Stem Cell Channel (Video): Recent Episodes
UCTV
Stem cell science is changing medicine and our understanding of human development. The Stem Cell Channel takes you into the labs where cutting edge-research takes place, introduces you to the scientists leading the way, and breaks down how these amazing discoveries impact everyday life and health.
Heart regeneration faces two connected challenges: replacing lost muscle and keeping transplanted cells safe and accepted by the body. Charles Murry, M.D., Ph.D., of USC explains why the adult heart heals major cardiomyocyte loss with scar tissue rather than new muscle, leading to progressive heart failure. Murry describes how stem cell derived cardiomyocytes can be manufactured at scale, transplanted into injured hearts, and tested for function in animal models. He also examines major barriers, including graft related arrhythmias, calcium handling stress, immune rejection, and the need for practical immunosuppression or immune edited cells. By connecting cell manufacturing, electrophysiology, immunology, and clinical trial planning, this research shows why heart regeneration is difficult and why careful translation matters for patients with severe heart injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40853]
Hematopoietic stem cells make blood across the lifespan, but they do not all behave the same way. Stephanie Xie, Ph.D., Scientist at Princess Margaret Cancer Centre, University of Toronto, examines how these rare cells self-renew, differentiate, and respond to inflammatory stress, asking whether differences in the stem cell pool help explain why aging affects people so differently. Xie identifies two hematopoietic stem cell subsets, including one that retains inflammatory memory after stress recovery, and connects this state to aging, clonal hematopoiesis, sickle cell disease, post-COVID recovery, and mortality risk markers in blood. Her research also raises questions about whether targeting the inflammatory environment, including through GLP-1 receptor agonists or metformin, could help mitigate clonal hematopoiesis. Understanding these patterns could clarify how inflammation shapes blood production, cancer risk, and immune health over time. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41406]
Rare disease research is creating new paths for diagnosis, treatment, and broader medical discovery. Gene therapy can repair or replace faulty genes, and work on cystinosis has led to a stem cell platform now being applied to Danon disease, Sanfilippo syndrome C, Friedreich’s ataxia, and Alzheimer’s research. Funding programs support gene therapy, clinical trials, and new platform approaches for rare diseases. CAR-T cell research is also advancing treatment possibilities for pediatric brain tumors, including early results in children with DIPG and diffuse midline glioma. A patient advocate shares her daughter’s diagnostic odyssey and treatment for TUBB4A leukodystrophy. Together, these stories show why rare disease research matters beyond rarity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41402]
Pre-cancer and cancer can begin when stressed blood-forming stem cells lose their normal controls. Catriona Jamieson, M.D., Ph.D., UC San Diego, explains how inflammation-linked editing enzymes, repetitive elements in the genome, and stem cell stress shape the progression from myeloproliferative neoplasms to acute myeloid leukemia. Jamieson examines how spaceflight accelerates stem cell aging, how some astronauts mobilize a resilient regenerative stem cell population, and how tumor organoids in space help reveal drug responses by activating the enzyme ADAR1. This work helps explain how cancer starts, why it can return, and how space-based research may speed the development of therapies that stop malignant stem cells before disease advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41473]
Space healthcare depends on connected health data that can follow people wherever care happens. Peter DeVault, Epic, explains how electronic health record tools built for hospitals, labs, and patients can also support healthcare in space. DeVault describes patient-facing tools like MyChart, interoperability across health systems, structured genomics and pharmacogenomics in the patient record, and Cosmos, Epic’s patient data aggregation platform with about 300 million longitudinal records. He also examines AI capabilities that can generate possible future health scenarios and expand to telemetry and molecular data collected before, during, and after a mission. This work helps explain how records, data sharing, and predictive tools could support astronaut health and resilience and why those capabilities may be necessary for the future of space medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41481]
Brain aging and disease research can gain new insights from space. Aline M.A. Martins, Ph.D., UC San Diego, explains how neuroscience studies in space use brain organoids, proteomics, and single-cell analysis to understand cognition decline, space-induced neurosenescence, and disease-related changes. Martins examines molecular markers of senescence, mitochondrial impairment, and neuroinflammation in organoid models, including Rett syndrome, while also comparing how space affects organoids of different ages. She shows that space can accelerate aging-related changes and affect cell types differently, helping clarify how space biology may speed drug discovery and reveal biomarkers for disease. This work helps explain how space research can inform treatments on Earth and points toward faster preclinical testing and broader understanding of brain disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41478]
Microgravity can change biological systems in ways that may open new paths for biomedical research and commercialization in space. Twyman Clements, Space Tango, explains how “middleware” helps connect research use cases with space infrastructure by adapting terrestrial processes and supply chains for a spaceflight environment. Clements examines how long-duration microgravity creates different physical conditions, how Space Tango packages experiments into flight-ready lab systems, and how commercial space stations and reentry systems could help increase scale, throughput, and production value. He also points to more robotic systems that could support on-orbit sampling, imaging, and experiment assembly. This work helps explain how space-based biomedical research could move beyond small experimental missions and toward more practical, scalable platforms for discovery and development Series: "Stem Cell Channel" [Science] [Show ID: 41480]
Stem cell health in space matters for astronaut health and cancer research. Jessica Pham, UC San Diego, explains how spaceflight shapes normal hematopoietic stem cells and cancer stem cells through nano bioreactor studies, astronaut blood analysis, and tumor organoid work in low-Earth orbit. Pham examines increased cycling and reduced dormancy in space, reduced self-renewal after return, and ongoing research on cancer stem cells and their microenvironment, helping clarify how stem cells respond to spaceflight. This work helps explain how space conditions may change stem cell fitness over time and points toward a better understanding of astronaut health, long-duration missions, and cancer stem cell behavior. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41477]
Brain aging and neurological disease are hard to study because living human brain tissue is difficult to access. Alysson Muotri, Ph.D., UC San Diego, explains how brain organoids sent to space can model accelerated aging, reveal changes in neural networks, and help test potential treatments for brain disorders. Muotri examines space-induced senescence, fragmented network activity linked to dementia and Alzheimer’s patterns, and Rett syndrome findings showing inflammation tied to endogenous retroviruses and response to antiretroviral drugs in preclinical models. He also explores using brain organoids in space to screen neuroprotective compounds, including candidates identified from Amazon plants. This work helps explain how space biology can speed research on autism, Rett syndrome, Alzheimer’s disease, and other neurological conditions, and points toward new ways to test therapies on Earth. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41475]
Cognitive resilience depends on how the brain responds to environment, aging, and inflammation. J. Tiago Gonçalves, Ph.D., studies the hippocampus to examine how spatial memory is shaped by factors such as cognitive enrichment, exercise, social interaction, disease, and age. Gonçalves explains how adult neurogenesis and microglia help support the brain’s ability to encode information, and how disruptions in these systems can affect memory. He also shows that aging and systemic inflammation can weaken spatial encoding while still revealing signs of adaptation and recovery over time. By connecting brain plasticity, immune activity, and memory formation, Gonçalves presents a broader view of how cognition changes across the lifespan and how these mechanisms may inform future strategies for addressing cognitive decline Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40848]
Alpha Clinics in California accelerate the development of regenerative medicine therapies that use cells and genes to treat serious diseases. Patient advocate Tara Radcliffe Ghiglieri shares lived experience with gene therapy, while Sheldon Morris, M.D., M.P.H., Mehrdad Abedi, M.D., Daniela A. Bota, M.D., Ph.D., Catriona Jamieson, M.D., Ph.D., Michael Lewis, M.D., Mark Walters, M.D., and Leo D. Wang, M.D., Ph.D., describe how Alpha Clinic teams design and deliver clinical trials for a wide range of conditions, including cancer, blood disorders, neurologic disease, osteoarthritis, metabolic disorders, pulmonary arterial hypertension, and Duchenne muscular dystrophy. They highlight how coordinated networks, community partnerships, and genomic tools help expand access, lower financial barriers, and bring promising cell and gene therapies to more patients while carefully tracking safety, effectiveness, and long-term outcomes. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 41168]
Off-the-shelf immune cell therapies using engineered T cells represent an important direction in cancer treatment. Lili Yang, Ph.D., at UCLA develops an off-the-shelf platform based on invariant natural killer T (iNKT) cells generated from hematopoietic stem cells, often sourced from cord blood. Yang programs these stem cells with iNKT cell receptors, chimeric antigen receptors (CARs), and genes such as IL-15 to create pure, expandable iNKT products that recognize lipid antigens presented by non polymorphic CD1d molecules. These cells combine multiple killing mechanisms, infiltrate tissues, target tumor cells and immunosuppressive myeloid cells, and show reduced risk of graft versus host disease and cytokine release syndrome in preclinical models. Yang’s group tests this strategy in models of blood cancers and solid tumors, aiming to generate many therapeutic doses from a single donor. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 40846]
RNA binding proteins help cells control how genetic information becomes working proteins, and Gene Yeo, Ph.D., M.B.A., at UC San Diego investigates how their disruption contributes to neurodegenerative disease. Yeo focuses on ALS, a severe motor neuron disease in which the RNA binding protein TDP-43 moves from the nucleus to the cytoplasm, loses normal RNA processing functions, and triggers cryptic exons that damage key neuronal genes, including one linked to motor neuropathy. His group maps these RNA changes and develops small nuclear RNA guides packaged in AAV vectors to block harmful splice sites and restore healthy RNA and protein levels. In cell cultures and a humanized mouse model, this strategy improves axon growth and supports the idea that multiplexed RNA-targeted therapies could correct multiple disease pathways at once. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 41166]
Aging is the leading risk factor for cancer, Alzheimer’s, diabetes, and heart disease, and Robert A.J. Signer, Ph.D., studies how aging stem cells shape pre-cancer and healthspan. As deputy director of the Sanford Stem Cell Discovery Center, Signer focuses on rare blood-forming stem cells that self-renew, generate all blood and immune cells, and normally sustain more than 35 trillion blood cells, including about 2 million new red blood cells every second. His group finds that these “Zen” stem cells slow protein production to limit damaging “trash,” but aging stresses overwhelm these defenses. Stress response programs such as HSF1 then help both healthy and mutant stem cells, fueling clonal hematopoiesis, a common, untreated pre-cancerous condition linked to cardiovascular disease, inflammation, cancer, and increased mortality. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 41253]
Stem cell science is reshaping treatment for complex disorders of the brain and spinal cord. Researchers develop cell based therapies to replace lost dopaminergic neurons in Parkinson’s disease, fill gaps across spinal cord injuries, and calm seizure networks in refractory epilepsy by restoring the balance of inhibition and excitation. Teams test immune cell therapies against Epstein Barr virus infected B cells in multiple sclerosis and collaborate to move treatments across the blood brain barrier to reach diseased cells. Clinicians combine imaging in the operating room, surgical tools, and research on biological age and the pace of aging to understand disease and guide treatment. Patient advocates describe challenges and hopes for better options, and contemporary art reflects on perception in digital and physical worlds. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40992]
Alejandro Sánchez Alvarado, Ph.D., argues that real progress in understanding regeneration comes from studying whole organisms rather than cells grown under artificial conditions. Sánchez Alvarado shows how observations from intact animals reveal organizing rules that narrow laboratory systems can miss. He presents evidence that stem cells in a studied animal lack detectable junctions with neighboring cells and instead respond to signals that travel across tissues. Sánchez Alvarado links this communication to extracellular vesicles that carry RNA and to metabolic support involving creatine, highlighting how distant tissues influence repair. Using imaging and molecular analyses, he tracks how signals move through the body and how specific cell populations change state during recovery. Sánchez Alvarado concludes that broad, comparative research is essential for uncovering general principles that govern how adult tissues restore form and function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40454]
An in vivo brain organoid platform reveals how human neurons and glia interact across development, aging, and disease. Fred H. Gage, Ph.D., generates three dimensional organoids from induced pluripotent stem cells and examines their maturation, synapses, and network activity with two-photon imaging and single-cell profiling. Gage integrates human microglia and astrocytes to study immune signaling, injury responses, and support functions that shape circuit behavior. Transplantation enables vascularization, reduces cell death, and yields features consistent with a blood brain barrier. Analyses identify diverse astrocyte types and trajectories, while patterns of tau expression inform Alzheimer’s disease modeling. Gage also converts adult fibroblasts into age retaining neurons that assemble into 3D spheroids, creating complementary models to connect genes, cells, and circuits with pathology and to guide strategies for prevention and therapy. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41160]
Clinical trials turn scientific discoveries into real options for patients and volunteers, advancing care while safeguarding participants. Sheldon Morris, M.D., M.P.H., explains how independent oversight, core ethical principles, and stepwise phases evaluate safety and benefit, and clarifies participants’ rights and responsibilities. Sandip Patel, M.D., F.A.S.C.O., highlights how carefully designed studies open access to promising cell and gene-based approaches while balancing risks and benefits. Robert A.J. Signer, Ph.D., underscores why participation—including consenting to share samples and data—helps researchers understand disease and accelerate better treatments. Morris, Patel, and Signer point audiences to practical ways to locate studies through registries and national databases, discuss what costs are typically covered, and advise asking questions about study design and safety. They also caution against unproven “stem cell tourism” and emphasize informed decisions. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40438]
Marisa Korody, Ph.D., leads groundbreaking work at the San Diego Zoo Wildlife Alliance’s Beckman Center for Conservation Research, where scientists use advanced genetic and stem cell technologies to protect endangered species. Korody highlights efforts to save the critically endangered northern white rhino by developing induced pluripotent stem cells that can be transformed into egg and sperm precursors, offering a potential path to revive the species. This research is part of a broader conservation mission that includes global projects in genetics, reintroduction, and community engagement. By combining cutting-edge science with wildlife management, the San Diego Zoo Wildlife Alliance works to preserve biodiversity and ensure the survival of species threatened by habitat loss, poaching, and climate change, demonstrating the critical role of innovation in conservation. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40451]
Advances in precision medicine and patient advocacy are transforming the way cancer is understood and treated. Nikoo McGoldrick shares her personal journey with metastatic breast cancer, emphasizing the importance of patients having a voice in their care. Sheldon Morris, M.D., M.P.H., explains how regenerative medicine progresses through stem cell therapies, gene therapies, CAR-T cell treatments, and small molecules, with clinical trials addressing cancer, autoimmune disorders, and neurological diseases. Sandip Patel, M.D., F.A.S.C.O., highlights cancer stem cells as key drivers of relapse and resistance, describing precision medicine approaches, novel CAR-T therapies, and the role of artificial intelligence in cancer detection and treatment. Rebecca Shatsky, M.D., focuses on breast cancer as a systemic disease linked to dormant cancer stem cells, underscoring the need for genomic and immune-based therapies, including innovative antibody treatments and targeted clinical trials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40910]
Scott A. Armstrong, M.D., Ph.D., of the Dana-Farber Cancer Institute, studies how certain aggressive forms of acute myeloid leukemia (AML) develop and survive. His work centers on a protein called menin, which helps leukemia cells keep cancer-promoting genes switched on. Armstrong’s team has found that blocking menin with specially designed drugs can shut down these gene programs, push leukemia cells to mature, and slow or stop the disease in lab models and patients. While some leukemias adapt by developing mutations in menin or finding other ways to survive, his research is revealing why certain genes are especially dependent on menin and how to target them more effectively. These discoveries are now shaping new treatments, drug combinations, and potential strategies for other cancers that rely on similar mechanisms. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40875]
Sean Morrison, Ph.D., from the Children’s Medical Center Research Institute at UT Southwestern, investigates how stem cells function, regenerate, and interact with their surrounding environment in the bone marrow. His research reveals how leptin receptor-positive cells—key components of the bone marrow niche—regulate hematopoietic stem cell maintenance and regeneration, influence platelet production, and respond to physiological stress like pregnancy. Morrison uncovers a reciprocal relationship between these niche cells and peripheral nerves, showing that disrupting nerve signals impairs bone marrow recovery after chemotherapy or radiation. His work also links retrotransposon activation during pregnancy to increased red blood cell production, with implications for maternal health and transplant medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40449]
Deepak Srivastava, MD, explores how cellular reprogramming offers new hope for treating heart disease. He highlights innovative strategies to regenerate damaged heart tissue by stimulating adult cardiomyocytes to divide and converting fibroblasts into heart-like cells. His team develops a nonviral delivery system using lipid nanoparticles and investigates the role of specific gene regulators in restoring heart function in animal models. Srivastava also discusses a potential oral therapy for aortic valve disease, driven by insights into cellular fate changes caused by NOTCH1 mutations and telomere shortening. Additionally, he reveals how trisomy 21 may trigger congenital heart defects by altering the identity of specialized heart cells. Through pioneering research in genetics and regenerative medicine, Srivastava demonstrates how understanding developmental biology can lead to transformative clinical advances. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40447]
Hear about cutting-edge advances in regenerative medicine, from lab breakthroughs to patient impact. Catriona Jamieson, MD, PhD, introduces efforts at the Sanford Stem Cell Institute to develop therapies that enhance the body’s ability to heal itself. Dan Kaufman, MD, PhD, shares progress in cancer immunotherapy using engineered natural killer cells derived from pluripotent stem cells. Karen Christman, PhD, explains how her team creates injectable hydrogels from pig heart tissue to support heart repair and regeneration after a heart attack. Tiffani Manolis highlights industry support for making cell and gene therapies more accessible. Patient advocate Justin Graves describes his life-changing experience receiving a stem cell-based therapy for epilepsy, underscoring the real-world promise of these innovations. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40705]
AI and genetic medicine are converging to transform how we diagnose, treat, and prevent disease. Gene Yeo, Ph.D., unites RNA biology with artificial intelligence to speed the path from genome sequencing to personalized RNA therapeutics. Advances in sequencing have reduced costs dramatically, making interpretation and translation into treatments the real challenge. Using deep learning and large datasets of RNA-binding proteins, Yeo predicts disease vulnerabilities and identifies therapeutic targets, including in neurodegeneration and muscular diseases. Alexis Komor, Ph.D., focuses on DNA, explaining human genetic variation—particularly single-nucleotide variants—and how genome editing technologies like CRISPR can target them. She highlights strategies to correct harmful mutations and explores precise, programmable interventions. Together, their research drives discovery and enables more effective, personalized therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40459]
As. Warshaw draws on her experience in global biotech and healthcare communications, while Signer shares real-world lessons from academic science and public engagement. Together, they highlight how clarity and creativity can elevate a researcher’s voice, build trust with diverse audiences, and drive impact across fields. The session is filled with actionable insights for scientists aiming to connect their work with the world. Series: "Stem Cell Channel" [Humanities] [Science] [Show ID: 40460]
UCLA’s Avishek Adhikari, PhD, presents new research on the role of GABAergic neurons in the brain’s periaqueductal gray (PAG) region. Previously studied for their involvement in fear and defensive behaviors, these neurons were found to promote food-seeking behavior when activated—even in fully fed mice. Using calcium imaging and optogenetics, Adhikari’s team discovered that these neurons are active during food approach but suppressed during eating. The effect is stronger for high-value foods like chocolate or crickets and depends on the mouse’s prior experience with that food. A key finding is that these neurons influence behavior through a specific projection to the zona incerta, a subthalamic region. Rather than signaling hunger, this pathway appears to drive food seeking based on reward value, highlighting a new motivational circuit in the brain. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40444]
William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]
The 3rd Annual Global Astrobiotechnology Hub focuses on advancing the intersection of space exploration, biotechnology, and innovation. The program brings together scientists, researchers, and space professionals to discuss how space technologies can accelerate scientific breakthroughs, particularly in fields like personalized medicine and bioengineering. Key themes include the challenges of conducting real-time research in space, the need for specialized astronaut-scientists, and the potential of space for groundbreaking experiments, such as organoid growth and in-space manufacturing. Experts underscore the importance of public access to scientific data and highlight the role of new media in engaging the public with space research. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40389]
Scientists, leaders, and patients discuss the intersection of cutting-edge science and real-world impact. They explore the importance of patient perspectives in shaping medical advancements and how collaboration fuels groundbreaking research. Key scientific achievements in areas like regenerative medicine, cancer therapies, and space biology are highlighted. The group emphasizes the need for scientists to engage more with the public—through social media and media appearances—to help people understand and value the life-changing discoveries in science.Featuring:Catriona Jamieson, M.D., Ph.D.UC San DiegoSandra DillonPatient AdvocateAlexander Khalessi, M.D., M.B.A.UC San DiegoJana StoudemireCelestial Strategy, LLCAlysson Muotri, Ph.D.UC San DiegoRebecca MooresPhilanthropist and Patient Advocate Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40519]
Karen Christman, Sheila Chari, Stella Hurtley, and Robert Stephenson explore academic publishing in stem cell research, focusing on reproducibility, collaboration, and public communication. Editors from top journals discuss curating impactful research, sharing clinical trial data, and addressing challenges in scaling and standardizing therapies. They emphasize bridging silos, advancing precision regenerative medicine, and navigating open access publishing to responsibly propel the field forward. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39940]
Learn about advancements in precision medicine, particularly the role of AI, stem cell research, and gene therapy. Experts highlight AI’s potential in personalized treatments, diagnostics, and patient care. Key topics include RNA targeting therapies, base editing for gene mutations, and using stem cells for disease modeling and regeneration. AI’s contribution to enhancing healthcare efficiency and decision-making is also explored, emphasizing its role in personalized medicine through large data sets. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39981]
Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]
Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A., discuss exciting advancements in brain cancer research, focusing on glioblastoma, an aggressive and challenging tumor. They highlight how specific genetic mutations drive tumor growth and how targeting these mutations could lead to new treatments. They also delve into cutting-edge therapies, including using light to activate drugs aimed at combating cancer. A central theme of the talk is the complexity and ever-changing nature of these tumors, which makes them difficult to treat. However, technological breakthroughs, like single-cell genetic sequencing and lab-grown tumor models, are providing scientists with valuable insights into tumor behavior, paving the way for more personalized and effective treatment options in the future. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39871]
Le Xu, Ph.D., examines the intricate processes underlying lung development and disease, with a focus on idiopathic pulmonary fibrosis (IPF). Xu explores the roles of genetic and cellular mechanisms, including the hedgehog pathway, FGF signaling, and epithelial-mesenchymal interactions, in driving lung fibrosis. Xu also highlights links between congenital diaphragmatic hernia (CDH) and lung development, suggesting that both mechanical and genetic factors contribute to lung hypoplasia. The discussion includes the development of advanced mouse models that replicate key aspects of human IPF, offering insights into fibrosis progression. Xu's research ultimately seeks to identify the causes of lung tissue abnormalities and pave the way for targeted therapies. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39460]
Gloria Yiu, M.D., Ph.D., delves into the transformative potential of genetic editing technologies in addressing rare immune disorders, with a focus on CD3δ severe combined immunodeficiency (SCID)—a condition characterized by impaired T-cell development and severely compromised immune function. Leveraging her expertise as a physician-scientist, Yiu explores how CRISPR and other precision gene-editing tools can correct genetic mutations at the cellular level, potentially restoring T-cell production and immune resilience in patients with CD3δ SCID. Her presentation underscores the challenges and breakthroughs in treating such life-threatening conditions, emphasizing the role of interdisciplinary research, clinical innovation, and ethical considerations in advancing the frontiers of personalized medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40245]
The infections disease landscape is constantly changing - challenging our standard treatments. Can new - as well as ancient - therapies be the answer? Hear from experts on the cutting edge of phage therapy, HIV/AIDS research and cancer care about what is on the horizon to improve human health. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39982]
John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]
Catriona Jamieson, M.D., Ph.D., discusses pioneering research on cancer and aging in space environments, highlighting how microgravity accelerates cancer cell growth and leads to stem cell exhaustion, genomic instability, and “dark genome” activation. Using innovative tools like nano-bioreactors and artificial intelligence, her team simulates these effects and tracks cellular changes, uncovering how space’s unique conditions drive mutations and alter cellular behavior. They find that stem cells rapidly proliferate but then become exhausted in space, a process tied to telomere shortening and mitochondrial stress, impacting cell longevity and regenerative potential. Through collaborations with NASA and industry partners, Jamieson’s research aims to develop therapies to counter these effects, offering potential insights for cancer treatment and stem cell health on Earth. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39948]
Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]
Dennis O. Clegg, Ph.D., discusses treatments for age-related macular degeneration (AMD), a condition that causes vision loss. Clegg explains that while patients often report improved vision after receiving implants, objective tests don't always confirm this. He explores the potential differences in patients' responses based on genetics and disease progression. There is also an ongoing challenge in finding the best ways to reduce immune rejection of these treatments. New trials are underway to test implants in earlier stages of the disease, and researchers are looking at different strategies like localized immunosuppression. Additionally, some studies suggest that secretions from retinal cells may help preserve vision. Overall, there are many open questions, but advances in the field offer hope for better AMD treatments. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39459]
Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]
Explore the captivating realm of brain research at UC San Diego with Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A. Furnari and Khalessi delve into groundbreaking efforts to find new treatments for neurological conditions such as brain tumors, stroke, and brain injuries, bringing hope to patients and their families. Emphasizing ethics, innovation, and patient care, Furnari and Khalessi shed light on the challenges and successes in their quest to unravel the mysteries of the mind. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39723]
Catherine Yeung, Pharm.D., Ph.D., M.P.H., discusses groundbreaking advancements in kidney-on-a-chip technology, emphasizing its potential to revolutionize human health. She delves into the role of environmental toxins, such as okra toxin A, microplastics, and plasticizers, in contributing to chronic kidney disease, particularly in regions with specific dietary practices. Yeung also addresses the challenges of replicating adult kidney cells from stem cells, which often retain a fetal phenotype, and underscores the value of stem cell-derived models for genetic manipulation and disease research. Additionally, she highlights the increased risk of kidney stones in astronauts post-spaceflight and the broader implications of organ-on-chip technology for studying therapies and diseases. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39458]
Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body’s natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]
Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]
Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods, emphasizing complex patterning, long-term cultures, and co-culture with mouse brain cells for improved physiological relevance. Microfluidics are utilized for enhanced oxygenation and physiological conditions. Future efforts focus on incorporating microglial cells for synaptic pruning studies and overcoming challenges in cryopreservation. Overall, the research aims to advance understanding of neural mechanisms and diseases, enhancing organoid fidelity for biomedical applications. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39456]
Benjamin Freedman, Ph.D., delves into the creation and functionality of kidney organoids. He discusses their focus on filtration over hormone functions, and answer intriguing questions about urine characterization and the necessity of organoid structures. Freedman explores the use of scaffolds for implants and ponder the philosophical implications of off-target cells in organoids, questioning whether these cells are a natural part of organ development. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39455]
Can we not only live longer but better, healthier lives? Robert A.J. Signer and Shiri Gur-Cohen describe how stem cell research may hold the key to longevity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39869]
Andrew Yoo, Ph.D., provides insight into the ongoing research on neurodegeneration and neuronal reprogramming, highlighting the complexities and challenges in modeling and understanding these processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39454]
Why explore stem cells in space when we have the comfort of Earth's laboratories? Join Robert A.J. Signer, Ph.D., alongside Catriona Jamieson, M.D., Ph.D., and Alysson Muotri, Ph.D., as they delve into the untapped potential of space experiments for expediting medical breakthroughs. Patient advocate Alexandria Allen offers a poignant narrative, revealing the profound impact such research has had on her personal health journey. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39733]
Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39453]
Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]
Marking the one-year anniversary of the Global Astrobiotechnology Hub, an esteemed panel convenes to envision the future of space exploration and stem cell research. Central to their discussion is the imperative to enhance accessibility and expedite scientific inquiry in space. They advocate for a shift towards establishing regular access to space, enabling frequent dispatches of payloads and experiments. They highlight the pressing need to advance technology to democratize space research, opening doors for nontraditional researchers from industry, academia, and beyond. They emphasize the significance of scientist-astronauts who possess a nuanced understanding of research methodologies. Emphasizing the importance of public engagement, they underscore the need to disseminate research findings widely and mentor the upcoming generation of scientists. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39528]
Elena Ezhkova, Ph.D., discusses the role of Merkel cells in touch sensation and their connection to nerves. She shares research on skin cancer formation, focusing on the PRC1 complex's impact on gene expression. Ezhkova also investigates epithelial-to-mesenchymal transition (EMT), finding it contributes to cancer spread. Ezhkova offers insights for potential cancer treatments. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38335]
Amander Clark, Ph.D., delves into crafting artificial ovaries for fertility and aging research. She stresses the importance of diversity in stem cell studies to ensure comprehensive findings. By assembling ovarian models from various genetic backgrounds, her team aims for inclusive representation in biomedical research, potentially offering insights into reproductive health and disease. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38334]
Hanna Mikkola, M.D., Ph.D., shares her work in hematopoietic stem cells (HSCs) and their complex renewal process. Her research aims to unravel these cells' behavior in mice and humans, offering potential insights for future medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39258]
Mathew Blurton-Jones presents CRISPR-based interventions for a rare brain disorder in mice by substituting defective brain cells with healthy ones. He details experiments demonstrating the efficacy of corrected cells in mitigating brain pathologies. Blurton-Jones emphasizes the need for cautious translation to human trials, advocating gradual cell replacement to preempt potential adverse effects. Additionally, he delves into the implications of microglia in Alzheimer's disease progression and explores potential interconnections among various neurodegenerative conditions. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38333]
Anna Beaudin, Ph.D., delves into the intricacies of how prenatal inflammation impacts the immune system's blueprint, shaping its long-term function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39257]
CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. In this fascinating panel, clinic directors discuss advanced treatments, therapies like gene editing, and sharing knowledge and creating networks across the country for better patient care.Featuring:Geoffrey Lomax, Dr.PHCalifornia Institute for Regenerative MedicineEsther and Andrew SchorrPatient AdvocatesSandra DillonCancer Survivor and Stem Cell ChampionCatriona Jamieson, M.D., Ph.D.UC San DiegoMehrdad Abedi, M.D. UC DavisDaniela A. Bota, M.D., Ph.D.UC IrvineSheila Chari, Ph.D.Cell PressLeo D. Wang, M.D., Ph.D.City of Hope National Medical CenterMark Walters, M.D.University of California, San FranciscoThomas Buchanan, M.D.University of Southern CaliforniaMichael Lewis, M.D.Cedars SinaiNoah Federman, M.D.UCLA Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39070]
Experts discuss the immense potential of conducting experiments and manufacturing goods in space. They explore how this could enhance our understanding of health issues, unveil new discoveries, and produce innovative technology for use on Earth. The conversation encompasses collaborations between various industries and scientists, aiming to explore the distinct conditions in space to enhance life for all.Featuring:Catriona Jamieson, M.D., Ph.D.UC San DiegoJana Stoudemire, M.Bio.Axiom SpaceAlain Berinstain, Ph.D.Space TangoMarc Giulianotti, Ph.D.Sierra SpaceKevin Engelbert, M.S.F.NASAMichael Roberts, Ph.D.CASISArun Sharma, Ph.D.Cedars Sinai Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39072]
Clive Svendsen, Ph.D., leads groundbreaking experiments using stem cell transplants, uncovering unexpected findings. These trials aimed at improving ALS treatments, revealed higher success with upper motor neuron transplants compared to spinal cord methods. Svendsen's exploration of cortical transplants hints at a potential breakthrough. Moreover, his study of stem cell behavior in space opens doors to exciting medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39068]
Hans Clevers, M.D., Ph.D., shares his research at the intersection of medicine and biology. Clevers discusses revolutionary advances in personalized medicine, where patient-specific treatments can be developed by studying small samples of patients' tissues. He explores the role of specialized cells known as "best for cells" in gastrointestinal health, shedding light on how they may help fight infections. Additionally, he highlights how mini-organs, or organoids, grown in the lab help us understand complex cellular functions and diseases. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39066]
Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]
Siddhartha Jaiswal, M.D., Ph.D., discusses clonal hematopoiesis and its impact on aging and diseases. Jaiswal highlights the role of genetic variations, focusing on a specific gene, TET2, and its link to clonal expansion. He explains that certain genetic variations can slow clonal expansion, potentially offering insights into treatments or interventions to mitigate its effects. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39260]
Astronaut Peggy Whitson, Ph.D., and Lisa Carnell, Ph.D., discuss various aspects of space exploration, life in microgravity, and the future of space science and research. They delve into the challenges astronauts face, from taste differences in space to innovative 3D printing solutions. The conversation also highlights the importance of stem cell research, personalized medicine, and drug development in space. Whitson's unique perspective offers insights into the awe-inspiring views of Earth from space and the collective responsibility to protect our planet. This thought-provoking discussion exemplifies the intersection of science, space exploration, and the promise of a future beyond our planet. Series: "Stem Cell Channel" [Science] [Show ID: 39073]
Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TERT, which, when administered to mice, reverses age-related changes. It restores cognitive function, reduces amyloid plaque, and alleviates inflammation. This suggests that maintaining TERT levels can counteract age-related cognitive decline and neurodegeneration, offering potential for treating neurodegenerative diseases like Alzheimer's. DePinho's work expands our understanding of telomerase's multifaceted role in aging and neurodegeneration, holding promise for interventions against these age-related processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39071]
Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular barcoding and single-cell RNA sequencing, he unveils a potential therapeutic target which may offer promising insights into treating leukemia by disrupting the stromal activities that support it. Zon showcases the power of zebrafish models in advancing our understanding of hematopoiesis and cancer, promising new avenues for research and treatment. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39064]
Are you curious about the future of medical treatments and how they might impact your health? Malcolm Moos, Jr., M.D., Ph.D., shares how cellular therapies are revolutionizing medical treatments. Explore how cells hold the potential to provide new hope for individuals facing various health challenges. Delve into the concept of personalized medicine, discover how regulatory agencies are safeguarding patients' well-being, learn the science behind cell behavior and genetics, and how these processes influence innovative medical treatments and so much more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38330]
Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]
Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]
Joseph C. Wu, M.D., Ph.D., shares his pioneering research on cardiovascular disease mechanisms using patient-specific stem cells. Learn about accelerated drug discovery, "clinical trials in a dish," and precision medicine's impact on treatment. Explore genomics, stem cells, imaging, and more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38327]
Elsy Buitrago-Delgado, Ph.D., shares how spatial analysis of RNA distribution during early mouse embryogenesis suggests that the first cell fate choice is made at the 4-cell stage. She also discusses how notch signaling regulates cell fate choices during early human development. Series: "Stem Cell Channel" [Science] [Show ID: 38888]
Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]
Over 65 million people around the globe are affected by epilepsy. Jenny Hsieh's research explores the underlying causes and mechanisms of epilepsies. Using stem cell-based models, including patient-derived neurons, she investigates how genetic and environmental factors contribute to the development of these conditions and potential therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38326]
While exercise helps us stay healthy, what is happening on the molecular level? Matthew A. Romero, Ph.D., shares his work to understand how muscle in general and other cells specifically are transcriptionally regulated by exercise and how this affects their general behavior and how this is impacted by diseases such as obesity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39033]
Gaia Navarino shares her work on disorder-causing genetic mutations at the system, cellular and molecular level. With a focus on autism spectrum disorder, she explains techniques used to identify common pathophysiological mechanisms in ASD and how that could provide a framework for the development of effective pharmacological therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38325]
Ali H. Brinvanlou, Ph.D., shares his work using in vitro attached human embryos and genome-edited synthetic embryos derived from human embryonic stem cells to learn the molecular, cellular, and embryological basis of early human development. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38324]
Have questions about publishing in academic journals? Sheila Chari, Ph.D., editor in chief of Cell Stem Cell, explains the process from pre-submission through publication. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38722]
Tim Fenton, Ph.D., University of Southampton, shares his work on the roles of APOBEC3 genes. Hear how he is investigating APOBEC regulation and function in keratinocytes. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38724]
How do visions and norms of scientific progress inform, encourage or constrain democratic governance of science? How do questions of warrant, purpose, and benefit get asked and answered? Andy Murray, Ph.D., sits down with Carrie Wolinetz, Ph.D., National Institutes of Health (NIH), Maria Millan, M.D, California Institute for Regenerative Medicine (CIRM, Derek Thompson, The Atlantic, and Sheila Jasanoff, J.D., Ph.D., Harvard University, to explore these questions and more. Series: "Stem Cell Channel" [Science] [Show ID: 38731]
How do we set practical policies that allow scientific discovery to thrive while keeping an eye to risks and benefits for all? Carrie Wolinetz, Ph.D.,National Institutes of Health (NIH), looks at current and past policy and shares her insights on the democratic governance of science. Series: "Stem Cell Channel" [Science] [Show ID: 38745]
How do structures and practices of privatization and commercialization affect capacities for deliberating and defining limits? How do questions of purpose, desirability, and public good relate to the prioritization of commercialization and profit? What means, formal and informal, exist for setting limits or seeking alignment between public and private interests? Krishanu Saha, Ph.D, Rosemarie Garland-Thomson, Ph.D., Reuven Brandt, Ph.D., and J. Benjamin Hurlbut, Ph.D., engage in a lively discussion of cosmopolitan ethics. Series: "Stem Cell Channel" [Public Affairs] [Humanities] [Show ID: 38730]
How do research communities contend with controversial science? J. Benjamin Hurlbut, Ph.D., Arizona State University, Alysson Muotri, Ph.D., UC San Diego, Matthew Porteus, M.D., Ph.D., Stanford University, and Jacob (Yaqub) Hanna, M.D., Ph.D., Weizmann Institute of Science, explore controversial case studies and the limitations of scientific deliberation/dissent/ambivalence. Series: "Stem Cell Channel" [Health and Medicine] [Humanities] [Science] [Show ID: 38729]
The identity of somatic and pluripotent cells can be epigenetically reprogrammed and forced to adapt a new functional cell state by different methods and distinct combinations of exogenous factors. The aspiration to utilize such in vitro reprogrammed pluripotent and somatic cells for therapeutic purposes necessitates understanding of the mechanisms of reprogramming and differentiation and elucidating the extent of equivalence of the in vitro derived cells to their in vivo counterparts. Jacob (Yaqub) Hanna, M.D., Ph.D., presents his group’s recent advances toward understanding these fundamental questions and further details ongoing efforts to generate developmentally unrestricted human naive pluripotent cells with embryonic and extra-embryonic developmental potential. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38323]
Systems neuroscience aims to understand how brain cells and circuits are organized to produce behavior in living organisms. Julio Martinez-Trujillo, M.D., Ph.D., shares his research studying how neurons interact with one another and other cell types within a circuit during ex vivo and in vivo conditions. He also looks to the future and discusses how stem cell technologies can provide unique access to study human circuits and new insights into the nervous system. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38322]
As a mechanical engineer, Jin-Hyung Shim, Ph.D. has a unique perspective on tissue and organ regeneration. He discusses the present and potential of 3D printed biomaterials. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38321]
Shiri Gur-Cohen, Ph.D., UC San Diego, explains how her lab studies how epithelial stem cells communicate with their vascular microenvironment to advance regeneration and combat metastatic diseases. Series: "Stem Cell Channel" [Education] [Show ID: 38409]
How can we better understand the earliest stages of human development? Jianping Fu, Ph.D., University of Michigan, discusses his work using stem cell-derived embryoids. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38320]
Alysson Muotri discusses modeling Pitt-Hopkins syndrome (PTHS) using stem cells and brain organoids. He shares how rescuing TCF4 expression with CRISPR-mediated epigenetic induction of AAV vector delivery provides a gateway for targeted therapeutics for PTHS and related conditions. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38516]
Thomas C. Südhof, M.D., Stanford University, discusses facets of the fundamental cell biology of ApoE and APP analyzed in stem cell-derived human neurons. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38405]
The human placenta may hold important clues to the health of both mothers and babies. Mana Parast, M.D., Ph.D., discusses placental development, what we can learn from pathologic evaluation of the placenta after delivery, and modeling the placenta with stem cells. Karen Mestan, M.S., M.D., shares highlights in neonatal medicine, how to use the placenta as a diagnostic tool to improve the immediate and long term health of newborn patients, and what the role of the placenta could be in NICU management. Catherine and Greg Higgins share their experience as parents with twins in the NICU. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37969]
Derrick J. Rossi, Ph.D., President and Chief Executive Officer of Convelo Therapeutics has a long history of pioneering methods to make stem cell–based treatments for disease a reality. He shares stories of science making its way from the lab and into biotech with the intention of improving the lives of patients. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38404]
Frank Furnari, Ph.D., of UC San Diego, shares his work using stem cells as a vehicle to generate models of brain cancer. Focusing on glioblastoma, he explains how tumor avatars could lead to new therapies. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38514]
Jeffrey Magee, M.D., Ph.D., of Washington University in St. Louis, discusses how mechanisms that regulate hematopoietic stem cells change with age and how this shapes the biology of pediatric leukemia. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38398]
CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. Sandra Dillon shares how their work has impacted treatments for her rare cancer. Maria T. Millan, M.D., Mehrdad Abedi, M.D., Daniela A. Bota, M.D., Ph.D., Sheila Chari, Ph.D., Noah Federman, M.D., Catriona Jamieson, M.D., Ph.D., Sean Turbeville, Ph.D., and Leo D. Wang, M.D., Ph.D., discuss current clinical trials and the future of stem cell research. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38400]
How do epithelial stem cells enable renewal and regeneration of organs in adults? Ophir Klein, M.D., Ph.D., explains his research in stem cell-fueled tooth renewal and intestinal stem cells. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38318]
What if we could trick stem cells into thinking they were young again? What would the impact be on human health and aging? Shiri Gur-Cohen, Ph.D., shares her work. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38216]
What challenges does aging pose to both individuals and society at large? What causes aging at the cellular and molecular level? Stem cell research is be key to finding solutions that increase our healthspan and change how we think about aging. Robert A.J. Signer, Ph.D., shares what is on the horizon. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38215]
Su-Chun Zhang, M.D., Ph.D., shares how neural transplantation cell therapies can be used to treat neurological conditions such as Parkinson's disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38203]
Can we leverage stem cells to help live longer, healthier lives? Robert A.J. Signer, Ph.D., and Shiri Gur-Cohen, Ph.D., examine the process of aging at the molecular and cellular level to show how stem cells may be the key to preventing age-related health problems. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37968]
Thorold Theunissen, Ph.D., of the Washington University School of Medicine in St. Louis shares his work using naive stem cells to model trophoblast development, Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37674]
Dilek Colak, PhD, shares the results of recent work identifying aberrant Ca2+ signaling in ASD astrocytes as a mechanism that contributes to specific behavioral and neuronal deficits. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37673]
Nicolas Rivron, PhD, shares his lab's work to better understand healthy embryo development. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37672]
Michele De Luca, MD, shares his research in gene therapy for epidermolysis bullosa and cell therapy for ocular burns. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37671]
A model of human cortical development could be used to instruct novel computational learning approaches. Alysson Muotri, Phd, Sujeeth Bharadwaj, PhD, Weiwei Yang, and Gabrial Silva, MSc, PhD, discuss the promise, the problems, and the potential when biology and artificial intelligence meet. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37556]
Don Cleveland, PhD, shares new research on the role of chromothripsis, targeting cancers driven by ecDNA and more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37586]
Dan Kaufman, MD, PhD, David Traver, PhD, Gene Yeo, PhD, MBA, discuss the impact of genomics in relation to stell cell research including potential therapeutics for MDS and the role of the somite in hematopoietic stem cell fate. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37561]
There are at least 2,500 proteins that bind RNA. Gene Yeo, PhD, MBA, explains how his lab studies these RNA binding proteins and their impact on human health. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37589]
How can electronic medical records be used to improve patient care and outcomes? Epic Systems Judy Faulkner explains how data systems are being used to analyze trends in healthcare, COVID-19 protocols, cancer rates and more. Series: "Stem Cell Channel" [Science] [Show ID: 37563]
How are stem cells being used in regenerative medicine? Adam Engler, PhD, Sharon Gerecht, PhD, Laura Niklason, MD, PhD, and Jordan Miller, PhD, explain the promising research as well as the challenges. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37555]
Erik Viirre, MD, PhD, Christopher Mason, PhD, Jana Stoudemire, and Brinda Rana, MD, discuss how what we learn from space flight could impact terrestrial health as well as the health of future astronauts. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37559]
How can we improve the number of years we can live healthy lives? Jennifer Trowbridge, PhD, shares her recent work looking at hematopoietic stem cell aging. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37590]
How are hematopoietic stem cells born during the development of the vertebrate embryo? David Traver, PhD explains his work with zebrafish to understand these processes and the role of the somite in instruction of these cells. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37588]
If we can build living tissue whose form is patterned off natural organs, will it have the same function? Jordan Miller, PhD discusses the design space of engineered living tissues and the challenges presented. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37581]
Using a global collaboration established to find antibodies to fight Ebola, scientists have joined together to discover treatments for COVID-19. Erica Ollmann Saphire, Phd, of the La Jolla Institute for Immunology, shares how this collaboration, known as CoVIC, furthers science and public health while creating a template for rapid discovery. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37669]
Sharon Gerecht, PhD, explains how the microenvironment regulates vascular fate in assembly. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37579]
What are the obstacles that stand between us and engineering functional lungs? Laura Niklason, MD, PhD outline the promises and challenges of lung regeneration. She details current studies that may unveil a roadmap for building functional lung aveolus. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37580]
Alpha Stem Cell Clinics is a network of clinics providing stem cell clinical trials to patients. Directors of these clinics throughout the state of California share what the future of these trials looks like, what the future holds for alpha clinics, funding for research, and patient impacts. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37560]
Elly Tanaka of the Research Institute of Molecular Pathology (IMP), Vienna Biocenter shares her work defining what it means to have successful regeneration and studying examples of lack of regeneration and what that means at the cellular and molecular levels. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37019]
Understanding the evolutionary path and the tradeoffs of the modern human brain will likely illuminate the origins of human disease. Alysson Muotri explains his research using stem cells to model Neanderthal brains in an effort to better understand our origins as well as our future. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37018]
Dr. Elisseeff is a leading expert in the field of tissue engineering. She directs the Translational Tissue Engineering Center where she and her team of scientists study stem cells, develop new biomaterials, and design new technologies for regenerative medicine. The goal of her lab is to engineer technologies to repair lost tissues. Specifically, Elisseeff's lab examines hydrogels as a scaffold for tissue engineering. Hydrogels are ideal due to their high water content for nutrient and waste transport, and their ability to encapsulate cells and to implant in a minimally invasive manner. The lab is currently focused on developing synthetic-biological hydrogels with highly controlled physical properties and biological function. The discovery of human embryonic stem cells has created the possibility to regenerate any tissue from a single, totipotent cell population. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Education] [Show ID: 37017]
Scott Lippman, MD, Ludmil Alexandrov, PhD, and Hannah Carter, PhD discuss the genetic, lifestyle-related, and environmental risk factors identified in cancer prevention. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37281]
Chuck Murry, MD, PhD shares recent research on using cardiomyocytes to model COVID-19 heart disease. He also discusses current efforts to regenerate the heart and reduce arrhythmias. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37016]
Connie Eaves, PhD presents her research and examines this moment in time in stem cell biology. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37015]
Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]
Mark Tuszynski, MD, Ph.D., Bob Yant, and Lawrence S.B. Goldstein, Ph.D. discuss the newest research and treatments for spinal cord injury, including how neural stem cells may be leveraged to potentially regain function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 37102]
Karen Christman and Marianna Alperin discuss the newest discoveries and cutting-edge techniques for pro-regenerative biomaterials for heart and skeletal muscle with applications to cardiovascular disease and pelvic floor disorders. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36848]
Davey Smith, MD, Sheldon Morris MD, MPH, and Robert "Chip" Schooley, MD discuss the newest research on COVID-19 including the lessons that can be learned, antivirals, and how to interpret the data. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 37068]
Lorenz Studer, MD. Director, Center for Stem Cell Biology, Sloan Kettering Institute, presents his research. The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine. Series: "Autism Programs for Medical Professionals" [Health and Medicine] [Science] [Show ID: 37009]
Madeline Lancaster, PhD presents her paper as published in the July 10, 2020 issue of Science. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36720]
Stem cell research is changing the way Alzheimer's disease is diagnosed and treated. Larry Goldstein, PhD and Doug Galasko, MD join Alysson Muotri, PhD to share the latest findings and what the future may hold. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36805]
Hans Clevers, MD, PhD, presents his paper as published in the February 27, 2020 issue of Nature. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36177]
Hans Clevers, MD, PhD, presents his paper as published in the February 27, 2020 issue of Nature. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36177]
Leslie Crews, PhD, J. Kellogg Parsons, MD, Rana McKay, MD, and Christina Jamieson, PhD discuss the next generation of cancer treatments. They are joined by Lenny Green who shares the story of his cancer treatment. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36547]
Ezra Cohen, M.D. and Judy Varner, Ph.D. discuss the next generation of cancer immunotherapies – drugs that harness the body’s immune system to kill cancer cells. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36137]
Arnold Kriegstein, MD, PhD presents his paper as published in the January 29, 2020 issue of Nature Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 35457]
Charles Kwok Fai Chan presents his paper as published in the August 17, 2020 issue of Nature Medicine: Articular cartilage regeneration by activated skeletal stem cells. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36174]
Stem cells may play a critical role in treating genetic diseases. Hear from experts in the field.
Moderated by Matthew Porteus, MD, PhD, Stanford University Tippi MacKenzie, MD, UC San Francisco: Fetal Therapy for Alpha Thalassemia Major Matthew A. Spear, MD, Poseida Therapeutics: CAR-T Cells: Poseida Therapeutics Stephen Gottschalk, MD, St. Jude Children's Research Hospital: Gene Therapy for X-linked SCID Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36351]
Stephen Gottschalk, MD St. Jude Children's Research Hospital Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36350]
Phuong Ly-Gallagher was only 29 when diagnosed with colorectal cancer. In this compelling interview, she shares her journey from patient to survivor and advocate. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36435]
Stem cells are on the forefront of the fight against rare pediatric diseases. Experts discuss current therapies and future hopes while a father shares his experience getting treatment for his son.
Moderated by Mort Cowan, MD, UC San Francisco Pawash Priyank: Patient Perspective Diana Farmer, MD, FACS, FRCS, UC Davis: Making Miracles Come To Life Through Stem Cells Rosa Bacchetta, MD, Stanford University: Towards a cure for IPEX: engineered-Treg replacement or stem cell gene editing Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36346]
How are stem cells being used to treat cancer and develop future therapies? Hear from patients, physicians and researchers in this engaging panel.
Moderated by Scott Lippman, MD, UC San Diego Sandra Dillon: Patient Perspective Tannishtha Reya, PhD, UC San Diego: Targeting stem cell signals in cancer progression and therapy resistance Robert A.J. Signer, PhD, UC San Diego: Stem cell regulation by the proteostasis network Karen Aboody, MD, City of Hope: Neural Stem Cell Targeted Anti-Cancer Therapies: From Bench to Bedside Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36361]
How are stem cells being used to treat spinal cord injuries? Hear from patients and researchers on innovations and therapies on the horizon.
Moderated by Jane S. Lebkowski, PhD, Patch Technologies Jake Javier: Patient Perspective Mark Tuszynski MD, PhD, UC San Diego: Neural Stem Cells for Spinal Cord Injury Francois Binette, PhD, Lineage Cell Therapeutics: OPC1 for Spinal Cord Injury: Update and Planning Forward Aileen Anderson, PhD, UCI: Human Neural Stem Cell Efficacy and Repair Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36356]
Stem cells may lead the way towards innovative treatments for eye disease. Hear from experts on the latest research.
Moderated by Dennis Clegg, PhD, UC Santa Barbara Kristin MacDonald: Patient Perspective Henry Klassen, MD, PhD, UCI: Retinal Progenitor Cells for Treatment of Retinitis Pigmentosa Theodore Leng, MD, MS, Stanford University: NeuBright, a purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration Sophie Deng, MD, PhD, UCLA: Limbal stem cell therapy Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36327]
The story of how CIRM-funded research helped preserve vision for Rosie Barrero, who was diagnosed with Retinitis Pigmentosa as a child, and faced the prospect of losing her vision as she became a new mother. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36478]
City of Hope's Jianhua Yu describes research into a treatment for COVID-19 utilizing natural killer cells made possible by funding from California's Stem Cell Agency - CIRM. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36463]
City of Hope's Alpha Stem Cell Clinic Director Dr. John Zaia describes research into a treatment for COVID-19 made possible by funding from California's Stem Cell Agency - CIRM. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36464]
The Scripps Research Institute's Stuart Lipton describes research into a treatment for COVID-19 made possible by funding from California's Stem Cell Agency - CIRM. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36466]
A testimonial from Tom Howing, whose stage IV metastatic cancer disappeared after treatment with a CIRM-funded gene-therapy developed by Forty-Seven Pharma. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36480]
Caleb Sizemore describes living with Duchenne Muscular Dystrophy and how a CIRM clinical trial participant has improved his condition. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36473]
An overview of California's Alpha Stem Cell Clinical Network and how it works to develop and deliver the newest, most advanced treatments for patients throughout the state. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36482]
A testimonial from Pawash Priyank whose newborn son Ronnie was cured of SCID, or bubble-baby disease by a treatment developed with CIRM-funded research. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36481]
A profile of the collaborative approach that joins standard care and research by bringing the traditionally separate research and nursing departments together to provide a new standard of care for patients at the City of Hope Alpha Stem Cell Clinic. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36477]
An overview of gene therapy strategies being employed by CIRM-funded researchers to find effective treatment for sickle-cell anemia. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36476]
A short profile of Javier Lepe, a CIRM-funded intern at the UC Irvine Sue and Bill Gross Stem Cell Research Center and how the program is advancing his career. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36475]
The University of California, San Francisco's Dr. Michael Matthay describes research into a treatment for COVID-19 made possible by funding from California's Stem Cell Agency - CIRM. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36465]
Stanford University's Helen Blau describes research into a treatment for COVID-19 made possible by funding from California's Stem Cell Agency - CIRM. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36462]
The UCLA Broad Stem Cell Research Center's Dr. Gay Crooks describes research into a treatment for COVID-19 made possible by funding from California's Stem Cell Agency - CIRM. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36461]
The UCLA Broad Stem Cell Research Center's Dr. Brigitte Gomperts describes research into a treatment for COVID-19 utilizing lung organoids derived from pluripotent stem cells that is made possible by funding from California's Stem Cell Agency - CIRM. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36460]
Karen Aboody, MD City of Hope
Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36360]
Rosa Bacchetta, MD Stanford University Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36345]
The story of how CIRM-supported research conducted by UCLA's Don Kohn pioneered a total cure for SCID, also known as bubble-baby disease, and how he hopes to employ the same gene-therapy strategies to cure sickle-cell anemia. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36479]
A short profile of Cherie Lepe, a CIRM-funded intern at the UC Irvine Sue and Bill Gross Stem Cell Research Center and how the program is advancing her career. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36474]
Michael Pulsipher of the Saban Research Institute at The Children's Hospital Los Angeles describes how he is working to improve the outcomes for treatments using blood or bone marrow transplantation, particularly in pediatric patients. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 36483]
Deborah K. Lieu, PhD UC Davis Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36335]
Ronnie Kashyap was born without an immune system. Even a cold, an inconvenience at for other kids, was considered life threatening for Ronnie. Diagnosed with severe combined immunodeficiency (SCID), he spent the first few months of his life in the hospital while doctors worked to find an effective treatment. Ronnie's father, Pawash Priyank, shares what his family experienced and how the science of stem cells has changed Ronnie's future. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36436]
Jennifer M Puck, MD UC San Francisco Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36329]
What impacts has stem cell research made for blood and immune system disorders? Hear the latest from experts in the field.
Moderated by Crystal Mackall, MD, Stanford University Alysia Vaccaro: Patient Perspective Jennifer M Puck, MD, UC San Francisco: Gene Therapy for Artemis Severe Combined Immunodeficiency (ART-SCID) Donald B. Kohn, MD, UCLA: Hematopoietic Stem Cell Gene Therapy for Primary Immune Deficiencies Mark C. Walters, MD, UCSF Benioff Children's Hospital Oakland: Gene correction in Sickle Cell Disease Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36332]
Lawrence S.B. Goldstein, PhD discusses his career in science and his work to understand the molecular basis of neuronal defects in Alzheimer's Disease. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36338]
Experts are leveraging stem cells to find effective treatments for COVID-19. Hear from from physicians and scientists about what is happening in labs across the country.
Moderated by Daniela A. Bota, MD, PhD, UCI John Zaia, MD, City of Hope: Antibody Use for Treatment or Prevention of COVID-19 Michael Matthay, MD, UC San Francisco: Cellular Therapy for Acute Respiratory Failure -Mesenchymal Stromal Cells Leonid Groysman, MD, UCI Health: United We Stand Albert Wong, MD, Stanford University: Identifying the Peptides that Activate T Cells in COVID-19 Patients
Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36319]
Donald B. Kohn, MD UCLA Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36330]
After a heart attack and triple bypass surgery at age 60, Pat Farrant learned he had an inherited heart condition. He now dedicates his time to raising awareness about heart disease an its warning signs. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36434]
Theodore Leng, MD, MS Stanford University Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36325]
Irving Weissman, MD discusses his pioneering work in stem cell biology with a focus on cells that make up the blood-forming and immune systems. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36362]
Sophie Deng, MD, PhD UCLA Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36326]
Christine Brown, Deputy Director of the T Cell Therapeutics Research Laboratory at Beckman Research Institute of City of Hope explains how CIRM helps to advance cancer therapies at City of Hope. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36307]
Neuro-Oncologist and Clinical Director of the UC Irvine Alpha Stem Cell Clinic, Dr. Daniela Bota, explains the development and promise of tumor-derived vaccines to treat Glioblastoma, a resistant and devastating brain cancer. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36225]
The story of what has driven UC San Diego's Stephanie Cherqui to develop a gene therapy for Cystinosis, a devastating inherited condition. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36222]
Frances Saldana lost her three children to Huntington's disease - a devastating neurodegenerative condition with no cure. Saldana turned grief into action and co-founded HD-CARE, an organization dedicated to advancing Huntington's Disease research and clinical care. In this interview, she shares her story of advocacy and innovation. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36432]
At 28, Sandra Dillon was diagnosed with myelofibrosis, a life-threatening blood disorder that can lead to acute leukemia. After participating in clinical trials and cutting edge treatments, Dillon has a deep appreciation for personalized medicine and genomics. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36357]
Stem cell research is providing hope for new therapies to treat neurodegenerative diseases. Hear from those on the front lines about what is next.
Moderated by Clive Svendsen, PhD, Cedars-Sinai HD Care: Patient Support Perspective Ralph Kern MD MHSc, Brainstorm Cell Therapeutics: NurOwn (autologous MSC-NTF cells) in ALS- phase 3 clinical trial update Jeanne F. Loring, PhD, Aspen Neuroscience: Neuron replacement therapy for Parkinsons disease Leslie Thompson, PhD, UCI: Stem Cell Based Therapy for Huntington's Disease Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36323]
Can we discover new therapies for the heart with stem cells? From finding safer medication to preventing cardiac arrest, experts share the latest in the field of cardiac stem cell research.
Moderated by Anthony DeMaria, MD, UC San Diego Pat Farrant: Patient Perspective Deepak Srivastava, MD, Gladstone Institutes: Cellular Reprogramming Approaches for Heart Disease Mark Mercola, PhD, Stanford University: Induced Pluripotent Stem Cell (iPSC)-derived Cardiomyocytes for Predicting and Removing Drug Cardiotoxicity Deborah K. Lieu, PhD, UC Davis: The quest for pacemaking cardiomyocytes to engineer biopacemakers Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36336]
Experts share perspectives on institutional, state and national efforts to create knowledge networks that accelerate bench top research, clinical trials, and patient access to experimental and approved therapies. A discussion of how best to capture and integrate various datasets to improve understanding of diseases, discovery of novel targets, therapeutic candidates and biomarkers, accelerating clinical development and approval of novel therapies and enhancing patient access and affordability. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36337]
What can we learn about COVID-19 through stem cell research? A panel of experts shares what we know and what may be possible.
Moderated by Evan Snyder, MD, PhD, Sanford-Burnham Medical Research Institute Brigitte Gomperts, MD, UCLA: Using Lung Stem Cells to Study the Effects of Cigarette Smoking on COVID-19 Sandra Leibel, MD MSc, UC San Diego: Addressing disparity in COVID-19 lung disease & therapeutic response using patient-specific hiPSC-derived lung organoids Justin Ichida, PhD, USC: Development of a new drug to prevent coronavirus infection Karen L. Christman, PhD, UC San Diego: Pro-healing biomaterial for treating inflammation Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36343]
Robert A.J. Signer, PhD UC San Diego Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36359]
Dr. Nadine Burke Harris, California's first-ever Surgeon General , is dedicated to changing the way our society deals with the public health crisis of childhood trauma. An overwhelming scientific consensus demonstrates that cumulative adversity, particularly during critical and sensitive developmental periods, is a root cause to some of the most harmful, persistent and expensive health challenges facing our nation. In this keynote address at the 2020 CIRM Grantee Meeting, Dr. Burke Harris explains the science and solutions. Series: "Women in Science" [Health and Medicine] [Show ID: 36328]
Mark C. Walters, MD UCSF Benioff Children's Hospital Oakland Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36331]
Henry Klassen, MD, PhD UCI Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36324]
Tannishtha Reya, PhD UC San Diego Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36358]
An accident left Jake Javier paralyzed from the chest down the day before his high school graduation. Through a clinical trial, Javier received a transplant of 10 million stem cells and regained use of his arms and hands. Javier shares his story of resilience, science, and hope. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36352]
Deepak Srivastava, MD Gladstone Institutes Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36333]
Francois Binette, PhD Lineage Cell Therapeutics Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36354]
Matthew A. Spear, MD Poseida Therapeutics Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36349]
Tippi MacKenzie, MD UC San Francisco Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36348]
Mark Mercola, PhD Stanford University Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36334]
UCLA biomolecular engineer Yvonne Chen explains recent advances her work has made in engineering cellular receptors to better target cancer cells to improve cancer treatments. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36313]
Retinitis Pigmentosa (RP), a genetically inherited disease that affects the photoreceptors at the back of the eye, leads to blindness. Kristin Macdonald was told she had RP at age 31 - a diagnosis that vaulted her into advocacy. She shares her story of living with blindness, participating in clinical trials, and hope for the future. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36433]
Jeanne F. Loring, PhD Aspen Neuroscience Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36321]
Mark Tuszynski MD, PhD UC San Diego Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36353]
Aileen Anderson, PhD UCI Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36355]
Diana Farmer, MD, FACS, FRCS UC Davis Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36344]
Kevin Petrecca, MD, PhD, FRCS(C) presents his paper as published in the July 8, 2020 issue of Nature. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36173]
Karen L. Christman, PhD UC San Diego Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36342]
Sandra Leibel, MD, MSc UC San Diego Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36340]
Brigitte Gomperts, MD UCLA Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 36339]
Justin Ichida, PhD USC Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36341]
Leonid Groysman, MD UCI Health Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36317]
Albert Wong, MD Stanford University Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36318]
Ralph Kern MD MHSc Brainstorm Cell Therapeutics Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36320]
Leslie Thompson, PhD UCI Series: "Women in Science" [Health and Medicine] [Science] [Professional Medical Education] [Show ID: 36322]
In 2012, Alysia Vaccaro's newborn daughter, Evie was diagnosed with Severe Combined Immunodeficiency (SCID). Children with SCID lack a functioning immune system so even a simple cold can be fatal. After hearing about a potential gene therapy developed by Dr. Don Kohn at UCLA, Vaccaro enrolled Evie in a clinical trial. Today, Evie is a thriving 8 year old with a healthy immune system. Vaccaro shares a bit of Evie's journey and the impact that stem cell research has had on their family. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36431]
Michael A. Matthay, MD UC San Francisco
Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 36316]