Metabolism Made Easy: Recent Episodes
A J Ghalayini, Ph.D.
This podcast describes selected biochemistry content that could be useful to premedical/medical students. Similar content (podcasts and videos) is available at: MEDBIOCHEM.ORG Subscribe if you 👍.
or check out my YouTube channel: Metabolism Made Easy
These podcasts and videos cover selected topics in medical biochemistry. A J Ghalayini, Ph.D.
Bio for Dr. Ghalayini:
Dr. Ghalayini received his Ph.D. in Biochemistry from the University of Houston, Houston, Texas. He has over 3 decades of experience in research and medical education as professor of biochemistry at 5 different universities.
This podcast covers 4 distinct classes of receptors and their respective hormones, including the mechanism of transducing their intracellular signals. The receptors covered in detail are the steroid receptor, the insulin receptor, and 3 distinct G-protein coupled receptors, including the second messengers they produce.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the use of glucose and ketone bodies as energy sources by the brain. During sleep and short fasts, the brain is completely dependent on the output of glucose by the liver. Glucose is oxidized all the way to CO2 by the brain under aerobic conditions to produce up to 38ATPs.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the tissue distribution of various glucose transporters and their role of glucose uptake from the bloodstream, including the regulation of one transporter (Glut-4) by insulin.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the salvage of Hypoxanthine, guanine and adenine by two important enzymes Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) and Adeneine phosphoribosyl transferase (APRT), including the outcome of an inherited deficiency in HGPRT.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the insulin-dependent uptake of glucose by GLUT-4 in muscle and adipose tissue. This insulin-dependent uptake by these tissues contributes to the reduction of plasma glucose after a meal.
Check out the link below for the video podcast:
https://youtu.be/_vyijJKL4oY
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This podcast covers the essential role of glucose as an energy source for several tissues. Most notably, red blood cells and the brain. Red blood cells are entirely dependent on glucose for their energy needs while the brain is highly dependent on glucose for its energy. Glucose in the bloodstream is produced by the liver and maintained around 80-100mg/dl during fasting to provide red blood cells and the brain with their energy needs.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the four different classes of receptors that illicit intracellular signals, including steroid receptors, ion channel receptors, receptor enzymes, and G-protein coupled receptors.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This episode summarizes the key effects on carbohydrate and lipid metabolism, including the processes that are activated by insulin and the ones inhibited by it.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast describes 4 distinct types of enzyme inhibitors and their mechanism of inhibition, including: substrate analogues, toxins, allosteric inhibitors, and heavy metals.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the regulation of pyruvate kinase allosterically and by hormone-dependent (insulin & glucagon) covalent modification. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the metabolic changes in various organs and key organ uses of the available nutrients in the bloodstream.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
With the exception of ketone bodies, the brain is entirely dependent on glucose as an energy source under most circumstances. Glucose is oxidized all the way to CO2 by the brain, producing up to 38 ATPs. This catabolism is dependent on oxygen, which is used to convert the energy in NADH and FADH2 to ATP through the Electron Transport Chain and Oxidative Phosphorylation.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the digestion of the major dietary fat, triacylglycerol, including digestion uptake into intestinal mucosa, delivery through the bloodstream, uptake and storage of fatty acids from chylomicrons in the bloodstream.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast describes the transport of ammonia produced in peripheral tissues by incorporating it into glutamine through glutamine synthase. Glutamine is transported in the bloodstream to either the liver or kidney for further metabolism.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast provides an overview of metabolic changes associated with fasting, including key metabolic changes in the liver and adipose tissue. The liver will increase its output of glucose and ketone bodies, while adipose tissue will provide fatty acids to the bloodstream for other peripheral tissues to use during fasting.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast summarizes the key biochemical components of metabolism, including: 1. definition; 2. cellular location; 3. the major catabolic pathways; 4. the 3 stages of catabolism; 5. the 12 major metabolic uses of glucose, fatty acids and amino acids; 6. the energy output of catabolism of glucose, fatty acids, and ketone bodies.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers 5 distinct enzyme regulatory mechanisms and their effects on enzyme structure and activity.
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This podcast covers the function and the location of the urea cycle, including some key features and the sequence of the enzymes as well as their location.
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This podcast covers the role of transaminases the initial step in the degradation of amino acids. This includes the role of glutamate dehydrogenase in producing ammonia. The ammonia and aspartate produced are then able to enter the urea cycle in the liver.
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This podcast covers the role of adipocytes in energy storage and their role in initiating lypolysis of stored triacylglycerols to provide various tissues with fatty acids as a energy source. The role of fatty acid Beta-oxidation in providing energy from both dietary or stored triacylglycerols is also covered.
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This podcast covers the details of the conversion of lactate produced during exercise to glucose in the liver and ultimately releasing it to the bloodstream.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/messageSupport this podcast: https://podcasters.spotify.com/pod/show/a-j-ghalayini/support
This pocast covers the regulation of the Rate-limiting enzyme in fatty acid synthesis, Acetyl CoA Carboxylase allosterically, and by covalent modification.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/messageSupport this podcast: https://podcasters.spotify.com/pod/show/a-j-ghalayini/support
This podcast covers the regulation of HMG CoA Reductase by hormones, covalent modification, cytoplasmic cholesterol, and statins.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/messageSupport this podcast: https://podcasters.spotify.com/pod/show/a-j-ghalayini/support
This podcast defines metabolism and its two distinct components: anabolism and catabolism. The major compartments involved in both are also covered. If you like this podcast, feel free to donate to the podcast.--- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/messageSupport this podcast: https://podcasters.spotify.com/pod/show/a-j-ghalayini/support
This podcast covers the distinct uses of glucose, fatty acids, and amino acids and their unique roles in metabolism. --- Send in a voice message: https://podcasters.spotify.com/pod/show/a-j-ghalayini/message
This podcast covers the key role of the liver and adipose tissue in providing energy sources to the plasma during fasting. The liver is the provider of glucose and fatty acids, while adipose tissue provides fatty acids to the bloodstream.--- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
While following a ketogenic diet, maintenance of plasma glucose is essential for several tissues. The amino acids derived from dietary proteins will provide the carbon skeletons for glucose synthesis by the liver, while the triacylglycerols from dietary fat will provide the energy for various tissues through Beta-oxidation of fatty acids.--- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast covers the production of cAMP by activation of either the beta-adrenergic receptor or the glucagon receptor as well as the activation of the alpha1-adrenergic by epinephrine to produce IP3, DG and calcium.--- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast covers the 3 stages of catabolism from the intestinal lumen to inside the cell. The energy output is mostly produced in the mitochondrial catabolic pathways. Similar content is available at: https://medbiochem.org/--- Send in a voice message: https://anchor.fm/a-j-ghalayini/messageSupport this podcast: https://anchor.fm/a-j-ghalayini/support
This podcast covers the major pathways for catabolism of glucose and fatty acids, including the ATP output from their complete degradation to CO2. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG --- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast covers the target enzymes of NSAIDS and cortisol and their respective effects on inflammation. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG --- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast covers the effect of phophorylstion/dephosphorylation by protein kinases and phosphatases on enzyme activity. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG --- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast covers the activation of the Insulin receptor resulting in activation of an intracellular protein phosphatase. The deposphorylation of eight enzymes is also covered. This dephosphorylation results in profound effects on carbohydrate, lipid and protein metabolism.--- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast describes the key tissue effects of insulin in the well-fed state including its effects on liver, muscle and adipose tissue. Also covered are the effects of insulin on regulating key enzymes involved in carbohydrate and lipid metabolism. Similar content is available at:MEDBIOCHEM.ORG--- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast describes the digestion, reassembly, absorption and storage of dietary Triacylglycerol including the role of pancreatic lipase and lipoprotein lipase. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG --- Send in a voice message: https://anchor.fm/a-j-ghalayini/message
This podcast describes the liver output of glucose during fasting and its regulation by glucagon. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the phosphorylation of enzymes by protein kinases that modify specific hydroxyl residues in enzymes. This content may be useful to premedical and medical students. Similar biochemistry content is available at: MEDBIOCHEM.ORG
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This podcast describes the specific mechanism by which statins reduce plasma cholesterol. The reduction of cholesterol synthesis by statins in effect, will result in the upregulation of the LDL receptor and increased uptake of LDL from plasma. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the specific metabolic effects of insulin on liver, muscle and adipose tissue. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the key components of the adenylate cyclase system including receptor activation, G-protein involved, activation of adenylate cyclase , production of cAMP, activation of PKA and termination of the actions of cAMP . Also included is a historical perspective of the discovery of G-proteins the adeylate cyclase system.
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This podcast describes the activation of the a phosphoprotein phosphatase by insulin. Also check out the podcast below for insulin's effects on specific enzymes: https://anchor.fm/a-j-ghalayini/episodes/Insulin-and-Enzyme-Dephosphorylation-e1mb74a
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This podcast covers key enzymes in carbohydrate and lipid metabolism the are phosphorylated by either PKA or AMP kinase and the outcone of phosphorylation on enzyme activity.
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This podcast describes the effect of cortisol on eicosanoid biosynthesis and its resulting anti-inflammatory effects. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the outcome of dephosphorylation of key enzymes trigerred by Insulin binding to its receptor and resulting in changes of both carbohydrate and lipid metabolism. Also check out my Insulin playlist on YouTube below for additional videos: INSULIN: https://www.youtube.com/playlist?list=PLXy2KYiCd9rlWs3TxwuMk26ncmzva3PM3. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers in the detail the actions of phospholipase C starting with receptor activation, activation of Gq, production of second messengers and activation of PKC. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG Biochemistry by Metabolism Made Easy playlist on YouTube: https://www.youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn
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This podcast covers the only 2 enzymes that require Vitamin B12 . This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the 4 enzymes requiring thiamine as a coenzyme. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the carbon skeletons derived from amino acids and their classification as glucogenic or ketogenic. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the major sources of NADPH and its primary uses in 5 biological reactions. This content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the regulation of acetyl CoA Carboxylase allosterically and by covalent modification. The effect of malonyl CoA on beta oxidation of fatty acids is also described. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the molecules that can produce acetyl CoA as well as the possible metabolic fates of acetyl CoA. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast is an overview of the components of metabolism, namely, catabolism and anabolism and their respective cellular functions. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the purine salvage pathway and the inherited deficiency in the salvage of hypoxanthine and guanine (HGPRT) and its outcome in infants. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG.
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This podcast covers the mutual regulation of glycolysis and gluconeogenesis by allosteric regulators, thus preventing the likelihood of a futile cycle from occurring. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the underlying changes associated with insulin resistance and resulting in dyslipidemia. These changes include effects on two key lipases namely, Lipoprotein Lipase and Hormone-Sensitive Lipase. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes one of the key outcomes of insulin resistance, hyperglycemia, including the specific tissue contributions to the rise in plasma glucose. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the underlying changes associated with insulin resistance and its consequences in both plasma and target tissues. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast is a summary of the biosynthesis of non-essential amino acids from their respective carbon skeletons. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the signals for insulin secretion by the pancreas and the molecular mechanism behind its secretion by the islets of Langerhans beta cells. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the role of cytosolic citrate in regulating glycolysis, fatty acid synthesis and providing thd vehicle to transport Acetyl CoA to the cytoplasm where it is needed for lipid synthesis. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the fifth unique liver function in its ability to detoxify organic molecules by making them more water soluble. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the role of the Urea cycle in detoxifying ammonia as the fifth unique function of the liver. This biochemistry content may be useful to premedical and medical students.Similar content is available at:MEDBIOCHEM.ORG
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This podcast describes the unique ability of the liver to synthesize ketone bodies in the mitochondria from Acetyl CoA during fasting. The ketone bodies thus produced can provide an alternative energy source to multiple peripheral tissue including the brain, but excluding the liver. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG -Check out my YouTube channel : https://youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn
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This podcast describes the second unique role of the liver in cholesterol biosynthesis, storage and uptake of LDL from plasma. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG Check out my YouTube playlist:https://youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn
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This podcast describes the unique function of the liver in producing glucose during fasting. The liver restores blood glucose through two coordinated processes, glycogenolysis and gluconeogenesis. The podcast also covers the key regulation of both processes by glucagon/epinephrine. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers 5 unique functions that are either exclusive to the liver, or occur mostly in the liver. These functions include: glucose production, cholesterol synthesis, ketone bodies synthesis, the Urea cycle and detoxification of organic molecules. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the key features of hormone-sensirive lipase and its activation by the beta-adrenergic receptor in adipose tissue during fasting. This biochemistry content may be useful to premedical and medical students. Similar content is available at:MEDBIOCHEM.ORG or check out my YouTube channel Metabolism Made Easy: https://youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn
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This podcast covers 3 key features of Lipoprotein Lipase including its location, unique function and upregulation by insulin. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the mechanism of action of Statins and how they are able to reduce plasma cholesterol. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the role of glutamine in detoxifying ammonia produced in peripheral tissues and its transport in the bloodstream for further metabolism and/or disposal of ammonia. This biochemistry content may be useful to premedical and medical students. Similar content is available at:MEDBIOCHEM.ORG
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This pocast covers the metabolism of alanine, glutamate and aspartate and the carbon skeletons they produce, in addition to their input of nitrogen to the Urea cycle. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG. You can check out my playlist on YouTube for additional videos. Metabolism Made Easy: https://www.youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn
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This podcast describes the sources of nitrogen that enter the Urea cycle including the role of 3 enzymes (ALT, AST, GDH) in collecting nitrogen from amino acid metabolism. The role of Glutamate as a sink for nitrogen is also covered. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG or YouTube channel: Metabolism Made Easy.
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This podcast describes some of the key features of the essential amino acid methionine, as well as, the role of vitamin B12 and folic acid in its resynthesis from homocysteine. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast defines and describes the use of ketogenic and glucogenic carbon skeletons derived from amino acids. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG or Check out my YouTube channel: Metabolism Made Easy.
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This podcasts explains why glucose cannot be made from fatty acid beta oxidation products i.e. Acetyl CoA. Exceptions to this concept are also included. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes protein degradation and some of the signals that target cellular proteins for proteolysis. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes 4 types of important lipases with unique locations and functions. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the strategy of targeting 3 enzymes in nucleotide biosynthesis by chemotherapy drugs. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the composition, digestion and reassembly of triacylglycerol from the diet. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast provides a simple approach for creating and organizing an effective in class or online presentation.
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This podcast describes the key metabolic effects of insulin and glucagon in various tissues. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the basics of writing and organizing a research grant proposal in the life sciences.
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This podcast describes the synthesis of eicosanoids from arachidonic acid as well as their key roles in inflammation. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the synthesis of leukotrienes from arachidonic acid and their role in hypersensitivity reactions. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast describes the two different eicosanoids derived from linoleic acid and linolenic acid, respectively and their relative effects in in the inflammatory response. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the two major eicosanoids prostacyclin and thromboxzne A2 and their role in the maintenance of vascular health. The role of Aspirin in vascular health is also covered. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the regulation of HMG CoA reductase by hormones, cholesterol and statins. This biochemistry content may be useful to premedical and medical students.
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This podcast summarizes the steps of cholesterol biosynthesis starting with acetyl CoA as the precursor. This biochemistry content may be useful to premedical and medical students.
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This podcast summarizes the key features about cholesterol including dietary intake, biosynthesis and key roles in normal cellular and tissue functions. This biochemistry content may be useful to premedical and medical students.
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This podcast covers 5 key questions to ask that will help students organize intermediary metabolic pathways. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the two signals that terminate the effects of cAMP following receptor activation. This biochemistry content may be useful to premedical and medical students.
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This podcast defines the term, fat and addresses 5 myths about our understanding and perception of fat in the diet. This biochemistry content may be useful to premedical and medical students.
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This podcast summarizes the key metabolic effects of Insulin and Glucagon in various tissues. This biochemistry content may be useful to premedical and medical students.
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This podcast covers 5 important questions to ask about glycolysis that could be helpful in organizing the pathway (and other pathways), while focusing on key information about the pathway. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the inhibitors, uncouplers, adnenine nucleotide translocase inhibitors, the effect of hypoxia, as well as the regulation of the Electron Transport Chain. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the complexes of the Electron Transport Chain, the flow of electrons, the enzymes involved and the synthesis of ATP at complex V. This biochemistry content may be useful to premedical and medical students.
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This episode covers the role of the Electron Transport Chain in coverting high energy molecules into usable energy in the form of ATP. This biochemistry content may be useful to premedical and medical students.
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This podcasts covers the 4 possible fates of pyruvate. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the total energy output from glycolysis, pyruvate dehydrogenase and the TCA cycle starting with glucose. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the regulation of the cycle and other key regulatory roles of citrate. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the enzymes in the TCA cycle and its energy output. This biochemistry content may be useful to premedical and medical students.
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This podcasts covers the major fuel stores (reserves) available during fasting. This biochemistry content may be useful to premedical and medical students.
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This podcast covers lactate dehydrogenase and lactic acidosis. This biochemistry content may be useful to premedical and medical students.
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This podcast covers pyruvate dehydrogenase deficiency and thiamine deficiency clinical outcomes. This biochemistry content may be useful to premedical and medical students.
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This episode covers pyruvate dehydrogenase, coenzyme requirements and its regulation in detail. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the regulation of the Urea cycle, the detoxification of ammonia in peripheral tissues as well as some important clinical correlates. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the steps in the Urea cycles including the sources of nitrogens that enter the cycle. This biochemistry content may be useful to premedical and medical students.
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This episode covers the regulation of pyruvate kinase and the effect of enzyme deficiency on red blood cells. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the activation of the alpha1-adrenergic receptor and the production of the second messengers DAG, IP3 and calcium. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the activation of the beta-adrenergic receptor and the generation of the second messenger, cAMP in detail. This biochemistry content may be useful to premedical and medical students.
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This podcast provides an overview of G-protein coupled recertors (GPCRs) and Second messengers. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the activation of receptors tyrosine kinase receptors. This biochemistry content may be useful to medical and premedical students.
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This podcast describes the mechanism of action of steroid receptors and the types of cellular responses they ellicit. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the 4 types of receptors involved in cellular signaling. This biochemistry content may be useful to premedical and medical students.
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This podcasts describes the various types of enzyme inhibition with some specific examples. This biochemistry content may be useful to premedical and medical students.
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This podcast summarizes the major types of enzyme regulatory mechanisms. This biochemistry content may be useful to premedical and medical students.
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This podcasts covers the major reactions where tetrahydrofolate and B 12 are needed. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the packaging and disposal of ammonia. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the glutamate dehydrogenase reaction and its regulation. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the effect of alcohol metabolism on depleting important gluconeogenic intermediates, namely, pyruvate, oxaloacetate and Glyceradehye 3-P by a rise in NADH. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG
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This podcast covers the reaction details and regulation of the aminotransferases ALT and AST. This biochemistry content may be useful to premedical and medical students.
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This podcast provides an overview of protein digestion in the small intestine including the mechanism of activation of zymogens. An introduction to transaminases is also covered. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the major nutrients in the diet and their overall catabolism to produce energy. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the latter steps of gluconeogenesis and covers the key regulatory molecules of the pathway. This biochemistry content may be useful to premedical and medical students.
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This podcasts covers the key bypass steps in gluconeogenesis and their regulation (part I). This biochemistry content may be useful to premedical and medical students.
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This podcast describes the biosyhthesis of pyrimidenes and summarizes some of the cancer therapeutic strategies targeting nucleotide biosynthesis. This biochemistry content may be useful to premedical and medical students.
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This podcasts describes some of the key features of purine biosynthesis including important therapeutic strategies for disrupting nucleotide synthesis. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the key metabolic changes in various organs during the fasting state. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the major metabolic changes associated with the various organs during the well-fed state. This biochemistry content may be useful for premedical and medical students.
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This podcast covers the last 6 steps in glycolysis from Aldolase A to Lactate dehydrogenase. Key regulation of the entire pathway is also covered. This biochemistry content may be useful to premed and medical students.
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This podcast describes the regulation of phosphofructokinase-1 (PFK1) in some detail and its allosteric activation by fructose 2, 6 -bis- phosphate. This biochemistry content might be useful to premedical and medical students.
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This podcast describes the first step in glycolysis and covers the properties of the two isozymes hexokinase and glucokinase in some detail. This biochemistry content might be useful to premedical and medical students.
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This podcast presents an overview of glycolysis including some tissue specific aspects of the pathway. This biochemistry content may be useful for premed and medical students.
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This podcast describes the key features and tissue distribution of the various types of glucose transporters. This biochemistry content may be useful to premed and medical students.
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This podcast describes the metabolic processes responsible for maintenance of normal glucose levels in the plasma. This biochemistry content may be useful to premed and medical students.
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This podcast covers thd mechanism of activation of two GPCRs: The beta- adrenergic and the alpha1-adrenergic receptors. This biochemistry content may be useful to premedical and medical students.
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This podcast covers the four major classes of receptors and their mechanism of activation to generate a cellular response. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the activation of the glucagon receptor and some of its key metabolic effects. This biochemistry content may be useful to premedical and medical students.
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This podcast summarizes the key metabolic effects of glucagon. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the major metabolic effects of insulin in various tissues. This biochemistry content may be useful to premedical and medical students.
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This podcast describes the activation of the Insulin receptor and some of the cellular responses associated with insulin binding to its receptor.
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This podcast briefly describes the synthesis and function of ketone bodies.
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The podcast describes the secretion and synthesis of insulin by the pancreas.
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This podcast covers select biochemistry content topics that could be useful to premedical and medical students. If you like this podcast, please subscribe. For additional related podcasts and videos, please visit: MEDBIOCHEM.ORG or check out my YouTube channel: Metabolism Made Easy https://youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn Follow me on Twitter: @DrAJGhalayini
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