Reducing excessive daytime sleepiness (EDS) is an important treatment goal for patients with narcolepsy or obstructive sleep apnea (OSA). In order to achieve reduced EDS, cataplexy and sleep paralysis/hypnagogic hallucinations must be controlled to improve disturbed nighttime sleep, which then improves fatigue and brain fog and reduces psychosocial dysfunction, therefore improving quality of life (QoL). The latest efficacy and safety data should be reviewed, and considerations for treatment selection –especially in refractory patients, children, the elderly, or pregnant patients –must be taken into account.
This CMEOCast podcast focuses on developing personalized, effective strategies to reduce EDS in patients with OSA or narcolepsy, including an overview of data on incorporating the use of safer, lower sodium alternatives to mitigate EDS without imposing cardiovascular burden.
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The neurobiology of excessive daytime sleepiness (EDS) in obstructive sleep apnea (OSA) has no identified pathophysiology. This can make it difficult for clinicians to determine a target for therapeutic intervention; therefore, awareness of the mechanisms of action of current and novel therapies is vital when selecting an optimal treatment.
In the second episode of this CME Outfitters podcast series on EDS, expert faculty will focus on identifying key neurotransmitters involved in the sleep-wake cycle and recognizing how therapies targeted to those key neurotransmitters exert their therapeutic effect on EDS in narcolepsy and OSA.
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