRNA vaccine effectiveness (MMWR) * Excelsior pass (NYS) * Risk of SARS-CoV-2 reinfection in university students (CID) * Enhanced antibody production with longer mRNA vaccine interval (medRxiv) * Convalescent plasma trial in hospitalized patients (Lancet) * Phase 3 data on REGEN-COV (PR Newswire) * Clinical sequelae after acute COVID-19 (BMJ) * Letters read on TWiV 758 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * ASV vaccine town halls * 2% of SARS-CoV-2 positives carry most viral RNA (PNAS) * Pan-coronavirus nanoparticle vaccine (Nature) * Why HIV-1 particles have few spikes (PLoS Path) * Letters read on TWiV 757 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Darwin’s Arch Collapses
Kathy – The woman who discovered the first coronavirus
Rich – “Richard Feynman: The pleasure of finding things out”
Vincent – CORONA Project
Listener Picks JH – Fungus kills cicadas
Alan – Liftoff by Eric Berger
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and testing of a genetically stable version of the attenuated type 2 Sabin poliovirus vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
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Links for this episode * ASV vaccine town halls 3:16 * First smallpox vaccine day * Revised masking and distancing (CDC) * Science vs Spin (Sandman) * Artifactual SARS-CoV-2 integration (PNAS) * SARS-CoV-2 integration is artifactual (J Virol) * Engineering new OPV2 (Cell Host Micr) * Safety and immunogenicity of nOPV2 (Lancet) * Poliopolis (Lancet) * Letters read on TWiV 756 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Five Deeps
Amy – Premonition by Michael Lewis
Alan – The Secret Life of Groceries by Benjamin Lorr
Rich – The Way Ferrofluid Floats Above a Superconductor Is Unreal
Vincent – Threading the NEIDL
Listener Picks Iradis – SN15 Launch and Landing
Blue Pilgrim – Howland Garden Tools
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormycosis, and hydroxychloroquine treatment associated with increased mortality.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Moderna vaccine safe, effective in teens (AAP news) * Review of outdoor transmission (JID) * Pfizer/BioNTech vaccine EUA 12-15 year olds (FDA) * NSAIDS safe in COVID-19 (Lancet Rheum) * Post-COVID black fungus (Laryngol Otol) * HCQ and increased mortality (Nat Comm) * Letters read on TWiV 755 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * ASV vaccine town halls * Michelson Prizes * FDA authorizes Pfizer/BioNTech mRNA vaccine for adolescents (FDA) * TLR2 senses SARS-CoV-2 E protein (Nat Imm) * Review on CoV E protein (Virology J) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Lab.Hacks Lab Assistant App
Rich – Weird viral DNA spills secrets to biologists; COVAX
Kathy – Planet Earth Now
Vincent – Variants at ViralZone
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their relevance for eradication of poliomyelitis.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * ASV vaccine town halls * Sputnik Light * Ferret airborne transmission of influenza virus (Nat Comm) * Facility releases of poliovirus (Emerg Inf Dis) * Polio eradication progress (Polio Erad Init) * Letters read on TWiV 753 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Exotic mantis
Brianne – Types of Scientific Paper
Alan – Rusty Lake Games / Cube Escape Collection
Rich – The Departed Could Soon Become Compost in Colorado; Recompose (wiki)
Vincent – Public Health Image Library
Listener Pick Ivan – Apollo 11: As They Shot It
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation of rapid antigen tests, children making up a growing share of new cases, antibody response to mRNA vaccine in solid organ transplant recipients, and outcomes in hospitalized patients treated with tocilizumab.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Modeling future COVID-19 cases (MMWR) * Performance of rapid antigen tests (Ann Int Med) * Children are growing share of infections (AAP News) * Tocilizumab in hospitalized patients (Lancet) * Letters read on TWiV 752 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode * ASV vaccine town halls * Brazil rejects Gamaleya vaccine (Sci Transl Med) * Russian vaccine behavior (Sci Transl Med) * Is Gamaleya vaccine safe? (Science) * Furin cleavage site in replication and transmission (Nat Micro) * Furin site loss attenuates pathogenesis (Nature) * Timestamps by Jolene. Thanks!
Weekly Picks Rich – The diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project
Kathy – ISS, Crew Dragon, and the sun Doubly warped world of binary black holes
Vincent – Mr. Labman
Listener Picks Joy – Abandoned America: Matthew Christopher’s Autopsy of the American Dream
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Vaccine education town halls (ASV) * RSV cpDVG may influence clinical outcome (Nat Micro) * Henipa- and filo-like viruses in Trinidad bats (J Inf Dis) * Nice image of cpDVG generation * Letters read on TWiV 750 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Olympus Image of the Year Award
Alan – We need to improve the welfare of life science trainees
Rich – Sheldrick Wildlife Trust; The Reteti Elephant Sanctuary
Kathy – Aria Code Nessun dorma podcast
Vincent – Covariants
Listener Picks Justin – How Pfizer Makes Its Covid-19 Vaccine
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Summer camp guidance (CDC) * Protect yourself when fully vaccinated (CDC) * Updated recommendation on J&J vaccine (MMWR) * NY variant B1.526 (one, two) * Declining global CFR (AJTMH) * Protease inhibitor in phase I (Pfizer) * Molnupiravir advances (Merck) * Post acute sequelae (Nature) * Letters read on TWiV 749 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-19 patients and vaccine recipients.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episode * In-host SARS-CoV-2 evolution drive by antibody (PLoS Path) * COVID-19 and CVT (OSF) * CoronaVac underperforms (Economist) * Precision Vaccines Program postdoc position * Letters read on TWiV 748 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Show Your Immune System Some Love
Alan – Cyborg sea turtle
Vincent – Thomas Brock dies
Listener Picks April – The High Line
Michel – Why you can’t compare Covid-19 vaccines
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxNow rapid in-home antigen test, postvaccination infections in a nursing facility, safety of mRNA vaccine in pregnant women, case control study of Bamlanivimab, no evidence for brain infection in patients with neurolgical symptoms, and mortality among US patients hospitalized with COVID-19.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Healthcare worker survey (KFF) * Seropositivity and infection risk in young adults (Lancet) * Efficiency of double masking (JAMA) * BinaxNow antigen test (Abbott) * mRNA vaccine safety in pregnant persons (NEJM) * Bamlanivimab case control study (CID) * COVID-19 neuropathology (Brain) * Mortality among hospitalized COVID-19 patients (JAMA) * Letters read on TWiV 747 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes towards public communication.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episode * Viral brain entry by transcytosis across endothelial cells (mBio) * Scientists attitudes towards public communication (PNAS) * Letters read on TWiV 746 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – NASA ingenuity helicopter ride
Brianne – Vaccine Efficacy Animation
Kathy – Airglow over the Azores
Vincent – Gisaid
Intro music is by Ronald Jenkees
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Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
Guest: Nadine Lamberski
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Links for this episode * Gorillas receive COVID-19 vaccine (Nat Geo) * COVID-19 vaccine for great apes and mink (Zoetis) * Letters read on TWiV 745 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Dream Vaccine
Alan – Taking vaccines to Smith Island
Kathy – Daily Overviews Subscribe Tulips
Vincent – Nextstrain
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Healthcare worker deaths (Guardian) * Children and adolescent disease severity (JAMA) * Physical inactivity and increased disease risk (BMJ) * Expansion of Pfizer/BioNTech EUA (pdf) * Thrombosis after ChAdOX1 vaccine (NEJM) * Your guide to masks (CDC) * Phase 3 mAb prevention trial (Regeneron) * Letters read on TWiV 744 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld
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Links for this episode * Pleomorphic virus particles and cell entry (Nat Micro) * Letters read on TWiV 743 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – A tiny particle’s wobble could upend the laws of physics
Rich – COVID-19/SARS-CoV-2: Viruses, Vaccines & Variants Made Easy
Amy – Vaccine Anthems
Vincent – DarkNet Diaries Ep. 86
Listener Picks Steve – Cover Your Freakin’ Face
Intro music is by Ronald Jenkees
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TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * TMEM16 inhibitors block SARS-CoV-2 driven syncytium formation (Nature) * Letters read on TWiV 742 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – COVID-19: a disaster five years in the making
Alan – The Tyranny of Merit
Rich – Racism Makes Me Question Everything. I Got the Vaccine Anyway
Kathy – The Transcontinental Burrito Tunnel
Vincent – Trudy Rey’s YouTube Channel
Listener Picks Jeff – Rebecca Lee Smith on Left Right and Center
Ryan – Perfect Strangers (clip)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and blood clots, and long COVID and the effect of vaccines.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Children with MIS-C (JAMA) * Transmission with masks (Op For Inf Dis) * Accuracy of diagnostic tests (J Clin Micro) * Long COVID in hospitalized patients (BMJ) * Neurological and psychiatric outcomes of COVID-19 (medRxiv) * Letters read on TWiV 741 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619 base changes was rescued by genomes with very large internal deletions.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * NIDO 2021 Symposium * ASV hosts free COVID-19 Vaccine Education Town Halls (register here) * Research position in Spindler laboratory * Attenuation of poliovirus by codon deoptimization (Science) * Rescue of codon-deoptimized RSV by large deletions (PNAS) * Letters read on TWiV 740 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Let us now praise tiny ants
Brianne – Small-school science
Rich – Smallpox ‘virus squads’ and the mandatory vaccinations upheld by the Supreme Court
Kathy – The Transcontinental Burrito Tunnel
Vincent – Glass music by Robert Tiso
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Guest: Arturo Casadevall
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Links for this episode * Victory for Scientific Pragmatism (New Atlantis) * Convalescent plasma levels and risk of COVID-19 death (NEJM) * COVID-19 convalescent plasma safety indicators (JCI) * COVID-19 convalescent plasma reduces mortality (medRxiv) * Pfizer mRNA vaccine in 12-15 year olds (Pfizer) * NIDO 2021 Symposium * ASV hosts free COVID-19 Vaccine Education Town Halls (register here) * Letters read on TWiV 739 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – The Ocean’s Youngest Monsters Are Ready for Glamour Shots
Alan – 7 Billion Humans
Rich – 15 Fascinating Animal X-Rays From the Oregon Zoo
Vincent – Respiratory pathogen trends
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Pfizer mRNA vaccine is 100% effective in 12-15 year olds (Pfizer) * Cue at-home PCR test receives FDA EUA (Cue) * DxTerity COVID-19 saliva nucleic acid at-home test (Amazon) * T-Detect T cell test (T-Detect) * GSK submits EUA for VIR-7831 (GSK) * Letters read on TWiV 738 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of the genome throughout the pandemic and detection of genome mutations from variants of concern.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: John Dennehy, Davida Smyth, and Monica Trujillo
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Links for this episode * Protocol for detecting SARS-CoV-2 RNA in wastewater (medRxiv) * Mutations from VOC in NYC wastewater (medRxiv) * WHO report on COVID-19 origins (pdf) * Effectiveness of mRNA vaccines at preventing SARS-CoV-2 infection (MMWR) * Prothrombic thrombocytopenic disorder after AZ vaccine (Res Square) * NIDO 2021 Symposium 1:12:02 * Postdoctoral position at Towson University 1:15:08 * ASV hosts free COVID-19 Vaccine Education Town Halls (register here) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – 250,000 Dominoes
Brianne – Using RT-PCR in COVID-19 Testing
Rich – Beaded Lacewings Can Take Down Six Termites With A Single Fart
Kathy – Tracking the COVID code
Vincent – Administering vaccines to adults
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Alessandro Sette
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Links for this episode * Little impact of SARS-CoV-2 variants on T cell reactivity (bioRxiv) * NIDO 2021 Symposium * Postdoctoral position at Towson University * ASV hosts free COVID-19 Vaccine Education Town Halls (register here) * Letters read on TWiV 736 * Timestamps by Jolene. Thanks!
Weekly Picks Alan – The Disinformation Dozen report
Rich – No needle, but the damage was done
Kathy – Zinn art David Zinn
Vincent – Clueless Wall Street Journal Op-Ed Endorses PACE as “Prevailing View” Among Docs
Listener Picks Justin – Finnish astrophotographer spends 12 years creating a Milky Way mosaic
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on asymptomatic infections, vaccine safety in PASC patients, and early use of aspirin associated with decreased mortality.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * COVID-19 in primary and secondary schools (MMWR) * Low transmission in elementary schools (MMWR) * COVID-19 testing guidance (CDC) * COVID-19 vaccines and asymptomatic infections (Clin Inf Dis) * Vaccine safety in long COVID (medRxiv) * Phase 3 results of antibody cocktail (Regeneron) * Aspirin associated with decreased mortality (Anesth Analg) * Post-acute long COVID-19 syndrome (Nat Med) * Timing, duration, health impact of PASC (medRxiv) * Persistent neurologic and cognitive dysfunction in PASC (Ann Clin Trans Neurol) * Letters read on TWiV 735 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of innate immune responses during infection.
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Brianne Barker, and Amy Rosenfeld
Guest: Susan Weiss
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Links for this episode * CoV pathogenesis in CNS (J Neuro Pharm) * SARS-CoV-2 induces dsRNA-mediated innate responses (bioRxiv) * Screen of FDA-approved drugs (J Viral) * Letters read on TWiV 735 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Tiktok of How mRNA Vaccines Work
Alan – Dark
Rich – Unmixing Color Machine (Ultra Laminar Reversible Flow) – Smarter Every Day 217
Amy – MOMA Calder exhibit, reviewed in NYTimes
Vincent – Ripple Training (free YouTube channel)
Listener Picks Ruth – 100 million year old seafloor bacteria resuscitated
Iradis – Linda Zall, CIA spy for science
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, alleviation of COVID-19 symptoms after vaccination, vaccine trials in children, and IDSA approval of a mAb cocktail.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Effectiveness of 3 ft vs 6 ft (CID) * Effect of physical distancing, masks, eye protection (Lancet) * Vaccine second dose completion (MMWR) * IDSA mAb recommendations (IDSA) * Letters read on TWiV 733 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nucleic acid analysis.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Forest on TWiV 391 * Swabbing surfaces in San Diego (10News) * Nido21 meeting * Molnupiravir in phase 2a (Fierce Biotech) * Letters read on TWiV 732 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – 10 amazing science tricks with liquids
Brianne – How Do Blind Worms See the Color Blue?
Rich – Statewide Study Shows Evidence Of Significant COVID-19 Antibodies In Children
Kathy – Dark side of the moon as it crosses Earth
Vincent – Wasdkeyboards and Novelkeys
Listener Pick Bronwen – COVID Performance Index
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK.
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Brianne Barker
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Links for this episode * Ebolavirus disease outbreak continues in Africa (ProMedMail) * List of Ebolavirus outbreaks (Wikipedia) * Ebolavirus genome sequences from Guinea (virological) * Bias in reporting on childhood SARS-CoV-2 infections (Clinical Inf Dis) * Estimated SARS-CoV-2 prevalence <18 years (MMWR) * Estimated burden of SARS-CoV-2 by age group (CDC) * UK long COVID estimates (pdf) * Space Shuttle fly-by Vincent’s office (YouTube) * Letters read on TWiV 731 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Who Would Kidnap a Space Telescope?
Alan – Radio Garden
Rich – Countries with more obesity have had more covid deaths on average
Vincent – Concord Aerospace
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies, preliminary findings on an oral antiviral, clinical trial of ivermectin, and recommendations for upcoming gatherings.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * SARS-CoV-2 seroprevalence in <18 year olds (MMWR) * EUA for T cell test (FDA) * Lilly mAb phase 3 results (Lilly) * VIR-7831 mAb phase 3 results (Globenewswire) * Molnupiravir phase 2a results (Merck) * Ivermectin not supported for mild COVID-19 (JAMA) * Recommendations for fully vaccinated people (CDC) * Letters read on TWiV 730 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Matt Frieman
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Links for this episode * Phase 1-2 trial of Novavax protein vaccine (NEJM) * MERS-CoV spike nanoparticle vaccine in mice (Vaccine) * Novavax phase 3 press release * When you’ve been fully vaccinated (CDC) * Letters read on TWiV 729 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Covid-19 deaths per million ranked by average income
Brianne – KFF COVID-19 Vaccine Monitor for Feb 2021 and KFF COVID-19 Vaccine Monitor Dashboard
Rich – The Woman Who Stood Between America and a Generation of ‘Thalidomide Babies’(wiki)
Kathy – Quadrantid meteor (Quadrantids)
Vincent – Higher Superstition by Paul Gross and Norman Levitt
Intro music is by Ronald Jenkees
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TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Mavis Agbandje-McKenna dies (UF) * Mavis on TWiV 448 * Maximizing mask fit (MMWR) * Genomic and subgenomic RNA in COVID-19 patients (medRxiv) * Effect of spike changes on protection of mice (mBio) * Letters read on TWiV 728 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Wild animal photos
Brianne – Greater than COVID
Alan – WHO report on infodemic response
Rich – Reference Guide to the International Space Station
Vincent – 3D Molecular Designs
Listener Picks Lisbeth – Have the new jab
Karen – Cholera exhibit at Museum of Trades and Crafts
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent plasma trial, dexamethasone in hospitalized patients, data on tocilizumab, and long COVID in children.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * SARS-CoV-2 attack rates in children and adults (Clin Inf Dis) * Documents for J&J COVID-19 vaccine review (FDA) * Convalescent plasma and clinical outcomes (JAMA) * NIH halts convalescent plasma trial (NIH) * Dexamethasone in hospitalized COVID-19 patients (NEJM) * Tocilizumab in hospitalized COVID-19 patients (NEJM) * Update on long COVID prevalence (UK ONS) * Letters read on TWiV 727 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV-2 entry into cells.
Hosts: Vincent Racaniello, Rich Condit, Brianne Barker and Kathy Spindler
Guest: Janet Iwasa
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Links for this episode * The Animation Lab * SARS-CoV-2 animation * Documents for J&J COVID-19 vaccine review (FDA) + Phase III data (pdf) + Slide presentation of data (pdf) + Addendum (pdf) + Summary of v-Safe data (pdf) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – How T cells see SARS-CoV2
Rich – Ice bubbles in Lago Bianco, Switzerland
Kathy – Music in COVID-19 control tents
Vincent – Perseverance runs on processors used in 1990s iMacs
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Eva Harris and Janet Smith
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Links for this episode * Eva Harris on TWiV 228 * Zika virus in Nicaragua (virology blog) * How an antibody block NS1-mediated endothelial dysfunction (Science) * Broadly protective antibody against NS1 (Science) * Letters read on TWiV 725 * Timestamps by Jolene. Thanks!
Weekly Picks Alan – Science Photographer of the Year Awards
Rich – Bar Keeper’s Friend
Kathy – Perseverance secret message and other Easter eggs, 11 million Earthlings’ names, “Name the Rover” essay contest. Sign up to send your name on a future Mars mission.
Vincent – COVID-19 dataset
Listener Picks Matthew - Remembering the colleagues we lost to COVID-19
Lori - Iceberger
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect of vitamin D and remdesivir in clinical studies, and a long COVID research initiative from NIH.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Updated NYC mask guidance (NYC Health) * Two masks recommended (CDC) * Effectiveness of testing in nursing homes (Clin Inf Dis) * Vaccine reactogenicity and antibody response after COVID-19 (medRxiv) * Bamlanivimab alone or with Etesevimab (JAMA) * Non-steroidal anti-inflammatory drugs and death (BMJ) * Budesonide and COVID-19 (medRxiv) * No effect of vitamin D high dose (JAMA) * Remdesivir little effect on hospitalized patients (NEJM) * Sequelae 6 months after infection (JAMA) * Long COVID initiative (NIH) * Letters read on TWiV 724 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guest: Ginger Campbell, MD
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Links for this episode * Brain Science Podcast * Dr. Campbell’s video on palliative care (YouTube) * Resources on palliative care (WHO) * Interviews with Paul Offit (one, two) * Being Mortal by Atul Gawande * Letters read on TWiV 723 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Soapbox Gallery
Brianne – Cell Picture Show
Rich – Perseverance Rover’s Descent and Touchdown on Mars (Official NASA Video)
Vincent – Our World in Data (see COVID-19 vaccinations)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration of mRNA vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Resurgence of COVID-19 in Manaus (Lancet) * SARS-CoV-2 related viruses in Southeast Asian bats (Nat Comm) * Increased Ct following COVID-19 vaccination (medRxiv) * Letters read on TWiV 722 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – What is the polar vortex?
Brianne – Cloning of the black-footed ferret
Alan – Explaining mRNA vaccines with Star Wars
Rich – Brighton Collaboration (BRAVATO); Ad26 vector template
Kathy – Target public health ads to zipcodes
Vincent – And Then the Gorillas Started Coughing
Listener Pick Kim – Virus getting the shot (jpg)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc plus vitamin C, anticoagulation therapy effect on mortality, and multi system inflammatory phase in children.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Guidance on school openings (CDC) * Calcifediol Treatment and COVID-19 (Lancet preprints) * Zinc and vitamin C for COVID-19 (JAMA) * Early anticoagulant therapy (BMJ) * Multisystem inflammatory phase in children (CDC) * Letters read on TWiV 721 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a licensed vaccine, sterilizing immunity, herd immunity, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Paul Offit
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Links for this episode * Vaccine education center * Letters read on TWiV 720 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Life in a Day 2020
Brianne – Microcosms in Glass
Alan – NEJM article on promoting vaccination, interview with lead author
Rich – The Microbescope
Vincent – Autism’s False Prophets by Paul Offit
Listener Pick Earl – Science is Real Pins
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral load, EUA for bamlanivimab and etesevimab administered together, and preliminary results of Tocilizumab in hospitalized patients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Resurgence of COVID-19 in Brazil (Lancet) * Pfizer vaccine reduces viral load (medRxiv) * EUA for bamlanivimab plus etesevimab (pdf) * Tocilizumab in hospitalized patients (medRxiv) * Bacterial superinfections in COVID-19 (Open For Inf Dis) * Letters read on TWiV 719 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading exonuclease.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * AZD1222 single dose efficacy and booster timing (Lancet preprint) * Safety and efficacy of Sputnik V vaccine (Lancet) * Proofreading exonuclease regulates CoV recombination (PLoS Path) * Letters read on TWiV 718 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Do scientists read enough fiction?
Rich – Insects in flight; Insect flight|Capturing takeoff
Kathy – Badger seal
Vincent – MicrobeTV merchandise
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the emergence of variants with increased resistance to neutralization.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guests: Paul Bieniasz and Theodora Hatziioannou
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Links for this episode * Evolution of antibody immunity to SARS-CoV-2 (bioRxiv) * mRNA vaccine elicited antibody to variants (bioRxiv) * Escape from neutralizing antibodies by SARS-CoV-2 variants (eLife) * Musings of an anonymous, pissed off virologist (virology blog) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Mars Perseverance Rover
Alan – The Outlaw Ocean
Rich – Anand Varma Photography
Vincent – Virology Lectures 2021
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenicity after a single vaccine dose in seropositive individuals, single dose vaccination in seropositive health care workers, and results of three clinical trials on the use of anticoagulants.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Resistance of variants to mAb neutralization (bioRxiv) * Safety and efficacy of Sputnik V (Lancet) * Increased vaccine reactogenicity in seropositives (medRxiv) * Single dose vaccination in seropositive health care workers (medRxiv) * Update on vaccine intervals (CDC) * Single dose AZD1222 results (Lancet preprints) * Three RCT on anticoagulants (NIH) * Letters read on TWiV 716 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * TMPRSS2 is why hydroxychloroquine failed (PLoS Path) * Safety and efficacy of BNT162b2 mRNA vaccine (NEJM) * Letters read on TWiV 715 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – How the Body Reacts to Viruses
Rich – How do wombats poop cubes?
Kathy – The Verse by the Side of the Road
Vincent – Janet Iwasa’s SARS-CoV-2 entry animation
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
Guest: Jason McLellan
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Links for this episode * Prefusion spike structure (Science) * Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer * Novavax COVID-19 vaccine phase 3 results (Novavax) * J&J COVID-19 vaccine phase 3 results (J&J) * B.1.1.7 has been in the US since November 2019 (virological.org) * NERVTAG report on B.1.1.7 virulence (pdf) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Pandemic Pivot and Tuba Skinny
Alan – Technological challenges in vaccine rollout
Rich – I was lucky to find this vaccine anywhere
Vincent – Lady Gaga’s MIXED METER Star Spangled Banner?!
Intro music is by Ronald Jenkees
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In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody therapy, and a study of colchicine for treatment of disease.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Novavax vaccine phase 3 results (Novavax) * J&J vaccine phase 3 results (J&J) * COVID-19 and transmission in K-12 schools (MMWR) * Lilly mAb therapy (NEJM) * Regeneron mAb prophylaxis (Regeneron) * Colchicine for COVID-19 (Cardiol Today) * Letters read on TWiV 713 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Gisa Gerold, Stefanie Becker, and César Muñoz-Fontela
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Links for this episode * German Society for Virology * Ticks in Germany and TBEV (Sci Rep) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Biden’s COVID-19 strategy (pdf) * CDC evaluation of BinaxNOW antigen test (MMWR) * FDA instructions for BinaxNOW test (pdf) * Adam Neely on Sea Shanties (YouTube) * Letters read on TWiV 711 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Spelling Bee
Brianne – He Made a Viral Bernie Meme Site. Now He Has to Keep it Going
Alan – America’s Cup AC75 capsize and aftermath in qualifying race
Rich – Game Theory’s UNCENSORED Interview With Dr. Fauci | The Truth About COVID-19 Vaccines
Vincent – Top Science Podcasts
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital mortality and need for invasive mechanical ventilation, trials of IL-6 receptor antagonists, effects of anticoagulants on in-hospital mortality, and symptom persistence in outpatients.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Evaluation of Abbott BinaxNOW (MMWR) * Lilly mAb in nursing homes (WSJ) * Vitamin D and COVID-19 severity (Mayo Clin Proc) * Anticoagulation, aspirin, in-hospital mortality in COVID-19 (medRxiv) * Long COVID symptoms in outpatients (Ann Int Med) * Letters read on TWiV 710 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2, and answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode * President’s science advisor to Cabinet (NY Times) * Letter from Biden to Lander (pdf) * Weekly flu (CDC) * Weekly NY flu (NYDOH) * WHO study on SARS-CoV-2 origins (WHO) * Letters read on TWiV 709 * Timestamps by Jolene. Thanks!
Weekly Picks Kathy – 15 YouTubers play Telestrations
Vincent – Vince Beiser
Listener Picks Bob, David, Janet – Sea Shanty by A Cappella Science (YouTube, TikTok, Bandcamp)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppress selection of neturalization-resistant variants.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * David Kessler to head Operation Warp Speed (NY Times) * Phase 1/2 results of Sinovac inactivated vaccine (Lancet) * beta-propiolactone (Wikipedia) * Multivalent anti-SARS-CoV-2 nanobodies (Science) * Letters read on TWiV 708 * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Photos of mob attacking Capitol
Brianne – Video of Neutrophil Phagocytosis
Alan – Fishing Through the Apocalypse
Rich – A Word on Statistics by Wislawa Szymborska
Vincent – Letters from an American
Listener Pick Mike – Have the new jab
Intro music is by Ronald Jenkees
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that encephalitis after SARS-CoV-2 infection is a cytokine release syndrome.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * J&J Ad26 vaccine phase 1/2 results (NEJM) * SARS-CoV-2 encephalitis is a cytokine release syndrome (CID) * Letters read on TWiV 707 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Poems are at Twiverse * 2020 US traffic deaths (Car & Driver) * National Vaccine Injury Compensation Program (HRSA) * Jet injector (Wikipedia) * Letters read on TWiV 706 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – We Know Almost Nothing About Giant Viruses
Rich – The Coccolithophores Project
Kathy – v-safe and Vaccine Handbook
Vincent – Gorillas at San Diego Zoo infected with SARS-CoV-2 (pdf)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Emily Travanty
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Links for this episode * VOC detected in Colorado (WaPo) * US has sequenced only 50,000 SARS-CoV-2 genomes (CDC) * Human CoV evolves to escape immunity (bioRxiv) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Randal Despommier on saxophone
Brianne – Giant Microbes SARS-CoV2
Alan – West of Loathing
Rich – Draft landscape of COVID-19 candidate vaccines
Vincent – SARS-CoV-2 spillover events
Listener Pick Daniel – His Vaccine Story Inspired His Father To Write A Disney Classic
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney disease, and provides further considerations on the use of Ct values in patient management.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Argentine study on plasma therapy (NEJM) * Ct values and clinical outcome (Open Forum Inf Dis) * Bamlanivimab fact sheet (FDA pdf) * Cognitive defects in recovered COVID-19 patients (medRxiv) * Letters read on TWiV 704 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to daniel@microbe.tv
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mortality, and dose-dependent response to SARS-CoV-2 infection of ferrets.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * BSL-3 Assistant Manager position * Follow authorized vaccine dosing schedule (FDA) * Mina suggests one vaccine dose (NY Times) * UK decision document on vaccine dose (pdf) * Ct linked to COVID-19 mortality (Open Forum Inf Dis) * Dose-dependent infection of ferrets (Nat Comm) * Letters read on TWiV 703 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Linsey Marr on masks
Kathy – Striped Martian Sand Dunes and
Rich – How Microwaving Grapes Makes Plasma
Vincent – Musings of an anonymous, pissed off virologist
Listener Pick Laura – Auld Lang Syne follow-up
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many listeners who turn to us for scientific facts.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Poems are at Twiverse * This little virus went to market (TWiV 581) * Host genetics initiative TWiV 628 * Inborn errors of immunity & serious COVID TWiV 671 * Lisa Gralinski TWiV 674 * Tragic gene flow from Neanderthals TWiV 676 * Ivermectin and COVID-19 (TWiV 599) * DC and Galveston road trips: TWiV 625, 643, 646, 589, 580, 583, 587) * Fauci and Hotez interviews (TWiV 641, 687) * Long-haul COVID, pro-thrombotic autoantibodies (TWiV 680, 683) * Minority health and disparities (TWiV 655) * Diversity in science (TWiV 672, 670) * SeXX matters (TWiV 624) * Kate Rubins (TWiV 682) * Laura Splan (TWiV 691) * Protective immune responses (TWiV 693, 685, 683) * Immune memory/cross-reactivity (TWiV 684, 681, 650, 631) * Timestamps by Jolene. Thanks!
Weekly Picks Dickson – Best of 2020 by NASA and The Plague Year
Brianne – Where Year Two of the Pandemic Will Take Us
Alan – Japan’s distinct form of vaccine hesitancy
Kathy – Paul Offit updates on the vaccine rollout and Choral Scholars of University College Dublin (John Greene’s videoessay on the song)
Rich – Do You Love Me?
Vincent – Story on Katalin Kariko’s career
Listener Pick Louise – Virus socks
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Attributes and predictors of long COVID-19 (medRxiv) * Letters read on TWiV 701 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca vaccine in the UK, and winners of the pandemic poem contest.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * BSL-3 Assistant Manager position * PHE update #2 (pdf) * South African variant (medRxiv) * CDC cautious in conclusions on variant * Afucosylated IgG and severe COVID-19 (Science) * AstraZeneca vaccine EUA in UK (BBC) * Letters read on TWiV 700 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Ready Player Two
Kathy – Bert Hubert’s Reverse Engineering of the Pfizer/BioNTech vaccine
Rich – Boston Dynamics running robots
Vincent – Fever by John Fuller
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira about their careers and their research on arthropod-borne viruses.
Host: Vincent Racaniello
Guests: Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira
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Links for this episode * RNAi in arbovirus-vector interactions (Viruses) * Arbovirus emergence via bridge vectors (Sci Rep) * Rift Valley fever (Trop Med Inf Dis) * Flavivirus infection and cerebrovascular events (Viruses) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antibody therapy, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Phased allocation of COVID-19 vaccines (ACIP slides) * How CDC is making COVID-19 vaccine recommendations (CDC) * Letters read on TWiV 698 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * BSL-3 Assistant Manager position 3:39 * NERVTAG meeting minutes (pdf) * NERVTAG * Preliminary genomic characterization of UK variant (virological.org) * PHE investigation of UK variant (pdf) * N501Y does not affect antibody neutralization (Science, eLife) * WHO notice on UK variant (WHO) * Liver tumor during AAV gene therapy (Science) * Letters read on TWiV 697 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – EM Rap Podcast COVID update
Kathy – Conjunction of Jupiter and Saturn and Tony Fauci vaccinated Santa Claus
Rich – Chicken LIttle (wiki)
Vincent – virological.org
Listener Pick Greg – Someone who wants to make a difference
Uli – XKCD on statistics
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration into the human genome, and lack of evidence for increased transmission by new variants in the UK.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * BSL-3 laboratory assistant manager position * FDA authorizes EUA for Moderna mRNA vaccine (FDA) * COVID-19 is not harmless for young adults (NY Times) * Excess mortality 25-44 years (JAMA) * Pfizer mRNA vaccine approved by FAA (AOPA) * SARS-CoV-2 RNA reverse transcription (bioRxiv) * Information on UK variant (GISAID, BMJ) * US agency computers compromised (WaPo) * DoD study on low risk of flying (WaPo) * When can children be vaccinated? (Guardian) * Letters read on TWiV 696 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – 2020 Audubon Photography Winners
Brianne – COVID-19 Changed Science Forever
Alan – Entangled Life by Merlin Sheldrake
Rich – Lie of the Year: Coronavirus downplay and denial; John 18:38
Vincent – How New York City Vaccinated 6 Million People in Less Than a Month (my article from 2009)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vaccine prevents infection, not just disease, monoclonal antibody therapy, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * FDA EUA for Pfizer mRNA vaccine (FDA) * Ellume at-home SARS-CoV-2 antigen test (Ellume) * Pre-K through grade 12 COVID-19 mitigation costs (MMWR) * Letters read on TWiV 695 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, and three-quarters attack rate of SARS-CoV-2 during an unmitigated epidemic in Brazil.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * BSL-3 Assistant Manager position * TWiV makes Bloomberg Business News 2020 Jealousy List (BBN) * Crushing of the CDC (NY Times) * Seasonal influenza during COVID-19 pandemic (jpg) * Moderna briefing documents (FDA) * Three-quarters attack rate in Brazil (Science) * Outdoor transmission of SARS-CoV-2 (J Inf Dis) * Rich Condit reminisces (YouTube) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Fears of a ‘Twindemic’ Recede as Flu Lies Low
Kathy – Faculty Equity & COVID-19 UM ADVANCE
Rich – ‘Sistine Chapel of the ancients’ rock art
Vincent – Winners of ASM Agar Art Contest 2020
Listener Pick Johnye – 2020 Year of the Vax t-shirt (and more)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * BSL-3 laboratory assistant manager position * FDA advisory committee votes in favor of EUA for Pfizer vaccine (NY Times) * Sanofi/Glaxo subunit vaccine steps back (Stat) * Efficacy of ChAdOx1 COVID-19 vaccine (Lancet) * Oral antiviral blocks SARS-CoV-2 transmission in ferrets (Nat Micro) * Letters read on TWiV 693 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – 2020 In Photos: A Year Like No Other
Brianne – Cooking for Geeks
Alan – On Food and Cooking
Rich – NASA Artemis (Wiki)
Vincent – The virus, the bats, and us
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aphasia, and much more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Mitigation strategies in early care and education settings (MMWR) * WHO solidarity trial results (NEJM) * Letters read on TWiV 692 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies induced by MMR vaccine and COVID-19 severity, and whether ivermectin is indicated for treatment of COVID-19.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Laura Splan
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Links for this episode * Laura Splan website * BSL-3 Assistant Manager position * MMR titers in recovered COVID-19 patients (mBio) * Ivermectin and SARS-CoV-2 (TWiV 599) * Treatment of COVID-19 with ivermectin (Int J Inf Dis) * Ivermectin approved dosing (Mayo Clinic) * Briefing document for Pfizer vaccine (FDA) * Vaccinated? Wear a mask (NY Times) * Efficacy of ChAdOx1 vaccine (Lancet) * Mix & Match Pfizer & Oxford jabs (Times Long) * SARS-CoV-2 seroprevalence in Seattle (medRxiv) * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Patterns for Virus snowflakes
Kathy – 2020 Nobel Prize lectures (hepatitis C) (link to all and concert) Historical review by Harvey Alter
Rich – New Data Confirm 2020 SO is Upper Centaur Rocket Booster from 1960’s (Wiki)
Vincent – The Right Stuff
Listener Pick Miikael – Tiny tweak behind COVID-19 vaccines
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Amy Rosenfeld
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Links for this episode * NYC will create pandemic response institute (NY Bus J) * Comparison of ACE2 in vertebrates (PNAS) * Olfactory transmucosal invasion of CNS by SARS-CoV-2 (Nat Neurosci) * Letters read on TWiV 690 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – National Geographic best animal photos of 2020
Amy – American Contagions: Epidemics and the law from Smallpox to COVID-19 by John Fabian Witt
Alan – HamSCI citizen science organization
Rich – DeepMind’s AI makes gigantic leap in solving protein structures
Vincent – Army Ants: Nature’s Ultimate Social Hunters by Daniel Kronauer
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more.
Hosts: Daniel Griffin and Vincent Racaniello
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Links for this episode * Vitamin D levels in COVID-19 patients (Nature) * ACIP recommendations for distribution of COVID-19 vaccine (MMWR) * Updated CDC guidance on when to quarantine (CDC) * Letters read on TWiV 689 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV 688: We put COVID-19 papers through a sieve December 2, 2020 On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an indication of viral replication.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * UK grants EUA for Pfizer vaccine (NY Times) * ACIP advice on who to vaccinate first (NY Times) * Das coronavirus update * SARS-CoV-2 protease regulates innate response (Nature) * Viral mRNAs do not indicate viral replication (Nat Comm) * Addendum to SARS-CoV-2 discovery paper (Nature) 16:15 * SARS-CoV-2 mRNA vaccine and GC formation (Immunity) 29:35 * What scientists say about masks (NY Times) 1:29:03 * Letters read on TWiV 688 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Pedromics
Kathy – Global map at Mars opposition
Rich – Janeway’s Immunobiology
Vincent – Janet Iwasa’s Animation Lab
Listener Pick Cheryl – BioRender.com holiday card templates
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for control, and whether we will be prepared for the next one.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Peter Hotez
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Links for this episode * Peter Hotez on TWiP 29 and TWiV Special * Wednesday, January 20, 2021 (Microbes Inf) * SARS-CoV-2 RBD protein vaccine candidate (bioRxiv) * Anti-science extremism in America (Microbes Inf) * Low cost accessible COVID-19 vaccine (PLoS NTD) * Letters read on TWiV 687 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – The World’s First Energy-Positive Hotel to Open in Norway
Brianne – The Food Lab: Better Home Cooking Through Science
Alan – ACIP’s ethical principles for COVID-19 vaccine allocation
Rich – The Mandolorian
Vincent – T. rex and the Crater of Doom by Walter Alvarez
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron’s monoclonal antibody and more.
Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email
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Links for this episode * WHO Solidarity trial for Remdesivir and other drugs (medRxiv) * EUA for Baricitinib (FDA) * EUA for Casirivimab and Imdevimab (FDA) * RCT: No benefit of convalescent plasma (NEJM) * Letters read on TWiV 686 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episode * AZD1222 vaccine efficacy (AstraZeneca) * Addendum to SARS-CoV-2 discovery paper (Nature) * SARS-CoV-2 mRNA vaccine and GC formation (Immunity) * What scientists say about masks (NY Times) * Letters read on TWiV 685 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Types of Scientists Coloring Book
Kathy – South Pole video
Rich – Steve Jobs by Walter Isaacson
Vincent – Screenology (I interviewed Deb Sklut here)
Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Shane Crotty
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Links for this episode * FDA authorizes Lucira mini home testing kit (FDA) * 60 day outcomes of COVID-19 patients (Annals Int Med) * Immunological memory to SARS-CoV-2 infection at 6 months (bioRxiv) * Letters read on TWiV 684 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – Benoit Mandlebrot’s 96 birthday
Brianne – #BlackinImmunoWeek
Rich – GoISSWatch ISS Tracking; Spot The Station (NASA)
Vincent – Microbes Rule
Listener Pick Agda – Sandwalk
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Efficacy of Moderna and Pfizer mRNA vaccines * Longer shelf life of Moderna vaccine (Moderna) * Prothrombotic antibodies in COVID-19 serum (Sci Trans Med) * Where is SARS-CoV-2 in the human body? (PLoS Path) * Letters read on TWiV 683 * Timestamps by Jolene. Thanks!
Weekly Picks Brianne – Picture a Scientist
Kathy – Colors of the Moon and Word that hasn’t changed
Rich – NASA YouTube channel
Vincent – Laura Splan science art
Listener Pick Mona – Ad5 vector and podcast with ImmunityBio founder
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.
Hosts: Vincent Racaniello and Rich Condit
Guest: Kate Rubins
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Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Kathleen A. Crowley
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Links for this episode * Pfizer vaccine efficacy (Pfizer) * Pfizer vaccine (Stat) * Distribution of Pfizer vaccine (NY Times) * LSTMH vaccine tracker * SARS-CoV-2 humans to mink and back in Netherlands (Science) * SARS-CoV-2 mink isolates in Denmark (pdf) * Preexisting antibodies to SARS-CoV-2 in humans (Science) * Letters read on TWiV 681 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – OSIRIS-REx | NASA
Brianne – Virtual Science Museum Tours
Alan – Ring Fit Adventure
Rich – BUGSS Baltimore Underground Science Space
Vincent – Trilobite glassworks
Listener Pick Gina and Joe – COVID Fan Tutte
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guests: Mady Hornig, Fiona Lowenstein, and David Tuller
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Links for this episode * Body Politic * Survivor Corps * Long-haulers redefining COVID-19 (Ed Yong) * I’m 26. Coronavirus sent me to the hospital (Fiona Lowenstein) * We need to talk about what coronavirus recoveries look like (Fiona Lowenstein) * COVID-19 long term disability (Mady Hornig, David Tuller) * At 12, she’s a COVID long-hauler (Davie Tuller) * NICE rejects GET, Lightning Process, CBT as cure (virology blog) * I want to scream (Occupy M.E.) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guests: Daniel Griffin and Amy Rosenfeld
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Links for this episode * Denmark will cull mink (Reuters) * State Serum Institute statement in Danish * Unethical to use SARS-CoV-2 human challenge studies (PNAS) * Nipah virus dynamics in bats (PNAS) * Spike-mediated cardiomyocyte fusion (ResearchSquare) * SARS-CoV-2 infects engineered heart tissues (bioRxiv) * You cannot lock up all risks groups (Das Coronavirus) * Letters read on TWiV 679 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – CNN News
Amy – I voted and Grace for President
Alan – The Story of More by Hope Jahren
Rich – OSIRIS-REx and 101955 Bennu
Vincent – The Vexed Muddler
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold higher SARS-CoV-2 exposure rate than reported cases in German children.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Nels Elde
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Links for this episode * Zebrafish virus discovery by visualization (Curr Biol) * Viral genome sequencing of White House COVID-19 outbreak (medRxiv) * Genetic signature of virus that may have infected Trump (NY Times) * Sixfold higher SARS-CoV-2 infection than reported in children (Med) * Letters read on TWiV 678 * Timestamps by Jolene. Thanks!
Weekly Science Picks Kathy – Why art is important and Tagging an asteroid
Rich – Vendee Globe
Vincent – PrePubMed
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more.
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Links for this episode * Daniel’s COVID-19 graph (Twitter) * Cornell U containment victory (Bloomberg) * Regeneron mAb trial paused (WSJ) * CLIAHUB (PLoS Path) * Serum antibodies to SARS-CoV-2 over time (paper one, two, three) * Letters read on TWiV 677 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – Comedy Wildlife Photography
Brianne – Ed Yong – Science reporting during a pandemic
Alan – Tree Story by Valerie Trouet
Rich – Boundless Body Radio Bethany and Casey Ruff
Vincent – Wearing is Caring
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
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Links for this episode * Genome wide association study of severe COVID-19 (NEJM) * Major genetic risk factor for severe COVID-19 inherited from Neanderthals (Nature) * COVID-19 host genetics initiative (Eur J Hum Gen) * Prolonged SARS-CoV-2 shedding in immunocompromised host (J Inf Dis) * Krugman on Barrington Declaration (NY Times) * Letters read on TWiV 676 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne – Kids Meet a Virologist
Kathy – Harvard glass marine invertebrates 3D online
Rich – Chernobyl fungi
Vincent – Artologica
Listener Pick Justin – Totally Under Control
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episode * Excess COVID-19 Deaths by Age and Race and Ethnicity (MMWR) * Excess COVID-19 deaths (JAMA) * SARS-CoV-2 transmission (CDC) * UK challenge trial (Nature) * Inflammatory cytokine signature for severe COVID-19 (Nature) * Death in AstraZeneca vaccine trial (Reuters) * Herpetic Legion – Reactivation (YouTube) * Tech position with Dr. Rosenfeld * Biological safety officer position at CUMC * Support MicrobeTV at Parasites Without Borders * Foege letter to Redfield (text, NPR article) * False promise of herd immunity (Nature) * Secret vaccine plans released (NY Times) * Neuropilin-1 and SARS-CoV-2 entry (paper one, two) * Letters read on TWiV 675 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – Nikon Small World Photography Competition
Brianne – Modeling Herd Immunity for measles
Alan – Small Gods by Terry Pratchett
Rich – Boundless Body Radio Bethany and Casey Ruff
Vincent – The Twenty-One Balloons by William Pene du Bois
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a potential analgesic, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Lisa Gralinski
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Links for this episode * SARS-like bat CoV with potential for human emergence (Nat Med) * SARS-CoV susceptibility loci in CC mice (PLoS Genetics) * Combination attenuation for SARS-CoV vaccine (J Virol) * Orally administered SARS-CoV-2 antiviral (Res Sq) * Spike protein induces analgesia (Pain) * Letters read on TWiV 674 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne – The Lonely Pipette Podcast: Mentoring with Harmit Malik
Kathy – Dr. Boyd the Chemist one and two GREAT short videos one and two, How to read an old school thermometer, New Marvel storyline Wear a Mask parody of Be My Guest
Rich – Clear+Vivid with Alan Alda
Vincent – Immune 36: Aberrant immunity in COVID-19
Listener Pick Ryan – Dr. Fauci on politicization of pandemic
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thrombosis in SARS-CoV-2 infected humans and rhesus macaques, and the ability of the swine pathogen SADS-CoV to infect human respiratory tract cells.
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Links for this episode * Daniel’s COVID-19 testing strategy calculator (and medRxiv preprint) * US COVID-19 mortality rates (JAMA) * Final remdesivir report (NEJM) * Hydroxychloroquine for COVID-19 (NEJM) * Tech position with Dr. Rosenfeld * Biological safety officer position at CUMC * Support MicrobeTV at Parasites Without Borders * Smell and taste changes as early pandemic indicators (Nat Comm) * Vascular disease and thrombosis in SARS-CoV-2 infected macaques (Cell) * SADS-CoV can infect human airway cells (PNAS) * Letters read on TWiV 673 * Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson – The Age of Nature
Brianne – Virologist, Immunologist, Science Communicator pins and Virus Earrings
Alan – Sharks, Squalene, and a SARS-CoV-2 Vaccine
Rich – 6th Annual Science Mill Benefit
Vincent – The Evolution of Infectious Disease by Paul Ewald
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studies of Regeneron's SARS-CoV-2 monoclonal antibody cocktail, reinfection of a patient in Nevada, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Ari Kozik and Kishana Taylor
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Links for this episode
- Black microbiologists push for visibility (NY Times)
- Black in Microbiology keynotes (YouTube)
- Black in Microbiology
- Black in Neuro
- AstroKate rides again (and on TWiV 444)
- COVID-19 testing strategy calculator (and medRxiv preprint)
- Pause of J&J vaccine trial (STAT)
- Pause of Lilly mAb trial (NY Times)
- REGN-CoV-2 mAbs in animals (Science)
- Regeneron investor slides on mAb phase 3
- SARS-CoV-2 reinfection in US (Lancet Inf Dis)
- Letters read on TWiV 672
- Timestamps by Jolene. Thanks!
Weekly Science Picks
Brianne - A Lab of One's Own by Rita Colwell
Kathy – Endonym map
Rich - “The Coronavirus Unveiled” by Carl Zimmer
Vincent - Principles of Virology 5th Edition
Listener Pick
Les - Coronavirus cake
Mary - Choir finds a way to sing
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghanistan, inborn errors of interferon in patients with severe COVID-19, and listener questions.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guests: Daniel Griffin and Amy Rosenfeld
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Links for this episode
- ASH guidelines on anticoagulants in COVID-19 patients (ASH)
- Followup of adults with noncritical COVID-19 (Clin Micr Inf)
- Tocilizumab in COVID-19 ICU patients (Lancet Rheum)
- Tech position with Dr. Rosenfeld
- Biological safety officer position at CUMC
- Support MicrobeTV at Parasites Without Borders
- 2020 Nobel Prize Chemistry (pdf)
- Progress towards polio eradication Afghanistan (MMWR)
- Inborn errors of IFN and serious COVID-19 (Science)
- Letters read on TWiV 671
- Timestamps by Jolene. Thanks!
Weekly Science Picks
Amy - Coronavirus : A book for children by Kate Wilson and Nia Roberts
Alan - Lost Prologue
Rich -RAPS COVID-19 vaccine tracker
Vincent - A Crack in Creation by Doudna and Sternberg and Sternberg on TWiM 184
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and testing of a spike-encoding mRNA vaccine, and then we review the Nobel Prize for discovery of hepatitis C virus.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Kizzmekia Corbett
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Links for this episode
- Pre-fusion structure of CoV spike (Nature)
- Pre-fusion structure of SARS-CoV-2 spike (Science)
- Evaluation of mRNA-1273 in nonhuman primates (NEJM)
- SARS-CoV-2 vaccine from pandemic preparedness (Nature)
- Nanoparticulate universal influenza vaccine from stem antigens (mBio)
- Biological safety officer position at Columbia U
- Medicine Nobel Prize for Hepatitis C virus (pdf)
- Alter's work on non-A non-B hepatitis (paper one, paper two)
- Houghton: single clone of HCV genome (Science)
- Rice: Transmission of hepatitis C to chimpanzee (Science)
- Charlie Rice on TWiV 392
- Chemistry Nobel Prize to Doudna and Charpentier (Nobel.org)
- FDA releases stricter guidelines for COVID-19 vaccines (NY Times, FDA pdf)
- Bullet points of Das coronavirus
- Recovery of 1918 influenza virus stories (one, two)
- Letters read on TWiV 670
- Timestamps by Jolene. Thanks!
Weekly Science Picks
Brianne - COVID-19 in Molecular Detail for Teaching
Kathy – Mars shining brightest since 2003
Rich - Lost Prologue
Vincent - Girl from Ipanema is weirder than you thought
Listener Pick
Sandra - Learn Medical Research
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks.
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Links for this episode
- Regeneron CoV-2 mAb cocktail results (Regeneron)
- Rethinking COVID-19 test sensitivity (NEJM)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the pandemic, evidence that the D614G amino acid change improves transmission in hamsters, and listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Daniel Griffin, Michael B. Yaffe, and Christopher D. Barrett
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Links for this episode
- Regeneron CoV-2 mAb cocktail results (Regeneron)
- Vitamin D and COVID-19 (Lancet Diabet Endocrin)
- J&S Ad26 SARS-CoV-2 vaccine phase 1/2a results (medRxiv)
- All the wrong moves (Science Signaling)
- Trump main drive of CoV misinformation (NYTimes)
- Surgisphere scandal (The Scientist)
- SARS-CoV-2 D614G earlier transmission in vivo (bioRxiv)
- Das Coronavirus bullet points
- Letters read on TWiV
- Timestamps by Jolene. Thanks!
Weekly Science Picks Dickson - Why we should all wear masks
Brianne - Milestones in Vaccines
Rich - Wallpaper/fabric designs by David Goodsell
Vincent - Das Coronavirus bullet points and a new t-shirt
Listener Pick Justin - COVID Alert NY App | Department of Health
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Tony Schountz
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Links for this episode
- SARS-CoV-2 infection of deer mice (bioRxiv)
- Infection of Jamaican fruit bats with MERS-CoV (Sci Rep)
- Immunological control of virus infections in bats (Front Immunol)
- Transmission of bat influenza viruses in bats (Nat Micro)
- Letters read on TWiV 668
- Timestamps by Jolene. Thanks!
Weekly Science Picks
Brianne - Virus Masks
Kathy – UV in the vineyards (video)
Rich - Great White Shark Attack
Vincent - Smart WiFi garage door opener
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Daniel Griffin
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Links for this episode
- Safety and immunogenicity of Russian COVID-19 vaccine (Lancet)
- 'Questionable' data in Russian vaccine results (Nature)
- Mouse model for SARS-CoV-2 ALI and mortality (Cell)
- Letters read on TWiV 667
- Letters to Humans
- Timestamps by Jolene. Thanks!
Weekly Science Picks
Dickson - Rewilding Europe
Alan - How to Do Nothing by Jenny Odell
Rich - Gene drive engineered mosquitoes
Vincent - TWiEVO 60 with 12 guests!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airplane flights, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: David Brenner
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Links for this episode
- Far-UVC light inactivates viruses (paper one and two)
- Tips to avoid mask fogging (YouTube, article one and two)
- Funding for virus hunting
- Jonna Mazet interview (YouTube)
- Pandemic fake news (NY Times)
- Airplane SARS-CoV-2 infections (summary, article one, two, three)
- COVID-19: Wrong moves in wrong places (Science)
- Das coronavirus bullet points
- SARS-CoV-2 was not made in a lab (YouTube)
- Letters read on TWiV 666
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
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Links for this episode
- Increased risk for COVID-19 during pregnancy (MMWR)
- COVID-19 and community and close contact exposures (MMWR)
- COVID-19 clusters in Japan (Emerg Inf Dis)
- Eyeglass use associated with less COVID-19 (JAMA Ophthal)
- Superspreading of SARS-CoV-2 in Hong Kong (Nat Med)
- HKU1 HE structure and evolution (Nat Comm)
- Das Coronavirus summaries
- TWiVerse
- Letters read on TWiV 665
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
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Links for this episode
- Coronavirus is mutating (Nature)
- Seasonal CoV immunity is short (Nat Med)
- Sorry, no link to the fake science document!
- Letters read on TWiV 664
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B cells in recovered patients, and listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
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Links for this episode * Young adults with COVID-19 (JAMA) * Letter from Stanford professors on Atlas (pdf) * National Adult and Influenza Immunization Summit * Bugger, even the snapping turtles! (PLoS One) * Memory B cell longevity in COVID-19 (medRxiv) * Letters read on TWiV 663 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses.
Host: Vincent Racaniello
Guests: Jane Flint, Anna Marie Skalka, Glenn F. Rall, and Theodora Hatziioannou
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Links for this episode
- Purchase PoV 5e Volumes 1 + 2 (link)
- Purchase PoV 5e Volume 1 (link)
- Purchase PoV 5e Volume 2 (link)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will happen this fall.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Ralph Baric
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- Broadly neutralizing sarbecovirus mAbs (bioRxiv)
- Evaluation of mRNA-1273 in nonhuman primates (NEJM)
- Bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 (bioRxiv)
- Mouse-adapted SARS-CoV-2 (bioRxiv)
- READDI
- Das Coronavirus summaries in English
- ChAdOx1 vaccine trial halted (NY Times)
- Impact of high frequency screening (medRxiv)
- Letters read on TWiV 661
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccines before completion of phase 3 trials, and absence of evidence for infectious virus in aerosols.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Daniel Griffin
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Links for this episode
- Convalescent plasma RCT (medRxiv)
- Multicenter RCTs on corticosteroids for COVID-19 (JAMA)
- Decline of influenza B cells a year after vaccine (Science)
- Be ready to distribute vaccines 1 Nov (WPRI and NYTimes)
- EUA during COVID-19: lessons (JAMA)
- Not evidence for aerosol transmission (one and two)
- Letters read on TWiV 660
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Christian Drosten
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Links for this episode
- Christian previously on TWiV 601
- Plague percolation phenomenon (Nature)
- TMPRSS2 inhibitor for SARS-CoV-2 (Cell)
- Repeated infections with endemic CoV (J Inf Dis)
- Koch Institute SARS-CoV-2 reports
- Letters read on TWiV 659
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email.
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit
Guest: Daniel Griffin
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Links for this episode
- CDC told to soften SARS-CoV-2 testing guidelines (NYTimes)
- Moderna investor presentation on mRNA-1273 vaccine (link)
- SARS-CoV-2 reinfection (Clin Inf Dis)
- Dr. Fauci talks with just about anyone (NYTimes)
- Letters read on TWiV 658
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Shane Crotty
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Links for this episode
- Ahead of the Curve by Shane Crotty
- SARS-CoV-2 T cell epitopes (Cell)
- Cross-reactive CoV T cell epitopes (Science)
- Knowns and unknowns about SARS-CoV-2 immunity (Nat Rev Imm)
- Letters read on TWiV 657
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and ethnic disparities among COVID-19 cases, no more premarket review of laboratory developed tests by FDA; and emergency use authorization of convalescent plasma is on hold.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
Guests: Daniel Griffin, Lisa A. Smith, and W. David Bruce
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Links for this episode
- Racial and ethnic disparities in workplace COVID-19 (CDC)
- Rescission of guidances on laboratory tests (FDA)
- EUA on convalescent plasma on hold (NY Times)
- Letters read on TWiV 656
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Robert Fullilove
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Links for this episode
- Health of racial and ethnic minority groups (CDC)
- COVID-19 death/hospitalization by race/ethnicity (CDC)
- Racial and ethnic disparities in workplace COVID-19 (CDC)
- SalivaDirect EUA (FDA)
- Adenovirus vectored SARS-CoV-2 experimental vaccine protects mice (Nat Comm)
- Letters read on TWiV 655
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina testing, transmission, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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- Daniel's recommendations for COVID-19 testing (pdf)
- Effects of convalescent plasma on COVID-19 (medRxiv)
- ESCV virtual meeting on COVID-19
- The Russian Vaccine (In The Pipeline)
- Russia's vaccine approval (Science)
- Letters read on TWiV 654
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic.
Hosts: Vincent Racaniello and Rich Condit
Guests: Alfonso Landeros, Ken Lange, Mary E. Sehl, and Janet Sinsheimer
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Links for this episode
- School reopening strategies (medRxiv)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how this one will end.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Adam Kucharski
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Links for this episode
- The Rules of Contagion (Amazon affiliate link)
- Overdispersion in SARS-CoV-2 transmission (Wellcome Open Res)
- Sorrento Therapeutics test
- In vitro diagnostics EUAs (FDA)
- Letters read on TWiV 652
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, and diagnostic tests during a pandemic, followed by answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Denise Esposito
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Links for this episode
- Template for at-home, OTC diagnostic tests (FDA)
- Postdoctoral position in Prasad laboratory (pdf)
- Rapidtests.org
- Masks are cool, Miasma t-shirts (CafePress)
- Letters read on TWiV 651
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from COVID-19, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode
- Travis County indicators dashboard
- SARS-CoV-2 transmission at an overnight camp (MMWR)
- Adaptation of SARS-CoV-2 in mice (Science)
- Acute SARS-CoV-2 infection impairs DC and T cell responses (Imm)
- Boulder, Columbia, Illinois rapid saliva tests
- Letter drafts for $1 testing
- Letters read on TWiV 650
- Timestamps by Jolene. Thanks!
Weekly Science Picks
KathyBBC Witness History, Maurice Hilleman 9 minute audio (quotes by Paul Offit) “The fastest vaccine ever developed”And APOD Picture Rocks Sun Dagger
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coronaviruses, paramyxoviruses, and environmental viruses.
Host: Vincent Racaniello
Guests: Shan-Lu Liu, David Bisaro, Amanda Panfill, Mark Peeples, Matt Sullivan, Chris Walker, Qiuhong Wang
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Links for this episode
- New virus requires international control (Nature)
- TIM-family proteins inhibit HIV-1 release (PNAS)
- Designing a HCV vaccine (Curr Op Virol)
- Attenuated vaccines for RSV in children (J Inf Dis)
- Plant histone reader suppresses geminivirus infection (J Virol)
- HTLV-associated malignancy (Curr Op Virol)
- Coronaviruses in pigs (Curr Op Virol)
- Marine DNA viral diversity pole to pole (Cell)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage giving rise to SARS-CoV-2 has been circulating in bats in China for decades, and answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin and Chuck Knirsch
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Links for this episode
- Roche trial of Actemra for COVID-19 fails (Reuters)
- Postdoctoral position at RML
- Shedding of SARS-CoV-2 at different ages (JAMA Ped)
- Evolutionary origins of SARS-CoV-2 (Nat Microbio)
- Letters read on TWiV 648
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode
- Children do transmit infection (Emerg Inf Dis)
- NIH RADx initiative (NEJM)
- Rockefeller Foundation testing plan
- HCQ observational study (Int J Inf Dis)
- Can't kill HCQ (Science Based Medicine)
- HCQ does not inhibit SARS-CoV-2 in human lung cells (Nature)
- HCQ does not inhibit SARS-CoV-2 in nonhuman primates (Nature)
- Shut-down to stop SARS-CoV-2 (WaPo)
- Racine firefighters doing LAMP (Wired)
- LAMP (video, webinar, paper 1, paper 2)
- Letter drafts for $1 testing
- Letters read on TWiV 647
- Timestamps by Jolene. Thanks!
Weekly Science Picks Kathy - Vertical Farms Fill a Tall Order by Dickson Despommier and APOD
Rich - Mars in 4K
LIstener Pick Christiane - ZSK - Ich habe Besseres zu tun (Official Video) Drosten
Jon - The Logic of Doomsday
Intro music is by Ronald Jenkees
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From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses.
Hosts: Vincent Racaniello and Rich Condit
Guest: Eugene Koonin
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Links for this episode
- Virocentricity with Eugene Koonin (TWiV 275)
- Origin of viruses (Nat Rev)
- Multiple origins of capsid proteins from cells (PNAS)
- Origins and evolution of global RNA virome (mBio)
- Evolution of NCLDV of eukaryotes (Adv Virus Res)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx Zoo, and, answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Daniel Griffin
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Links for this episode
- State Dept. memo on Wuhan BSL-4 lab (pdf)
- Biosafety levels (Wikipedia)
- Inside a BSL-4 (TWiV)
- From people to panthers (bioRxiv)
- Letters read on TWiV 645
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary phase I/II results of the ChAdOx1 SARS-CoV-2 vaccine, answers to listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Download TWiV 644 (69 MB .mp3, 115 min)
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Links for this episode
- US COVID-19 cases (NY Times)
- Identify flawed research before it is dangerous (NY Times)
- Mask up, America! (NY Times)
- $1.95 billion to Pfizer (NY Times)
- Phase I trial of Pfizer mRNA vaccine (medRxiv)
- Phase I/II trial of ChAdOx1 vaccine (Lancet)
- Rockefeller Foundation testing plan
- TWiV 640 on MedCram
- Letter drafts for $1 testing
- Letters read on TWiV 644
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses.
Hosts: Vincent Racaniello and Rich Condit
Guest: Bernie Moss
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Link for this episode
- Reflections on Bernie Moss' career (JBC)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Links for this episode
- Travis County virtual Town Hall
- SARS-CoV-2 mRNA vaccine, preliminary results (NEJM)
- Factors associated with COVID-19 death (Nature)
- Letters read on TWiV 642
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness.
Hosts: Vincent Racaniello and Rich Condit
Guest: Dr. Anthony Fauci
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Dr. Fauci was previously on TWiV 219
Intro music is by Ronald Jenkees
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Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Michael Mina
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Links for this episode
- Michael Mina on Immune 26
- White House bypasses CDC (NY Times)
- Test sensitivity is secondary to frequency and turnaround time (medRxiv)
- Group testing for SARS-CoV-2 (medRxiv)
- Consider the cycle threshold value (Clin Inf Dis)
- MERS-CoV spike nanoparticles protect mice from infection (Vaccine)
- CoV spike protein nanoparticles induce neutralizing antibodies in mice (Vaccine)
- Letters read on TWiV 640
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV-1, human papillomaviruses and much more.
Host: Vincent Racaniello
Guest: Erling Norrby
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Links for this episode
- Nobel Prizes and Life Sciences by Erling Norrby
- Nobel Prizes and Nature’s Surprises by Erling Norrby
- Nobel Prizes and Notable Discoveries by Erling Norrby
- Nobel Prizes: Cancer, Vision and the Genetic Code by Erling Norrby
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
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Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guests: Viviana Simon, Daniel Griffin and Chuck Knirsch
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Links for this episode
- Serological assay for SARS-CoV-2 infection (Nat Med)
- Early spread of SARS-CoV-2 in NYC (Science)
- Seroconversion of a city (medRxiv)
- Immune response and PCR positivity of NYC cohort (medRxiv)
- Letters read on TWiV 638
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode
- China approves COVID-19 vaccine for military (CNN)
- Ad5-vectored COVID-19 vaccine phase I results (Lancet)
- US pays $1.6 billion for Novavax vaccine (NY Times)
- CEPI awards $388 million to Novavax (Novavax)
- HHS on Novavax vaccine (HHS)
- Novavax phase I/II trials (GlobeNewswire)
- Prevalence of SARS-CoV-2 in Spain (Lancet)
- Shedding and transmissibility of SARS-CoV-2 (Nature)
- Letters read on TWiV 637
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development.
Host: Vincent Racaniello
Guests: Chris Basler, Andrew Gewirtz, Priya Luthra, and Richard Plemper
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Links for this episode
- Mutant Ebolavirus lacks virulence (Cell Rep)
- Blocking Ebolavirus replication by depleting nucleoside pools (Antiviral Res)
- Herd immunity against bad actor molecules (PloS Path)
- Bacteria prevent and cure rotavirus infection (Cell)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Links for this episode
- Infectious SARS-CoV-2 in nasopharynx of youth (Emerg Inf Dis)
- SARS-CoV-2 viral load by patient age (Hosp Charité)
- Viral load in children with COVID-19 (Emerg Inf Dis)
- Role of children in SARS-CoV-2 transmission (virology blog)
- Letters read on TWiV 635
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine approval, and answer listener email.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker
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Links for this episode
- New swine flu with pandemic potential (BBC, PNAS)
- Oral SARS-CoV-2 vaccine candidate (ClinicalOmics)
- Operation Warp Speed (HHS)
- ACTIV (NIH)
- Development and licensure of COVID-19 vaccines (FDA)
- Letters read on TWiV 634
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA.
Host: Vincent Racaniello
Guests: Sheemei Lok, Dahai Luo, Eng Eong Ooi, and Ashley St. John
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Links for this episode
- Dengue virus and endothelial permeability (J Clin Invest)
- Dengue virus morphological switch (PLoS Path)
- Symptomatic yellow fever vaccine infections (Nat Med)
- RNA recognition by RIG-I and MDA5 (Nucl Acids Res)
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Links for this episode
- Dexamethasone for COVID-19 (medRxiv)
- Proning trial for COVID-19 (Lancet)
- Tocilizumab for COVID-19 cytokine storm (Chest)
- Global causes of death
- Vesicular stomatitis in horses (ProMedMail)
- Daily tests needed (Atlantic)
- SARS-CoV-2 infection risks
- Letters read on TWiV 632
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episode
- Probability of symptoms and severe COVID-19 (aRxiv)
- Cellular immune response without seroconversion (medRxiv)
- Image credit
- Letters read on TWiV 631
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes containing Wolbachia endosymbionts to inhibit viral transmission.
Host: Vincent Racaniello
Guest: Lee Ching Ng
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Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email.
Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove
Guests: Daniel Griffin and Chuck Knirsch
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Links for this episode
- Dexamethasone reduces COVID-19 deaths (U Oxford)
- Assessment of asymptomatic COVID-19 (Nature Med)
- Age-dependent effects on SARS-CoV-2 transmission (Nature Med)
- Image credit
- Letters read on TWiV 629
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email.
Hosts: Vincent Racaniello and Rich Condit
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Links for this episode
- Austin TX key indicators for staging
- D614 amino acid change (Scripps)
- Virus shedding in hospitalized patients (medRxiv)
- Hamster SARS-CoV-2 model (Nature)
- COVID-19 host genetic initiative
- Image credit
- Letters read on TWiV 628
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore.
Host: Vincent Racaniello
Guests: Leo Yee-Sin and Nancy Tee
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Links for this episode
- National Centre for Infectious Diseases
- National Public Health Laboratory
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric
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Links for this episode
- Mouse-adapted SARS-CoV-2 model (bioRxiv)
- SARS-CoV-2 mRNA vaccine (bioRxiv)
- ASM resources for #shutdownstem
- President Obama on sustaining momentum for change (Facebook)
- America After the Civil War (PBS)
- Image credit
- Letters read on TWiV 626
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.
Hosts: Vincent Racaniello and Rich Condit
Guest: Frederick A. Murphy
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Link for this episode
- (UTMB)
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.
Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein
Click arrow to play
Download TWiV 624 (91 MB .mp3, 152 min)
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Links for this episode
- SeXX matters in infectious disease pathogenesis (PLoS Path)
- Sex and gender impact immune responses to vaccines (Physiol)
- Testosterone and disease severity in mice (Cell Immunol)
- Age-associated effects on impact of sex steroids on vaccine responses (NPJ Vaccines)
- Evolution of greater humoral immunity in females (Curr Opin Physiol)
- Impact of sex and gender on COVID-19 (Biol Sex Diff)
- COVID-19 trials should include sex as variable (J Clin Inves)
- Global Health 50/50
- Image credit
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Peter Daszak
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Links for this episode
- Bats are reservoirs of SARSr-CoV (Science)
- Bat SARSr-CoV that binds ACE2 (Nature)
- Rich gene pool of bat SARSr-CoV (PLoS Path)
- Bat SARSr-CoV infect humans (Virol Sin)
- Transmission of bat SARSr-CoV in China (bioRxiv)
- Global Virome Project (Science)
- ASV Virtual Workshops 2020
- Image credit
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Emmie de Wit
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Links for this episode
- Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature)
- Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv)
- Remdesivir for MERS-CoV infection in macaques (PNAS)
- ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv)
- Image credit
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.
Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guests: Daniel Griffin and Chuck Knirsch
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Links for this episode
- Safety of Ad5 vectored COVID-19 vaccine (Lancet)
- Analysis of hydroxychloroquine use (Lancet)
- Remdesivir study (NEJM)
- Ancient COVID-19 history (MMWR)
- Drug repurposing for COVID-19 (bioRxiv)
- Why do few COVID-19 patients infect others? (Science)
- Overdispersion in COVID-19 transmission (Wellcome Open Res)
- Reducing airborne transmission (Science)
- Letters read on TWiV 621
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Jon Yewdell
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Links for this episode * T cell targets in COVID-19 patients (Cell) * SARS-CoV-2 seroconversion in humans (Nat Med) * Convergent antibody responses to SARS-CoV-2 infection (bioRxiv) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
Guest: Raul Rabadan
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Links for this episode * Rabadan Laboratory * Understanding Coronavirus (Amazon) * Topological Data Analysis for Genomics and Evolution (Amazon) * Recombination and mutation shaped SARS-CoV-2 (bioRxiv) * Bat CoV with cleavage site insertion (Curr Biol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.
Hosts: Vincent Racaniello
Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang
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Intro music is by Ronald Jenkees.
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Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Daniel Griffin
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Links for this episode * Playing tennis safely (USTA) * Scientists denounce end to CoV grant (NY Times) * ASMBMB denounces end to CoV grant (pdf) * For TETRIS, turn to Paterson NJ (NY Times) * NJ Dept of Health (image credit) * Differential effects of intervention timing (medRxiv and NY Times) * Texas to stop combining test results (Statesman) * How could CDC make that mistake? (Atlantic) * The Pandemic and Information Network (Columbia Journ Rev) * Helmet and tent (Science) * New song, old melody (Cell Host Microbe) * Letters read on TWiV 617 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode * Drowning in COVID-19 papers (Science) * CORD-19 * 2019 NCRC * AI powered literature review * SciSight * Graphical guide to CoV vaccines (Nature) * Moderna Phase I results * Liposomes and lipid nanoparticles (Exelead) * Cigarette smoke increases ACE2 (Dev Cell) * Letters read on TWiV 616 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.
Hosts: Vincent Racaniello
Guests: Peter Daszak
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Intro music is by Ronald Jenkees.
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Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
Guest: Daniel Griffin
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Links for this episode * Triple therapy for COVID-19 (Lancet) * Virology podcast goes viral (Thalia Gigerenzer) * Paul Stays Home (pdf) * Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell) * Mumbai engulfed by CoV (NY Times) * All must be vaccinated (Stat) * FDA concerns with Abbott test (FDA) * How US lost 6 weeks (BBC) * Image credit * Letters read on TWiV 614 * 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode * COVID-19 brings out dark side of science (Mother Jones, Wired) * Jenner Institute COVID-19 vaccine (BioSpace) * Recombineering (Nucleic Acids Res) * Vaccines lecture (YouTube) * ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis) * Chimpanzee adenovirus vector (PLoS One) * Ad-MERS vaccine protects monkeys (NIH) * Rapid COVID-19 vaccine development (Science) * Strategic approach to COVID-19 vaccines (Science) * NIH decision to stop remdesivir study (Stat) * 80,000 flu deaths this winter (Stat) * Science and singing (YouTube) * COVID-19 at choir practice (Emerg Inf Dis) * 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.
Hosts: Vincent Racaniello
Guests: Richard Hatchett and Linfa Wang
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Intro music is by Ronald Jenkees.
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Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guests: Daniel Griffin and Michael Schmidt
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Links for this episode * OSHA guidance for dentistry * COVID0-19 challenges for dentistry (J Dent Res) * COVID-19 and dentistry (Int J Env Res Pub Health) * Mouthrinses for dentistry (J Clin Med) * Disingenuous plandemic documentary (Big Think) * Letters read on TWiV 611 * Image credit * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * FDA revises statement on antibody tests (FDA) * Serology-based tests for SARS-CoV-2 (Center for Health Security) * ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study) * Global COVID-19 CFR (CEBM) * Debunking transmission mutation: TWiEVO 55 * Letters read on TWiV 610 * Image credit * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Susan Weiss
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Links for this episode * Coronaviruses by Susan Weiss (YouTube) * Forty years with coronaviruses (JEM) * No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect) * CoV and antagonism of RNAse L (mBio) * Exoribonuclease needed for MHV innate antagonism (J Virol) * RNAse L and ADAR (eLife) * Emerging viruses respiratory award (Amer Lung Assoc) * Image credit * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.
Hosts: Vincent Racaniello and Rich Condit
Guest: Daniel Griffin
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Links for this episode * Pulmonary embolism in COVID-19 (Emerg Inf Dis) * Patch Study * Remdesivir in adults with severe COVID-19 (Lancet) * ACTT remdesivir trial (NIAID) * Commentary on remdesivir trials (Lancet) * FDA expected to issue remdesivir EUA (Contaigon Live) * Recovered COVID-19 patients wrong (Korea Herald) * Letters read on TWiV 608 * Image credit * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jeff Shaman
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Links for this episode * COVID-19 findings and simulations (Shaman Lab) * Reconciling diverse estimates of infection rates (pdf) * Undocumented SARS-CoV-2 infections (Science) * Simulations of SARS-CoV-2 spread (pdf) * Repeated infections with diverse CoV (pdf) * Letters read on TWiV 606 * Image credit * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Daniel Griffin
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Links for this episode * Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) * Saliva is more sensitve than nasopharyngeal swab (medRxiv) * NY serological survey results (NY Times) * FDA caveats on serological tests (FDA) * Federal guidelines on when to open * When to open: Roadmap, blog, video explainer * Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) * Lawmakers want human challenge studies (Science) * Letters read on TWiV 606 * Image credit * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ralph Baric, Mark Heise, and Nat Moorman
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Links for this episode * READDI.org * CEPI * DNDi * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.
Host: Vincent Racaniello
Guest: Kostya Chumakov
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Links for this episode * Nonpathogenic enteroviruses to prevent human disease (pdf) * OPV for COVID-19 (pdf) * Enteroviruses to prevent human infections (pdf) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Daniel Griffin
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Links for this episode * CpG frequency in SARS-CoV-2 genome (Mol Biol Evol) * SARS-CoV-2 screening before delivery (NEJM) * SARS-CoV-2 seroprevalence in Santa Clara (medRxiv) * SARS-CoV-2 seroprevalence in homeless shelter (NEPR) * Letters read on TWiV 603 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Stanley Perlman
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Links for this episode * Perlman Laboratory * An Iowa Caucus of Viruses (TWiV 538) * Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) * T cell responses to respiratory CoV (Immunol Res) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.
Host: Vincent Racaniello
Guest: Christian Drosten
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Links for this episode * Das Coronavirus podcast * Identification of SARS-CoV in Germany (NEJM) * 29 nt deletion in genome of SARS-CoV (Sci Rep) * 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) * Virological assessment of COVID-19 patients (Nature) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Daniel Griffin
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Links for this episode * 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) * Recombination and mutation leading to SARS-CoV-2 (bioRxiv) * Letters read on TWiV 600 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Guest: Doris Cully
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Links for this episode * Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) * Tiger at NY zoo positive for SARS-CoV-2 (NY Times) * IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv) * Infection fatality rate for managing pandemic (virology blog) * Image credit * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2.
Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler
Guest: Daniel Griffin, MD
Download TWiV 598 (70 MB .mp3, 115 min)
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Links for this episode * Restricted dispensing of Plaquenil in NY state * Virology of COVID-19 patients (Nature) * Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv_ * Cloth face masks for all of US (NY Times) * Masks and respiratory virus shedding (Nat Med) * 50 million face masks to Japanese households (Kyodo News) * More than you want to know about face masks (Slate Star Codex) * Why is COVID-19 less severe in children? (virology blog) * Tracking SARS-CoV-2 in sewage (UM) * 1918 flattening the curve (Nat Geo) * COVID near you * Pandemic stops polio eradication (Science) * SARS-CoV-2 vaccine patch in mice (U Pitt) * Letters read on TWiV 595 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2.
Hosts: Vincent Racaniello and Rich Condit
Guest: Jon Yewdell
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Intro music is by Ronald Jenkees.
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TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
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Links for this episode * Emergency use of hydroxychloroquine (FDA) * Trial of hydroxycholorquine in COVID-19 patients (China, France) * COVID-19 in critically ill patients, Seattle (NEJM) * Feasibility of convalescent plasma therapy for COVID-19 (medRxiv) * Letters read on TWiV 596 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2.
Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Daniel Griffin, MD
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Links for this episode * Tocilizumab (Wiki) * Nares swab for SARS-CoV-2 (Star Trib) * US SARS-CoV-2 epidemic curve (CDC) * Cleaning and disinfecting (CDC) * Cleaning fruits and vegetables (FDA) * Coronavirus food safety (FDA) * Vaccine development for SARS-CoV-2 (pdf) * Image by Michele Banks * Letters read on TWiV 595 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more.
Hosts: Vincent Racaniello
Guest: W. Ian Lipkin
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Links for this episode * Center for Infection and Immunity * Control the Contagion videos * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.
Hosts: Vincent Racaniello
Guest: Mark Denison
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Intro music is by Ronald Jenkees.
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A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Coronavirus test kit * Rapid SARS-CoV-2 serological assay (medRxiv) * Is Dr. Fauci in trouble? (NY Times) * FDA approves emergency use of convalescent serum (FDA) * Image by Michele Banks * Letters read on TWiV 594 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Daniel Griffin, Ori Lieberman, and Valeria Cagno
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Links for this episode * Pregnancy and COVID-19 papers (1, 2, 3, 4, 5) * Second dog infected with SARS-CoV-2 (ProMedMail) * Italian site with infographic in English * Image by Michele Banks * Letters read on TWiV 593 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Ori Lieberman
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Links for this episode * Scary modeling (Imperial College London) * Avigan vs SARS-CoV-2 (NHK) * SARS-CoV-2 mRNA vaccine (Clinical Trials) * SARS-CoV-2 stability (NEJM) * Pediatric COVID-19 (one, two) * SARS-CoV-2 asymptomatic infection (one, two) * CDC data on SARS-CoV-2 CFR (MMWR) * Hydroxycholorquine trial for COVID-19 (Mediterranee-infection) * Macaque SARS-CoV-2 immunity (bioRxiv) * Image by Michele Banks * Letters read on TWiV 591 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic.
Hosts: Vincent Racaniello
Guest: Stephen Morse
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Intro music is by Ronald Jenkees.
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Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school.
Hosts: Vincent Racaniello
Guest: Ori Lieberman
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Intro music is by Ronald Jenkees.
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Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Ralph Baric
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Links for this episode * Aerosol and surface stability of SARS-CoV-2 (medRxiv) * Clinical course and risk factors for COVID-19 (Lancet, pdf) * Face mask use during SARS-CoV outbreak (EID) * COVID-19 and Italy (Lancet) * Letters read on TWiV 591 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Links for this episode * Stanley Perlman answers CoV questions (Boston Globe) * Fist bump (Am J Infect Control) * Joint WHO-China report (pdf) * Second coronavirus (LA Times) * Response to second coronavirus (virological.org) * COVID-19 animal models (STAT) * Clinical predictors of COVID-19 mortality (Inten Care Med) * CoV by the numbers (NY Times) * Contamination of bar soaps (Microbios) * SARS-CoV-2 vaccine timeline (NPR) * How new vaccines are developed (GSK) * SARS among critical care nurses (Emerg Inf Dis) * How churches prevent SARS-CoV-2 spread (NPR) * Image credit * Letters read on TWiV 590 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy.
Host: Vincent Racaniello
Guests: Daniel Griffin and Valeria Cagno
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Intro music is by Ronald Jenkees.
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Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more.
Hosts: Vincent Racaniello and Rich Condit
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Links for this episode * WHO CoV sitreps * How to Prepare for the Coronavirus (NY Times) * Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf) * Cruise ship a/c could promote virus spread (Purdue news) * Image credit * Letters read on TWiV 589 * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episode * WHO CoV sitreps * Epidemiology of COVID-19 (China CDC) * COVID-19 incubation period (J Med Virol) * China clinical trials for COVID-19 (Nature) * Furin cleavage site in SARS-CoV-2 spike (virology blog) * Proximal origin of SARS-CoV-2 (Virological) * Pangolin photos (Nat Geo) * Letters read on TWiV 588 * Timestamps by Jolene. Thanks!
Weekly Science Picks Kathy - The deep sea
Rich - World's oldest message in a bottle
Dickson - Coronavirus: A visual guide
Vincent - Recent NSABB meeting Videocasts Day 1 Day 2
Listener Picks Stephen - This podcast will kill you
Neva - China's surveillance
Sophia - WHO online courses
Intro music is by Ronald Jenkees.
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Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks.
Hosts: Vincent Racaniello and Rich Condit
Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver
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Links for this episode * Measles virus vectored chikungunya vaccine (J Inf Dis) * World Reference Center for Emerging Viruses and Arboviruses * Insect-specific alphavirus vaccine vector (Nat Med) * Legacy of arbovirus hunters (Viruses) * Electron microscopy for novel arboviruses (Viruses) * Sylvatic dengue (Am J Trop Med Hyg) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne
Download TWiV 586 (72 MB .mp3, 119 min)
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Links for this episode * China reacted too slowly to epidemic (NY Times) * Wuhan rounds up infected (NY Times) * 2019-nCoV asymptomatic transmission report flawed (Science) * Mucus reduces effectiveness of alcohol gels (mSphere) * SARS-CoV in feces (NEJM, Gastroenterology) * Inadequate plumbing and spread of SARS-CoV (WHO) * Persistence of virus on surfaces (one, two, three, four) * Letters read on TWiV 586 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Mutation, Adaptation, and Virus Genomes
Alan - The Comet
Rich - Finding Your Roots: Science Pioneers
Dickson - Let’s Fill Our Cities With Taller, Wooden Buildings
Vincent - Twenty-first century plague by Thomas Abraham
Listener Pick Mark - Tracking CoV infections
Sophia - Legislative approaches to immunization
Intro music is by Ronald Jenkees.
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The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * ASV 2020 * Real time tracking of 2019-nCoV (JHU) * Estimation of 2019-nCoV R0 (Int J Inf Dis) * WHO Sitreps on 2019-nCoV * Coronavirus overtakes SARS (SCMP) * HHS press conference * Discovery of 2019-nCoV (bioRxiv) * Rich CoV genes in bats (PLoS Path) * Early 2019-nCoV transmission dynamics (NEJM) * Clinical features of early 2019-nCoV patients (Lancet) * Remdesvir for MERS-CoV (Nat Commun) * Transmissibility of 2019-nCoV (Imperial Coll, pdf) * Comparison of R0 of pathogens (Guardian) * Forecast of 2019-nCoV (WHO, Univ Hong Kong, pdf) * Quammen on 2019-nCoV (NY Times) * Benefits of handwashing (NY Times) * Asymptomatic 2019-CoV transmission (NEJM) * Summary of TWiV 584 * Surgical vs N95 masks (JAMA) * Letters read on TWiV 585 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Pandemic
Alan - Educated by Tara Westover
Rich - Star Trek: Picard
Dickson - Highest Resolution Image Ever Taken of Surface of the Sun
Kathy - Scientists make vampire bats ‘glow’ to simulate vaccine spread
Vincent - Virology Lectures 2020
Listener Pick Edward - Virus snowflake designs
Anthony - Microbe Hunting Autism to Zika
Intro music is by Ronald Jenkees.
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Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler
Guest: Ralph Baric
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Links for this episode * ASV 2020 * WHO coronavirus sitreps * CIDRAP article on coronavirus vaccines * Phylogenetic analysis of 2019-nCoV * ACE2 is 2019-nCoV receptor (bioRxiv) * Visual explainer of Huanan market (SCMP) * Clinical features of 2019-nCoV patients (Lancet) * Familial cluster of pneumonia caused by 2019-nCoV (Lancet) * SARS-CoV 29 nt deletion reduces replication (Sci Rep) * NSABB * 2019 TWiV World Tour t-shirt * Letters read on TWiV 584 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Library plug-in for Firefox or Chrome
Rich - Sounds of the Solar Wind (Parker Solar Probe)
Dickson - Stunning wildlife photos
Kathy - Incomplete list of things that blow the minds of intro bio students
Vincent - Mosquito photographs by Alex Wild (and anti-pick)
Listener Pick Justin - YadaYadaYada virus
Intro music is by Ronald Jenkees.
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Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters.
Hosts: Vincent Racaniello and Rich Condit
Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh
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Intro music is by Ronald Jenkees.
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TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker Download TWiV 582 (71 MB .mp3, 118 min)
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Links for this episode * ASV 2020 * NJ ready to remove religious vaccine exemptions (Patch) * New virus causing pneumonia in China (NY Times) * New China virus is coronavirus (NY Times, ProMedMail) * Weekly influenza cases (CDC) * Future of influenza vaccines (Vaccines) * Household influenza vaccine study (Int J Epidemiol) * African swine fever (USDA) * African swine fever infographics (one, two) * Race for African swine fever vaccine (Scientist) * 3D structure of African swine fever virus (J Biol Chem) * Letters read on TWiV 582 * Timestamps by Jolene. Thanks!
Weekly Science Picks Rich - Mayo Clinic - Ken Burns; Patient Care and Health Information
Dickson - Australia Fires; Insect ecology; Smoke and aerosols
Kathy - runcible
Vincent - Without a Vaccine, These Are Your Odds
Intro music is by Ronald Jenkees.
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For the first TWiV of 2020 we reveal that microbiome depletion with antibiotics alters the immune response to influenza vaccine, and how successive blood meals facilitate virus dissemination in mosquitoes and transmission potential.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * ASV 2020 * Vaccines are safe and effective (Science) * Microbiome perturbation alters response to flu vaccine (Cell) * Successive blood meals aid virus dissemination in mosquitoes (Nat Micro) * Letters read on TWiV 581 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Retrovirus cookie cutter! (and Phage, Adenovirus, Rabies virus, and Antibody
Alan - “Yah! Yah! Yah!” by Jack London, and the true story it’s based on
Dickson - Why whales are big but not bigger
Kathy - Dual Axis Illusion
Vincent - The Fall of the Faculty by Benjamin Ginsberg
Listener Pick Suellen - Patient Zero podcast
Intro music is by Ronald Jenkees.
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From the University of Texas at Austin, Vincent and Rich speak with Chris Sullivan about his work on miRNAs encoded in the genomes of polyomaviruses and papillomaviruses, and how an RNA triphosphatase restricts hepatitis C virus replication.
Hosts: Vincent Racaniello and Rich Condit
Guest: Chris Sullivan
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Links for this episode * Sullivan lab * Virus-encoded miRNAs in papillomaviruses (PLoS Path) * Murine polyomavirus miRNA promotes viruria (J Virol) * DUSP11 helps XRN restrict hepatitis C virus (PNAS) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases.
Host: Vincent Racaniello
Guests: Dave AuCoin, Cyprian Rossetto, Claudia Rückert, and Subhash Verma
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Links for this episode * PAN's labyrinth (Viruses) * KSHV SOX protein DNAse activity (J Virol) * Vertical flow immunoassay for pathogen detection (Talanta) * Small RNA responses of mosquitoes (Insect Biochem Mol Biol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available.
Host: Vincent Racaniello
Guests: Kartik Chandran, Zachary Bornholdt, Steven Bradfute, John Dye, Matthias Forsell, Jason McLellan, Laura Walker, and Cecelia Vial.
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Links for this episode * NIH U19 grant mechanism * $22 million Prometheus grant * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization.
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Links for this episode * Unité de Virologie Structurale * Tick-borne encephalitis glycoprotein structure (Nature) * HCV RNA polymerase structure (PNAS) * Flavivirus structural heterogeneity (Curr Op Viral) * Antibody responses to flaviviruses (EMBO Rep) * Covalently linked dengue envelope dimers (Nat Comm) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health.
Host: Vincent Racaniello
Guests: Thea Kølsen Fischer, Kim Benschop, Caroline Brown, Heli Harvala, and Irma Salimovic-Besic
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Links for this episode * 22nd ESCV meeting * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate.
Hosts: Vincent Racaniello, Rich Condit, and Nels Elde
Guests: Assaf Vardi, Stephen Wilhelm, and Alexandra Worden
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Links for this episode * 4th Ringberg Symposium on Giant Virus Biology * In-plaque mass spectrometry imaging (Nature Micro) * Infection by brown tide virus, AaV (Front Micro) * Choano virus with a rhodopsin photosystem (PNAS) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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From Georgia State, Vincent speaks with economics professor Paula Stephan about the ways science is supported in the US, how universities offload risks, the absence of risk-taking, and much more.
Hosts: Vincent Racaniello
Guest: Paula Stephan
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Links for this episode * How Economics Shapes Science * Coalition for Next Generation Life Science * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of 'virus' and the contribution of phage research to the study of animal viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: William Summers
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Links for this episode * Bill’s ASV 2019 talk (PPT download) * Inventing viruses (Ann Rev Virol) * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Restoration of Western Flyer
Rich - Purification of phage T7 RNA polymerase
Dickson - The Galaxy is Not Flat
Bill - Efficacy of tetravalent dengue vaccine
Vincent - Blowout by Rachel Maddow
Intro music is by Ronald Jenkees.
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Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Amy Rosenfeld
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Links for this episode * EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) * Enterovirus antibodies in CSF of AFM patients (mBio) * Serology implicates enteroviruses in AFM (Nat Med) * EV-D68 neurotropism is not new (mBio) * Letters read on TWiV 572 * Timestamps by Jolene. Thanks!
Weekly Science Picks Amy - Enterovirus biology and pathogenesis and Acute Flaccid Myelitis Association
Rich - Tesla
Dickson - Nikon Small World 2019 Photo Competition
Kathy - Term limits in academic leadership #1 and #2
Vincent - Coywolf: New hybrid carnivore
Listener Picks Anonymous - Spill the Beans vaccinated shirts
Intro music is by Ronald Jenkees.
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The League of Extraordinary Virologists celebrate the eradication of wild poliovirus type 3, and consider the effectiveness of an influenza vaccine produced in insect cells, and how small RNAs are protecting the Koala germline from retroviral invasion.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Flublok (CDC) * Adjuvant study of flu vaccines (NIH) * Immunogenicity of quadrivalent Flublok (J Inf Dis) * Monoclonal antibody response to Flublok (J Virol) * Current flu vaccine recommendations (CDC) * Double dose flu vaccine immunogenicity (Hum Vac Immunother) * piRNA response on retroviral invasion of Koala genome (Cell) * piRNAs rise to rescue Koalas (Cell) * Image credit * Letters read on TWiV 571 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - The Machinery of Life by David Goodsell
Alan - Pomological watercolors
Dickson - Wildlife Photographer of the Year
Kathy - DiversifyMicrobiology DiversifyImmunology and Marmot becomes fox food
Vincent - Burnet A Life by Christopher Sexton
Listener Picks Justin - Worm with three sexes
Intro music is by Ronald Jenkees.
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At Aarhus University in Denmark, Vincent speaks with Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte about their careers and their work on sensing herpesviral DNA, immunodeficiencies that predispose to severe viral infections, and the path to a cure for HIV/AIDS.
Hosts: Vincent Racaniello
Guests: Trine Mogensen, Søren Paludan, Ole Søgaard, and Madalina Carter-Timofte
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Links for this episode * Aarhus University * Findaphd.com * Sensing incoming HSV-1 (J Int Cyto Res) * Be careful of canons (TWiV 456) * Polio and host genetics (Front Micro) * TLR9 treatment of AIDS (AIDS) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiV pro-vaxxers reveal viruses that infect endangered wild salmon, and how iron in host serum modulates dengue virus acquisition by mosquitoes.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episode * New viruses that infect endangered wild salmon (eLife) * Host serum iron modulates dengue virus acquisition by mosquitoes (Nat Micro) * Image credit * Letters read on TWiV 569 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Retraction of new CCR5/lifespan study
Alan - Nomad Press illustrated science books, and illustrator Lex Cornell
Dickson - RARE: Creatures of the Photo Ark
Vincent - The Odyssey of Eradication by Thomas Abraham
Listener Picks Justin - Mass spec pen
Mark - What really brought down the Boeing 737 Max?
Intro music is by Ronald Jenkees.
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In the second episode from the Karolinska Institute in Stockholm, Vincent speaks with Jan Albert, Petter Brodin, and Anna Smed-Sörensen about their work on enterovirus D68, systems immunology, and human pulmonary viral infection and inflammation. Hosts: Vincent Racaniello
Guests: Jan Albert, Petter Brodin, and Anna Smed-Sörensen
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Links for this episode * Karolinska Huddinge * Evolution of enterovirus D68 (Virus Evol) * Maternal anti-viral antibodies in newborns (Nat Med) * Respiratory phagocytes in human influenza (Front Immunol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Poliomyelitis returns to the Philippines (Mashable, virology blog) * EEE in the USA (Am J Trop Med Hyg) * Chemokine helps HIV-1 release (eLIFE) * Image credit * Letters read on TWiV 567 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - History of infectious disease before/after vaccines
Alan - NIH Ham Radio Club
Rich - Renewable jet fuel from air
Dickson - Newly Discovered Comet Is Likely Interstellar Visitor
Kathy - How professors spend their time
Vincent - Non-polio enterovirus surveillance network
Listener Picks Alexey - Periodic Table Podcasts and Videos
Intro music is by Ronald Jenkees.
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The TWiV team reveals the protein corona that surrounds virus particles and influences infectivity and amyloid aggregation, and a proofreading-impaired herpesvirus that produces quasispecies-like populations.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guest: Kiki Warren
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Links for this episode * Human fetal tissue research restrictions (The Scientist) * Viral protein corona (Nat Commun) * Proofreading-impaired herpesvirus (Nat Micro) * Phage quasispecies (Cell) * Letters read on TWiV 566 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Astronomy photographer of the year
Rich- Urban living leads to high cholesterol... in crows
Kiki- Reversal of epigenetic aging
Vincent- General Virology by SE Luria
Listener Picks Sindhu - Sweden Solar System
Anthony- Surprising role of viruses in evolution with Eugene Koonin
Paul- The Obscure Virus Club
Intro music is by Ronald Jenkees.
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From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses.
Hosts: Vincent Racaniello
Guests: Niklas Björkström, Ali Mirazimi, and Matti Sällberg
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Links for this episode * Karolinska Huddinge * CCHV experimental vaccines (J Virol) * Increased NK function after antiviral cessation (J Inf Dis) * Impact of HCV infection on NK cell repertoire (Nat Comm) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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From the 16th Smögen Summer Symposium on Virology, Vincent speaks with Erling Norrby about how he has used archival material to provide insight into early Nobel Prizes for research on viruses.
Hosts: Vincent Racaniello
Guest: Erling Norrby
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Links for this episode * Swedish Society for Virology * Nobel Prizes and Life Sciences by Erling Norrby * Nobel Prizes and Nature's Surprises by Erling Norrby * Nobel Prizes and Notable Discoveries by Erling Norrby * Nobel Prizes: Cancer, Vision and the Genetic Code by Erling Norrby * Polio and Nobel Prizes (Ann Neurol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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David Tuller returns to talk about his efforts of the past year to expose the methodological and ethical problems with the PACE and Lightning trials for therapy of ME/CFS.
Host: Vincent Racaniello
Guest: David Tuller
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Intro music is by Ronald Jenkees.
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The TWiVologists consider whether to receive an influenza vaccine in August (in the northern hemisphere), and mice implanted with human lung fragments for studying microbial pathogens.
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Waning of influenza vaccine protection (Clin Inf Dis) * Precision mouse models for microbial pathogenesis (Nat Biotech) * Letters read on TWiV 563 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Why we need to increase diversity in the immunology research community
Alan - Stock photos of vaccination that don’t suck
Kathy- Sample size calculator
Vincent- How Economics Shapes Science by Paula Stephan
Listener Picks Melinda - Zome Tools
Intro music is by Ronald Jenkees.
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TWiV travels to Rutgers University to speak with Brad, Kay, Siobain, and Kim about their careers and their work on viruses of plants, fungi, bacteria, diatoms, and coccolithophores.
Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker
Guests: Brad Hillman, Kay Bidle, Siobain Duffy, and Kim Thamatrakoln
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Links for this episode * Viruses of plant-interacting fungi (Adv Virus Res) * Why are RNA virus mutation rates so damn high? (PLoS Biol) * CRESS viruses (Adv Virus Res) * Coccolithovirus facilitation of carbon export in North Atlantic (Nat Micro) * Silicon limitation facilitates virus infection of marine diatoms (Nat Micro) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection.
Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker
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Links for this episode * Two new and effective Ebolavirus treatments (NIH, Nature) * A virus in a fungus in a plant (Science) * Dampened NLRP3-mediated inflammation in bats (Nat Micro) * Bat tolerance to virus infection (Nat Micro) * Image credit * Letters read on TWiV 561 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Deaf student makes sign language terms to communicate science
Alan - Show Your Stripes
Vincent- Sixty Years of Discovery
Listener Picks Eric - This drug could end HIV - why hasn't it?
Intro music is by Ronald Jenkees.
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From the meeting of the Centers of Excellence for Influenza Research and Surveillance, Vincent speaks with Alan, Florian and Jennifer about their careers, the purpose of CEIRS, universal influenza vaccines, and cellular responses to infection in pediatric populations.
Host: Vincent Racaniello
Guests: Alan Embry, Florian Krammer, and Jennifer Nayak
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Links for this episode * NIAID CEIRS * 12th CEIRS meeting summary (pdf) * Antibody response to influenza virus (Nat Rev Micro) * Influenza virus CD4 T cells in children and young adults (Sci Rep) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The complete TWiV team give a report on the Ebola virus outbreak in DRC, and reveal that cell surface nectin proteins cause the transfer of cytoplasmic cargo, including measles virus, between cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Fire Alarm at ASV * Ebola outbreak sitrep(WHO) * Ebola outbreak dashboard(WHO) * Ebola outbreakDRC (MSF) * Ebola articles at CIDRAP * Ebola virus vaccine could run out(STAT news) * Nectin mediated cytoplasmic transfer(J Cell Sci) * Letters readon TWiV 559 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - DukeMed Distinguished Award: Bill Joklik
Alan - Audubon photography awards for 2019
Rich - Joklik paper on vaccinia virus mRNA; Joklik MEM
Dickson- Ghost orchid pollination revealed
Kathy- Crocheted petri plates
Vincent- Documents relating to history of ASV
Listener Picks Neva - What happens if we engineer a superbug?
Intro music is by Ronald Jenkees.
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From ASV 2019 at the University of Minnesota, TWiV explores the origins of the American Society for Virology with Sid Grossberg and Pat Spear.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Sid Grossberg and Pat Spear
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Links for this episode * American Society for Virology * Bill Joklik, 92 * How ASV was founded (Virology) * Signatures at the Chicago meeting (page one, page two) * Timeline history of ASV (jpg) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic.
Hosts: Vincent Racanielloand Ben Berkhout
Guests: Ron Fouchier, Rosina Girones, and Marie-Paule Kieny
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Links for this episode * ECV2019 * Drift of human H2N2 viruses (J Viral) * Viruses in urban sewage (Sci Tot Environ) * Ebola virus vaccine efficacy (Lancet) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Deficits in children born to Zika virus infected mothers (Nat Med) * Zika virus is still a threat (NY Times) * N-glycolyl-neuraminic acid as influenza virus receptor (Cell Rep) * Letters read on TWiV 556 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Foldable viral capsid models and Foldable models demonstrate T numbers
Alan - Laws Guide to Nature Drawing and Journaling
Dickson- NASA 50th Events
Kathy- Alta Obscura’s 17,069 strange and wonderful places
Vincent- TWiEVO 44: The enemy of my enemy is my phage
Listener Picks Anthony - Global Water Pathogen Project
Intro music is by Ronald Jenkees.
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From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology.
Hosts: Vincent Racaniello, Brianne Barker, and Calvin Yeager
Guest: Craig Cameron
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Links for this episode * Cameron laboratory * Curioscity podcast * Ribavirin is an RNA virus mutagen (Nat Med) * RNA virus error catastrophe: test using ribavirin (PNAS) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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A trio TWiVers reports on influenza in Australia, how a host protein impacts bird to human movement of influenza virus, and marine DNA viral diversity in the oceans from pole to pole.
Hosts: Vincent Racaniello, Kathy Spindler, and Alan Dove
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Links for this episode * Australian Influenza Surveillance * Real-time tracking of influenza H3N2 * ANP32B, or not to be (eLife) * ANP32B on TWiV 377 * Species specific differences in ANP32B for influenza virus replication (eLife) * Marine viral DNA diversity pole to pole (Cell) * Letters read on TWiV 554 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Stephanie Langel’s Discovery Talk
Kathy- Map of languages in the USA
Vincent- Grad student mental health with Susanna Harris video and on TWiM 199
Listener Picks Fernando - Pushing back on hyped-up science
Intro music is by Ronald Jenkees.
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Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story, about the history of poliovirus vaccines.
Host: Vincent Racaniello
Guest: David Oshinsky
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Intro music is by Ronald Jenkees.
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Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Kiki Warren
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Links for this episode * Bacteriophage DNA polymerase is primer-independent (PNAS) * Primer-independent DNA polymerase from mobile elements (Cell Rep) * Non-HBV helper viruses for HDV (Nat Comm) * Waning of measles vaccine immunity (one, two, three) * Letters read on TWiV 552 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Seek
Rich - Want to See My Genes? Get a Warrant and NIH director will no longer speak on all-male science panels
Brianne- Unique scientists
Dickson- Vaccines - Calling the Shots
Vincent- NY eliminates religious vaccine exemptions and Jessica Biel reveals that she does not understand vaccines
Kiki- Converting type A to type O blood
Listener Picks Justin - An Apple a Day
Intro music is by Ronald Jenkees.
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At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim.
Host: Vincent Racaniello
Guests: Bryan Cullen, Paul Bieniasz, Michael Malim, and Ann Skalka
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Intro music is by Ronald Jenkees.
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TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes.
Hosts: Vincent Racaniello, Dickson Despommier,Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Neuronal cell line supports herpes simplex virus latency (J Virol) * Protect, modify, deprotect (PNAS) * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Quabbin Reservoir
Rich - Katherine Swan Ginsburg Humanism in Medicine Program; The Arnold P. Gold Foundation
Brianne- UPitt Measles Simulator
Dickson- James Webb Space Telescope
Vincent- Nobel Prizes and Life Sciences by Erling Norrby
Intro music is by Ronald Jenkees.
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Kartik and Rohit join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Kartik Chandran and Rohit Jangra
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Links for this episode * Einstein goes viral (TWiV 314) * Michael Rossmann, 88 (virology blog) * Protocadherin-1 essential for New World hantavirus entry (Nature) * Image credit * Timestamps by Jolene. Thanks!
This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details.
Weekly Science Picks Alan - Temi and Trint
Rich - Using Jupiter's moons to determine where on Earth you are
Kathy- Best architecture in every state
Vincent - Cyberwire Podcast: The Ghost and the Mole
Kartik- Slack
Rohit- Antibody responses to viral infections
Intro music is by Ronald Jenkees.
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Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses.
Hosts: Vincent Racanielloand Marion Koopmans
Guests: Martin Beer, Stephan Gunther, and Vera Ros
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Links for this episode * ECV2019 * Partnerships not parachutes (TWiV 413) * Fatal Borna disease virus infection in transplant recipients (NEJM) * Sequencing of 2018 Lassa virus outbreak (Science) * Zombie caterpillar behavior (Parasitol) * Timestamps by Jolene. Thanks!
This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details.
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses.
Host: Vincent Racaniello
Guests: Cara Pager, Rachel Netzband, and Alex Ciota
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Links for this episode * Five postdocs in North America (TWiV 194) * Zika virus subverts stress granules (J Virol) * DDX68 modulates miR-122 interaction with HCV RNA (Virol) * (+) RNA virus epitranscriptome (Nucl Acids Res) * Adaptation of Rabensburg virus to vertebrate hosts (Virol) * Effects of Zika virus strain and Aedes species on vector competence (Emerg Inf Dis) * Inter- and intra-host genetic variation of West Nile virus and fine-scale evolutionary pressures (Infect Genet Evol) * Timestamps by Jolene. Thanks!
This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.comfor more details.
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The un-encapsidated TWiV Humans discuss finding hepatitis D virus-related sequences in birds and snakes, and fatal swine acute diarrhoea syndrome caused by a coronavirus of bat origin.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * European Virus Archive * ASV early bird registrationends 15 May * FDA approves Dengvaxia * Divergent hepatitis D-like agentin birds(Viruses) * Novel deltavirus in snakes(mBio) * SADS-coronavirusin piglets (Nature) * Hosts and sources of endemic human coronaviruses(Adv Virus Res) * Image credit * Letters readon TWiV 546 * Timestamps by Jolene. Thanks!
This episode is sponsored by the 2019 Chem/Bio Defense Science and Technology Conference. Are you working on innovative research that can shape the future of chemical or biological defense? Submit your abstract and present your work to more than 1,500 leaders from government, academia and industry. Visit www.cbdstconference.com for more details.
Weekly Science Picks Alan - Plots of Data visualization tool
Rich - How to control the brain; Meet UF Physician Kelly Foote, MD
Dickson- Oceanix
Kathy- Iceproofing large structures
Vincent - Neanderthal Man: In Search of Lost Genomes by Svante Paabo
Listener Pick Johyne- NYTimes Mag Lab (sorry, no link)
Sheena - History of Vaccines by NPR
Intro music is by Ronald Jenkees.
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Jens Kuhn returns to TWiV to explain Select Agents, Priority Pathogens, Australia List Pathogens, Risk Group Agents, biosafety, biosecurity, and biosurety.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
Guest: Jens Kuhn
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Links for this episode * Bioweapon (TWiV 508) * Bioterrorism and Biocrimes by W. Seth Carus * Select Agents (selectagents.gov) * BMBL Manual 5th Edition (pdf) * Threading the NEIDL video (YouTube) * Timestamps by Jolene. Thanks!
Weekly Science Picks Jens - Forvo pronunciation guide
Brianne -How long do vaccines last?
Alan- How much hotter is your home town than when you were born?
Dickson- 50 Stunning Photos of Earth
Vincent - Madness and Memory by Stanley Prusiner
Intro music is by Ronald Jenkees.
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The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Maternal anti-viral antibodies in newborns (Nat Med) * Complement protein blocks adenovirus uncoating (Cell Host Micr) * Antibodies neutralize virus inside cells (virology blog) * Image credit * Letters read on TWiV 544 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Doctors use HIV in gene therapy to fix 'bubble boy' disease
Rich - I Want What My Male Colleague Has
Kathy- Preventing airborne disease (video and primary article)
Vincent - The Mueller Report
Listener Pick Steve- Vaccine Mythbusting
Cyprian- Ten simple rules towards healthier research labs
Intro music is by Ronald Jenkees.
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The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Medusavirus (J Virol) * Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) * Image credit * Letters read on TWiV 543 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - How to Take a Picture of a Black Hole
Alan- Jupiter Marbleimage
Rich - NASA Commercial Crew Program; How SpaceX and Boeing will get Astronauts to the ISS; Everyday Astronaut
Dickson- Sky-High Stunners
Kathy- Arts at Michigan photo winnersand UM Microscopy Core image contest winners
Vincent - NYC declares emergency over measles outbreak, mandates vaccinations and EMDataResource
Listener Pick Martin- Sydney Brenner passes
Intro music is by Ronald Jenkees.
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Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases.
Host: Vincent Racaniello
Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein
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Links for this episode * Microbiotix, Inc. * MBX-400 * Microbiotix pipeline * Microbiotix publications * Timestamps by Jolene. Thanks!
Listener Pick Islam- How to successfully collaborate with industry
Intro music is by Ronald Jenkees.
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The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episode * Evidence for plant mitoviruses (Virology) * Uncoating of quasi-enveloped HAV (eLife) * Image credit * Letters read on TWiV 541 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan- Where and when to see cherry blossoms
Dickson- Nebraska floods
Kathy- Peeps fungal infection experiment
Vincent - Emergency declared in NY over measles, unvaccinated barred from public spaces
Listener Pick Sam- STLR conversations
Josh- Tree of Life
Intro music is by Ronald Jenkees.
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The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Kathy Spindler
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Links for this episode * Diversity of HSV2 in neonates (mSphere) * Adaptation of rabbits to myxoma virus (Science) * Principal component analysis (YouTube) * Image credit * Letters read on TWiV 540 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan- The Quarters
Rich- Brian May - New Horizons (Ultima Thule Mix) [Official Music Video]
Dickson- How rats became an inescapable part of city living
Kathy- Principal Component Analysis (short longer) and Educational Material about Influenza Viruses
Vincent - Why “chickenpox parties” are a terrible idea—in case it’s not obvious
Intro music is by Ronald Jenkees.
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The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Paul Has Measles now in German (virology blog) * Chloroviruses lure hosts (J Virol) * Multicellular replication in plants (eLife) * Image credit * Letters read on TWiV 539 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Why Do So Many Scientists Want to be Filmmakers
Alan- Better boarding method airlines won’t use
Dickson- Mass timber building
Kathy- What organisms to study flow chart
Vincent - World Pulls Andon Cord on 737 MAX
Listener Pick Richard- The Real Cost of Knowledge
Islam- 200 icosahedral viruses poster
Mike- Post-Doc Me Now
Intro music is by Ronald Jenkees.
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TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Wendy Mauryand Stanley Perlman
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Links for this episode * TIM-1 is receptorfor Ebolaviruses (Proc Natl Acad Sci) * TIM-1 is receptor for Lassa virus (J Virol) * SARS coronavirus causes neuronal death (J Virol) * T cells and IL-10 in viral demyelination (J Neuroimmunol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * European Congress of Virology 2019 * ASM Clinical Virology Symposium * Intel ISEF judges needed * Roald Dahl endorses measles vaccine * Viruses encode ribosomal proteins (Nat Commun) * Bat influenza virus receptor (Nature) * Going to bat for flu research (TWiV 173) * Letters read on TWiV 537 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Yes, I'm a Scientist on Twitter. Stop Judging Me.
Alan- Impact of vaccines, graphed in heat maps
Dickson- Treehoppers
Kathy- World watershed maps
Rich- Gene Machine by Venki Ramakrishnan
Vincent - House hearing on measles outbreak (ASM comment)
Listener Pick Jordan- Facebook may remove anti-vaccine recommendations
Intro music is by Ronald Jenkees.
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Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals.
Hosts: Vincent Racaniello and Alan Dove
Guests: Jonathan Runstadler, Nichola Hill, Wendy Puryear, and Kate Sawatzki
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Links for this episode * Cummings School of Veterinary Medicine * Influenza virus in North Atlantic grey seals (Emerg Microbes infect) * Influenza viruses in Alaskan wild birds (Emerg Inf Dis) * Wild bird influenza virus replication in human cells (Infect Genet Evol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode * European Congress of Virology 2019 * ASM Clinical Virology Symposium * Intel ISEF judges needed * Quantum dots to visualize influenza entry (PNAS) * Quantum dots (Wikipedia) * Flavivirus NS1 triggers endothelial dysfunction (Cell Rep) * Image credit * Letters read on TWiV 535 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Hotel Influenza
Alan- Your town’s climate in 60 years
Dickson- BMC Research in Progress Photo Competition
Rich- NASA's Opportunity Rover Mission on Mars Ends (landing animation)
Vincent - Watch a single cell become a complex organism in six minutes
Listener Pick Anne- Pathogenesis II Kickstarter
Intro music is by Ronald Jenkees.
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The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA.
Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker
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Links for this episode * European Congress of Virology 2019 * ASM Clinical Virology Symposium * Intel ISEF judges needed * Calicivirus portal visualized (Nature) * Calicivirus portal - long version (biorXiv) * m6A modification and innate response (Nat Immunol) * Brianne Barker's immunology course * m6A modification and innate response (Genes Dev) * Letters read on TWiV 534 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - The Red Queen's Race Card Game
Alan- Pentax Papilio II
Dickson- Felice Frankel on improving visual side of science
Kathy- History of the alphabet chart (free download) usefulcharts.com (see blog, such as Latin Greek Cyrillic Venn Diagram)
Vincent - Virology Lectures 2019
Listener Pick Peter- Microbehunter (YouTube, blog, forum)
Intro music is by Ronald Jenkees.
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The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China.
Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * ASV 2019 * European Congress of Virology 2019 * ASM Clinical Virology Symposium * Intel ISEF judges needed * Jerard Hurwitz age 90 RIP * Paul has Measles now in French (virology blog) * Chinese plasma virome (Cell) * Blood virome of 8000 humans (TWiV 435) * Měnglà filovirus from bats in China (Nat Microbiol) * How to write a virus name (ICTV) * Ortervirales (J Virol) * Virologists oppose new definition of virus species (Arch Virol) * Ebola sitrep (WHO) * Letters read on TWiV 533 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Trying Polar Vortex Experiments at Home
Rich- Three Identical Strangers
Kathy- Science wear, especially for Valentine’s Day (discount)
Vincent - State of anti-vaccine movement in US and Top 10 Health Threats for 2019
Listener Pick Amy- If government can't deliver safe vaccines, is it fit to rule?
Ted- Understanding Economics of Microbial Threats (pdf)
Intro music is by Ronald Jenkees.
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The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Please take the TWiV listener survey * ASV 2019 * European Congress of Virology 2019 * ASM Clinical Virology Symposium * Intel ISEF judges needed * ASV in Poland does not let go (Ag Buiten ) * Alarming ASF outbreak (Science) * African swine fever (Euro Comm) * African swine fever review (Vet J) * ASF in wild boar (EFSA J) * ASF in Belgian wild boar (Dept Env Food Rural Aff) * Handbook on ASF in wild boar (Stand Grp Experts) * Feral hogs (VA DGIF) * Nonhuman morbillivirus with zoonotic potential (J Virol) * Letters read on TWiV 532 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Retraction Watch database
Rich- “The Mayo Clinic: Faith Hope Science” by Ken Burns
Kathy- U-M EEB Photographer at Large contest
Vincent - Vaccines: An achievement of civilization
Listener Pick David- Useless Knowledge Begets New Horizons
Intro music is by Ronald Jenkees.
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Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Patrick Moore
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Links for this episode * Please take the TWiV listener survey * ASV 2019 * European Congress of Virology 2019 * ASM Clinical Virology Symposium * Intel ISEF judges needed * Cancer virology at Pitt * Alice Huang’s DI particles (PubMed) * Circular DNA tumor viruses make circular RNAs (PNAS) * Backsplice * Image credit * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne – The herd to the rescue
Alan – Magic Wings Butterfly Conservatory
Dickson – 100,000 Genomes Project
Kathy – Your Age on Other Worlds
Vincent – Vitamin D and Prevention of Cancer and Cardiovascular Disease
Pat – North Korea and Bioweapons
Listener Pick Eric – The Molecular Basis of Life
Intro music is by Ronald Jenkees.
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Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Steve Goff
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🎼 They’ll histone you when you start to transcribe,
And they’ll histone you just for tryin’ to get by,
So be careful when you uncoat your genome,
‘Cause everybody must histone.
Links for this episode * Please take the TWiV listener survey * ASV 2019 * European Congress of Virology 2019 * Histones loaded onto incoming retroviral DNA (Cell Host Micr) * NP220 and silencing of incoming retroviral DNA (Nature) * HIV-1 and HUSH (TWiV 516) * TWiV World Tour 2018 t-shirt * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - The Tangled Tree by David Quammen
Dickson- Ammonia could power the globe
Kathy- Portmanteaux and A.Word.A.Day
Vincent - Curioscity
Steve- Alice and Bob Meet the Wall of Fire
Listener Pick Chaim- Tony Fauci on getting your flu vaccine (mp3)
Intro music is by Ronald Jenkees.
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At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager.
Host: Vincent Racaniello
Guest: Roland R. Rueckert
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Links for this episode * Video of this episode (YouTube) * Roland's first paper (Anesthesiol) * Purification of phiX174 (Virology) * Studies on viral structure (Virology) * Automated gel fractionator (Anal Bioch) * Picornaviral gene order (J Virol) * Picornavirus protease discovery (J Virol) * Poliovirus processing map (J Virol) * Nomenclature of picornavirus proteins (J Virol) * Black beetle virus (J Virol) * Rhinovirus crystallization (PNAS) * Mapping mAb binding sites (J Virol) * Replication of animal virus in yeast (PNAS) * Roland's last paper (J Virol) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Please take the TWiV listener survey * ASV 2019 Satellite Symposia * Crowdfunding for EV-D68 research * TWiV World Tour 2018 t-shirt (Amazon) * Cool virology from 2018 + Viruses behind AD? TWiV 505, TWiV 519, clinical trial one and two + Wolbachia-mosquito release halts dengue (TWiV 506); World Mosquito Program + Evolutionary history of RNA viruses: TWiV 491 and TWiV 526 + Horsepox as ancestral smallpox vaccine, including synthesis: TWiV 478 + Ebola continues: TWiV 494, TWiV 495, TWiV 505, TWiV 507, TWiV 515, TWiV 482 + Clues to many mysteries: TWiV 481, TWiV 484, TWiV 493, TWiV 515, TWiV 522 + Pro-vaccination: TWiV 500, TWiV 496, TWiV Special; measles in Ukraineand Europe + Outbreak influence: TWiV 501, TWiV 527, TWiV 520, TWiV 507, TWiV 504 + Insect viruses and immunity: TWiV 525, TWiV 524, TWiV 522, TWiV 495, TWiV 485, TWiV 482, TWiV 479 + Big RNA virus genomes (TWiV 509) and Giant viruses: TWiV 490, TWiV 506, TWiV 521, TWiV 484 * Letters read on TWiV 528 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Pandemic Trail game
Rich- On a Bat’s Wing and a Prayer
Dickson- Decoding Watson
Kathy- Phenotypic variation in outbred and inbred mice
Vincent - Trump County Confronts the Administration Amid Rash of Child Cancers
Listener Pick Anne- Peter Hotez interview
Islam- Letter from Crick to Watson (pdf)
Intro music is by Ronald Jenkees.
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The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Please take the TWiV listener survey * ASV 2019 Satellite Symposia * Crowdfunding for EV-D68 research * Outbreak (exhibit, TWiV 501) * Four Corners hantavirus outbreak (Wikipedia) * Death at the Corner (Atlantic) * Hantavirus infection by US state (CDC) * Hantavirus US cases and mortality (CDC) * Hantavirus international cases (CDC) * Belmont hantavirus death (NYTimes) * Intestinal dysmotility following flavivirus infection of mice (Cell) * Image credit * Letters read on TWiV 527 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Zooming into Sagittarius A, ESO video
Rich- Orbits and Ice Ages: A History of Climate
Dickson- National Geographic Best Photos 2018
Kathy- HealthMap Vaccine Finder
Vincent - Taylor Custom
Listener Pick Neal- The Yoda of Silicon Valley
Intro music is by Ronald Jenkees.
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The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler
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Links for this episode * Please take the TWiV listener survey * ASV 2019 Satellite Symposia * Crowdfunding for EV-D68 research * Aaron Klug, 1926-2018 (Nature) * Prions in sCJD eyes (mBio) * Evolution of RNA viruses (mBio) * Walter Gilbert's The RNA World (Nature) * Image credit * Letters read on TWiV 526 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - Population mountains to visualize cities
Rich- A Neanderthal Perspective on Human Origins with Svante Pääbo
Kathy- NASA Space Mission posters
Vincent - Package Thief vs Glitter Bomb Trap
Listener Pick Neal- Was a Scientist Jailed?
Intro music is by Ronald Jenkees.
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Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism.
Host: Vincent Racaniello
Guest: Peter Hotez
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Links for this episode * Peter Hotez at Baylor College of Medicine * Peter Hotez on Twitter * Vaccines Did Not Cause Rachel's Autism (Amazon) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
Guest: Michelle Flenniken
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Links for this episode * MSU Pollinator Health Center * Honeybee antiviral defenses (Sci Rep) * The buzz about honeybee viruses (PLoS Path) * Recently identified bee viruses (Curr Op Insect Sci) * Videos on honey bee researchat MSU, honey bee pathogens, honey bee pathogen detection (YouTube) * Timestamps by Jolene. Thanks!
Weekly Science Picks Michelle - First 21 days of a bee's life; NPR's Hidden Brain; Varroa destructor triggers deformed wing virus in bees Brianne - Flu Near You Alan - Skype a Scientist program
Rich- NASA's Voyager 2 Probe Enters Interstellar Space
Kathy- Which ones are bees? And What it feels like to be a bee
Vincent - Fecal sequencing and Vaccines did not cause Rachel's autism by Peter Hotez
Intro music is by Ronald Jenkees.
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Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein.
Hosts: Vincent Racaniello and Amy Rosenfeld
Guest: Raul Andino
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Links for this episode * TWiV 138: RISCy business with Raul Andino * TWiV 33: Live in Philly * Viral protein restricts insect immunity (Cell Host Micr) * Timestamps by Jolene. Thanks!
Weekly Science Picks Amy - Insectropolis
Vincent- Genome-edited baby
Intro music is by Ronald Jenkees.
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At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus.
Hosts: Vincent Racaniello
Guests: Cornel Fraefel, Urs Greber, and Silke Stertz
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Links for this episode * AAV2 and HSV1 co-infections (J Virol) * Movies of HeLa Fucci cells (J Virol) * Cathepsin W and influenza virus entry (mBio) * Plaque 2.0 (PLoS One) * Video of this episode (YouTube) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episode * Genome-edited babies (Nature) * Second CRISPR pregnancy? (MIT Tech Rev) * Naturally occurring DNA virus of Drosophila (PLoS Path) * Upstream protein coding region in enterovirus genome * We missed it in 1988! (J Virol) * Letters read on TWiV 522 * Timestamps by Jolene. Thanks!
Weekly Science Picks Alan - $40 internationally standard cup of tea
Rich- Mars InSight Mission
Dickson- New York Botanical Garden Train Show
Kathy- Comedy wildlife photo awards finalists
Vincent - Senator Gillibrand calls for funding AFM research and our Crowdsourcing of EV-D68 research
Listener Pick Fernando - Pathfinders by Felipe Fernández-Armesto; Erebus by Michael Palin
Intro music is by Ronald Jenkees.
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Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai * 30,000 year old Mollivirus sibericum (PNAS) * Aggregating viruses promotes early replication (Curr Biol) * Letters read on TWiV 521 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Why don't we have vaccines against everything?
Rich- Golden Globe Race
Dickson- The Anatomy of Figure Drawingby Robert Demarest and Warder Clyde Allee
Kathy- Orientation of the moon’s appearance, Southern Hemisphere
Vincent - Paul has Measles in English and Spanish
Intro music is by Ronald Jenkees.
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The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine at Mount Sinai * MSc program Molecular Biology and Pathology of Viruses, Univ College London * Virology Comics on sale (Amazon) * Outbreak at the Smithsonian * NIAID strategic plan for universal influenza vaccine * Fauci article on universal influenza vaccine (J Inf Dis) * Severe 2017-18 flu season (CDC) * Progress on universal influenza vaccine (The Scientist) * Influenza vaccine is safe for those with egg allergies * Atypical parvovirusdrives mouse kidney disease (Cell) * Contagious Thinking: Visible Viruses AR app * Letters read on TWiV 520 * Timestamps by Jolene. Thanks!
Weekly Science Picks 1:17:24 Brianne - Nebula Genomics: a new start-up offering free genome sequencing (with a catch)
Alan- GRE scores are poor predictorof degree completion
Rich- The Science Mill(video)
Dickson- The 12 cranial nerves (mnemonic)
Kathy- NAS report on Sexual Harassment of Women (free pdf) Iceberg figure
Vincent - The Tangled Tree by David Quammen and TWiEVO #37
Listener Pick Mark- Weekly US Map: Influenza Summary
Intro music is by Ronald Jenkees.
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The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Virology Comics on sale (Amazon) * Clinical Trial: antiviral for AD * HHV6 and HHV7 transcripts in AD brain (TWiV 505) * HSV1 in AD (Front Ag Neuro) * Taiwan cohort study on antivirals and AD (Neurother) * HSV1 antibodies in CSF (J Med Virol) * HSV1 induces amyloid-beta fibrillization (Neuron) * Image credit * Letters read on TWiV 519 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Pandemic (board game)
Alan- The Shortwave Radio Audio Archive (siteand blog)
Rich- James Cook's First Pacific Voyage, 1768-1771 (interactive map)
Dickson- The Scientist on Instagram
Vincent - State of the World’s Fungi
Listener Pick David- Bruno LaTour
Intro music is by Ronald Jenkees.
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Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses.
Host: Vincent Racaniello
Guests: Nicholas Buchkovich and Leslie Parent
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Links for this episode * HIV-1 gag membrane binding domain (J Virol) * Nuclear experience for gag (PNAS) * Gag in nucleolus (J Virol) * YB-1 for retrovirus assembly (J Virol) * HCMV controls BiP levels (J Virol) * HCMV regulates La (J Virol) * Inhibition of HCMV by modulating syntaxin 5 (J Virol) * Non-envelopment role for ESCRT-III during HCMV infection (J Virol) * Late retroviral budding function (J Virol) * Grit by Angela Duckworth * The Scientists by John Gribbin * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.
Hosts: Vincent Racaniello and Brianne Barker
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Links for this episode * Pan American Society for Clinical Virology San Diego and Houston Regional Meetings * It's not SARS 2.0 (TWiV 364) * Bats out of hell (TWiV 183) * Bombali virus, a new Ebolavirus (Nat Micro) * Asymptomatic Ebolavirus infections (virology blog) * Bat-borne mumps virus (Cell Rep) * Image credit * Letters read on TWiV 517 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Ed Yong on AFM
Vincent - Goggles Optional podcast (especially #243)
Intro music is by Ronald Jenkees.
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Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker
Guests: Leonid Yorkovetskiy and Jeremy Luban
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Links for this episode * Pan American Society for Clinical Virology San Diego and Houston Regional Meetings * Vpr and Vpx counter HUSH (Nat Micro) * Vpr and Vpx counter HUSH (bioRxiv version) * Schematic of HUSH complex (Lehner lab) * Olive colobus monkey sound credit * Image credit: William (Ted) Diehl * Letters read on TWiV 516 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - The Chimp and the River by David Quammen
Rich- James Cook’s First Voyage Journal (20 sec Google Earth summary)
Kathy- High resolution Antarctica map NYTimes 46MB Maps (more info and 43 tb maps)
Dickson- Jellyfish
Jeremy - Pictorial Guide to Living Primates; All The World's PrimatesLonya- Chougui et al. HIV-2/SIV Vpx counters HUSH
Vincent - Research!America
Intro music is by Ronald Jenkees.
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The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * Sea Phages program and application materials * Tom Steitz, 78 (NY Times) * AFM outbreak, US (CIDRAP) * AFM surveillance (CDC) * Acute Flaccid Paralysis and Enteroviral Infections (Curr Inf Dis Rep) * EV-D68 neurotropism (bioRxiv) * Ebola virus outbreakcontinues in DRC (CIDRAP) * Vaccinia virus respiratory infection (Int J Inf Dis) * HPV L2 penetrates endosome, brings virus retro (Cell) * Letters read on TWiV 515 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Germ City-Microbes and the Metropolis Museum Exhibition Alan- Nikon 2018 Small World in Motion competition
Kathy- Ion Torrent Sequencing (video)
Dickson- 2018 Nobel Prizes Economics
Kathy- Ocean-centric map
Vincent - Intelligence Matters Podcast: Anthony Fauci on threats from epidemics
Listener Picks Gonsalo - Cells at Work (Manga, Anime)
Intro music is by Ronald Jenkees.
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The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episode * Sea Phages program and application materials * Plant biologists penalized by CNRS (The Scientist) * 2018 Nobel Prize in Medicine (pdf) * 2018 Nobel Prize in Chemistry (pdf) * 2018 Nobel Prize in Physics (pdf) * 2018 Nobel Peace Prize (Nobel) * Mitochondrial dsRNA triggers IFN (Nature) * Letters read on TWiV 514 * Timestamps by Jolene. Thanks!
Weekly Science Picks 1:28:33 Alan- Compound Interest chemistry graphics
Kathy- Writing letters of recommendation Guidelines Trix & Psenka Schmader et al. Madera et al.
Dickson- Japan Fireworks
Vincent - The Game of T-Cells and Apple Park Lego
Listener Picks Steve - Shomu's Biology
Intro music is by Ronald Jenkees.
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From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus.
Host: Vincent Racaniello
Guest: Harry Greenberg
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Links for this episode * 13th dsRNA Virus Symposium * Hepatitisin blood donors (Lancet) * Interferon treatmentof hepatitis B (NEJM) * Mycoplasmamutantsin volunteers (PNAS) * Norwalk virus infectionof chimpanzees (J Med Virol) * Rotavirus rescueby reassortment (PNAS) * Cold-adaptedinfluenza vaccine (Virol) * Rotavirus correlates of protection(Curr Opin Virol) * Rotavirus vaccine and intussusception(NEJM) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Brianne Barker, and Anne Simon
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Download TWiV 512 (62 MB .mp3, 103 min)
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Links for this episode * Support Viruses Gordon Conference3:38 * Potyvirus (ViralZone) * Plum pox (Wikipedia) * History, biology, management of plum pox (Mich St Ext) * Papaya ring spot virus (Bus Man) * Geminivirus (ViralZone) * Geminivirus rep impairs PCNA SUMOylation (J Virol) * Image credit * Letters read on TWiV 512 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne - Why are so many genes unstudied? (Zimmerand Yong)
Alan - Unveiling the RNA World
Rich - Spaghetti mystery solved (PNAS paper)
Dickson - Science Fair
Vincent - A PhD Lab Coat Ceremony
Listener Picks Stephen - Flu vaccine myth rant by Crislip
Jolene - Research Matters in PLoS Path and PLoS Biology
Nicholas - Charity Matters app
Intro music is by Ronald Jenkees.
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Ned Landau joins the TWiV team to discuss restriction of HIV replication by SAMHD1, and a viral antagonist that can be used to produce a dendritic cell vaccine.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
Guest: Ned Landau
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Links for this episode * Support Viruses Gordon Conference * TWiV #124 September 2008 * SAMHD1 restricts HIV-1 replication (Nature) * SAMHD1 restricts diverse retroviruses (Retrovirology) * Vpx degradation of SAMHD1 independent of uncoating (J Virol) * Transduction of myeloid cells with Vpx vector (Gene Ther) * Letters read on TWiV 511 * Timestamps by Jolene. Thanks!
Weekly Science Picks Brianne- Online Immunology Course
Alan- Bacteria Builder
Rich- 2018 Ig Nobel Prizes
Dickson- Between Fear and Hope
Ned - HUSH silencing of transposons
Vincent - Paywall publishing ban (Schlitz statement); Curry on DORA
Listener Pick Steve- Paywall: Business of Scholarship and Biohazard
Islam- Peer review Twitter post
Intro music is by Ronald Jenkees.
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Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1.
Hosts: Vincent Racaniello and Dickson Despommier
Guests: John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata
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Links for this episode * Cold Spring Harbor Retrovirus Meeting 2018 * Retroviruses and cranberries (TWiV 320) * Identical proviruses in HIV-1 reservoir (PLoS Path) * Measuring HIV-1 latency (PNAS) * CG dinucleotide suppression is host defense (Nature) * Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
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The TWiV team considers whether those who can do, can't teach, and newly discovered viruses of planarians and Aplysia with the largest RNA genomes.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler and Brianne Barker
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Links for this episode * Support Viruses Gordon Conference * KNAW Beijerinck Prize * Bioterrorism and Biocrimes by Seth Carus (free pdf) * History of Biological Warfare by Seth Carus (free) * Those Who Can Do, Can't Teach (NYTimes) * Planarian nidovirus (bioRxiv) * Aplysia nidovirus (bioRxiv) * Image credit * Letters readon TWiV 509
Weekly Science Picks Brianne- Climate change visualization
Alan- Anova sous vide cooker
Dickson- Fire season in western US
Kathy- Sunscreen in UV and The Projector Illusion
Vincent - The Usefulness of Useless Knowledge
Listener Pick River- The Conscience of the Present
Intro music is by Ronald Jenkees.
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Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Jens Kuhn
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Links for this episode * Russia's Bioweapons Labs (Nature) * Medical Aspects of Biological Warfare * The Soviet Biological Weapons Program by Leitenberg, Zilinskas, Kuhn * Biological Threats in the 21st Century by Lentzos * Bioterrorism and Biocrimes by W. Seth Carus * Russia's Secret Weapons (Nature) * Image credit
Weekly Science Picks Jens - Nudibranchs, Beastly Garden, large nidovirus (one, two) Rich - Living inside a canister Dickson - Global rivers and streamsKathy - TWiM 181 Dr. Warhol’s Periodic Table of Microbes
Vincent - Twitter Bots and Russian Trolls Amplify Vaccine Debate
Intro music is by Ronald Jenkees.
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The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker
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Links for this episode * Support Viruses & Cells Gordon Conference * Outbreak at the Smithsonian * Outbreak (TWiV 501) * Latest Ebola virus outbreak, DRC (WHO) * Summary of Ebola virus outbreaks (CDC) * Ebola virus nomenclature (ICTV) * Ebola virus distribution map (CDC) * Polarization of vaccinia virus membrane proteins (bioRxiv) * Image credit * Letters read on TWiV 507
Weekly Science Picks Alan - Puzzled Escape Games Rich - An Extremely Detailed Map of the 2016 Election Dickson - Parker Solar ProbeKathy - Ancient earth globe and connected Dinosaur database Brianne - STEMM education should get HACD
Vincent - Free tuition for all NYU medical students
Listener Pick Heather- GoFarm blog
Intro music is by Ronald Jenkees.
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David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episode * Articleby Lubet and Tuller (STAT) * David's Australian trip (virology blog) * Sir Simon scores own goal (virology blog) * Lightning process (virology blog) * Letter to Parliament (virology blog) * Crowdfunding is not conflict of interest (virology blog) * Open letter to Lancet 3.0 (virology blog) * Mayo still champions GET (virology blog) * Image Credit
Intro music is by Ronald Jenkees.
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The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker
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Links for this episode * Support Viruses & Cells Gordon Conference * New DRC Ebola strains distinct (Outbreak News) * Immunizations for new DRC Ebola outbreak (The Scientist) * Structure of Cafeteria roenbergensis virus (Sci Rep) * Chuan (River) Xiao laboratory * CroV movies * Scaled deployment of Wolbachia(Gates Open Res) * In the wake of Wakefield (BBC) * Letters read on TWiV 506
Weekly Science Picks Alan - Ebola research begins at the NEIDL Dickson - Science Photo Library Brianne - First liquid water (underground lake) found on Mars
Vincent - Thirty years ago, we could have saved the planet
Listener Pick Edmund- STEM talk
Intro music is by Ronald Jenkees.
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The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker
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Links for this episode * Support Viruses & Cells Gordon Conference * Trump picks science advisor (Scientist) * Hendra vaccine: no effect on horses racing (Aust Vet J) * Persistence of Ebola virus (Lancet Inf Dis) * New Ebolavirus outbreak (Telegraph) * Alzheimer's disease and herpesviruses (Neuron) * Herpesviruses, beta-amyloid and Alzheimer's disease (Neuron) * Letters read on TWiV 505
Weekly Science Picks Alan - Impossible Burger Rich - SpaceX Just Sent Algae to the ISS, Here's How It'll Power Deep Space Missions Dickson - Art and Science Intersection (Art Science Museum) Brianne - Why it is not a 'failure' to leave academia
Kathy- 2003 video history of nuclear explosions 1945 - 1998
Vincent - Revisionist History Episode 8 and Episode 9
Listener Pick Mark- TWIV bingo (png)
Intro music is by Ronald Jenkees.
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The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Links for this episode * Support Viruses & Cells Gordon Conference * TWiV 501: Outbreak * Nipah virus infection (JCM) * Anatomy of an outbreak (The Hindu) * Do we need to worry about Nipah virus? (Tufts Now) * Nipah virus infection of bats (EID) * Papua New Guinea no longer polio-free (virology blog) * WHO polio endgame (polioeradication) * Letters read on TWiV 504
Weekly Science Picks Alan - Glaciers of the Rockies aerial photos Rich - SpaceX CRS-15 mission to the space station(wiki) Dickson - Test of Einstein's theory of relativity Brianne - biorender
Vincent - True or False? with Michael Schmidt
Listener Pick Jolene- Dogs cannot get autism
Intro music is by Ronald Jenkees.
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Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Svetlana Folimonova and Anne Simon
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Links for this episode * Simon laboratory * Folimonova laboratory * CTV superinfection exclusion (Virol) * 3'-CITEs in viral genome (J Virol) * Video of this episode (YouTube)
Intro music is by Ronald Jenkees.
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The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Jason Gill and Ry Young
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Links for this episode * Center for Phage Technology at TAMU * Personalized phage therapy (PNAS) * Phage for biolipid extraction (Sci Rep) * Viral protein antibiotic (Nat Micro) * Acinetobacter phage depolymerase (J Virol) * Structure of phage Qβ (PNAS) * Video of this episode (YouTube)
Intro music is by Ronald Jenkees.
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Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World.
Host: Vincent Racaniello
Guests: Sabrina Sholts, Jon Epstein, and Ed Niles
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Links for this episode * Sabrina Sholts * Jonathan Epstein * EcoHealth Alliance * Outbreak at the Smithsonian * ASM partners with Smithsonian (bLog Phase) * Vincent as museum object (AMNH) * Video of this episode (YouTube)
Intro music is by Ronald Jenkees.
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The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Jinny Suh, Jason McClellan, and Jon Huibregtse
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Links for this episode * A big list of science podcasts * Immunize Texas * McClellan Lab * Huibregtse Lab * John Ring LaMontagne Center for Infectious Disease * Video of this episode (YouTube)
Weekly Science Picks Alan - The Airplane Cabin Microbiome Rich - Coalition for Epidemic Preparedness Innovations (CEPI)(wiki) Dickson - The Big Five Mass Extinctions Kathy - Virus scarves at Red Bubble phage-specific variety
Vincent - Science podcasts
Listener Pick Maureen- 12 year old takes on Flint's Water Crisis
Intro music is by Ronald Jenkees.
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Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research.
Hosts: Vincent Racanielloand Alan Dove
Guests: Nathalie Grandvaux, Craig McCormick, Kate O'Brien, and Ryan Noyce
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Links for this episode * TWiV 2018 World Tour * CSV 2018 * To wheeze or not to wheeze (Lancet Respir Med) * Synthetic infectious horsepox (PLoS One)
Intro music is by Ronald Jenkees.
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Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Stacy Hornerand Ken Stapleford
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Links for this episode * TWiV 2018 World Tour * RNA modifications go viral(Plos Path) * N6-methyladenosinein flavivirus genomes (Cell Host Micr) * Chikungunya virus evolution(Cell Host Micr)
Intro music is by Ronald Jenkees.
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At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research.
Hosts: Vincent Racanielloand Rich Condit
Guests: Sasha Gorbalenya, Jim Hogle, Ann Palmenberg, and Frank van Kuppeveld
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Intro music is by Ronald Jenkees.
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Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction.
Hosts: Vincent Racanielloand Rich Condit
Guests: Stacey Schultz-Cherry, Douglas Diekema, and Andrew Noymer
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Links for this episode * ASM Microbe 2018 * Support Viruses & Cells Gordon Conference * Faculty positions at Icahn School of Medicine * International dsRNA Virus Symposium * Dummheit (Healthc Policy) * Universal influenza vaccine (mBio) * Vaccine personal belief exemptions (Ann Rev Pub Health)
Intro music is by Ronald Jenkees.
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The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episode * ASM Microbe 2018 * Support Viruses & Cells Gordon Conference * Faculty positions at Icahn School of Medicine * International dsRNA Virus Symposium * Tracing Ebola virus contacts(CIDRAP) * WHO FAQ Ebola virus vaccine(WHO) * Nipah virusoutbreak (CIDRAP) * Revealingparasitoid to hyperparasitoid (PNAS) * Hyperparasitoidvideo (YouTube) * Calcium channeland influenza virus entry (Cell Host Microbe) * Letters readon TWiV 495
Weekly Science Picks Alan - National Cryptologic Museum Rich - Science is mostly about staring Dickson - New Zealand gloworms Kathy - Openingof Smithsonian Outbreak; conference advice General ASV
Vincent - ICTV online
Intro music is by Ronald Jenkees.
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Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episode * ASM Microbe 2018 * Support Viruses & Cells Gordon Conference * Faculty positions at Icahn School of Medicine * International dsRNA Virus Symposium * New Ebola virus outbreakin DRC (WHO) * Ebola virus case in urban area of DRC(WHO) * Ebola virus outbreak not PHEIC(WHO) * Ebola virus vaccinearrives in DRC (CIDRAP) * Recent Ebola-Makona mutationsdo not alter pathogenesis (Cell Rep) * Letters readon TWiV 494
Weekly Science Picks Alan - Happy 35th birthday, PCR Kathy- Everything can be a speaker
Vincent - Ocean rise due to rocks(debunked); Gates advises Trump on viruses
Listener Pick Noah- David Baltimore on iBiology
Intro music is by Ronald Jenkees.
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The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASM Microbe 2018 * Support Viruses & Cells Gordon Conference * Faculty positions at Icahn School of Medicine * FDA meeting materials for tecovirimat(FDA) * SIGA Briefing Information (pdf) * Errata to the SIGA Briefing Information (pdf) * Gut immune cells major targets of norovirus infection(Nat Micro) * RNAscope(J Mol Diag) * Image credit * Letters readon TWiV 493
Weekly Science Picks Alan - Personal Finance for PhDsby Emily Roberts
Kathy- Optical illusions fool artificial intelligence
Rich- 2017-2018 snowfall graphic
Dickson- Dust from the Sahara
Vincent - The Last Days of Smallpoxby Mark Pallen
Listener Pick Intro music is by Ronald Jenkees.
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The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASM Microbe 2018 * Support Viruses & Cells Gordon Conference * Faculty positions at Icahn School of Medicine * Norovirus outbreaks from nori(Emerging Inf Dis) * SHERLOCK(Science) * HUDSON(Science) * DETECTR(Science) * Letters readon TWiV 492
Weekly Science Picks Alan - Decline of local newspapers leaves epidemiologists blind
Kathy- Journal oversight, mental health research
Rich- The Big Sort: An Insider's Tour of a Recycling Plant
Dickson- When Science Meets Art
Vincent - A Crack in Creationby Doudna and Sternberg
Listener Pick Tom- Trillions Upon Trillions of Viruses Fall From the Sky Each Day
Intro music is by Ronald Jenkees.
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The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASM Microbe 2018 * Support Viruses & Cells Gordon Conference * Faculty positions at Icahn School of Medicine * Evolutionary historyof RNA viruses (Nature) * The amphioxus song * Norovirus tropism for tuft cells(Science) * Letters readon TWiV 491
Weekly Science Picks Alan - Oligodendroglioma in song Kathy- Everything-repellent coating to grime proof phone screens & more
Rich- Gaia star map
Dickson- Clouds are complicated
Vincent - Eradicating polio with a vaccine we must stop using
Listener Pick Stephen- Forget the Avengers, it took real heroes to make India polio-free
Intro music is by Ronald Jenkees.
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From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episode * ASM Microbe 2018 * ASV Job Site revamped * Support Viruses & Cells Gordon Conference * Faculty positions at Icahn School of Medicine * Dick Courtney obit * Human cowpox infection(NEJM) * Mimivirus encodes fermentation genes(Virology) * Letters readon TWiV 490
Weekly Science Picks Kathy- Landscapes that look like another world (but they are from Spain)
Rich - Brighton Collaboration; Viral Vector Vaccines Safety Working Group (V3SWG)(Chen & DeStefano: Vaccine adverse events: causal or coincidental?) Dickson- Clouds of Jupiter and EBNA2 and autoimmunity
Vincent - More than one-third of graduate students report being depressed (original article)
Intro music is by Ronald Jenkees.
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Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'.
Host: Vincent Racaniello
Guest: Sandra Urdaneta-Hartmann
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Links for this episode * CD4 Hunter iOSAndroid * Sandra on Twitter * Carla Brown on Twitter * Inactivation of HIV in breast milk(Retrovirology) * Nipple shieldto inactivate HIV (Int J Pharm)
Intro music is by Ronald Jenkees.
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The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episode * ASM Microbe 2018 * ASV 2018 * Microbiology Student Symposium at UC Berkeley * Support Viruses & Cells Gordon Conference * Waning mumps vaccinein US (Sci Trans Med) * siRNA controlof West Nile virus brain infection (Cell Host Microbe) * Image credit * Letters readon TWiV 488
Weekly Science Picks Kathy- Peak bloom and photographing cherry blossoms
Dickson- Origins of vertebrate RNA viruses
Alan- Rare footage of anglerfishin the deep ocean
Vincent - NIH must reduce disparities in funding
Listener Picks Mariann - Eden Project and Bellyvision Apparatus and the Like
Amir- Winners of ICR Science Photography and Photography Contest
Intro music is by Ronald Jenkees.
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At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers.
Host: Vincent Racaniello
Guests: Dominique Carter, Sid Grossberg, John Kirby, Scott Terhune, and Vera Terakanova
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Intro music by Ronald Jenkees
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Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more.
Host: Vincent Racaniello
Guest: Sean Whelan
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Links for this episode * Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 (Nature) * Lassa virus entry requires a trigger-induced receptor switch (Science) * Infectious Entry Pathway Mediated by the Human ERV K Envelope Protein (J Virol) * Novel Broad-Spectrum Virus Entry Inhibitor (J Virol) * Mechanism of membrane fusion induced by VSV G protein (PNAS) * NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry (Cell Host Micr) * Image credit
Intro music by Ronald Jenkees
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The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * ASM Microbe 2018 * Insulin-like peptides in Iridovirus genomes (PNAS) * Dicer-2 dependent generation of cvDNA from defective genomes (Cell Host Micr) * Carla Saleh on insect antiviral immunity (TWiV 301) * RNAseIII ancient antiviral RNA platform (TWiV 450) * cvDNA precursor to EVEs (TWiV 482) * Image credit: Paul Young * Letters read on TWiV 485
Weekly Science Picks Kathy - Vegas casinos lost money on physicists
Brianne - Astronaut twin's DNA is not 7% different!
Dickson - Parasitic Diseases lecture videos
Alan - In Season blog by Donna Long
Vincent - Buckyball viruses
Listener Picks Paul - Wine labels (front, back)
Intro music is by Ronald Jenkees.
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The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * ASM Microbe 2018 * Tailed giant Tupanvirus (Nat Commun) * Soda Lakes (Wikipedia) * Dampened STING in bats (Cell Host Microbe) * Image credit * Letters read on TWiV 484
Weekly Science Picks **Kathy** - How to read a phylogenetic tree
Brianne - No immune overload for vaccines
Dickson - Flowchart of viral families
Alan - Letters to a Pre-Scientist
Vincent - True believers, entrepreneurs, and scammers in alternative medicine and Simply Put: Vaccines Save Lives
Listener Picks Vinayaka - Code of Ethics for Young Scientists
Matt - TWiV 443
Intro music is by Ronald Jenkees.
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Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
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Links for this episode * USA Science and Engineering Festival * Genital inflammation and antiviral effectiveness (Nat Med) * Single cell infection heterogeneity (eLife) * Single-cell poliovirus infection (Virology) * Image credit * Letters read on TWiV 483
Weekly Science Picks **Kathy** - Dance Dance
Rich - Snopes
Alan - Next Generation Science Standards
Vincent - TWiEVO 28: Genetics of skin pigmentation in Africa
Intro music is by Ronald Jenkees.
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The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker
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Links for this episode * USA Science and Engineering Festival * Ebolavirus infection without an outbreak (J Inf Dis) * A. aegypti EVEome (Curr Biol) * One Loop to Rule Them All (Trends Biochem Sci) * Image credit * Letters read on TWiV 482
Weekly Science Picks **Kathy** - Origami sound barrier
Brianne - iBiology
Dickson - Switched-on bats
Alan - Hawaii’s communication breakdown
Vincent - Inside the Federal Bureau of way too many guns and What I Saw Treating Parkland Victims
Listener Pick Johnye - Debunking Anti-Vaxxers
Intro music is by Ronald Jenkees.
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The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * HaHa influenza virus (mBio) * MERS coronavirus intestinal transmission (Sci Adv) * Simulated gastric and intestinal fluids * Stomacher * Defective genomes and severe influenza (PLoS Path) * Image credit * Letters read on TWiV 481
Weekly Science Picks **Kathy** - CD45.1 and CD45.2 mice may not be functionally equivalent
Rich - Relative humidity versus dewpoint (video)
Dickson - Underwater photography winners
Alan - Photo of a single atom
Vincent - Proposed Federal science budget cuts and The Blog is Dead
Listener Pick Jess - Louis Tompkins Wright
Intro music is by Ronald Jenkees.
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Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Scott Hensley
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Links for this episode * Weekly influenza surveillance (CDC) * Influenza vaccination status (CDC) * H3N2 glycosylation site and eggs (PNAS) * Influenza virus in exhaled breath (PNAS) * Geometric Defects and Icosahedral Viruses (Viruses) * Image credit * Letters read on TWiV 480
Weekly Science Picks **Kathy** - Flow Virometry
Rich - Falcon Heavy Launch links: Flight diagram; Launch including booster landing; Tesla in space; Tesla orbit; Reusable booster failures; Booster size
Dickson - Next generation of weapons
Alan - Ed Yong’s story on fixing gender imbalance in science reporting
Vincent - CD4 Hunter iOS Android
Intro music is by Ronald Jenkees.
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The TWiVome explores induction of antiviral responses by repeating patterns of capsids, and a fungus in the mosquito gut that aids dengue virus replication.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Innate immune detection of capsid patterns (mBio) * Mosquito gut fungus aids dengue virus replication (eLife) * Nominate MicrobeTV for a Keck award * Image credit * Letters read on TWiV 479
Weekly Science Picks **Kathy** - Great Lakes, false color
Rich - Times 360 Lego factory tour
Dickson - 3D printed houses
Alan - The new terms for trust in journalism
Vincent - A Tale of Two Cultures and Why Science Blogging Still Matters
Listener Picks Jolene - Immune Quest
Intro music is by Ronald Jenkees.
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The TWiV team explains how infectious horsepox virus - likely the ancestor of smallpox vaccines - was recovered from chemically synthesized DNA fragments.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * Potential Zika virus related birth defects, USA (MMWR) * Bordering on an outbreak (Tex Obs) * Horsepox virus from synthesized DNA (PLoS One) * Horsepox based smallpox vaccine (NEJM) * Has horsepox become extinct? (Vet Rec) * Evolutionary path of smallpox vaccines (Lancet Inf Dis) * Equination (Vaccine) * Image credit * Letters read on TWiV 478
Weekly Science Picks **Kathy** - UM EEB photo contest
Rich - Dino-Lite digital microscope and digital microscope camera
Dickson - Sandford Photography
Alan - A list of female virologists
Vincent - Virology Lectures 2018
Listener Picks Andrew - Interferome
Neva - The Untreatable by Gavin Francis
Intro music is by Ronald Jenkees.
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The TWiVodrome explains how a gag-like protein from a retrotransposon forms virus-like particles that carry mRNA within vesicles across the synapse.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * Arc virus-like particles transport RNA across the synapse (mammalian, Drosophila) * Chemical synapse (Wikipedia) * 2 minute video on the neuron * Image credit * Letters read on TWiV 477
Weekly Science Picks **Kathy** - Ice cliffs form over the weekend
Rich - The Courage To Invent: A NASA Roboticist Tells Her Story (Ayanna Howard)
Dickson - 2017 Was One of the Hottest Years on Record
Alan - Experimenter gender and replicability
Vincent - Set Your Autocorrect to Change 'Guys' to 'Folks'
Listener Picks Asal - 100 million chickens with avian flu
Mark - Dr. Tatiana's Sex Advice to All Creation
Intro music is by Ronald Jenkees.
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Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Nels Elde
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Download TWiV 476 (63 MB .mp3, 105 min)
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * TWiV is a must-listen (WaPo) * More on poxvirus accordions (bioRxiv) * HBV from a 439 year old mummy (PLoS Path) * lncRNA promotes viral replication by inducing metabolism (Science) * Making Data Visual * Letters read on TWiV 476
Weekly Science Picks **Nels -** Everyday Evolution **Kathy** - Paper-fold an ellipse
Rich - Oxford Nanopore Technologies: YouTube channel; General technology; DNA sequencing; Sequencing singularity
Dickson - Spiders that look like pelicans
Alan - Guessing pool for China Spacelab reentry
Vincent - How to take a picture of the stealth bomber over the rose bowl
Listener Picks Gretchen - The Bearded Lady Project
Intro music is by Ronald Jenkees.
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In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * Virology stories of 2017 - in no particular order 1. A virologist in space - TWiV 444 2. Cool things viruses do: Astrovirus capsids are enterotoxins TWiV 423; giant Klosneuviruses encode lots of stuff for translation TWiV 437; Giant Noumeaviruses quickly make the nucleus temporarily leaky TWiV 440 3. TWiV 438 Drs. TWiV go to Washington and the March for Science 4. Unexpected stuff: TWiV 451 Expectorate the unexpected; TWiV 470 Just a passing phage; TWiV 456 Be careful of canons; TWiV 455 Pork and genes; TWiV 432 gamete fusion protein from viruses 5. TWiV 443 On a leaf no one can hear you scream. The puppet master. 6. TWiV 448 Mavis the structure maven 7. Viruses are us: TWiV 472 Riddle of the skinks; TWiV 439 The purloined envelope; TWiV 434 Live long and pupate 8. Antiviral RNA: TWiV 433 Poops viruses and worms; TWiV 449 The sound of non-silencing; TWiV 450 Ben tenOever and RNA out 9. Viruses as tools: TWiV 461 Gotta trace them all 10. Flaviviruses: TWiV 473, 471, 468; 458; 454; 451; 432; 430; 429; 426 * NSF survey of earned doctorates * Letters read on TWiV 475
Weekly Science Picks **Kathy** - Voyager recording and book
Rich - David Sheldrick Wildlife Trust (Maktao)
Dickson - Global Croplands Map
Alan - The Great Influenza one day at a time
Vincent - The Doomsday Machine by Daniel Ellsberg
Listener Picks Mark - Science Moms and Science of HIV
Andy - Ask Me Anything
Steve - Critical Attitude in Medicine
Intro music is by Ronald Jenkees.
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The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth's waters.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * Support Microbe.tv * Anti-dengue antibody and disease (J Inf Dis) * Bodo saltans virus (biorXiv) * Kinetoplast DNA (Euk Cell) * Crossword puzzle for book contest (pdf) * Letters read on TWiV 474
Weekly Science Picks **Kathy** - Every second
Dickson - Top 10 Science Images 2017
Alan - Shortwave Radiogram
Vincent - Science March on Instagram
Listener Picks Islam - Class Crossword (Armored Penguin)
Peter - The Last of the Iron Lungs
Intro music is by Ronald Jenkees.
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The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * Support Microbe.tv * NEIDL is approved * NIH lifts GOF moratorium (Science) * Blackburn steps down as head of Salk Institute (SD Union Trib) * ADE of dengue disease in humans (Science) * Commentary on ADE of dengue disease (Science) * ADE of dengue disease and antibody binding to Fc (Science) * Letters read on TWiV 473
Weekly Science Picks **Kathy** - Today in Science History
Dickson - 10 Breakthrough Technologies 2017
Rich - SpaceX to orbit a Tesla
Alan - Debt in America
Vincent - The Death of Expertise by Tom Nichols (NYTimes review)
Listener Picks Stephen - A Concise Paper
Johnye - Holiday song parodies (one, two, three)
Tom - SMBC: Are viruses alive?
Intro music is by Ronald Jenkees.
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Vincent speaks with professional podcast producer Ray Ortega about his career and the power of the podcast.
Host: Vincent Racaniello
Guest: Ray Ortega
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Links for this episode * Ray on Twitter * The Podcasters' Studio * Produce Picker Podcast * Ray's YouTube channel
Intro music is by Ronald Jenkees.
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The TWiV team reveal the origin of the poxvirus membrane, and how a retrovirus drove the development of the placenta of a lizard.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * Support Microbe.tv * Origin of poxvirus membrane (PNAS) * Poxvirus movies: Movie S1, Movie S2, Movie S3, Movie S4, Movie S5 * Lizard placenta from a retrovirus (PNAS) * Letters read on TWiV 472
Weekly Science Picks **Kathy** - Google doodles Discoverer of photosynthesis Robert Koch
Dickson - Nature Photography Winners
Rich - The Raging Idiots Planet Song
Alan - Zooborns
Vincent - Glass Insects and Plants by Yuki Tsunoda
Listener Picks Scott - Sagan Series
Paul - SMBC Comics
Trudy - If Scientists Wrote Christmas Songs
Intro music is by Ronald Jenkees.
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The TWiVerinos discuss restriction of dengue virus vaccine by Sanofi, and data which suggest that Dengvaxia causes enhanced disease in previously uninfected recipients.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASV 2018: asv.org, asv2018.umd.edu * Sanofi update on Dengvaxia * Trouble for dengue vaccine (Reuters) * Sanofi restricts dengue vaccine (CIDRAP) * Dengvaxia enhances disease (Vaccine) * Interview with Jeff Almond * Dengue vaccine on TWiV 319, TWiV 370, TWIV 384 * Image credit * Letters read on TWiV 471
Weekly Science Picks **Kathy** - NASA is reinventing the wheel
Dickson - Stunning neuroscience images
Rich - Moneyball by Michael Lewis (film)
Alan - Diverse Sources
Vincent - Zombie gene protects elephants from cancer (Quanta, TWiEVO)
Listener Picks Scott - Why Vaccines Matter by Cynthia Gorney and The Song of the Dodo by David Quammen.
Intro music is by Ronald Jenkees.
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The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Transcytosis of bacteriophage across cell layers (mBio) * Image credit * Letters read on TWiV 470
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.
Weekly Science Picks Kathy - Photo of 3200 year-old tree in one image
Dickson - Microsculpture
Rich - A Short History Of Humans And Germs
Alan - Planets app
Vincent - Laptops Are Great. But Not During a Lecture or a Meeting
Listener Picks Basel - Joint Pathology Center
John - OpenStax
Intro music is by Ronald Jenkees.
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The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Phytopathogenic fungus hosts a plant virus (PNAS) * Franklin column (PNAS) * Potato famine mystery solved (History) * Protein Data Bank * You do not need to work 80 hours per week (THE) * How I Learned To Stop Worrying (Sci Am) * Image credit: Truth Wins by Jon Yewdell * Letters read on TWiV 469
This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm
This episode is brought to you by the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.
Weekly Science Picks Kathy - Patterns Video (WonderLab)
Dickson - Nikon 2017 Photomicrography Contest
Rich - Leonardo Da Vinci by Walter Isaacson
Alan - Sail Magazine Best Boats 2018
Vincent - Science Is Dry, Obscure, Complex?
Listener Picks Ben - Is the staggeringly profitable business of scientific publishing bad for science?
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Amy Rosenfeld
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Links for this episode * Grad students face tax hike (Nature) * House voted to bankrupt grad students (NYTimes) * Neurotropism of early and late Zika virus isolates (PNAS) * Zika virus blocks the neuron road (virology blog) * Letters read on TWiV 468
This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm
This episode is brought to you by the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research.
Hosts: Vincent Racaniello, Alan Dove,and Rich Condit
Guest: Jon Yewdell and Teddy Yewdell
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Links for this episode * Jon Yewdell laboratory * Chaudhuri laboratory * Truth Wins by Jon Yewdell (epub or mobi download) * Noncoding RNAs and class switch recombination (Int Imm) * Translating DRiPs (J Leuk Biol) * Lamprey VLRP response to influenza virus (eLife) * The Biomedical Research Crisis (TWiV 208)
This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses.
Host: Vincent Racaniello and Kathy Spindler
Guests: Tuli Mukhopadhyay, John Patton, and Adam Zlotnick
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Links for this episode * Mukhopadhyay lab * Patton lab * Zlotnick lab * Tuli on Twitter * Palmitoylation of Sindbis virus TF protein (J Virol) * Hepatitis B virus structure (Ann Rev Virol) * Rotavirus RNA polymerase (Curr Opin Virol)
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Theodora Hatziioannou
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Links for this episode * ASU-UofA Joint Virology Symposium * Laboratory of Retrovirology, Rockefeller University * HIV-1-induced AIDS in monkeys (Science) * APOBEC3H bound to duplex RNA (Nat Comm) * Center for HIV RNA studies * Image: Two molecules of APOBEC3H bound to dsRNA
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to **blueapron.com/twiv**.
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks **Theodora -** *To Kill A Mockingbird* by Harper Lee **Kathy** - 25 MILLION Orbeez in a pool
Dickson - Fluid Dynamics of Paint
Rich - The Hitchhiker's Guide to the Galaxy by Douglas Adams
Alan - 30 days at sea: timelapse
Vincent - TWiEVO 24 and Every Time Zone
Listener Picks Fernando - Lego Women of NASA
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus.
Host: Vincent Racaniello
Guests: Katya Heldwein and Sean Whelan
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Links for this episode * Crystal structure of HSV gB (Science) * Crystal structure of HSV fusion regulator gH-gL (Nat Struct Mol Biol) * Nuclear Exodus: Herpesviruses Lead the Way (Ann Rev Virol) * VSV Pseudotypes Bearing gB, gD, gH, and gL (J Virol) * Recovery of infectious VSV from cDNA clones (PNAS) * Structure of the L Protein of VSV (Cell) * Unique strategy for mRNA cap methylation by VSV (PNAS) * Molecular architecture of VSV RNA polymerase (PNAS)
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Truth Wins by Jonathan Yewdell (epub or mobi) * Gabriel Victora awarded MacArthur Prize * Forty Years of mRNA Splicing (CSH) * 2017 Chemistry Nobel: Jacques Dubochet, Joachim Frank, Richard Henderson * 2017 Physiology or Medicine Nobel: Jeffrey C. Hall, Michael Rosbash, Michael W. Young * 2017 Nobel Prize in Chemistry (pdf) * 2017 Nobel Prize in Physiology of Medicine (pdf) * Jonathan Weiner on TWiEVO 19 * RNA methylation modulates plant virus infectivity (PNAS) * Letters read on TWiV 463
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks Kathy - When biospheres collide
Dickson - Blame 10 rivers for ocean plastic
Alan - Farming in The Netherlands
Vincent - Meet the Microbiologist
Listener Picks Jay - OmegaTau podcast
Trudy - Arrowsmith by Sinclair Lewis
Mark - iOS app Human Anatomy Atlas and Master in Business podcast
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.
Hosts: Vincent Racaniello
Guest: David Tuller
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Links for this episode * All of David's ME/CFS articles at virology blog * David Tuller on Twitter * Through the Shadowlands by Julie Rehmeyer
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.
Hosts: Vincent Racaniello
Guest: Phillip A. Sharp
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Links for this episode * Meet the Microbiologist * Sharp Laboratory * Spliced segments of adenovirus late mRNA (PNAS) * Video of this interview (YouTube)
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
Guest: Brianne Barker
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Links for this episode * Meet the Microbiologist * TWiV 1: West Nile Virus * Decreasing readability of scientific texts (eLife) * Measure text readability * Tracing neural circuits with self-inactivating rabies virus (Cell) * Cre driver network (NIH) * Monosynaptic tracing with rabies virus (Neuron) * Letters read on TWiV 461
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks Kathy -Best eclipse video (to date) and solargraph
Dickson - Photos by Will Eades
Brianne - Pale Rider by Laura Spinney
Rich - “Supergenes” Drive Evolution
Vincent -Anatomy of a Moral Panic
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research.
Host: Vincent Racaniello
Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss
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Links for this episode * Cohen Laboratory * Hensley Laboratory * Lopez Laboratory * Weiss Laboratory
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASM Conference on Viral Manipulation of Nuclear Processes * ASM Public Outreach Fellowship * Kymriah approved (PennMed) * CAR T cells (NCBI) * Cost of Kymriah (NYTimes) * Accidental exposure to poliovirus type 2 (Eurosurveill) * GAPIII (WHO) * Poliovaccine candidate in plants (Nat Commun) * Vertical vaccine farm (TWiV 47) * All picornaviruses, all the time (TWiV 425) * Image credit * Letters read on TWiV 459
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks Kathy - Cassini photos
Dickson - Caliber Biotherapeutics
Alan - Grav
Rich - Google street view of the International Space Station (article)
Vincent - the bioinformatics chat
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASM Conference on Viral Manipulation of Nuclear Processes * Roger W. Hendrix, 74 (Pittsburgh Post-Gazette) * Roger Hendrix video on TWiV #135 * Yellow fever in traveler returning from Peru (MMWR) * Dengue subgenomic RNA in mosquito salivary gland (PLoS Path) * Image credit * Letters read on TWiV 458
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks Kathy - Antibody validation Editorial Asilomar meeting report
Dickson - Despommierphotoart.com
Alan - NOAA Hurricane Hunters
Rich - Awakenings by Oliver Sacks (encephalitis lethargica)
Vincent - Goodnight Lab by Chris Ferrie
Listener Picks Pete - Change Agent by Daniel Suarez Paul - Pasteur's Gambit by Stephen Dando-Collins
Maureen - Discovery Documentary First in Human
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guest: Brianne Barker
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Links for this episode * First genetically engineered salmon sold in Canada * Nucleoprotein on influenza virus RNA (Nucl Acids Res) * Evolution of released myxoma virus in Australia (PNAS) * Image credit * Letters read on TWiV 457
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twiv.
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks Brianne - 3D printed viruses
Dickson - Secrets of Schooling
Alan - Making sails in the Nevada desert
Rich - David Vetter isolation suit (Wiki)
Vincent - Confounds the Science
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.
Hosts: Vincent Racaniello and Rich Condit
Guest: Brianne Barker
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Links for this episode * RNA pol III mutations underlie severe varicella (J Clin Inves) * Dengue virus activates cGAS by release of mitochondrial DNA (Sci Rep) * Dengue virus NS2B protein targets cGAS for degradation (Nat Micr) * Image credit * Letters read on TWiV 456
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks Brianne - Up-Goer Five Challenge (related to Thing Explainer)
Rich - The Farthest: Voyager in Space and Vipassana Momma: Science
Vincent - Episode of Revisionist History: The Basement Tapes
Listener Pick Jennie - What Piece of Lab Equipment Are You?
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Erin Garcia
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Links for this episode * DNA-based computer exploit (pdf) * Inactivation of porcine endogenous retrovirus in pigs (Science) * Severe viral respiratory infections in children with IFIH1 mutations (PNAS) * IRF7 deficiency and severe respiratory infection (TWiV 336) * Image credit * Letters read on TWiV 455
This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com
Weekly Science Picks Erin - What If? by Randall Monroe
Rich - Art.Science.Gallery (J. Haley Gillespie) Kathy - Astronomy photographer of the year shortlist
Alan - Upcoming Eclipses
Vincent - Ford Thunderbird Automatic Transmission Rebuild
Listener Pick Bryan - Neuroscientists tricks journals
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guests: Sharon Isern and Scott Michael
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Links for this episode * Hurricane Zika (TWiV 410) * 454 Corporation (Wikipedia) * Regional Zika update, Americas (PAHO, WHO) * Zika virus serum bank (pdf) * Zika virus evolution and spread in the Americas (Nature) * Multiple introductions of Zika virus in US (Nature) * Inhibition of Zika Virus Replication by Wolbachia (J Virol) * Zika virus pathogenesis in rhesus macaques unaffected by immunity to dengue virus (Nat Commun) * Impact of flavivirus immunity on Zika virus infection in rhesus macaques (PLoS Path) * Enhancement of Zika virus pathogenesis by antiflavivirus immunity (Science) * No ADE by dengue antibodies in Zika virus patients (Clin Inf Dis) * Oropharyngeal mucosal transmission of Zika virus in rhesus macaques (Nat Commun) * Letters read on TWiV 454
Weekly Science Picks Dickson - Industrial Scars Kathy - Eclipse info by zipcode
Sharon - Michaela’s article in The Conversation
Scott - Signal P, Pecaan, Phamerator, DNAmaster
Alan - The Eagle Whisperer” (and the Great Big Story channel)
Vincent - Bottle
Listener Pick Kevin - Tenure track scientist bites the dust
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system.
Hosts: Vincent Racaniello and Dickson Despommier
Guest: Diane Griffin
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Links for this episode * Vector-Borne Viruses Symposium * Diane Griffin * Adoptive immunization of immunosuppressed mice infected with Sindbis virus * Role of the immune response in age-dependent resistance of mice to encephalitis due to Sindbis virus * Antibody-mediated clearance of alphavirus infection from neurons * Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis * Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene * Bc1-2 protects mice against fatal alphavirus encephalitis
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv.
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Guest: Lynda Coughlan
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Links for this episode * Linda on Virus Watch and BSGCT * Anti-influenza peptide from frogs (Immunity) * Magainins (Wikipedia) * Urumi * Kathy's defensin paper (PLoS Path) * World Hepatitis Day * Mouse model for hepacivirus infection (Science) * Letters read on TWiV 452
Weekly Science Picks Kathy - US rivers as subway map
Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot Alan - Apollo-era computers found in dead engineer’s basement
Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental
Listener Pick Stig - Security Now! and The Gene by Siddhartha Mukherjee
Ricardo - John Oliver on Vaccines
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * Driving past a milestone (TWiP 100) * Debug Fresno (Verily blog) * What could possibly go wrong? (TWiV 388) * Chestnut blight (ProMedMail) * Hypovirus molecular biology (Adv Virus Res) * Mosquitoes transmit unique WNV populations (Cell Rep) * Teaching science using pseudoscience * Image credit * Letters read on TWiV 451
Weekly Science Picks Kathy - Approaching Jupiter and Michigan parents about vaccination
Rich - Math Limericks from Futility Closet Alan - NASA flyover of Pluto
Vincent - Talk show host nominated as USDA chief scientist
Listener Pick Neil - These smart girls are here to debunk anti-vaxxer nonsense
John - John Sever AMA
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Ben tenOever
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Links for this episode * RNAseIII is an ancient antiviral effector (Nature) * Influenza suppression of RNAi (PNAS) * Questioning mammalian antiviral RNAi (Nat Micro) * Antiviral protection via RdRp (PLoS Path) * Evolution of antiviral defense (Cell Host Micr) * Letters read on TWiV 450
Weekly Science Picks Ben - Invisible Invaders by Peter Radetsky Kathy - ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force
Rich - Columbia river gorge and Undaunted Courage by Stephen Ambrose Dickson - All the World's Earthquakes Alan - Map of Roman roads
Vincent - Brain atlas of fly behavior
Listener Pick Rob - Vaccinate Your Kids and Charles Darwin Natural Selection
Islam - Self-assembling virus and Virus Patterns
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
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Links for this episode * JMBE SciComm Issue * Facial appearance affects science communication (PNAS) * Your face matters to science (virology blog) * RNA based antiviral immunity in mammals (Immunity) * How mice say nodavirus (TWiV 245) * Press release on science meeting gender disparity * The Traditional Lecture is Not Dead. I Would Know – I’m A Professor (virology blog) * Sound of Silence by Disturbed (YouTube) * Letters read on TWiV 449
Weekly Science Picks Kathy - ASV 2017 Virolympics Crossword (pdf) Dickson - The Visible Mouse Alan - Is profitable publishing bad for science?
Vincent - Locally Sourced Science
Listener Pick Neva - Michael Summers interview and Virus coloring book
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Mavis Agbandje-McKenna
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This episode of TWiV is sponsored by Promega Corporation. Promega is a leader in providing innovative solutions and technical support to the life science industry. The company’s 3,500 products support scientists’ worldwide to advance their knowledge in genomics, proteomics, cellular analysis, drug discovery and human identification. Founded in 1978, the company is headquartered in Madison, WI with branches in 16 countries and over 50 global distributors.
Promega products are used by life scientists who are asking fundamental questions about biological processes applying their knowledge to diagnose and treat diseases or discover new therapeutics.
For more information about Promega, visit www.promega.com/ASV
Weekly Science Picks Kathy - Doktor Kaboom! Dickson - Mars as you've never seen it before Alan - Eclipse 2017
Rich - Sirens of Titan by Kurt Vonnegut
Vincent - Research!America
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions!
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * JMBE SciComm Issue * Female role models in engineering (PNAS) * Gender equity at ASM meeting (mBio) * Invisible Frontiers * Time, Love, Memory * The Eighth Day of Creation * Predatory journals recruit fake editor * Photo by Anthony Olszewski * Letters read on TWiV 447
Weekly Science Picks Kathy - Oskar Fischinger Google Doodle Dickson - Ten Tiny But Terrifying Micro Monsters Alan - Hunting mammoth ivory in Siberia
Rich - Occam’s razor
Vincent - Blame vax for illness without proof, says EU
Listener Pick Ed - Lysenkoism
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASM grant writing online course * Gender parity trends at virology meetings (J Virol) * Professor gender perpetuates gender gap (NBER) * Next generation researchers initiative (NIH) * NIH abandons grant cap (Science) * Genesis and pathogenesis of 1918 H1N1 influenza virus (PNAS) * Image credit * Letters read on TWiV 446
Weekly Science Picks Kathy - BioKids Critter Catalog Dickson - Shanghai Vertical Farm Alan - Colossal Cave Adventure open source
Rich - Life on Mars (HI-SEAS)
Vincent - TWiM 154 with Arturo Casadevall
Listener Pick Grant - Antibody validation challenges
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
From Nido2017 in Kansas City, Vincent meets up with three virologists to talk about their careers and their work on nidoviruses.
Host: Vincent Racaniello
Guests: Margo Brinton, Luis Enjuanes, and Linda Saif
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Links for this episode * Murine flavivirus resistance gene (PNAS) * TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) * Infectious coronavirus DNA in BAC (PNAS) * Norovirus binding to lettuce (Appl Env Micro)
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
From ASM Microbe 2017 at New Orleans, Vincent and Rich meet up with astronaut Kate Rubins to talk about becoming an astronaut, space travel, and doing science in space.
Hosts: Vincent Racaniello and Rich Condit
Guest: Kate Rubins
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Links for this episode * Live from the Space Station, NASA Astronaut Kate Rubins * Kate Rubins (NASA, Wikipedia) * Expedition 48-49 launches to the ISS * Expedition 48-49 Crew Docks to the Space Station * Expedition 48-49 Crew Welcomed to the Space Station * Expedition 48 Crew Hands Over the Space Station to Expedition 49 * Photo by Chris Condayan
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging.
Host: Vincent Racaniello
Guest: David Tuller
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Links for this episode * TWiV 397: Trial by Error * All articles by David Tuller at virology blog * Getting it wrong on chronic fatigue syndrome (NY Times) * Esther Crawley slide (Twitter) * David's fundraising page
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiVsters reveal the puppet master: an RNA virus injected with wasp eggs that paralyzes the ladybug so that she protects the cocoon until the adult emerges.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode * ASM grant writing online course * Who is the puppet master? (Proc Roy Soc B) * Why ladybird? * Ladybird ladybird * Dinocampus coccinellae * Image credit * Letters read on TWiV 443
Weekly Science Picks Kathy - Science Showcase Video Contest
Alan - Biochemical pathways on one chart
Rich - 35th America’s Cup
Vincent - Viruses (pdf) and A whole new Jupiter
Listener Pick Peter - Fake typhoid epidemic saves Polish city and Life gets complicated when disease
overruns your town
Ralph - Dilbert on climate change
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Freelance science journalist Tim Requarth joins the TWiVers to explain why scientists should stop thinking that explaining science will fix information illiteracy.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Tim Requarth
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Links for this episode * Neuwrite * JMBE science communication issue * Smallpox vaccination day * The problem with facts (Fin Times) * Countering antivaccination attitudes (PNAS) * Effective messages in vaccine promotion (Pediatrics) * Science curiosity and political information processing (Political Psychol) * Teaching science using pseudoscience (D. Duncan) * Letters read on TWiV 442
Weekly Science Picks Kathy - Life Saver Lightning
Alan - Model rocket engine burning in slow-mo
Rich - scistarter
Vincent - The quest to wipe out a virus and FCC Votes to Begin Dismantling Net Neutrality
Listener Pick Robert - Zika presentation
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Become a patron of TWiV!
Links for this episode * ASM Grant Writing Online Course * Giant viruses not from fourth domain of life (Virology) * Nuclear envelope disruption during parvovirus infection (J Virol) * Nuclear deformation during SV40 infection (Nucleus) * Y chromosome regulates mouse susceptibility to influenza virus (PNAS) * Consomic strains (Mamm Genome) * Giants among viruses (TWiV 261) * Image credit * Letters read on TWiV 441
Weekly Science Picks Kathy - Social science research on “luck” in motherhood
Alan - Foiling dinghy built by engineering students (video)
Rich - Human Exploration Research Analog (HERA)
Vincent - Make measles great again in Michigan and Which tech giant would you drop?
Listener Pick Steven - Difficult truths about a post-truth world
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
No problem being nice to Dickson in this episode, because he's absent for a discussion of a new giant virus that replicates in the cytoplasm yet transiently accesses the nucleus to bootstrap infection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Become a patron of TWiV!
Links for this episode * ASM Microbe * Noumeavirus cytoplasmic replication depends on transient nuclear access (Nat Commun) * Giants among viruses (TWiV 261) * Image credit * Letters read on TWiV 440
Weekly Science Picks Kathy - U-M Rubik’s Cube story #1 video #2 video #3 video
Alan - You're not going to believe this
Rich - High School student builds robot to solve Rubrik's cube
Vincent - NIH limits grant money and The abomination of a bill
Listener Pick Ken - The Fab Lab with Crazy Aunt Lindsey
Laurel - Sally Hoskin’s CREATE program
Maureen - Simple Science Experiments You Can Do With Eggs Before Breakfast
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Paul Bieniasz joins the TWiV team to talk about the co-option, millions of years ago, of an endogenous retrovirus envelope protein by hominid ancestors for host defense against viral infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Paul Bieniasz
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Links for this episode * ASM Grant Writing Online Course * Bieniasz Laboratory * Julius S. Youngner, 96 * Distinguished virology career of Julius S. Youngner (TWiV 373) * Reconstitution of a human ERV (PNAS) * Co-option of ERV envelope for host defense (eLife) * Letters read on TWiV 439
Weekly Science Picks Kathy - UM Science Communication TeachOut
Alan - LLNL nuclear test videos
Rich - The Great A.I. Awakening (Artificial neural network; DeepDream; DeepDream images) Dickson - Cassini images
Paul - Howard Hughes Medical Institute
Vincent - Google rewrites search rankings; Senator Whitehouse on politics of climate change
Listener Pick Anthony - Raspberry Pi 3 Model B Weather Monitor Kit
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Guests: Stefano Bertuzzi and Susan Sharp
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Links for this episode * Journal of Microbiology & Biology Education sci comm issue * ASM Cultures * Stefano Bertuzzi and the scientists' big picture (Washington Post) * March for Science * The March for Science (NY Times) * I have always marched for science (virology blog) * A scientist who studies marches on the March (Atlantic) * What exactly are people marching for (Atlantic) * Explaining science won't fix information illiteracy * Letters read on TWiV 438
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Weekly Science Picks Alan - Steve Ballmer’s government data project (NYTimes article)
Rich - Alexander Hamilton by Ron Chernow Dickson - Shanghai vertical farming
Vincent - Right-to-try sham and NASA media
Stefano - Why Religion is Natural and Science is Not and The Path Between the Seas
Susan - Rick and Morty
Listener Pick Johnye - A capella CRISPR/Cas9
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
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Links for this episode * Journal of Microbiology & Biology Education sci comm issue * Mark Wainberg dies * Giant viruses with many translation system components (Science) * Viruses in the oceanic basement (mBio) * 2-back test * Photo by Judy * Letters read on TWiV 437
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science Picks Kathy - Cloud appreciation society
Rich - High Rise Urban Farming Dickson - Planets orbiting a distant star
Vincent - TWiEVO 18: Raiders of the lost orco
Listener Pick Kevin - Cherry blossoms at Brooklyn Botanical Garden
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guests: Susan Daniel, Colin Parrish, and Gary Whittaker
At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals.
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Links for this episode * Daniel Laboratory * Parrish Laboratory * Whittaker Laboratory
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque.
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Links for this episode * ASM Grant Writing Course * Screwworm letters * Blood DNA virome of 8,240 humans (PLoS Path) * Plaque co-infection frequencies (mBio) * Ode to a plaque (TWiV 68) * Counting viruses (Virus Watch) * First animal virus plaque assay (J Exp Med) * Letters read on TWiV 435
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science Picks Alan - Couple donates insect collection Kathy - Why is science important to you?
Rich - Hook Dickson - Ten Incredible Astronomy Pictures
Vincent - Why Trump’s NIH Cuts Should Worry Us and
The Real Threat to National Security: Deadly Disease
Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host.
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Links for this episode * ASM Microbe 2017 * Parasitoid wasp virus regulates sex ratio (PLoS Path) * What is a contig? * Image credit * Letters read on TWiV 434
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science Picks Alan - The Wrath of Khan from Bug Chicks Kathy - Boaty McBoatface submarine launching
Dickson - Fierce animal portraits
Vincent - Westworld
Listener Picks Hannah - Plague, Inc
Stig - John Oliver: Trump vs the truth
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans.
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Links for this episode * ASM Clinical Virology Symposium * Evolution of the human fecal virome (PNAS) * Antiviral RNAi response in C. elegans (Curr Biol) * Orsay virus (TWiV 123) * Broad VSV host range (J Comp Neurol) * Image credit * Letters read on TWiV 433
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science Picks Alan - Contact information for Senators and Representatives Kathy - How Tumor Virology Transformed Oncology
Dickson - Seven new species of Peacock Spider
Vincent - Proposed NIH budget cut and Expensive Oxford Comma
Listener Pick Kim - Pigeon Fashion Week (TWiEVO 7)
Richard - aeroMorph and Understanding Molecular Evolution
Johnye - Ice Instruments and Fahrenheit and Celsius
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses.
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Links for this episode * Nido2017 Meeting * ASMCUE * Seroprevalence of Zika virus in wild monkeys and baboons (mSphere) * Zika virus mRNA vaccines (paper one, paper two) * Gamete fusion protein is type II viral fusogen (paper one, paper two) * Image credit * Letters read on TWiV 432
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science Picks Alan - Raspberry pi Kathy - The Worst F&#%ing Words Ever
Dickson - NASA images of climate change
Brianne - How herd immunity works
Vincent - Radioactive boars in Fukushima
Listener Pick
Margaret - DNA socks and gloves
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak.
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Links for this episode * Nido2017 Meeting * ASM Microbe 2017 * Mark Buller obituary * RS virus pipeline (pdf) * Prophage WO genes and cytoplasmic incompatibility (Nature) * Vanderbilt Virology (TWiV 332) * Basis for increased Ebolavirus glycoprotein activity (Cell Host Micr) * Letters read on TWiV 431
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Weekly Science Picks Rich - Germ Theory by Robert P. GaynesAlan - Student Scientist Partnerships Kathy - Symbiartic
Dickson - PaleoBioDB Navigator
Vincent - Kusama Infinity Room
Listener Pick Chaim - How to fight back against the backfire effect
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency.
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Links for this episode * Nido2017 Meeting * ASM Clinical Virology Symposium * Zika virus sexual transmission in mice (Cell Rep) * Viral RNA is not infectious virus (virology blog) * Methyl-phospho switch (TWiV 369) * Immune escape of herpesvirus from latency (Cell Rep) * Restarting lytic gene expression (J Virol) * Letters read on TWiV 430
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Weekly Science Picks Rich - Vipassana Momma (Dravet Syndrome) Kathy - Landlines Chrome Experiments
Dickson - Origami Revolution
Vincent - Hunched Over a Microscope
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guests: Katie Antony, Tom Friedrich, Emma Mohr, and David O'Connor
Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis.
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Links for this episode * Badgers Go Viral (TWiV 260) * Rhesus macaque model of Zika virus infection (Nat Commun) * Heterologous Zika virus protection in macaques (PLoS NTD) * ZEST Data Portal
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection.
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Links for this episode * Nido2017 Meeting * Superspreader bacteriophages (mBio) * Astrocytes, interferon, and viral infection (JCI) * Viral disruption of blood brain barrier (Trends Micro) * On Warts by Lewis Thomas (pdf) * Letters read on TWiV 428
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv
Weekly Science Picks Alan - Skulls Unlimited
Rich - Bernard Moss Reflection Kathy - Why vaccines don't cause autism
Dickson - Honomobo
Vincent - Trump vs FDA
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello Guest: Vincent Munster
At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses.
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Links for this episode * Rocky Mountain Laboratory * Munster Laboratory * Small town, big science (TWiM 140) * Image credit
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus.
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Links for this episode * ASM 2017 election is now open - VOTE HERE * ASM Election questions: + Which positions are we voting for? + What is the ASM Board of Directors? Organization Chart + What is the Council on Microbial Sciences? Organization Chart + FAQs * Scientists' march is bad idea (NY Times) * GOF moratorium lifted (Archived White House) * VSV gene order (PNAS) * VSV gene order later (PNAS) * Letters read on TWiV 427
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Weekly Science Picks Alan - Good Omen miniseries (book)
Kathy - How to cure earworms
Dickson - Exoplanets orbits
Vincent - Outbreak News Today
Listener Pick Tom - The Smartest Protester
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells.
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Links for this episode * Register for ASV 2017 * ASM 2017 election is now open - VOTE HERE * ASM Election questions: + Which positions are we voting for? + What is the ASM Board of Directors? Organization Chart + What is the Council on Microbial Sciences? Organization Chart + FAQs * Scientists March on Washington * Spontaneous generation of unique cervid strain (mSphere) * Zika virus entry into human glial cells via Axl (Cell Rep) * Article collections: PNAS, Cell, Nature, Virology * Letters read on TWiV 426
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv.
Weekly Science Picks Alan - Deerland by Al Cambronne
Dickson - Antarctica's Colorful Underwater World
Kathy - You can’t unring a bell #1 and #2
Rich - Extra letters added to life's genetic code (source) and The Doomsday Clock (wiki)
Vincent - Trump Science Advisors, National Parks Won't Be Silenced
Listener Pick Stefan - The Vital Question by Nick Lane
Kevin - Scientists March on Washington?
Dennis - Fractal Tree of Life
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection.
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Links for this episode * Register for ASV 2017 * ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens * XKCD #242 * Thermostable poliovirus empty capsid vaccine (PLoS Path) * Switch between viral entry and clearance (Nature) * Glass poliovirus by Jason Roberts * Letters read on TWiV 425
This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv.
Weekly Science Picks Alan - Medical lab whirligig
Dickson - Antarctica's Colorful Underwater World
Kathy - Prince Rupert’s drops #1 and #2
Rich - Dylan's 30th - Eric Clapton --Don’t Think Twice, It’s All Right (The 30th Anniversary Concert Celebration)
Vincent - Saving climate data and Public Good and Public Funding of Science
Listener Pick Suellen - For the anti-vaccine people
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Trudy Rey
Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago.
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Links for this episode * Welcome omega tau to MicrobeTV * Register for ASV 2017 * Oliver Smithies dies * Assays for prions in the blood (one, two) * Biosafety working on prions (Michigan State) * Marine origin of retroviruses in Palaeozoic era (Nature Comm) * Cancer Virus by Dorothy Crawford * Adenovirus and obesity (Int J Chronic Dis) * Image credit * Letters read on TWiV 424
Weekly Science Picks Trudy - Artist Jenni Viljaniemi Alan - Radio Garden
Dickson - World's First Green Energy Boat
Kathy - mSphereDirect video and web
Rich - Deathworld Trilogy by Harry Harrison
Vincent - Trump's Vaccine Panel (NYTimes), Offit's Response (Daily Beast), ASM Letter
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jared Rice
The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats.
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Links for this episode * Register for ASV 2017 * ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens * Astrovirus capsid protein induces diarrhea (mBio) * Fungal virus associated with white-nose syndrome (PLoS Path) * Image credit * Letters read on TWiV 423
Weekly Science Picks Alan - GPS visualizer
Dickson - James Webb Space Telescope and The Vertical Farm
Kathy - First Snowflake Photos (One and Two)
Rich - Red Mars by Kim Stanley Robinson
Vincent - Carrie Fisher Fought for the Rebel Alliance and Mental Health Awareness
Listener Pick Ken - The Abate Lab
Sean - The Death of Expertise
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories.
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Should auld infections be forgot
And never T-cells primed?
Will cross-reacting antigens
Protect the host next time?
Links for this episode * Register for ASV 2017 * ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens * Ten virology stories from 2016 + Zika virus (first covered in 2015, TWiV 368) + Ebolavirus + Eukaryotic genes in Wolbachia phage (TWiV 412) + Harold "400" Varmus (TWiV 400) and many other guests + Vaccines + Mutualism + Mosquitoes and viruses + Vector victorious (TWiV 401) + Animal models of virus infections + Virus evolution * Current Zika virus infections (ECDC) * Early Zika virus infections in Hawaii (PLoS NTD) * Zika virus vaccine for whom? (NYTimes) * Final results for Ebola virus vaccine (Lancet) * Photo from Mohammad * Letters read on TWiV 422
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Weekly Science Picks Alan - North America's Lost Medieval City
Dickson - New Views of Pillars of Creation
Kathy - Reilly Top Ten
Rich - Everyday Einstein
Vincent - Naples' Sleeping Volcano Might Be Waking Up
Listener Pick John - RadioLab: The Times They Are a-Changin'
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Nathan Letts
The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.
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Links for this episode * Register for ASV 2017 * ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens * Chikungunya virus vaccine using insect virus platform (Nat Med) * Ebola vaccine results (NYTimes, paper) * Letters read on TWiV 421
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Weekly Science Picks Alan - Open Access Button
Dickson - National Geographic Photographs
Kathy - World's Tiniest Radio Receiver
Nathan - Mutter Museum, Philadelphia
Vincent - How Rogue One is Connected to the Mac
Listener Pick Sam - Cell Lab: Evolution Sandbox
Hannelore - Congressional Dish
Johnye - The Fungi in Your Future
Brendan - Zimmer on Longform podcast
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.
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Links for this episode * Register for ASV 2017 * Local Zika virus transmission in Texas * Texaszika.org * Local dengue virus transmission in Texas (EID) * No more Zika virus transmission in Florida (FL DOH) * Dengue virus antibodies enhance Zika virus infection (Clin Trans Imm) * Infectious, replication incompetent influenza virus vaccine (Science) * Pyrrolysl-tRNA synthetase (Biochem Biophys Acta) * History of nonsense suppression (Stan Maloy) * Suppression of poliovirus amber mutant (Cell) * Remembering mumps (PLoS Path) * Letters read on TWiV 420
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Weekly Science Picks Alan - Superbugs game
Dickson - Dinosaur tail trapped in amber
Rich - Earth's Rotation is Slowing (original article)
Kathy - Lithium Ion batteries (one and two)
Vincent - Truth and Lies in the Age of Trump (virology blog) and self driving Uber car
Listener Pick Steve - New York City Street Tree Map
Justin - Transmissible vaccines?
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus.
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Links for this episode * Microcephaly associated with Zika virus infection in Colombia (MMWR) * Virophage genome integration and activation by superinfection (Nature) * Don Nelson interview (pdf) * Page view and h index for paper rank (PLoS One) * Credit for image of C. roenbergensis * Letters read on TWiV 419
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Weekly Science Picks Alan - Lab Wars
Dickson - Star in a Jar Fusion Reactor
Rich -You're a Bee. This is What it Feels Like.
Kathy - List of Potential Predatory Journals
Vincent - CRISPR Patent Trial Begins
Listener Pick Drake - Spinzall
Katreya - Periodic Videos
Pritesh - Smallpox in mummy
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor.
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Links for this episode * New mouse model for MERS (Nat Micro) * RNA-guided genome engineering (Science) * Photo by Finny * Letters read on TWiV 418
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 27:50
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Register for ASV 2017 at Madison, Wisconsin
Weekly Science Picks Alan - Human population through time
Dickson - Every Orbit Cassini Has Taken
Rich - OK GO: Walk Her Walk
Kathy - Medieval Bestiary Online
Vincent - Can You Out-Science an Eighth Grader? and Stitchen Pox
Listener Pick Hannah - Bioart and Bacteria
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guest: Gary Nabel
Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines.
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Links for this episode * World AIDS Day * Video of this interview (YouTube)
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero.
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Links for this episode * WHO: Zika virus is no longer a PHEIC * World AIDS Day * Early HIV/AIDS history in North America (Nature) * Dugas was not AIDS patient zero (virology blog) * Image credit * Letters read on TWiV 417
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm
Register for the 2017 ASM Grant Writing Online course.
Weekly Science Picks Alan - VP8SGI
Dickson - New leaf-shaped spider discovered
Rich - Dance of Earth and Venus About the Sun
Kathy - Cultivar Series, Mutatoes, Uli Westphal site
Vincent - Kung Fu Mantis vs Jumping Spider
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!).
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Links for this episode * Predators allow virus infection of endosymbiont (PNAS) * Image credit * Letters read on TWiV 416
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:34:40
Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 5:05
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Weekly Science Picks Alan - Cubes in Space
Dickson - The Architecture of Eden by H. Pearlman and A. Whalley
Rich - Studying the building blocks of life in stereo (original paper)
Kathy - Ancient bottom wipes yield evidence of diseases (original paper)
Vincent - Iguana vs snakes
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Jeremy Luban, Aaron Lin, and Ted Diehl
Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.
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Links for this episode * Ebola virus glycoprotein with increased infectivity (Cell) * Effect in cells of Ebola virus mutations from West African outbreak (Cell) * Ebola virus in semen for over 500 days (Clin Inf Dis) * Puzzling origin of 2014 Ebola virus outbreak (J Virol) * Mutant Ebola virus may have caused explosive outbreak (Goats and Soda) * Virus Genomics and Evolution website
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:05:40
Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35
Register for the 2017 ASM Grant Writing Online course.
Weekly Science Picks Jeremy – Real time tracking of Ebola virus evolution
Ted - The Brain Scoop
Aaron - Kate Rubins sequencing DNA on ISS (video)
Alan – A Sand County Almanac by Aldo Leopold
Rich – Vendee Globe
Kathy – Axios
Vincent – Vendors from above by Loes Heerinck
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guest: Michael Diamond
Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication.
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Links for this episode * Chikungunya virus chronic joint disease caused by adaptive response (J Virol) * Mouse model of Zika virus pathogenesis (Cell Host Micr) * Zika virus infection during mouse pregnancy (Cell) * Zika virus infection damages mouse testes (Nature) * Uveitis and Zika virus in tears in mice (Cell Rep)
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm
Register for the 2017 ASM Scientific Writing and Publishing Online Course.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex
Guests: Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry
From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases.
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Links for this episode * EIDA2Z meeting * MERS-CoV infection of Alpaca (EID) * Origins of HAV in small mammals (PNAS) * WHO recommendations on influenza vaccine composition * Collaborative Cross mice * Video of this episode at YouTube
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Mark Fuccio
The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia, and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell.
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Links for this episode * Zika virus in vaginal secretions (EID) * Zika virus in semen (EID) * Eukaryotic genes in a bacteriophage (Nat Commun) * Seth Bordenstein on TWiV 332 * DNA tumor virus oncogenes antagonize cGAS-STING (Science) * Letters read on TWiV 412
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Mark - EFN Enterprise Futures Network and Mission Log Podcast Alan - 2016 Wildlife Comedy Photography Rich - ZuTA, portable robotic printer
Kathy - How LEGO help blind people see Vincent - Airplane photos of Mike Kelley
Listener Pick Hannah - Frozen Flow Glass (Instagram)
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses.
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Links for this episode * MicrobeTV Store * Florida DOH Daily Zika Update * Zika virus in new Miami neighborhood (CNN, NYTimes) * NDV vaccine virus in wild birds (PLoS One) * Protein cell receptor for murine norovirus (Science, PNAS) * Poliovirus receptor analysis (J Virol) * Letters read on TWiV 411
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - Braincraft Rich - Now is the Greatest Time to Be Alive
Kathy - CRISPR/Cas9 by A Capella Science Vincent - Microbes After Hours: The Necromicrobiome
Listener Pick Jolene - Chalk Talk Science by Dennis Mangan
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Guests: Sharon Isern and Scott Michael
Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.
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Links for this episode * Live at Florida Gulf Coast University (TWiV #111) * Florida DOH Daily Zika Update * Regional Zika update, Americas (PAHO, WHO) * NJ Zika Bill * Dengue virus antibodies enhance Zika virus infection (bioRxiv) * First detection of Zika virus in Brazilian A. aegyptii (Mem Inst Oswaldo Cruz) * 2017 ASM Scientific Writing and Publishing Online Course * Letters read on TWiV 410
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Sharon - Zika virus comics and cartoons and Florida weekly arbovirus reports
Scott - Real-time tracking of Zika virus evolution
Alan - Evolution of antibiotic resistance on a mega plate Rich - Windytv
Kathy - Zika virus map and timeline Vincent - Ohsumi Nobel advanced information and HR 5325 funding breakdown
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Jeremy Luban
Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.
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Links for this episode * No recovery in PACE trial (virology blog) * The real PACE data (virology blog) * Contagious Thinking * Florida DOH daily Zika update * Congress does not fail on Zika (NPR) * Nef history (Luban lab) * Nef excludes SERINC from virions (Nature) * SERINC counters Nef (Nature) * ASM Grant Writing Online Course * Letters read on TWiV 409
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 28:50
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - Migration in Motion
Dickson - Beautiful Chemistry
Rich - XKCD Timeline of Earth Temperature Kathy - Vaccine Heroes from Vaccine Education Center
Jeremy - CIDRAP posters andDemon in the Freezer Vincent - People Peas and Pathogens
Listener Picks Matlock - Science isn't broken
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello and Alan Dove
Guest: David Quammen
Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.
Watch this episode at YouTube
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Links for this episode * David Quammen's website * Spillover by David Quammen * Threading the NEIDL (TWiV 200) * The NEIDL at Boston University
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guests: Ralph Baric, Kristina De Paris, Tal Kafri, Helen Lazear, Mark Heise, and David Margolis
In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.
View video of this episode at YouTube
Become a patron of TWiV!
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guests: Dirk Dittmer, Cary Moody, Nat Moorman, Nancy Raab-Traub, Lishan Su, and Jennifer Webster-Cyriaque
In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists.
View video of this episode at YouTube
Become a patron of TWiV!
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids.
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Links for this episode * Florida DOH daily Zika update * Congress fails again on Zika (NY Times) * Culex pipiens does not support Zika virus replication (EID) * Zika virus in the eye (Cell Rep) * Norovirus replication in enteroids (Science) * Norovirus replication in B cells (TWiV 312) * Baylor press release * Norovirus replication in B cells confirmed (Antiviral Res) * Letters read on TWiV 406
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - Infective Perspective
Dickson - The Living River
Rich - Freddy Mercury around the Sun Kathy - A Day in Pompeii
Vincent - Spraying Pesticides
Listener Picks Ricardo - Why the metric system matters
Eric - The Giving Plague by David Brin
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data.
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Links for this episode * Roger Tsien, 64 (UC San Diego Health) * CDC running out of Zika money (NYTimes) * Zika virus in Miami mosquitoes (NYTimes) * No Zika virus in Rio Olympics (NYTimes) * Vertical transmission of Zika virus in Aedes aegypti (AJTMH) * Uncovering Earth's virome (Nature) * Image credit (Global water volume) * Letters read on TWiV 405
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 58:55
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - The Vizzies
Dickson - NASA Spinoff Kathy - Maps.me
Vincent - Zika: The Emerging Epidemic by Donald McNeil
Listener Picks Tarwin - Darwin's Radio by Greg Bear (paper or Kindle)
Bodham - The start of scientific publishing, 1665
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.
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Links for this episode * FluMist problem (FDA) * DA Henderson obituary (NY Times) * DA Henderson, smallpox eradicator (TWiV Special) * Efficacy of VZV vaccine (Ther Adv Vaccines) * Zika virus burden, Puerto Rico (JAMA) * Zika virus in Miami Beach (STAT) * Congenital brain anomalies and Zika virus (Radiology) * Congenital Zika syndrome with arthrogryposis (BMJ) * Multicomponent animal virus from mosquitoes (Cell Host Microbe) * Breaking rules of infection (NPR) * Image credit * Letters read on TWiV 404
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - Sally Le Page
Dickson - Comfortably Numb by Jamie Dupuis Rich - Learned Helplessness
Vincent - Virus by Marilyn Roossinck
Listener Picks OneTime - The Stranglers - Old Codger
Steve - A Poem About Pronunciation
Send your virology questions and comments to twiv@microbe.tv
Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio.
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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.
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Links for this episode * Tribunal orders release of PACE trial data (Valerie Eliot Smith) * Our request for PACE trial data (virology blog) * GM mosquito release on ballot (NPR) * Florida Keys Mosquito Control District on TWiV #111 * Cold chain and virus free plant based polio vaccine (Plant Biotechnol J) * Disappointing flu vaccine effectiveness (CBC) * ACIP votes down use of LAIV (CDC) * LAIV as effective as inactivated flu vaccine (Ann Int Med) * Flumist does work (NPR) * Declining effectiveness of zoster vaccine (J Inf Dis) * Efficacy of adjuvanted subunit zoster vaccine (NEJM) * Risk of zoster from vaccine (J Inf Dis) * Image credit: ViralZone * Letters read on TWiV 403
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - To Scale: The Solar System
Rich - Route 66 Goes Solar
Vincent - Race for a Zika Vaccine by Siddhartha Mukherjee
Listener Picks Bohdan - Penn and Teller on Vaccinations
Bill - Connections, Episode 1
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV.
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Links for this episode * Marian Horzinek, 80 (ProMedMail) * Polio in Nigeria (Atlantic, Stat, ProMedMail) * Zika virus spreads in Miami (NYTimes) * More Zika virus vaccines (Science) * Back to work on Zika, Congress ! (Asbury Park Press) * Lack of funding will stymie Zika vaccines (Wash Examiner) * FDA OK on genetically modified mosquitoes (FDA) * CMV attracts aphid vectors (TWiV #70) * CMV attracts pollinating bumblebees (PLoS Path) * Earth dwarfed by solar flare (jpg) * Letters read on TWiV 402
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - Solar storm that launched US space weather science
Rich - Data storage on DNA
Dickson - Perseid meteor show live
Vincent - In the Company of Microbes by Elio Schaechter
Listener Picks Neva - I Contain Multitudes by Ed Yong
Amanda - American Gut
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy.
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Links for this episode * Beverly Griffin, 86 (1 2 3) * Zika virus in the US (CDC) * Zika virus spreading in Miami (CDC) * Zika virus in Florida (NY Times) * NIH begins phase I trial of Zika virus DNA vaccine (NIAID) * Mosquito salive enhances West Nile replication in mice (J Virol) * Mosquito bites enhance virus infection (Immunity) * Photo of A. aegyptii and mouse ears from Marieke Pingen * Letters read on TWiV 401
This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.
Weekly Science Picks Alan - The Doubleclicks
Kathy - WHO ZIKV app and ZIKV Giant Microbe
Dickson - Photographer Rosamond Purcell
Vincent - Spillover: Zika, Ebola, and Beyond
Listener Picks Ricardo - Portugal Four Days on Renewable Energy
Fatma - DeNovo: Predicting virus-host protein interactions
Stephen - How mosquitoes use six needles to suck your blood
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Harold Varmus
The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science.
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Links for this episode * Varmus Laboratory * Varmus and Kandel on Charlie Rose (transcript) * Rescuing biomedical research * Letters read on TWiV 400 * Video of this episode at YouTube
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
This episode was made possible by PLoS Pathogens - the leading Open Access journal to publish breakthroughs in understanding pathogens and their interactions with host organisms and each other. PLOS Pathogens fosters the open exchange of ideas across fields, publishing original research on viruses, bacteria, fungi, parasites, and prions. For more information, check out www.plospathogens.org
Weekly Science Picks Alan - A year on Earth
Rich - TWiV #1: West Nile Virus
Dickson - Chasing storms, chasing beauty
Kathy - Bioartography and FASEB image and video competition
Vincent - The Art and Politics of Science by Harold Varmus (free download)
Listener Picks Trudy - Scientific Studies on Last Week Tonight with John Oliver
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta.
Links for this episode * Zika virus disease in the US (CDC) * Female to male Zika virus transmission (CDC) * Zika virus in female genital tract (Lancet) * Zika virus transmission in Utah (CDC and NYTimes) * Olympic Zika virus risk (CDC) * 15 companies on Zika virus vaccines (WSJ) * Zika virus DNA vaccine in mice (Nature) * Zika virus disease in Colombia (NEJM) * Dengue virus antibody dependent enhancement of Zika virus (PNAS) * Zika virus antibodies enhance dengue virus disease (Science) * Zika virus in human placenta and developing brain (bioRxiv) * Zika virus targets different human placenta cells (Cell Host Microbe) * Letters read on TWiV 399
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Become a patron of TWiV.
Weekly Science Picks Alan - CDC postmortem on Ebolavirus outbreak
Rich - Refutations to anti-vaccine memes (Twitter, Facebook)
Dickson - History of urbanization
Vincent - How to cut subject from background in Photoshop
Listener Picks Marion - Skeptics Guide to the Universe podcast
Jennie - Leatherback turtles in Costa Rica
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Host: Vincent Racaniello
Guest: Sandy Weller
Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes.
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Links for this episode * Cell killing by avian leukosis virus (Sandy's first paper, J Virol) * ND10 protein and herpes simplex virus replication (J Virol) * Recombination promoted by DNA viruses (Ann Rev Micro) * HSV-1 and DNA damage response (Fut Virol) * Video of this episode at YouTube
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guest: David Tuller
Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.
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Links for this episode * Science and journalism (TWiV 111) * Chronic fatigue syndrome and the CDC (virology blog) * PACE trial (Lancet) * Trial by error part one, two, three (virology blog) * PACE economics analysis (PLoS One) * All articles by David Tuller at virology blog * Valerie Eliot Smith's blog * Karina Hansen, prisioner of Denmark
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guest: Peter Palese
Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.
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Links for this episode * Palese Laboratory * Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem) * DNAse in cytoplasmic DNA virus (Virology) * Inhibitor of influenza virus neuraminidase (Virology) * Influenza neuraminidase defective mutants (Virology) * Swine influenza virus of 1976 RNA pattern (Nature) * 1977 influenza H1N1 similar to 1950s strains (Nature) * H5N1 influenza: Facts, not fear (PNAS) * Influenza HA stalk immunity in ferrets (J Virol)
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Stephen J. Russell
From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers.
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Links for this episode * Hokies go viral (TWiV 285) * MV NIS de Myelo (TWiV 298) * Remission of disseminated myeloma after MV treatment (Mayo Clin Proc) * miRNA detargeting (J Virol) * Video of this episode at YouTube
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Weekly Science Picks Kathy - Can you explain your science in 30 seconds? and How Far Can We Go?Rich - Small asteroid Earth's companion
Vincent - The Gene by Siddhartha Mukherjee
Listener Picks Dylan - Microsculpture by Levon Biss (website)
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello and Alan Dove
Guest: Erica Ollmann Saphire
Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.
Become a patron of TWiV!
Links for this episode * Structure of antibodies bound to Ebola virus glycoprotein (PNAS) * Structure of cross-reactive filovirus antibody (Cell) * Multiple functions of Ebola virus VP40 protein (Cell) * View video of this episode on YouTube * Letters read on TWiV 394
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Weekly Science Picks Alan - Slime Lapse
Vincent - Virus Watch
Listener Picks Patricia - NECSS, People Behind the Science, The Life Scientific
Peter - Iron Lung on eBay
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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.
Become a patron of TWiV!
Links for this episode * Late sexual transmission of Zika virus (Lancet) * Zika virus disease in US (CDC) * Zika virus lab accident (ABC News) * Mosquito eradication (virology blog) * Florida mosquito control (TWiV 111) * How tequila mosquito (TWiV 178) * SEC14L2 allows HCV replication in cell culture (Nature) * Lipid peroxidation (Wikipedia) * HCV replicase regulated by lipid peroxidation (Nat Med) * Letters read on TWiV 393
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Also brought to you by ASV 2016
Weekly Science Picks Alan - All About That Space
Rich - The Expanse by James S.A. Corey (SyFy)
Kathy - Five Pivotal Paragraphs in a Paper
Vincent - Agar Art Contest Winners
Listener Picks Ted - Marshall Niremberg charts
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Host: Vincent Racaniello
Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice
Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC.
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This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Guests: David Pride and Forest Rohwer
If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool.
Links for this episode * Lytic to temperate switching of viral communities (Nature) * Viromes in ancestral holobiont Hydra (PLoS One) * Phage in human oral cavity (J Oral Micro) * Human oral viruses are personal, consistent, gender specific (ISME) * Video of this episode at YouTube
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Weekly Science Picks Alan - Vax Pack Hero
Rich - Helicopter autorotation
Vincent - Live in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa
Listener Picks Matt - Experiment.com
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Ethan Jackson and Jonathan Carlson
Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan.
Links for this episode * Project Premonition * Premonition feasibility study in Grenada * Zika virus causes microcephaly in mice (Cell Stem Cell) * Brazilian Zika virus causes defects in experimental models (Nature) * Zika virus causes placental damage and fetal demise in mice (Cell) * Letters read on TWiV 390
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Also brought to you by ASV 2016
Weekly Science Picks Dickson - Germany nearly reached 100% renewable power Alan - Vertical City documentary and Lumino City game
Rich - Errol Morris: ‘Demon in the Freezer’
Kathy - Entropic Time YouTube by A Capella Science (watch “the making of”)
Vincent - Agar Art contest finalists
Listener Picks Jennie - SciFi reading (scroll down)
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Host: Vincent Racaniello
Guest: Stan Lemon
Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses.
Links for this episode * Live in Edmonton, Eh? (TWiV 235) * Replication of EBV in epithelial cells (Nature) * Returning to Carolina after 14 years * Evolutionary origins of hepatitis A virus (TWiV 265) * cre in rhinovirus genome (RNA) * Naked viruses that aren't always naked (Ann Rev Virol) * miR-122 and hepatitis C virus RNA (Cell Host Micr)
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy.
Links for this episode
- biorXiv preprint server
- Please review Vaccines and Your Child
- Structure of antibody bound to Zika virus E protein (Cell Host Microbe)
- Wolbachia blocks Zika virus in mosquitoes (Cell Host Microbe)
- Zimmer on Wolbachia and Zika virus (NY Times)
- Fauci on Zika virus vaccine (Science)
- Carpageddon (The Conversation)
- Letters read on TWiV 388
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Also brought to you by ASV 2016
Weekly Science Picks Dickson - EarthEnv Alan - Research funding by lottery
Kathy - Eugenia Cheng Math and Baking
Vincent - Zika Diaries
Listener Picks Stephen - Virus trading cards
William - Virus trading cards
Norma+Maurice - Virus trading cards
Tom - Virus trading cards
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Nina Martin
Nina Martin joins the TWiV team to talk about the movie Vaxxed, her bout with dengue fever, and the latest research on Zika virus.
Links for this episode * Public Health United * Fifty Shades of Science (TEDx) * Parents convicted in death of toddler (Science Based Medicine) * CDC: Zika virus causes microcephaly (NEJM) * Dengue virus antibodies enhance Zika virus infection (biorXiv) * Zika virus in Brazilian nonhuman primates (biorXiv) * Zika virus IgM in CSF of microcephalic babies (Lancet) * Brain organoids for modeling Zika virus infection (Cell) * Letters read on TWiV 387
This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.
Also brought to you by ASV 2016
Weekly Science Picks Nina - Vaccines and Your Child by Paul Offit and Charlotte MoserDickson - The animals of Chernobyl Alan - Five rules of lab safety
Kathy - 20
best science images of the year?
Vincent - Massive undersea crab swarm
Listener Picks JP - Global map of wind
Todd - Doc Martin
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ted Diehl and Welkin Johnson
Ted and Welkin inform the TWiV team how the evolution of ancient retroviruses can be inferred by studying their sequences in the genomes of modern mammals, and join in a discussion of virus dispersal during different methods for drying hands.
Links for this episode * More fun than a monkey full of viruses (TWiV 122) * Tracking ancient retrovirus evolution in mammals (eLife) * Virus dispersal during hand drying (J Appl Micro) * More than you wanted to know about hand drying (one, two, three, four, five, six)
This episode is sponsored by ASM Agar Art Contest, ASM Grant Writing Course, and ASV 2016
Weekly Science Picks 1:30:20
Welkin - Lab Girl by Hope Jahren (essay)
Ted - Accidental brilliance in scienceRich - Perpetual motion?
Kathy - R0 graphic and explanation
Vincent - NWS ditches all caps forecasts
Listener Picks
Basel - Gimli Glider and Mars Climate Orbiter
Ken - Vaccination comic book
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Hosts: Vincent Racaniello and Dickson Despommier
Guest: Stuart Firestein
Stuart joins Vincent and Dickson to talk about his sequel to Ignorance, a book called Failure, which seeks to make science more appealing by revealing its faults.
Links for this episode * Stuart Firestein's site * Ignorance with Stuart Firestein (TWiV Special) * The pursuit of ignorance (TED) * Ignorance by Stuart Firestein * Failure by Stuart Firestein
This episode is sponsored by ASM Agar Art Contest and ASV 2016
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Rich Condit
Guests: Nischay Mishra and Ian Lipkin
Nischay and Ian join the TWiVions to discuss mass die-offs of tilapia by a novel orthomyxo-like virus, Ian's editorial on the movie Vaxxed, and new vaccines to prevent dengue virus infections, including a human challenge model.
Links for this episode * Novel orthomyxo-like virus in Tilapia die-offs (mBio) * Fish flu (TWiV 41) * Anti-vaccination lunacy won't stop (WSJ) * Single-dose dengue vaccine effective (J Inf Dis) * Dengue vaccine needs (J Inf Dis) * Composition of TV003 (J Inf Dis) * Dengue vaccine mutagenesis (Curr Top Micr Imm) * Dengue human challenge model (Sci Transl Med) * Yellow fever alarm (STAT) * Experiment: Zika virus * UC Berkeley Microbiology Student Symposium * Image credit * Letters read on TWiV 384
This episode is sponsored by ASM Agar Art Contest, ASM Grant Writing Course, and ASV 2016
Weekly Science Picks
Rich - Dune by Frank HerbertAlan - Adult vaccination video contest
Dickson - Ski town greenhouse
Vincent - Preprint servers: Force awakens or revenge of undead?
Listener Picks
Ken - Golden Mole Awards for Accidental Brilliance (list, video)
Jim - Linear algebra course
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler
Guest: Esper Kallas
Esper and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle.
Links for this episode * Zika virus in the Americas (Science) * Co-circulation of dengue, Zika, chik in Brazil (Medicine) * Murine model for Zika virus infection (Am J Trop Med Hyg) * Zika virus susceptibility of A. aegypti and A. albopictus (PLoS NTD) * Infectious Zika virus from saliva (EuroSurveill) * Zika virus spread through saliva? (Braz Oral Res) * Five Zika virus reviews (one, two, three, four, five) * Zika virus and microcephaly, Brazil (MMWR) * Zika virus in urine (EuroSurveill) * Zika virus infection of fetus (NEJM) * Real-time sharing of Zika virus data (JAMA) * Image credit: Richard Kuhn * Letters read on TWiV 383
This episode is sponsored by ASM Agar Art Contest and ASV 2016
Weekly Science Picks
Esper - The Chaos by Gérard Nolst Trenité and HIV pathogenesis courseAlan - Science Kombat
Dickson - Four steps to wiping out a mosquito
Vincent - Public lacks information on Zika virus
Kathy - Zika virus cryo-EM structure video
Listener Picks
Justin - Culture-independent discovery of Archaeal virus
Melinda - Zika virus open research portal and Your body battles series
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove and Kathy Spindler
Guests: Nels Elde and Edward Chuong
Nels and Ed join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses.
Links for this episode * Endogenous retroviruses and regulation of innate immunity (Science) * Placenta is viral (Nature) * An ERV that maintains pluripotency of human embryonic stem cells (TWiV 279) * Letters read on TWiV 382
This episode is sponsored by ASM Agar Art Contest and ASV 2016
Weekly Science Picks
Nels - Don't Get Me Started - Matt GiorgianniAlan - Sun's magnetic field (paper)
Dickson - Most realistic dinosaur terrifies
Vincent - Top secret!
Kathy - Zika virus risk for US 50 cities (paper)
Ed - Watching comb jellies poop
Listener Picks
Asal - Lost paper of Gregor Mendel
Dennis - PhysicsGirl
Jacob - Second (XKCD) and ACI blogger interview
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Carl Zimmer
Carl Zimmer joins the TWiV team to talk about his career in science writing, the real meaning of copy-paste, science publishing, the value of Twitter, preprint servers, his thoughts on science outreach, and much more.
Links for this episode * Carlzimmer.com * All Carl's articles at NYTimes * Carl at Stat * The Loom * Staying afloat in the rising tide of science (Cell) * Parasite Rex * Planet of Viruses * Handful of biologists went rogue (NYTimes)
This episode is sponsored by ASV 2016 and ASM Agar Art Contest
Weekly Science Picks
Carl - Surprising benefit of viral DNAAlan - Global ship traffic
Dickson - Music with 2000 marbles
Vincent - The whiteboard revolution
Kathy - How to interpret UK and American advisors
Rich - Carina Storrs, science writer
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVeroos deliver the weekly Zika Report, then talk about a cryoEM structure of a plant virus that reveals how the RNA genome is packaged in the capsid, and MIMIVIRE, a CRISPR-like defense system in giant eukaryotic viruses.
Links for this episode * First worms, then viruses, now dormant cyber pathogens (Zdziarski blog) * Guillain-Barré with Zika virus in urine (Eurosurveillance) * Zika virus in urine, Brazil (J Clin Virol) * Zika in pregnant women in Rio (NEJM) * Issues with NEJM pregnant women study (Epi-Ramble) * Zika virus and meningoencephalitis (NEJM) * Zika virus and acute myelitis (Lancet) * Person to person transmission of Zika virus (MMWR) * Pyrethroids and mouse microcephaly (one, two) * Zika virus illustrations (Visual Science) * Cowpea mosaic virus at high resolution (Nat Comm) * MIMIVIRE confers resistance to virophage (Nature) * CRISPR in a phage (TWiM 56) * National Academy of Sciences GoFoc meeting * Image credit * Letters read on TWiV 380
This episode is sponsored by ASM Agar Art Contest and Microbe Magazine Podcast
Weekly Science Picks
Alan - Progression of Evolution
Dickson - Toddler dies of meningitis
Vincent - Gardasil ideology, not science
Kathy - The Noun Project
Rich - Physics Girl
Listener Pick Mark - MyRadar app (iOS, Android)
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Scott Tibbetts
Scott Tibbetts joins the TWiVists to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature.
Links for this episode * Noncoding RNA required for establishment of latency (mSphere) 17:20 * Lessons learned from in vivo studies of a viral noncoding RNA (mSphere) 1:05:05 * Zika virus in pregnant women in Rio de Janeiro (NEJM) 1:06:10 * Zika virus infects cortical neural progenitors (Cell Stem Cell) 1:12:00 * Image credit * Letters read on TWiV 379 1:15:10
This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast 4:15, 1:05:25
Weekly Science Picks 1:42:45
Alan - Okeanos Explorer
Dickson - Rome Reborn
Vincent - Twitter Missing Manual
Scott - Best Science Images of 2015
Kathy - Space Travel Posters
Rich - GoISSWatch
Listener Pick Peter - Antibiotics and the Problem of the Broken Market
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guests: Greg Smith and Mark Fuccio
Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus.
Links for this episode * Dynamic ubiquitination drives herpesvirus neuroinvasion (PNAS) * Releasing Zika virus data in real time (Nature) * Zika virus infection and stillbirths (PLoS NTD) * Zika virus infection, imported, Italy (Eurosurveillance) * Letters read on TWiV 378
This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast
Weekly Science Picks
Alan - Science byline counting project
Dickson - Bill Nye on climate change
Vincent - Zdziarski's blog of things (Apple's motion to vacate)
Greg - Atlas, the next generation
Kathy - Sources of Chaco wood
Mark - How Dogs Love Us by Gregory Berns
Listener Pick Bohdan - The real reason for brains
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks review the past week's findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans.
Links for this episode * Larvicide not involved in microcephaly (CBS News) * Obama seeks $1.8b for Zika virus (Guardian) * Zika virus in Puerto Rico (MMWR) * Zika virus in semen (EID) * Zika virus in Indonesia (EID) * Phylogeny of Zika virus (EID) * Zika virus may cause mental disease (NYTimes) * Zika virus from amniotic fluid (Lancet) * Host protein underlies avian influenza host restriction (Nature) * Wendy Barclay on TWiV 177 * Home to roost (Cell) * Image credit * Letters read on TWiV 377
This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast
Weekly Science Picks
Alan - CDC vaccine quiz
Dickson - A telescope so powerful
Vincent - Virology Lectures 2016 (virology blog, iTunes U)
Rich - Ion propulsion (Wiki)
Kathy - Spurious Correlations
Listener Pick Johnye - Magellan telescope and van Egmond photograpy at Kids Should See This
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jeremy Luban
The TWiV team discusses the latest data on Zika virus, including ocular defects in infants with microcephaly, and isolation of the entire viral genome from fetal brain tissue.
Links for this episode * Ocular findings in infants with microcephaly (JAMA and Arq Bras Oft) * Evidence of Zika virus infection in brain and placenta (MMWR) * Zika virus associated with microcephaly (NEJM) * Hard-core sequencing (Science) * Zika virus and microcephaly (virology blog) * Zika virus in the Americas (NEJM) * JEV and WNV transplacental infections * Rubella virus facts (WHO) * Share your Zika virus reagents (virology blog) * No link between anencephaly and Cache Valley Virus (EID) * Image credit * Letters read on TWiV 376
This episode is sponsored by 32nd Clinical Virology Symposium and ASM Microbe 2016
Weekly Science Picks
Alan - PhD Comics on gravitational waves
Dickson - 25 years of Hubble
Vincent - Amazon AWS TOS and Confirming Einstein
Rich - Mosquito mass production
Kathy - TileApp
Jeremy - IL17A and autism and The Perfect Theory by Pedro Ferreira
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Carolyn Coyne, Helen Lazear, and Jeremy Luban
The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more.
Links for this episode * Zika outbreak in Brazil (EID) 13:40 * Zika summary (ProMedMail) 19:30 * Zika and microcephaly (MMWR) 27:30 * Facts about microcephaly (CDC) * Brazil Ministry of Health microcephaly numbers * Zika spread in Americas (MMWR) * Deu Zica 42:30 * Microcephaly in Brazil (Lancet) 46:10 * GM mosquitoes did not start Zika outbreak (Discover) 1:31:30 * Debunking myths around Zika (Mad Virologist) * Sexual transmission vs sexually transmissible (virology blog) 1:22:10 * CDC Zika travel guidance 1:15:45 * CDC on Zika and sex 1:17:10 * Image credit: Esper Kallas, University of Sao Paulo * Letters read on TWiV 375
This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar
Weekly Science Picks 1:50:45
Alan - Jetstream Online School for Weather
Vincent - New virus watercolors from Michele Banks (one, two)
Rich - The Mad Virologist (Facebook, blog)
Kathy - Orcas in Antarctica
Jeremy - Pardis Sabeti on TED
Helen - Science Valentines
Carolyn - Three letter word missing from Zika warnings
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5'-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt's lymphoma.
Links for this episode * Divergent requirements for removing VPg (mBio) * Bond, covalent bond (TWiV 210) * Link between malaria and endemic Burkitt's lymphoma (PLoS Path) * Multifactorial role of malaria in Burkitt's lymphoma (PLoS Path) * Plasmodium infection promotes AID-dependent B cell lymphoma (Cell) * Children's cancer dependent on climatic factors (Nature) * Denis Burkitt (Wikipedia) * Request for PACE trial data (virology blog) * Letters read on TWiV 374
This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar
Weekly Science Picks
Alan - Indoor skydiving
Vincent - Cancer Virus by Crawford, Johannessen, and Rickinson
Rich - Wit
Kathy - The Only Woman in the Room by Eileen Pollack
Dickson - Show everyone your clinical data
Send your virology questions and comments to twiv@microbe.tv
Host: Vincent Racaniello
Guest: Julius S. Youngner
Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine.
Links for this episode * Trypsin for cell cultures (Proc Soc Exp Biol Med) * Interferon induction by nonviral stimuli (J Gen Physiol) * Interferons of different molecular weight (Proc Soc Exp Biol Med) * Poliovirus thermal mutants (J Bacteriol) * Combination of different cells in culture (Science) * Equine influenza vaccine (Eq Vet J) * Younger role in Salk vaccine (interview, amednews) * Cutter Incident (JRSM) * Video of this episode - coming as soon as I can get home!
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency.
Links for this episode * Ebolavirus update (ProMedMail) * Influenza D virus (mBio) * Vincent's influenza C virus paper (J Virol) * Virus-like particles protect wasp eggs (Sci Adv) * CMV protein foils cell defense against latency (Sci Adv) * Image credit: Mark * Letters read on TWiV 372
This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense
Weekly Science Picks
Alan - Go viral
Vincent - 3D virus popsicles (3ders,dangerous popsicles)
Rich - Galileo thermometer
Kathy - Thing Explainer by Randall Munroe
Listener Picks Christiane - Using PowerPoint to shine
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era.
Links for this episode * Second transmissible cancer in Tasmanian Devils (PNAS) * New strains for production of IPV (PLoS Path) * Synchronized switch to bivalent OPV (polioeradication.org) * Virologists, start your poliovirus destruction (virology blog) * Image is a painting by George Kush * Letters read on TWiV 371
This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense
Weekly Science Picks
Alan - Skyfaring by Mark Vanhoenacker
Vincent - Your Cells. Their Research. Your permission?
Rich - NASA UV photos of the sun
Kathy - Aurora bike lights
Dickson - Unfilled vials
Listener Picks
Kevin - John Oliver on nutritional supplements
Jim - Tour of Australian synchrotron
Send your virology questions and comments to twiv@microbe.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
The TWiVomics review ten captivating virology stories from 2015.
Ten virology stories from 2015 * Recoding to make vaccines and study viral functions: TWiV 351: The dengue codeTWiV 362: Gotta catch ’em all and new paper * Defining the virome: TWiV 365: Blood, feuds, and a foodborne disease, TWiV 362: Gotta catch ’em all, TWiV 356: Got viruses?, TWiV 355: Baby’s first virome, TWiV 342: Public epitope #1, TWiV 323: A skid loader full of viromes * Ebola outbreak wanes, vaccines tested, persistence noted: TWiV 361: Zombie viruses on the loose, TWiV 349: One ring to vaccinate them all, TWiV 341: Ebolavirus experiences, TWiV 336: Brought to you by the letters H, N, P, and Eye, TWiV 335: Ebola lite * Spillovers and scares: TWiV 347: Rose rosette and squirrel roulette, TWiV 351: The dengue code, TWiV 364: It’s not SARS 2.0, TWiV 365: Blood, feuds, and a foodborne disease * The “Gain of Function” debate continues: TWiV 321: aTrip and a pause, TWiV 351: The dengue code, TWiV 354: The cat in the HAART, TWiV 363: Eat flu and dyad, and the NSABB’s new draft report * Detailed mechanisms of pathogenesis: TWiV 336: Brought to you by the letters H, N, P, and eye, and TWiV 345: How a vaccine got the nod - plus numerous episodes (324, 328, 329, 330, 339, 343, 349, 353, 369) where we talked about basic research that undergirds these clinically important discoveries. * Dengue vaccines: Trial TWiV 319: Breaking breakbone. Dengvaxia was licensed in December in Mexico, Philippines, and Brazil (12/28); paper we didn’t have time to cover about broadly neutralizing Abs from viremic patients and another paper from same group with X-ray crystal structure of Ab + gpE. * Why do some RNA viruses undergo antigenic variation and others do not? TWiV 340: No shift, measles * TWiV 346: A double helical career * TWiV 345: How a vaccine got the nod * Letters read on TWiV 370
This episode is sponsored by ASM Microbe and ASM Biodefense
Weekly Science Picks
Alan - Scientifics online
Vincent - Giant squid in Tokyo Harbor
Kathy - A Year of Sky
Listener Picks
Daniel - Paper Life
Stephen - How to deal with science denialists
Venkat - Kabisa
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
A swarm of virologists discusses testing of a MERS coronavirus vaccine for camels, and how a neuronal stress pathway reactivates herpes simplex virus.
Links for this episode * MERS coronavirus vaccine for camels (Science) * WHO MERS summary * Neuronal stress pathway and herpes simplex virus reactivation (Cell Host Micr) * Stress flips a chromatin switch (Cell Host Micr) * How herpes simplex virus reactivates (UNC press release) * Histone antibodies database * New antibody portal (UNC press release) * Image credit * Letters read on TWiV 369
This episode is sponsored by Clinical Virology Symposium
Weekly Science Picks
Alan - SpaceX Falcon 9 landing
Vincent - Scientists: Engage the public! and Lego contest winners
Kathy - Google Ngram viewer
Listener Picks
Dennis - Americapox: The missing plague
Mark - WeatherSpark and Quasispecies theory
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
A plaque of virologists explores the biology of Zika virus and recent outbreaks, and the contribution of a filamentous bacteriophage to the development of biofilms.
Links for this episode
- More cowbell (Wikipedia)
- Microcephaly in Brazil (Outbreak News)
- Non-vector borne Zika transmission (EID)
- Zika virus outside Africa (EID)
- Zika virus possible sexual transmission (EID)
- Zika virus in saliva (J Clin Virol)
- Dengue's cousin Zika (Micr Inf)
- Filamentous phage promote biofilm assembly (Cell Host Micr)
- Biofilm history (MSU)
- Pseudomonas phage Pf1
- Image credit
- Letters read on TWiV 368
This episode is sponsored by Clinical Virology Symposium and ASM Microbe
Weekly Science Picks
Alan - Twelve days of norovirus
Vincent - This Week in Evolution
Rich - In the Kingdom of Ice by Hampton Sides
Kathy - Kajanjian lecture on Frederick Novy and Milestones ceremony at UM
Listener Picks
Peter - What if anti-vax, anti-science movement won?
Stephen - Scandalous origin of vaccines
Pritesh - Absurd way of doing business
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Carolyn Coyne and Coyne Drummond
Two Coynes join the TWiV overlords to explain their three-dimensional culture model of polarized intestinal cells for studying enterovirus infection.
Links for this episode * Carolyn and placentas on TWiV 193 * Three-dimensional cell culture model (mSphere) * Bioreactor video (JoVE) * Neurovirologist Richard T. Johnson, 84 (Hopkins and virology blog) * Tardigrade HGT disputed (BioRxiv) * Exaptation of archaeal virus capsid protein from Cas4 (Biol Dir) * Image credit * Letters read on TWiV 367
This episode is sponsored by ASM Microbe
Weekly Science Picks
Kathy - Tardigrade genome sequence (video)
Alan - Antibiotic action nonprofit group
Vincent - Ex Machina and genome editing moratorium
Rich - Launch photography by Ben Cooper
Kathy - HIV life cycle in video (paper)
Dickson - 2015 Nobel Lectures Physiology or Medicine
Carolyn - Metapneumovirus entry
Listener Picks
Tom - Global host-pathogen database
Trudy - Madame Curie by Eve Curie
Send your virology questions and comments to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Carla Giles, Zoe Dyson, Brianna McLean, and Caitlin O'Brien
In Melbourne, Australia, Vincent speaks with four PhD students about their research projects and what it's like to get a doctorate down under.
Video of this episode: view at YouTube
This episode is sponsored by ASM Microbe and ASM Biodefense.
Send your virology questions and comments to twiv@twiv.tv
TWiV is a MicrobeTV Production
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.
Links for this episode * Battle over genome editing (Wired) 10:05 * First description of CRISPR in E. coli (J Bacteriol) 14:00 * Cas genes identified (Mol Micro) 14:20 * CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35 * Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55 * Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50 * Genome engineering using CRISPR/Cas (Science) 18:50 * Cpf1 endonuclease (Cell) 23:10 * Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50 * Summit on gene editing 21:25 * Novel human virus in transfusion recipients (mBio) 27:00 * Origins of hepatitis A virus in small mammals (PNAS) 55:05 * Image credit * Letters read on TWiV 365 7:00, 1:20:35
This episode is sponsored by ASM Microbe, ASM Biodefense, and the 32nd Clinical Virology Symposium. (1:10, 1:18:30)
Weekly Science Picks 1:36:30
Kathy - Tardigrade genome sequence (video)
Alan - XKCD on Gates polio eradication site
Vincent - Lifting the Impenetrable Veil by Charles Calisher
Listener Picks
Judi - Jennifer Doudna's Ted Talk
Ramon - Map of the Sky
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Ralph Baric and Vineet Menachery
Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses to infect human cells and cause disease in mice.
Links for this episode * Zoonotic potential of SARS-like bat viruses (Nature) * SARS-CoV susceptibility loci via collaborative cross (PLoS Genetics) 47:00, 57:25 * Ebright and Wain-Hobson quotes (Nature) 1:17:20 * Misleading press release (UNC) 1:24:45 * Super powerful SARS 2.0 (not!) (Motherboard) * SARS-like bat virus can jump without mutating (not!) (Daily Mail) 1:26:30 * Photo credit * Letters read on TWiV 364 1:47:40
This episode is sponsored by Mt. Sinai Department of Microbiology (2:10), ASM Education (33:25), and the 32nd Clinical Virology Symposium (1:51:30)
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:53:00
Kathy - California Dept of Public Health
Rich - Leafy greens on space station
Vincent - Mechanical keyboards and TWiV on Perfect your podcast
Listener Picks
Jesse - Networking for Nerds by Alaina G. Levine
Russell - Worldmapper
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers reveal influenza virus replication in the ferret mammary gland and spread to a nursing infant, and selection of transmissible influenza viruses in the soft palate.
Links for this episode * Photos of my visit to OHSU (Facebook) 6:30 * Folta departs (Facebook) 9:25 * T-VEC approved for melanoma (FDA) 14:45 * Talimogene laherparepvec (Wikipedia) 15:10 * T-VEC phase III trial (J Clin Oncol) 17:35 * How drugs are named (PopSci) 16:35 * Influenza transmission in mother-child dyad (PLoS Path) 23:10 * Soft palate and influenza transmission (Nature) 41:00 * Blausen 0872 UpperRespiratorySystem" by BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff. "Blausen gallery 2014". Wikiversity Journal of Medicine. DOI:10.15347/wjm/2014.010. ISSN 20018762. - Own work. Licensed under CC BY 3.0 via Commons." target="_blank">Image credit * Letters read on TWiV 363 1:09:30
This episode is sponsored by Mt. Sinai Department of Microbiology, ASM Education, and ASM Biodefense and Emerging Diseases Conference
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:29:00
Kathy - Insect gears
Alan - Bye, Bye, Ebola
Rich - Hedy Lamarr
Vincent - Should we resurrect extinct species?
Listener Picks
Jennie - Bye, Bye, Ebola
Peter - Epidemics on edX
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
With their usual verve, the virus virtuosos illuminate a new method to identify all the viral nucleic acids in a sample, and regulation of viral gene expression by codon usage.
Links for this episode * Virome capture sequencing (mBio) 15:40 * Codon usage regulates viral gene expression (PNAS) 40:00 * Harold S. Ginsberg (Wikipedia) 7:15 * Letters read on TWiV 362 6:50, 1:03:20
This episode is sponsored by ASM Education: ASM MOOC 5:45
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:39:20
Kathy - Adam Savage, Andy Weir and Chris Hadfield talk about The Martian
Alan - Project Apollo photo archive - and video
Rich - Watch A Bowling Ball And Feather Falling In A Vacuum
Dickson - California drought
Vincent - Does AAAS care about Ebola anymore?
Listener Picks
Anonymous - Lives saved by vaccination
Paul - Science articles: A guide
Judi - How a virus invades your body
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiVsters discuss Frederick Novy's return from retirement to recover a lost rat virus, and evidence for persistence of Ebolavirus in semen.
Links for this episode * Frederick Novy and the rat virus (Ann Int Med) 18:20 * The rat virus (J Inf Dis) 22:55 * Recovery of the rat virus (J Inf Dis) 35:20 * Ebola sitrep 42:25 * Meningitis in Glaswegian Ebolavirus nurse (ProMedMail, Medscape) 45:50 * Sexual transmission of Ebolavirus (NEJM) 50:25 * Ebolavirus RNA persistence in semen (NEJM) 1:04:25 * Airplane banner falls into Hudson River (jpg) * Image credit * Letters read on TWiV 361 7:25, 1:13:25
This episode is sponsored by ASM Education: ASM MOOC 3:50
Weekly Science Picks 1:27:05
Alan - Sticky
Rich - Arthur C. Clarke predicts the Internet (so did Vannevar Bush)
Dickson - Nikon Small World Photomicrography winners
Vincent - Pat Schloss on microbiome initiative
Listener Picks Awkward Skeptic - 16 year old wins Google prize for detecting Ebolavirus
Timestamps by Jennifer. Thanks!
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Michael Imperiale, Adam Lauring, and Akira Ohno
Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site.
Links for this episode
- World Polio Day 3:20
- Mole Day 5:25
- The rat virus (J Inf Dis) 20:00
- Polyomavirus miRNAs (Curr Op Virol) 39:30
- Costs of GOF pause (mBio) 45:00
- Lethal mutagenesis of influenza virus (J Virol) 1:03:35
- Mutational robustness in RNA virus evolution (Nat Rev Micro) 52:00
- Membrane binding of gag (mBio) 1:12:55
- Cell proteins in retrovirus particles (J Virol) 1:23:15
- Michael's twitter
- Adam's twitter
- Video of this episode - view below or at YouTube
Weekly Science Picks 1:27:30
Kathy - Ada Lovelace and Charles Babbage Lego #1 and #2 and Ada Lovelace Day
Vincent - MiSciWriters
Listener Picks
Junio - XKCD marks the spot
Kari - Spoonflower
Send your virology questions and comments to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Blossom Damania
Vincent speaks with Blossom about her laboratory's research on Kaposi's sarcoma-associated herpesvirus, including how it transforms cells, the switch between lytic and latent replication, and its interaction with the innate immune system of the host.
Links for this episode * Damania Laboratory * Modulation of cGAS-STING by KSHV (PNAS) * KSHV vIRF1 interacts with ISG15 pathway member (J Virol) * KSHV NLR homolog inhibits inflammasome (Science) * KSHV inhibition of PI3K and mTOR (Blood) * KSHV confers survival advantage to endothelial cells (Cancer Res) * UNC Global Oncology Program * Blossom on Twitter * Video of this episode - view at YouTube
Send your virology questions and comments to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Ileana Cristea
Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host.
Links for this episode * Cristea Laboratory * Ileana's work previously on TWiV 269 * Blowing off steam (Cell Host Micr) * Nuclear viral DNA sensors (J Biol Chem) * mSystems * Video of this episode - view at YouTube (coming soon!)
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jens Kuhn
Jens joins the TWiVomics to discuss the strengths and weaknesses of viral taxonomy, including its history and evolution, how viruses are ordered, and why T. rex was classified without having a living isolate.
Links for this episode * Jens' previous TWiV (283) 5:15 * International Committee on the Taxonomy of Viruses (ICTV) 27:50 * ICTV 9th Report 32:55 * Classifying viruses by capsid architecture (Curr Opin Virol) 1:43:00 * Image credit * Letters read on TWiV 357 10:55, 1:55:40
Timestamps by Jennifer. Thanks!
Weekly Science Picks 56:30, 2:07:15
Alan - The Jefferson Grid
Rich - Summer of Science
Kathy - Bill Nye dances The Click
Dickson - The Martian
Jens - How I Killed Pluto, Life in Our Phage World, Why the Seahorse Tail is Square
Vincent - Does the public trust science? (videos, summaries)
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Stephanie Neal
Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine.
Links for this episode * Invitrogen Science Hero Awards 15:05 * Gut DNA viromes of twins with severe malnutrition (PNAS) 34:30 * Random forests 48:00 * Wasps engineer caterpillars (PLoS Genetics) 50:20 * Chemokine-adjuvanted SIV DNA vaccine (Mucos Immunol) 1:02:20 * Guide to chemokines (pdf) * Role for CCR10 in IgA secreting cell accumulation (J Immunol) * CCL28 controls IgA plasma cell accumulation (J Exp Med) * In vivo electroporation 1:07:25, 1:09:50 * Kathy's groan (jpg) * Image credit * Letters read on TWiV 356 14:55
Weekly Science Picks 1:18:35, 1:45:30
Alan - Plates from Hooke's Micrographia
Rich - The Wright Brothers by David McCullough
Kathy - Spore evaporation-driven engines (video and article)
Dickson - Color variations of Pluto and Lunar total eclipse
Stephanie - The science of moldy cheese by Carl Zimmer
Vincent - But Why?
Listener Pick of the Week Reed - The Bench Warmers Podcast
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team considers the effect of a Leishmaniavirus on the efficacy of drug treatment, and the human fecal virome and microbiome in twins during early infancy.
Links for this episode * Announcing mSphere 5:50 * Leishmania virus influences drug outcome (paper 1, paper 2) 25:15 * Human gut virome and microbiome in infants (Nat Med) 46:00 * Multiple displacement amplification (Wiki) 46:00 * Virome of adult twins (Nature) 49:15 * Illumination by Kevin Folta 1:31:00 * Folta story at RetractionWatch 1:41:40 * Image credit * Letters read on TWiV 355 9:40, 1:20:30
This episode is sponsored by ASMGAP 5:00
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:42:20
Alan - Vexed Muddler store
Rich - Ivanpah Solar Power Facility
Kathy - The real Kermit
Dickson - Animal Portraits
Vincent - Adventures of the Regatjes, Vaccines by Susan Nasif
Listener Pick of the Week Jacob - Great Wall of China keeps rabbits out
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus.
Links for this episode * Non-viral proteins in vaccinia virus particles (Arch Virol) 8:15 * Thing a week (Jonathan Coulton, downloads) 23:20 * Immortal Life pornographic? Not! (HuffPost) 25:25 * Mollivirus sibericum (PNAS) 27:00 * Don't worry about Frankenvirus (WashPost) 27:10 * We need flu GOF research (article, Wisc State J, Science) 40:35 * Isolation of FIV (Science) 50:20 * FIV at Cornell Vet 1:06:25 * FIV latency (Retrovirol) 1:08:00 * FIV-receptor interactions (Curr Op Virol) 1:08:45 * Clin aspects FIV infection (Viruses) * FIV antivirals (Viruses) 1:10:05 * How to treat FIV 1:10:45 * Bud's FIV therapy 1;10;50 * FIV vectors (CSH Prot) 1:13:50 * Lion FIV (Proc Biol Sci) * FIV in cat species (J Virol) 1;01;45 * ACIP HVP vaccine recommendations (MMWR) 1:28:45 * HPV and cancer (CDC) 1:33:45 * Cervical cancer screening (pdf, CDC) * Letters read on TWiV 354 7:45, 1:17:10
This episode is sponsored by ASMGAP
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:40:40
Alan - Experience Curiosity
Rich - Primrose School
Kathy - Egg drop solutions
Dickson - Dragonflies by Pieter van Dokkum
Vincent - NASA guide to air-filtering houseplants
Listener Pick of the Week Amir - Publons (Nature article)
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.
Links for this episode * 28 years of poliovirus shedding (PLoS Path) 36:50 * NOT a rare poliovirus (Wash Post) 44:35 * Ukraine polio outbreak (ProMedMail) 41:00 * Virus particle transfer of cGAMP (Science one, two) 47:50 * cGAS on TWiV 222 47:05 * Image credit * Letters read on TWiV 353 6:30, 1:10:25
This episode is sponsored by ASMGAP 3:10
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:27:50
Alan - Miniature calendar
Kathy - Dr. Brainlove (prologue, v. 2.0, IndieGoGo)
Dickson - The Ph.D. Movie
Vincent - Ghostery
Listener Pick of the Week
Ramon - Children die
Chris - ASMLive at ICAAC/ICC
Send your virology questions and comments to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Michele Banks
Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art.
Links for this episode * Michele Banks on Twitter * Artologica * Michele's blog * The Finch and the Pea * Joseph Cornell * Not Exactly Rocket Science (Ed Yong) * Tree of Life (Jonathan Eisen) * Home Microbiome Study * Kitten Microbiome Project * Science Online * The Vexed Muddler * Luke Jerram * A Daily Dish (Klari Reis) * Neuroscience art (Greg Dunn) * Ai Weiwei * Video of this episode - coming soon * Video of Michele working in her studio - view at YouTube
Send your virology questions and comments to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.
Links for this episode * Paula Pitha-Rowe (Balt Sun) * Novel poxvirus (CID) * H1N1 and gain-of-function debate (mBio) * Recoding dengue virus genome (PNAS) * Attenuation by dinucleotide frequency change (PNAS) * Codon pair and dinucleotide bias not distinguished (PNAS) * Codon pair deoptimization artefact of CG/UA change (eLife) * Can engineering subdue viral vaccine reversion? (Virus Evol) * Attenuation by a thousand cuts (NEJM) * Image credit * Letters read on TWiV 351
Weekly Science Picks
Alan - Genetic roulette Rich - The Huntington
Kathy - Simulated vomiting machine (video)
Dickson - Last Cassini Saturn flyby
Vincent - Decaying Still Life (YouTube)
Listener Pick of the Week Ken - Cave meterology (Times, Nature)
Send your virology questions and comments to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Katherine A. High
Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders.
This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology.
Links for this episode * Katherine A. High, MD * AAV gene therapy for congenital blindness (Sci Trans Med) * Gene therapy for hemophilia (Hematol) * AAV capsid decoys (Sci Trans Med) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea.
Links for this episode * Social media specialist position at ASM * WHO dismisses Catholic church on vaccine safety * U of T Dean resigns over anti-vaccine course (Tor Star) * Vaccine Adverse Event Reporting System (VAERS) * Countering anti-vaccination attitudes (PNAS) * Designer ribosome (Nature) * rVSV-EBOV preliminary report (NEJM) * rVSV-EBOV phase III interim report (pdf, Lancet) * World on verge of Ebolavirus vaccine (WHO) * Ebolavirus vaccine in Africa (virology blog) * Letters read on TWiV 349 11:55
This episode is sponsored by ASM GAP
Weekly Science Picks
Alan - Above and Beyond Rich - DSCOVR (Dark moon side crossing Earth)
Vincent - Stuxnet virus (Wired, YouTube)
Listener Pick of the Week Konrad - Stated Clearly
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses.
Links for this episode * Virology tenure-track position at NCI (pdf) * ASM Agar Art Contest * Nigeria on brink of polio eradication (Nature) * Dengue in Africa (Tyler Sharp) * Permissive vaccines and virulence (PLoS Biol) * Marek's disease vaccines and virulence (Ed Yong) * Image credit * Letters read on TWiV 348
This episode is sponsored by ASM GAP
Weekly Science Picks
Rich - Swan-Ganz catheter (Wiki, video)
Vincent - Mobile DNA III
Listener Pick of the Week Kevin - Synthetic prions
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus.
Links for this episode * Virology tenure-track position at NIH (pdf) 7:00 * Voinnet investigation is a Swiss Federal secret (twitter) 12:25 * Rose rosette disease in Ft. Worth (Star Telegram) 29:35 * Rose rosette virus discovered (J Gen Virol) 34:25 * Emeravirus (ViralZone) 33:55 * Eriophyid mites (MI Botanical Garden) 32:40 * Mite vector of rose rosette disease (U Florida) 34:55 * Image credit * Squirrel bornavirus associated with human encephalitis (NEJM) 38:40 * Poll: How do you consume podcasts? 1:21:40 * Letters read on TWiV 347 8:10, 59:40
This episode is sponsored by ASM GAP and ICAAC/ICC
Time stamps by Jennifer. Thanks!
Weekly Science Picks 1:17:05
Alan - National Immunization Awareness Month (Twitter campaign)
Rich - Rosie Revere, Engineer by Andrea Beaty
Vincent - iPhone owns podcasts (9to5Mac)
Listener Pick of the Week
Sandra - World Zoonoses Day graphic
Peter - Mammal-carnivorous plant mutualism (bat and shrew)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guest: Joan Steitz
This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation.
Links for this episode * ASV annual meeting, Western University * Steitz Laboratory at Yale University * Steitz Laboratory on Twitter * Panoramic photo of ASV TWiV by Matt Evans * Photos of ASV2015 (Facebook) * Video of this episode - view at YouTube
Weekly Science Picks
Kathy - Charity Hall Rich - Ribosome binding sites of phage R17 mRNA
Vincent - Pluto flyby
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVonauts review how the weather affects West Nile virus disease in the US, benefit of B cell depletion for ME/CFS patients, and an autoimmune reaction induced by influenza virus vaccine that leads to narcolepsy.
Links for this episode * Virology faculty position, University of Toledo * Weather and West Nile virus disease (AJTMH) * B cell depletion benefits ME/CFS patients (PLoS One) * Antibodies to influenza nucleoprotein cause narcolepsy (Science Transl Med) * Letters read on TWiV 345
This episode is sponsored by ASM GAP - turn your science into a company
Weekly Science Picks
Dickson - Algal DMS releasing enzyme Alan - Science of beer aging
Kathy - The Art of Science winners
Vincent - The future of Lego plastics
Listener Pick of the Week
Eric - Economics in One Lesson by Henry Hazzilit
Stephen - The Martian by Andy Weir (audiobook)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Ruth Jarrett, Glen Nemerow, and Esther Schnettler
At the Glasgow Science Festival microTALKS, Vincent speaks with Ruth, Glen, and Esther about their research on viruses and Hodgkin lymphoma, adenovirus structure and entry into cells, and interactions between arthropod borne viruses and their hosts.
Links for this episode * Glasgow Science Festival microTALKS * Hodgkin lymphoma (Histopath) * HHV-6 and Hodgkin lymphoma (PLoS One) * Adenovirus entry (PLoS Path) * Adenovirus membrane penetration (Virology) * Mosquito pathways that limit CHIK replication (PLoS Negl Trop Dis) * Tick antiviral RNAi (Nucl Acids Res) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVerinoes discuss the potential for prion spread by plants, global circulation patterns of influenza virus, and the roles of Argonautes and a viral protein in RNA silencing in plants.
Links for this episode * Prions in plants (Cell Rep) 11:35 * Global influenza virus circulation (Nature) 20:40 * Rough patch for plant RNA silencing (Lab Times) 29:50 * Role of Argonaute proteins in plant viral defense (PLoS Path) 32:15 * Rub-inoculation (YouTube) 42:45 * Image credit * Letters read on TWiV 343 4:00, 1:11:45
Timestamps by Jennifer. Thank you!
Weekly Science Picks 1:41:45
Dickson - Global rainfall and snowfall map and A Week in the Life of Rain Alan - Automated patch clamp
Kathy - More Women in Science mini Legos
Rich - The Martian trailer
Vincent - It's a bug's life
Listener Pick of the Week May - p53 by Sue Armstrong
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVniks discuss the structure of a virus that reproduces in an extreme environment, long-term consequences of Ebolavirus infection, and VirScan, a method to identify the different virus infections you have had in your lifetime.
Links for this episode * Virus with A-form DNA (Science) * Viruses in the extreme (virology blog) * Sequelae of Ebolavirus infection (Lancet Inf Dis) * Long term Ebolavirus effects (virology blog) * Take the chili ME challenge * Serological profiling of human viral infections (Science) * Your viral past (virology blog) * Letters read on TWiV 342
Timestamps by Jennifer. Thank you!
Weekly Science Picks
Dickson - Incredible photos Alan - Alone in a room full of science writers
Kathy - Calico cats and Siamese cats
Rich - Missing link in evolution
Vincent - Podcasts saving NPR and Podcasting blossoms
Listener Pick of the Week
Jenny - What Bill Gates is afraid of
Neva - The Kardashian Index
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Adam Kucharski, Gillian Slack, and Emma Thomson
Vincent returns to the University of Glasgow MRC-Center for Virus Research and speaks with Emma, Gillian, and Adam about their ebolavirus experiences: caring for an infected patient, working in an Ebola treatment center in Sierra Leone, and making epidemiological predictions about the outbreak in west Africa.
Links for this episode * Tribute to Richard Elliott * Donate to mesothelioma research for Richard Elliott * CVR science blog * Photos of our visit * Ceilidh goes viral! * Video of this episode - view below or at YouTube
Timestamps by Jennifer. Thank you!
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation.
Links for this episode * Richard Elliott on TWiV 177 * MERS-CoV outbreak, South Korea (ProMedMail) * MERS-CoV serosurvey (Lancet Inf Dis) * Biolabs in your backyard (USA Today) * Constraints on measles virus antigenic variation (Cell Rep) * Selection bias and bombers (John D. Cook) * Virology (journal) * Image credit: Cameron Moll * Letters read on TWiV 340
Weekly Science Picks
Dickson - Singapore Flower Dome and Cloud Forest Alan - Rescuing biomedical research
Kathy - The value of basic research
Rich - Virology 60th Anniversary Issue
Vincent - Careers in virology: Science writing and journalism
Listener Pick of the Week
Pritesh - How T cells kill cancer cells
Ramon - The power of herd immunity
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Tre TWiV amici present three snippets and a side of sashimi: how herpesvirus inhibits host cell gene expression by disrupting transcription termination.
Links for this episode * Searching for Steamer in the oceans * Lassa fever death in NJ (CDC and NYTimes) * Transgenic mouse model for MERS-CoV (J Virol) * First West Nile virus disease case in Texas * Herpesvirus disrupts host transcription termination (Nat Comm) * Sashimi plots * Broad benefits of measles virus immunization (TWiM #104) * Avian influenza outbreak (NPR) * The virome in health and disease (Immunity) * Image credit * Letters read on TWiV 339
Weekly Science Picks
Alan - Fooling millions into thinking chocolate helps weight loss
Kathy - Approaching Pluto
Vincent - ASM Agar art contest
Listener Pick of the Week
Daniel - FB pages you need to stop sharing from (one and two)
Ken - Bird box science (canceled)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Kathy Spindler
Guest: Laura Newcomb
Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection.
Links for this episode * Neuron-specific mosquito antiviral mechanism (PLoS Path) * Letters read on TWiV 338 * Photos of our visit * Video of this episode - view at YouTube
Weekly Science Picks
Laura - NP siRNA inhibits different influenza viruses (Antiviral Res)
Kathy - Time-lapse mining
Vincent - Does the public trust science?
Listener Pick of the Week
Paul - Degree-Off XKCD
Peter - Ebola containment, Hans Rosling, eLife podcast, Naked Scientists
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Michael Metzger and Steve Goff
Vincent meets up with Michael and Steve to discuss their finding of a transmissible tumor in soft shell clams associated with a retrovirus-like element in the clam genome.
Links for this episode * Hemocytic leukemia in soft shell clam (Sci Total Environ) * Activation of Steamer in neoplastic hemocytes (PNAS) * Transmission of clonal cancer cells in clams (Cell) * Steve Goff on TWiV #76 * Image credit
Timestamps by Jennifer. Thank you!
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids.
This episode is sponsored by @ASM Conferences and ASM Microbe
Links for this episode * Life threatening influenza and IRF7 deficiency (Science) * Whole exome sequencing (Wikipedia) * Herpes encephalitis in children with Trif deficiency (TWiV 175) * Avian influenza in the US (USDA, ProMedMail, CDC) * Ebola eye (NEJM, NYTimes) * Viral persistence (Virology lectures, pdf) * Uveitis (National Eye Institute) * Image credit * Stability of Ebolavirus on surfaces (EID) * Ignorance with Stuart Firestein (TWiV Special) * Letters read on TWiV
Timestamps by Jennifer. Thank you!
Weekly Science Picks
Alan - Winogradsky time-lapse
Rich - Missing link in evolution of complex cells
Kathy - Grantome
Dickson - National Geographic Landscape Photo of the Day
Vincent - PyMol and Chimera
Listener Pick of the Week Mauricio - Vax!
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants.
This episode is sponsored by ASM Microbe and ICAAC/ICC
Links for this episode * Possible sexual transmission of Ebolavirus (MMWR) * Ebolavirus whole-virus vaccine protects primates (Science) * Biologically contained Ebolaviruses (PNAS) * Ebolavirus is evolving but not changing (Virology) * Ebolavirus not undergoing rapid evolution (Science) * Letters read on TWiV 335
Timestamps by Jennifer. Thank you!
Weekly Science Picks
Alan - Pinboard
Rich - Academic medicine investment in medical research
Kathy - Tissue paper stop motion animation
Dickson - Do peer review panels select best science proposals?
Vincent - MMR and autism: Still no association
Listener Pick of the Week
Ramon - Autism by MMR vaccine status
Mehul - Ebolavirus disease course
Justin - Molecular Biology of Bacterial Viruses by Gunther S. Stent
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget.
This episode is sponsored by SciMed Solutions and ASM Education.
Links for this episode * Pinot noir and viruses (Wine Spectator) 35:00 * Endogenous florendoviruses (Nat Commun) 35:30 * Sex and Ebolavirus transmission (WHO, CDC, NYTimes) 54:10 * Ebolavirus waiting (NYTimes) 57:35 * Canine influenza outbreak (ProMed, NorthStarVets) 1:01:10 * Dr. Oz under fire (NYTimes) 1:06:20 * TV doctors (Brit Med J) 1:09:50 * Double the NIH budget (NYTimes) 1:11:45 * Image credit: Grapes and Caulimovirus * Letters read on TWiV 334 6:10
Timestamps by Jennifer. Thank you!
Weekly Science Picks 1:17:05
Alan - NIH RFI: How do we fix this mess?
Rich - Editing embryos (PopSci, Prot Cell)
Kathy - Creative class presentations (one, two, three, four)
Dickson - The most tornadoes
Vincent - Apollo 13, 45 years later (Ars, IEEE, Farewell)
Listener Pick of the Week Johnye - Rudolf and Leopold Blaschka
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Host: Vincent Racaniello
Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers
Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program.
Links for this episode * MTGR1 and intestinal secretory lineage allocation (Faseb J) * Coronaviruses induce macropinocytosis (mBio) * PD-1 and respiratory virus reinfection (J Immunol) * Vanderbilt MSTP on Facebook * Video of this episode: view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Seth Bordenstein, James Crowe, and Mark Denison
Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses.
Links for this episode * SARS-CoV error correction (PLoS Path) 19:00 * Marburg virus neutralization by a human antibody (Cell one and two) 56:35 * Phage WO, Wolbachia and Drosophila (Peer J) 1:02:00 * Seth's blog Symbionticism 1:31:30 * Seth on Twitter * Video of this episode: view at YouTube
Timestamps by Jennifer. Thank you!
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease.
This episode is sponsored by SciMed Solutions and ASM Education.
Links for this episode * Clusters of AFP associated with enterovirus D68 (Lancet) 31:35 * Novel outbreak enterovirus D68 strain (Lancet Inf Dis) 53:00 * Enterovirus D68 in Norway (Euro Surveill) 1:12:00 * Unknown enemy (Nature) 1:10:40 * Enterovirus D68 on TWiV 302 * Letters read on TWiV 331 8:00, 1:23:50
Timestamps by Jennifer. Thank you!
Weekly Science Picks 1:53:50
Alan - OU0POLIO ham radio special event station (on air reports)
Rich - Crane building itself (YouTube)
Kathy - Vaccine heroes LEGO project
Dickson - Life at the limits
Vincent - Emperor of all Maladies film and Conference gender balance
Listener Pick of the Week Jake - Designing useful microbes
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes.
Links for this episode * NYAS Afterschool STEM Mentoring Program * Concerns about editing the human germline (Science, Nature) * Engineering the perfect baby (MIT Tech Rev) * RNA recognition by HCV polymerase (Science) * Kickstarting an RNA polymerase (Science) * A protein platform for priming (virology blog) * Apoenzyme and holoenzyme (Wikibooks) * Ebolavirus will not become a respiratory pathogen (virology blog) * Burkholderia pseudomallei (CDC) * Letters read on TWiV 330
Timestamps by Jennifer. Thank you!
Weekly Science Picks
Alan - X-Flare 2.1 captured
Rich - Volvo ocean race drops research buoys (YouTube)
Kathy - Nature double-blind peer review
Dickson - Largest cave in the world
Vincent - New program for early-career scientists
Listener Pick of the Week
Michael - Space Engine and Kerbal Space Program
Varun CN - Incognito by David Eagleman
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection.
Links for this episode * Immune signatures in ME/CFS (Science Adv) 11:15 * Systemic exertion intolerance disease (Lancet) 19:50 * Cell nuclease controls anti-viral responses (Cell Host Micr) 25:10 * Poxvirus decapping enzymes prevent innate responses (Cell Host Micr) 1:15:40 * Caps off to poxviruses (Cell Host Micr) * Drummer Mohr (YouTube) 1:24:05 * Bornavirus in squirrel breeders (ProMedMail) 1:28:45 * Principles of Microbial Diversity 5:30 * Journal of Microbiology & Biology Education 1:24:25 * Cross-stitch by Anne Marie 1:34:40 * Letters read on TWiV 329 1:25:00
Timestamps by Jennifer. Thank you!
Weekly Science Picks 1:35:10
Alan - NASA Solar Dynamics Observatory video
Rich - Mutagenic chain reaction (Video: Genome editing with CRISPR)
Kathy - Science Ambassadors Program
Dickson - Street Art
Vincent - End Polio Now
Listener Pick of the Week
Ross - Three PhD Comics on Nature vs Science (one, two, three)
Ricardo - Demographic Party Trick
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.
Links for this episode * Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path) * Prp8 protein of the spliceosome (RNA) * Nuclear entry of poliovirus RdRp (Virol) * RNA processing (TWiV 216) * Measles in USA (CDC) * Principles of Microbial Diversity * Journal of Microbiology & Biology Education * Letters read on TWiV 328
Weekly Science Picks
Alan - Positively Negative (PLoS One)
Rich - ISS assembly (YouTube)
Kathy - Ancient trees
Dickson - Carolyn Porco
Vincent - Tony Fauci on Ebola outbreak (YouTube)
Listener Pick of the Week
David - Shot by Shot
Judi - The Power of Herd Immunity
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas.
Links for this episode * Traces of ATCV-1 associated with laboratory contamination (PNAS) * ATCV-1 findings not explained by contamination (PNAS) * Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS) * INNO-LIA * Principles of Microbial Diversity * Image credit: John * Letters read on TWiV 327
Weekly Science Picks
Alan - California bill to eliminate personal vaccine exemptions
Rich - Kepler observatory (Kepler-186f)
Kathy - USGS disease map
Dickson - Philosphy of Microbiology by Maureen O'Malley
Vincent - Nautilus
Listener Pick of the Week
Ken - Life in our phage world (online, book party); All about that base
Neal - Gilles van Cutsem at CROI
Ricardo - Flow hive
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles.
Links for this episode * Dif-tor heh smusma (NY Times) * Immunization preterm premature infants (Thanks, Johnye!) * HIV and SHIV protection conferred by eCD4-Ig (Nature) * Tyrosine sulfation (Wikipedia) * GBV-C and Ebolavirus infection (J Virol) * Letters read on TWiV 326
Weekly Science Picks
Alan - Toms River by Dan Fagin
Rich - Spin by Robert Charles
Vincent - FCC votes for net neutrality (ArsTechnica)
Listener Pick of the Week
Neal - Why doesn't everyone get the flu vaccine?
Fernando - Zombie Jonas Salk hunts idiots
Neva - Physicists in biology
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Rollie Clem and Lorena Passarelli
Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses.
Links for this episode * Apoptosis inhibition in A. aegypti (Apop) * Initiator caspase in armyworm (Insect Bioc Mol Biol) * Manipulating apoptosis in A. aegypti (J Virol) * Viral inhibitors of apoptosis (Sem Cell Dev Biol) * Baculoviruses: Sophisticated pathogens (PLoS Path) * Baculovirus morphogenesis (Virol) * Barriers to baculovirus success (Virol) * Baculovirus endonuclease (J Virol) * Baculovirus DNA damage response (J Virol) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Lee Feinman
Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus.
Links for this episode * Spin by Robert Charles Wilson * Immunization of preterm infants (Dev Period Med) * miR-122 alters HCV translation-replication balance (Cell Host Micr) * Holding a miR to HCV (TWiV 180) * Treating hepatitis C by blocking miR-122 (virology blog) * Click chemistry (Wikipedia) * Image credit * Ebolavirus sitrep (WHO) * Letters read on TWiV 324
Weekly Science Picks
Lee - Furthering America's Research and Upgoer five and six Alan - Best snow shovel
Rich - Ripple tank
Kathy - Fractals
Dickson - World Press Photo Contest 2015
Vincent - What to do about antivax politicians and physicians
Listener Pick of the Week
Patricia - Future of Bioscience Graduate & Postdoc training
Paul - This is my son Griffin, and he may have measles
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The family TWiVidae discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis.
Links for this episode * Enteric virome changes in inflammatory bowel disease (Cell) * Gov. Christie stumbles on vaccination (NY Times) * Anti-vax psychology (NPR) * Vaccine skeptic changes her mind (NPR) * Ebolavirus sitrep (WHO) * Letters read on TWiV 323
Weekly Science Picks
Alan - Sitesucker
Rich - Snake picked wrong dinner
Dickson - Sapporo Snow Festival
Vincent - Mapping NYC subway DNA
Listener Pick of the Week
Gretchen - Scientific way to cut a cake
Leslie - Principles of Virology, Second Edition
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more.
Links for this episode * Bourbon virus (NY Times) * Thogotovirus (ViralZone) * Drug induced apoptosis and HIV infection (PLoS One) * Mumps cases and outbreaks (CDC) * Opossums as pets? (doc) * Cat found * Letters read on TWiV 322
Weekly Science Picks
Alan - Boom by Tony Horowitz
Kathy - Octopus supermom
Dickson - Macrophotography
Vincent - Virology lectures 2015 (virology blog and YouTube)
Listener Pick of the Week
Paul - Illsville: Fight the Disease
Ramon - Vaccinate! Do it for the testicles
Sandra - Who can you trust?
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Paul Duprex
Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.
Links for this episode * Wain-Hobson objects (one, two, three, four) * Influenza H7N1 transmission experiments (J Virol) * Epistemological perspective on aTRIP experiments (mBio) * Limited scientific value and risk (mBio) * Reply to limited scientific value (mBio) * Risks and benefits of aTRIP experiments (mBio) * Apocalypse as rhetorical device in aTRIP debate (mBio) * Moratorium on aTRIP experiments * Moratorium on aTRIP research (mBio) * Risks of influenza virus transmission experiments (mBio) * Reply to risks of influenza virus transmission experiments (mBio) * Vagueness of moratorium on aTRIP experiments (mBio) * Role of aTRIP experiments in vaccine recommendation (mBio) * Use of aTRIP data for surveillance and preparedness (mBio) * aTRIP towards lexiconic precision (mBio) * October 2014 NSABB meeting on aTRIP * NAS aTRIP meeting (YouTube) * MERS-CoV aTRIP experiments exempted (ScienceInsider) * aTRIP: time for a debate (Nat Rev Micro) * Effect of aTRIP moratorium on trainee plans (mBio) * Make the moratorium permanent (Sci Am) * Image credirt: John Morris * Letters read on TWiV 321
Weekly Science Picks
Alan - In a Sunburned Country by Bill Bryson
Paul - Saving the lives of our dogs (blog post)
Kathy - New all-female Lego set
Dickson - Female storm-chaser
Vincent - Despommier Photo Art
Listener Pick of the Week
Jacob - Exaggeration in news and press releases (BMJ)
Peter - Quartet game (photos: one, two, three, four, five)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guest: John Coffin
Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries.
Links for this episode * John Coffin (Wikipedia) * Specific HIV integration sites (Science) * Novel retrovirus in modern birds (J Virol) * Recombinant origin of XMRV (Science) * Cranberry harvest (jpg)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.
Links for this episode * Efficacy of dengue vaccine (NEJM) * Preventing dengue (NEJM) * Dengue viruses (Scitable) * Intention to treat (Wikipedia) * Image credit: Jean-Yves Sgro * Letters read on TWiV 319
Weekly Science Picks
Alan - The Toaster Project by Thomas Thwaites
Rich - SpaceX reusable rocket (SpaceX)
Kathy - Antarctica: A Year on Ice
Dickson - NHL Mumps outbreak and Hubble Andromeda image
Vincent - We the Microbiologist
Listener Pick of the Week
Neva - Mosquito earrings
Basel - Flu vaccine selection meeting
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.
Ten virology stories of 2014 * Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283) * Directional uncoating of rhinovirus RNA (TWiV 267) * Pandemic pathogen controversy (TWiV 287) * Viral evolution (TWiV 275) * Borna virus inhibition by endogenous DNA (TWiV 303) * MERS-CoV in dromedary camels (TWiV special, TWiV 287) * Oncolytic measles virus (TWiV 298) * Amazing norovirus findings (TWiV 312 and 313) * Toxin delivery to aphids (TWiV 272) * The Salk Legacy (TWiV 281)
Links for this episode * Bat-filled tree (Science) * Possible Ebola virus lab exposure (CIDRAP) * Mishandling of Ebola virus sample (NY Times) * Where could Ebola virus strike next? (NPR) * New Legos of female scientists * Photo and cookie by Kathy Spindler * Letters read on TWiV 318
Weekly Science Picks
Alan - Mystery photos from CERN
Rich - Adam E. Cohen: Bringing bioelectricity to light
Kathy - Wired's top microbe stories of 2014
Dickson - Mouse joke
Vincent - The Science of Epidemics (Time Inc Special)
Listener Pick of the Week
Neva - Sir Bacteriophage
Sagi - An unboring polio documentary
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa
On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.
Video of this episode: view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis.
Links for this episode
- IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS)
- Th17 cells involved in influenza mediated gut injury (J Exp Med)
- Helper T cells
- 2014-15 flu season (CDC)
- Key facts about flu & flu vaccine (CDC)
- Does the flu vaccine work? (Turbid plaque)
- Effectiveness of flu vaccine (virology blog)
- Image credit
- Letters read on TWiV 316
Weekly Science Picks
Alan - It came from the pond
Rich - Wanderers
Kathy - The Sense of Style by Steven Pinker
Vincent - Life in Our Phage World
Listener Pick of the Week Fernando - Reality based?
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.
Links for this episode * National Influenza Immunization Week (CDC) * Densovirus associated with sea star wasting disease (PNAS) * A virus that melts sea stars (virology blog) * Chlorovirus in human oropharynx (PNAS) * Algal virus in humans (virology blog) * Image credit * Letters read on TWiV 315
Weekly Science Picks
Alan - ReelLife Science 2014 Winners
Rich - The Martian by Andy Weir
Kathy - Dance Your Ph.D. Winner
Vincent - Time Person of the Year 2014 - The Ebola Fighters
Listener Pick of the Week
Ricardo - MiniPCR
Eli - Let's outsmart Ebola together AND The Ebola virus explained
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Host: Vincent Racaniello
Guests: Kartik Chandran, Ganjam Kalpana, and Margaret Kielian
Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.
Links for this episode * Antibodies that protect against Sudan virus (ACS Chem Biol) * Ebola virus entry requires NPC1 (EMBO J) * A toggle switch for virus entry (Nat Comm) * Imaging alphavirus exit (J Virol) * Defects in HIV-1 unable to interact with INI1 (Retrovirol) * Cell cycle arrest by INI1 (Mol Cell Biol) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.
Links for this episode * Ebola virus update (WHO) * Norovirus can replace functions of gut microbiome (Nature) * Post-vaccinal distemper encephalitis (N Z Vet J) * Novel sea otter poxvirus (J Wildl Dis) * Poliovirus escapes antibodies (virology blog) * CDC whistleblower saga (Sci Based Med) * Snopes on CDC whistleblower * Image credit * Letters read on TWiV 313 * Video of this episode - view at YouTube
Weekly Science Picks
Alan - Retrocomputing
Rich - Where is Rosetta?
Vincent - Antares rocket explosion
Listener Pick of the Week
Simon - Relatively Prime
Mark - Giant Microbes
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episode * Ebola virus appropriations (White House) * ASM Ebola FAQ * Quarantine due to Ebola virus in semen (NPR) * Enteric bacteria promote norovirus infection of B cells (Science) * Norovirus emerges (Zimmer) * Stephanie Karst on TWiV 134 * Image credit * Letters read on TWiV 312
Weekly Science Picks
Alan - How Ebola airlifts workKathy - Fred Murphy's Foundations of Virology
Rich - Pendulum wave
Dickson - Young Dipterists
Vincent - Microbes After Hours: Ebola and TWiV iPhone 6 case
Listener Pick of the Week
Alane - Health Map
Todd - Formaldehyde in vaccines
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Zhen Fu and Biao He
Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses.
Links for this episode
- Blood-brain permeability and rabies survival (Antiviral Res)
- Rabies induces blood-brain permeability (J Virol)
- Virus neutralizing antibodies in CNS of non-lethal rabies (PLoS Neg Trop Dis)
- RSV vaccine based on PIV5 (Vaccine)
- New mumps vaccine (J Virol)
- PIV5-based influenza virus vaccine (J Virol)
- Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Glenn Rall
Guest: Ann Skalka
Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses.
Links for this episode * Skalka laboratory * Asilomar Conference on recombinant DNA * Unexpected inheritance (PLoS Path) * Viral sequences in vertebrate genomes (J Virol) * Assembly of integrase multimers (J Biol Chem) * Cell cycle and retrovirus integration (J Cell Bioch) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episode * Guidelines for monitoring potentially infected persons (CDC) * ASTMH meeting rejects attendees from Ebola countries (ScienceInsider) * Defense Threat Reduction Agency call for Ebola virus proposals * NSF calls for Ebola virus proposals * Review of Ebola virus human-human transmission (CDC) * How Firestone controlled Ebola virus (MMWR) * Could Reston virus be a vaccine for Ebola virus? (virology blog) * Letters read on TWiV 309
Weekly Science Picks
Alan - CDC Influenza activity weekly mapsKathy - Going Deep with David Rees
Rich - Virology Special Issue: Giant Viruses
Dickson - Nikon Small World Winners
Vincent - TWiM #90 and Republicans are not scientists
Listener Pick of the Week
Paul - Tricks and Tools of Great Scientists
Yegor - Hardcore History
Amanda - Vaccine ingredients; Anti-vaxers damage; Minds of anti-vaxers
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Tom Solomon
Tom talks with Vincent about viral central nervous system infections of global importance, Ebola virus, and running the fastest marathon dressed as a doctor.
Links for this episode * World's biggest brain * Tom's YouTube channel * Sex, drugs, and emerging viruses (TedX) * The Running Mad Professor * Image credit: ClickLiverpool * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Guest: Tara C. Smith
Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episode * Science communications fellow at ASM * Nation turns to science (New Yorker) * CDC employees in West Africa (CDC) * UN botched Ebola response (AP) * Ebola czar (CNN) * Ebola vaccine and budget cuts (HuffPo) * Collins' ridiculous meme (NOT junk) * How to quarantine against Ebola (Mukherjee) * Ebola fear in Heartland (Tara Smith) * Massive mutations in Ebola virus (PunditFact) * Ebola airport screening (CDC) * What is contact tracing? (video) (CDC) * Inside MSF Ebola unit (YouTube) * Ebola tech bulletin (DuPont) * HAI controversies * Letters read on TWiV 307
Weekly Science Picks Alan - Fall foliage mapKathy - Interviews with Peter Piot (one, two) and autobiography Vincent - The Ebola connection
Listener Pick of the Week
Brooke - N.B. Designs on Etsy
Victor - SMBC
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episode * Science communications fellow at ASM * CDC Ebola virus fact sheet (pdf) * CDC Ebola virus infographic (pdf) * No Reston virus replication in arthropods (Am J Trop Med Hyg) * Inoculation of plants and animals with Ebola virus (Emerg Inf Dis) * Arthropod studies during Ebola virus outbreak (J Inf Dis) * Medbox: Ebola toolbox * Facts about bushmeat and Ebola (pdf, CDC) * Should US ban incoming flights from West Africa? * Survey: should flights from Ebola countries be banned? (NBC News) * Ebolavirus content at virology blog and TWiV * Volunteer to help with the Ebola virus crisis * Ebola and Anthropology webinar * Asymptomatic Ebola virus infection (Lancet) * Persistence of Ebola virus during 1995 outbreak (J Inf Dis) * Assessment of Ebola virus transmission risk (J Inf Dis) * Ebola virus transmission risk factors (Emerg Inf Dis) * UV inactivation of Ebola virus (J Virol) * Ebola virus persistence in darkness (Arch Virol) * UV sensitivity of Ebola virus (Arch Virol) * Treatment of Ebola virus infection with brincidofovir (virology blog) * Ebola virus in domestic animals (Dev Biol) * Ebola virus in dogs (Emerg Inf Dis) * Ebola screening at US airports (CDC) * Letters read on TWiV 306
Weekly Science Picks Alan - The Sixth Extinction by Elizabeth KolbertKathy - Seeing the Invisible Vincent - 2014 Scientific American Science in Action Award winner
Listener Pick of the Week
Mauricio - Investigating a mystery disease
Heather - Diversity Journal Club
Johnye - Flu Attack!
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episode * Science communications fellow at ASM * Can we get AIDS from mosquito bites? (J La State Med Soc) * Why mosquitoes cannot transmit AIDS * Isolation of Bundibugyo ebolavirus in Uganda (PLoS Path) * Ebola virus disease outbreak, Nigeria (MMWR) * Nigeria contains Ebola virus outbreak (NY Times) * First Ebola virus case in US (NY Times) * Ebola virus disease: USA ex Liberia (ProMedMail) * First imported Ebola virus case in US (CDC) * Assessing risk of spread of Ebola virus (PLoS Currents) * How contagious is Ebola virus? (NPR) * Estimating reproductive index of Ebola virus (PLoS Currents) * Polio-like illness, EV-D68 suspected (ProMedMail) * Polio-like illness, North America (ProMedMail) * Four deaths associated with EV-D68 (NY Times) * Image credit: Pigott et al eLife * Letters read on TWiV 305 * Video of this episode - view at YouTube
Weekly Science Picks Alan - Under the knife, episode 1Kathy - UCSC Ebola genome portal Vincent - Annual Review of Virology, volume 1
Listener Pick of the Week
Alan - H5N1
Peter - Vomiting Larry
Dara - I just can't wait for my vaccine!
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Guest: Jeff Shaman
The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episode * Science communications fellow at ASM * Estimating future cases in Ebola virus epidemic (MMWR) * Columbia prediction of Ebola outbreak * The Ebola emergency (NEJM) * Q&As on Ebola virus transmission (CDC) * Ebola virus transmission to monkeys (Lancet) * Aerosol infection of monkeys with Ebola virus (Int J Exp Path) * Ebola virus replication in pigs (J Inf Dis) * Pathology of aerosol Ebola virus infection in rhesus macaques (Vet Path) * Murine model of Ebolavirus infection (Viruses) * Ebola virus transmission from pigs to non-human primates (Sci Rep) * Transmission risks in BSL4 laboratory (Sci Rep) * Why Ebola virus is unlikely to go airborne (Vox) * Letters read on TWiV 304
Weekly Science Picks
Alan - Fabre's Book of InsectsKathy - Origami microscope for 50 cents
Dickson - Landsat 8 Vincent - Some advice from Jeff Bezos
Listener Pick of the Week Justin - Brazil releases 'good' mosquitoes to fight dengue fever
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome.
This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.
Links for this episode * 2014 Ebola virus outbreak at Healthmap * Ebola virus transmission from bodily fluids and fomites (JID) * Value of gain of function experiments (mBio) * Rich Condit in the Washington Post on Ebola virus * NPR on Ebola virus transmission * What we are not afraid to say about Ebola virus (virology blog) * Inhibition of Borna disease virus by an endogenous element (PNAS) * Bornavirus at ViralZone * Photo: Thirteen-lined ground squirrel (image credit) * Letters read on TWiV 303
Weekly Science Picks
Alan - PhotogrammarKathy - Refrigerate your tomatoes?
Dickson - Robot swarm Vincent - The Beginner's guide to winning the Nobel Prize by Peter Doherty
Listener Pick of the Week
Dee - Publish scientific research faster on TWiST
Basel - Lego microscope (vote for it)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68.
Links for this episode * Cancer patient saved by measles virus * Ebola virus genome sequences (Science) * Robert Garry on Ebola outbreak * Aerosol transmission * WHO Ebola outbreak summary * CDC Ebola outbreak page * Ebola outbreak epi curve * CED Ebola outbreak info graphic * Ebola response roadmap (CDC) * Ebola outbreak discussion at ICAAC * Human trial of Ebola virus vaccine (CNN) * Chimpanzee adenovirus vectored Ebola virus vaccine (Nat Med) * How US Ebola patients were cured (Sci Amer) * Ebola outbreak could affect 20,000 (NY Times) * Ebola infection control resources * NLM free access to Ebola papers * Science Ebola papers open access * Gates donates money for Ebola outbreak (Wash Post) * Smuggled bushmeat? (Newsweek) * What we are not afraid to say about Ebola (NY Times) * Enterovirus D68 outbreak (MMWR) * Mark Pallansch on EV-D68 (NPR) * Enterovirus D68 (CDC) * EV-D68 isolation 1962 (Am J Ep) * Outbreak of enterovirus 68 (virology blog) * Letters read on TWiV 302
Weekly Science Picks
Alan - Index to creationist claimsRich - Wild KrattsKathy - Worn away
Dickson - Iceland volcano eruption Vincent - Immune Quest
Listener Pick of the Week Kay - Landes Bioscience open access books
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Host: Vincent Racaniello
Guests: Carla Saleh and Curtis Suttle
At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth.
Links for this episode * Greatest biodiversity on Earth (Genome) * Cafeteria roenbergensis virus (PNAS) * Marine viruses (Nat Rev Micro) * RNAi and reverse transcription is antiviral in flies (Nat Imm) * Friendly persistent infections (Curr Op Micro) * RNAi and antiviral defense in Drosophila (Dev Comp Imm) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Recording together for the first time, the TWiV team celebrates their 300th recording at the American Society for Microbiology headquarters in Washington, DC, where Vincent speaks with Dickson, Alan, Rich, and Kathy about their careers in science.
Links for this episode * So Happy Together (The Turtles) * Viral Hemorrhagic Fever Consortium * Support Kenema VHFC program * Letters read on TWiV 298 * Video of this episode - view at YouTube
Weekly Science Picks
Alan - The Internet's Original Sin
Dickson - PlacidcoyoteRich - Scientific Method, Grail StyleKathy - Viruses Throughout Life and Time Vincent - ALS Ice Bucket Challenge
Listener Pick of the Week
Jim - iBiology
Victoria - Images of Science
Mehul/Walt - Calling the Shots
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Marshall Bloom, Sonja Best, and Byron Caughey
Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases.
Links for this episode * Rocky Mountain Laboratories, NIH * Flavivirus persistence (Path Dis) * Flaviviruses antagonize IRF1 (J Imm) * Prion test using nasal brushings (NEJM) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV gang answer follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of disseminated multiple myeloma with oncolytic measles virus.
Links for this episode * Use of unregistered interventions for Ebola virus disease (WHO) * Response to anthrax and H5N1 incidents (CDC) * Remission of disseminated cancer after treatment with oncolytic measles virus (Mayo Clin Proc) * New viruses for cancer therapy (Nat Rev Micro) * Cattaneo on TWiV * Image credit * Letters read on TWiV 298
Weekly Science Picks Alan - WTF, Evolution?! by Mara GrunbaumRich - Cold Spring Harbor Oral History CollectionKathy - Inside insides Vincent - Going Viral (Rocky Mountain Ballet Theatre)
Listener Pick of the Week
Kim - Nobel Prize Podcasts
Johnye - The Planet is Fine
Jennie - Counter-Zombie Dominance Plan (pdf)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline.
Links for this episode * Risks and benefits of gain-of-function experiments (mBio) * Scientists for Science * US Policy for oversight of DURC (pdf) * US framework for guiding H5N1 transmission expts (pdf) * Extra oversight for H7N9 experiments (Science) * TWiV 283: No Reston for the weary * Is it Ebolavirus or Ebola virus? (virology blog) * Ebola virus disease update (WHO) * Ebola virus disease FAQ (WHO) * Ebola hemorrhagic fever (CDC) * Ebola virus disease: ecology meets economy (PLoS NTD) * 2014 Ebola virus outbreak (J Gen Virol) * 2014 Ebola virus outbreak (MMWR) * If Ebola virus came to the US (Vox) * Zaire ebolavirus in West Africa (interview with Tom Solomon) * Why Ebola patients were brought to US (Wash Post) * Experimental treatment and vaccines for Ebola (CDC) * Aerosol transmission of Reston virus (Sci Rep) * Ebola - A growing threat? (NEJM) * On the cusp of Ebola vaccine (Know) * Ebolavirus vaccines and antivirals (virology blog) * Immune responses to Ebolavirus infection (Exp Rev Clin Imm) * Antibody therapy for Ebola (Hum Vacc Immunother) * Plant derived monoclonals protect macaques from Ebolavirus (PNAS) * Anti-ebolavirus monoclonal cocktail (Sci Trans Med) * ZMapp info sheet (pdf) * ZMapp PR (pdf) * High tech treatment for Ebola (ArsTechnica) * ZMapp protects macaques (Sci Rep) * Letters read on TWiV 297
Weekly Science Picks Alan - Historical perspective on Ebola (Tara C Smith)Rich - Tell the negative committee to shut up (Fanuel Muindi)Kathy - Art of Night (Vimeo) Vincent - Is Ebola virus going to kill me? (John Skylar)
Listener Pick of the Week
Peter - Dr. Michael Saag interview by Dr. Virginia Campbell
David - PI Predictor (app, article, publication)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Linfa Wang
Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses.
Links for this episode * Hendra virus vaccine (Emer Inf Dis) * Comparison of bat genomes (Science) * Endogenous retroviruses in bats (Retrovirol) * The Bat Pack * Bats in Geelong (YouTube) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.
Links for this episode
- miRNA strategy to minimize risk (Nat BioT)
- NIH Office of Science Policy
- NIH recombinant DNA guidelines
- Second receptor for Lassa virus entry (Science)
- Lassa fever (Wikipedia)
- Fever! The discovery of Lassa virus (TWiV 9)
- Letters read on TWiV 294
Weekly Science Picks
Alan - Nicky Bay macrophotography (Flickr)Rich - FASEB Third annual BioArt competition Vincent - Up Close podcast (vrr episode)
Dickson - Science fun (YouTube)
Listener Pick of the Week
Mark Martin - Average bacteriophage
Konrad - Scholarpedia
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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members.
Links for this episode * Newly discovered smallpox (CDC) * Infectious smallpox in FDA storage (FDA) * Report on potential anthrax exposure (pdf, CDC) * CDC Director on unsafe practices (NY Times) * HIV returns to baby (NY Times) * Original HIV baby cured article (NEJM) * Cambridge Working Group * NSABB members released (ScienceInsider) * Letters read on TWiV 294
Weekly Science Picks
Alan - OptivisorRich - Noller lab ribosome movies Vincent - Creepy dreadful wonderful parasites
Dickson - National Center for Science Education
Listener Pick of the Week
Mark - The Machinery of Life by David Goodsell
Basel - iBioEducation
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Melissa Churchill, Alex Khromykh, Gilda Tachedjian, and Paul Young
Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus.
Links for this episode * Where does HIV hide? (Curr Op HIV AIDS) * Subgenomic flavivirus RNA (Viruses) * Vaginal lactic acid and HIV (J Antimicro Chem) * Koala retroviruses (Retrovirology) * Coming soon - Video of this episode at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Wade Blair, Matt Dickson, Nicole Kallewaard-Lelay, and Ken Miller
Vincent visits Medimmune and speaks with Wade, Matt, Nicole, and Ken about why they work in industry and their daily roles in a biotechnology company.
Links for this episode * Medimmune, LLC * Medimmune on Twitter * Medimmune history and products * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Clodagh O'Shea and Ron Fouchier
Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado.
Links for this episode * Viral polymer that inactivates tumor suppressors (Cell) * Mutations driving airborne transmission of influenza H5N1 virus (Cell) * Transmission of influenza H7N1 virus in ferrets (J Virol) * Ron Fouchier on TWiV #177 * Photo credit: Matt Evans * Thanks to David Quammen for the title * Video of this episode - view at YouTube
Weekly Science Picks
Rich - No sexual transmission of HCV (Am J Gastro) Vincent - Made with code (blog post)
Kathy - Beautiful math images (and 50 Visions of Mathematics)
Listener Pick of the Week
Jon - Advances in Life Sciences winners (YouTube)
Dave - Adam Ruben
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Janet Butel and Rick Lloyd
Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress.
Links for this episode * SV40 microRNAs (PLoS Path) * SV40 seroprevalence (J Infect) * Viruses and stress granules (PLoS Path) * Viral inhibition of stress granule formation (Cell Host Micr) * Video of this episode - view below or at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more.
Links for this episode * Varun's research poll * Letters read on TWiV 289
Weekly Science Picks
Alan - The Science of Good Cooking Vincent - The Shooter Report (pdf)
Kathy - Daily overview
Dickson - Girl rising
Listener Pick of the Week
Johnye - Ri channel
Ricardo - Open spin microscope (Nikon gallery, plans)
Chris - The microbiome game
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells.
Links for this episode * Should variola virus be destroyed? (poll at virology blog) * DNA complementary to non-retroviral RNA viruses (Sci Rep) * Integration of arenavirus DNA into cell genome (virology blog) * Infectious respiratory syncytial DNA (PNAS) * Tysabri and PML * JC and PML (J Imm Res) * Igor Koralnik laboratory * Jean-Luc Doumont (Kathy's pick, TWiV 268) * Bullet points kill (TED) * Letters read on TWiV 288
Weekly Science Picks
Rich - LuvalampsAlan - Experiment Vincent - American Society for Virology on Facebook
Kathy - LEGO female scientists
Dickson - The Oldest Living Things in the World by Rachel Sussman
Listener Pick of the Week Basel - A Treatise on the small-pox and measles by Abu-Bakr Al-Razi
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Matt Frieman
Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens.
Links for this episode * MERS stories at CIDRAP * MERS at CDC * MERS in the US (CDC) * MERS-CoV map * MERS-CoV infection after camel exposure (EID) * MERS-CoV in dromedaries from Egypt, Sudan, Ethiopia (EID) * MERS-CoV antivirals (one, two, three, four) * Experiments with novel potential pathogens (PLoS Med) * Unacceptable risks (Bull Atom Sci) * TWiX Bingo (thanks, Mark!) * Letters read on TWiV 287
Weekly Science Picks
Matt - Forgive me, scientists Alan - Do not link Vincent - bioRxiv
Kathy - Snail photographs
Dickson - Solar roadways
Listener Pick of the Week Daniel - Benz Biome concept car
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Alan Dove
Guests: Julie Pfeiffer and Paul Duprex
Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus.
Links for this episode * Threading the NEIDL (YouTube) * Transmission of measles virus from macaques (J Gen Virol) * Tropism of green measles virus in macaques (J Virol) * Intestinal microbiota promote enteric virus replication (Science) * Bacterial LPS enhances poliovirus stability (Cell Host Micr) * Video of this episode - view below or at YouTube
Weekly Science Picks
Vincent - ASM Live 2014
Alan - I will not follow the herd
Paul - Invisible Threat
Julie - The importance of stupidity in biological research
Listener Pick of the Week Neil - WEHI movies and VIZBI
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: XJ Meng and Sarah McDonald
Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses.
Links for this episode * Hepatitis E virus (Int J Env Res Pub Health) * Porcine and human anelloviruses (J Virol) * Origin of porcine epidemic diarrhea virus in US (mBio) * Distinguishing rotaviruses (J Virol) * Molecular epidemiology of rotaviruses (J Virol) * Core domains in rotavirus polymerase encapsidation (J Gen Virol)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed.
Links for this episode * Skin scarification protects against vaccinia virus disease (J Virol) * Smallpox research agenda (PLoS Path) * WHO report on variola research (pdf) * Review of smallpox research program for WHO (pdf) * How I record my lectures (virology blog) * Letters read on TWiV 284
Weekly Science Picks
Rich - EPCOT Vincent - Medical Biotechnology
Kathy - Alan Alda interview and Flame Challenge winner
Dickson - NASA live from space
Listener Pick of the Week
Nicola - 50 cent microscope (be a beta tester)
Jon - Camtasia Studio
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Guest: Jens H. Kuhn
Jens speaks with the TWiV team about filoviruses, including the recent Ebola virus outbreak in Guinea.
Links for this episode * Review of Zanamavir clinical trials (Brit Med J) * Ebola virus disease in Guinea (NEJM) * Filovirus nomenclature (virology blog) * Ebola virus disease, West Africa (ProMedMail) * How lethal are ebolaviruses? (virology blog) * Letters read on TWiV 283
Weekly Science Picks
Alan - AMNH digital special collections Vincent - Viral entry into host cells (Stefan Pöhlmann PhD, Graham Simmons PhD, eds)
Kathy - Papilloma song lyrics (pdf)
Jens - The Logic of Chance by Eugene V. Koonin
Listener Pick of the Week
Joe - Poor showing of 2012 influenza vaccine (Nature)
Phil - Emerging disease or emerging diagnosis? (YouTube)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws.
Links for this episode * World Malaria Day * Review of oseltamivir clinical trials (Brit Med J) * Effectiveness of Tamiflu questioned (NHS choices) * Tamiflu campaign (Brit Med J) * Rescuing US biomedical research (PNAS) * Letters read on TWiV 282
Weekly Science Picks
Alan - Northampton Airport Vincent - Particle Fever
Kathy - Turn iPhone into microscope
Rich - My favorite science gifs
Listener Pick of the Week Nathan - The Ascent of Man (YouTube)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Peter L. Salk
Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk's 100th birth anniversary.
Links for this episode * Jonas Salk Legacy Foundation * The Cutter Incident by Paul Offit * Splendid Solution by Jeffrey Kluger (review) * Coming soon: Video of this episode
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVmeisters answer listener email about the NEIDL, negative results, patenting MERS-coronavirus, human papillomavirus transmission, canine distemper virus, and much, much more.
Links for this episode * Poxvirus viability in historical relics (EID) * TWiM 74: It came from the Siberian permafrost * How to read a scientific paper * Image credit: Not only quilts * Letters read on TWiV 280
Weekly Science Picks
Alan - Heartbleed explanation Vincent - Agriculture science today podcast
Kathy - Quizlet flashcards (online and iTunes)
Rich - Why nothing is truly alive
Listener Pick of the Week
Lance - Myles Power (YouTube and Facebook)
Raihan - Cheap DIY microscope
Gerald - DaVinci Press
Neal - I'm a virus
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body.
Links for this episode * Retrovirus needed for stem cell identity (Nat Struc Mol Biol) * HERV-H is a marker for pluripotency (Retrovirology) * Letters read on TWiV 279
Weekly Science Picks
Alan - Heathkit Vincent - How to think about autism risk andAutism prevalence
Kathy - Distortions
Listener Pick of the Week
Joseph - The real process of science
Marion - Zometool
Kevin - Audioimmunity and Emmunity
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1.
Links for this episode * Gene editing of ccr5 in AIDS patients (NEJM) * HIV gets the zinc finger (TWiV 144) * Genome engineering with zinc finger nucleases (Genetics) * Photo credit: Watty's Wall Stuff * Mice lie, monkeys exaggerate t-shirt design (thanks, Christophe) * Letters read on TWiV 278
Weekly Science Picks
Alan - Digital scale model of solar system
Dickson - Font of knowledge Vincent - Measles outbreaks trends, and NYC measles (one, two)
Kathy - Winner, funding basic science to revolutionize medicine
Listener Pick of the Week
Stephen & Jon - Watty's Wall Stuff
Johyne - Macro views of snowflakesRicardo & Stephen - Vaccine exemptions
Bill - Books by John Janovy
Marshall - Animation of DNA replication
Steve - Debunking influenza vaccine myths
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Glenn Rall, Ann Skalka, and Vincent Racaniello
Glenn and Ann meet up with Vincent to talk about his career in science and science communication.
Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Susan Baker and Thomas Gallagher
Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses.
Links for this episode * Papain-like viral proteases (Virus Res) * MERS-CoV papain-like protease (Virology) * Mouse model for MERS-CoV (PNAS) * Receptor and MERS-CoV infection (J Virol) * Letters read on TWiV 276 * Video of this episode - view at YouTube
Weekly Science Picks Vincent - First demonstration of Macintosh, 1984
Listener Pick of the Week Lance - The Signal and the Noise by Nate Silver
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Rich Condit
Guest: Eugene Koonin
Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life.
Links for this episode * Virocentric view of evolution (Curr Op Virol) * Proposed order Megavirales (Arch Virol) * Pithovirus (PNAS) * Selfish virus-like elements (Virol J) * Pandoraviruses are derived Phycodnaviruses (Biol Direct) * Video of this episode - view below at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces.
Links for this episode * MERS-CoV in dromedary camels (EID) * Virologist Al Kapikian dies * Polio-like illness in CA (ProMedMail) * Acute flaccid paralysis * AFP in India (EID) * Enterovirus 68 (MMWR) * EV 68 CNS infection (Arch Path Lab Med) * Polio-free does not mean paralysis-free (The Hindu) * Viruses in 14th century coprolite (AEM) * Coprolite and paleofeces * Ancient poxvirus (EID) * Giant coprolite (WordADay) * Letters read on TWiV 274
Weekly Science Picks
Alan - The science of science communication Rich - Command and Control by Eric Schlosser
Dickson - Top 10 plant viruses Vincent - Is the Nobel Prize good for science?
Kathy - Time to rethink graduate and postdoc education (YouTube)
Listener Pick of the Week
Jon - Lessons from a Kansas graveyard
Mike - Cross a fashion designer with a microbiologist
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: W. Ian Lipkin and Thomas Briese
Vincent meets up with Ian and Thomas to discuss their finding that MERS-coronavirus has been circulating in dromedary camels in the Kingdom of Saudi Arabia since at least 1992.
Links for this episode * MERS-CoV in dromedary camels (mBio) * TWiV 251: Don't kiss the camel * TWiV 247: Today's weather in virology * TWiV 239: Filterable camels
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler
The TWiVome dissect the finding that interferon lambda alleles predict the outcome of hepatitis C virus infection.
Links for this episode * Interferon lambda and HCV outcome (Cell Host Micr) * Laser capture microdissection (Wikipedia) * HCV dependent fluorescent reporter (Nat Biotech) * Bats and viruses (PLoS Path) * White nose syndrome (PLoS Path) * Mouse phenome database * Letters read on TWiV 273
Weekly Science Picks
Rich - Think like a scientist (one, two); Science controversies
Dickson - Visualization challenge 2013 Vincent - Orphan Black
Kathy - Alberta worm invasion project
Listener Pick of the Week
Timothy - How do vaccines cause autism?
Anne - Luke Jerram's glass viruses
Jim - NLM Communications Engineering Branch
Steve - Synapse by synapse Jacob - Tiny technology creates a buzz
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team describes aphid control by using a viral capsid protein to deliver a spider toxin to plants, and a human endogenous retrovirus that enhances expression of a neuronal gene.
Links for this episode * Toxin delivery to plants by viral capsid protein (Nat Biotech) * Pea enation mosaic virus (ViralZone) * Image credit: Aphid membrane feeding chamber (Sci Rep) * Aphid feeding chamber (YouTube) * Parafilm (Wikipedia) * Human endogenous retrovirus enhances neural gene (PNAS) * Flu, common cold, alternative medicine (NCCAM) * Cold vs flu (CDC) * Phage hunters * Bed bugs and infectious disease (PLoS Path) * Letters read on TWiV 272
Weekly Science Picks
Alan - Statistical error (Nature)
Rich - 12 oldest animal species
Dickson - When liquids collide Vincent - HIV denial and just asking questions
Kathy - Sun's canyon of fire
Listener Pick of the Week
Sandra - Women physicists keep female students psyched
Judi - HHMI's Biointeractive
Jacob - Influenza virus HA
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Ashlee Bennett
The TWiV crew discusses two reports on viruses that might have crossed kingdoms, from plants to honeybees and from plants to vertebrates.
Links for this episode * Tobacco ringspot virus in honeybees (mBio) * Plant virus that switched to vertebrates (PNAS) * CDC influenza activity and surveillance * With Esmeralda at ASM Biodefense (jpg) * Image credit: Virginia Tech Learning Resources Center * Letters read on TWiV 271
Weekly Science Picks
Alan - Nagasaki bombing (YouTube)
Rich - GoPro Red Bull Stratos (YouTube)
Dickson - Solar orbs Vincent - Socrative
Listener Pick of the Week
Basel - Pathology course online
Russell - Sochi 2014: Encyclopedia of spending
Yegor - Visual Science
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Rich Condit
Guests: Dennis Hruby and Yoshihiro Kawaoka
Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC.
Links for this episode * ASM Biodefense Meeting * Influenza H5N1 transmission (Virus Res) * Aerosol transmission of H5N1 virus in ferrets (Nature) * Characterization of H7N9 virus from humans (Nature) * ST-246 efficacy in primates (AAC) * Antiviral options for biodefense (Curr Op Virol) * ST-246 safety in humans (Antimicrob Agents Chemother) * Gain-of-function experiments (Science) * Letters read on TWiV 270 * Video of this episode - view at Vimeo
Weekly Science Picks
Vincent - Quanta Magazine
Rich - Colour is in the eye of the beholder
Listener Pick of the Week Kehau - Beautiful but deadly viruses
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16.
Links for this episode * IFI16 is a nuclear pathogen sensor (Cell Host Micr) * Nuclear IFI16 sensing of and antagonism by herpesvirus (PNAS) * Acetylation regulates IFI16 location (PNAS) * Letters read on TWiV 269
Weekly Science Picks
Kathy - Female conveners and speakers
Alan - Sandgrains
Rich - 2013 Lamborghini Aventador
Vincent - Happy Birthday Mac and 128K Mac teardown
Dickson - Farmdominion
Listener Pick of the Week
Peter - The Microscope and The Next Global Killer
Richard - Glass viruses
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Ashlee Bennett
Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity.
Links for this episode * How viruses cause disease (Coursera) * How clean is your iPad (Which?) * Meeting announcement: From emerging to pandemic viruses * CaMV virus factories involved in aphid transmission (J Virol) * Caulimovirus (ViralZone) * CaMV responds instantly to vector (eLIFE) * Aphid acquiring CaMV (J Virol) * Bat genomes, flight, and immunity (Science) * Letters read on TWiV 268
Weekly Science Picks
Kathy - Jean-Luc Doumont (slides, communicating science, website, Scitable)
Alan - Wireless thermometer
Vincent - LORiOLA viral necklaces
Listener Pick of the Week
Jessica - Knit icosahedron
Robert - Practical computing for biologists by Haddock and Dunn
Stephen - Fourteen years of US weather (YouTube)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy review a protease essential for influenza pathogenesis in mice, and directionality of rhinovirus RNA exit from the capsid.
Links for this episode * Protease essential for influenza pathogenesis in mice (PLoS Path) * Rhinovirus uncoating is directional (PLoS Path) * Fluorescence correlation spectroscopy * Capillary electrophoresis (Wiki) * Letters read on TWiV 267
Weekly Science Picks
Kathy - Amazing maps
Alan - Florida to NJ in 156 seconds (YouTube)
Rich - Whiteout over Great Lakes from Space
Vincent - LORiOLA viral necklaces
Listener Pick of the Week
Carol - Knit picornavirus
Robert - RNA: Life's Indispensible Molecule by James Darnell,
and Biochemical Pathways by Michal and Schomburg
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis.
Links for this episode * We should hunt for viruses in space (New Scientist) * I had my DNA picture taken (NY Times) * CD4 cell death by pyroptosis (Nature) * Abortive HIV infection in lymphoid tissue (Cell) * IFI16 sensor required for HIV mediated cell death (Science) * PubMed Commons * Preferential CTL targeting of Gag (Cell Rep) * Exonic transcription protein binding (Science) * Letters read on TWiV 266 * Video of this episode - view at YouTube
Weekly Science Picks
Kathy - 17 mundane things, mind blowing views
Alan - Snowovel
Vincent - Public's views on human evolution
Listener Pick of the Week Emily - Dengue pillow
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
In their final episode of the year, the TWiV team reviews ten compelling virology stories from 2013.
Links for this episode * Antiviral RNAi (TWiV 255, 256, 263) * MERS-CoV (TWiV 215, 223, 224, 233, 239, 247, 251, 258) * Placental trophoblasts confer viral resistance (TWiV 241) * Origin of REV (TWiV 248) * Phage T7 gets a cat scan (TWiV 220) * It's a cGAS! (TWiV 222) * Dual virus-host arms race (TWiV 242) * Pandoraviruses (TWiV 246, 261) * CMV based SIV vaccine (TWiV 254) * Threading the NEIDL * Letters read on TWiV 265 * Video of this episode - view at YouTube
Weekly Science Picks
Kathy - Women in Science
Alan - Contagium
Rich - RC helicopter (demo)
Vincent - The athletic power of quadcopters
Listener Pick of the Week
Lindsay - Alcohol consumption and vaccines (Vaccine)
Johnye - The Singing Microbiologist
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more.
Links for this episode * Viral gifts * Controlling plant viruses by vector control (Ann Rev Phyto) * Flavivirus RNAi suppressor (J Virol) * Entre probetas podcast (iTunes) * Hedgehog central * Reprogramming T cells for leukemia therapy (NEJM) * Petri Dish podcast * On Your Mind podcast * Letters read on TWiV 264
Weekly Science Picks
Kathy - Sorting algorithms visualized
Alan - Stratodean
Rich - Art in Science by Polyxeni Potter
Vincent - Pixel Genes
Listener Pick of the Week Judi - Olympus BioScapes Winner
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Ben tenOever
Ben joins the TWiV team to reveal the winner of his contest in which influenza viruses carrying different interferon-stimulated genes vie against one another in mice.
Links for this episode * Virusninja * Game of clones (Vax Rep) * Game of clones bracket * Letters read on TWiV 263
Weekly Science Picks
Kathy - The Brain Scoop, esp. Where My Ladies At
Alan - Say 'hi' to a spaceship (YouTube)
Rich - Garmin BlueChart Mobile and Active Captain
Vincent - Journal boycott (one, two)
Dickson - Futurescape TV show
Listener Pick of the Week
Luis - Spillover by David Quammen
Ken - Gravity
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guest: Ann Palmenberg
Vincent returns to the University of Wisconsin - Madison to speak with Ann Palmenberg about her career in virology.
Links for this episode * Palmenberg lab website - great resources * Genome sequences of all rhinoviruses (J All Clin Imm) * Cardioviral poly(C) tracts (Arch Virol Supp) * EMCV disruption of nuclear transport (PNAS) * Picornavirus protease in replicase gene (J Virol) * Bacteriophage Qbeta replicase (J Virol) * Thanks to Jordan for the episode title! * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and James Van Etten
Guests: Chantal Abergel and Jean-Michel Claverie
Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus.
Links for this episode * Unanswered giant virus questions (Adv Virus Res) * Fourth domain of life (Commun Integr Biol) * Pandoraviruses (Science) * Phaeocystis globosa virus (PNAS) * Cafeteria roenbergensis virus (PNAS) * Symposium group photo (jpg) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Tom Friedrich, Tony Goldberg, and David O'Connor
Vincent visits the University of Wisconsin, Madison and speaks with Tom, Tony, and David about their work on virus discovery at the AIDS Vaccine Research Laboratory.
Links for this episode * A tick in Tony's nose (Am J Trop Med Hyg) * Two new SIV from colobus monkeys in Uganda (Biomed Cent) * Pegivirus diversity in Uganda (J Gen Virol) * Simian hemorrhagic fever virus diversity in African primates (J Virol) * Video of this episode - coming soon
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Rich Condit
Guest: Jaquelin Dudley
Vincent and Rich join Jackie at the University of Texas, Austin to talk about her work on mouse mammary tumor virus.
Links for this episode * Rem signal peptide processing and function (J Virol) * MMTV null mice and tumorigenesis (J Virol) * Jackie's publications (PubMed) * I want my MMTV (TWiV 242) * Live at ASV in Madison (TWiV 193) * Symbiotic safecrackers (TWiV 154)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Matt Frieman
Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus.
Links for this episode * SARS-like virus in bats binds ACE2 (Nature) * Bat SARS-like virus that infects human cells (virology blog) * Coronavirus infections update (WHO) * Lack of MERS coronavirus antibodies in humans (EID) * Mice not susceptible to MERS-CoV (J Gen Virol) * MERS-CoV case imported into Spain * MERS-CoV like virus in European hedgehogs (J Virol) * DPP4 amino acids positively selected in bats (Virol J) * Image credit: Richie Frieman * Letters read on TWiV 258
Weekly Science Picks
Kathy - Optical illusion (YouTube)
Alan - Amboceptor
Matt - Reply all by Richie Frieman (audio sample) Vincent - The microbiology of beer
Listener Pick of the Week
Cassie - NeatoShop
Peter - Synapse evolution with Seth Grant (BSP 101)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team consider how the kinase mTOR modulates the antibody response to provide broad protection against influenza virus, and explore the problems with scientific research.
Links for this episode * Two lives intertwined (Ann Rev Imm) * John Holland, 83 * Kinase mTOR modulates antibody response (Nat Imm) * Drug widens immunity to flu (TheScientist) * Concerto in B (TWiV 161) * How science goes wrong (Economist) * Trouble at the lab (Economist) * Reforming science (TWiV 184) * Letters read on TWiV 257
Weekly Science Picks
Dickson - Tesla Motors supercharger Kathy - FASEB contest: Stand out for science
Alan - Natural History Museum virtual tour
Rich - Mauna Kea heavens Vincent - FAA expands use of electronics on planes
Listener Pick of the Week Peter - Score and ignore (pdf)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Dickson, Alan, Rich, and Kathy review two papers that present evidence for RNA interference as an antiviral immunity mechanism in mammals.
Links for this episode: * World Polio Day * Mole Day * John Holland's publications * RNAi is antiviral in mammals (Science) * Antiviral RNA interference in mammals (Science) * RNAi, antiviral after all (Science) * Is RNA interference antiviral in mammals? (Cell Host Microbe) * Nodamura virus (Nature) * Ebolavirus proteins suppress RNAi (J Virol) * Illustrated is an siRNA (orange), dicer (top right), and argonaute (bottom) * Letters read on TWiV 256
Weekly Science Picks
Dickson - Wildlife Photographers of the Year 2013 Kathy - John Holland's Emerging Infectious Disease lecture (YouTube)
Alan - The worst part is not
Rich - The Universe in a Single Atom by Dalai Lama (Mind and Life Institute) Vincent - The Truth about T. Rex by Brian Switek
Listener Pick of the Week Stephen - International Institute for Species Exploration (Top 10 species choice)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Rich Condit
Guests: Robert Krug and Christopher Sullivan
Vincent and Rich visit the University of Texas at Austin and meet up with Bob and Chris to talk about their work on influenza virus and microRNAs.
Links for this episode: * Virus-encoded microRNAs (PLoS Path) * microRNA targetomes of polyomavirus (J Virol) * Innate and RNAi reciprocal inhibition (Cell) * ISG15 pathway (Trends Micro) * Role of viral NS1 protein (Virology) * Cap-snatching (Cell)
Weekly Science Picks
Rich - Unraveling Bolero
Vincent - New botulinum toxin, DURC implications, and inconvenient truths
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy review clearance of simian immunodeficiency virus infection from macaques by immunization with SIV proteins encoded in a rhesus cytomegalovirus vector.
Links for this episode: * Immune clearance of SIV infection (Nature) * Rhesus CMV vectors (Nature Medicine) * Types of memory T cells (WikiPedia) * Goldilocks approach to vaccines (Scilogs) * Chimeric HA influenza vaccine (J Virol) * Influenza vaccine matched vs mismatched (BMC Medicine) * Letters read on TWiV 254
Weekly Science Picks
Dickson - The Man Who Planted Trees by Jean Giono Kathy - A boy and his atom and Moving Atoms (YouTube)
Alan - It is pitch dark and Get Lamp (YouTube)
Vincent - Who's afraid of peer review? (Science)
Listener Pick of the Week
Maren - Hello Maestro (episodes on YouTube)
Ayesha - Why you don't f** love science
Jon** - A Capella Science (YouTube)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
In this second consecutive all-email episode, the complete TWiV team reads questions and comments from listeners about systemic antiviral responses, wild type poliovirus in Israel, Turkish scientists, viral symbiotes, and much more.
Links for this episode: * One Nation in support of biomedical research? * Bilim Kazani (The Cauldron of Science) * Science for Gezi * State of Turkish Science * Pathogenesis of feline coronavirus (EID) * Dinosaurs plagued by infection (PLoS One) * Dinosaur renaissance (WikiPedia) * Birds are dinosaurs (AMNH) * Influenza vaccine enhances disease in pigs (Sci Transl Med) * Gut microbes influence B-cell development (Nature) * Circovirus in dogs (EID) * We the microbiologist * Letters read on TWiV 251
Weekly Science Picks
Dickson - HD slow motion montage (YouTube) Kathy - Damselflies and Eyewitness app
Alan - Space weather forecast (YouTube)
Rich - 1984 by George Orwell (Doublethink)
Vincent - PopSci comments off and Why so few women in science?
Listener Pick of the Week
Meika - Flip action roll (YouTube)
CN - Blink: The Power of Thinking without Thinking by Malcolm Gladwell
Bernadeta - Higgs Boson wins Nobel Prize
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team reads email from listeners about anti-vaccine activists, a career in microbiology, placentas, a virology textbook, the HeLa cell genome, norovirus, and much more.
Links for this episode: * Anthropic principle * 1999 vaccine article by Alan Dove (Nature) * Image credit: Jason Roberts * Letters read on TWiV 251
Weekly Science Picks
Dickson - A Sand County Almanac by Aldo Leopold Kathy - Noctilucent clouds and aurora over Scotland
Alan - Flu vaccination map
Rich - There's a fly in my urinal
Vincent - Picornaviridae.com
Listener Pick of the Week
Peter - PDB-101
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV crew reviews work on MERS-coronavirus, including serological studies in camels, production of an infectious DNA clone, and identification of an interferon antagonist.
Links for this episode: * Stephan Chron dies (NY Times) * Philip Marcus dies (NY Times) * Philip Marcus on TWiV #197 * Ellen Fanning dies (news@Vanderbilt) * Donald Low dies (CBC News) * MERS timeline * MERS-CoV seroepidemiology (Eurosurveillance) * MERS-CoV neutralizing antibodies in camels (Lancet Inf Dis) * MERS-CoV vaccine candidate (mBio) * MERS-CoV infectious DNA (PNAS) * MERS-CoV protein 4a is IFN antagonist (J Virol) * Letters read on TWiV 251
Weekly Science Picks
Dickson - Scharf Photo Kathy - Blaschka glass models (NY Times, Cornell)
Alan - Digital Public Library of America
Rich - Dengue virus life cycle animation
Vincent - Creative Live
Listener Pick of the Week
John - Last person to get smallpox (NPR)
Peter - SARS documentary (BBC)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Robert Garcea
Vincent and Robert recorded this episode at the 53rd ICAAC in Denver, where they talked about polyomaviruses.
Links for this episode: * A cornucopia of human polyomaviruses (Nat Rev Micro) * Polyoma assembly factories in nucleus (PLoS Path) * Overprinting gene in Merkel cell polyomavirus (PNAS) * Human JCV as population marker (PLoS One) * Letters read on TWiV 250 * Video of this episode (YouTube)
Weekly Science Picks Robert - The Panic Virus by Seth Mnookin Vincent - Aliens chestburster behind the scenes
Listener Pick of the Week
Adam - Virology Fact of the Day
Christophe - dr Karl
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Vincent, Dickson, Alan and Rich discuss an estimate of the number of different mammalian viruses on Earth.
Links for this episode: * Estimate of unknown viral diversity in mammals (mBio) * How many viruses on Earth? (virology blog) * Letters read on TWiV 249
Weekly Science Picks Alan - Extreme macrophotography Dickson - Baloney detection kit Rich - Mutant silkworms spin colored silk (original article) Vincent - FlightRadar24
Listener Pick of the Week
Jenn - Ebola by William Close
Jenn - Eleven Blue Men by Berton Roueche
Nissin -Profiles in Science
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
Vincent, Dickson, and Rich reveal how experiments with a malaria parasite lead to the introduction of a mammalian retrovirus into birds.
Links for this episode: * Scientists cast doubt on MERS origin (NY Times) * Animal reservoirs of SARS coronavirus (Virus Res) * Jo Handelsman in the White House * Origins of REV (PLoS Biology) * Inadvertent transfer (virology blog) * Mongoose, pheasant, pox, retrovirus (PLoS Biol) * Evolutionary history of REVs * Amazing story (Ed Yong) * My wife's P. lophurae paper (Mol Bio Parasitol) * William Trager's SNV paper (Exp Biol Med) * EBV detection tests (Clin Diag Lab Immunol) * Letters read on TWiV 248
Weekly Science Picks Dickson - Google Sky Rich - Vanishing of the Bees (see also Bee Apocalypse Now) Vincent - Not Exactly Rocket Science
Listener Pick of the Week Saira - Reproducibility Initiative
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Special guest: Ian Lipkin
Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus.
Links for this episode: * MERS-CoV in bats (EID) * Mystery virus (NY Times) * Part of MERS-CoV found in bat (virology blog() * T. perforatus * Frag virus (Virol J) * Even Nature got it wrong! (Nature) * Bats: Important reservoirs of emerging viruses (Clin Micro Rev) * Letters read on TWiV 247
Weekly Science Picks
Kathy - Rainbows explained (Frazz) Alan - Challenge.gov Vincent - 23andme
Rich - Spot the station
Listener Pick of the Week Frank - Pacifier cleaning practices and risk of allergy development (Pediatrics)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence.
Links for this episode: * Pandoraviruses (Science) * Unlike anything seen before (virology blog) * H7N9 gain of function experiments planned (Nature, Science) * Virologists plan H7N9 gain of function experiments (virology blog) * Creating a deadly virus? Not!! (USA Today) * HeLa cell genome sequence (Nature) * NIH Director explains HeLa agreement (Nature) * HeLa deal (Nature) * Biospecimen policy (Nature) * Sequencing HeLa the right way (turbidplaque) * Skloot on HeLa deal (The Scientist) * HeLa deal (NY Times, USA Today) * Picture on Condit's wall (EID) * Letters read on TWiV 246 * Video of this episode - view below or at YouTube
Weekly Science Picks
Kathy - GeoGuesser Alan - From one, many (YouTube) Vincent - Dave Bhella: The Wildy Award Talk (Microbeworld video)
Rich - 1981 primitive internet report (YouTube)
Listener Pick of the Week CN - How the Mind Works by Steven Pinker
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: S. Jane Flint, Lynn Enquist, Glenn Rall, and Ann Skalka
The authors of the popular textbook Principles of Virology discuss how the book was conceived and written.
Links for this episode: * Principles of Virology * Lahiere's * General Virology by SE Luria
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Alan Dove
Guests: Dan Barouch and Jeff Teigler
This episode of TWiV was recorded before an audience at the Beth Israel Deaconess Medical Center, where Vincent and Alan spoke with Dan and Jeff about AIDS vaccines.
Links for this episode: * Human study of adenovirus 26 HIV-1 envelope vaccine (J Inf Dis) * Seroepidemiology of adenovirus serotypes (Vaccine) * SIV infection associated with expansion of gut virome (Cell, TWiV #204) * Global approach to HIV-1 vaccine development (Immunol Rev) * Innate cytokine responses to adenoviruses (J Virol) * microRNAs as mediators of viral evasion (Nat Immunol) * Letters read on TWiV 244
Weekly Science Picks
Jeff - Science in the News; How to succeed in science (part one and part two) Alan - Nanostructure flowers
Vincent - Scientific culture
Listener Pick of the Week Basel - The sequester blues
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Guests: Rebecca Dutch and Christiane Wobus
On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses.
Links for this episode: * TWiV 143 with Stephanie Karst * American Society for Virology * Mouse model for human norovirus (mBio) * Paramyxovirus fusion (Viruses) * Photo credit: Matt Evans
Weekly Science Picks
Kathy - Shuffling cards Vincent - Dave Bhella - Electron cryomicroscopy
Rich - Seven-year postdoc
Listener Pick of the Week Judi - Reading for science literacy
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein.
Links for this episode: * Dual virus-host arms race (PLoS Biology) * Dual virus-receptor duel (see comments - virology blog) * Ferritin and transferrin (Protein Data Bank) * Money for nothing (YouTube) * Letters read on TWiV 242
Weekly Science Picks
Dickson - Mantid images Kathy - No email? (phd comics) Alan - The turbid plaque Vincent - AAM Faq: West Nile Virus
Rich - Science is awesome
Listener Pick of the Week
Luis - Public Health Image Library
Stephen - Hopkins closes graduate science-writing program
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933.
Links for this episode:
- Human placental trophoblasts confer viral resistance (PNAS)
- Placental circulation (Wikipedia)
- Ovum in uterine decidua (Wikipedia)
- A virus obtained from influenza patients (Lancet)
- 80 years ago today (the guardian)
- Influenza: Exposing the true killer (J Exp Med)
- Letters read on TWiV 239
Weekly Science Picks
Matt - The Kid Should See This Alan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)
Rich - Sydney Brenner (Web of Stories)
Listener Pick of the Week
Joe - Grand challenges in science education (Science)
Mark - Weather Underground
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Host: Vincent Racaniello
Guests: Markus Thali and Jason Botten
Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses.
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman
Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus.
Links for this episode: * MERS-CoV update (WHO) * MERS-CoV evolution (epidemic) * Sick camel linked to MERS-CoV death (7Days) * MERS-CoV hospital outbreak (NEJM) * MERS-CoV French hospital cluster (Lancet) * MERS-CoV family cluster (NEJM) * Matt on MERS-CoV on the Voice of Russia * Letters read on TWiV 239
Weekly Science Picks
Matt - The Kid Should See This Alan - Cassini to photograph Earth Vincent -Cockroaches! (YouTube)
Rich - Sydney Brenner (Web of Stories)
Listener Pick of the Week Ebrahim - Virus Hunter by CJ Peters and Mark Olshaker
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells.
Links for this episode: * Slides for this episode (pdf) * T7 ribosomal binding sites (CSH Symp Quant Biol) * Tinkering with translation (CSH Persp) * Translation at nexus of infection and immunity (Cell Host Microbe) * Viral subversion of protein synthesis machinery (Nat Rev Micr)
Weekly Science Picks
Kathy - Vaccine-preventable outbreaks Rich - To Catch a Virus by John Booss and Marilyn J. August
Vincent - This is Water by David Foster Wallace
Listener Pick of the Week
Jon - Confessions of a converted lecturer by Eric Mazur
Peter - FameLab
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Rich Condit
Guest: Michael Emerman
Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis.
Links for this episode: * Ancient origins of SIV (PLoS Path) * Paleovirology (PLoS Biology) * Harmit Malik on TWiV 205 * Sara Sawyer on TWiV 193
Listener Pick of the Week Molly - Facts in the case of Dr. Andrew Wakefield
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection.
Links for this episode: * Ultraprotective influenza vaccine in mice (PNAS) * Vectored immunoprophylaxis of influenza in mice (Nat Biotech) * Intranasal antibody gene transfer protects agains influenza (Sci Transl Med) * Estimating influenza associated deaths (CDC) * Multistate HAV outbreak (CDC) * Subscribe to Microbeworld video (YouTube) * Save podcasting (EFF) * Letters read on TWiV 236
Weekly Science Picks
Alan - Psychology of antivaccinationists Vincent - Virology on Coursera
Kathy - Meteorites through the ages
Listener Pick of the Week
Basel - Self-medication in animals
Sheryl - Noadi's art
Felicity - Survival of the Sickest by Sharon Moalem
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Rich Condit
Guests: Dave Evans, Stan Lemon, and Lorne Tyrrell
Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta.
Links for this episode: * Li Ka Shing Institute of Virology * Alberta Heritage Foundation for Medical Research * Raised on a farm (YouTube) * Vaccinia virus strains in Dryvax vaccine (J Virol) * Vaccinia DNA polymerase and recombination (J Virol) * Picornavirus hijacks cell membrane (Nature)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Kathy Spindler
Guests: Nels Elde and Tom Shenk
Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome.
Links for this episode: * A cross-species view on viruses (Curr Op Virol) * Pox has got a squeeze box (TWiV 198) * Saturated fatty acids needed for CMV (PLoS Path) * CMV and HSV metabolomes differ (PLoS Path) * Video of this episode - view at YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus.
Links for this episode: * Aerosol transmission of H1N1 x H5N1 reassortants (Science) * It's good science (virology blog) * Viral engineering dangers (Nature) * Colorblind web page filter * Influenza H7N9 update (ProMedMail) * Influenza H7N9 risk assessment (WHO, pdf) * Influenza H7N9 confirmed cases (WHO) * New coronavirus gets a new name (ScienceInsider) * Novel coronavirus infection update (WHO) * Coronavirus infections (WHO) * Letters read on TWiV 233
Weekly Science Picks
Alan - Space Oddity (YouTube) Rich - Walk through giant colon Vincent - Transport proteins
Kathy - Vomiting Larry (YouTube)
Listener Pick of the Week Tom - US patent system is broken (DailyTech)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Roberto Cattaneo, Reuben Harris, Lou Mansky, and Leslie Schiff
Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates.
Links for this episode: * University of Minnesota virology timeline * Revisiting HIV-1 lethal mutagenesis (Trends Micro) * Exploiting HIV-1 drug repositioning (J Virol) * 5-azaC induces HIV-1 lethal mutagenesis (J Virol) * HIV-1 fitness and mutation rate (J Mol Biol) * APOBEC3 mutagenesis in breast cancer (Nature) * Restriction factors of HIV (J Biol Chem) * Nectin-4 is epithelial measles receptor (Nature) * Photographs of this episode: Click here * Video of this episode - YouTube
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Amit Kapoor, Lan Quan, and Ian Lipkin
Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents.
Links for this episode: * Canine hepacivirus (TWiV 137) * Rodent homologs of hepaciviruses and pegiviruses (mBio) * Bats are a reservoir of hepaciviruses and pegiviruses (PNAS)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus.
Links for this episode: * Francois Jacob dies (The Loom) * WHO updates on H7N9 * H7N9 is unusually dangerous (ScienceInsider) * H7N9 case imported into Taiwan * No H7N9 in poultry farms (Xinhua) * Supreme Court considers gene patents (TheScientist, Nature) * Patent my jeans, not my genes (Michael Wosnick) * Receptor binding by ferret transmissible H5 virus (Nature) * Microscale thermophoresis and bio-layer interferometry (Wikipedia) * Letters read on TWiV 230
Weekly Science Picks
Alan - World Science Festival Rich - 3 years of the sun in 3 minutes Vincent - The Origin of AIDS by Jacques Pepin
Kathy - Wringing out a wet washcloth in space (YouTube)
Listener Pick of the Week
Mark - Will it blend? (iPhone app)
Marianne - Enjoy your Cells
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove
Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.
Links for this episode: * Hilary Koprowski, 96 (NY Times) * Koprowski, Kessin, Racaniello photo * Listen to the Music by Roger Vaughan * Influenza ocular infections (one, two) * H7N9 global concerns (NEJM) * Human infection with H7N9 (NEJM) * WHO Global Alert and Response, H7N9 * Avian influenza A(H7N9) virus (WHO) * Novel H7N9 reassortant, implications for Europe (Eurosurveill) * Genetic analysis of H7N9 (Eurosurveill) * H7N9 compared with H7N7 outbreaks (Eurosurveill) * Image credit: Eurosurveillance * Letters read on TWiV 229
Weekly Science Picks
Alan - Nature PastCast Rich - How dengue does it Vincent - Squeaky Squeegee Art by Deb Sklut
Dickson - Agritecture
Listener Pick of the Week Mike - Chemistry in its element: Elements and Compounds
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Britt Glausinger, and Eva Harris
Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus.
Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay.
Links for this episode: * RNA element in IL-6 confers SOX resistance (J Virol) * Dual uORFs regulate herpesviral translation (PLoS Path) * Common viral strategy for RNA degradation (J Virol) * KSHV SOX and Xrn1 together degrade host mRNAs (PLoS Path) * Dengue treatment with Fc null antibodies (PLoS Path) * Early clinical features of dengue in Nicaraguan children (PLoS Negl Trop Dis) * Intrahuman dengue virus diversity (J Virol) * Dynamics of dengue disease severity (Sci Transl Med)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus.
Links for this episode: * Containment plan for poliovirus (pdf, WHO) * Post-eradication of polio * Ocular tropism of respiratory viruses (MMBR) * Rally for medical research * HeLa genome sequence withdrawn (ScienceInsider) * Immortal life sequel (Rebecca Skloot) * HeLa genome sequence published, withdrawn (virology blog) * Vial of Guanarito virus missing (ABC news) * Human H7N9 infections (ProMedMail) * WHO H7N9 updates * China escalates H7N9 response (NY Times) * Brian Kimble on H7N9 * Compatibility of H9N2 and H1N1 genes (PNAS) * Letters read on TWiV 227
Weekly Science Picks
Kathy - NIAID YouTube videos
Alan - Lego insects Rich - How to see the world in a grain of sand Vincent - Vaccines, viruses, and the anti-vax movement
Dickson - Edinburgh Science Festival
Listener Pick of the Week
Stephen - Nature iOS app
Mehul - Voices for vaccines
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, and Terry Dermody
Vincent and Dickson speak with Terry Dermody about his career in medicine and virology.
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more.
Links for this episode: * Plant viruses alter insect behavior (Sci Rep) * Circovirus in Shanghai * Letters read on TWiV 225
Weekly Science Picks
Kathy - Case stories about CoV-EMC (one, two)Rich - The Self-Illusion by Bruce Hood
Vincent - Moving Targets
Listener Pick of the Week
Liam - eLIFE and Rubriq
Steve - Plant virus ecology (mp3)
Neil - World Immunization Week
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract.
Links for this episode: * Dipeptidyl peptidase 4 is CoV-EMC receptor (Nature) * Receptor for new coronavirus (Nature) * Broad reception for coronavirus (Nature) * SARS 10th anniversary (Science) * Interferon-epsilon protects female reproductive tract (Science) * Families fighting flu (YouTube) * Monitoring infections with online data (TWiM 41) * Natalie Portman was a scientist (NY Times) * Letters read on TWiV 223
Weekly Science Picks
Kathy - 2013 Intel Science Talent Search awards
Alan - Krebs Cycle Rap(CDC) Vincent - Jetpens (favorite one and two)
D ickson - Rabies death in organ recipients (CDC)
Listener Pick of the Week
Justin - The DNA Store
Jim - Massive Open Online Classrooms
Chris - Feedly
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells.
Links for this episode: * International Women's Day 2013 * Condit Dam, 6 weeks later (Vimeo) * Influenza HA assay * Covalent influenza NA inhibitors (ScienceExpress) * Defective influenza HA mutants (Virology) * New flu drug (BBC, e! Science) * EEEV antibody, RNA in snakes (Am J Trop Med Hyg) * EEEV (CDC) * Zoonotic potential of CoV-EMC (mBio) * CoV-EMC update (ProMedMail, CDC) * CoV-EMC travel update (CDC) * Letters read on TWiV 223
Weekly Science Picks
Kathy - Finkbeiner test and Women in Science
Alan - New flu vaccine efficacy study(CDC) Vincent - Threading the NEIDL video
Listener Pick of the Week
Steve - Prof. Joan Steitz on viral RNA
Ed - Archiving history of molecular biology: Press release, video, CSHL archives and videos
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.
Links for this episode: * Zhijian J. Chen (Wikipedia) * Sensing the dark side of DNA (Science) * cGAMP is an endogenous second messenger (Science) * cGAMP synthase is a DNA sensor (Science) * Pore-forming toxin (Wikipedia) * Letters read on TWiV 222
Weekly Science Picks
Kathy - Graphene batteries
Alan - How do we get cures? (YouTube) Rich - Explosive breach of Condit Dam (Vimeo) Vincent - 10 things you can do to support open access (Tree of Life)
Listener Pick of the Week
Mark - The real story of Stuxnet
John - D-connector virus
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler
Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV.
Links for this episode: * Human transmission of SFTSV (JID) * SFTSV serosurvey (EID) * SFTSV on TWiV 147 * SFTSV in Japan (ProMedMail) * SFTSV mouse model (PNAS) * SBV infectious DNA and mouse model (PLoS Path) * SBV in Sweden (ProMedMail) * Letters read on TWiV 221
Weekly Science Picks
Kathy - Winners, 2012 Science & Engineering Visualization Challenge
Vincent - The Operator and Dr. Oz's Problem
Listener Pick of the Week
Shane - OpenPCR
John - Python
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk.
Links for this episode: * Influenza splicing regulates infection (Cell Reports) * Reporting on flu splicing from NPR, BBC, NBC * Splicing of influenza RNA 8 (jpg) * Bacteriophage T7 remodeling during infection (Science) * Cryo-ET of intact cells (Trends Cell Biol) * T7: The Movie (YouTube) * Cry0-EM vs Cryo-ET (Wikipedia) * Virus caught in the act (e! Science News) * Letters read on TWiV 220
Weekly Science Picks
Kathy - Journal of Virology Image GalleryRich - Phage T7 Genetics and Physiology and slab gels
Alan - PeerJ (press release)
Vincent - Virologia en Español
Listener Pick of the Week Dave - Thingiverse pathogens and proteins
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, and Anthony S. Fauci
Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases.
Links for this episode: * Fauci history (J Clin Inves) * Fauci Pharmacy * Anthony Fauci (Wikipedia) * Anthony Fauci: Unfinished business (Lens)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Welkin Johnson
Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response.
Links for this episode: * Kuan-Teh Jeang, 54 * Resurrection of ERVs (Nature) * Toll-like receptors control ERVs (Immunity) * Retroviral danger from within (Immunity) * Ancient viruses wreak havoc (The Scientist) * Letters read on TWiV 218
Weekly Science Picks
Welkin - Viruses: Essential Agents of Life (review at STC)Alan - Infinity Imagined
Vincent - Spaceship built for son
Listener Pick of the Week
Amanda - Written? Kitten!
Kevin - Protein synthesis: An epic (YouTube)
Daria - The Baltimore Scheme
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Dickson Despommier
Vincent, Alan, Rich, and Dickson review influenza vaccines.
Links for this episode: * FDA licensed flu vaccines * Seasonal influenza vaccine distributed * How flu vaccine strains are selected (one, two) * WHO report on flu vaccine strain selection (pdf) * Derek Smith on antigenic mapping * Salk's 1945 influenza vaccine * TIV preparation: Fluzone, Agriflu, Fluvirin, Fluarix, Flulaval, Afluria (pdfs) * LAIV preparation (pdf) * Efficacy of flu vaccine 2012-13 (MMWR, virology blog) * Meta-analysis of flu vaccine efficacy (Lancet) * Two new flu vaccines FDA approved * Flublok * Flublok clinical trial * Pandemrix and narcolepsy (Yahoo, PLoS One, PLoS One) * CIDRAP analysis of flu vaccines * Letters read on TWiV 217
Weekly Science Picks
Rich - Repoopulate (original article), Robogut (new clinical trial)Alan - WTF, Evolution?
Dickson - The Beauty and Benefits of Science
Vincent - Supercomputing modeling of poliovirus
Listener Pick of the Week Bjorn, Marshall, Meaghan - Glass sculptures of Luke Jerram
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export.
Links for this episode: * Slides for this episode (pdf) * Spliced Ad 2 late mRNAs (Cell) * An amazing sequence arrangement (Cell) * Adenovirus late mRNA undecanucleotide (Cell) * Aaron Shatkin, 72 (virology blog) * Schrödinger's cat (Wikipedia) * Letters read on TWiV 216
Weekly Science Picks
Rich - Linus Pauling's explanation of science (YouTube)Alan - Underwater experiments
Kathy - I'm a virus (YouTube)
Vincent - Stem cells (Bizarro Comics)
Listener Pick of the Week
Tom - The President's Analyst
Danielle - Overly honest methods (HuffPost and ASBMB Today)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East.
Links for this episode: * Neuronal survival after rabies virus infection (PLoS Path) * Clusters of coronavirus cases (Nature) * ProMedMail on novel coronavirus * Novel coronavirus outbreak news (Int J Inf Dis) * Genomic characterization of novel coronavirus (mBio) * Broad cell tropism of novel coronavirus (mBio) * Are viruses alive? (poll at virology blog) * Antibodies taken up by endocytosis (PNAS) * Antibody eliminates alphaviruses from neurons (Science) * Image: Virus in the garden by Helen Hache * Letters read on TWiV 215
Weekly Science Picks
Alan - I'm a Scientist - The Film
Kathy - Humorous units of measurement (Wikipedia)
Vincent - Open access must enable open use (Nature)
Listener Pick of the Week Tarwin - Plague Inc.
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons.
Links for this episode: * Coagulation factor X activates innate immunity to adenovirus (Science) * A decorated virus cannot hide (Science) * Reflecting on goals for Science * Polyomavirus associated with raccoon brain tumors (EID) * MPNST * Moore tumor viruses - TWiV 160 * Treating CLL with lentivirus vectors (NEJM) * Letters read on TWiV 214
Weekly Science Picks
Alan - Parasite of the Day
Kathy - Tour of International Space Station
Vincent - Earth as Art
Listener Pick of the Week
Robin - Angell on Big Pharma
Michael - Flu jokes
Jim - Database of Ted talks; Downloadable Ted Talks
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
In their final episode of the year, the TWiV team reviews twelve cool virology stories from 2012.
Twelve virology stories from 2012: 1. H5N1 (TWiV 190, 182, 177, 173, 168) 2. Polymorphisms that control susceptibility (TWiV 175, 180) 3. New virus receptors (TWiV 166, 210) 4. XMRV: Last nail in the coffin (TWiV special) 5. Polio eradication troubles in Pakistan (NY Times one, two, three; virology blog) 6. Biomedical research crisis (TWiV 208, 184, 189, 194) 7. Polydnaviruses in parasitoid wasps (TWiV 179) 8. Carolyn Coyne’s placental barrier story (TWiV 193) 9. Touring NEIDL (TWiV 200) 10. Epidemiology (TWiV 169, 178) 11. A good year for virus hunting (173, 183,195, 196, 198, 199, 204) 12. Pox accordion (TWiV 198)
Links for this episode: * US plans for H5N1 research (ScienceInsider) * FDA recommends against Ampligen * Rituximab and CFS (PLoS One) * No evidence for XMRV in prostate cancer (PLoS One) * Retraction of XMRV prostate cancer paper (Retraction Watch) * Gender bias among science faculty (PNAS) * NEIDL risk assessment * Virology 101 at TWiV * Letters read on TWiV 213
Weekly Science Picks
Rich - Our Mr. Sun (IMDB entry) (wiki)Alan - PubReader from NCBI announcement and instructions
Kathy - Popular Mechanics 110 picks for the next 110 years
Vincent - 366 days: Nature's 10
Listener Pick of the Week Matt - The flu vaccine controversy
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Stuart Firestein
Vincent and Stuart discuss why ignorance - all of what we don't know, and even what we don't know we don't know - is the driving force of science.
Links for this episode: * Ignorance: How it drives Science by Stuart Firestein * Ignorance website
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
The TWiVerers answer listener email about genetically modified chickens, a hendra vaccine for horses, online education, curing color blindness, Roosevelt and polio, Th cells, and much more.
Links for this episode: * TWiV 116: Cocaine, colonies, and chickens * Glofish * Recombinant Hendra vaccine * Gene therapy for color blindness (Nature) * FDR, polio, and Guillain-Barré * Transcript of TWiV 197: Philip Marcus (pdf) * TWiV 10: Bats, elephants, and AIDS * TWiM 6: Phage therapy * TWiP 47: For whom the trich tolls * Viruses of protozoan parasites (virology blog) * Long in the tooth * Transcript of 'How to read a science paper' (pdf) * FEMA disaster preparedness courses * Letters read on TWiV 212
Weekly Science Picks
Rich - OverviewAlan - Notes towards the complete works of Shakespeare
Kathy - Correlation vs. Causation (#1, #2, #3)
Vincent - Periodically inspired
Listener Pick of the Week
Mark - Life of a Nature paper
Ricardo - Things don't go viral
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Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler
The TWiV four discuss an mRNA-based influenza vaccine, and a phage tubulin that forms a filamentous array in the host cell that is needed for positioning viral DNA.
Links for this episode: * mRNA vaccine against influenza (Nat Biotech) * Phage tubulin assembles dynamic filaments (Cell) * Viral skeleton (The Scientist) * Not unorganized bags of enzymes (TWiM 28) * Bacterial cytoskeleton (FEMS Micro Rev) * Triangulation number (jpg) * Letters read on TWiV 211
Weekly Science Picks
Rich - Ocean Global Shark TrackerAlan - The Field Book Project
Kathy - How to manipulate an army of zombies
Vincent - Science sculpture
Listener Pick of the Week Stephen - WEHI.TV
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathy Spindler
The complete TWiV team reviews identification of the cell receptor for hepatitis B and D viruses, and the cell enzyme that cleaves the genome-linked protein from picornaviral RNA.
Links for this episode: * HBV and HDV cell receptor (eLIFE) * Getting to grips with hepatitis (eLIFE) * Sodium taurocholate * Poliovirus hijacks DNA repair enzyme (PNAS) * Letters read on TWiV 210
Weekly Science Picks
Rich - Vendée GlobeDickson - Earth at nightAlan - Trophée Jules Verne
Kathy - Science cookies
Vincent - Trilobite Glassworks
Listener Pick of the Week
Ken - Spanish flu pandemic model (teacher's guide)
Jim - Santa Cruz Science Communication Program (also see SHERP)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler
Vincent, Dickson, Alan, and Kathy answer listener email about deformed wing virus, West Nile virus, FluMist, influenza in Canada, viruses and the tree of life, and more.
Links for this episode:
- Postcard from the ultimate student athlete (pdf)
- Fidelity of protein synthesis (Biochemistry, 5th ed.)
- Letters read on TWiV 209
Weekly Science Picks
Dickson - Cassini web site and Mars reconnaissance orbiterAlan - OneZoom Tree of Life
Kathy - Viral tumor suppressor structure (Cell) Vincent - Spot the Station
Listener Pick of the Week
Ricardo - Once upon a time: The possible story of viruses
Jim - Encode, myIDP, Experiment Reproduction podcasts
Mark - MoMath
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello and Jon Yewdell
Vincent and is joined by special guest Jon Yewdell to discuss solutions for ending the current crisis in American biomedical research.
Links for this episode: * How to succeed in science: Taking the plunge (Nat Rev Mol Cell Biol) * How to succeed in science: Making discoveries (Nat Rev Mol Cell Biol) * How to succeed in science (YouTube) * Resources for graduate students and postdocs * Science career cartoons by Alexander Dent
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler
Vincent, Alan, Matt, and Kathy review the use of silk to stabilize antibiotics and a viral vaccine, and an impaired-fidelity vaccine against SARS coronavirus.
Links for this episode: * Silk stabilization of antibiotics and vaccines (PNAS) * Impaired-fidelity coronavirus vaccine (Nature Medicine) * Select agent status and SARS therapies (Spoonful of Medicine) * Letters read on TWiV 207
Weekly Science Picks
Matt - Virus-associated pyramids (slide #11)Alan - Similarities of wave behavior (YouTube)
Kathy - The glass transition Vincent - US cattle country in uproar at virus lab plans (BBC)
Listener Pick of the Week
Ricardo - Blackawton bees and Science is for everyone (TED)
Tony - Biophilia by Bjork
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv
Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Kathy Spindler
Vincent, Alan, Dickson, and Kathy discuss how the innate immune response to viral infection influences the production of pluripotent stem cells, and the diverse mobilome of giant viruses.
Links for this episode: * Innate immunity and nuclear reprogramming (Cell) * Viruses affect cell reprogramming (The Scientist) * Cell-penetrating peptides (Trends Mol Med) * Provirophages and transpovirons (PNAS) * Organic Lake photo and map * Letters read on TWiV 206
Weekly Science Picks
Alan - Locust by Jeffery A. LockwoodDickson - Nikon Small World Contest 2012
Kathy - Influenza Encyclopedia Vincent - Dengue fever sweeps India (NY Times)
Listener Pick of the Week Allison - Fred Guterl on The Daily Show
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv.
Hosts: Vincent Racaniello and Harmit Malik
Vincent is joined by special guest Harmit Malik to discuss his work on the evolution of genetic conflict.
Links for this episode: * Harmit on YouTube * Retroviruses and mammalian placentation (PNAS) * Paleovirology (Curr Opin Virol) * Evolution among AIM2-like receptors (J Exp Med) * Poxvirus genomic accordions (Cell) * Letters read on TWiV 205
Weekly Science Picks Vincent - Candidates' answers to science questions
Listener Pick of the Week Steve - Mural of Henrietta Lacks story (Microsoft Silverlight required)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Matt Frieman, and Kathy Spindler
Vincent, Alan, Matt and Kathy review isolation of a new coronavirus from two patients in the Middle East, and expansion of the enteric virome during simian AIDS.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * Novel coronavirus (virology blog one, two) * PCR assay for novel CoV (Eurosurveillance) * Isolation of novel coronavirus (NEJM) * SARS CoV now a select agent (Federal Register, pdf) * My Sharona * Pathogenic SIV infection associated with expansion of gut virome (Cell) * Letters read on TWiV 204
Weekly Science Picks
Alan - Map of the WindMatt - Dark Side of the Earth; Insensitive guide to thriving in your Ph.D.; Gary Vanerchuck (YouTube)
Kathy - How much does a shadow weigh? and Slinky drop answer Vincent - A Parasite's Parasites; All the cool kids are on arXiv
Listener Pick of the Week Nissin - Jungle Jim (1948)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Rich Condit, and Mark Challberg
Vincent and Rich meet up with Mark Challberg to talk about his scientific career studying viral DNA replication, and his transition to an NIH Program Officer.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * Purification of vaccinia virus DNA polymerase (J Biol Chem) * Adenovirus DNA replication in vitro (PNAS) * Herpes simplex viral genes required for DNA synthesis (J Virol) * Letters read on TWiV 203
Weekly Science Picks Rich - Mattel Hot Wheels Curiosity Rover Vincent - Should H5N1 Moratorium End?
Listener Pick of the Week Claudio - DIY lab equipment (Ars Technica) and DIY Bio
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, T. Jack Morris, James Van Etten, and Charles Wood
Vincent travels to the University of Nebraska to meet with members of the Nebraska Center for Virology and discuss their work on algal viruses, plant viruses, HIV and Kaposi's sarcoma herpesvirus.
Links for this episode: * The Nebraska Center for Viology * Behind the scenes at TWiV 202 * TWiV on Facebook
Weekly Science Picks Charles - Rhabdovirus associated with hemorrhagic fever (PLoS Path) Vincent - Bacteriophage graffiti (jpg)
Listener Pick of the Week
Bob - Remembering Penny Pinneo
Janet - Penn and Teller on vaccinations (YouTube)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy answer reader email about rabies, xenotransplantation, poliovirus, Ph.D. programs, mosquitoes, and much more.
Links for this episode: * Mattias Schnell * Novel rhabdovirus from Africa (Plos Path) * Milwaukee protocol (Wikipedia) * How lethal is rabies virus? (virology blog) * Issues with polio eradication (J Gen Virol) * Vaccine-derived polioviruses (J Inf Dis) * Global pandemics with Hidde Ploegh (Vimeo) * Polio vs Bin Laden (Alan Dove) * Letters read on TWiV 201
Weekly Science Picks
Alan - Wallace OnlineRich - World Rabies Day
Kathy - Yo-yos in space
Dickson - The Art in Science Vincent - The Podcasters Studio
Listener Pick of the Week
Wink - DuckDuckGo
Josh - Introduction to Solid State Chemistry
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Elke Mühlberger, Paul Duprex, and Ron Corley
Vincent, Alan, and Rich celebrate the 200th episode of TWiV by visiting the National Emerging Infectious Diseases Laboratories at Boston University Medical Center, where they meet with Elke, Paul, and Ron to talk about building and working in a BSL4 facility.
Links for this episode: * The NEIDL * NEIDL goes public (BU Today) * Biosafety levels (Wikipedia) * Select agents (Wikipedia) * NEIDL stalled (Boston Business J) * TWiV on Facebook * Letters read on TWiV 200
Weekly Science Picks Alan - Dance your Ph.D.Rich - Angel of Death by Gareth Williams Vincent - Why herpesvirus is good for you (Virgin lab)
Listener Pick of the Week Luis - VBORNET maps
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello and W. Ian Lipkin
Vincent and Ian review a multicenter blinded analysis which finds no association between chronic fatigue syndrome/myalgic encephalomyelitis and XMRV or polytropic murine leukemia virus.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * Multicenter blinded analysis of CFS and XMRV/pMLV (mBio) * Press release on multicenter study (pdf) * Press conference webcast * TWiV on Facebook
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy discuss recent outbreaks of hantavirus pulmonary syndrome in Yosemite National Park and novel swine-origin influenza in the US midwest, and isolation of the Heartland virus from two patients in Missouri with severe febrile illness.
Subscribe to TWiV (free) in iTunes, at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * Hantavirus outbreak in Yosemite (ProMedMail) * Hantavirus in Yosemite (CDC) * CDC page on hantavirus * Summary of hantavirus outbreak (Avian Flu Diary) * Swine-origin influenza outbreak in midwest (MMWR) * Lyn Finelli interview on swine-origin H3N2 (Microbeworld) * Transmission of vH3N2 in ferrets (PNAS) * New phlebovirus from Missouri (NEJM) * TWiV on Facebook * Letters read on TWiV 199
Weekly Science Picks
Alan - Insane in the Chromatophores (Vimeo)Rich - Golden Goose Awards
Kathy - Euler's Disk (YouTube) Vincent - Ignorance: How it Drives Science by Stuart Firestein
Listener Pick of the Week Adam - Leigh Van Valen
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
Vincent, Alan, Rich, and Kathy review fatal avian influenza virus in harbor seals, and poxvirus deployment of genomic accordions to counter antiviral defenses.
Links for this episode: * Avian influenza virus in harbor seals (mBio) * Poxvirus genomic accordions (mBio) * Red Queen hypothesis (Wikipedia) * TWiV on Facebook * Letters read on TWiV 198
Weekly Science Picks
Alan - Getting Better: 200 Years of MedicineRich - Khan Academy
Kathy - Vi Hart Vincent - Tweet Keeper
Listener Pick of the Week
Diane - The Way We Fall by Megan Crewe
Stephen - Amateur Micrography
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello and Philip I. Marcus
Vincent travels to the University of Connecticut to meet up with Professor Philip I. Marcus to discuss his development of the single cell cloning technique in the early 1950s.
Links for this episode: * Cloning with X-irradiated feeder cells (PNAS) * Philip I. Marcus in the lab (jpg) * Cloning with capillary tubes (jpg) * Cloning platform (jpg) * VRR holding 1950s glass plate of clones (jpg) * HeLa clones (jpg) * Cloning cylinder (jpg) * TWiV on Facebook * Coming soon: video of this episode
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Kathy Spindler, Mark Stenglein, and Joseph DeRisi
The TWiVites meet with Mark Stenglein and Joseph DeRisi to discuss their discovery of a novel arenavirus in snakes with inclusion body disease.
Links for this episode: * Highly divergent arenaviruses in snakes (mBio) * Taryn's sick snake (NPR) * Assemblathon * Faculty position in virology, Columbia U. * Petridish.org * TWiV on Facebook * Letters read on TWiV 196
Weekly Science Picks
Mark - The Slow Mo Guys (Fly eats fly) Dickson - I'm being eaten by a boa constrictor by Shel Silverstein Alan - MMWR: First 30 years onlineRich - Giant python in Everglades and California Academy of Sciences
Kathy - Darwin finch genome sequence Vincent - Microbiology at Mt. Sinai
Listener Pick of the Week
Renato - Security Now podcast
Robin - The Weather
Chad - Rare protozoan from sludge (ScienceDaily)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Ken Stedman
The complete TWiV team meets with Ken Stedman to discuss the discovery in Boiling Spring Lake of a DNA virus with the capsid of an RNA virus.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * Novel virus from an extreme environment (Biol Direct, virology blog) * Lassen Volcanic National Park * Tombusviridae, Circoviridae (ViralZone) * TWiV on Facebook * Letters read on TWiV 195
Weekly Science Picks Ken - The Edge of Life trailer and Facebook page Dickson - The Cognitive Style of Powerpoint by Edward Tufte Alan - SEMs of insects and spiders via Steve GschmeissnerRich - Curiosity Has Landed (Wiki mission summary) Vincent - Curiosity's Seven Minutes of Terror (YouTube)
Listener Pick of the Week
Lance - The Vaccine Confidence Project and Immune response video (YouTube)
Anat - Beautiful Science
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Matthew Daugherty, Jondavid deJong, Helen Lazear, Stefan Oliver, and Cara Pager.
Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * TWiV 189: Five postdocs in Glasgow * ASM at the USA Science and Engineering Festival * ASV 2012 at Madison, WI * Photographs of ASV 2012 * TWiV on Facebook
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Rich Condit, Carolyn Coyne, and Sara Sawyer
Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * ASV 2012 at Madison, WI * Photographs of ASV 2012 * Rock band Herpetic Legion plays at ASV 2012 * TWiV on Facebook * Letters read on TWiV 193
Weekly Science Picks Rich - Benjamin Franklin: An American Life by Walter Isaacson Vincent - Biochemistry Revealed
Listener Pick of the Week
Matlock - The BioDigital Human
Matt - Scientists create jellyfish from rat cells
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich answer listener email about bioinformatics, insects, influenza, laboratory classes, commensalism, reproducibility of data, and more.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * Vaccinia virus sequence from patient with vaccine complication (pdf) * The evolution of intellectual freedom (thanks, Robin!) * Free access to British scientific research (Guardian) * xTAG respiratory viral panel * Houston rabies case (Statesman) * Tertulia (Wikipedia) * TWiV on Facebook * Letters read on TWiV 192
Weekly Science Picks Alan - The Microbial Olympics (supplementary information)Rich - PharmaJet needle free injection system Vincent - Microbes and Evolution by Roberto Kolter and Stanley Maloy (paperback and Kindle)
Listener Pick of the Week
Varun - Agile Gene by Matt Ridley
Sizun - Plague Inc
Ricardo - TED-ED
Kristopher - Ed Yong on Econtalk
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Nissin Moussatche
Nissin joins the TWiV crew to discuss an outbreak of lethal disease among Cambodian children, and recombination among attenuated herpesvirus vaccines leading to pathogenic viruses.
Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.
Links for this episode: * Outbreak in Cambodia (CNN) * Pathogen mix in Cambodian illness (ProMedMail) * Undiagnosed illness in Cambodia (WHO) * Enterovirus 71 (virology blog) * Recombination among attenuated vaccines (Science) * An outbreak of irony (Ed Yong) * Infectious laryngotracheitis * Gallid herpesvirus 1 (Wikipedia) * Iltovirus (ViralZone) * TWiV on Facebook * Letters read on TWiV 191
Weekly Science Picks Alan - H5N1 genetic changes inventoryRich - Mythbusters: Diet Coke and Mentos (YouTube channel) Nissin - The Pox and the Covenant by Tony Williams, and Tired of War by Tereza Batista Vincent - FAQ: The 'snake bite' portion of your thesis defense
Listener Pick of the Week
Gopal - All's not fair in science and publishing
Luis - The Origin of AIDS by Jacques Pepin (Nature review)
Sven - Visualizing information flow in science
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
Vincent, Alan, and Kathy review selection of influenza H5N1 viruses that can transmit among ferrets by aerosol.
Links for this episode: * Airborne transmission of H5N1 among ferrets (Science) * Potential for H5N1 evolution (Science) * H5N1 (Science) * The ferrets of fear * Jim's podcast list (pdf) * TWiV on Facebook * Letters read on TWiV 190
Weekly Science Picks Kathy - Wind map Vincent - The A-Z of Epidemiology (YouTube)
Listener Pick of the Week
Kristoffer - How to read a paper
Neva - Electricity from viruses
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Vincent returns to the Centre for Virus Research at the University of Glasgow and meets with postdocs to discuss their science and their careers.
Links for this episode: * MRC-University of Glasgow Centre for Virus Research * Stop CMV * Photos of my Glasgow visit (Facebook and VirusTalk) * TWiV on Facebook
Hosts: Vincent Racaniello, Massimo Palmarini, John MacLauchlan, Emma Thomson, and Hande Harmanci.
Vincent travels to Scotland to meet with members of the Centre for Virus Research at the University of Glasgow to discuss their work on hepatitis C virus and jaagsiekte sheep retrovirus.
Links for this episode: * MRC-University of Glasgow Centre for Virus Research * Aaron Shatkin, 77 (virology blog) * Photos of my Glasgow visit (Facebook and VirusTalk) * TWiV on Facebook * Letters read on TWiV 188
Weekly Science Picks Vincent - Microbe art
Listener Pick of the Week Judi - Cell Imaging (Mac App Store)
Hosts: Vincent Racaniello and Rich Condit
Vincent and Rich discuss recovery of a hepatitis B viral genome from a 16th century Korean mummy, and personal omics profiling of an individual over a 14 month period.
Links for this episode: * Tracing HBV to the 16th century (Hepatology) * HBV on TWiV * Precautions with ancient DNA (Science) * Personal omics profile over 14 months (Cell) * A geneticist's research turns personal (NY Times) * Mike Snyder on Futures in Biotech * The DASH diet * TWiV on Facebook * Letters read on TWiV 187
Weekly Science Picks Rich - The Checklist by Atul GawandeVincent - Artologica
Listener Pick of the Week
David - Cracking your genetic code (Nova)
Josh - The nuclearization of biology is a threat to health and security (pdf)
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
The TWiV chiefs tackle reader email about how to pronounce Buda, Texas, grinding tree stumps, and much more.
Links for this episode: * Detecting antibodies or antigens by ELISA * Peter Wildy Prize * Biosafety levels * Baltimore classification at Viral Zone * TWiV on Facebook * Letters read on TWiV 186
Weekly Science Picks
Alan - World Wide Lightning Location Network
Rich - Steve Jobs by Walter IsaacsonVincent - The Ocelloid
Listener Pick of the Week
lafrenchfille - whatshouldwecallgradschool
Neva - Antiviral drugs by Carl Zimmer
Sergio - APSnet
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Vincent visits with members of the Department of Microbiology and Immunology at Northwestern University School of Medicine to discuss their work on herpesviruses and parainfluenzaviruses.
Links for this episode: * Longnecker laboratory * Herpesvirus deubiquitinase is neuroinvasive determinant (PLoS Path) * Paramyxovirus HN structure (PNAS) * TWiV on Facebook * Letters read on TWiV 185
Weekly Science Picks
Sarah - Breasts: A Natural and Unnatural History by Florence Williams
Andrew - The Strangest Man by Graham FarmeloVincent - Gates Grand Challenges in Global Health awards
Listener Pick of the Week Ed - Pursuit of Light (YouTube); MRC Biomedical Picture of the Day; It's okay to be smart
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Vincent, Rich, and Alan consider how to reform the scientific enterprise to make it more effective and robust.
Links for this episode: * Reforming science: Methodological and cultural reforms (Infect Immun) * Reforming science: Structural reforms (Infect Immun) * Sharp rise in retractions (NY Times) * Vannevar Bush * TWiV on Facebook * Letters read on TWiV 184
Weekly Science Picks
Alan - PubMed PubReMiner
Rich - Intentional Blindness (YouTube)Vincent - Vaccine infographic
Listener Pick of the Week Ken - Wattpad
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.
Connor joins the TWiV team to discuss bats as hosts for major mammalian paramyxoviruses.
Links for this episode: * NIH response to Osterholm letter (pdf) * Who's afraid of the big, bad bioterrorist? * Bats host major mammalian paramyxoviruses (Nature Comm) * TWiV on Facebook * Letters read on TWiV 183
Weekly Science Picks
Connor - Microbiology Twitter journal club Alan - Where the Wild Types Are (YouTube)
Rich - May 14th: Smallpox vaccination day
Dickson - Searching for pore-fection (Science)
Vincent - RRResearch
Listener Pick of the Week Stephen - Every Major's Terrible (xkcd)
Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Michael J. Imperiale
Michael joins the TWiV crew to discuss the recently published influenza H5N1 transmission paper and how it was viewed by the NSABB.
Links for this episode: * About the NSABB * The Kawaoka paper (Nature) * Mutant flu paper published (Ed Yong) * Osterholm letter (pdf) * US policy for dual research of concern (pdf) * TWiV on Facebook * Letters read on TWiV 182
Weekly Science Picks
Alan - 18th century shipping mapped
Rich - Brave New World by Aldous Huxley
Vincent - Air France 447 (Telegraph)
Listener Pick of the Week Josh - Vaccines course by Dr. Paul Offit
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
Vincent, Rich, and Kathy discuss Cotia virus, a new poxvirus, Orf virus infections associated with handling goats and lamb, and the innate immune response to prions.
Links for this episode: * Cotia virus (J Virol) * Human Orf virus exposures (MMWR) * IRF3 protects agains prion infection (J Virol) * A mad cow in America (virology blog) * Human orf (pdf) * Space shuttle flies outside my window (YouTube) * TWiV on Facebook * Letters read on TWiV 181
Weekly Science Picks
Kathy - Astronomy Picture of the Day (especially this and this)
Rich - Tom Lehrer Element Song (YouTube)
Vincent - Albert B. Sabin Archives
Listener Pick of the Week
Mark - Netter's Infectious Diseases by Elaine C. Jong and Dennis L. Stevens
Richard - Germs, Genes & Civilization by David P. Clark
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich review association of an interferon-induced protein with severe influenza, and stabilization of HCV RNA by a microRNA.
Links for this episode: * IFITM3 and severe influenza (Nature) * Genetics of flu susceptibiligy (EurekAlert!) * Stabilization of HCV RNA by Ago2-miR-122 (PNAS) * Clinical trial of anti-mIR-122 * TWiV on Facebook * Letters read on TWiV 180
Weekly Science Picks
Alan - Micro Empire (Vimeo)
Rich - Census of marine life
Vincent - Pinterest
Listener Pick of the Week Mark - The Secret Life of Plankton (YouTube)
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Gertrud Radu
Gertrud joins the TWiVoners to review how dengue virus infection of mosquitoes alters blood feeding behavior, and gene therapy as practiced by parasitoid wasps.
Links for this episode: * Renato Dulbecco, 1914-2012 (virology blog) * William Jarrett, 83 (thanks, Lynn Enquist) * Dengue virus infection of mosquitoes alters their behavior (PLoS Path) * Does dengue make mosquitoes thirstier for blood? (NY Times) * Polydnaviruses of braconid wasps (Science) * Making nice with viruses (Science) * Viral and wasp genes involved in symbiotic replication (J Virol) * Amazing parasitic wasp images * The Far Side cartoon on mosquitoes (gif) * TWiV on Facebook * Letters read on TWiV 179
Weekly Science Picks
Gertrud - Bat on a plane! (MMWR)
Alan - The Rings of Earth (YouTube)
Rich - Giant Magellan telescope
Vincent - Hepatitis C new drug pipeline
Listener Pick of the Week
Ricardo - Evolution: The Natural History of Animal Skeletons
Peter - Self-assembly line (YouTube)
The TWiValians meet up with Tyler Sharp for a discussion on the Epidemic Intelligence Service and controlling dengue.
Links for this episode: * 2010 dengue epidemic in Puerto Rico * Marshall Islands dengue outbreak (one and two) * Photo of Tyler by Loren Rodgers * TWiV shout-out by NPR and CIDRAP * NSABB reverses decision on H5N1 publication * TWiV on Facebook * Letters read on TWiV 178
Weekly Science Picks
Tyler - Co-infection with dengue and Leptospira (Emerging Inf Dis)
Alan - The Winged Scourge (YouTube)
Rich - Deepsea Challenge
Vincent - Why did a US advisory board reverse its stance? (Ed Yong)
Listener Pick of the Week
Sasha - Microfluidic Future
Adam - The Conversation
Jim - ENIAC Programmers Project
A discussion of avian influenza H5N1 transmission experiments in ferrets and novel bunyaviruses at the 2012 Spring Conference of the Society for General Microbiology in Dublin, Ireland.
Links for this episode: * Restricted data on H5N1 transmission (Science) * Novel bunyavirus in China (NEJM and TWiV 127) * Ten things about Schmallenberg virus (Microbiology Bytes) * NSABB reverses decision on H5N1 papers (virology blog) * TWiV on Facebook * Letters read on TWiV 177
Weekly Science Picks
Connor - Wellcome Trust Science Writing Prize 2012
Vincent - Thoughts on academic scientists giving media interviews
Vincent, Alan, and Rich answer listener email about MS, CFS, EBV, B cells, virii, influenza B, scientific papers, and more.
Links for this episode: * More than one way to skin a virus (comments) * Aerobie aeropress * Papers software * Vaccinia movies (one and two) * Lloyd Kozloff dies * BSL4 facilities * TWiV on Facebook * Letters read on TWiV 176
Weekly Science Picks
Rich - Alan Alda's Flame Challenge (NY Times article, Science editorial)
Alan - ChronoZoom
Vincent - Academic Publishing is Broken by Michael P. Taylor
Listener Pick of the Week
Joel - Fighting a dengue outbreak by Tyler M. Sharp (parts one and two)
Sven-Urban - Fooled by Randomness and The Black Swan by Nassim Nicholas Taleb
Vincent, Alan, and Matt discuss herpes simplex encephalitis in children with innate immune deficiency, and the local response to microneedle-based influenza skin immunization.
Links for this episode: * Herpes encephalitis in children with TRIF deficiency (J Clin Inv) * Toll-like receptor and cytosolic pattern recognition receptors * Skin responses to influenza microneedle vaccine (mBio) * Microneedles * Fluzone intradermal influenza vaccine * QDot nanocrystal technology * TWiV on Facebook * Letters read on TWiV 175
Weekly Science Picks
Matt - Phage and the Origins of Molecular Biology
Alan - Digital Imagine Institute
Vincent - iPad apps Goodreader and Notability
Listener Pick of the Week
Jane -Smoking Ears and Screaming Teeth by Trevor Norton
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich consider whether pet dogs might transmit human noroviruses, and an RNA virus microRNA that might be involved in oncogenesis.
Links for this episode: * Do pet dogs transmit human norovirus? (J Clin Virol) * RNA virus miRNA that mimics oncomiR (PNAS) * MicroRNA expression by an RNA virus (PNAS) * Lab safety stickers jpg (thanks, Jon!) * Amateur virologists (Zimmer, NY Times) * Genome at home (Wired) * Barbergators sing national anthem (YouTube) * TWiV on Facebook * Letters read on TWiV 174
Weekly Science Picks
Rich - NOAA Buoy Data
Alan - Autism's False Prophets by Paul Offit
Vincent - Media Mining
Listener Pick of the Week
Mark - How the West fueled the AIDS epidemic
Henry - Regenesis
Rick - Biopunk: DIY scientists hack the software of life by Marcus Wohlsen
The TWiVites discuss seroevidence for human infection with avian influenza H5N1, and the discovery of a new influenza virus in Guatemalan bats.
Links for this episode:
- Seroevidence for human H5N1 infection (Science)
- Mammalian-transmissible H5N1 (mBio)
- New information about ferret-adapted H5N1 (NY Times, virology blog)
- New influenza virus from fruit bats (PNAS)
- Elsevier abandons open access assault (The Scientist)
- Le virus le plus dangereux?
- TWiV on Facebook
- Letters read on TWiV 173
Weekly Science Picks
Ashlee – AskScience (Reddit)Michael - HealthMap (iPhone and Android app)
Rich – H5N1 research discussion at ASMBiodefense
Alan – El Yunque National Forest
Vincent – The Journal of Global Health
Listener Pick of the Week
Judi – NSF visualization challenge
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss atmicrobeworld.org and tag them with twiv.
Hosts: Vincent Racaniello and Kathy Spindler
Vincent and Kathy discuss how a virus may cause disease distant from its replication site, then review a day in the life of a senior microbiology professor.
Links for this episode: * Celsius vs Centigrade * Neuropathogenesis during polymicrobial infection (PLoS Pathogens) * Tetramer staining (pdf) * One * TWiV on Facebook * Letters read on TWiV 172
Matt joins the TWiVarians to review virus production in single cells and single virion genomics.
Links for this episode: * H5N1 results will be published (NY Times) * Virus production in single cells then and now * Single virion genomics (PLoS One) * Multiple displacement amplification (Wikipedia) * Ranavirus killing turtles, tadpoles in Maryland (Washington Post) * Three Dog Night * TWiV on Facebook * Letters read on TWiV 171
Alan, Rich, and Dickson discuss Edward Jenner's paper on cowpox vaccine, then move 200 years later to modern vaccines against norovirus, influenza H5N1, and more.
Links for this episode: * Norton Zinder, 83 (Reuters) * Jenner's cowpox vaccine paper (Bartleby, Gutenberg) * Norovirus VLP vaccine (NEJM) * Plant-grown H5N1 VLP vaccine (Reuters, PLoS One) * Plant-grown norovirus VLP * Hexavalent pediatric vaccine * TWiV on Facebook * Letters read on TWiV 170
Michael and the TWiV team review epidemiology basics, including fatality ratios.
Links for this episode: * Michael's blog and podcast * Epidemiology literature critique (PowerPoint) * Seven mistakes in epidemiology (ETE) * Snow cholera map * TWiV on Facebook * Letters read on TWiV 169
Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.
Links for this episode: * Vectored HIV immunoprophylaxis (Nature) * Vectored immunoprophylaxis - the Movie (YouTube) * Adeno-associated virus (Wikipedia) * In vitro evolution of H5N1 towards human receptor specificity (Virology) * Endogenous viral genes non-essential in chicken (Nature) * Rates of HIV transmission per coital act (J Inf Dis) * TWiV on Facebook * Letters read on TWiV 168
Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.
Links for this episode: * Niemann-Pick C1 is entry factor for HCV (Nature Med) * Ebola virus entry requires Niemann-Pick C1 (Nature one, two) * Nectin-4 is measles virus epithelial receptor (Nature, PLoS Pathogens) * An exit strategy for measles virus (Science) * On this day in history * TWiV on Facebook * Letters read on TWiV 166
Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.
Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.
Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.
Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.
The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi's sarcoma herpesvirus and Merkel cell polyomavirus.
Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.
Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.
A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.
Vincent, Rich, and Dickson review a meta-analysis on influenza vaccine, a killer virus in fungi that selects against RNAi, and the use of armed and targeted poxviruses for oncolytic virotherapy.
Vincent, Grant, Eurico, Paulo, Francisco and Janice discuss their work on bocavirus, infectious bronchitis virus, begamoviruses, and circoviruses at the Brazilian Virology Society meeting in Atibaia, São Paulo, Brazil.
Vincent, Alan, and Rich are very enthusiastic about two studies that show how gut bacteria help viral invaders.
Vincent, Alan, and Rich review an outbreak of rabies in arctic foxes and reindeer in Norway, and a prion that makes you go antiviral.
Vincent, Alan, and Rich cover the virome of raw sewage, and a baculovirus gene that causes caterpillars to climb to their doom.
Vincent, Dickson, and Rich meant to do an all-email episode, but first they review results of the Blood XMRV Scientific Research Working Group, and partial retraction of the paper associating XMRV with chronic fatigue syndrome.
Vincent, Rich, Mark, and Trine discuss science and medicine in journalism and the eradication of poliovirus at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).
Vincent, Philip, David, and Priscilla recorded this episode before an audience at the Harvard Virology Program Annual Retreat, where they discussed negative strand RNA viruses, a vaccine against herpes simplex virus type 2, lipidomics of viral infection, and science communication.
The complete TWiV gang discusses the use of Wolbachia to control mosquito-borne infections.
Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.
Alan and Rich tackle the discovery of bacteriophages, and treating influenza by calming the cytokine storm.
Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.
Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.
Vincent, Rich, and Alan discuss a method for identifying viruses of individual environmental bacteria, and the using a picornavirus for oncotherapy.
Matt Evans joins Vincent, Dickson, Alan, and Rich to deconstruct a mouse model for hepatitis C virus infection.
Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.
Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees.
Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.
The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.
Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer.
Vincent and guests Rachel Katzenellenbogen, Roger Hendrix, and Harmit Malik recorded TWiV #135 live at the 2011 ASM General Meeting in New Orleans, where they discussed transformation and oncogenesis by human papillomaviruses, the amazing collection of bacteriophages on the planet, and the evolution of genetic conflict between virus and host.
Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.
Vincent, Rich, Alan, and Dickson speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about viral infections encountered in the emergency room.
Vincent, Alan, and Dickson chat with Brad Thompson, CEO of Oncolytics Biotech, about using reovirus to treat cancer.
Vincent, Alan, and Rich discuss growth in culture of newly identified rhinovirus C, vaccinia transmission among wrestlers and martial artists, and results of phase III clinical trial of boceprevir, a new inhibitor of hepatitis C virus replication.
Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus.
Vincent, Alan, Dickson and Welkin review how a virus regulates the severity of mucocutaneous leishmaniasis, virophage control of antarctic algal host-virus dynamics, and human metapneumovirus infection in gorillas.
Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies.
Virologist Michelle Ozbun and the TWiV team review the biology of human papillomaviruses.
This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus.
Vincent, Dickson, Alan, Rich, and Grant discuss a tanapoxvirus protein that inhibits tumor necrosis factor, purging tumors with myxoma virus, and destruction of the last known stocks of smallpox virus.
Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes.
The complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, infection of monkeys with simian immunodeficiency virus, and its restriction by the cellular protein TRIM5.
A conversation about careers in virology, systems biology, innate immunity, and antiviral research recorded at the University of Washington in Seattle.
Hosts: Vincent Racaniello, Rich Condit, and Ed Niles
Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development in the biodefense world and at BARDA, and career opportunities for scientists in government.
Become a patron of TWiV!
Links for this episode: * ACAM2000smallpox vaccine * Bavarian Nordic's smallpox vaccine Imvamuneand phase II trial * Rich and Ed's paper on bacteriophage T7 mRNAs * Quandaries of dengue vaccine development * Tetravalent dengue vaccine * VIVA- virology at Vassar * TWiV on Facebook * Letters readon TWiV 120
Weekly Science Picks Rich - Dark Sun: The Making of the Hydrogen Bombby Richard Rhodes Ed - Tenth anniversary of the human genome at Science MagazineVincent - Poliovirus fights back
Send your virology questions and comments to twiv@microbe.tv.
Vincent and journalist David Tuller converse about the state of science reporting by the press.
Vincent, Alan, and Rich answer listener questions about vaccinia virus, fungal viruses, synthetic viruses, influenza vaccine, HeLa cells, multiplicity of infection, and much more.
Vincent and Rich converse with Seth Mnookin, author of The Panic Virus, about vaccines, autism, thimerosal, and a contagion of human unreason run wild.
Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens.
Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and express in a cell, and controlling viral replication inAedes aegypti with a Wolbachia symbiont.
Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute.
Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes.
The TWiV crew meets with members of the Florida Keys Mosquito Control District at Florida Gulf Coast University to discuss dengue in Florida and how to control it.
Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure.
Vincent visits Mexico City and speaks with Rosa Maria del Angel and Ana Lorena Gutiérrez about virology in Mexico, and their work on dengue and caliciviruses.
Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA.
Vincent, Dickson, Alan, and Rich answer listener questions about poliovirus, social media, dengue, influenza, evolution, gel filtration, and much more.
Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information.
Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, and identification of the cell receptor for an extinct retrovirus.
The entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, and resurgence of monkeypox in Africa.
Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association.
A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.
Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity.
Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.
On episode #99 of the podcast This Week in Virology, Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, and Myra McClure.
Host links Vincent Racaniello
Links for this episode: * 50th ICAAC * ICAAC daily press conference videos (including Prof. Myra McClure) * Antigenic cartography * Antimicrobial properties of copper
On episode #98 of the podcast This Week in Virology, Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, laboratory inventories for wild poliovirus containment, weaving high-performance viral batteries into fabric for the military, and a case of human rabies in Indiana.
On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.
On episode #96 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information.
On episode #95 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode: * WHO declares end of influenza H1N1 pandemic * CDC's FluView * WHO global monitoring of influenza * Locally acquired dengue in Key West, Florida (MMWR) * CDC page on dengue * Vaccinia virus infection in monkeys of the Brazilian Amazon * Dam site where animals were collected for vaccinia study (Google maps) * Rich's article: Whence feral vaccinia? * Viruses in the faecal microbiota of monozygotic twins and their Mothers (Nature) * New Yorker article The Treatment (thanks, Jim!) * Letters read on TWiV 95
Weekly science picks:
Alan - Families Fighting Flu Rich - Food, Inc.
Dickson - Fuel
Vincent - MIT Open Courseware
Michael - Waiting for Superman and Can Science Feed the World? (Nature)
On episode #94 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh
Links for this episode: * CFIDS Association of America * Discovery of XMRV (PLoS Pathogens) * Detection of XMRV in CFS patients (Science) * Presence of XMRV in malignant prostate (PNAS) * Inhibition of XMRV by raltegravir (PLoS One) * Letters read on TWiV 94
Weekly science picks: Alan - The new Federal Register site (see also regulations.gov) Rich - The Florida Museum of Nautural History Butterfly RainforestVincent - JoVE, the Journal of Visualized Experiments
On episode #93 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, mimivirus, splitting water with viruses, and the polio outbreak in Tajikistan.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode: * Biomedical Advanced Research and Development Authority (BARDA) * SIGA responds to BARDA request for smallpox antiviral * BARDA contract for filovirus vaccine * What is a Ph.D? (pdf) * HHMI resources for early career scientists * Pace article on abandoning prokaryote (Nature) * Three domains of life (Forterre article) * Mechanoenzymatic cleavage of Von Willebrand's factor (Science) * Splitting water with viruses * WHO coverage on Tajikstan polio outbreak * Wild type polio infection in immunized Indian children (JID) * Letters read on TWiV 93
Weekly science picks: Alan - Southern Fried Science Rich - Tree of Life web projectVincent - Dickson Despommier at Big Think
Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Bozeman, where they discussed plant viruses and how they make plants resistant to adverse conditions, and identification of dominant negative drug targets.
Host links Vincent Racaniello, Rich Condit, Karla Kirkegaard, and Marilyn Roosinck
Links for this episode: * Lifestyles of plant viruses * Using pyrosequencing to understand virus ecology * A virus in a fungus in a plant * Trans-dominant inhibition of RNA viral replication * Resistance is futile * Announcement of TWiV at ASV (pdf) * Photographs of TWiV at ASV * Letters read on TWiV 92
Weekly science picks: Marilyn - Viruses in the faecal microbiota of monozygotic twins and their mothers (Nature) Rich - The Known Universe by the American Museum of Natural HistoryVincent - The Red Queen by Matt Ridley (thanks, Jesper!)
On episode #91 of the podcast This Week in Virology, Vincent, Dickson, Alan, Rich and Welkin discuss the nature, origin, and evolution of endogenous retroviruses (ERVs), and the recent finding of endogenous filovirus genomes in mammals.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson
Links for this episode: * Welkin blogs at Small Things Considered * Constructing primate phylogenies from ancient retrovirus sequences (PNAS) * Filoviruses are ancient and integrated into mammalian genomes (BMC Evol Biol) * Synthetic cells: Momentous breakthrough or ethical morass? (To The Point) * Creation of a bacterial cell (Science) * Comments on the synthetic cell (Small Things Considered) * TWiV rap: T-Number Index by G-Unit (mp3) and Vincent (mp3) (thanks, Darrick and Scott!) * Letters read on TWiV 91
Weekly science picks:
Welkin - Advice for a Young Investigator by Santiago Ramon y Cajal
Rich - How microbes define and defend us Dickson - H1N1 virus lacks 1918 virus killer protein
Alan - The Xtal Set Society
Vincent - Antibodies and the quest for an AIDS vaccine
On episode #90 of the podcast This Week in Virology, Vincent, Alan, Rich and Eric discuss identification of viruses in Northeastern American bats, vaccinia virus infection after sexual contact with a military vaccinee, and identification of a new flavivirus from an Old World bat in Bangladesh.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Eric F. Donaldson
Links for this episode: * Vaccinia virus infection after sexual contact with vaccinee * Smallpox vaccination overview * Smallpox vaccine lesions (jpg) * Smallpox hospital, Roosevelt Island, NY (photo 1, photo 2) * Isolation of a flavivirus from bats in Bangladesh (PLoS Pathogens) * Review on hepatitis G virus * Dickson has been teaching at Singularity University and fishing in Bozeman MT (jpg) * Letters read on TWiV 90
Weekly science picks:
Eric - Year of Darwin by Sean Carroll
Rich - March of the Penguins
Alan - Standing-height desks
Vincent - DengueWatch (thanks Richard!)
On episode #89 of the podcast This Week in Virology, Vincent and Alan review recent findings on the association of the retrovirus XMRV with ME/CFS, reassortment of 2009 pandemic H1N1 influenza virus in swine, and where influenza viruses travel in the off-season.
Host links Vincent Racaniello and Alan Dove
Links for this episode: * Conflicting XMRV papers on hold * Leak of PNAS paper * CDC study on XMRV in CFS patients (Retrovirology) and Science update * Where influenza viruses travel in the off season (EurekaAlert! and PLoS Pathogens) * NPR article on Ebola siRNA treatment (thanks, Andreas!) * Priming mechanism for reovirus entry (thanks, Agyeman-Badu!) * Wired article on science PR (thanks, Dan!) * Letters read on TWiV 89
Weekly science picks:
Alan - Tree of Life graphic
Vincent - TEDx Oil Spill
On episode #88 of the podcast This Week in Virology, Vincent, Alan, and Marc discuss using a virus for beetle control, RNA based gene therapy for AIDS, and reconstitution of a endogenous human retrovirus.
Host links Vincent Racaniello, Alan Dove, and Marc Pelletier
Links for this episode: * Controlling the palm rhinoceros beetle with a virus * The virologist in the Hawaiian shirt * Information on Orcytes rhinocerus nudivirus (one, two, three) * RNA based gene therapy for AIDS * Reconstitution of an infectious human retrovirus (PLoS Pathogens) * Letters read on TWiV 88
Weekly science picks:
Marc - Apple iPad as a tool for writing, with Papers, Pages, and GoodReader
Alan - The Bacterium and the Bacteriophage
Vincent - Naturally Obsessed (thanks, Sharon!)
On episode #87 of the podcast This Week in Virology, Vincent, Alan, and Rich hear from Professor Graham Hatfull how students in the Phage Hunters Integrating Research and Education (PHIRE) program learn about scientific inquiry by doing research on bacteriophages.
Host links Vincent Racaniello, Rich Condit, Alan Dove, and Graham Hatfull
Links for this episode: * Bacteriophage Research: Gateway to learning science * Mycobacterium smegmatis at NCBI * Prof. Steve Cresawn * Scientist infected with computer virus (thanks, Jason!) * The Invisible ABCs * Letters read on TWiV 87
Weekly science picks:
Rich - CDC Public Health Image LibraryVincent - March of the Microbes by John L. Ingraham
Alan – Great Microbiologists – A Lego MovieGraham – Coral Reefs in the Microbial Seas by Forest Rohwer
On episode #86 of the podcast This Week in Virology, Vincent and Rich travel to the Blood Systems Research Institute in San Francisco to speak with Eric Delwart about his work on virus discovery.
Host links Vincent Racaniello, Rich Condit, and Eric Delwart
Links for this episode: * List of Dr. Delwart's open-access journal articles (pdf) - to find each one, type PMID # into PubMed * CDC says don't give rotavirus vaccines to infants with SCID * The Brighton Collaboration * Product sheet for RotaTeq (pdf - thanks, Sheldon!) * Letters read on TWiV 86
Weekly science picks:
Rich - Google Crisis Response - Gulf of Mexico Oil Spill
Vincent - HHMI resources for teachers and students (thanks, Jim!)
Eric - Vaccine by Arthur Allen
On episode #85 of the podcast This Week in Virology, Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses.
Host links Vincent Racaniello and Michael Gale
Links for this episode: * The Gale Laboratory at the University of Washington * Incredible view from the Gale laboratory (jpg) * Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses (review) * New potent HCV inhibitor * HCV virion and genome structures at ViralZone
On episode #84 of the podcast This Week in Virology, Vincent and Rich spoke with Dave Bloom and Grant McFadden about their work on herpesviruses and poxviruses in this episode recorded before an audience at the University of Florida, Gainesville - home of the Gators.
Host links Vincent Racaniello, Rich Condit, Dave Bloom, and Grant McFadden
Links for this episode: * Epigenetic modulation of herpes simplex virus gene expression (thanks, Matthew!) * The Red Queen and Tierra virtual environment: article one, two, three (thanks, Jesper!) * Hand-held HIV detector (thanks, Jim!) * Anti-angiogenic cancer therapy combined with oncolytic virotherapy (thanks, Bill!) * TWiV at UF Gainesville (jpg) * Letters read on TWiV 84
Weekly science picks:
Rich - Charles F. Littlewood photographs
Vincent - Not so humble pie (thanks, Sophie!)
Grant - The Strangest Man by Graham Farmelo
David - Is Parkinson's Disease a prion disorder?
On episode #83 of the podcast This Week in Virology, Vincent, Alan, Rich, and special guest Dr. Kirsten Sanford talk about her career in science media, then consider whether smallpox eradication led to the AIDS pandemic, high fidelity RNA synthesis, and a new Ebola virus vaccine.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Kirsten Sanford
Links for this episode: * Does smallpox vaccine protect against HIV? (thanks, Srinivas; Washington Post and BMC Immunology) * Was the deltaCRR5 mutation fixed in the human population by smallpox? * A proofreader in the SARS coronavirus genome * New ebola vaccine protects monkeys * House of Numbers trailer, website, Wikipedia article (thanks, Levi!) * Letters read on TWiV 83
Weekly science picks:
Alan - Evernote
Rich - The Knife Man by Wendy Moore
Vincent - The Pump Handle
On episode #82 of the podcast This Week in Virology, Vincent and Rich talk about how thymic selection of T cells might lead to better control of HIV-1 infection, and a mouse model for severe antibody-induced dengue virus disease.
Host links Vincent Racaniello and Rich Condit
Links for this episode: * Effect of thymic selection of T-cells on control of AIDS * Mouse model of antibody-induced severe dengue virus disease * Natural antibody protects against viral infection * Kary Mullis idea for fighting infections (thanks, Erik!) * 40 nm resolution of fluorescence photoactivation localization microscopy (thanks, José) * Letters read on TWiV 82
Weekly science picks:
Rich The Mold in Dr. Florey's Coat: The Story of the Penicillin Miracle by Eric Lax
Vincent Proteopedia (thanks, Erik!)
On episode #81 of the podcast This Week in Virology, Vincent and Rich answer listener questions on viruses and gluten allergy, RNA silencing, influenza virus, herpes simplex virus, HIV/AIDS, chronic fatigue syndrome, manicure salons, and the koala tea of Marseilles.
Host links Vincent Racaniello and Rich Condit
Links for this episode: * Virus infections and gluten intolerance on TWiS (thanks Jesper!) * Viral small RNAs in PLoS Pathogens (thanks Jason!) * Canadian Summit Awards (thanks Jim!) * Experimenting with phage at home (thanks Richard!) * CRISPR discovered by a dairy company (thanks Joel!) * Expedition to New Guinea to sample bird viruses - movie and blog entry (thanks Henrik!) * Preventing herpes with arginine and lysine - pdf (thanks Anthony!) * Chronic fatigue donors face rejection (thanks James!) * The Koala tea of Marseilles is not strained (thanks Stephen!) * The other Larson virus cartoon (jpg) * Letters read on TWiV 81
Weekly science picks:
Rich Google Chrome browser 'speed test' (and how it was made)
Vincent Inside the Outbreaks by Mark Pendergrast
On episode #80 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Michael Bouchard about hepatitis B virus discovery, replication, and pathogenesis.
Host links Vincent Racaniello, Alan Dove, Rich Condit, and Michael Bouchard
Links for this episode: * The enigmatic X gene of hepatitis B virus * Tableau public (thanks Ricardo!) * Molecular phylogeny of Archaea from soil (thanks Etienne!) * Habitats of Archaea (thanks Cedric!) * Timer remote controls (thanks Bill!) * Letters read in episode 80
Weekly science picks:
Rich PBS Frontline: The Vaccine War
Alan Readability
Vincent Starswarm by Jerry Pournelle
On episode #79 of the podcast This Week in Virology, Vincent and Alan converse about making published science accessible to everyone, global eradication of poliomyelitis, and whether a plant virus can cause disease in humans.
Host links Vincent Racaniello and Alan Dove
Links for this episode: * Making published science accessible to everyone (Nature News) * Federal Research Public Access Act * Is disease eradication a waste of money? * Do we have an ethical obligation to eradicate polio? * Signs of progress in polio eradication (NY Times) * Polio eradication: Harder than it looks (Fortner) * Gates rethinks his war on polio (WSJ) * Asymptomatic wild-type poliovirus infection in immune children (J Inf Dis) * Can a plant virus cause disease in humans? (PLoS One) * Replication of tomato spotted wilt virus in HeLa cells (PNAS) * Glycine detected in comet (thanks Vincent!) * Letters read on TWiV 79
Weekly science picks:
Alan Data.gov
Vincent foldit
On episode #78 of the podcast This Week in Virology, Vincent, Alan, Dickson, and Rich talk about treating arthritis with a tanapox virus protein, Darwinian evolution of prions in cell culture, and the connection between cold weather fronts and outbreaks of avian H5N1 influenza in Europe.
Host links Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit
Links for this episode: * Treating arthritis with a tanapox virus protein that antagonizes TNF (press release and research article) * Darwinian evolution of prions in cell culture (abstract) * Simple diagram of prion propagation (Wikipedia) * Thoughts on the pursuit of success in science by Charles Weissmann * Cold fronts linked to European H5N1 outbreaks (PLoS Pathogens) * Simon Singh's website and letter of support (thanks, Mary!) * The importance of stupidity in scientific research (thanks, Mary!) * Sustainable energy - without the hot air (thanks, Bernhard!) * World Community Grid (thanks Dave!) * Pre-order The Vertical Farm by Dickson Despommier * Letters read on TWiV 78
Weekly science picks:
Dickson Medical News Today: Infectious Diseases and Eaarth by Bill McKibben
Rich U can with Beakman and Jax by Jok Church
Alan UnderwaterTimes
Vincent The Reef Tank
On episode #77 of the podcast This Week in Virology, Vincent, Alan, and Rich revisit circovirus contamination of Rotarix, then discuss poxvirus-like replication of mimivirus in the cell cytoplasm, and whether seasonal influenza immunization increases the risk of infection with the 2009 H1N1 pandemic virus.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode: * Contamination of Rotarix vaccine with porcine circovirus 1 DNA * Do you want to know what is in your vaccines? Take the poll * Mimivirus replicates in the cell cytoplasm like poxviruses * mRNA capping and virus evolution * Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness (commentary) * Doane paper goes viral * Energetics of genome ejection from bacteriophage (thanks Gary!) * Five strategies for behavioral adaptation to pathogens and parasites (excerpt; thanks Wladimir!) * Letters read on TWiV 77
Weekly science picks:
Rich The Way We Work by David Macaulay
Alan DimDim
Vincent Polio: An American Story by David Oshinsky
On episode #76 of the podcast This Week in Virology, Vincent speaks with Stephen Goff about the origin of the retrovirus XMRV and its association with prostate cancer and chronic fatigue syndrome.
Host links Vincent Racaniello and Stephen Goff
Links for this episode: * Discovery of XMRV in prostate tumors * Association of XMRV with chronic fatigue syndrome * Enhanced infection of prostate cells by XMRV * XMRV and xenotransplantation
On episode #75 of the podcast This Week in Virology, Vincent, Alan, and Matt review contamination of Rotarix with circovirus DNA, antigenic similarity between 1918 and 2009 H1N1 influenza, a collection of rabies reports, and chicken pox mistaken for smallpox in Uganda.
Host links Vincent Racaniello, Alan Dove, and Matthew Frieman
Links for this episode: * Contamination of Rotarix vaccine with porcine circovirus 1 DNA * Beak and feather disease circovirus (BFDV) threatens parrots * Antigenic similarity between 1918 and 2009 H1N1 influenza * Presumptive abortive human rabies in Texas * Rabies rampant: feline, immunization change, Indonesia, wolf, Texas bat, US equine (thanks, Lenn!) * Austin free tailed bats emerging at dusk * Suspected smallpox in Uganda * T-cell receptor therapy for AIDS (thanks Dorian!)
Weekly science picks:
Matt Bitesize Bio
Alan Free printable graph paper (see also doane paper)Vincent Avian Flu Diary
On episode #74 of the podcast This Week in Virology, Vincent speaks with Adolfo Garcia-Sastre about the origin, pathogenesis, and prevention of the 2009 pandemic influenza H1N1 virus.
Host links Vincent Racaniello and Adolfo Garcia-Sastre
Links for this episode: * Influenza virus receptor specificity and disease * PB1-F2 expression by 2009 H1N1 strain does not increase virulence * Protection against 2009 H1N1 infection by immunization with older strains * Passage in eggs changes influenza receptor specificity * Association between D222G mutation and virulence
On episode #73 of the podcast This Week in Virology, Vincent, Dickson, and Rich discuss multipotent progenitor bone marrow cells as a reservoir of HIV-1, integration of HHV-6 into telomeres, and dispersal of West Nile virus across the US by mosquitoes.
Host links Vincent Racaniello, Dickson Despommier, and Rich Condit
Links for this episode: * HIV-1 infects multipotent progenitor cells * HHV-6 genome integrates into telomeres * A role for mosquito-mediated dispersal of West Nile virus across the US * Using tobacco mosaic virus to produce synthetic photovoltaic cells (thanks Nissin!) * Animation of HIV replication cycle (thanks Ilya!) * Can computer viruses evolve? (thanks Norman!) * Mumps outbreak in Israel (one and two) (thanks Ariel!) * Bocavirus infections in children (thanks Tyler!)
Weekly science picks:
Dickson Whole-Genome Sequencing in a Patient with Charcot–Marie–Tooth Neuropathy (NEJM and NY Times)
Rich Invisible Frontiers: The Race to Synthesize a Human Geneby Stephen Hall
Vincent Conference on Retroviruses and Opportunistic Infections - videocasts
On episode #72 of the podcast This Week in Virology, Vincent, Dickson, Alan and Rich explain CRISPR/Cas, the immune system of bacteria and archaea, how novel viruses are discovered by deep sequencing of small RNAs, and the relationship between dry weather and outbreaks of West Nile virus infection.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode: * Review on the CRISPR/cas system of bacteria and archaea * Virus discovery by sequencing small virus-derived RNAs (paper one and two) * Dry weather induces outbreaks of West Nile virus infection (paper and comment form) * Vaccine needle size matters * Participate in the Personal Genome Project
Weekly science picks:
Dickson Scientist as Chef by Dickson Despommier (pdf)
Alan Networked Organisms and Habitats (NOAH) iPhone appRich Never Cry Wolf by Farley Mowat
Vincent The Dish
On episode #71 of the podcast This Week in Virology, Vincent, Dickson, Alan and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, and junk DNA.
Host links Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit
Links for this episode: * Maternal infection and fetal neurological injury * Filtering prions from blood (prion capture technology) * Eradication of rinderpest (Merck veterinary manual) * Podcasts from Life in the Universe course * Immune Attack video game * H1N1 review article and Holmes on genetic hijacking * Podcast on Merck vaccines * Ft. Lee NJ snowed in (jpg)
Weekly science picks:
Dickson and Alan NSF/AAAS Science and Engineering Visualization ChallengeRich Foundation by Issac Asimov
Vincent Natural Obsessions by Natalie Angier
On episode #70 of the podcast This Week in Virology, Vincent, Dickson, and Alan consider a broad spectrum antiviral against enveloped viruses, how a plant virus induces chemical signals in the host to maximize its spread, a new way to preserve viral vaccines at tropical temperatures, and the continuing story of XMRV and chronic fatigue syndrome.
Host links Vincent Racaniello, Dickson Despommier, and Alan Dove
Links for this episode: * Broad spectrum antiviral against enveloped viruses * Chemical signals induced by a plant virus attract insect vectors to inferior hosts * New vaccine technology to make viral vaccines stable at tropical temperatures * Second UK study fails to find XMRV in chronic fatigue syndrome patients (pdf) * Nature podcast with Simon Singh and petition (thanks André!) * Letter on Wolbachia and bees (thanks Tom!) * Dickson fishing in Argentina (jpg)
Weekly science picks:
Dickson Chemical Ecology - edited by Thomas Eisner and Jerrold Meinwald
Alan Scripps Center for Mass Spectrometry
Vincent Folding@home (thanks Jesper!)
On episode #69 of the podcast This Week in Virology, Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 vaccines, and a virus-like particle vaccine for chikungunya virus.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode: * Mumps outbreak in Israel (ProMedMail and Eurosurveillance; thanks Lenn!) and Iowa * Retraction of Wakefield vaccines- autism study * Immunization with 1918-like and classical swine H1N1 influenza viruses protects against 2009 H1N1 strain * Virus-like particle vaccine for chikungunya virus * Image: antigenic differences in HA structures of 1918, Cal/09 and Bris/59/07 viruses * Paul Ewald articles (thanks Atila!): one, two, and three, and a recent review of the hypothesis
Weekly science picks:
Rich John Moran Florida Nature Photography
Alan Periodic Table of Videos
Vincent The Protein Databank Educational Resources
On episode #68 of the podcast This Week in Virology, Vincent, Alan, and Rich are enthralled by movies of vaccinia virus plaque formation, then consider how repulsion of superinfection virions leads to rapid virus spread, and a therapeutic prostate cancer vaccine.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode: * Rapid virus spread by repulsion of superinfection virions * Movie of vaccinia virus plaque formation (.mov) * Movie of GFP-vaccinia virus plaque formation (.mov) * More amazing vaccinia virus movies * Prostate cancer vaccine (Reuters article, original research)
Weekly science picks:
Rich Foundations of Virology - PowerPoint by Frederick A. Murphy (bio/interview pdf)
Alan Spoonful of Medicine - Nature Medicine blog
Vincent The Feynman Lectures (thanks Ilya!)
On episode #67 of the podcast This Week in Virology, Vincent, Alan, and Marc Pelletier talk about chronic wasting disease of deer caused by prions, blocking the semen-derived enhancer of HIV infection with surfen, and making green transgenic rabbits using a lentiviral vector.
Host links Vincent Racaniello, Alan Dove, and Marc Pelletier
Links for this episode: * Chronic wasting disease in West Virginia * Chronic wasting disease alliance and CDC webpage * Semen-derived inhibitor of viral infection (SEVI) * Surfen inhibits the action of SEVI * Making green transgenic rabbits using simian immunodeficiency virus vector * Science comedy (thanks Lucky Fractal!)
Weekly science picks:
Marc Association of Science-Technology Centers Passport Program
Alan Zooniverse
Vincent Grand Rounds at the Mailman School of Public Health
On episode #66 of the podcast This Week in Virology, Vincent and Dickson continue virology 101 with a discussion of information flow from RNA to DNA, a process known as reverse transcription, which occurs in cells infected with retroviruses, hepatitis B virus, cauliflower mosaic virus, foamy viruses, and even in uninfected cells.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode: * Discovery of RNA tumor viruses * Reverse transcriptase found by Temin and Baltimore (pdfs) * Figures for this episode
On episode #65 of the podcast This Week in Virology, Vincent, Alan, and Matthew Frieman Vincent, Alan, and Matt discuss a project to study the RNA virome of Northeastern American bats, failure to detect XMRV in UK chronic fatigue syndrome patients, and DNA of bornavirus, an RNA virus, in mammalian genomes.
Host links Vincent Racaniello, Alan Dove, and Matthew Frieman
Links for this episode: * Mist net Indigo Tunnel, Western Maryland Railway (jpg) * Eric Donaldson and Amy Haskew with bat in holding bag (jpg) * XMRV not detected in UK chronic fatigue syndrome patients (virology blog) * Bornavirus DNA in the mammalian genome * Arenavirus DNA can be integrated into the cell genome * Rabid raccoons in Central Park, NYC
On episode #64 of the podcast This Week in Virology, Vincent, Alan, and Rich discuss ten compelling virology stories of 2009.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Ten virology stories of 2009: 1. Pandemic influenza: Swine-origin H1N1 virus (TWiV 36) 2. XMRV, prostate cancer, and chronic fatigue syndrome (TWiV 50, 55) 3. AIDS vaccine 'success' (TWiV 51) 4. Colony collapse disorder (TWiV 46, 49) 5. AIDS-like disease in wild chimps (TWiV 45) 6. Diverse viral community in Antarctic lake (TWiV 58) 7. Polyomavirus seroepidemiology in humans (TWiV 26) 8. Poxvirus threatens UK red squirrels (TWiV 63) 9. Polio spreads from Nigeria (TWiV 29) 10. How mosquitoes survive Dengue virus infection (TWiV 21)
Picture book on viruses for kids (Thanks Soraia!)
On episode #63 of the podcast This Week in Virology, Vincent, Alan, and Rich talk about US government contract for freeze-dried smallpox vaccine, red squirrels in the UK threatened by poxvirus, and Marseillevirus, another DNA virus from amoebae built for comfort and speed.
Host links Vincent Racaniello, Alan Dove, and Rich Condit
Links for this episode: * US Government awards contract to Bavarian Nordic for freeze-dried smallpox vaccine (pdf and clinical trial) * UK red squirrels threatened by poxvirus: news article one and two,epidemiologyand experimental infection * Another huge virus from amoebae (Wired article, PNASarticle, review article) * Discussion on rabies bait vaccine at virology blog, and status of the program * Viral diseases of humans (pdf)
On episode #62 of the podcast This Week in Virology, Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.
Host links Vincent Racaniello, Dickson Despommier, and Alan Dove
Links for this episode:
- HIV vaccine failure probably caused by adenovirus vector used
- Persistence of West Nile virus in kidneys for years (JID and ProMedMail) (thanks, Lenn!)
- Adaptive strategies of influenza RNA polymerase for replication in humans
- New CDC estimates of 2009 H1N1 infection in US
- Receptor binding specificity of 2009 H1N1 virus
- Distribution of sialic acids in human respiratory tract
On episode #62 of the podcast This Week in Virology, Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.
Host links Vincent Racaniello, Dickson Despommier, and Alan Dove
*Links for this episode:*
- HIV vaccine failure probably caused by adenovirus vector used
- Persistence of West Nile virus in kidneys for years (JID and ProMedMail) (thanks, Lenn!)
- Adaptive strategies of influenza RNA polymerase for replication in humans
- New CDC estimates of 2009 H1N1 infection in US
- Receptor binding specificity of 2009 H1N1 virus
- Distribution of sialic acids in human respiratory tract
On episode 61 of the podcast "This Week in Virology", Vincent and Dick muse about the symbiotic bacterium,Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.
Host links Vincent Racaniello and Dickson Despommier
*Links for this episode:*
- Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans
- Wolbachia induces resistance to RNA virus infections in Drosophila
- Wolbachia reduces blood-feeding success in Dengue mosquito
- Did 2009 H1N1 influenza come from a laboratory?
- Influenza original antigenic sin in mice but not in humans
- Dengue outbreak in Mexico (thanks Swiss compass!)
- Pig at Minnesota state fair infected with 2009 H1N1 (thanks Swiss compass!)
- Baby kissing pig (jpg) (thanks Swiss compass!)
On episode 61 of the podcast "This Week in Virology", Vincent and Dick muse about the symbiotic bacterium,Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode:
- Variation in antiviral protection mediated by different Wolbachia strains in Drosophila simulans
- Wolbachia induces resistance to RNA virus infections in Drosophila
- Wolbachia reduces blood-feeding success in Dengue mosquito
- Did 2009 H1N1 influenza come from a laboratory?
- Influenza original antigenic sin in mice but not in humans
- Dengue outbreak in Mexico (thanks Swiss compass!)
- Pig at Minnesota state fair infected with 2009 H1N1 (thanks Swiss compass!)
- Baby kissing pig (jpg) (thanks Swiss compass!)
Vincent and Dickson continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.
Host links Vincent Racaniello and Dickson Despommier
Links for this episode: * Diagrams of viral RNA synthesis * Animations of influenza virus and HIV-1 replication
Vincent and Dickson continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.
Host links Vincent Racaniello and Dickson Despommier
*Links for this episode:* * Diagrams of viral RNA synthesis * Animations of influenza virus and HIV-1 replication
A TWiV panel of five considers the finding of Streptococcus pneumoniae in fatal H1N1 cases in Argentina, hysteria in the Ukraine over pandemic influenza, and human vaccinia infection after contact with a raccoon rabies vaccine bait.
*Host links* Vincent Racaniello, Alan Dove, Rich Condit, Gustavo Palacios, and Mady Hornig
Links for this episode:
- Argentine flu death mystery
- H1N1 influenza outbreak in Ukraine (article one and two, and WHO statement)
- Human vaccinia infection after contact with rabies vaccine bait
- Agrippal S1 inactivated H1N1 vaccine (pdf - thanks Ariel and Ayelet)
- Nick's letter on are viruses and life
- Take the poll: are viruses alive?
A TWiV panel of five considers the finding of Streptococcus pneumoniae in fatal H1N1 cases in Argentina, hysteria in the Ukraine over pandemic influenza, and human vaccinia infection after contact with a raccoon rabies vaccine bait.
Host links Vincent Racaniello, Alan Dove, Rich Condit, Gustavo Palacios, and Mady Hornig
Links for this episode:
- Argentine flu death mystery
- H1N1 influenza outbreak in Ukraine (article one and two, and WHO statement)
- Human vaccinia infection after contact with rabies vaccine bait
- Agrippal S1 inactivated H1N1 vaccine (pdf - thanks Ariel and Ayelet)
- Nick's letter on are viruses and life
- Take the poll: are viruses alive?
Vincent, Dick, and Alan are joined by emergency medicine physician Dr. Joshua Stillman to talk about passive antibody therapy for Nipah infection in ferrets, annual influenza immunization of children, facemasks to prevent influenza, predicting dengue outbreaks by the weather, and the amazing viral communities in an icy Antarctic lake.
Host links Vincent Racaniello, Dick Despommier, Alan Dove, and Joshua Stillman
Links for this episode:
- Post-exposure passive antibody therapy for Nipah virus in ferret
- Image above left shows Nipah viral antigen (red) in ferret brain ependymal epithelium
- Is yearly influenza vaccination of children a bad idea?
- Debate on N95 masks vs surgical masks to prevent influenza
- Weather patterns help predict dengue outbreaks
- Diverse viral community in Antarctica's icy lakes (thanks Russ!)
- Tamiflu in Japanese river waters (see TWiV 40 - thanks Russ!)
- Chlorine dioxide gas removes influenza virus (thanks André!)
Vincent, Dick, and Alan are joined by emergency medicine physician Dr. Joshua Stillman to talk about passive antibody therapy for Nipah infection in ferrets, annual influenza immunization of children, facemasks to prevent influenza, predicting dengue outbreaks by the weather, and the amazing viral communities in an icy Antarctic lake.
Host links Vincent Racaniello, Dick Despommier, Alan Dove, and Joshua Stillman
Links for this episode:
- Post-exposure passive antibody therapy for Nipah virus in ferret
- Image above left shows Nipah viral antigen (red) in ferret brain ependymal epithelium
- Is yearly influenza vaccination of children a bad idea?
- Debate on N95 masks vs surgical masks to prevent influenza
- Weather patterns help predict dengue outbreaks
- Diverse viral community in Antarctica's icy lakes (thanks Russ!)
- Tamiflu in Japanese river waters (see TWiV 40 - thanks Russ!)
- Chlorine dioxide gas removes influenza virus (thanks André!)
Vincent visits Scotch Plains – Fanwood High School and talks about viruses with high school biology students.
Host links: Vincent Racaniello
Links for this episode:
- Vincent’s presentation (pdf)
- Thank you letters
- Oncolytic reovirus
- Does rhinovirus interfere with influenza?
Vincent visits Scotch Plains – Fanwood High School and talks about viruses with high school biology students.
Host links: Vincent Racaniello
Links for this episode:
- Vincent’s presentation (pdf)
- Thank you letters
- Oncolytic reovirus
- Does rhinovirus interfere with influenza?
Vincent, Dick, Alan, and Cliff answer questions from listeners on swine influenza origins, transmission, virulence, and vaccines, HIV and AIDS, and more.
Host links: Vincent Racaniello, Dick Despommier, Alan Dove, and Cliff Mintz
Links for this episode:
- Physicists propose 'Schrödinger's Virus' experiment (thanks Duncan)
- Nanoparticle adjuvant (ScienceDaily and Journal of Controlled Release - thanks Jim)
- Hand washing won't stop H1N1 at Newsweek (thanks Jim)
- Newsweek's virus quiz
- TWiV timeline (download .m4v file - thanks Ricardo)
- Sanjay Gupta's H1N1 experience (thanks Lenn)
- Swine flu vaccine fear mongering at eSkeptic (thanks Jesper)
- Flu transmission and humidity (letter from Joe)
Weekly Science Picks
Dick 27" iMac and Powers of Ten by Philip Morrison and Phyllis Morrison
*Alan ImageMagick
Cliff *ePatient Connections 2009
Vincent**** Cell size and scale
Vincent, Dick, Alan, and Cliff answer questions from listeners on swine influenza origins, transmission, virulence, and vaccines, HIV and AIDS, and more.
Host links: Vincent Racaniello, Dick Despommier, Alan Dove, and Cliff Mintz
Links for this episode:
- Physicists propose 'Schrödinger's Virus' experiment (thanks Duncan)
- Nanoparticle adjuvant (ScienceDaily and Journal of Controlled Release - thanks Jim)
- Hand washing won't stop H1N1 at Newsweek (thanks Jim)
- Newsweek's virus quiz
- TWiV timeline (download .m4v file - thanks Ricardo)
- Sanjay Gupta's H1N1 experience (thanks Lenn)
- Swine flu vaccine fear mongering at eSkeptic (thanks Jesper)
- Flu transmission and humidity (letter from Joe)
Weekly Science Picks Dick 27" iMac and Powers of Ten by Philip Morrison and Phyllis MorrisonAlan ImageMagickCliff ePatient Connections 2009Vincent Cell size and scale
The largest TWiV panel ever assembled takes on XMRV and chronic fatigue syndrome, 2009 chemistry Nobel prizes for ribosome structure, finding new poxvirus vaccine candidates, a brouhaha over leaked Canadian data on flu susceptibility, and transmission of H1N1 influenza to a pet ferret.
Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, Jason Rodriguez, and Rich Condit
Links for this episode: * XMRV and chronic fatigue syndrome * XMRV not found in German prostate cancer * 2009 Chemistry Nobel Prize for ribosome structure * New poxvirus vaccines (e! Science and Virology articles - thanks Jim!) * Seasonal flu shots and susceptibility to 2009 H1N1 (one, two, and three) * Pet ferret gets H1N1 influenza from owner
Weekly Science Picks Dick Nikon photomicroscopy contest winners at SciAm (Dick's article on vertical farming)Alan Make:Rich BBC's Planet Earth (DVD at Amazon)Jason The Collider, the Particle and a Theory About FateVincent An Epidemic of Fear and Misinformants at Wired Magazine
The largest TWiV panel ever assembled takes on XMRV and chronic fatigue syndrome, 2009 chemistry Nobel prizes for ribosome structure, finding new poxvirus vaccine candidates, a brouhaha over leaked Canadian data on flu susceptibility, and transmission of H1N1 influenza to a pet ferret.
Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, Jason Rodriguez, and Rich Condit
Links for this episode: * XMRV and chronic fatigue syndrome * XMRV not found in German prostate cancer * 2009 Chemistry Nobel Prize for ribosome structure * New poxvirus vaccines (e! Science and Virology articles - thanks Jim!) * Seasonal flu shots and susceptibility to 2009 H1N1 (one, two, and three) * Pet ferret gets H1N1 influenza from owner
Weekly Science Picks
Dick Nikon photomicroscopy contest winners at SciAm (Dick's article on vertical farming)
*Alan* Make:
Rich BBC's Planet Earth (DVD at Amazon)
Jason The Collider, the Particle and a Theory About Fate
*Vincent An Epidemic of Fear and Misinformants* at Wired Magazine
Vincent speaks with Lynn Enquist about his career in virology, moving from academia to industry and back. Along the way he did pioneering research on bacteriophage, participated in the birth of recombinant DNA technology, and studied herpesviruses.
Links for this episode:
- Holliday junction
- Asilomar Conference on Recombinant DNA
- Restriction enzymes
- Movies of herpesvirus movement in nerve cells
- The 'other' Enquist lab
- Can you find the TWiV 54 hosts in this photo?
Weekly Science Picks
Lynn Francis Crick: Hunter of Life's Secrets by Robert Olby
Vincent ViralZone
Vincent speaks with Lynn Enquist about his career in virology, moving from academia to industry and back. Along the way he did pioneering research on bacteriophage, participated in the birth of recombinant DNA technology, and studied herpesviruses.
Links for this episode:
- Holliday junction
- Asilomar Conference on Recombinant DNA
- Restriction enzymes
- Movies of herpesvirus movement in nerve cells
- The 'other' Enquist lab
- Can you find the TWiV 54 hosts in this photo?
Weekly Science Picks Lynn Francis Crick: Hunter of Life's Secrets by Robert OlbyVincent ViralZone
Vincent, Dick, and Alan talk about Nobel prizes for telomere research, bacteriophages that protect aphids from wasps, salicylates and pandemic influenza mortality, and hand washing.
Links for this episode: * Bacteriophages encode toxins that protect aphids from wasps * 14 year old dies after receiving HPV vaccine * Salicylates and pandemic influenza mortality * Canadian microbiologist says hand washing is not proven to prevent influenza * Surgical mask vs N95 respirator for preventing influenza * Americans unsure about receiving pandemic H1N1 influenza vaccine * DnaTube (thanks Jim!) * Laboratory Director certification (pdf - thanks Megan!) * Plant production of pharmaceuticals (pdf one and pdf two - thanks Ed!)
Weekly Science Picks Alan sciencelineDick Younger by Judith Sulzberger MDVincent FluView
Vincent, Dick, and Alan talk about Nobel prizes for telomere research, bacteriophages that protect aphids from wasps, salicylates and pandemic influenza mortality, and hand washing.
Links for this episode: * Bacteriophages encode toxins that protect aphids from wasps * 14 year old dies after receiving HPV vaccine * Salicylates and pandemic influenza mortality * Canadian microbiologist says hand washing is not proven to prevent influenza * Surgical mask vs N95 respirator for preventing influenza * Americans unsure about receiving pandemic H1N1 influenza vaccine * DnaTube (thanks Jim!) * Laboratory Director certification (pdf - thanks Megan!) * Plant production of pharmaceuticals (pdf one and pdf two - thanks Ed!)
Weekly Science Picks
Alan scienceline
Dick Younger by Judith Sulzberger MD
Vincent FluView
Vincent and Dr. Scott Hammer talk about different types of AIDS vaccines and how they are tested in clinical trials.
Links for this episode: * PAVE 100 trial cancelled * HIV vaccine shows promise for the first time * Description of the Thailand AIDS program * NEJM review on why AIDS vaccine is difficult (pdf) * Arguments for the AIDS vaccine trial in Thailand * International AIDS Vaccine Initiative (IAVI)
Vincent, Dick, and Alan (with a cameo appearance by Rich Condit) review the world’s largest Phase III study of a complex HIV vaccine candidate in Thailand, immunization of salmon against infectious salmon anemia virus, and an outbreak of blueberry shock virus in Michigan.
Links for this episode: * HIV vaccine shows promise for the first time - description of the program, FDA background document (pdf), NEJM review on why AIDS vaccine is difficult (pdf), and arguments for the trial * Chile immunizes salmon (USGS article on the virus, pdf) * Blueberry virus strikes Michigan research center (information on the disease and the virus) * Rotavirus seasonality (thanks Didier!) * Viruses and the tree of life at virology blog * Big brains have evolved twice (thanks Arsen!)
Weekly Science Picks
Alan Bat Rabies and Other Lyssavirus Infections
Dick Boosting Vaccines: The Power of Adjuvants *(Scientific American; subscription required)
Vincent *The Ig Nobel Prizes by Marc Abrahams
Vincent and Jason review influenza 2009 H1N1 vaccine trials and protection against the virus conferred by the 1976 swine flu vaccine, then move on to a virus called XMRV and its possible role in prostate cancer.
Links for this episode: * One dose of influenza 2009 H1N1 vaccine without adjuvant is enough * Partially completed study on influenza 2009 H1N1 vaccine with MF59 adjuvant * 1976 swine flu vaccine induces cross-reactive antibodies against influenza 2009 H1N1 strain * Explanation of hemagglutination-inhibition and microneutralization assays * FDA approves influenza 2009 H1N1 vaccine * XMRV is present in malignant prostatic epithelium and is associated with prostate cancer * Identification of a novel gammaretrovirus in prostate tumors * CDC page on Guillain-Barré syndrome
Weekly Science Picks
Jason Glass Microbiology
Vincent FluWeb Influenza Historical Resources Database
Vincent and Dick continue Virology 101 with a discussion of the seven different types of viral genomes, and how to use the pathway to mRNA to understand viral replication.
Links for this episode:
- Dick talks about hookworm on Radio Lab
- Dick's video page at BigThink
- The seven types of viral genome
- Animation of HIV replication (thanks axiomatically atypical!)
- Changes in transcript abundance relating to colony collapse disorder in honey bee (thanks Judi!)
Weekly Science Picks Dick Discovery Channel: Planet Green*Vincent* Influenza videos at BigThink: one, two, three, four, five, six
Vincent, Dick, Alan and Rich revisit a vaccinia virus lab accident and viral vaccines produced in plants, then talk about an iPhone app to track infectious diseases, flying foxes, and an inhaled measles vaccine.
Links for this episode: * Laboratory acquired vaccinia infection * Medicago (investor presentation, pdf) and Fraunhofer produce vaccines in plants * iPhone app Outbreaks near me * No culling of flying foxes in Australia * Inhaled powdered measles virus vaccine * Herpesvirus latency confers symbiotic protection from bacterial infection (thanks Juliet!) * Porcine circovirus vaccine * Swine flu vaccine and Guillain-Barré (thanks Tom!) * The Great Flu and blog post (thanks Swiss compass and Allison!) * Building semiconductors with DNA (thanks Duncan!) * Email on viral classification (thanks Rodney and Eliot!)
Weekly Science Picks
*RichStumbling on Happiness by Daniel Gilbert
DickEliot Porter at the Carter Museum and bookstore at Amazon
AlanDr. Clarke's H1N1 rap at the HHS sponsored YouTube contest
Vincent***Coast to Coast Bio Podcast
Vincent and Dick discuss influenza virus-like particle vaccines produced in insect and plant cells, rapid sharing of influenza research, and answer listener questions about cytomegalovirus, viral evolution and symbiosis and much more.
Links for this episode: * A Farm on Every Floor * Influenza virus-like particles in insect and plant cells * PLoS Currents: Influenza * Transmission of 2009 H1N1 influenza virus to turkeys [Thanks Debbie!] * Baxter produces Vero cell H1N1 vaccine [Thanks Peter!] * Boundaries of Darwinism podcast [Thanks David!] * Phages in human intestine: papers one, two, three [Thanks Terry!] * Post-exposure varicella vaccine [Thanks Patricia!] * Open science movement here, here, here, and here [Thanks Jim!] * Graduate programs in virology [Thanks Greggory and Blake!] * Post-exposure Marburg and Ebola vaccines [Thanks John!] * Vaccinia infection in the laboratory [Thanks Russ!] * Animations of bacteriophage T4 life cycle [Thanks Jim!]
Weekly Science Picks
Vincent Bionumbers
Dick Ocean: An Illustrated Atlas by Sylvia A. Earle, Linda K. Glover
Vincent and Dick continue virology 101 with a discussion of virus entry into cells, then answer reader email on colony collapse disorder and viruses that confer a benefit to their host.
Links for this episode: * Illustrations of virus entry into cells * Nice reference for biological items (thanks Jim!) * Colony collapse disorder: PBS program, descriptive study, metagenomic study, genetic analysis (thanks Swiss compass!) * Potato virus Y and Alzheimer's disease (thanks Jennifer!) * A virus in a fungus in a plant (thanks Jennifer!)
Weekly Science Picks
Vincent PLoS Pearls
Dick West Nile virus website at CDC
Vincent, Dick, Alan, and Jennifer Drahos tackle the Hendra virus disease outbreak in Australia, AIDS-like disease in wild chimps, return of polio type 2 in Nigeria, the influenza pandemic wave, and rabies in three countries.
Links for this episode: * Hendra virus killing horses in Australia * AIDS-like disease in wild chimps [ NY Times ] * Polio type 2 returns in Nigeria * Influenza pandemic wave [Branswell ] * Rabies in Ukraine , South Africa , and USA * Cell phones turned into fluorescent microscopes [Thanks, Jim!] * HIV-1 vaccine trial in South Africa [Thanks Duncan!] * Forum discussion on flu vaccine [Thanks James!] * The Brain Science Podcast [Thanks Jim!] * WHO note on H1N1 vaccine safety * CDC information on H1N1 vaccines * Hans Christian Orsted
Weekly Science Picks
Jennifer Art of Science 2009
Vincent Nobel Intent
Dick Diversity of Life by EO Wilson
Alan MediaWiki (install tips )
Vincent, Dick, Alan, and Jennifer Drahos consider Marburg virus in Egyptian fruit bats, bacterial citrus pathogen found in shipping facility, canine parvovirus in Michigan, Relenza-resistant influenza virus, new HIV from gorillas, and public engagement on H1N1 immunization program.
Links for this episode: * Isolation of Marburg virus from Egyptian fruit bats * Inspectors find bacterial citrus pathogen in California * Parvovirus killing hundreds of dogs in Michigan * Relenza-resistant H1N1 identified in Australia (press and journal article) * New HIV from gorilla * CDC wants public comment on H1N1 vaccination * Original antigenic sin (article 1 and article 2) * Dr. Stanley Plotkin on Meet the Scientist (thanks Peter!) * audioBoo (iPhone app - thanks Jim!) * Audio clips (first and second) from the podcast No Agenda (thanks peripatetic apoplectic!)
Weekly Science Picks
Jennifer Piled Higher and Deeper (PhD Comics)
Vincent Giant Microbes (thanks Stephen!)
Dick Virology in the 21st Century
Alan Annals of the Former World by John McPhee
Vincent and Dick explain virus classification, and revisit the 1976 swine flu immunization campaign and Guillain-Barré syndrome.
Links for this episode: * International Committee on the Taxonomy of Viruses (ICTV) * CBS 60 Minutes on 1976 swine flu vaccine (thanks Gus and Swiss compass!) * Vaccines and Guillain-Barré * NINDS Guillain-Barré Information * Reflections on the 1976 swine flu vaccination program * Swine influenza outbreak at Fort Dix, 1976
Weekly Science Picks
Dick Five Kingdoms: An Illustrated Guide to the Phyla of Life on Earth by Lynn Margulis and Karlene V. Schwartz
Vincent A Genetic Switch by Mark Ptashne
Vincent, Dick, Alan, and Delthia Ricks discuss a new influenza virus-like particle vaccine, dog flu, ultrasensitive pen-sized virus detector, imported rabies in the US, Crimean-Congo hemorrhagic fever, and next season’s flu vaccines.
Hosts Vincent Racaniello, Dick Despommier, Alan Dove, and Delthia Ricks
Links for this episode: * Trivalent virus-like particle vaccine * Canine flu virus vaccine * Ultrasensitive virus detector * Rabies imported into the US * Crimean-Congo hemorrhagic fever in Kazakhstan * FDA approves seasonal flu vaccine for fall * Yields of 2009 H1N1 vaccine are low * FDA may fast-track approval of 2009 H1N1 vaccine
Weekly Science Picks
Delthia 100 questions and answers about influenza by Delthia Ricks
Alan Tinychat Dick Mythbusters
Vincent Effect Measure
In episode 41 of "This Week in Virology", Vincent Racaniello, Dick Despommier, Alan Dove and Rich Condit chat about infectious salmon anemia virus, virus-resistant grapevines, virulence of pandemic H1N1 influenza virus, origin of 1918 influenza virus, holy water ban to halt influenza, frequency of human WU and KI polyomavirus infection, rabies in China, and host species of sin nombre virus.
Links for this episode * Wal-Mart stops buying Chile salmon on virus outbreak * Virus-resistant grapevines * Virulence of H1N1 pandemic influenza virus in animal models * Did 1918 influenza virus originate in birds or not? * Holy water ban to halt swine flu * Frequent Human Infection with WU and KI Polyomaviruses * Rabies in China * Increased Host Species Diversity and Decreased Prevalence of Sin Nombre Virus * Fast, cheap PCR for crime scenes (thanks Jim!)
Weekly Science Picks
Alan For Love of Insects by Thomas Eisner
Rich Making of the Atomic Bomb by Richard Rhodes
Dick *Origin of Species by Charles Darwin
VincentGallileoscope (thanks Zach!)*
In episode 40 of "This Week in Virology", hosts Vincent Racaniello, Dick Despommier, and Alan Dove consider Reston ebolavirus in swine, historical perspective of H1N1 influenza virus emergence and circulation, Tamiflu-resistant H1N1, Tamiflu in Japanese river waters, transmission of H1N1 virus in ferrets, and pneumonia and respiratory failure from H1N1 in Mexico.
Links for this episode * Reston ebolavirus in Philippine swine * Historical perspective on H1N1 virus * Salk's 1947 article on flu vaccine failure * Persistent legacy of 1918 H1N1 virus * Tamiflu resistant H1N1 virus (AP article) * Tamiflu in Japanese river waters * H1N1 infection of ferrets (article one and two) * Pneumonia and respiratory failure from S-OIV in Mexico * DNA-based equine WNV vaccine (thanks Peter!) * Fundamentals of Molecular Virology by Nicholas Acheson
Weekly Science Picks
*Alan Coming to Life* by Christiane Nusslein-Volhard
Dick Monsters Inside Me from Discovery Channel
Vincent Microbeworld****
In episode 39 of This Week in Virology, hosts Vincent Racaniello and Dick Despommier discuss virus structure and answer listener questions.
Links for this episode *** Diagrams of virus structures
-
Boston Globe article on Genzyme
-
FDA warning letter to Genzyme (thanks Peter!)
-
Public Health Reports July - December 1918 (thanks Lenn!)
-
Amateur scientists working with professionals (thanks Ennio!)
-
Influenza H1N1 and computer analogies (thanks swiss compass!)
-
Bone marrow transplant to cure AIDS not reported (thanks Andrew!)
-
Paul Offitt interview on vaccines and autism
-
Mark Crislip on vaccines and autism**
Weekly Science Picks
Dick Visual Explanations by Edward R. Tufte
VincentThe Youngest Science by Lewis Thomas
In episode 38 of This Week in Virology, hosts Vincent Racaniello and Glenn Rall chat about koi herpesvirus, H1N1 influenza vaccine produced in insect cells, attack by a rabid raccoon, and measles.
Links for this episode: * Virus suspected in carp die-off: koi herpesvirus * H1N1 influenza vaccine produced in insect cells with baculovirus vectors * Outbreak of measles in Wales * Production of influenza vaccines in cell cultures: MDCK, Vero, PER.C6, EB66, insect (thanks Peter!)
Weekly Science Picks
Glenn Riddled with Life by Marlene Zuk
VincentAll the Virology on the WWW
In episode 37 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Eric Freed talk about vesivirus contamination of bioreactors, pandemic influenza, maximizing the effect of vaccination by targeting children, chikungunya virus, and open access scientific journals.
Links for this episode: * Genzyme shuts down manufacturing of two enzyme drugs because of vesivirus contamination * Brazilian H1N1 isolate is not novel * WHO interactive H1N1 map * Targeting children maximizes the effect of vaccination * Chikungunya virus and Aedes mosquitoes * Viruses, an open-access virology journal * iBioSeminars * A field study of virus removal in septic tank drainfields
Weekly Science Picks
Alan Forrest Mims (website)
VincentThe Machinery of Life by David S. Goodsell
In episode 36 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Hamish Young discuss the 2009 influenza pandemic, first 2009 H1N1 vaccine, hunting mosquitoes with midges, vaccine-associated polio in India, and adenoviruses.
Links for this episode: * WHO calls it a pandemic * Novartis produces test run of H1N1 vaccine * Midge keeps invasive mosquito in check * Two cases of vaccine-associated polio in India * BBC interactive map of influenza cases * Outbreak of adenovirus type 14
Weekly Science Picks
Dick The World’s Water by Peter H. Gleick
Hamish Guns, Germs, and Steel by Jared Diamond; Complications by Atul Gawande
Alan Eurekalert
Vincent Respectful Insolence
In episode 35 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Richard Kessin talk about Lujo virus, a new arenavirus, influenza, WHO rewriting pandemic rules, adjuvants, and a brief history of microbiology.
Links for this episode: * Lujo virus, a new arenavirus * Is CDC too optimistic about influenza? * WHO to rewrite pandemic rules * Adjuvant at wikipedia * Avery, MacLeod, McCarty 50th anniversary ( pdf)
Weekly Science Picks
Dick Three papers on origins of infectious diseases (one, two, three)
Rich An Imperfect Lens by Anne Roiphe
Alan Zotero, a FireFox plugin
Vincent e! Science News
In episode 34 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, and guest Stephen Morse discuss progressive vaccinia in a smallpox vaccinee, arsenic and influenza in mice, facemasks and flu transmission, and antigenic and genetic analyses of the new H1N1 influenza virus.
Links for this episode: * Progressive vaccinia in a military smallpox vaccinee * Arsenic compromises the immune response to influenza in mice * Facemasks prevent flu transmission in a mathematical model * Serum cross-reactive antibody response to the new H1N1 influenza virus * Antigenic and genetic characteristics of the new H1N1 influenza viruses * Preparation of influenza virus vaccine seeds * Paul Ewald on the evolution of virulence
Weekly Science Picks * Alan Org-Mode * Vincent Human/Swine A/H1N1 Influenza Origins and Evolution * Stephen The Origin of Species by Charles Darwin
Vincent, Alan, Dick, and Raul Andino live at ASM discussed cytomegalovirus infection and blood pressure, restriction of avian influenza viral replication at low temperature, first isolation of West Nile virus in PA, and current status of influenza.
Hosts: Vincent Racaniello, Alan Dove, Dick Despommier, and Raul Andino
Links for this episode:
Cytomegalovirus infection causes an increase of arterial blood pressure
Avian influenza virus glycoproteins restrict virus replication at low temperature
First West Nile virus isolation of the year in PA
CDC press release of 18 May 2009
Glaxo's influenza vaccine with adjuvant
NY Times article on Guillain-Barré and a more scientific view
Weekly Science Picks Dick - National Museum of the History of Science and Medicine, Leiden
Alan - Beginning Mac OS X Programming Vincent - Vaccinated by Paul Offit
Raul - HubbleSite
In episode 32 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Raul Rabadan converse about polio survivors in iron lungs, bocavirus, structure of mimivirus, and genome sequence analysis of influenza H1N1 viruses.
Links for this episode: Death of Marsha Mason, who lived 60 years in an iron lung
First discovery of bocavirus in human stool
Structural studies of the giant mimivirusPandemic potential of H1N1 influenza virus
Was swine flu a lab accident? Bloomberg and NY Times articles
Hong Kong virologist says new H1N1 strain is ‘unstable’
Article by John Barry on site of origin of 1918 influenza
In episode 31 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Marc Pelletier summarize the past week’s influenza H1N1 activity, and discuss parvovirus infection of dogs and humans.
Weekly Science Picks
Marc Celestia, an application
Dick US Geological Survey website
Alan Society for Amateur Scientists website
Vincent Sneeze, an online game
On this special episode of This Week in Virology Vincent Racaniello and Dr. Peter Palese, noted influenza expert, discuss the origin and pandemic potential of the new H1N1 influenza virus.
In episode 30 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier and guest Hamish Young focus on the new H1N1 influenza virus, which originated in swine and is likely to be the next pandemic strain.
Links for this episode:
- Original CDC report of California and Texas outbreak; recent updates here
- Science interview with CDC’s Ruben Donis
- CDC webpage on US status of influenza
- WHO webpage on international status of influenza
- Learn more about the outbreak an influenza virus biology at virology blog
Science blog of the week: GermBlog by Dr. Harley Rotbart
Science podcast pick of the week: Science and the City
Science book of the week: The Swine Flu Affair: Decision-making on a Slippery Disease by by Richard E. Neustadt, Harvey V. Fineberg
In episode 29 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and Dick Despommier talk about insect and human dengue virus host proteins, equine vaccine for WNV and EEEV, return of swine flu to humans, spread of polio in Africa, and listener email.
Links for this episode:
- Discovery of insect and human dengue virus host proteins
- Immunize your horse with PreveNile
- Swine flu returns to California, Texas, Mexico
- Polio spreads from Nigeria to 15 African countries
- Dead Chinese woman on Russian train: no SARS or influenza
- Jenny McCarthy body count
- Ten dumbass reasons why people don’t get their flu shots
Science blog of the week: Science-based medicine
Science podcast pick of the week: WNYC’s Radio Lab
Science book of the week: Flu by Gina Kolata
In episode 28 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier, and Eric F. Donaldson discuss a new test for influenza H5N1, poliovirus in Minnesota, Koala retrovirus, batteries made from viruses, and SARS.
Links for this episode:
- New rapid test for influenza H5N1 based on PDZ binding. Definition of ELISA.
- Poliovirus isolated from Minnesotan (article 1 and 2)
- Koala retrovirus: Japan story and review article
- Batteries made from viruses (cathode and anode). Image of phage M13.
- iMoleBuilder (iTunes link and review at Sunset Lake Software)
- Discovery of Norwalk virus
- Regulatin’ Genes (YouTube link)
Science blog of the week: The Great Beyond by Nature
Science podcast pick of the week: Sorting Out Science
Science book of the week: A Slot Machine, A Broken Test Tube by S.E. Luria (out of print - check your library)
In episode 27 of This Week in Virology, hosts Vincent Racaniello, Alan Dove, Dick Despommier, and Saul Silverstein revisit an ebola virus needlestick accident, and discuss the role of TLR3 in formation of Negri bodies, a New England college closed by norovirus gastroenteritis, hand, foot, and mouth disease outbreak in China, and the exit of herpes simplex virus from latency by synthesis of VP16.
Links for this episode:
- Update on ebolavirus needlestick accident
- Formation of Negri bodies depend upon TLR3
- Norovirus outbreak closes New England college
- Hand, foot, and mouth disease outbreak in China
- Synthesis of VP16 coordinates herpes simplex virus exit from latency
Science blog of the week: Biocurious
Science podcast pick of the week: NPR’s Science Friday
Science book of the week: A Conspiracy of Cells by Michael Gold
Dick’s pick: Andros Island Bonefish Club
Saul’s pick: Secret Science Club
In episode 26 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Rich Condit converse about induction of polyomavirus replication in multiple sclerosis patients treated with the MS drug Tysabri, the extent of human polyomavirus infection, selection of influenza vaccines for the 2009-10 season, cowpox virus transmission from animals to humans, vaccinia-like virus infecting humans and cattle in Brasil, and poxviruses.
Links for this episode:
- JC virus, Tysabri, PML, and mefloquine at virology blog
- Seroepidemiology of polyomaviruses in human
- Next season’s influenza virus vaccines and how they are selected
- Cell-culture propagated smallpox vaccine
- Cowpox tranmission from rats to humans ( Germany and France) and from cats to humans in Italy
- Vaccinia-like virus infecting cows and humans in Brasil
- When good vaccines go wild(review)
- Mosquito Map (thanks Duncan)
- Pfeiffer & Kirkegaard paper on quasispecies and virulence in mice
Science blog of the week: Coevolvers by Devin Drown
Science podcast pick of the week: QuackCast
Science book of the week: Listen to the Music: The Life of Hilary Koprowski by Roger Vaughan
In episode 25 of This Week in Virology, hosts Vincent Racaniello, Alan Dove and guest Luis Villarreal discuss rabies in Viet Nam and Angola, needle-stick infections with ebola virus and West Nile virus, and viral evolution.
Links for this episode:
- Furious rabies after an atypical exposure
- Rabies outbreak in Angola
- Ebola virus needle stick injury in Germany
- West Nile virus needle stick injury in South Africa
- Antibody response to smallpox vaccine in humans (including Dr. Villarreal)
- The chemical formula for polio virus is: C332, 652H492, 388N98, 245O131, 196P7, 501S2, 340. Because poliovirus is a quasispecies, the number of atoms is a population average.
- Review article: Ten Reasons to Exclude Viruses from the Tree of Life
- Origin and Evolution of Viruses, second edition, edited by Esteban Domingo
- Origin of Group Identity by Luis Villarreal
Science blog of the week: Small Things Considered by Moselio Schaechter and Merry Youle
Science podcast pick of the week: The Skeptics’ Guide to the Universe
Science book of the week: Viruses and the Evolution of Life by Luis Villarreal
Vincent, Alan, and Hamish Young discuss bacteriophages in viral vaccines, enteroviruses and diabetes, inhibition of Hendra and Nipah virus replication by the malaria drug chloroquine, and viroids.
Links for this episode:
- Bacteriophages in viral vaccines
- Presence of enteroviral VP1 protein in pancreatic islets of diabetics
- Chloroquine inhibits Hendra and Nipah virus replication
- Review on viroids discovered by TO Diener
- Mumps in Ireland
- CDC information on EBV (thanks Megan!) and Journal of Virology paper (thanks Everett!)
Science blog of the week: The Weekly Virus
Science podcast pick of the week: NIH Research Radio Podcast
Science book of the week: Ahead of the Curve: David Baltimore’s Life in Science by Shane Crotty
Vincent, Dick, and Alan review a new macaque model for HIV-1 infection, a possible role for Epstein-Barr virus in multiple sclerosis, accidental release of H5N1 by a vaccine company, resistance of frogs to virus infection, and extreme virology - the biggest and smallest viruses and viral genomes.
Links for this episode:
- Harold Varmus on The Daily Show
- Macaque model for HIV-1 infection (photo of pig-tailed macaque)
- Possible role of Epstein-Barr virus in multiple sclerosis
- Accidental distribution of H5N1 influenza virus by pharmaceutical company
- Major histocompatibility class I marker and frog resistance to viral infection
- Smallest virion and DNA genome: Circovirus
- Largest virion and DNA genome: Mimivirus
- Biggest RNA genome: (we forgot to mention on the show!) Coronavirus SW1
- List of viral genome lengths at NCBI
- Sputnik virophage
- Papers for Macintosh and iPhone
Science blog of the week: H5N1 by Croft
Science podcast pick of the week: MicrobeWorld video
Science book of the week: Autism’s False Prophets by Paul A. Offit, MD (podcast with Dr. Ginger Campbell)
In episode 22 of This Week in Virology, host Vincent Racaniello and guest host Chris Upton, a professor in the Department of Biochemistry and Microbiology at the University of Victoria in Vancouver, Canada, converse about hepatitis B in India, AIDS gene therapy with a ribozyme, antibodies that neutralize many influenza virus strains, killing tumors with vaccinia virus, myxoma virus of rabbits, and the Viral Bioinformatics Resource Center.
Links in the episode indlude:
- Hepatitis B outbreak in India
- AIDS gene therapy clinical trial
- Antibodies that neutralize many influenza virus strains (papers 1 and 2)
- Vaccinia virus as an oncolytic agent
- Mutations that attenuate myxoma virus in rabbits
- Viral Bioinformatics Resource Center
Science blog of the week: The VBRC blog by Chris Upton
Science podcast pick of the week: Nova ScienceNow
Science book of the week: The Hot Zone by Richard Preston
In episode 21 of This Week in Virology, hosts Vincent Racaniello, Dick Despommier, Alan Dove, and special guest Max Gottesman, discuss an unusual wasp-virus symbiosis, influenza transmission and absolute humidity, how mosquitoes survive Dengue virus infection, and viruses of bacteria.
Links in the episode indlude:
- Unusual wasp-virus symbiosis
- Absolute humidity modulates influenza virus transmission, survival, and seasonality
- How mosquitoes survive Dengue virus infection
- Little Lambda, Who Made Thee?
- Structure of HK97 procapsid
Science blog of the week: BioJobBlog by Cliff Mintz
Science podcast pick of the week: Distillations - a weekly science podcast that brings you extracts from the past, present, and future of chemistry
Science book of the week: The Life of a Virus by Andrea Creager
Vincent, Dick, Alan, and Matt Evans converse about TED, the Wakefield autism controversy, 99 rhinovirus sequences, Marburg in the USA, and hepatitis C virus.
Vincent and Alan discuss cap-snatching by the hantavirus N protein and the influenza virus endonuclease, HIV-1 and Ebola virus antagonism of tetherin, and influenza pneumonia.
Vincent, Dick, and Alan discuss adenovirus type 36 and obesity, new influenza antiviral drugs, viral hemorrhagic septicemia virus of fish, and Ebola virus in pigs and pig farmers in the Phillipines.
Vincent, Dick, and Saul talk about discoveries in virology that have had a major impact on the field.
Sem•i•nal (adjective): strongly influencing later developments.
Note: There are two HPV vaccines on the market: Gardasil (quadrivalent, types 6, 11, 16, 18) and Cervarix (bivalent, types 16 and 18).
Links for this episode:
Gates Foundation donates to polio eradication effort.
Testing a bivalent oral poliovirus vaccine in India.
We played a clip from net@night episode 83.
I wrote about Jonathan Swift’s ‘Animalcules’ on virology blog.
Science blog of the week: Research Blogging
Science podcast pick of the week: Boston Museum of Science podcast
Science book of the week: The Lives of a Cell: Notes of a Biology Watcher by Lewis Thomas
Vincent and Jeremy, in Saanen, Switzerland, review the 19th Challenge in Virology meeting, and implications of a new HIV-1 sequence from 1960 for the origin of AIDS.
Links for this episode:
NY Times article on Offit vaccine book.
Nature paper on new 1960 HIV-1 sequence.
Massive polio immunization in Pakistan.
PLoS paper on T cell responses to HERVs in HIV-1 infection.
Science blog of the week: Eye on DNA by Dr. Hsien-Hsien Lei
Science podcast pick of the week: Persiflager’s Infectious Disease Podcast
Science book of the week: Microbe Hunters by by Paul de Kruif
Vincent, Dick, and Alan converse about hantavirus spread by large deer mice, why the 1918 influenza virus replicates in the lower respiratory tract, measles in Europe, and the growing resistance of influenza virus to antivirals.
Links for this episode:
MMWR, Morbidity and Mortality Weekly Report from CDC.
Larger, older deer mice spread hantavirus.
Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets.
Measles in Europe: an epidemiological assessment.
Avian flu (H5N1) gaining resistance to antivirals.
Times article on resistance to Tamiflu and analysis by virology blog.
Angola widens border closure with DRC over Ebola.
Solutions, the iPhone/iPod Touch app to calculate molar solutions.
Vaccine, the iPhone/iPod Touch app to determine vaccination schedules.
Science blog of the week: Molecule of the Day
Science podcast pick of the week: Meet the Scientist by Merry Buckley
Science book of the week: The Great Influenza by John M. Barry
The Origin of Species by Charles Darwin - published 150 years ago.
Vincent and Alan discuss a viral upper respiratory tract infection, transmission of H5N1 influenza virus, death of an HIV denialist, and the Ebola outbreak in the Democratic Republic of the Congo.
Links in this episode:
PLoS Pathogens paper on transmission of H5N1 influenza virus.
Ebola outbreak in DRC reported by ProMedMail.
Death of HIV denialist.
BioCrowd, a network for bioscientists.
Molecules, the iPhone/iPod Touch app to display molecules.
Science blog of the week: ViroBlogy
Science podcast pick of the week: Astronomy Cast
Science book of the week: The Cutter Incident by Paul A. Offit, MD
Vincent and Alan talk about President-elect Obama’s choices for his science advisors, SARS sensationalism, a new enteric picornavirus, and the top 10 virology stories of 2008.
Obama’s science advisors (Yahoo story)
CDC RSS feed on influenza
PNAS paper on a new enteric picornavirus
TWiV’s top 10 virology stories of 2008:
- Nobel Prize in Medicine to Montagnier, Barré-Sinoussi, and zur Hausen
- AIDS elite controllers partly explained
- Cancellation of PAVE HIV-1 vaccine trial
- Gut homing receptor for HIV-1
- New Ebola strain
- New mosquito virus
- How mosquitoes survive virus infection
- Mouse model for Chikungunya
- Genome sequences of 150 avian influenza virus strains
- Understanding the RS virus vaccine failure
Science blog of the week: Aetiology
Science podcast pick of the week: biobytes
Science book of the week: Principles of Virology, 3rd Edition by Flint, Enquist, Racaniello, and Skalka.
Vincent, Alan, and Angela discuss Kuru, prions in milk, ancient lentiviruses found in the chromosomes of lemurs, a respiratory syncytial virus vaccine failure in the 1960s, and recent outbreaks of H5N1 influenza in chickens.
Links for this episode:
D. Carleton Gajdusek obituary in the NY Times. We forgot to mention that he won the 1976 Nobel Prize in Medicine for his work on Kuru.
PLoS Pathogens article on prions in sheep milk.
PNAS article on endogenous lemur lentivirus
Nature Medicine article on the failed respiratory syncytial virus vaccine.
December 18 was the 100th anniversary of the discovery of poliovirus.
Science podcast pick of the week: Skepticality.
Science book of the week: Science Fictions: A Scientific Mystery, a Massive Cover-up and the Dark Legacy of Robert Gallo by John Crewdson.
Vincent, Alan, and Jeremy discuss why certain AIDS patients, called ‘elite controllers’ or ‘long-term non-progressors’, do not develop disease, why mosquitoes infected with Sindbis virus remain healthy, and the continuing outbreaks of norovirus gastroenteritis.
Links for this episode:
Immunity article on elite controllers.
PNAS article on protected mosquitoes.
The word quarantine comes from the seventeenth century Venetian quarantena, which means forty day period.
Science podcast pick of the week: The Mr. Science Show
Science book of the week: Arrowsmith by Sinclair Lewis. Click here to see a page from my Mother’s marked-up copy. She was a high school English teacher.
Vincent, DIck, and Alan chat about reconstruction of a bat SARS-like coronavirus, herpesviruses that are killing elephants in zoos, and a plan to eradicate AIDS in ten years.
Links for this episode:
The Virology Network at socialmedian.com.
The bat SARS-like coronavirus: scientific article in PNAS, and the Wired Science article.
NY Times Editorial on eradicating AIDS.
Herpesviruses killing elephants.
Science podcast pick of the week: Futures in Biotech.
Science book of the week: Principles of Molecular Virology, by AJ Cann.
Vincent and Dick recall the discovery of Lassa virus in Africa in 1969. A non-fictional account of the story, ‘Fever’, written by John G. Fuller and published in 1974, inspired Vincent to become a virologist. Part of the story took place at Columbia-Presbyterian Hospital (now Columbia University Medical Center), where both Vincent and Dick are employed. Dick remembers many of the key players in this medical drama.
Links for this episode:
Click here to view to cover of ‘Fever!’
Buy a used copy of ‘Fever!’ at Amazon.
Science podcast pick of the week: The Naked Scientists (iTunes link).
Vincent and Dick converse about warfare preventing immunization of 120,000 children in Afghanistan, bone marrow transplant curing AIDS patient, Google tracking flu, measles outbreak in Gibraltar, using viruses to make batteries, and small mosquitoes and Dengue.
Article on using viruses to make batteries (PubMed: Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes).
Science podcast pick of the week: NY Times Science Times (iTunes link).
Vincent, Dick, and Aidan discuss how viral infections play prominent roles in notable video games. Three games are discussed: World of Warcraft, Pandemic II, and Bioshock.
An article on how World of Warcraft became a model for the transmission of virus infections was published in Lancet Infectious Diseases. The title of the article is “The untapped potential of virtual game worlds to shed light on real world epidemics.”
After we did the netcast we learned of a game for the iPhone called ‘Virus’. In this game your body is infected with a virus, and you must clear the infection by controlling white blood cells. The game is at the iTunes App store.
Science podcast pick of the week: MicrobiologyBytes.
TWiV is now part of Sciencepodcasters.
Hosts: Vincent Racaniello and Dickson Despommier
Dickson was at Pop!Tech last week.
Neal Stephenson’s Cryptonomicon.
US Geological Survey Disease Maps.
CDC page on Hendra and Nipah viruses.
The flying fox (Google image search).
Vincent’s virology course.
Vincent’s texbook is Principles of Virology, third edition, ASM Press (available December 2008).
Science podcast pick of the week: Brain Science Podcast.
Host: Vincent Racaniello
Special guest: Saul Silverstein
Dickson Despommier is away this week at Pop!Tech.
CDC pages on herpes and zoster (shingles).
Hosts: Vincent Racaniello and Dickson Despommier
CDC page on rabies
Dick’s Ecology 101 course
Ecotone defined
Negri bodies defined (down on the page)
Hosts: Vincent Racaniello and Dickson Despommier
Article on the mortgage crisis and West Nile virus in Emerging Infectious Diseases.
Environment-oriented review of Dengue.
Dengue page at the World Health Organization.
Hosts: Vincent Racaniello and Dickson Despommier
polioeradication.org for the latest information on the global state of polio.
Abstract of the Science article on engineering a new polio vaccine: “Virus attenuation by genome-scale changes in codon pair bias”.
Hosts: Vincent Racaniello and Dickson Despommier.
Buy “West Nile Story” by Dickson Despommier.
ProMed Mail. The global reporting system for outbreaks of emerging infectious disease.
PubMed. A service of the National Library of Medicine, includes over 14 million citations for biomedical articles back to the 1950s.
West Nile page at Centers for Disease Control and Prevention. Great maps of where the virus has been found.