In conversation with...: Recent Episodes
The Lancet Infectious Diseases
Our Editors and the journal’s authors explore their research and its impact on people’s health, health care, and health policy in this regular podcast.
Fernando Tortosa and Ariel Izcovich discuss various aspects of hantavirus infections with a focus on the situation in Argentina, including transmission, epidemiology, clinical course, management, latest research developments, difficulties in conducting clinical trials, and future research priorities. The speakers also discuss the main findings and clinical implications of a study 'Use of tocilizumab for severe hantavirus pulmonary syndrome: a MEURI case series with contextual comparisons' they recently published in the journal.
Click here to read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00285-9/abstract
The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.
Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall
Podcast editing: Matteo Simonetti
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Dr Brecht Ingelbeen and Dr Daniel Valia join Senior Editor Phoebe Hall to discuss a new trial in the journal (the CABU-EICO trial) testing a co-created behavioural intervention bundle to improve antibiotic use, patient management, and water, sanitation and hygiene in rural communities in Burkina Faso and DR Congo.
They explain why the study focused on community prescribing (not hospitals), the primary endpoint was a reduction in WHO AWaRE Watch antibiotics (not overall antibiotics), and the intervention targeted all providers of antibiotics in the community, including informal vendors.
Finally, they discuss the importance of designing an intervention bundle that was truly tailored to local context yet practical, sustainable, and scalable beyond the study sites. A parallel study reporting the effect of the intervention bundle on ESBL-producing Escherichia coli colonisation (a co-primary outcome of the trial) is in press at The Lancet Microbe.
To read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00169-6/fulltext
The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.
Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall
Podcast editing: Matteo Simonetti
Visit https://www.thelancet.com/multimedia to learn more about our multimedia offering.
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Sara Tartof and Matan Yechezkel discuss a new article in The Lancet Infectious Diseases about emerging doxycycline resistance against gonorrhoea and its wider implications for the implementation of doxycycline and the prevention of bacterial sexually transmitted infections.
Click here to read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00123-4/fulltext
The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.
Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall
Podcast editing: Matteo Simonetti
Visit https://www.thelancet.com/multimedia to learn more about our multimedia offering.
Find the best science for better lives at lancet.com
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Dr Jenny Clarke and Herve Semukunzi discuss a study they and colleagues recently published with us titled ‘Infection- and vaccine-induced mpox antibodies: validation of a combined mpox IgG ELISA during the clade 1b outbreak in Rwanda’.
They also discuss the reasons for the paucity of validated serological assays for mpox, particularly in outbreak regions where they are most urgently needed.
Click here to read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(26)00006-X/fulltext
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The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.
Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall
Podcast editing: Matteo Simonetti
Visit https://www.thelancet.com/multimedia to learn more about our multimedia offering.
Find the best science for better lives at lancet.com
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Dr Julia Moore Vogel and Dr Danilo Buonsenso discuss various aspects of long COVID including epidemiology, pathophysiology, underlying mechanisms, management, latest research developments, difficulties in conducting clinical trials, and future research priorities.
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The Lancet Infectious Diseases in conversation with... is part of the Lancet Group podcast offering.
Editorial team: editor-in-chief Ursula Hofer, deputy editor Marco De Ambrogi, and senior editors Syeda Saleha Hassan and Phoebe Hall
Podcast editing: Matteo Simonetti
Visit https://www.thelancet.com/multimedia to learn more about our multimedia offering.
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Professors Steven Tong and Joshua Davis discuss all aspects of adaptive platform trials including advantages, disadvantages, differences from conventional trials, and tips for setting up and assessing them.
They also highlight several adaptive platform trials currently in the pipeline that could influence infectious disease clinical practise in the future.
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Professor Ana Odone, Dr Jesus Rodriguez-Manzano, and Dr Alex Howard discuss their new Series of papers on artificial intelligence and infectious diseases intended to support the infectious diseases community in understanding this evolving landscape and in actively shaping artificial intelligence integration into practice.
Read the full Series here:
https://www.thelancet.com/series-do/artificial-intelligence-and-infectious-diseases?dgcid=buzzsprout_icw_podcast_laninfaiandid25_laninf
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Drs Catherine Liu and Joshua Hill of the Fred Hutchinson Cancer Center discuss their new Series of papers on the prevention and management of infections in people who are immunocompromised, with a focus on prevention of infections and diagnostic and antimicrobial stewardship.
Read the Series papers:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00345-7/fulltext?dgcid=buzzsprout_icw_podcast_August_25_laninf
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00311-1/fulltext?dgcid=buzzsprout_icw_podcast_August_25_laninf
Read the linked Comment:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00355-X/fulltext?dgcid=buzzsprout_icw_podcast_August_25_laninf
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Lilian Tina Minja and Norbert Heinrich discuss the SUDUCO and DECODE trials in The Lancet Infectious Diseases on two new promising TB drugs, sutezolid and delpazolid, respectively. They also discuss the wider implications of the findings of these trials for TB drug development and treatment.
Read the trials:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00213-0/fulltext?dgcid=buzzsprout_icw_podcast_July_25_laninf
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00289-0/fulltext?dgcid=buzzsprout_icw_podcast_July_25_laninf
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Leonardo Basso and Juan Pablo Torres discuss their study in The Lancet Infectious Diseases on the effectiveness and impact of the first season of Chile's national immunisation programme with nirsevimab. They discuss the evidence that led to the design and implementation of the programme, its impact on RSV burden and the Chilean health system, and lessons for other countries in the region and beyond.
Read the full article at: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00233-6/fulltext?dgcid=buzzsprout_icw_podcast_10-06-25_laninf
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Jan Felix Drexler and Fernando Bozza discuss their recent study published in the journal— “The spatio-temporal ecology of Oropouche virus: a laboratory-based modelling study across Latin America” and its wider implications for Oropouche virus and other arboviruses transmission, expansion, surveillance, and control.
Read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00110-0/fulltext?dgcid=buzzsprout_icw_podcast_14-04-25_laninf
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Prasad Kulkarni discusses a new Phase I trial in The Lancet Infectious Diseases on a dengue monoclonal antibody also known as VIS513 in healthy adults. In addition, he highlights the wider implications of this for dengue control and drug development.
Read the full article:
https://www.thelancet.com/journals/laninf/article/ S1473-3099(24)00030-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_laninf
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Oriol Mitjà discusses a new trial in The Lancet Infectious Diseases on the use of oral linezolid compared with benzathine penicillin G for the treatment of early syphilis in adults. He also highlights what the trial means for treatment of syphilis.
Read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00683-7/fulltext?dgcid=buzzsprout_icw_podcast_generic_laninf
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Sofia Viegas and Stefan Niemann discuss a new article in The Lancet Infectious Diseases about emerging bedaquiline resistance in Mozambique and its implications for drug resistant tuberculosis and the fight to end tuberculosis.
Read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00498-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_laninf
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Luciano Moreira and Henrik Salje discuss a new article in The Lancet Infectious Diseases describing the use of the Wolbachia bacteria to control the spread of mosquito-borne dengue and chikungunya in Rio de Janeiro, Brazil.
Read the full article:
Estimating the effect of the wMel release programme on the incidence of dengue and chikungunya in Rio de Janeiro, Brazil
Richard Maude discusses a new article in The Lancet Infectious Diseases that assesses the efficacy of malaria chemoprophylaxis among forest goers in Cambodia.
Read the full article:
Antimalarial chemoprophylaxis for forest goers in southeast Asia
Ben Cowling discusses a new article in The Lancet Infectious Diseases describing the protection that vaccines are providing against COVID-19 in Hong Kong.
Read the full article:
Vaccine effectiveness of one, two, and three doses of BNT162b2 and CoronaVac against COVID-19 in Hong Kong
Hugh Adler discusses a new article in The Lancet Infectious Diseases describing the management and the clinical features for seven patients with monkeypox hospitalised in the UK between 2018 and 2021.
Read the full article:
Clinical features and management of human monkeypox: a retrospective observational study in the UK
Prof Beate Kampmann, Dr Karen Keddy, and Prof Peter Ghazal discuss a new cross-journal Series in The Lancet Infectious Diseases and EBioMedicine addressing the potential for and challenge of applying big data to childhood infectious diseases in LMICs.
Read the full Series:
https://www.thelancet.com/series/big-data-childhood-infections-LMICs
A new article highlights how changing immunity profiles motivate the need for better responses to outbreaks of polio in Africa.
Read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00453-9/fulltext
Paul Chapman and colleagues presents the results of an innovative trial assessing the safety of vaccinating healthy volunteers with attenuated Necator americanus hookworm larvae.
Read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00153-5/fulltext
Josep Llibre discusses a trial on the impact of same-day testing for SARS-CoV-2 infection before a concert on new COVID-19 cases in Barcelona, Spain.
Read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00268-1/fulltext
Yap Boum (MSF) discusses his study done in Cameroon, which developed a promising testing strategy for COVID-19 to optimise the available resources.
Read the full article:
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00132-8/fulltext
Two studies in The Lancet Infectious Diseases describe how the spread of resistance to both dihydroartemisinin and piperaquine is compromising malaria therapy in South-East Asia
A trial investigates the use of a cocktail of phages for the therapy of infections in patients with burns.
Editor of The Lancet Infectious Diseases, John McConnell, discusses the 1918 influenza pandemic and the lessons that can be learnt from it with John Oxford and Jeffery Taubenberger.
Amir Shroufi discusses the early results assessing the safety and efficacy of the combination of bedaquiline and delamanid against drug-resistant tuberculosis.
John Beigel, an author, and Eddie Sullivan discuss a phase 1 study assessing the safety and tolerability of human antibodies manufactured in transchromosomic cows for treatment of MERS.
Valentina Cambiano discusses the cost-effectiveness of pre-exposure prophylaxis medication in the UK.
Kit Fairley discusses The Lancet Infectious Diseases' new Commission on sexually transmitted infections.
In our latest Chinese-language podcast, Linjuan Li discusses the epidemiology and evolution of infectious diseases in China in the decade since SARS with Lancet editor Helena Wang.
In this special Chinese language podcast, Helena Wang is joined by two authors of papers on MCR-1 to discuss their research.
Katherine Gibney discusses her paper on geographic variations and sociodemographic inequities in infectious disease notifications in Australia.
Rob Aldridge discusses the prevalence of and risk factors for tuberculosis in UK migrant.
Ana de Filippis discusses research on how Zika virus has been detected in the amniotic fluid of two pregnant women in Brazil.
Ramanan Laxminarayan discusses the implications of antibiotic resistance for prophylaxis.
Discussion of the effects of national antibiotic stewardship and infection prevention and control programmes on MRSA prevalence in Scotland.
Mateusz Plucinski of the CDC discusses how Ebola has affected malaria control in Guinea.
Simon Brooker discusses a study looking into the feasibility of interrupting transmission of soil transmitted helminths.
Arie van der Ende discusses a study looking into incidence of invasive group B streptococcal disease in newborn babies.
Herman Goossens talks to Nicolai Humphreys about new research into antibiotic use in eastern Europe.
Yonatan Grad discusses the genomic epidemiology of antibiotic resistant gonorrhoea in the USA.
Sunil Badve discusses the use of antibacterial honey for the prevention of infections related to peritoneal dialysis.
Didier Menard discusses an assay which can identify artemisinin resistance in plasmodium falciparum malaria.
Heidi Larson discusses an article about the use of existing public health surveillance systems to monitor public confidence in vaccine programmes.
Daniela de Angelis discusses HIV incidence in England and Wales among men who have sex with men.
Paul Little discusses a trial to assess the value of antibiotic prescription for lower respiratory tract infection.
Gillian SteelFisher discusses the public health response to the 2009 H1N1 influenza pandemic.
Discussion of the direct and indirect effectiveness of an oral cholera vaccine deployed in a mass vaccination campaign in Zanzibar.
August issue highlights, including malaria vector control, meningitis type B vaccine, and HPV vaccination targeted at boys and young adults.
This month's Lancet Infectious Diseases podcast looks at a new mortality estimate for 2009 H1N1 flu pandemic.
Discussion of a Review about poor-quality antimalarials, and other June issue highlights.
John McConnell discusses highlights from the May issue of The Lancet Infectious Diseases.
February highlights, including discussion of HIV therapy, rotavirus, polio vaccination, and surgery for drug-resistant TB.
Mike Osterholm discusses the effectiveness of influenza vaccines based on a new meta-analysis of published studies.
Peter Hayward with a 10th anniversary discussion of the journal's progress, and updated reviews on yellow fever and tuberculosis.
June highlights, including discussion of the outcomes of immigrant screening with IGRA to improve tuberculosis control and prevention.
May issue highlights, including discussion of research about NDM1 environmental dissemination in New Delhi.
April issue highlights, including a randomised trial about switching of antiretroviral therapy for children with HIV.
HIV prophylaxis in pregnancy, and research highlighting concerns about current guidelines for treating nosocomial pneumonia.
November issue highlights, including discussion of hepatitis B vaccination, enterovirus 71, and malaria.
October issue highlights, including discussion of malaria treatment in Burma, and HIV incidence in France.
John McConnell discusses the media reaction to the recent NDM-1 antibiotic resistance research article.
Diagnostic testing for syphilis and sleeping sickness, and discussion of infectious disease risks around the FIFA World Cup.
Discussion of February highlights, including the link between infection and coronary artery disease.
John McConnell discusses HIV vaccine progress, and the urgent need for a dengue vaccine.
Discussion of pandemic influenza H1N1, and antiretroviral therapy in low-income and middle-income countries.
John McConnell discusses H1N1 influenza, climate change, and community associated MRSA.
John McConnell discusses the Systematic Review about incubation periods for respiratory infections, and other content highlights.
John McConnell discusses issue highlights including the Review on hypoxaemia in children, and the potential of probiotics in the management of C Difficle infection.
John McConnell discusses a tuberculosis themed issue ahead of World TB Day on March 24.
Sally Hargreaves discusses reviews on staphylococcus aureus disease in SE Asia, and the global burden of hepatitis C infection.
John McConnell reports on the health-care associated infections conference and issue highlights.
John McConnell discusses commercial assays for C difficile diagnosis, antimicrobial catheters, and Acinetobacter baumannii.
John McConnell discusses reviews on microbicides for HIV prevention, and Hepatitis E, and highlights the Nobel Prize for Medicine featured in this month's Leading Edge.
John McConnell discusses highlights from the October issue, including the stockpiling of flu vaccines as part of preparedness planning for a future influenza pandemic.
Editor of TLID, John McConnell, discusses infectious disease surveillance, heterosexual infectivity of HIV, and antibiotics for treatment of acute sinusitis in this issue's podcast.
Pam Das and Sally Hargreaves discuss highlights from the August issue of The Lancet Infectious Diseases ahead of the World AIDS meeting in Mexico next month.
MRSA, typhus, and STOP TB: Hospital-acquired MRSA, the potential bioterrorism threat of typhus, and an analysis of the STOP TB partnership are discussed in a podcast.
The June issue of The Lancet Infectious Diseases includes discussion of the female condom, introduced in Europe 15 years ago, but still a neglected tool for protection against pregnancy and sexually transmitted infections, especially HIV. Sally Hargreaves discusses the potential role of the female condom, including its use in areas with high HIV prevalence, with Susie Hoffman and Theresa Exner, from Columbia University, New York City, USA, in this month's podcast.
'The pieces are increasingly in place to achieve the Secretary General's vision for universal coverage and make rapid gains toward ending malaria deaths in Africa. With one child dying every 30 seconds from malaria in Africa, we have not a moment to lose'. In a joint podcast between The Lancet and The Lancet Infectious Diseases, Sally Hargreaves assesses renewed efforts to scale up prevention and treatment of malaria, coinciding with World Malaria Day on April 25.
John McConnell and Richard Lane discuss highlights from the April issue, including the Leading Edge Editorial commenting on the US Food and Drug Administration proposal for superiority trials to be required before the licensing of anti-infective drugs. Also discussion of a review on syphilis, a sexually transmitted disease whose incidence is increasing after rapid decline in the 1980s and 1990s.
Sally Hargreaves discusses highlights from the March issue: a review about the emergence of multidrug-resistant Enterobacteriaceae that produce extended-spectrum β-lactamases (ESBLs) within the community setting, an important cause of urinary-tract infections. Also discussed is a feature and the editorial about human papilloma (HPV) vaccination programmes, and the review about Whipple's disease, a condition which is both rare and poorly understood.
In September, 2006, a group of experts in antimicrobial research met to discuss the problems arising from the emergence of antibiotic resistance in health-care-associated Gram-negative bacteria and the lack of new antibacterial agents to challenge this threat.
John McConnell and Richard Lane discuss three reviews in the January issue: influenza vaccination in pregnant women; a meta-analysis of the antibiotic linezolid in the treatment of gram-positive bacterial infections; and a discussion of paediatric infection control, especially in the hospital setting, where children are at an increased risk of infection than adults.
Sally Hargreaves discusses highlights from the December issue: private sector investment in global health, especially HIV/AIDS, outlined in the Leading Edge and in a Newsdesk item; reviews on human brucellosis disease and meningococcal disease; and discussion of the feature concerning the forced isolation of individuals with tuberculosis in South Africa.
John McConnell discusses highlights from the November issue: a Review of bacterial genome sequencing and its use in infectious diseases, a Review of Rocky Mountain spotted fever, and an Editorial on The Global Fund to fight AIDS, Tuberculosis and Malaria.
John McConnell discusses highlights from the October issue: a Leading Edge calling for canine rabies vaccination, and three Reviews; influenza vaccination among elderly people, intravascular catheter-related infections, and the benefit of vaccination among injecting drug users.
John McConnell dicusses a review about cutaneous leishmaniasis, a neglected parasitic disease; a meta-analysis investigating the association between mycobaterium avium paratuberculosis and Crohn's disease; and an unusual personal view about how the virtual gaming world could help us prepare strategies in the event of real-life disease epidemics
Senior Editor Sally Hargreaves from The Lancet Infectious Diseases discusses topics from the August issue: including a leading edge on prison health and communicable diseases, and a review on cholera by Jane Zuckerman and colleagues at the WHO Collaborating Centre for Travel Medicine.
John McConnell and Richard Lane discuss highlights from the July issue: a meta-analysis suggesting that the herbal product echinacea can reduce the chance of catching a cold by 58% and reduce the length of a cold by 1.4 days; also discussed is the article documenting worldwide HPV prevalence of 10%, and the leading edge editorial about the recent G8 summit.
Sally Hargreaves discusses the editorial in the June issue concerning health policies for migrants. Many countries adopt screening programmes which in some cases fail to be cost-effective and confer few benefits to public health. Also discussed are the reviews about universal screening of infants for hepatitis B, and the parasitic disease cystic echinococosis.
Editor John McConnell discusses highlights from the May issue: a resurgence of chikungunya infection around the Indian Ocean and a review about the need to be strain-specific in order to develop new prevention and treatment strategies for tuberculosis.
Editor John McConnell discusses highlights from the April issue, including a review assessing the mode of transmission for Influenza A, the publication of the ORION statement aiming to improve standards of research in infection control in hospital settings, and the review on human t-cell lymphotropic disease
John McConnell highlights the March issue, including a review about diagnosing bacterial meningitis in emergency settings, procalcytonin and the diagnosis of sepsis.
Every year, around 50 million pregnant women worldwide are exposed to malaria; the consequences of which can be devastating for both the mother and her unborn child. Pam Das outlines eight reviews providing insight into pregnancy-associated malaria.
Editor John McConnell discusses the highlights of the January issue of TLID, including a review on HIV in prisons in low- and middle-income countries, guidelines from WHO on the treatment of avian influenza, and a Forum article on anti-infective research.
Editor John McConnell discusses highlights from The Lancet Infectious Diseases December issue, including a Leading Edge on antibiotic approval, a Review of scabies, and a Personal View on rotavirus vaccine.
Pam Das And Richard Lane discuss the highlights from the November issue. The topics covered include treatment standards for tuberculosis, future possibilities for a vaccine against diseases caused by worm infestations.
Pam Das and Richard Lane discuss highlights from the October issue, including reviews about hand hygiene, and quinolone resistance.