Peter Attia: Recent Episodes
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Insights as to why so many drug candidates fail to make it through the development pipeline, and how certain strategies might help
The post How can the process of drug development be improved? appeared first on Peter Attia.
“Probably the biggest return on investment the average person can make is to train for roughly half an hour two times a week, Monday and Thursday.” —Mike Israetel
The post #335 ‒ The science of resistance training, building muscle, and anabolic steroid use in bodybuilding | Mike Israetel, Ph.D. appeared first on Peter Attia.
Recent evidence reveals that the combination of liver disease and type 2 diabetes has a multiplicative effect on cardiovascular disease and mortality
The post Compounding effects of multiple metabolic conditions on cardiovascular risk appeared first on Peter Attia.
“Cholesterol is almost certainly the most important molecule in the brain.” —Tom Dayspring
The post #334 – Cardiovascular disease, the number one killer: development, biomarkers, apoB, cholesterol, brain health, and more | Tom Dayspring, M.D. appeared first on Peter Attia.
Recent mouse studies indicate that FDA-approved CGRP blockers might offer a new treatment option for a condition affecting millions
The post Unlocking the potential of migraine medications for endometriosis treatment appeared first on Peter Attia.
“The notion that aging is not malleable, though wrong and provably wrong, is still the overwhelming opinion even of reasonably educated scientists and certainly of the lay public.” ‒ Rich Miller
The post #333 ‒ Longevity roundtable — the science of aging, geroprotective molecules, lifestyle interventions, challenges in research, and more | Steven Austad, Ph.D., Matt Kaeberlein, Ph.D., Richard Miller, M.D., Ph.D. appeared first on Peter Attia.
Even light-intensity exercise can help to improve sleep among those with insomnia
The post Sleepless nights? Try boosting your physical activity level appeared first on Peter Attia.
"As food and beverages undergo more and more processing, it accumulates more and more plastics, probably another argument for limiting processed foods." —Peter Attia
The post #332 – AMA #67: Microplastics, PFAS, and phthalates: understanding health risks and a framework for minimizing exposure and mitigating risk appeared first on Peter Attia.
While randomized controlled trials remain the gold standard, understanding their limitations is crucial for advancing longevity science
The post A nuanced and multifaceted approach to longevity research appeared first on Peter Attia.
Hypertension is often called the “silent killer.” This guide covers how to monitor blood pressure, who’s at highest risk, and how best to manage it.
The post All things blood pressure: from measurement to management appeared first on Peter Attia.
“Sometimes it makes it more universally easy to understand if we think of what kind of sport we do as a function of intensity and duration.” —Olav Aleksander Bu
The post #331 ‒ Optimizing endurance performance: metrics, nutrition, lactate, and more insights from elite performers | Olav Aleksander Bu (Pt. 2) appeared first on Peter Attia.
A recent study highlights the association between blood pressure medications and risk of falls and fall-related injuries, but we can take steps to offset the danger
The post A link between antihypertensive medications and fall risk reminds us to take precautions appeared first on Peter Attia.
"I really believe in bridging education, mental health, and medical. If you want to make an impact on child well-being and health.”‒ Trenna Sutcliffe
The post #330 – Autism, ADHD, and Anxiety: Understanding the rise in autism and a multidisciplinary approach to diagnosis and treatment of each condition in children | Trenna Sutcliffe, M.D. appeared first on Peter Attia.
A spotlight on a few inspirational people doing amazing things in their 80s, 90s, and beyond
The post The endless possibilities of living well in your marginal decade appeared first on Peter Attia.
A special end-of-year newsletter on how you can apply James Clear’s laws of behavior change to a few of the actionable steps we learned about on The Drive in 2024
The post Using “atomic habits” to reach your health goals appeared first on Peter Attia.
Type 2 diabetes in youths, extending organ viability, preventative ovary removal, “dark genome” therapeutics, and vascular impacts on physical decline
The post Research Worth Sharing, December 2024 Edition appeared first on Peter Attia.
In this special episode of The Drive, Peter tackles a wide range of listener questions submitted over the past year. The discussion spans essential topics such as exercise—covering grip strength, traveling workouts, and why Peter doesn’t consider exercise an ideal weight-loss strategy—and the top biomarkers everyone should track. He also explores promising new longevity research,…
The post #329 ‒ Special AMA: Peter on exercise, important labs, building good habits, promising longevity research, and more appeared first on Peter Attia.
Health awareness exists on a spectrum in which both extremes can be damaging to health and well-being
The post When caution becomes concerning: the relationship between health anxiety and mortality appeared first on Peter Attia.
NAD and its precursors – mainly NR and NMN – have garnered attention for numerous purported benefits, but which are supported by evidence?
The post Evaluating NAD and NAD precursors for health and longevity appeared first on Peter Attia.
“There is no discipline of science or engineering for which our magnitude of certainty is so high relative to such poor quality data.” —Peter Attia
The post 328 – AMA #66: Optimizing nutrition for health and longevity: myth of a “best” diet, complexities of nutrition science, and practical steps for building a sustainable diet appeared first on Peter Attia.
A recent study has triggered alarm over the finding that restricting sugar in the first 1000 days of life protects against diabetes and hypertension in later life, but this conclusion hardly constitutes reliable advice
The post A rational look at a sensationalized sugar study appeared first on Peter Attia.
“The US healthcare system in many ways is a story, an optimistic story of well-intended policies that now are questioned based upon the way the expenditures have increased.” —Saum Sutaria
The post #327 – Choices, costs, and challenges in US healthcare: insurance intricacies, drug pricing, economic impacts, and potential reforms | Saum Sutaria, M.D. appeared first on Peter Attia.
A collection of past newsletters on topics including hearing loss prevention, a randomized trial on exercise and lifespan, using a cognitive bias to improve goal achievement, air pollution, and the impact of dietary protein on muscle protein synthesis
The post Oldies-But-Goodies, December 2024 Edition appeared first on Peter Attia.
Several research articles have been circulating in the news, prompting excitement about the supposed ability of the shingles vaccine to prevent cognitive decline, but is there a causal link?
The post Shingles and brain health: an emerging link or healthy user bias? appeared first on Peter Attia.
A recent study reported positive correlations between exercise duration and CAC, but causality – and relevance to risk of cardiovascular events – is not established
The post Calming the concern over exercise duration and coronary artery calcification appeared first on Peter Attia.
Certain areas of the world have been reported as having disproportionately high numbers of centenarians. What explains these patterns, and what – if anything – do they reveal about the “secrets” to long life?
The post What can we learn from “blue zones”? appeared first on Peter Attia.
“I suspect that that will be the challenge of the next decade or two. It'll be less about what is technically possible and more about what is ethically defensible.” —Peter Attia
The post #325 ‒ Peter’s key takeaways on bone health, calorie restriction and energy balance, dopamine and addiction, gene editing, and testosterone therapy safety with a prostate cancer diagnosis | Quarterly Podcast Summary #3 appeared first on Peter Attia.
Humanity may be reaching the limits of lifespan extension that are possible through treatment of chronic disease, but the door is still open for future advances in aging biology itself
The post Radical extension of the human lifespan, science fiction or reality? appeared first on Peter Attia.
“I still believe that a nutritional approach to weight loss without physical activity or exercise prescribed is not a good strategy. We should implement both and try to have people enjoying the exercise.” —Eric Ravussin
The post #324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D. appeared first on Peter Attia.
“One of the promises of gene editing is that it can provide a single treatment that is a cure for the disease.” —Feng Zhang
The post #323 – CRISPR and the future of gene editing: scientific advances, genetic therapies, disease treatment potential, and ethical considerations | Feng Zhang, Ph.D. appeared first on Peter Attia.
A recent meta-analysis of randomized trials assessed the performance of resveratrol in improving various metrics of metabolic health
The post Failure of resveratrol to improve metabolic health is another nail in the coffin for the alleged “anti-aging” compound appeared first on Peter Attia.
“Bone is a ‘use it or lose it’ tissue.” —Belinda Beck
The post #322 – Bone health for life: building strong bones, preventing age-related loss, and reversing osteoporosis with evidence-based exercise | Belinda Beck, Ph.D. appeared first on Peter Attia.
Popular media has circulated news of a study allegedly showing that exercise is preferable to medication as a treatment for anxiety and depression, but is this interpretation justified?
The post Beyond the headlines: evaluating exercise as an equivalent to medication for the treatment of depression and anxiety appeared first on Peter Attia.
“When we do things intentionally that are physically or mentally challenging for us, our body senses injury and up regulates feel good neurotransmitters. . .so we get our dopamine indirectly by paying for it upfront.” —Anna Lembke
The post #321 – Dopamine and addiction: navigating pleasure, pain, and the path to recovery | Anna Lembke, M.D. appeared first on Peter Attia.
Using biofeedback to reach weight loss goals, preventing falls with exercise, the impact of social support on stress eating, and an atlas of data on changes related to muscle aging
The post Research Worth Sharing, October 2024 Edition appeared first on Peter Attia.
"If you're taking these drugs, really, really pay attention to your protein consumption and your resistance training. . .that's obviously going to be an important part of being on the right side of that body composition curve.” — Peter Attia
The post #320 – AMA 64: New insights on GLP-1 agonists (Ozempic, Wegovy, Mounjaro) – efficacy, benefits, risks, and considerations in the rapidly evolving weight-loss drug landscape appeared first on Peter Attia.
A recent study makes use of multi-omics data to establish patterns of human aging, but results have dubious relevance on an individual scale
The post Do humans age in distinct rapid bursts instead of gradually over time? appeared first on Peter Attia.
“In humans, klotho is indeed a longevity gene. More klotho from the gene means longer life, better cognition. Take it away, shorter life, worse cognition.” —Peter Attia
The post #319 ‒ Peter’s key takeaways on liver health, heart rate variability, AI in medicine, klotho, and lactate metabolism | Quarterly Podcast Summary #2 appeared first on Peter Attia.
A new study indicates that HIIT may help delay or even reverse age-related declines in memory and learning, but this exercise modality remains just one aspect of a well-balanced regimen.
The post High-intensity interval training and cognitive function in older adults: promising but limited findings appeared first on Peter Attia.
Forms of cold therapy have been used for generations for a number of alleged health benefits, but which are supported by evidence?
The post Cold therapy: the facts, the myths, and the how-to appeared first on Peter Attia.
“You see all these three things—the speed, heart rate, and power. Then you see how you feel and which zone are you really in.” —Tadej Pogačar
The post #318 ‒ Cycling phenom and Tour de France champion Tadej Pogačar reveals his training strategies, on-bike nutrition, and future aspirations appeared first on Peter Attia.
A proteomics model may provide an alternative method for estimating risk of mortality and chronic disease
The post Could plasma protein levels be a surrogate for VO2 max testing as a measure of cardiorespiratory fitness? appeared first on Peter Attia.
This video clip is from #201 – Deep dive back into Zone 2 with Iñigo San-Millán, Ph.D., originally released on...
The post Is zone 5 training okay to do immediately following zone 2 training? appeared first on Peter Attia.
“One of the most important qualities of a physician is humility, knowing your limits, and having the self-awareness that you could be wrong.” —Marty Makary
The post #317 ‒ Reforming medicine: uncovering blind spots, challenging the norm, and embracing innovation | Marty Makary, M.D., M.P.H. appeared first on Peter Attia.
Challenges to long-held knowledge makes for attention-grabbing headlines, but not necessarily good science. Excuse me while I scream.
The post A study suggesting that exercise does not impact mortality offers little more than click-bait appeared first on Peter Attia.
“Genetic sensitivity to DHT appears far more important than absolute DHT level. But. . .lowering DHT is a very important strategy to either preventing or halting hair loss.” —Peter Attia
The post #316 – AMA #63: A guide for hair loss: causes, treatments, transplants, and sex-specific considerations appeared first on Peter Attia.
A recent study reports impressive results in male and female mice with anti-IL-11 therapy
The post Is interleukin-11 a promising new target for lifespan-extending interventions? appeared first on Peter Attia.
How a new cell-free DNA test stacks up against other available options
The post A new blood test doesn’t change the game for colorectal cancer screening appeared first on Peter Attia.
“I was allowed to go to the precipice, look over the edge, and then allowed to come back." —Sebastian Junger
The post #315 ‒ Life after near-death: a new perspective on living, dying, and the afterlife | Sebastian Junger appeared first on Peter Attia.
A new observational study has reported positive associations between meat intake and type 2 diabetes risk, but let’s repeat: correlation is not causation.
The post Back on the merry-go-round of bad science regarding meat consumption appeared first on Peter Attia.
Zone 2 training is critical for improving and maintaining mitochondrial health and aerobic capacity, so we’ve put together a resource to answer all of your questions about this pillar of exercise and how to get the most out of Zone 2 training.
The post A guide to Zone 2 training: its profound impact on health, detailed training instructions, addressing male and female differences, and more appeared first on Peter Attia.
“I think we really need a radically different public health paradigm.” —David Allison
The post #314 ‒ Rethinking nutrition science: the evolving landscape of obesity treatment, GLP-1 agonists, protein, and the need for higher research standards | David Allison, Ph.D. appeared first on Peter Attia.
A new study reveals that the prevalence of atherosclerosis is alarmingly high among asymptomatic adults classified as “low risk” and underscores the importance of lipid-lowering therapies for avoiding atherosclerosis progression and mortality
The post Coronary atherosclerosis is a silent killer, but we have tools to stop it appeared first on Peter Attia.
"The body responds in pretty significant ways to alterations in protein availability.” —Peter Attia
The post #313 – AMA #62: Protein’s impact on appetite and weight management, and uric acid’s link to disease and how to manage levels appeared first on Peter Attia.
Mainstream media has reported dubious results of a study indicating that the use of multivitamins is not associated with a reduction in mortality risk, but even if this were true, does it really mean they offer no benefit for health?
The post A recent study does little to supplement earlier knowledge on multivitamins and health appeared first on Peter Attia.
“Lactate is not just an innocent bystander. It's a participant in the process of powering muscle, in fact, all cells.” —George Brooks
The post #312 – A masterclass in lactate: Its critical role as metabolic fuel, implications for diseases, and therapeutic potential from cancer to brain health and beyond | George A. Brooks, Ph.D. appeared first on Peter Attia.
A collection of past newsletters on topics including the influence of bias versus noise, problems with vitamin D literature, muscle mass and cognition, the effects of late-night snacking, and a case study in cardiovascular health
The post Oldies-But-Goodies, August 2024 Edition appeared first on Peter Attia.
“I would say three-quarters of the benefits you can get towards a longer life, come solely from pursuing better health.” —Peter Attia
The post #311 ‒ Longevity 101: a foundational guide to Peter’s frameworks for longevity, and understanding CVD, cancer, neurodegenerative disease, nutrition, exercise, sleep, and more appeared first on Peter Attia.
A recent study suggests that use of medications commonly prescribed for ADHD treatment is associated with increased risk of certain cardiovascular conditions, but does it exceed the risks associated with untreated ADHD?
The post Does pharmacological treatment for ADHD increase risk of cardiovascular disease? appeared first on Peter Attia.
“There's no evidence that says exogenous T replacement causes acceleration or propagation of someone's prostate cancer.” —Ted Schaeffer
The post #310 – The relationship between testosterone and prostate cancer, testosterone replacement therapy, and tools for predicting cancer aggressiveness and guiding therapy | Ted Schaeffer, M.D., Ph.D. appeared first on Peter Attia.
A meta-analysis reports that toothbrushing reduced the risk of hospital-acquired pneumonia among ICU patients, hinting at the whole-body impacts of oral hygiene
The post Don’t underestimate the importance of oral health appeared first on Peter Attia.
“What I'm excited about is the opportunity for new businesses and new ways of delivering to patients insights that are data-driven.” —Zak Kohane
The post #309 ‒ AI in medicine: its potential to revolutionize disease prediction, diagnosis, and outcomes, causes for concern in medicine and beyond, and more | Isaac Kohane, M.D., Ph.D. appeared first on Peter Attia.
Most of us have some vices when it comes to optimizing our health and performance, even when we know the potential harm. A recent eye-opening workout might finally help me fix one of mine.
The post My recent lesson in overtraining – and in the power of seeing first-hand the impacts of positive health changes appeared first on Peter Attia.
Exclusive reliance on HbA1c and other static metrics may miss the opportunity for early intervention
The post Assessing metabolic health: where HbA1c falls short and how it compares to fasting glucose, CGM, and OGTT appeared first on Peter Attia.
Early detection of dementia via effective connectivity mapping, the geroprotective potential of pentadecanoic acid, bacteria that convert blood to ABO-universal, a novel target for cancer immunotherapy, and expandable intragastric capsules for treating obesity
The post Research Worth Sharing, July 2024 Edition appeared first on Peter Attia.
“This is the beginning of a type of technology that I hope, over the coming decade, can make screening, especially for melanoma, to be a more effective tool.” —Peter Attia
The post #308 – AMA #61: Sun exposure, sunscreen, and skin health: relationship between sun exposure and skin cancer, vitamin D production, and photoaging, how to choose a sunscreen, and more appeared first on Peter Attia.
A recent case-control study reports that menopausal hormone therapy is associated with increased risk of dementia, but results have little relevance for modern clinical practice
The post Does hormone replacement therapy impact dementia risk? appeared first on Peter Attia.
“The name of the game is play the game and stay in the game forever. And so we are really looking to minimize injury here and we're looking to minimize burnout.” —Peter Attia
The post #307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D. appeared first on Peter Attia.
Same study, different day: A recent study linking the sweetener xylitol to increased risk of cardiovascular events should ring a bell – but not an alarm.
The post Does xylitol increase risk of cardiovascular disease? appeared first on Peter Attia.
“Metabolic health, first and foremost, is the goal of nutrition.” —Peter Attia
The post #306 – AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more appeared first on Peter Attia.
A recent study reporting nearly 100% penetrance of the high-risk APOE-e4 variant is a lesson on the importance of unbiased sampling
The post Is Alzheimer’s disease unavoidable for individuals with a high-risk APOE genotype? appeared first on Peter Attia.
Is there any merit to the idea that consuming more protein increases one’s risk of developing or dying from cancer?
The post Do high protein diets increase cancer risk? appeared first on Peter Attia.
“The older you get… you have to be much more acutely aware of what your body can and can't do. And that's part of what HRV can help you understand.” —Joel Jamieson
The post #305 ‒ Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson appeared first on Peter Attia.
Can reducing heavy alcohol intake significantly lower cardiovascular risk, or is the damage already done?
The post Reducing heavy alcohol intake: a lifeline for cardiovascular health appeared first on Peter Attia.
“Getting a high VO2 max and being very strong are very hard to do. They take a long time. Everybody can do them, but they can't be done quickly and easily, so therefore, they are the tip of the spear.” —Peter Attia
The post #304 – NEW: Introducing quarterly podcast summaries – Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more appeared first on Peter Attia.
A new study shows that the oft-ignored metric is strongly associated with heart attacks, regardless of the presence or absence of standard modifiable risk factors for cardiovascular disease
The post High Lp(a) warrants intervention, even without other cardiovascular risk factors appeared first on Peter Attia.
“I have this dream that people might be able someday to benefit from klotho, this factor that naturally circulates in our body, that helps with longevity, that helps with other organ systems and enhances the brain.” —Dena Dubal
The post #303 – A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer’s disease | Dena Dubal, M.D., Ph.D. appeared first on Peter Attia.
A collection of past newsletters on topics including continuous glucose monitors, fish oil, nutritional epidemiology, fostering meaningful friendships, and traffic safety
The post Oldies-But-Goodies, May 2024 Edition appeared first on Peter Attia.
“The average person you're seeing with MASLD is much more at risk for cardiovascular-related outcomes and malignancy-related outcomes from their metabolic health than they are for liver-related risks.” —Julia Wattacheril
The post #302 – Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage MAFLD and liver disease | Julia Wattacheril, M.D., M.P.H. appeared first on Peter Attia.
A listener finds an educational use for one of my favorite sports
The post When it comes to health, appearances can be deceiving: a lesson from egg boxing appeared first on Peter Attia.
“Inflammation really becomes chronic once it's persisted for several months, but it can persist for much longer than that.” —Peter Attia
The post #301 – AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it appeared first on Peter Attia.
A proof-of-concept method for adding ovarian cancer screening to existing protocols
The post Can ovarian cancer be detected by genetic analysis of cervical cancer screening samples? appeared first on Peter Attia.
A refresher on why you should care about body composition and a practical guide to determining and interpreting your measurements
The post Body composition: impact on disease risk and how to assess and improve it appeared first on Peter Attia.
“The probability that having a high VO2 max, high muscle mass, and high muscle strength are going to increase the length of your life and improve the quality of your life. . .is so high that to act in disregard of that is irresponsible.” —Peter Attia
The post #300 – Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise? appeared first on Peter Attia.
How much time should a person spend exercising? However long it takes to see meaningful improvements in VO₂ max and strength
The post With exercise, results matter more than “time served” appeared first on Peter Attia.
“Senna lived 10 lives in his 34 years. And not only that, he's one of the few people who still matters in his death.” —Peter Attia
The post Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death appeared first on Peter Attia.
A recent study claims that late-night sleep loss is more damaging than early-night sleep loss, but the data leave ample room for doubt
The post Does the timing of sleep loss during the night impact subsequent negative metabolic effects? appeared first on Peter Attia.
"It's the exercise that makes you respond way more to the same or less amount of protein that you ingest.” —Luc van Loon
The post #299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D. appeared first on Peter Attia.
Distracting from the approaches that matter
The post More “hack” than “bio”: why biohacking sends the wrong messages about the pursuit of health and longevity appeared first on Peter Attia.
“If we inquire, if we become curious about ourselves, we learn so much more about what is going on inside of us and it can guide us towards change.” —Paul Conti
The post #298 ‒ The impact of emotional health on longevity, self-audit strategies, improving well-being, and more | Paul Conti, M.D. appeared first on Peter Attia.
A recent report that high protein intake contributes to atherosclerosis has limited relevance to anyone but transgenic mice
The post Silencing the alarm over a recent paper on dietary protein and atherosclerosis appeared first on Peter Attia.
“I've seen a lot of cases of iron deficiency. I've seen a lot of cases of iron deficiency anemia. I can't tell you I've seen one that isn't attributable to some combination of … low iron in the diet, poor absorption, or blood loss.” —Peter Attia
The post #297 – AMA #58: Iron: its role in health, testing methods, and strategies for preventing and managing iron deficiency appeared first on Peter Attia.
Age-related muscle declines are not as inevitable as you might think.
The post Resistance training partially reverses some of the hallmarks of aging type II muscle fibers appeared first on Peter Attia.
Everything you need to know about VO2 max
The post The [almost] unbelievable effects of a high maximal aerobic capacity on all-cause mortality appeared first on Peter Attia.
“Toe weakness is the single biggest predictor of falls when we age.” —Courtney Conley
The post #296 ‒ Foot health: preventing and treating common injuries, enhancing strength and mobility, picking footwear, and more | Courtney Conley, D.C. appeared first on Peter Attia.
Organ-specific aging, a blood-based test for brain tumors, avoiding bananas in smoothies, stair-climbing tests for frailty, and omega-3 intake and CVD
The post Research Worth Sharing, March 2024 Edition appeared first on Peter Attia.
"This paper basically addresses how our beliefs about the drugs we take impacts how they affect us at a real level, not just at a subjective level, but at a biological level.” —Andrew Huberman
The post #270 ‒ Journal club with Andrew Huberman: metformin as a geroprotective drug, the power of belief, and how to read scientific papers appeared first on Peter Attia.
A retrospective study offers hope
The post More than glycemic control: SGLT2 inhibitors may extend lung cancer survival appeared first on Peter Attia.
“I think epidemiology has a place, but I think the pendulum has swung a little too far, and it has been asserted as being more valuable than I think it probably is.” —Peter Attia
The post #269 – Good vs. bad science: how to read and understand scientific studies appeared first on Peter Attia.
Melittin, the main component of honeybee venom, has shown promise as a basis for chemotherapeutic drugs to combat treatment-resistant breast cancer
The post Can a peptide found in bee stings offer hope for treatment-resistant breast cancers? appeared first on Peter Attia.
Sugar substitutes offer sweet taste with minimal calories, yet they remain controversial. How well do they solve the problems associated with traditional sugar, and where do they fall short?
The post Sugar substitutes: deep dive into the pros, cons, available options, and impact on metabolic health appeared first on Peter Attia.
"There are literally tens of thousands of genetic variants in your genome, and what they mean and whether or not they do anything whatsoever is hard to know." —Wendy Chung
The post #268 ‒ Genetics: testing, therapy, editing, association with disease risk, autism, and more | Wendy Chung, M.D., Ph.D. appeared first on Peter Attia.
Research shows that noninvasive neuromodulation can improve performance in memory tasks. Is this technique simply a research tool, or is it a therapy of the future?
The post Improving memory with transcranial neuromodulation appeared first on Peter Attia.
“Early detection is going to allow our same toolbox of drugs to be massively more effective.” —Keith Flaherty
The post #267 ‒ The latest in cancer therapeutics, diagnostics, and early detection | Keith Flaherty, M.D. appeared first on Peter Attia.
Engineered T cells “reboot” the immune system by depleting B cells and autoantibodies
The post Successful, early results using CAR T cells to treat an autoimmune disease appeared first on Peter Attia.
“With how much uncertainty there is in genetic testing, I just think everybody needs to be thoughtful about it before they do it.” —Peter Attia
The post #266 – AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more appeared first on Peter Attia.
Aging weakens the regulatory systems for maintaining water balance, necessitating more conscious oversight of fluid intake to prevent dehydration.
The post How does aging increase risk of dehydration? appeared first on Peter Attia.
“Part of living a meaningful life is to be conscious of that fact that we don't get all the time we would wish to have.” —Oliver Burkeman
The post #265 – Time, productivity, and purpose: insights from Four Thousand Weeks | Oliver Burkeman appeared first on Peter Attia.
Last month, the International Agency for Research on Cancer designated the low-calorie sweetener aspartame as “possibly carcinogenic,” quickly leading to concern, confusion, and criticism.
The post Silencing the alarm on aspartame and cancer appeared first on Peter Attia.
“Just like we talked about in the shoulder, and the knee, and the hip, any mechanical trauma to the joint puts you at increased risk for arthritis of that joint.” —Adam Cohen
The post #264 ‒ Hip, knee, ankle, and foot: diagnosis, treatment, and surgery of the lower extremities | Adam Cohen, M.D. appeared first on Peter Attia.
Age-related hearing loss is very common and has long been known to correlate strongly with cognitive decline. A just-published randomized trial sought to evaluate causality in this association. What do we know now?
The post Can treating hearing loss improve cognitive trajectories and reduce dementia risk? appeared first on Peter Attia.
An endeavor to settle the debate of high- vs. low-protein diets for increasing lifespan and healthspan
The post Dietary protein: friend or foe of healthy aging? appeared first on Peter Attia.
“If you bring me a patient with concussion, I can pretty much tell you I can get that patient better. There are highly effective treatments with this injury.” —Micky Collins
The post #263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D. appeared first on Peter Attia.
Low-dose colchicine, an anti-inflammatory drug, was recently approved by the FDA to reduce risk of cardiovascular events
The post First anti-inflammatory medication approved for treatment of ASCVD appeared first on Peter Attia.
“[Heart rate recovery] is one of the metrics that we should care about just as we care about VO2 max and just as we care about resting heart rate.” —Peter Attia
The post #262 – AMA #49: Heart rate recovery, strength training, rucking, kidney function, and brain health appeared first on Peter Attia.
A recent study investigated the safety and effectiveness of at-home ketamine-assisted therapy for the treatment of depression and anxiety.
The post Ketamine-Assisted Therapy: A Promising Approach for Treating Depression and Anxiety? appeared first on Peter Attia.
“I would never want anybody to come away from this thinking, ‘I'm too old to do anything about it.’ I think as long as you're breathing, you have a chance to do something about it.” —Peter Attia
The post #261 ‒ Training for The Centenarian Decathlon: zone 2, VO2 max, stability, and strength | Peter Attia, M.D. appeared first on Peter Attia.
The personal story of a podcast listener who sought to gain a better picture of his cardiovascular health – and who saved his own life as a result.
The post A case study on the importance of taking charge of one’s own health appeared first on Peter Attia.
A pitstop to look back on the last five years and forward to the road ahead
The post The Drive Turns Five appeared first on Peter Attia.
“Clinicians don't ask about it. Patients are embarrassed to ask about it. And that's the suffering in silence.” —Mohit Khera
The post #260 ‒ Men’s Sexual Health: why it matters, what can go wrong, and how to fix it | Mohit Khera, M.D., M.B.A., M.P.H. appeared first on Peter Attia.
A new study set off a media storm over taurine’s potential in delaying aging and extending lifespan. Great news – if you’re a mouse.
The post Taurine improves the health and longevity of mice and monkeys – but what about men? appeared first on Peter Attia.
"I can't tell you how many women soldier on either avoiding sex or in pain because they don't either know or feel validated to seek treatment." —Sharon Parish
The post #259 – Women’s sexual health: Why it matters, what can go wrong, and how to fix it | Sharon Parish, M.D. appeared first on Peter Attia.
But the effects of frequent, sub-minute bouts of high-intensity movement have not convinced me to change my exercise routine.
The post Cumulative time spent in “vigorous” physical activity lowers mortality risk appeared first on Peter Attia.
“If you care about your brain, if you care about your heart and if you care about your kidneys, you need low blood pressure. I think we can say that as confidently as we can say almost anything in medicine.” —Peter Attia
The post #258 – AMA #48: Blood pressure—how to measure, manage, and treat high blood pressure appeared first on Peter Attia.
A study investigated the effects of different dietary levels of carbohydrates on mitochondrial respiration, but mechanistic conclusions are premature.
The post Does carbohydrate load impact the balance between fat storage and oxidation? appeared first on Peter Attia.
"If you're trying to maintain a basic set of cognitive functions, [it is important] to actively work on ways to increase headroom, increase absolute capacity throughout the lifespan. Because at some point capacity will decrease, but you want to push that out as far as you can." —Tommy Wood
The post #257 ‒ Cognitive decline, neurodegeneration, and head injuries: mitigation and prevention strategies, supplements, and more | Tommy Wood, M.D., Ph.D. appeared first on Peter Attia.
A recent randomized trial investigated the effect of NMN supplementation on NAD levels, biological aging, and exercise performance. What can we believe from their results?
The post Separating substance from nonsense in a study on NMN supplements appeared first on Peter Attia.
In this special episode of The Drive, Peter provides a comprehensive overview of the various endocrine systems: the thyroid system,...
The post #256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D. appeared first on Peter Attia.
A recent study reported that hypercholesterolemia is associated with reduced mortality, but it falls short of upsetting conventional wisdom
The post “The cholesterol paradox”: a catchy phrase for an idea with no substance appeared first on Peter Attia.
“One of the things that is so dangerous about this disorder is that the plaque that you get in FH is a soft plaque.” —John Kastelein
The post #255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D. appeared first on Peter Attia.
My recent podcast with Dr. JoAnn Manson evidently raised as many questions about HRT as it answered, so let’s take a closer look at the evidence for risks and benefits.
The post Clearing the air on hormone replacement therapy appeared first on Peter Attia.
“If we're talking about [activating brown adipose tissue] as a solution for overweight or obesity in adults, it's not a needle mover.” —Peter Attia
The post #254 – AMA #47: Cold therapy: pros, cons, and its impact on longevity appeared first on Peter Attia.
A study claiming that daily consumption of cheese and wine may improve long-term cognition seems more like a bad joke than reliable science.
The post Don’t drink and science: why a study on the cognitive effects of wine and cheese is sheer stupidity appeared first on Peter Attia.
“It’s so important for women to understand that the absolute risks of these hormones are much lower in early menopause than in later menopause.” —JoAnn Manson
The post #253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D. appeared first on Peter Attia.
Why exercise-related acute fluctuations in this biomarker shouldn’t be a cause for distress
The post Supramaximal exercise transiently raises serum uric acid appeared first on Peter Attia.
“My perspective has shifted as any scientist that's following data should… When new data comes out, you have to reassess things.” —Rhonda Patrick
The post #252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D. appeared first on Peter Attia.
Mixing apples and oranges and winding up with garbage
The post How failures in study selection can sink a meta-analysis appeared first on Peter Attia.
The imperative for effective weight management strategies in children and teens is clear, but in our desperation for effective obesity treatments, are we allowing ourselves to be too shortsighted on testing?
The post Is a recent clinical trial enough to support the use of semaglutide in treating adolescent obesity? appeared first on Peter Attia.
“The bottom line here is the earlier you were diagnosed with type 2 diabetes, the higher your risk of dementia.” —Peter Attia
The post #251 – AMA #46: Optimizing brain health: Alzheimer’s disease risk factors, APOE, prevention strategies, and more appeared first on Peter Attia.
A secondary analysis of biomarker data from REDUCE-IT raises questions about the apparent benefits of EPA-derivative icosapent ethyl
The post A new analysis of REDUCE-IT: benefits of omega-3s vs. harm from placebos appeared first on Peter Attia.
“The best marathoners in the world would smash almost everyone you know in a 100-meter dash. They're blazingly fast.” —Andy Galpin
The post #250 ‒ Training principles for longevity | Andy Galpin, Ph.D. (PART II) appeared first on Peter Attia.
In the 20 years since the Human Genome Project was completed in 2003, we’ve dramatically expanded our understanding of the impact of genetics on human health, but the work is far from finished.
The post Twenty Years of the Human Genome: Growing Older and Wiser appeared first on Peter Attia.
“I want to communicate the beauty and utility of biology. I want to do that by being a teacher and a storyteller.” —Andrew Huberman
The post #249 ‒ How the brain works, Andrew’s fascinating backstory, improving scientific literacy, and more | Andrew Huberman, Ph.D. appeared first on Peter Attia.
A study published this winter raised concerns over gas stoves and childhood asthma, but we have many options for eliminating the excess risk.
The post Putting out the fire on the gas stove debate appeared first on Peter Attia.
“You can't solve or even attempt to solve complicated problems if you aren't asking the right questions and you don't have the right frameworks.” —Peter Attia
The post #248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more appeared first on Peter Attia.
Researchers have recently discovered that a new drug called locamidazole may help to prevent loss of bone density and muscle mass during periods of inactivity, but it’s no substitute for all of the benefits of exercise.
The post Can a new drug mimic the effects of exercise on bone and muscle? appeared first on Peter Attia.
“If everybody got truly optimal medical therapy, if we didn't have barriers to using all these tools in everybody, I think this disease would largely be controlled.” —Ethan Weiss
The post #247 ‒ Preventing cardiovascular disease: the latest in diagnostic imaging, blood pressure, metabolic health, and more | Ethan Weiss, M.D. appeared first on Peter Attia.
When it comes to therapy, the quality of the patient-therapist relationship is critical to success.
The post Finding the right fit in a psychotherapist appeared first on Peter Attia.
"The thing that concerns me the most with these drugs. . .is this drive towards sarcopenia.” —Peter Attia
The post #246 – AMA #45: Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent appeared first on Peter Attia.
A new retrospective study contradicts previous evidence of metformin’s potential effects on lifespan extension in a general population, but for real answers, randomized trials are needed.
The post A recent metformin study casts doubts on longevity indications appeared first on Peter Attia.
“I think inner peace is the greatest currency.” —Lewis Howes
The post #245 ‒ Overcoming trauma, finding inner peace, and living a meaningful and fulfilling life | Lewis Howes appeared first on Peter Attia.
A newly-published study caught public attention by reporting an association between the common sweetener erythritol and increased risk of heart attack and stroke, but there’s more to the story.
The post More hype than substance: erythritol and cardiovascular risk appeared first on Peter Attia.
“I liken the human genome to a score of music, but a score is lifeless. There's no music in a score, it's just a code. You need a musician to bring it to life, and the cell is that musician.” —Sid Mukherjee
The post #244 ‒ The history of the cell, cell therapy, gene therapy, and more | Siddhartha Mukherjee appeared first on Peter Attia.
A 40-year-old study shows that animals’ emotional states can impact physiology, a reminder that they are more complex and individual than we often give them credit for.
The post How much control can we really have in studies on animals? appeared first on Peter Attia.
“Six out of every ten illicit counterfeit pills have enough fentanyl to kill somebody. So if we can take ten pills off the street, we're potentially saving six lives.” —Anthony Hipolito
The post #243 ‒ The fentanyl crisis and why everyone should be paying attention | Anthony Hipolito appeared first on Peter Attia.
Clinical trials have generated impressive data on the effects of GLP-1 agonists on body weight and BMI, but how do these drugs perform in terms of body composition?
The post Lean mass loss on GLP-1 receptor agonists: a downside of the “miracle drugs” appeared first on Peter Attia.
“Trends matter. You're treating what you see, but you're mindful of the trends.” —Peter Attia
The post #242 – AMA #44: Peter’s historical changes in body composition with his evolving dietary, fasting, and training protocols appeared first on Peter Attia.
A recent review suggests that screen time may not be as bad for infants as many of us may think – but only under the right circumstances.
The post Screen time and children’s cognition: a question of context appeared first on Peter Attia.
“The day you stop growing is the day that you age.” —Ric Elias
The post #241 ‒ Living intentionally, valuing time, prioritizing relationships, and more keys to a rich life | Ric Elias (Part 2) appeared first on Peter Attia.
“The day you stop growing is the day that you age.” —Ric Elias
The post #241 ‒ Living intentionally, valuing time, prioritizing relationships, and more keys to a rich life | Ric Elias (Part 2) appeared first on Peter Attia.
Though exercise has virtually unlimited health benefits, addiction to exercise can be a danger to mental and physical well-being. But what distinguishes exercise addiction from healthy engagement in physical activity?
The post The dangers of “healthy” addictions appeared first on Peter Attia.
“HDL cholesterol itself is not directly and causally protective against atherosclerotic cardiovascular disease.” —Dan Rader
The post #240 ‒ The confusion around HDL and its link to cardiovascular disease | Dan Rader, M.D. appeared first on Peter Attia.
Every January, NASA holds a Day of Remembrance to honor the lives of astronauts lost to tragedy. But perhaps the greatest tribute we can make is to learn from past mistakes.
The post Twenty years after the Columbia disaster, what can we learn from the mistake of ignoring problems? appeared first on Peter Attia.
“The atrophy of fast-twitch fibers is the almost exclusively the problem with aging and muscle.” ‒Andy Galpin
The post #239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I) appeared first on Peter Attia.
Two recent randomized trials found that biasing food intake toward the end of the day increases appetite and may reduce energy expenditure.
The post To reduce appetite, skip late-night snacks appeared first on Peter Attia.
“ApoB is a necessary, though not sufficient, factor in the development of ASCVD which means the more you lower it, the more you lower risk. Full stop.” —Peter Attia
The post #238 – AMA #43: Understanding apoB, LDL-C, Lp(a), and insulin as risk factors for cardiovascular disease appeared first on Peter Attia.
Coffee consumption is associated with reduced risk of Alzheimer’s disease and other neurodegenerative processes, but the effect may be more than a matter of caffeine.
The post Non-caffeine components of coffee and their effects on neurodegenerative diseases appeared first on Peter Attia.
“In the game of life, what I'm solving for is regret minimization. . .I want the highest score in net fulfillment.” —Bill Perkins
The post #237 ‒ Optimizing life for maximum fulfillment | Bill Perkins appeared first on Peter Attia.
Moderna recently announced preliminary results of a clinical trial involving a personalized antitumor mRNA vaccine, and despite the knee-jerk uproar, the treatment may prove to be another useful weapon in the battle against cancer
The post Antitumor mRNA vaccines are cause for optimism appeared first on Peter Attia.
“When you think of brain health, it's not just the cognitive piece, but it's the movement piece too.” ‒ Kellyann Niotis
The post #236 ‒ Neurodegenerative disease: pathology, screening, and prevention | Kellyann Niotis, M.D. appeared first on Peter Attia.
When it comes to safety, the distinct advantages of automatic and manual vehicles depend on who’s in the driver’s seat.
The post The Safety Debate Between Manual and Automatic Transmissions appeared first on Peter Attia.
“Most 40 year olds, 50 year olds, they have pain anyway. So I'd rather be strong and have pain than be weak and have pain.” —Layne Norton
The post #235 ‒ Training principles for mass and strength, changing views on nutrition, creatine supplementation, and more | Layne Norton, Ph.D. appeared first on Peter Attia.
A recent study investigated how nature walks impact brain regions involved in stress responses but trips on its own assumptions
The post Understanding nature’s effects on stress requires more than intuition appeared first on Peter Attia.
“I was able to grow throughout the experience and have different opinions on myself and different opinions on how I approached health and wellness.” —Chris Hemsworth
The post #234 ‒ Chris Hemsworth on Limitless, longevity, and happiness appeared first on Peter Attia.
A new study links NR supplementation with accelerated cancer progression in mice.
The post NR supplements: wasted money may not be the only risk with these questionable “anti-aging” drugs appeared first on Peter Attia.
“On the edges [of science] there's always going to be exceptions, potentially, for things that are even sort of ‘ironclad’.” —Peter Attia
The post #233 – AMA #42: Optimizing sleep – bedtime routine, molecule regimen, sleep trackers, sauna, & more appeared first on Peter Attia.
Outlive: The Science and Art of Longevity hits bookshelves March 28, 2023
The post Book release date announcement appeared first on Peter Attia.
“One should never make their clinical, especially surgical, decision-making on just an MRI.”‒ Alton Barron
The post #232 ‒ Shoulder, elbow, wrist, and hand: diagnosis, treatment, and surgery of the upper extremities | Alton Barron, M.D. appeared first on Peter Attia.
At all stages of life, we spend more time alone than ever before in history. Are we growing lonely?
The post Does solitude equate to loneliness? appeared first on Peter Attia.
To the general public, the trial-and-error process of science and medicine may erode confidence, but without it, we’d have no science and medicine at all.
The post When it comes to medical advice, is less always more? appeared first on Peter Attia.
“We have reached the limits of medicine 2.0 capacity, and if longevity is something we are aspiring for, we need a new strategy.” —Peter Attia
The post #231 – AMA #41: Medicine 3.0, developments in the field of aging, healthy habits in times of stress, and more appeared first on Peter Attia.
A recent retrospective study suggests that flu vaccines reduce risk of Alzheimer’s disease, but the study raises as many questions as it answers.
The post Can an annual flu vaccine reduce your risk of Alzheimer’s disease? appeared first on Peter Attia.
“How we live the first half of our lives really influences our freedom for morbidity and mortality the second half of our lives.” —Erin Michos
The post #230 ‒ Cardiovascular disease in women: prevention, risk factors, lipids, and more | Erin Michos, M.D. appeared first on Peter Attia.
Statin therapy is known to raise Lp(a) particle concentration in some patients, but how does this impact the overall effect of these medications on ASCVD risk?
The post Reassuring new data on statin-induced Lp(a) elevation appeared first on Peter Attia.
“Not everybody dies from atherosclerosis, but… everybody dies with it." —Peter Attia
The post #229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB appeared first on Peter Attia.
Blood from young mice has rejuvenating effects on old mice, but it’s too early to translate these results into treatments for humans.
The post Modern Vampirism: “Young Blood” Transfusions appeared first on Peter Attia.
“You will always lose muscle mass when you attempt a fat-loss phase, but the leaner you get, the greater the risk of that muscle loss because you no longer have that caloric cushioning to support that.” —Holly Baxter
The post #228 ‒ Improving body composition, female-specific training principles, and overcoming an eating disorder | Holly Baxter, APD appeared first on Peter Attia.
A recent narrative review hypothesizes a key role for myokine disruption caused by physical inactivity.
The post Muscle Mass and Cognitive Function appeared first on Peter Attia.
“We don't want to be consuming protein for energy purposes at all. We want to be consuming protein for muscle protein synthesis.” —Peter Attia
The post #227 – AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more appeared first on Peter Attia.
A recently published NEJM paper appears to show that colonoscopy screenings do not reduce risk of colorectal cancer death. As is often the case, the results have been taken out of context and their implications grossly overestimated.
The post Confusion over results of a recent colonoscopy trial appeared first on Peter Attia.
Arthur Brooks is a social scientist, professor at Harvard University, a columnist for The Atlantic, and the bestselling author of...
The post #226 ‒ The science of happiness | Arthur Brooks, Ph.D. appeared first on Peter Attia.
Could watching scary movies actually be good for your health?
The post How horror may reduce anxiety and improve mental well-being appeared first on Peter Attia.
“Dancing on the edge of failure, you can realize that it's not that big of a deal.” —Michael Easter
The post #225 ‒ The comfort crisis, doing hard things, rucking, and more | Michael Easter, MA appeared first on Peter Attia.
A recent case study shines light on why some individuals are resistant to PCSK9 inhibitors.
The post The genetics of PCSK9i nonresponders appeared first on Peter Attia.
“We want weight loss, but we don't want people to lose any lean mass. Especially if they're adults.” —Don Layman
The post #224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D. appeared first on Peter Attia.
A quick search for "hangover prevention" will send you down a rabbit hole of advice. While staying hydrated and not drinking too much are obvious solutions, there's a new hangover pill called Myrkl that's garnering much attention. In this article, you'll find out exactly what is in these pills, whether they might actually work (or not), and potential downsides.
The post A “miracle pill” for hangover prevention? appeared first on Peter Attia.
“Time, intensity, and specificity are going to be necessary components to give you the optionality to be able to be as physically active as possible when you're in the final decade of your life.” —Peter Attia
The post #223 – AMA #39: The Centenarian Decathlon, zone 2, VO2 max, and more appeared first on Peter Attia.
Motor vehicle accidents are a common yet often overlooked cause of death – and the numbers are rising.
The post The Epidemic on the Road appeared first on Peter Attia.
“It's really important that we be willing to change our beliefs about nutrition and other aspects of health as more data comes in.” —Matt Kaeberlein
The post #222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D. appeared first on Peter Attia.
Unfortunately, scientific publishing is riddled with myriad problems, many of which likely can’t be solved without completely rethinking current processes and the underlying research culture. However, there are still small, short-term changes that are relatively easy to implement and can yield meaningful improvements in research integrity.
The post Small steps toward improving research reliability appeared first on Peter Attia.
“Sleep is the greatest life support system you could ever wish for. It’s a remarkable health insurance policy, it’s largely democratic, free and largely painless.” —Matt Walker
The post #221 ‒ Understanding sleep and how to improve it appeared first on Peter Attia.
This past July, a news article published in Science sent shockwaves through the scientific community when it reported that one of the most influential and frequently-cited publications in Alzheimer’s disease (AD) research was evidently based on fraud.
The post Adding context to the Alzheimer’s disease research fraud charges appeared first on Peter Attia.
This video clip is from episode #203 — AMA #34: What causes heart disease? — originally released on April 18,...
The post Heart Disease: Labs & Diagnostic Tests appeared first on Peter Attia.
“You could time your psychological therapy when your brain is most plastic, most able to learn new things.” —Celia Morgan
The post #220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D. appeared first on Peter Attia.
According to a May 2021 survey, Americans report having fewer close friendships than they did 30 years ago. But according to a recent conversation I had with author and social scientist Arthur Brooks, friendship is one of the key factors in finding and maintaining happiness as we age.
The post Prioritizing “real friends” over “deal friends” appeared first on Peter Attia.
“I honestly believe that anybody could benefit from learning DBT skills.” —Shireen Rizvi
The post #219 ‒ Dialectical behavior therapy (DBT): skills for overcoming depression, emotional dysregulation, and more | Shireen Rizvi, Ph.D., ABPP appeared first on Peter Attia.
“A calorie is a calorie” seems like a simple and obvious statement. But do different macronutrients vary in their ability to drive obesity? A recent study by Dr. Kevin Hall and colleagues provides new clues – and likely new fodder for debate.
The post Different effects of fat- vs. carbohydrate-restriction on neural reward signaling appeared first on Peter Attia.
This clip is from AMA #26: Continuous glucose monitors, zone 2 training, and a framework for interventions, originally released on...
The post The five main tools for managing blood glucose numbers appeared first on Peter Attia.
“We tend to be far more confident than we turn out to be justified in being.” —Peter Attia
The post #218 – AMA #38: Can you exercise too much? appeared first on Peter Attia.
For vitamin D supplementation to have any effect relative to placebo, it needs to be increasing the body’s supply of vitamin D, and if it doesn’t, then the treatment and placebo groups are effectively identical. So did the researchers achieve a difference in vitamin D levels over the course of the study?
The post Vitamin D(éjà vu): new study, same old problems appeared first on Peter Attia.
“The idea is to live a long time and then die quickly with minimal disability." —Mike Joyner
The post #217 ‒ Exercise, VO2 max, and longevity | Mike Joyner, M.D. appeared first on Peter Attia.
Ultimately, the long-term benefits of lowering apoB through a one-time treatment may make this not only a viable future option, but potentially an intervention that could change preventive cardiovascular medicine.
The post First Case of Human PCSK9 Gene-Editing appeared first on Peter Attia.
"My big hope is that we're going to be able to have some combination of directed, metabolic immune supplements and diet that really work with therapy to treat cancer.” —Josh Rabinowitz
The post #216 – Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D. appeared first on Peter Attia.
Not enough can be said about the importance of grip strength as you age. It’s one of the strongest physical associations with longer life.
The post Avoiding Injury Part II: Grip Strength appeared first on Peter Attia.
This clip is from AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity,...
The post Alzheimer’s disease — what labs can tell you about your risk appeared first on Peter Attia.
This clip is from episode #138 – Lauren Miller Rogen and Richard Isaacson, M.D.: Alzheimer’s disease prevention—patient and doctor perspectives,...
The post Why does Alzheimer’s disease affect more women than men? appeared first on Peter Attia.
“The reason I call it “The Second Brain” is that, like the brain in the head, the nervous system of the gut is able to function and control reflexes and behavior independently of any influence from the brain or spinal cord.” —Michael Gershon
The post #215 – The gut-brain connection | Michael Gershon, M.D. appeared first on Peter Attia.
Accidental injury is among the leading causes of death in the developed world, and even when an injury itself is not directly responsible for ending one’s life, the associated debilitation can hasten the onset and progression of other health concerns.
The post Avoiding Injury Part I: Eccentric Strength appeared first on Peter Attia.
This audio clip is from episode #47 – Matthew Walker, Ph.D., on sleep – Part I of III: Dangers of...
The post The connection between sleep and Alzheimer’s disease appeared first on Peter Attia.
This audio clip is from episode #48 with Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease, cancer,...
The post The connection between sleep and heart disease appeared first on Peter Attia.
“The bones are mechanical sensory entities that are going to remodel in proportion to how much mechanical stress they're under…so lifting heavy stuff matters.” —Peter Attia
The post #214 – AMA #37: Bone health—everything you need to know appeared first on Peter Attia.
This audio clip is from episode #48 with Matthew Walker, Ph.D., on sleep – Part II of III: Heart disease,...
The post Fighting cancer and improving immune function with sleep appeared first on Peter Attia.
What we can learn from the awkward, soccer-playing robots of RoboCup?
The post And the 2050 World Cup champions are… robots? appeared first on Peter Attia.
This video clip is from episode #58 – AMA with sleep expert, Matthew Walker, Ph.D.: Strategies for sleeping more, sleeping...
The post Why sleep is the best insurance policy for lifespan and healthspan appeared first on Peter Attia.
“I was frustrated by not being able to diagnose a recurrence earlier.” —Max Diehn
The post #213 ‒ Liquid biopsies and cancer detection | Max Diehn, M.D. Ph.D. appeared first on Peter Attia.
Atherosclerotic cardiovascular disease (ASCVD) is currently the leading cause of death in the U.S. One of the most effective ways to reduce risk of ASCVD mortality is reduction of apoB particle number, typically estimated by LDL cholesterol (LDL-C) concentrations.
The post Cumulative effects of LDL-C reduction in mitigating cardiovascular risk appeared first on Peter Attia.
Yesterday marks the four-year anniversary since we launched The Drive. For this week’s newsletter, we’re looking back at some of the most popular episodes over this past year.
The post The Drive podcast turns 4 appeared first on Peter Attia.
This clip is from episode #18 – Richard Isaacson, M.D.: Alzheimer’s prevention, originally release on October 1, 2018.
The post Does exercise reduce the risk of Alzheimer’s disease? appeared first on Peter Attia.
This video clip is from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D., originally...
The post Lp(a) and CVD risk & clinical tests to measure Lp(a) appeared first on Peter Attia.
“This system works better at protecting against fat loss than it does against fat gain.” —Stephan Guyenet
The post #212 – The neuroscience of obesity | Stephan Guyenet, Ph.D. appeared first on Peter Attia.
A recent study explored whether supplementation with the beneficial compounds in cocoa could have a clinically-relevant effect on ASCVD.
The post Can cocoa help prevent cardiovascular death? appeared first on Peter Attia.
This clip is from episode #187 – Sam Apple: The Warburg Effect—Otto Warburg’s cancer metabolism theory, originally released on December...
The post Sugar & Cancer: Does Fructose Cause Cancer? appeared first on Peter Attia.
This video clip is taken from episode #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D., originally released on...
The post Is natural sugar from fruit just as ‘bad’ as added sugar? appeared first on Peter Attia.
This audio clip is from “Ask Me Anything” (AMA) episode #15 — Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more, originally...
The post Metabolic dysfunction case study and a framework for metabolic health appeared first on Peter Attia.
This audio clip is from “Ask Me Anything” (AMA) episode #36 — all things fruits and vegetables, originally released on June 20,...
The post How metabolic health impacts your ‘optimal’ diet appeared first on Peter Attia.
"There's also a very significant cultural and social component to this thing as well. So I think that's where the tribalism comes from around nutrition.” —Peter Attia
The post #211 – AMA #36: Fruits & vegetables—everything you need to know appeared first on Peter Attia.
“Remission in every patient” reads the New York Times headline about a study published earlier this month in the New...
The post A pilot immunotherapy trial is one step on a long road toward curing cancer appeared first on Peter Attia.
As many of you know, I had shoulder surgery in March 2022. I was recently given clearance to expand my...
The post Exercises After Shoulder Surgery (Post-Op Week 9) appeared first on Peter Attia.
This video clip is from episode #200 – AMA #33: Hydration—electrolytes, supplements, sports drinks, performance effects, and more, originally released...
The post Hydration for Athletes: Should you drink sports drinks with glucose? appeared first on Peter Attia.
This video clip is taken from Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D., originally released on...
The post Why you should stop drinking sugar appeared first on Peter Attia.
This video is a clip from episode #210 – Lp(a) and its impact on heart disease with Benoît Arsenault, Ph.D.,...
The post Peter’s approach to managing patients with high Lp(a) appeared first on Peter Attia.
This clip is from episode #207 – AMA #35: “Anti-Aging” Drugs — NAD+, metformin, & rapamycin, originally released on May...
The post The difference between a ‘clean’ drug and a ‘dirty’ drug appeared first on Peter Attia.
“I think we should advise people to measure Lp(a); that would be a gigantic step.” —Benoît Arsenault
The post #210 – Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D. appeared first on Peter Attia.
Researchers have explored numerous contributors to loss of muscle strength with age, and it appears to boil down to two major factors: muscle quality and neuromuscular innervation.
The post Why do we lose muscle strength with age? appeared first on Peter Attia.
This video clip is from episode #205 – Energy balance, nutrition, & building muscle with Layne Norton, Ph.D. (Pt.2), originally released...
The post The metabolic benefits of exercise & muscle mass appeared first on Peter Attia.
Being able to absorb shock efficiently is critical as we age. In this video, Beth Lewis explains three great exercises...
The post 3 Ways to Train Frontal Plane Motion of the Foot appeared first on Peter Attia.
This video clip is from episode #131 — Beth Lewis: The Art of Stability — originally released on October 5,...
The post Importance of maintaining use of your toes, minimalist footwear, and toe yoga appeared first on Peter Attia.
“People don't just die from disease, they die from the care itself.” —Marty Makary
The post #209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H. appeared first on Peter Attia.
More than a matter of body weight
The post Why do women have lower alcohol tolerance than men? appeared first on Peter Attia.
This audio clip is from our sleep series with Matthew Walker, Ph.D. — episode #58 – strategies for sleeping more,...
The post Is it bad to eat food too close to bedtime? appeared first on Peter Attia.
This audio clip is from our sleep series with Matthew Walker, Ph.D. — episode #127 – fasting, gut health, blue light,...
The post How fasting can impact sleep appeared first on Peter Attia.
This audio clip is from our sleep series with Matthew Walker, Ph.D. — episode #48 – heart disease, cancer, sexual function,...
The post Dieting while sleep deprived appeared first on Peter Attia.
This audio clip is from our sleep series with Matthew Walker, Ph.D. — episode #58 – strategies for sleeping more, sleeping...
The post How is appetite affected by our sleep quality? appeared first on Peter Attia.
Irresponsible reporting misleads new and grieving parents
The post Dangerous messaging around a recent SIDS study appeared first on Peter Attia.
This clip is from “Ask Me Anything” (AMA) episode #35, originally released on May 16, 2022. If you’re a member,...
The post Are there “biomarkers” for aging? appeared first on Peter Attia.
Envision yourself at 90 years old. What do you want to be able to do, physically? Perhaps it’s as simple...
The post Strength and stability are essential for longevity appeared first on Peter Attia.
“There's just a real relief when you stop wishing it was different, whatever it is.” —Kelsey Chittick
The post #208 – Tragedy, grief, healing, and finding happiness | Kelsey Chittick appeared first on Peter Attia.
PedalMe, a London-based e-bike company, recently announced that their employees were not allowed to wear bike helmets for safety reasons. Does their rationale have any merit?
The post Do helmets give cyclists a false sense of security? appeared first on Peter Attia.
This video clip is from episode #176 – AMA #27: The importance of muscle mass, strength, and cardiorespiratory fitness for...
The post How does VO2 max correlate with longevity? appeared first on Peter Attia.
How do triglyceride levels relate to cardiovascular risk?
The post For triglycerides, “normal” may not be “optimal” appeared first on Peter Attia.
This video clip is from episode #175 – The biology of aging, rapamycin, and other interventions that target the aging...
The post The challenges of defining aging with Matt Kaeberlein, Ph.D. appeared first on Peter Attia.
This video clip is from episode #201 – Deep dive back into Zone 2 with Iñigo San-Millán, Ph.D. (Pt. 2),...
The post Potential Risks of NAD Supplements with Iñigo San-Millán, Ph.D. appeared first on Peter Attia.
This video clip is from episode #204 – Centenarians, metformin, and longevity with Nir Barzilai, M.D., originally released on April...
The post About TAME: A Metformin Anti-Aging Clinical Trial with Nir Barzilai, M.D. appeared first on Peter Attia.
I recently posted on Twitter about my frustration with the way the press writes about “good” and “bad” cholesterol, and...
The post Intro to lipids & lipoproteins: why there is no ‘bad’ or ‘good’ cholesterol appeared first on Peter Attia.
“We can do zone 2 our entire lives; we can do it safely, and it just yields enormous dividends.” —Peter Attia
The post #206 – Exercising for longevity: strength, stability, zone 2, zone 5, and more appeared first on Peter Attia.
Existing evidence suggests that nitrates provide benefits for cardiovascular health and exercise performance. Let's discuss some of the recent data.
The post Are nitrates the next big thing for athletic performance? appeared first on Peter Attia.
This video clip is from Ask Me Anything (AMA) #32 — Exercise, squats, deadlifts, BFR, and TRT, originally released on...
The post Fasting & protein: the impact of fasting on muscle mass appeared first on Peter Attia.
This video clip is from episode #205 – Energy balance, nutrition, & building muscle with Layne Norton, Ph.D. (Pt.2), originally...
The post Dispelling myths that excess protein intake increases cancer risk appeared first on Peter Attia.
This audio clip is from episode #202 – Peter on nutrition, disease prevention, sleep, and more, originally released on April...
The post Are you eating enough protein? appeared first on Peter Attia.
“Lean body mass is inversely proportional to your risk of mortality after age 50.” —Layne Norton
The post #205 – Energy balance, nutrition, & building muscle | Layne Norton, Ph.D. (Pt.2) appeared first on Peter Attia.
Either I completely dozed for the past ten years, or the author of a recent news article pulled data from some farcical study. Let’s take a closer look.
The post Does walking 10 minutes per day extend your life? (Hint: No.) appeared first on Peter Attia.
"To me, the takeaway for us, as physicians or people who want to have an extra five years of life or 10 years of life... is nothing matters more than prevention of chronic disease. And by the way, you don't get to prevent it once you have your heart attack. Secondary prevention is not prevention." - Peter Attia, M.D.
The post Lessons from centenarians: why prevention of chronic disease is critical appeared first on Peter Attia.
This audio clip is from ask me anything (AMA) episode #19, originally released on January 18, 2021. If you’re not...
The post How to engage with your doctor appeared first on Peter Attia.
“If you prevent aging and age-related disease, you're going to compress morbidity, too.” — Nir Barzilai
The post #204 – Centenarians, metformin, and longevity | Nir Barzilai, M.D. appeared first on Peter Attia.
A look at whether activating brown fat through cold exposure therapy offers metabolic benefits.
The post Is cold exposure beneficial for metabolic health? appeared first on Peter Attia.
This audio clip is from AMA #16: Exploring hot and cold therapy, originally released on October 12, 2020.
The post Does regular sauna use provide health benefits? appeared first on Peter Attia.
This video clip is from episode #201 – Deep dive back into Zone 2 with Iñigo San-Millán, Ph.D, originally released...
The post How to find your “Zone 2” without using a lactate meter appeared first on Peter Attia.
This audio clip is from our sleep series with Matthew Walker, Ph.D., episode #126 — Matthew Walker, Ph.D.: Sleep and...
The post Alcohol, sleep, and stress: A self-fulfilling prophecy appeared first on Peter Attia.
This audio clip is from our “Ask Me Anything” episode #31 – Heart rate variability (HRV), alcohol, sleep, and more,...
The post The impact of alcohol on sleep appeared first on Peter Attia.
This audio clip is from our “Ask Me Anything” with sleep expert, Matthew Walker (Part I of III), originally released...
The post How alcohol disrupts sleep and contributes to Alzheimer’s disease appeared first on Peter Attia.
This audio clip is from our sleep series with Matthew Walker, Ph.D., episode #49 — Matthew Walker, Ph.D., on sleep...
The post Do THC and CBD help you sleep? appeared first on Peter Attia.
“You can accomplish very important mitochondrial adaptations and very important metabolic adaptations by exercising one hour.” —Iñigo San-Millán
The post #201 – Deep dive back into Zone 2 | Iñigo San-Millán, Ph.D. (Pt. 2) appeared first on Peter Attia.
PR Lotion is believed to buffer acid that builds up in muscles during intense exercise, but can we really believe the hype?
The post Does PR Lotion really improve exercise performance? appeared first on Peter Attia.
This clip is from “Ask Me Anything” (AMA) episode #17, originally released on November 9, 2020. If you’re a member, you...
The post Visceral Fat vs. Subcutaneous Fat — What’s the Difference? appeared first on Peter Attia.
This video clip is taken from Podcast #197 — The science of obesity & how to improve nutritional epidemiology with David...
The post Should BMI be used? Measuring obesity at the individual level appeared first on Peter Attia.
This video clip is taken from Podcast #197 — The science of obesity & how to improve nutritional epidemiology with David...
The post Why is maintaining weight loss more challenging than losing weight? appeared first on Peter Attia.
This clip is from “Ask Me Anything” (AMA) episode #16, originally released on October 12, 2020. If you’re a member, you...
The post Peter on how stress can show up as physical pain appeared first on Peter Attia.
This audio clip is from our “Ask Me Anything” with sleep expert, Matthew Walker (Part I of III), originally released...
The post Stress, Cortisol, and Sleep Deprivation: An Awful Feedback Loop appeared first on Peter Attia.
“You just got to bring yourself back to being present in this moment, and there's always enough to get you through this moment.” —Ryan Hall
The post #199 – Running, overcoming challenges, and finding success | Ryan Hall appeared first on Peter Attia.
Current evidence, and what to do about it
The post Are “safe” levels of air pollution really safe? appeared first on Peter Attia.
This audio clip is from “Ask Me Anything” (AMA) episode #15 — Real-world case studies—metabolic dysregulation, low testosterone, menopause, and more. If...
The post Patient Case Study: Elevated Uric Acid and High Blood Pressure appeared first on Peter Attia.
This video clip is taken from Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D. Rick Johnson...
The post How Peter thinks about managing GFR & high blood pressure in his patients appeared first on Peter Attia.
This video clip is taken from Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D. Rick Johnson...
The post Rick Johnson, M.D. on the impact of high blood pressure on chronic disease appeared first on Peter Attia.
This video clip is taken from Podcast #194 – How Fructose Drives Metabolic Disease with Rick Johnson, M.D. Rick Johnson...
The post Rick Johnson, M.D. on the relationship between salt & blood pressure appeared first on Peter Attia.
“Do eye surgeons need to go to medical school? Yes, because we diagnose brain tumors. We find things that are systemic diseases that have ocular manifestations.” —Steven Dell
The post #198 – Eye health—everything you need to know | Steven Dell, M.D. appeared first on Peter Attia.
Not just a “smoker’s disease”
The post A broader perspective on lung cancer appeared first on Peter Attia.
This audio clip was pulled from “Ask Me Anything” episode #12 — Strategies for longevity (which don’t require a doctor). This...
The post Exercising for Longevity: Peter on Zone 2 and Zone 5 Training appeared first on Peter Attia.
This audio clip was pulled from “Ask Me Anything” episode #21 — Deep dive into olive oil, high-intensity exercise, book update,...
The post Peter Attia on Zone 5 & Anaerobic Training Protocols appeared first on Peter Attia.
“Fructose turns out to have been meant to be this wonderful system for survival, but in our culture with the amount of sugar in foods that we are eating (that either provide sugar or can be turned into fructose), this pathway has become hazardous.” —Rick Johnson
The post #194 – How fructose drives metabolic disease | Rick Johnson, M.D. appeared first on Peter Attia.
Why LDL-lowering treatments don’t pit head against heart
The post Low LDL cholesterol and neural development appeared first on Peter Attia.
"If you have the aspiration of kicking ass when you're 85, you can't afford to be average when you're 50." —Peter Attia
The post Peter Attia on the importance of preserving strength and muscle mass as we age appeared first on Peter Attia.
In this “Ask Me Anything” (AMA) episode, Peter and Bob first answer a variety of questions related to heart rate...
The post #193 – AMA #31: Heart rate variability (HRV), alcohol, sleep, and more appeared first on Peter Attia.
In last week’s newsletter on vaccine mandates, I implored you all to think. Many of you rose to the occasion with insightful feedback.
The post Not another COVID newsletter appeared first on Peter Attia.
This clip is from podcast #88 — Paul Grewal, M.D.: Treating metabolic disease and strategies for long-term health — which...
The post How Peter Attia Prescribes Exercise to His Patients appeared first on Peter Attia.
This video clip is from podcast #131 — Beth Lewis: The Art of Stability — which was originally released on October 5, 2020.
The post Peter Attia & Beth Lewis on Dynamic Neuromuscular Stabilization (DNS) appeared first on Peter Attia.
This video clip is from podcast #131 — Beth Lewis: The Art of Stability — which was originally released on October 5, 2020.
The post The important connection between the ribs and breathing appeared first on Peter Attia.