This podcast is about topics in medicine including human anatomy and physiology among many others. Support this podcast: https://anchor.fm/kmeds/support
CN III - Internal and External Opthalmoplegia
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Strategy for solving Acid-Base Problems
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HMG-COA reductase regulation via phosphorylation and Dephosphorylation
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Cholesterol Synthesis Regulation| SREBP| SCAP | S1P | S2P| SRE
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Pathophysiology of Atherosclerosis
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Hormone sensitive Lipoprotein Lipase
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Lipoprotein Metabolism | Lipoprotein | Apo-protein| B48| B100| HDL| ApoE| ApoCII | VLDL| IDL| LDL | LCAT vs ACAT | Pancreatic lipase, hepatic triglyceride lipase, Chylomicron | SRB1 | ABC1| ABCG1| HDL3, HDL2, CETP| Apo-AI |
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How metabolic Acidosis causes Hyperkalemia. H+ enters all cells including Principal cells. K+ leaves principal cells and enters blood. Leading to Hyperkalemia. High K+ level is maintained by decreasing Na+—K+ ATPase and K+ channel activities.
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How Metabolic Alkalosis results in Hypokalemia | Principal Cells | Basolateral Na+- K+ ATpase | Luminal K+ channel. H+ move from principal cells into blood and K+ move from blood into principal cells and from principal cells into the urinary lumen. Eventual excretion!
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Principal cells | ADH| V2 receptors | Gs Pathway | Aquaporin-2
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ENAC| K-wasting vs K-Sparing diuretics | Spironolactone | Aldosterone | Lumen Electropositivity
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Thiazides | NCC | PTH | Ca++ Reabsorption
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How Furosemide causes Alkalosis and urinary acidification
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NKCC2| Furosemide induced urinary acidification | Diuretics
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CA inhibitors in PCT- Acetazolamide
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P-V loops ESPVR vs EDPVR curves in cardiomyopathies
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How do PV loops change with increased preload, contractility and afterload? Cardiac output | PV loops | Frank-Starling Curve or principle
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Venous Return and Cardiac Output Curves
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What does Frank Starling’s Law mean? How’s cardiac output affected? This podcast basically answers these questions.
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In this episode, I discuss how gas exchange occurs and important laws that enable gas exchange. The two main concepts are diffusion limited gas exchange and perfusion-limited Gas exchange. In diffusion limited exchange, pressure gradient is maintained-.i.e it’s always present. In perfusion-limited gas exchange, pressure gradient is not maintained. Equilibration is reached.
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Glomerular filtration rate by Intrinsic and extrinsic mechanisms. Intrinsic mechanisms( auto regulation that involves myogenic and tubuloglomerular regulations) and extrinsic mechanisms that involve activation of the sympathetic nervous system and RAAS system through the activity of Macula Densa.
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