Science: Recent Episodes
None
Scientists are racing to conserve what remains of these majestic animals’ genetic diversity
Efficient navigation requires prioritizing information from behaviorally relevant locations. In rats, such selective sampling may arise from theta-paced sweeps in grid and place cell populations, which scan nearby space in a left-right alternating ...
American bison (Bison bison) were nearly hunted to extinction by the 20th century. This rapid decline and the fragmented nature of remnant populations pose challenges to their recovery and resilience, as does human-facilitated admixture between bison ...
Many important biological functions arise not from single genes but from complex interactions encoded by entire genomes. We report the first generative design of complete bacteriophage genomes using genome language models. We generated viable ...
Candida auris is a multidrug-resistant fungus of major public health concern whose mechanisms for persistence on skin, a major risk factor for deadly outbreaks, remain unclear. In this study, we compared skin colonization by C. auris versus C. albicans ...
Global policy around climate and nature goals has evolved considerably over the last decade. Today, countries recognize that climate and biodiversity crises are profoundly interconnected, and that one cannot be solved without addressing the other. Elevating biodiversity and ecosystem collapse to the same geopolitical urgency as climate change is largely due to the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES). As the platform enters its second decade, and with the Convention on Biological Diversity Subsidiary Body on Implementation meeting in Nairobi this month to assess progress toward implementation of the Kunming-Montreal Global Biodiversity Framework (KM-GBF), focus will be on how countries integrate IPBES assessment findings into their national policy and legislation frameworks, planning, and national budgets for a truly deep societal and institutional transformation.
The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities of the microtubule-based molecular motors kinesin and dynein. The mechanism for switching between these two opposite-polarity ...
Mucus is known as a viscous fluid; yet, snails manufacture various mucus-based materials with much higher cohesion and tailored to different and even antagonistic functions, including lubrication, adhesion, protection, and defense. To gain insight into ...
Internal combustion engine (ICE) vehicles represent the single largest source of carbon dioxide emissions for most US households. Although battery electric vehicles (BEVs) considerably reduce use-phase emissions, the transition poses a fundamental life ...
What did our ancestors eat? Current understanding of diet in human evolution is predicated on abundant animal foods and mastery of fire, both unlikely for early hominins. Using multiple lines of evidence, including the metabolic requirements of an ...
Global plastic production has more than doubled since 2000 to roughly 460 million tonnes per year, about half of it destined for single-use products (1). After accounting for reprocessing losses, only about 9% of plastic waste is ultimately recycled, whereas nearly half is landfilled, about a fifth is incinerated, and the rest is mismanaged or leaks into ecosystems (1, 2). As governments negotiate a legally binding global plastics treaty (3, 4), they should recognize that recycling alone cannot solve plastic pollution and prioritize reducing production and reusing materials.
On 8 June, Brazil temporarily suspended its Butantan-DV dengue vaccination rollout after reports of rare and unexpected adverse events during early implementation (1–3). This decision—an appropriate response to a safety signal—should not be interpreted as evidence that dengue vaccination has failed. Rather, it serves as a call to make dengue vaccine deployment more scientifically accountable. Every dengue vaccine rollout should be paired with active pharmacovigilance, transparent reporting, and postlicensure studies that can distinguish vaccine-related adverse events from severe dengue occurring after vaccination. The priority is not to retreat from dengue vaccination but to ensure that safety, effectiveness, and serotype-specific performance are monitored in real time.
AffiliationsScience6 Aug 2026Vol 393, Issue 6811p. 571DOI: 10.1126/science.aek2112 PREVIOUS ARTICLEChange comes for science publishing paradigmsPreviousNEXT ARTICLEDengue vaccines need long-term…
A pair of insiders cast recent efforts to increase access to research as problems, not progress
Extreme examples of environmental harm feature prominently in a writer’s indictment of industrial extraction
New approaches to evaluating progress of AI should be built around diversity, partnership, and systemicity
Candida auris represses host antifungal defense to establish a favorable cutaneous niche
The generation of functional viral genomes has urgent biosafety and biosecurity implications
A network of seismometers measured atmospheric turbulence during Hurricane Isaac’s landfall
In an unstable geopolitical environment, countries are looking to secure access to artificial intelligence (AI) capabilities, which are seen as essential to economic growth, scientific research, and national security. Few have placed sovereignty as ...
Trial failed of supposedly potent antibodies that the leading vaccine candidates aim to trigger
New science may explain mysterious gap before oxygen flooded our planet billions of years ago
A remote mining town gripped by fear saw hundreds of suspected cases before the government declared an outbreak, report says
Vague language and extensive reviews could impede potentially useful research, some scientists fear
In organic chemistry, functionalization of two adjacent carbons often starts from alkenes or already disubstituted precursors. Here, we report an exergonic activation mode that directly generates alkene radical cation intermediates from monofunctional C(...
The identification of the cancer cell of origin is a fundamental issue in cancer biology. We used fluorescent lineage tracing of independent mouse skin stem cell populations, single-cell transcriptomics, and duplex sequencing to identify the origin of ...
Japanese botanist Kenji Suetsugu studies plants that steal carbon and nutrients from soil fungi
Antimicrobial drugs changed everything, but misuse and resistance have been constant companions
HomeScienceVol. 390, No. 6769EU’s global investments put biodiversity at riskBack To Vol. 390, No. 6769 Full accessLetter Share on EU’s global investments put biodiversity at riskClara Grilo, Pedro Beja, [...] , Joana Bernardino, Nuno Ferrand, [...] , William F. Laurance, and Anthony P. Clevenger+3 authors +1 authors fewerAuthors Info & AffiliationsScience9 Oct 2025Vol 390, Issue 6769p. 138DOI: 1…
For nearly three decades, the Conference of the Parties (COP) of the United Nations Framework Convention on Climate Change has convened global leaders, policy-makers, and scientists—at considerable cost, including a hefty environmental footprint—to confront one of humanity’s greatest existential threats: climate change. Milestones achieved at prior COPs such as the Kyoto Protocol, the Paris Agreement, and the Glasgow Climate Pact provided optimism and guidance, yet rhetoric has often eclipsed action. Pledges and targets proliferate, and new frameworks may recycle old goals, weakening meaningful change. Meanwhile, challenges facing fundamental needs such as food production are mounting. Weather shocks, growing populations, loss of biodiversity, and conflicts combine to form a perfect storm that amplifies food and nutrition insecurity, migration, and instability.
Astronomical surveys have identified numerous exoplanets with bulk compositions that are unlike the planets of the Solar System, including rocky super-Earths and gas-enveloped sub-Neptunes. Observing the atmospheres of these objects provides information ...
Cytosolic nucleic acid–sensing pathways are potential targets for cancer immunotherapy. Although stimulator of interferon genes (STING) agonists have shown substantial antitumor effects in animal models, their clinical efficacy in human tumors remains ...
A DNA repair function in a cytosolic sensor demonstrates a potential role in naked mole-rat longevity
Last month at the 80th session of the United Nations, the call to be “better together” was especially appropriate for discussions on the Early Warnings for All global initiative. About half the world’s countries now have multihazard weather alert systems,...
Microbes, immune cells, and enterocytes interact to regulate the intake of lipids in the mouse gut
Bacteria undergo rapid genetic changes that are selected by alterations in the human gut environment
Legislation proposals seek to bring certainty, clarification, harmonization, and simplification
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that naked mole-rat cyclic guanosine monophosphate–adenosine ...
Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, we conducted sequential CRISPR screens to identify ...
The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A linked plasma membrane (PM) cholesterol availability in ...
Understanding how genetic variation translates into complex phenotypes remains a fundamental challenge. In this work, we address this by mapping genome-to-proteome relationships in 800 progeny of a cross between two yeast strains adapted to distinct ...
Long interspersed nuclear element–1 (LINE-1 or L1), the only autonomously active retrotransposon in humans today, constitutes a large proportion of the genome and continues to evolve the genome and impact fundamental biological processes. L1 ...
Diversity-generating retroelements (DGRs) accelerate evolution by rapidly diversifying variable proteins. The human gastrointestinal microbiota harbors the greatest density of DGRs known in nature, suggesting that they play adaptive roles in this ...
In their Editorial “Rewiring science diplomacy” (21 August, 10.1126/science.aeb4815), V. C. Turekian and P. Gluckman offer a timely framework for rethinking science diplomacy in an era of renewed geopolitical competition. However, describing earlier efforts as merely “aspirational” risks underestimating their strategic value, and overemphasizing transactionalism could undermine the foundations of international cooperation.
In their Editorial “Rewiring science diplomacy” (21 August, 10.1126/science.aeb4815), V. C. Turekian and P. Gluckman argue that science diplomacy efforts must include a transactional approach to remain relevant and suggest that advancing national interest is a new feature of science diplomacy. We disagree.
Transcriptional initiation and termination decisions drive messenger RNA (mRNA) isoform diversity but the relationship between them remains poorly understood. By systematically profiling joint usage of transcription start and end sites, we observed that ...
Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi revealed how regulatory T cells prevent autoimmune disease
Data produced by “silicon samples” depends on researchers’ exact choice of models, prompts, and settings
NASA and India’s $1.5 billion NISAR mission promises global time lapses of the planet’s ever-changing land and ice
The theory behind carbon offset projects is appealing: Instead of an organization cutting its own emissions, it can fund lower-cost carbon-reducing projects elsewhere to “offset” its emissions. The reality has been less encouraging. Most carbon offset ...
Metal carbenes with different polarities are generated from a single class of precursor
Combining multiple neurotechnologies allows amputees to perform complex physical activities
Swapping out the brain’s immune cells can slow progression of a devastating neurological disease
HomeScienceVol. 389, No. 6756State law threatens Brazil’s high grasslandsBack To Vol. 389, No. 6756 Full accessLetter Share on State law threatens Brazil’s high grasslandsGlayson A. Bencke, Marcelo M. Madeira, [...] , Luís F. Perelló, Eduardo Vélez-Martin, [...] , Jan Karel F. Mähler Jr, Gerhard E. Overbeck, Raphael V. Zulianello Alves, João de Deus Medeiros, and Fernando Joner+6 authors +4 autho…
In February, China’s Ministry of Ecology and Environment announced a plan to eliminate severe air pollution by the end of 2025. To achieve this ambitious goal, China will tighten emission standards and boost clean energy and electric transport, including shifting freight from roads to rail and waterways (1). These strategies will build on the progress China has already made, but additional action will be needed to meet the proposed clean-air goals.
In the past two decades, the US President’s Emergency Plan for AIDS Relief (PEPFAR) has prevented millions of deaths and new HIV infections through the provision and support of HIV testing, treatment, and prevention programs in more than 50 countries worldwide (1). Although HIV remains incurable, treatment with antiretroviral therapy (ART) leads to sustained viral suppression, which halts both immune system destruction and HIV transmission (2–4). With ART delivery at its core, PEPFAR has been enormously successful in improving both individual and public health: At the end of 2024, more than 20 million people were receiving life-saving ART through PEPFAR, and between 2010 and 2023, new HIV infections were reduced by an estimated 52% in PEPFAR-supported countries (1). However, in January, the US government ordered a 90-day hold on the PEPFAR program, which was later extended to 20 May (5) and still has not been lifted. Although HIV treatment was quickly exempted from the hold (6), ART delivery has been destabilized and effectively halted in many settings (7). The US government must reinstate PEPFAR to ensure continued progress toward ending HIV as a public health threat.
Why river channels confine flow to a single pathway or divide flow into multiple interwoven pathways (threads) forms a long-standing fundamental question in river science, which to date remains poorly understood. In this study, we probed channel-pattern ...
Many symbioses involve one host species having several mutualist partners, yet theory predicts that unrelated symbionts lead to destabilizing conflict through competition for host resources. We combined isotope labeling, computed-tomography three-...
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmitochondrial antioxidant mechanisms is less well ...
The Qimmeq (Greenland sled dog) has worked continuously with the Inuit in Greenland for more than 800 years. However, they now face drastic population declines caused by climate change, urbanization, and competition from snowmobiles. This study sequenced ...
There is an urgent and growing need for transformative change to address global challenges and achieve sustainability. Yet despite mounting evidence, societal responses remain incremental, fragmented, and largely inadequate. In simple terms, we must ...
Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function and its involvement in the pathogenesis of AD derives ...
Human neurons programmed through transcription factor (TF) overexpression model neuronal differentiation and disease. However, the diversity of neuronal subtypes programmable in vitro remains unresolved. We modulated developmental signaling pathways ...
Sex chromosomes are involved in three major empirical patterns: (i) Y (or W) chromosomes are often nonrecombining and degenerate; (ii) heterogametic offspring (XY or ZW) from interspecific crosses are more often sterile or inviable compared with ...
Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and ...
Telomerase ribonucleoprotein (RNP) synthesizes telomeric repeats at chromosome ends using a telomerase reverse transcriptase (TERT) and a telomerase RNA (hTR in humans). Previous structural work showed that human telomerase is typically monomeric, ...
Lower-extremity prostheses have evolved through mechanical redesigns that prioritize improved cyclic locomotion. However, this limited approach to limb restoration has precluded necessary progress toward recovering the versatile acyclic movements that ...
Scientists, ethicists, and officials worry the OpenAI-sponsored contest sidesteps archaeological norms
“There is a lot of pressure to essentially leave the country or not pursue research,” one Ph.D. student says
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
Distributed peer review enlists more researchers in the process, but some may lack expertise
USDA research points to viruses spread by pesticide-resistant mites, indicating a worrying trend
Oriented cell divisions are crucial for determining the overall morphology and size of plants, but what controls the onset and duration of this process remains largely unknown. Here, we identified a small molecule that activates root apical meristem (RAM)...
Advances in genomics, proteomics, and metabolomics have revealed associations between specific microbiota species in health and disease. However, the precise mechanism(s) of action for many microbiota species and molecules have not been fully elucidated, ...
Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. ...
CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand
Long before the 5 November US presidential election, I had become ever more concerned that science has fallen victim to the same political divisiveness tearing at the seams of American society. This is a tragedy because science is the best—arguably the ...
Players help Darwin discover new species and develop scientific theories in a fast-paced board game
HomeScienceVol. 386, No. 6723Argentina’s unsustainable policiesBack To Vol. 386, No. 6723 Full accessLetter Share on Argentina’s unsustainable policiesSofia Capasso [email protected] and Verónica CapassoAuthors Info & AffiliationsScience14 Nov 2024Vol 386, Issue 6723pp. 735-736 PREVIOUS ARTICLEA voyage to victoryPreviousNEXT ARTICLEEnd illegal sand mining in ChinaNext NotificationsBookmark Conte…
China is the world’s largest producer and consumer of sand gravel and crushed rocks, with an annual consumption of 20 billion metric tons, accounting for nearly half of global consumption (1, 2). Sand mining activities alter riverbed and lakebed topography and disrupt aquatic habitats and river ecosystems (3). These environmental changes threaten the safety of downstream bridges, embankments, underwater structures, and flood prevention infrastructure (3). China’s Ministry of Water Resources has implemented regulations to curb sand mining, but companies continue to engage in mining activities, sometimes with the permission of local governments (4). China must take steps to streamline and enforce sand mining bans.
The final planned negotiation session of the Global Plastics Treaty will take place from 25 November to 1 December in Busan, Republic of Korea (1). Negotiators hope to provide the treaty’s future signatories with internationally, legally binding obligations that can effectively mitigate plastic pollution. Most discussions so far have focused on the largest category of plastics: packaging and single-use products (2). However, effective strategies must also address the second-largest global plastic category: building and construction materials, which accounted for 17% of plastic use in 2019 (3). Without intervention, demands for plastic building materials are projected to nearly double by 2050 to 150 million metric tonnes, a quantity that would surpass the 2019 level of plastic packaging production (4). The Global Plastics Treaty must include commitments to reduce plastics used in construction.
A few months after ChatGPT was released, the neural network pioneer Terrence Sejnowski wrote about coming to grips with the shock of what large language models (LLMs) could do: “Something is beginning to happen that was not expected even a few years ...
Republican control of Congress will help him with agency appointments and policy shifts
Scientists worry Trump will leave WHO and make deep cuts in programs that aim to control diseases worldwide
U.K. firm plans to revamp FLIP before deploying it to study air-sea interactions and how sonar beams travel
Co-authors say preliminary data on lecanemab fatalities don’t support the paper’s claims
The reelection of Donald Trump for a second, nonconsecutive term as US president—mirroring only Grover Cleveland’s 22nd and 24th presidencies after the Civil War—underscores a reality: Although his success stems partly from a willingness to tap into ...
Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic activity, but here we used chemically induced proximity to ...
Early embryogenesis is driven by transcription factors (TFs) that first activate the zygotic genome and then specify the lineages constituting the blastocyst. Although the TFs specifying the blastocyst’s lineages are well characterized, those playing ...
The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradicate cancers and ...
Building a cadre of researchers is of “vital importance” to saving the world's second largest rainforest
Concern about misinformation and its toxic effects on democracy is widespread. A survey of nearly 1500 experts by the World Economic Forum ranked misinformation and disinformation (the latter being intentionally spread, whereas the former may arise ...
Cataclysm that killed dinosaurs and shook up life on Earth likely paved the way for this mutually beneficial relationship
Last month, when the world’s most populus country, India, reported its first case of the new, highly transmissible clade Ib mpox variant, the challenge of containing the virus was once again evident. Only a few weeks before that in August, the World ...
HomeScienceVol. 386, No. 6717Welcome to the Science Olympics!Back To Vol. 386, No. 6717 Full accessLetterNextGen Voices Share on Welcome to the Science Olympics!Gheed Mukhles [email protected], Sara Shakir [email protected], [...] , Ginevra Fulco [email protected], Daniela de Angeli Dutra [email protected], [...] , Katie Burnette [email protected], Frantisek Mach [email protected], Amy Leigh Kloc…
Near-rigid-body grain rotation is commonly observed during grain growth, recrystallization, and plastic deformation in nanocrystalline materials. Despite decades of research, the dominant mechanisms underlying grain rotation remain enigmatic. We present ...
Humans have been driving a global erosion of species richness for millennia, but the consequences of past extinctions for other dimensions of biodiversity—functional and phylogenetic diversity—are poorly understood. In this work, we show that, since the ...
Loss of function of the RNA-binding protein TDP-43 (TDP-LOF) is a hallmark of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Here we describe TDP-REG, which exploits the specificity of cryptic splicing induced by TDP-LOF to ...
Clostridioides difficile infection (CDI) is an urgent public health threat with limited preventative options. In this work, we developed a messenger RNA (mRNA)–lipid nanoparticle (LNP) vaccine targeting C. difficile toxins and virulence factors. This ...
Hydrogen atom abstraction is an important elementary chemical process but is very difficult to carry out enantioselectively. We have developed catalysts, readily derived from the Cinchona alkaloid family of natural products, which can achieve this by ...
Cryptic exons enable delivery of therapies only to sick neurons in a motor neuron disease
Transformational change is possible, but design and implementation must seek to avoid lock-in
Pandemic era partisanship inspired an agency leader’s search for better conflict resolution
If approach holds up, it could “result in health benefits to millions of malnourished children worldwide,” experts say
Agency fines Cassava $40 million, and two of its employees lesser amounts, over research on simufilam
To determine how neuronal circuits encode and drive behavior, it is often necessary to measure and manipulate different aspects of neurochemical signaling in awake animals. Optogenetics and calcium sensors have paved the way for these types of studies, ...
We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene natural products that is effective against drug-sensitive and drug-resistant Plasmodium falciparum strains, blocking both asexual replication and sexual ...
Harnessing the microbiome to benefit human health requires an initial step in determining the identity and function of causative microorganisms that affect specific host physiological functions. We show a functional screen of the bacterial microbiota ...
The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including ...
Agency announces research misconduct finding for neuroscientist Eliezer Masliah as scores of his papers fall under suspicion
The possibility that National Institute on Aging neuroscience chief Eliezer Masliah doctored images in scientific writings for decades is likely to provoke anxiety among multiple drug companies. The concerns recently documented in a dossier on more than 100 of his papers most directly challenge an experimental Parkinson’s disease therapy developed by Prothena (see main story, p. 1406). But 238 active patents concerning neurological conditions also cite suspect work noted in the dossier, according to data from Dimensions Analytics. And the corporate holders of those patents include dozens of firms at work on treatments.
Rare epithelial cells in our airways initiate reflexes to guard against harmful stimuli
A single neuronal population in the spinal cord is crucial to restore walking after paralysis
HomeScienceVol. 385, No. 6716Criminal activity in Nigeria’s protected areasBack To Vol. 385, No. 6716 Full accessLetter Share on Criminal activity in Nigeria’s protected areasJames Kehinde Omifolaji, Sunday Opeyemi Adedoyin, and Tauheed Ullah Khan [email protected]Authors Info & AffiliationsScience26 Sep 2024Vol 385, Issue 6716p. 1427DOI: 10.1126/science.adr3739 PREVIOUS ARTICLEIndia’s Nicobar pl…
HomeScienceVol. 385, No. 6716Hajj pilgrims suffer from climate extremesBack To Vol. 385, No. 6716 Full accessLetter Share on Hajj pilgrims suffer from climate extremesMilad HaghaniAuthors Info & AffiliationsScience26 Sep 2024Vol 385, Issue 6716p. 1426DOI: 10.1126/science.adr2696 PREVIOUS ARTICLEVirtual You: How Building Your Digital Twin Will Revolutionize Medicine and Change Your LifePreviousNEX…
India’s Andaman and Nicobar Islands territory, which comprises 836 mostly uninhabited islands between the Bay of Bengal and the Andaman Sea, is a global biodiversity hotspot. Forest covers about 82% of the islands’ total geographic area (1). In March 2022, India sanctioned a development plan for the southern tip of the Great Nicobar Islands, which, if implemented, would cause habitat loss and fragmentation, possibly leading to species extinctions and behavioral changes, as well as the spread of invasive species (2). India must safeguard the islands’ biodiversity and culture from exploitation by infrastructure development.
Does the information that people see on social media influence their political views? Is it making people politically more divided? In July 2023, Science published three papers on an unprecedented study of the effects of social media and social media ...
The recent capability to measure thousands of plasma proteins from a tiny blood sample has provided a new dimension of expansive data that can advance our understanding of human health. For example, the company SomaLogic has developed the means to ...
HomeScienceVol. 385, No. 6716Virtual You: How Building Your Digital Twin Will Revolutionize Medicine and Change Your LifeBack To Vol. 385, No. 6716 Full accessBooks et al.Podcast Share on Virtual You: How Building Your Digital Twin Will Revolutionize Medicine and Change Your LifeScience26 Sep 2024Vol 385, Issue 6716p. 1425DOI: 10.1126/science.ads7922 PREVIOUS ARTICLEA little care before we leapPr…
Common in people living at great elevations, a type of bacterium reduces damage caused by low oxygen levels
Opioids are widely used, effective analgesics to manage severe acute and chronic pain, although they have recently come under scrutiny because of epidemic levels of abuse. While these compounds act on numerous central and peripheral pain pathways, the ...
Genetically modified (GM) crops have been adopted by some of the world’s leading agricultural nations, but the full extent of their environmental impact remains largely unknown. Although concerns regarding the direct environmental effects of GM crops ...
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic ...
Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that catalyze the acquisition of complex chromosomal rearrangements present in cancer. Micronuclei are characterized by persistent DNA damage and catastrophic nuclear ...
The Swan Islands, three remote islands in the Caribbean Sea, are home to several endemic species. In 1991, the islands were designated as the Abogado Agustín Córdoba Rodríguez Marine National Park (1). However, the Honduran Naval Force has custody of the islands (1), and researchers are often denied access to them (2). The Honduran government is now moving forward with plans to establish a correctional facility for prisoners within the park’s borders on Great Swan Island (3, 4), putting endemic species at risk.
HomeScienceVol. 385, No. 6712Protect Oman’s Masirah Island Arabian gazelleBack To Vol. 385, No. 6712 Full accessLetter Share on Protect Oman’s Masirah Island Arabian gazelleAsila S. Al Naabi [email protected], Bushra A. Al Kindi, and Antoine O. H. C. LeducAuthors Info & AffiliationsScience29 Aug 2024Vol 385, Issue 6712p. 942DOI: 10.1126/science.adq2518 PREVIOUS ARTICLESafeguard the endemic specie…
HomeScienceVol. 385, No. 6712Moroccan cannabis farms threaten biodiversityBack To Vol. 385, No. 6712 Full accessLetter Share on Moroccan cannabis farms threaten biodiversityBrahim Chergui, Soumia Fahd, [...] , Xavier Santos, and Juli G. Pausas [email protected]+1 authors fewerAuthors Info & AffiliationsScience29 Aug 2024Vol 385, Issue 6712p. 941DOI: 10.1126/science.adq5140 PREVIOUS ARTICLEClimate…
HomeScienceVol. 385, No. 6712Climate Capitalism: Winning the Race to Zero Emissions and Solving the Crisis of Our AgeBack To Vol. 385, No. 6712 Full accessBooks et al.Podcast Share on Climate Capitalism: Winning the Race to Zero Emissions and Solving the Crisis of Our AgeScience29 Aug 2024Vol 385, Issue 6712p. 940DOI: 10.1126/science.adr9659 PREVIOUS ARTICLEThe dawn of climate securityPreviousNEX…
An accommodating and supportive environment is essential to conducting scientific research. Yet, in almost every country, researchers can experience harassment, threats, prosecution, or even violence for opinions they express or for their work in ...
Manipulation of neural circuits targeted by morphine enables pain relief without opioids
Recent respiratory outbreaks have garnered substantial attention, yet most respiratory monitoring remains confined to physical signals. Exhaled breath condensate (EBC) harbors rich molecular information that could unveil diverse insights into an ...
After leaving the Sun’s corona, the solar wind continues to accelerate and cools, but more slowly than expected for a freely expanding adiabatic gas. Alfvén waves are perturbations of the interplanetary magnetic field that transport energy. We use in ...
Dryland expansion causes widespread water scarcity and biodiversity loss. Although the drying influence of global warming is well established, the role of existing drylands in their own expansion is relatively unknown. In this work, by tracking the air ...
“Deepfakes” refers to the use of digital technology, particularly artificial intelligence, to fabricate media—typically videos but also images and audio—that appear to be real. For example, a person's face can be superimposed onto another’s body, ...
Critics says the new Frontiers Planet Prize for research to keep Earth habitable perpetuates old inequities
Scientists are teasing out the benefits of intercropping, but getting the right mix of plants is key
Researchers say 6000-year-old Iberian Peninsula megalith required sophisticated knowledge of physics, geometry, and geology
Spindle bipolarization, the process of a microtubule mass transforming into a bipolar spindle, is a prerequisite for accurate chromosome segregation. In contrast to mitotic cells, the process and mechanism of spindle bipolarization in human oocytes ...
In this Review, we explore the transformative potential of decentralized clinical trials (DCTs) in addressing the limitations of traditional randomized controlled trials (RCTs). We highlight the merits of DCTs fostering greater inclusivity, efficiency, ...
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indoleamine-2,3-dioxygenase 1 (IDO1), which metabolizes ...
We present an algorithm to estimate the excited states of a quantum system by variational Monte Carlo, which has no free parameters and requires no orthogonalization of the states, instead transforming the problem into that of finding the ground state of ...
Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and presynapses, but how membrane proteins are internalized along the axon shaft remains unclear. We focused on clathrin-coated structures and endocytosis along the axon ...
Ever since the Cass Review was released in April—an evaluation by the United Kingdom’s National Health Service that has led to a ban on pubertysuppressing medication for transgender and gender diverse (TGD) youth—there has been criticism of the ...
When it comes to making decisions about artificial intelligence (AI), Eric Schmidt is very clear. In 2023, the former Google CEO told NBC’s Meet the Press, “there’s no way a nonindustry person can understand what is possible. It’s just too new, too hard, ...
Effective fisheries management requires accurate estimates of stock biomass and trends; yet, assumptions in stock assessment models generate high levels of uncertainty and error. For 230 fisheries worldwide, we contrasted stock biomass estimates at the ...
Wind energy is helping to decarbonize the electrical grid, but wind blades are not recyclable, and current end-of-life management strategies are not sustainable. To address the material recyclability challenges in sustainable energy infrastructure, we ...
Samarium diiodide (SmI2) is a privileged, single-electron reductant deployed in diverse synthetic settings. However, generalizable methods for catalytic turnover remain elusive because of the well-known challenge associated with cleaving strong SmIII–O ...
In 2023, creativity became the second-most in-demand skill, after analytical thinking, across industries (1), reflecting the increasingly complex challenges faced by organizations and individuals. The teaching of creativity has been integrated into higher education in the arts (2), business (3), and engineering (4). Creativity should also be taught in basic science programs.
Forests provide ecological, economic, social, and aesthetic benefits. India is second only to Brazil in forest loss resulting from deforestation (1). To compensate for this loss, the Indian government supports and funds large-scale tree-planting initiatives and has implemented market-based credit programs. However, planting trees cannot replicate the benefits of natural forests, and market-based approaches have shown limited success (2). India should focus on protecting rather than recreating forests.
HomeScienceVol. 385, No. 6711Mangrove restoration in China’s tidal ecosystemsBack To Vol. 385, No. 6711 Full accessLetter Share on Mangrove restoration in China’s tidal ecosystemsXiaoguang Ouyang [email protected], Fen Guo, [...] , Shing Yip Lee, and Zhifeng Yang+1 authors fewerAuthors Info & AffiliationsScience22 Aug 2024Vol 385, Issue 6711p. 836DOI: 10.1126/science.adq0220 PREVIOUS ARTICLEBold …
A lyrical ode to Earth’s geologic landscapes invites readers to ponder our place in the cosmos
New variants keep eluding human immunity but hospitalizations and deaths are far below earlier peaks
Bluetongue spreads rapidly in sheep and cattle in six countries despite the use of three new vaccines
Software trained to identify fences from aerial images could help wildlife managers prevent pronghorn from getting stuck and starving
Spontaneous activity refines neural connectivity prior to the onset of sensory experience, but it remains unclear how such activity instructs axonal connectivity with subcellular precision. We simultaneously measured spontaneous retinal waves and the ...
Memories are dynamic constructs whose properties change with time and experience. The biological mechanisms underpinning these dynamics remain elusive, particularly concerning how shifts in the composition of memory-encoding neuronal ensembles influence ...
In the well-known case of Henrietta Lacks, cells from her tumor were taken without consent and used more than 70 years ago to create the first immortal human cell line (“HeLa” cells). That event led to many scientific breakthroughs and to the debate ...
Patterns of spontaneous neuronal activity instruct the refinement of developing brain circuits
Human speech evolution is not just about having a speech-ready brain and vocal apparatus
HomeScienceVol. 385, No. 6710Support US OCTOPUS Act to keep octopuses wildBack To Vol. 385, No. 6710 Full accessLetter Share on Support US OCTOPUS Act to keep octopuses wildJennifer Jacquet [email protected], Becca Franks, [...] , Peter Godfrey-Smith, Walter Sanchez-Suarez, [...] , Peter Abrams, David Ainley, Juan Jose Alava Saltos, Kristin Andrews, Maya F. Bach, [...] , Carl T. Bergstrom, Jonath…
Plans to dismantle structures that support diversity, equity, and inclusion (DEI) are in motion across higher education in the United States. In March, Alabama passed Senate Bill 129, which prohibits educators from “compelling [students to] assent” to “divisive concepts” in higher education (1). This bill will negatively affect faculty and students, especially those from marginalized groups.
Metal oxide films are essential in most electronic devices, yet they are typically deposited at elevated temperatures by using slow, vacuum-based processes. We printed native oxide films over large areas at ambient conditions by moving a molten metal ...
Memory consolidation involves the synchronous reactivation of hippocampal cells active during recent experience in sleep sharp-wave ripples (SWRs). How this increase in firing rates and synchrony after learning is counterbalanced to preserve network ...
Air sensitivity remains a substantial barrier to the commercialization of sodium (Na)–layered oxides (NLOs). This problem has puzzled the community for decades because of the complexity of interactions between air components and their impact on both bulk ...
“Can machines think?” So asked Alan Turing in his 1950 paper, “Computing Machinery and Intelligence.” Turing quickly noted that, given the difficulty of defining thinking, the question is “too meaningless to deserve discussion.” As is often done in ...
At Fermilab, planned staff furlough, online screed highlight continuing management problems
Geoengineering study that would disperse alkaline chemicals off Cape Cod draws environmental opposition
Triple measurement of the Hubble constant using JWST suggests unidentified biases may account for disparate results
Lykos Therapeutics’s failure to win approval may trigger a strategic shift in psychedelic medicine
Science series to spotlight efforts to reduce parachute science, empower Global South countries
Antiviral therapies with reduced frequencies of administration and high barriers to resistance remain a major goal. For HIV, theories have proposed that viral-deletion variants, which conditionally replicate with a basic reproductive ratio [R0] > 1 (...
The chemical composition of the interstellar medium and planetary atmospheres is constantly in flux as atoms and molecules collide and interact with high-energy particles such as electrons, protons, and photons. These transformative processes ultimately ...
Hematopoietic stem cells (HSCs) are routinely mobilized from the bone marrow (BM) to the blood circulation for clinical transplantation. However, the precise mechanisms by which individual stem cells exit the marrow are not understood. This study ...
Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular processes, many biomolecular condensates exist in a solid-like state, and their function and regulation are less understood. We show that the tumor suppressor ...
Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for ...
One of the biggest neurophysiological science news headlines of the 2024 summer reported a critical link between post-traumatic stress disorder (PTSD), suicide, and brain injury from blast events in members of the elite US fighting force, Navy SEALS. ...
With vision and a big personality, Christian Happi has built a world-class genomics center so Africans can help Africa
Discussions around global equity and justice in science typically emphasize the lack of diversity in the editorial boards of scientific journals, inequities in authorship, “parachute research,” dominance of the English language, or scientific awards ...
A coherent section of drilled rocks provides a mineralogical glimpse of the oceanic mantle
Elite universities failed to grasp the pandemic needs of minority and lower-income students, finds a sociologist
HomeScienceVol. 385, No. 6709Accurately interpreting IPCC assessmentsBack To Vol. 385, No. 6709 Full accessLetter Share on Accurately interpreting IPCC assessmentsKornelis Blok [email protected], Mustafa Babiker, [...] , Christopher Bataille, Brett Cohen, [...] , Aleksandra Novikova, Sudarmanto Budi Nugroho, Daniela Anahi Toribio Ramirez, Stephanie Roe, and Masa Sugiyama+6 authors +4 authors fewe…
Blok et al. characterize our Policy Forum as an indictment of the Intergovernmental Panel on Climate Change’s (IPCC’s) estimates of mitigation costs, but that was not our intention. We agree with Blok et al.’s call to continually update the economics-focused integrated assessment models. This action, along with more cross-validation between bottom-up and top-down approaches, is precisely the goal of the piece.
In their Research Article “Illusory generalizability of clinical prediction models” (12 January, p. 164), A. M. Chekroud et al. demonstrate that making robust and generalizable predictions in clinical contexts is difficult. Their results reveal flaws in the current strategy of applying artificial intelligence to prediction tasks. The reuse of existing data from randomized controlled trials and the lack of iterative model development hinder the ability of machine learning models to contribute in clinical settings.
The upper mantle is critical for our understanding of terrestrial magmatism, crust formation, and element cycling between Earth’s solid interior, hydrosphere, atmosphere, and biosphere. Mantle composition and evolution have been primarily inferred by ...
Mammoth study in Chinese villages shows antibiotics that kill Helicobacter pylori reduced cancer risk
Underground churn from ancient continental breakups can explain highlands in Brazil, India, and South Africa
Workers in the Global South—from farm workers to scientists—power the world economy but face a yawning wage gap
Critics challenge explosive claim about Homo naledi, with implications for both human evolution and new models of scientific publishing
In ecosystems, sharks can be predators, competitors, facilitators, nutrient transporters, and food. However, overfishing and other threats have greatly reduced shark populations, altering their roles and effects on ecosystems. We review these changes and ...
The proliferating cell nuclear antigen (PCNA) clamp encircles DNA to hold DNA polymerases (Pols) to DNA for processivity. The Ctf18-RFC PCNA loader, a replication factor C (RFC) variant, is specific to the leading-strand Pol (Polε). We reveal here the ...
Late-onset Alzheimer’s disease (LOAD) is the most common form of Alzheimer’s disease (AD). However, modeling sporadic LOAD that endogenously captures hallmark neuronal pathologies such as amyloid-β (Aβ) deposition, tau tangles, and neuronal loss remains ...
Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays of molecularly defined neuron subsets and of immunocyte lineages remains unclear. We used a chemogenetic approach to ...
An enduring question in evolutionary biology concerns the degree to which episodes of convergent trait evolution depend on the same genetic programs, particularly over long timescales. In this work, we genetically dissected repeated origins and losses of ...
For cash-strapped researchers, fees are exacerbating long-standing inequalities in global science
HomeScienceVol. 385, No. 6708Voting for ecological protectionBack To Vol. 385, No. 6708 Full accessLetterOutside the Tower Share on Voting for ecological protectionMaya MayroseAuthors Info & AffiliationsScience1 Aug 2024Vol 385, Issue 6708p. 505DOI: 10.1126/science.adq6377 PREVIOUS ARTICLESafeguard stewards of biodiversity knowledgePreviousNEXT ARTICLESafeguard stewards of biodiversity knowledge—…
In their Research Article “The global distribution of plants used by humans” (19 January, p. 293), S. Pironon et al. provide the first global assessment of the distribution and conservation status of 35,687 plants used by people. However, the paper includes no information about the identity of the original holders of this vast biodiversity knowledge. Biodiversity studies must properly recognize Indigenous Peoples and local communities to avoid the misunderstanding and appropriation of Indigenous and local knowledge systems by Western science (1). Scientific practices should be adjusted to safeguard the rights of the diverse stewards of biodiversity knowledge.
Earlier this year, an international group of scientists published a paper in ScienceAdvances on the draft genome of the little bush moa (Anomalopteryx didiformis), one of about nine species of extinct flightless birds endemic to Aotearoa (New Zealand). ...
HomeScienceVol. 385, No. 6708Mexico must save the vaquita from gill netsBack To Vol. 385, No. 6708 Full accessLetter Share on Mexico must save the vaquita from gill netsLorenzo Rojas-Bracho [email protected], Barbara L. Taylor, [...] , Randall R. Reeves, Andrew Read, [...] , Jay Barlow, Greg Donovan, Peter O. Thomas, Frances Gulland, Sarah L. Mesnick, [...] , Robert L. Brownell Jr., Annette Henry…
Aortic baroreceptor afferents act as targets for blood pressure control in hypertension
Levis et al. raise concerns about the traceability of plant-use data and consequent lack of recognition of knowledge holders from Indigenous Peoples and local communities. We agree that Western science must enhance collaboration, representation, recognition, and support for Indigenous knowledge systems, but challenges associated with global plant-use data will need to be addressed to achieve these goals.
Patients with devastating illnesses demonstrate incredible courage in battling their disease. Innovative cell and gene therapies (CGTs), built on decades of research, are changing the lives of those who suffer from conditions ranging from cancer to ...
Plant prickles are controlled by genes involved in the final step of cytokinin biosynthesis
Integrated policy changes must be cross-sectoral, appropriate, strategic, and evidence-based
Following up tantalizing links between pathogens and brain disease, new projects search for causal evidence
Studies in climate chambers show humidity adds danger, but analyses of population-wide mortality rates suggest otherwise
Proof provides fresh tools to attack famed Riemann hypothesis, math’s biggest unsolved problem
Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors ...
Earthquakes vary in size over many orders of magnitude, often rupturing in complex multifault and multievent sequences. Despite the large number of observed earthquakes, the scaling of the earthquake energy budget remains enigmatic. We propose that ...
Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron’s eligibility to be recruited into the memory trace depends on its epigenetic state prior to encoding. Principal neurons in ...
HomeScienceVol. 385, No. 6707Clearing the AirBack To Vol. 385, No. 6707 Full accessIntroduction to Special Issue Share on Clearing the AirMichael A. Funk, Caroline Ash, [...] , Jesse Smith, Ekeoma Uzogara, and Brad Wible+2 authors fewerAuthors Info & AffiliationsScience25 Jul 2024Vol 385, Issue 6707pp. 378-379 NEXT ARTICLEHigh-resolution urban air pollution mappingNext ContentsInformation & Aut…
Six years ago, my colleagues and I published an article in the World Economic Forum asking if Africa was ready for the electric vehicle (EV) revolution. At that time, the African EV sector was nascent, and we concluded that more data and research were ...
The rapid global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the beginning of 2020 presented the world with its greatest health challenge in decades. It soon became clear that governments were unprepared to respond ...
Air pollution causes premature death and disease and disproportionately harms non-white and lower-income groups in the United States. Government policies are responsible for the racial disparity in air pollution exposure and related health outcomes. ...
The most up-to-date estimate of the global burden of disease indicates that ambient air pollution, including fine particulate matter and ozone, contributes to an estimated 5.2 million deaths each year. In this review, we highlight the challenges in ...
Variation in urban air pollution arises because of complex spatial, temporal, and chemical processes, which profoundly affect population exposure, human health, and environmental justice. This Review highlights insights from two popular in situ ...
Since 2011, a private company has sued to terminate protections for the Cristalino II State Park in Brazil’s state of Mato Grosso. The company is suspected of being a shell to enable private entities to gain rights to government land (1). On 23 April, after repeated appeals and counter-repeals, the Mato Grosso Court of Justice sided with the company and annulled the 2001 decree that created the park (2), despite evidence that the park’s creation was legal (3). The contested park area, spanning 118,000 ha, is a top conservation priority (4), especially for Amazonian tree species (5) and vulnerable faunal communities, such as the Endangered spider monkey Ateles marginatus (6). Moreover, the protected region plays a crucial role in inhibiting deforestation in the southern Amazon. Mato Grosso must appeal the decision.
HomeScienceVol. 385, No. 6707Disability and disaster: A deadly duoBack To Vol. 385, No. 6707 Full accessLetter Share on Disability and disaster: A deadly duoKathryn Romanchuk [email protected] and John-Ross RizzoAuthors Info & AffiliationsScience25 Jul 2024Vol 385, Issue 6707p. 376 PREVIOUS ARTICLEThe Heart and the Chip: Our Bright Future with RobotsPreviousNEXT ARTICLEBrazil’s court threatens Am…
HomeScienceVol. 385, No. 6707The Heart and the Chip: Our Bright Future with RobotsBack To Vol. 385, No. 6707 Full accessBooks et al.Podcast Share on The Heart and the Chip: Our Bright Future with RobotsScience25 Jul 2024Vol 385, Issue 6707p. 375 PREVIOUS ARTICLEThe first fossil collectorsPreviousNEXT ARTICLEDisability and disaster: A deadly duoNext ContentsBooksInformation & AuthorsMetrics & Ci…
Protective sports policies ostensibly based on biology inform broader ideas about ability and identity
The genomic landscape of a cell surface protein reveals how neuron identity is displayed
A neuron’s suitability to participate in a memory trace is modulated by its epigenetic state
Despite increasing evidence and awareness, many countries continue to have weak air quality regimes
There’s growing evidence that breathing polluted air increases the risk of osteoporosis
Communities living near mine wastes breathe air laden with potentially toxic dust. Health effects are now emerging
HomeScienceVol. 385, No. 6707News at a glanceBack To Vol. 385, No. 6707 Full accessIn Brief Share on News at a glanceScience25 Jul 2024Vol 385, Issue 6707pp. 348-349 PREVIOUS ARTICLENeutrality’s effects on academic freedomPreviousNEXT ARTICLEU.S. back in the race to forge unknown elementsNext ContentsPrime stegosaur skeleton sold for record sumFirst, the vultures died. Then, the humansExecs qui…
The idea that universities in the United States—and especially their presidents—should be politically neutral was taking hold long before their recent struggles in responding to the Israel–Hamas war. A document called the Kalven Report that was produced ...
Two atoms of element 116 demonstrate path to hunt for element 120 and extend the periodic table
As commercial fleets grow, concerns raised about ozone-destroying effects of metal particles
Brazilian Ministry of Health tells doctors to closely monitor pregnant women infected with the little-known Oropouche virus
Proximity labeling proteomics (PLP) strategies are powerful approaches to yield snapshots of protein neighborhoods. Here, we describe a multiscale PLP method with adjustable resolution that uses a commercially available photocatalyst, Eosin Y, which upon ...
The human mitochondrial genome encodes crucial oxidative phosphorylation system proteins, pivotal for aerobic energy transduction. They are translated from nine monocistronic and two bicistronic transcripts whose native structures remain unexplored, ...
Meiotic errors of relatively small chromosomes in oocytes result in egg aneuploidies that cause miscarriages and congenital diseases. Unlike somatic cells, which preferentially mis-segregate larger chromosomes, aged oocytes preferentially mis-segregate ...
One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations. Lack of inclusion must be addressed at-scale to identify causal disease factors and understand the genetic causes of health ...
Many species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus on how hosts affect their microbiomes. Hosts exert control over their ...
Nuclear engineer Greg Piefer hopes better neutron sources will help his company dominate the multibillon-dollar medical isotope market—and pay for fusion research
We describe an approach for designing high-affinity small molecule–binding proteins poised for downstream sensing. We use deep learning–generated pseudocycles with repeating structural units surrounding central binding pockets with widely varying shapes ...
Childhood malnutrition is a well-known problem in low- and middle-income countries, but children in countries such as Bangladesh also face increasing rates of obesity (1). Obesity in both public and private schools in Bangladesh ranges from 14 to 38% (2), and about 23.6% of adolescents are overweight (3). Because the food environment— i.e., the type and amount of food that is available and accessible—affects children’s dietary preferences and health outcomes, it is considered a primary cause of obesity (4, 5). Bangladesh must collect data about the food environment in and near schools and then use that information to address childhood obesity.
In the first 23 weeks of 2024, Brazil surpassed 6 million cases of dengue (1), a viral disease transmitted by Aedes aegypti mosquitoes (2). Dengue is a cyclical disease with seasonal variations, and outbreaks occur every year during the rainy periods (3, 4); however, the previous record infection rate was 1.7 million cases throughout all of 2015 (2). Despite ongoing mitigation efforts, Brazil faces challenges such as the resistance of the A. aegypti mosquito to insecticides (5), climate changes that favor the proliferation of the vector (3, 4), and a failure to eliminate breeding sites (6). Other countries in South America are facing similar infection rates and challenges (4, 7–9). This outbreak burdens Brazil’s public health system, and the resulting workplace absences have placed a substantial strain on the country’s industry and commerce (10, 11).
Any scientist knows that to be a good scientist, they must conduct thoughtful research; generate high-quality, verifiable results and analyses; and get them into circulation in the scientific community. However, what often goes underappreciated is that ...
Last month’s return to Earth of China’s lunar lander Chang’e-6 with samples from the far side of the Moon is a reminder that there are “firsts” in robotic space exploration still to be achieved. Unfortunately, this year has seen a major setback for the ...
Mostly inoperable since 2020, moored sensors are key to understanding global climate patterns
Alaska’s Bering Strait was hit by an unprecedented bloom of toxic organisms, which cause paralytic shellfish poisoning, in 2022
Direct observation is central to our understanding of adaptation, but evolution is rarely documented in a large, multicellular organism for more than a few generations. In this study, we observed evolution across a century-scale competition experiment, ...
TnpB nucleases represent the evolutionary precursors to CRISPR-Cas12 and are widespread in all domains of life. IS605-family TnpB homologs function as programmable RNA-guided homing endonucleases in bacteria, driving transposon maintenance through DNA ...
Although it is well known that the ancestors of modern humans and Neanderthals admixed, the effects of gene flow on the Neanderthal genome are not well understood. We develop methods to estimate the amount of human-introgressed sequences in Neanderthals ...
Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of ...
Ancient DNA study gives a Neanderthal-eye view of prehistory, offers clues to how our cousins vanished
Our Policy Forum argues that differences in structure and content mean that Indigenous knowledge must retain its integrity as a separate, parallel knowledge system. Analogous to philosophy, Indigenous knowledge should be taught alongside science as a separate form of knowledge, not within the science curriculum.
Chirality is a phenomenon with widespread relevance in fundamental physics, material science, chemistry, optics, and spectroscopy. In this work, we show that a free electron can be converted by the field cycles of laser light into a right-handed or left-...
Quantum computation and quantum communication are expected to provide users with capabilities inaccessible by classical physics. However, scalability to larger systems with many qubits is challenging. One solution is to develop a quantum network ...
One of the hallmarks of living organisms is their capacity for self-organization and regeneration, which requires a tight integration of metabolic and genetic networks. We sought to construct a linked metabolic and genetic network in vitro that shows ...
Black-phase formamidinium lead iodide (α-FAPbI3) perovskites are the desired phase for photovoltaic applications, but water can trigger formation of photoinactive impurity phases such as δ-FAPbI3. We show that the classic solvent system for perovskite ...
The relentless march of a highly pathogenic avian influenza virus (HPAIV) strain, known as H5N1, to become an unprecedented panzootic continues unchecked. The leap of H5N1 clade 2.3.4.4b from Eurasia and Africa to North America in 2021 and its further ...
Bioacoustics and artificial intelligence facilitate ecological studies of animal populations
A fungus uses different cell entry strategies, depending on its host’s hibernation status
HomeScienceVol. 385, No. 6705World science and Indigenous knowledgeBack To Vol. 385, No. 6705 Full accessLetter Share on World science and Indigenous knowledgeRex Ahdar, Brian Boyd, [...] , Ananish Chaudhuri, Kendall D. Clements [email protected], [...] , Garth Cooper, Douglas Elliffe, Brian Gill, Russell D. Gray, Natasha Hamilton-Hart, [...] , David Lillis, Michael Matthews, John Raine, Elizabet…
A. Black and J. M. Tylianakis (“Teach Indigenous knowledge alongside science,” Policy Forum, 9 February, p. 592) give an overly rosy picture of New Zealand’s policy of “mana ōrite,” or equal status for mātauranga Māori, in science education, which they say teaches Indigenous knowledge “alongside” science rather than “as” science. They suggest that this policy avoids problems such as teaching creationist myths in science class. However, the New Zealand Ministry of Education placed supernatural content directly into science and math curricula with no clarification that it was nonscientific material.
Supertoxic rodenticides can accumulate in birds, mammals, and insects, even killing some. Scientists want to understand the damage—and limit it
University of California, Irvine graduate student reported Bruce Blumberg after conference trip she called “absolute nightmare”
Scientists allege irregularities in high-profile papers documenting honey bee “odometer”
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven by ...
Understanding how numerous quantitative trait loci (QTL) shape phenotypic variation is an important question in genetics. To address this, we established a permanent population of 18,421 (18K) rice lines with reduced population structure. We generated ...
Transcribed enhancer maps can reveal nuclear interactions underpinning each cell type and connect specific cell types to diseases. Using a 5′ single-cell RNA sequencing approach, we defined transcription start sites of enhancer RNAs and other classes of ...
Academics researching online misinformation in the US are learning a hard lesson: Academic freedom cannot be taken for granted. They face a concerted effort—including by members of Congress—to undermine or silence their work documenting false and ...
A newly identified epigenetic modifier increases fetal hemoglobin in preclinical studies
We gave young scientists this prompt: Describe one change to scientific policy or culture that would substantially decrease incidents of scientific misconduct or other unethical behavior.
Large language models trained on sequence information alone can learn high-level principles of protein design. However, beyond sequence, the three-dimensional structures of proteins determine their specific function, activity, and evolvability. Here, we ...
Assembling titanium carbide (Ti3C2Tx) MXene nanosheets into macroscopic films presents challenges, including voids, low orientation degree, and weak interfacial interactions, which reduce mechanical performance. We demonstrate an ultrastrong macroscopic ...
Passive radiant cooling is a potentially sustainable thermal management strategy amid escalating global climate change. However, petrochemical-derived cooling materials often face efficiency challenges owing to the absorption of sunlight. We present an ...
ErythroMer, designed to be stored for years and work on any blood type, could provide a critical alternative when real blood is unavailable
ITER operations delayed to 2034, with energy-producing reactions expected 5 years later
Dearth of rigorous data means most rehabbers don’t know what happens to animals they’ve released back into the wild
Decision to abandon Chevron doctrine could have far-reaching implications for many government programs
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts prion disease progression. In this study, we describe ...
Inflammation and tissue damage associated with pancreatitis can precede or occur concurrently with pancreatic ductal adenocarcinoma (PDAC). We demonstrate that in PDAC coupled with pancreatitis (ptPDAC), antigen-presenting type I conventional dendritic ...
Measles virus (MeV) presents a public health threat that is escalating as vaccine coverage in the general population declines and as populations of immunocompromised individuals, who cannot be vaccinated, increase. There are no approved therapeutics for ...
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevated specifically in ILC2s and T helper 2 cells to drive ...
New approach leaves other creatures unharmed. “You cannot get anything better than this”
Transgender, travesti, and nonbinary (trans) individuals face considerable challenges in Brazil, which have been magnified by the COVID-19 pandemic (1). As trans scientists, we urge Brazil’s government to enact affirmative action policies to support trans individuals pursuing higher education as students and employees.
An intermediate virus–cell fusion step is revealed by an antibody with therapeutic potential
Senescence of postmitotic neurons presents challenges and opportunities to modify brain aging
In the face of rapid global changes, the agricultural sector in Latin America and the Caribbean (LAC) stands at a crossroads. The region, known for its rich biodiversity and considerable agricultural output, is increasingly challenged by climate change, ...
Crystalline materials with uniform molecular-sized pores are desirable for a broad range of applications, such as sensors, catalysis, and separations. However, it is challenging to tune the pore size of a single material continuously and to reversibly ...
Knowledge of Cambrian animal anatomy is limited by preservational processes that result in compaction, size bias, and incompleteness. We documented pristine three-dimensional (3D) anatomy of trilobites fossilized through rapid ash burial from a ...
Methylaluminoxane (MAO) is used as a precatalyst activator for million ton–scale production of commercial polyolefins, but its precise structure and associated activation mechanisms have been a fundamental research puzzle for more than 40 years. We ...
Despite their size, wetlands smaller than 8 ha perform valuable services, including biodiversity protection, floodwater storage, water quality maintenance, and climate regulation (1, 2). However, human activities and climate change have driven widespread loss and degradation of small wetlands, causing substantial declines in ecological functions (3). Although they may be more vulnerable and recover more slowly than large wetlands (4, 5), small wetlands have long been overlooked in conservation plans, perhaps as a result of inconsistent definitions and limited research attention (6). Recent policies have begun to prioritize small wetlands, but international cooperation will be required to implement the conservation efforts necessary to protect them.
Broader coverage can have economic, climate-related, animal welfare, and human health benefits
HomeScienceVol. 384, No. 6703Tokens: The Future of Money in the Age of the PlatformBack To Vol. 384, No. 6703 Full accessBooks et al.Podcast Share on Tokens: The Future of Money in the Age of the PlatformScience27 Jun 2024Vol 384, Issue 6703p. 1413 PREVIOUS ARTICLEGame theoriesPreviousNEXT ARTICLEProtect wetlands from legacy plasticsNext ContentsBooksInformation & AuthorsMetrics & CitationsView…
HomeScienceVol. 384, No. 6703Protect wetlands from legacy plasticsBack To Vol. 384, No. 6703 Full accessLetter Share on Protect wetlands from legacy plasticsXiaoli Zhao, Xiaowei Wu, [...] , Dandan Yu, Carolyn Lundquist, [...] , Chengjun Li [email protected], and Huan Zhong [email protected]+3 authors +1 authors fewerAuthors Info & AffiliationsScience27 Jun 2024Vol 384, Issue 6703pp. 1414-1415 PRE…
Critics slam vivarium as reckless, but scientists call it vital for preventing pandemics
Quick spread of “selfish” genetic sequences may one day knock back crop-destroying plants that have evolved to resist many herbicides
Cheaper, more varied probes will also warn of droughts, harmful algal blooms, and sea level rise
Recent findings on famed Ecuador ridge give hope that unique plants weren’t entirely lost
The molecular mechanisms that regulate breast cancer cell (BCC) metastasis and proliferation within the leptomeninges (LM) are poorly understood, which limits the development of effective therapies. In this work, we show that BCCs in mice can invade the ...
Persistent inflammation driven by cytokines such as type-one interferon (IFN-I) can cause immunosuppression. We show that administration of the Janus kinase 1 (JAK1) inhibitor itacitinib after anti–PD-1 (programmed cell death protein 1) immunotherapy ...
Unleashing antitumor T cell activity by checkpoint inhibitor immunotherapy is effective in cancer patients, but clinical responses are limited. Cytokine signaling through the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) ...
As the hunt for habitable Earth-like planets stalls, astronomers are turning to bigger worlds
HomeScienceVol. 384, No. 6702Ten must-read science historiesBack To Vol. 384, No. 6702 Full accessBooks et al.Review Roundup Share on Ten must-read science historiesTiago Saraiva [email protected], Emily Pawley [email protected], [...] , Anita Guerrini [email protected], Leah DeVun [email protected], [...] , Allison Margaret Bigelow [email protected], Tara Nummedal [email protected], Robyn d’Avig…
The world’s ecosystems, and the organisms that inhabit them, face unprecedented threats, including a changing climate and anthropogenic disturbances. Understanding the baseline habitat requirements of living organisms is essential to developing effective conservation strategies (1). Nonetheless, studies often fail to consider the biological sex of organisms, an oversight that could substantially impede conservation efforts (2).
Despite declines in transportation emissions, urban North America and Europe still face unhealthy air pollution levels. This has challenged conventional understanding of the sources of their volatile organic compound (VOC) precursors. Using airborne flux ...
Extreme weather events radically alter ecosystems. When ecological damage persists, selective pressures on individuals can change, leading to phenotypic adjustments. For group-living animals, social relationships may be a mechanism enabling adaptation to ...
Vegetation and soils are taking up approximately 30% of anthropogenic carbon dioxide emissions because of small imbalances in large gross carbon exchanges from productivity and turnover that are poorly constrained. We combined a new budget of radiocarbon ...
The field-effect transistor (FET) is a cornerstone of modern electronics, pivotal in the development of compact and efficient integrated microprocessors and memory storage devices capable of low-power operation. At the heart of a FET is a semiconductor ...
Long associated with aging, senescent cells can promote health and have physiological roles
In 2024, China issued its most recent government work report, which includes a requirement for enhanced control of plastic pollution in water and soil (1). However, the policy does not address contamination caused by the plastic foam used in fishing gear.
Dark clouds loom on the nuclear horizon, with threats from all directions: Russia’s nuclear bombast in its war on Ukraine, China’s construction of hundreds of nuclear missile silos, North Korea’s missile testing, India and Pakistan’s ongoing nuclear ...
HomeScienceVol. 384, No. 6702Sustainable development in global border regionsBack To Vol. 384, No. 6702 Full accessLetter Share on Sustainable development in global border regionsYi Cheng, Zhenci Xu, and Haimeng Liu [email protected]Authors Info & AffiliationsScience20 Jun 2024Vol 384, Issue 6702p. 1309 PREVIOUS ARTICLETen must-read science historiesPreviousNEXT ARTICLESex-based differences affec…
High dynamic strength is of fundamental importance for fibrous materials that are used in high–strain rate environments. Carbon nanotube fibers are one of the most promising candidates. Using a strategy to optimize hierarchical structures, we fabricated ...
Discovery of new seismic concern stokes flooding fear for the densely populated delta region
Republican leaders of two committees want to streamline agency’s 27 components, tighten policies
Bacteria can repurpose their own bacteriophage viruses (phage) to kill competing bacteria. Phage-derived elements are frequently strain specific in their killing activity, although there is limited evidence that this specificity drives bacterial ...
Polycystic ovary syndrome (PCOS), a prevalent reproductive disorder in women of reproductive age, features androgen excess, ovulatory dysfunction, and polycystic ovaries. Despite its high prevalence, specific pharmacologic intervention for PCOS is ...
Mitochondria are critical for proper organ function and mechanisms to promote mitochondrial health during regeneration would benefit tissue homeostasis. We report that during liver regeneration, proliferation is suppressed in electron transport chain (...
Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of individual cells and their connectivity in the human organ–...
The world is facing an interconnected crisis caused by a variety of factors including climate change, water scarcity, biodiversity loss, and chemical waste. One of most prominent factors is the exploitation of limited resources to convert them into ...
HomeScienceVol. 384, No. 6701A neuroscientist’s duty to Black ancestorsBack To Vol. 384, No. 6701 Full accessLetterPast as Prologue Share on A neuroscientist’s duty to Black ancestorsChandler Wright [email protected]Authors Info & AffiliationsScience13 Jun 2024Vol 384, Issue 6701p. 1183 PREVIOUS ARTICLEThreats posed by water transfer in IranPreviousNEXT ARTICLEIn Science JournalsNext ContentsIn…
Iran is experiencing unparalleled challenges related to water scarcity (1), including the desiccation of lakes and rivers, a decrease in groundwater levels, land subsidence, the degradation of waterquality, desertification, soil erosion, and dust storms (2). In response, the Iranian government has begun transferring lake water and desalinated seawater to regions plagued by desertification and scant rainfall to provide drinking water and meet agricultural and industrial water demands (3–6). Many water transfer projects are underway, and more are planned, but few have undergone a thorough evaluation of their environmental, economic, and social implications (4). Iran should consider the environmental effects of transferring water and focus on other solutions to water scarcity.
HomeScienceVol. 384, No. 6701Rare earth element mining threatens Malaysia’s biodiversityBack To Vol. 384, No. 6701 Full accessLetter Share on Rare earth element mining threatens Malaysia’s biodiversityXiangbo Yin [email protected], Lee Ping Ang, and Zi Yuan ChangAuthors Info & AffiliationsScience13 Jun 2024Vol 384, Issue 6701p. 1182 PREVIOUS ARTICLERethinking quantum orthodoxyPreviousNEXT ARTICLE…
Intravenous targeting of airway basal cells for cystic fibrosis gene therapy overcomes lung barriers
Antimalarial suppresses ovarian androgen synthesis to relieve polycystic ovary syndrome
Since 2001, the United Nations has designated 20 June as World Refugee Day. It seeks to raise awareness of refugees—currently estimated to be more than 114 million persons internally displaced, exiled, or on the move—and the often-harsh conditions they ...
Radiative cooling textiles hold promise for achieving personal thermal comfort under increasing global temperature. However, urban areas have heat island effects that largely diminish the effectiveness of cooling textiles as wearable fabrics because they ...
In vivo genome correction holds promise for generating durable disease cures; yet, effective stem cell editing remains challenging. In this work, we demonstrate that optimized lung-targeting lipid nanoparticles (LNPs) enable high levels of genome editing ...
Find links practice to “Hero Twins” myth and shows youngsters were related to today’s Indigenous Maya
After 2022 exoneration, fresh inquiry concludes Steven Newmaster fabricated data that questioned quality of echinacea, ginkgo, and other substances
Negative vote on MDMA for PTSD may hold lessons for other mental health treatments in development
Pivotal trial of Eli Lilly’s donanemab leaves questions about how to prescribe it and minimize side effects
How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we established a systemwide portrait of KRAS- and extracellular signal–regulated kinase (ERK)–dependent gene transcription in KRAS-mutant cancer to delineate the molecular ...
Fundamental limits of cellular deformations, such as hyperextension of a living cell, remain poorly understood. Here, we describe how the single-celled protist Lacrymaria olor, a 40-micrometer cell, is capable of reversibly and repeatably extending its ...
In addition to their intrinsic rewarding properties, opioids can also evoke aversive reactions that protect against misuse. Cellular mechanisms that govern the interplay between opioid reward and aversion are poorly understood. We used whole-brain ...
To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent phosphoproteome in KRAS-mutant pancreatic cancer. We determined that ERK1 and ERK2 share ...
After antigen stimulation, naïve T cells display reproducible population-level responses, which arise from individual T cells pursuing specific differentiation trajectories. However, cell-intrinsic predeterminants controlling these single-cell decisions ...
Four decades after his lab found odd, massive particles inside cells, Leonard Rome is still determined to figure out what “vaults” do
Successive cleavages of amyloid precursor protein C-terminal fragment with 99 residues (APP-C99) by γ-secretase result in amyloid-β (Aβ) peptides of varying lengths. Most cleavages have a step size of three residues. To elucidate the underlying mechanism,...
Spontaneous mirror symmetry breaking by formation of chiral structures from achiral building blocks and emergent polar order are phenomena rarely observed in fluids. Separately, they have both been found in certain nematic liquid crystalline phases; ...
As temperatures and evidence of climate impacts mount, so too do pressures to enhance climate policy ambition and implementation. In a previous piece, I have argued that to respond to these pressures requires rebalancing focus from target setting to ...
Very-low-mass stars (those less than 0.3 solar masses) host orbiting terrestrial planets more frequently than other types of stars. The compositions of those planets are largely unknown but are expected to relate to the protoplanetary disk in which they ...
Despite great progress in biomedical research, the health of the US population appears to be getting worse. The United States spends substantially more per capita on health care than other wealthy countries, yet US life expectancy ranks low among its ...
Recent promotion of new reactor technologies appears to disregard decades-old concerns about nuclear proliferation
A futurist probes the potential of engineered organisms and biologically inspired devices
HomeScienceVol. 384, No. 6700Team scientists should normalize disagreementBack To Vol. 384, No. 6700 Full accessLetter Share on Team scientists should normalize disagreementNicholas A. Coles [email protected], Elizabeth R. Tenney, [...] , Jason M. Chin, Jack C. Friedrich, [...] , Rose E. O’Dea, and Alex O. Holcombe+3 authors +1 authors fewerAuthors Info & AffiliationsScience6 Jun 2024Vol 384, Iss…
On 16 April, Brazil’s National Council for Scientific and Technological Development (CNPq) launched the Brazilian Talent Repatriation Program (BTRP) (1), a 5-year, US$194 million initiative aimed at attracting Brazilian researchers based abroad back to Brazilian universities, research centers, and private sector research. The package includes well-paid scholarships, research aid, and health and retirement contributions (1, 2). However, the BTRP plan will likely exacerbate the present high unemployment rates (3, 4) among Brazil’s scientists.
Achievement demonstrates feasibility of making all of life’s code easily searchable, researchers say
Deforestation and climate change may help midges spread Oropouche virus far beyond the Amazon Basin
Senior author acknowledges manipulated figures in study tying a form of amyloid protein to memory impairment
Republicans attacked former NIAID director on multiple fronts but Democrats solidly stood behind retired scientist
World Health Assembly gives negotiators another year after talks stall over sharing of pathogens, vaccines
Generated by plagiarism disguisers, these red flags can point to deeper problems with a paper
Abnormal calcium signaling is a central pathological component of Alzheimer’s disease (AD). Here, we describe the identification of a class of compounds called ReS19-T, which are able to restore calcium homeostasis in cell-based models of tau pathology. ...
Tumors with the same diagnosis can have different molecular profiles and response to treatment. It remains unclear when and why these differences arise. Somatic genomic aberrations occur within the context of a highly variable germline genome. ...
Stem cells play a critical role in cancer development by contributing to cell heterogeneity, lineage plasticity, and drug resistance. We created gene expression networks from hundreds of mouse tissue samples (both normal and tumor) and integrated these ...
Low uptake of the COVID-19 vaccine in the US has been widely attributed to social media misinformation. To evaluate this claim, we introduce a framework combining lab experiments (total N = 18,725), crowdsourcing, and machine learning to estimate the ...
During Heinrich events, great armadas of icebergs episodically flooded the North Atlantic Ocean and weakened overturning circulation. The ice discharges of these episodes constrain the sensitivity of overturning circulation to iceberg melting. We ...
Last week, Science, Science Advances, and Science Translational Medicine published an extensive set of papers from the PsychENCODE Consortium, a multi-institutional collaboration whose aim is to study the genetics of neuropsychiatric disorders such as ...
A social-moral norm against new fossil fuel projects has strong potential to contribute to achieving global climate goals
Human skin sensing of mechanical stimuli originates from transduction of mechanoreceptors that converts external forces into electrical signals. Although imitating the spatial distribution of those mechanoreceptors can enable developments of electronic ...
Time crystals (TCs) are many-body systems that display spontaneous breaking of time translation symmetry. We demonstrate a TC by using driven-dissipative condensates of microcavity exciton-polaritons, spontaneously formed from an incoherent particle ...
HomeScienceVol. 384, No. 6699Eve: The Disobedient Future of BirthBack To Vol. 384, No. 6699 Full accessBooks et al.Podcast Share on Eve: The Disobedient Future of BirthScience30 May 2024Vol 384, Issue 6699p. 965 PREVIOUS ARTICLEHearing the seasPreviousNEXT ARTICLESafely manage Alabama’s Mobile-Tensaw DeltaNext ContentsBooksInformation & AuthorsMetrics & CitationsView OptionsReferencesMediaTable…
Coupling skin bacteria and electronics opens paths to adaptive treatment of inflammation
Governments may have the capacity to flood social media with fake news, but little is known about the use of flooding by ordinary voters. In this work, we identify 2107 registered US voters who account for 80% of the fake news shared on Twitter during ...
Pakistan remains one of the last polio-endemic countries (1). The Pakistani government, along with its global partners, has successfully expanded vaccine coverage in conflict-affected and high-risk regions (2). However, militant attacks on polio vaccination teams, particularly by the Tehrik-e Taliban Pakistan, have reached unprecedented levels in the past 2 years (3–5). Pakistan and the global community must ensure the safety of vaccination workers.
Large-scale road construction in China’s mountainous regions has led to many exposed road slopes. Bare road slope patches, stripped of soil and vegetation, have resulted in severe landscape fragmentation and destructive effects on surrounding habitats (1, 2). They are also potentially dangerous to humans. In April, the slope of a section of the Yinkun Expressway roadbed collapsed, blocking the road with about 4000 m3 of debris (3). China needs long-term strategies to stabilize and restore road slopes.
HomeScienceVol. 384, No. 6699Safely manage Alabama’s Mobile-Tensaw DeltaBack To Vol. 384, No. 6699 Full accessLetter Share on Safely manage Alabama’s Mobile-Tensaw DeltaGabriel de Oliveira [email protected], John Lehrter, [...] , Sean Powers, Guilherme Mataveli, and Celso Santos+2 authors fewerAuthors Info & AffiliationsScience30 May 2024Vol 384, Issue 6699p. 966 PREVIOUS ARTICLEEve: The Disobedi…
Five drugs are now approved or in trials for genetic condition that triggers misplaced bone growth
Microorganism that kills victims within days leaps from Caribbean to the Red Sea, alarming marine scientists
A mouse study challenges popular “glymphatic” theory, but its methodology is drawing criticism
Before its computer crashed, venerable NASA probe may have entered mysterious new region beyond the Solar System
RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during human brain development has not been systematically investigated. In ...
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multiomics ...
Genomic profiling in postmortem brain from autistic individuals has consistently revealed convergent molecular changes. What drives these changes and how they relate to genetic susceptibility in this complex condition are not well understood. We ...
The molecular pathology of stress-related disorders remains elusive. Our brain multiregion, multiomic study of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) included the central nucleus of the amygdala, hippocampal dentate ...
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation and the development of more effective therapies. Here, we performed single-cell dissection of schizophrenia-associated transcriptomic changes in the human prefrontal ...
The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally defined spatial ...
Nucleotide variants in cell type–specific gene regulatory elements in the human brain are risk factors for human disease. We measured chromatin accessibility in 1932 aliquots of sorted neurons and non-neurons from 616 human postmortem brains and ...
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis-...
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain. However, prioritizing risk genes and mechanisms is ...
“AI-Powered Forecasting” was recently on the cover of Science, highlighting a new deep learning model for much faster and more accurate weather forecasting. Known as GraphCast, it outperformed the gold-standard system and had an accuracy of 99.7% for ...
The United Kingdom may soon become a world leader in forging a smoke-free generation. Last month, the country passed a bill that bans the sale of cigarettes to anyone born in 2009 or later. The prime minister claims the policy will “phase out smoking in ...
An inhibitor of a nonhormonal target is identified using a DNA-encoded chemical library
Reservoirs of neutral hydrogen may block ionizing radiation from escaping distant galaxies
HomeScienceVol. 384, No. 6698Hope for limestone langurs’ conservationBack To Vol. 384, No. 6698 Full accessLetter Share on Hope for limestone langurs’ conservationPenglai Fan, Michael J. Lawes, [...] , Ruoshuang Liu, and Qihai Zhou [email protected]+1 authors fewerAuthors Info & AffiliationsScience23 May 2024Vol 384, Issue 6698p. 855 PREVIOUS ARTICLEThe cesarean section, in contextPreviousNEXT AR…
Apparent overabundance means theories of how galaxies took shape in the early universe may need adjusting
Market uncertainties, safety rules, and export concerns stand in way of H5N1 shots for cattle
Leading scientist at Leiden University and her husband created a 30-year “culture of fear” and violated academic integrity, investigation panel says
Preparation requires technical research and development, as well as adaptive, proactive governance
Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region ...
Contemporary materials discovery requires intricate sequences of synthesis, formulation, and characterization that often span multiple locations with specialized expertise or instrumentation. To accelerate these workflows, we present a cloud-based ...
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs) is inefficient and may be ...
Using tools increases foraging success in sea otters and protects their teeth from damage
Four new studies inform on the multistep path to generate broadly active HIV-1 antibodies
Comprehensive spatial planning in international waters is key to achieving ocean sustainability
Autoimmune conditions underlie some cases of psychosis. Scientists are expanding their search for patients, who often benefit from treatment
Automated labs spread across the globe create, test, and assemble materials—no humans required
The decreasing cost of electricity worldwide from wind and solar energy, as well as that of end-use technologies such as electric vehicles, reflect substantial progress made toward replacing fossil fuels with alternative energy sources. But a full ...
In 2023, the National Institutes of Health (NIH) implemented a new Data Management and Sharing (DMS) Policy, which aims to maximize the amount of scientific data shared (1). For all research conducted at or funded by NIH, the policy requires a DMS Plan that describes how data will be managed and shared over the life of a project, including key information such as repositories where the data will be deposited. To increase the policy’s impact, NIH should empower stakeholders by expanding the resources provided to prepare, review, and implement DMS Plans.
HomeScienceVol. 384, No. 6697Undergraduate research data crucial to equityBack To Vol. 384, No. 6697 Full accessLetter Share on Undergraduate research data crucial to equityDustin B. Thoman [email protected], Jessi L. Smith, [...] , Ivan A. Hernandez, Christal D. Sohl, and Miguel T. Villodas+2 authors fewerAuthors Info & AffiliationsScience16 May 2024Vol 384, Issue 6697p. 747 PREVIOUS ARTICLEThe …
Sophisticated statistical mechanics approaches and human intuition have demonstrated the possibility of self-assembling complex lattices or finite-size constructs. However, attempts so far have mostly only been successful in silico and often fail in ...
The efficiency and longevity of metal-halide perovskite solar cells are typically dictated by nonradiative defect-mediated charge recombination. In this work, we demonstrate a vapor-based amino-silane passivation that reduces photovoltage deficits to ...
Reproduction includes two energy investments—the energy in the offspring and the energy expended to make them. The former is well understood, whereas the latter is unquantified but often assumed to be small. Without understanding both investments, the ...
Electronic band convergence can have a beneficial impact on thermoelectric performance, but finding the right band-converged compositions is still time-consuming. We propose a method for designing a series of compositions with simultaneous band ...
Knowledge resources and financial capital are mainly concentrated in the Global North (1), whereas the Global South, particularly Africa, lacks both investment in research (2, 3) and researchers (4). As a result, less than 1% of the global research output is produced by African institutions (5). Moreover, the majority of scientific articles reporting research conducted in Africa include foreign coauthors (6, 7), and African researchers rarely attain prestigious first or last authorship positions (8). Intra-African cooperation is also rare (5). Although research investment is a systemic problem that will require changes by the governments and institutions in African countries, individual African researchers can still take steps to improve the quality and quantity of research conducted in Africa by Africans.
Night bikers deliver meds and cholera sleuths persist as gangs dominate life and landscape
Universities could no longer store Medicare and Medicaid data, and costs for many researchers would rise
To fully understand how the human brain works, knowledge of its structure at high resolution is needed. Presented here is a computationally intensive reconstruction of the ultrastructure of a cubic millimeter of human temporal cortex that was surgically ...
Phonons play a crucial role in many properties of solid-state systems, and it is expected that topological phonons may lead to rich and unconventional physics. On the basis of the existing phonon materials databases, we have compiled a catalog of ...
The Hubbard model is an iconic model in quantum many-body physics and has been intensely studied, especially since the discovery of high-temperature cuprate superconductors. Combining the complementary capabilities of two computational methods, we found ...
Despite a half-century of advancements, global magnetic resonance imaging (MRI) accessibility remains limited and uneven, hindering its full potential in health care. Initially, MRI development focused on low fields around 0.05 Tesla, but progress halted ...
HomeScienceVol. 384, No. 6696Can the market in voluntary carbon credits help reduce global emissions in line with Paris Agreement targets?Back To Vol. 384, No. 6696 Full accessExpert Voices Share on Can the market in voluntary carbon credits help reduce global emissions in line with Paris Agreement targets?Rohini Pande https://orcid.org/0000-0002-0090-0987Authors Info & AffiliationsScience9 May 2…
Troubling eugenicist ideas appeared alongside calls for liberty and equality in the works of Enlightenment thinkers
Dust profoundly influences interactions between Earth and the atmosphere, particularly in arid regions (1). Dust storms, which are prevalent in dry, vegetation-free areas, can bury settlements, destroy agriculture, obstruct water infrastructure, cause visibility issues on roads, and substantially affect the environment (2). The Hur al-Azim Marshes, situated along the border of Iran and Iraq, have faced water shortages and pollution, which have increased the threat of dust storms. Iran and neighboring countries should work to restore the marshes to prevent damage caused by dust.
HomeScienceVol. 384, No. 6696Combating sediment surge in Tibetan riversBack To Vol. 384, No. 6696 Full accessLetter Share on Combating sediment surge in Tibetan riversHong Yang [email protected], Defu Liu, [...] , Julian R. Thompson, and Roger J. Flower+1 authors fewerAuthors Info & AffiliationsScience9 May 2024Vol 384, Issue 6696p. 630 PREVIOUS ARTICLEStates of mindPreviousNEXT ARTICLERestore Ir…
HomeScienceVol. 384, No. 6696A space camp’s cultural exchangeBack To Vol. 384, No. 6696 Full accessLetterOutside the Tower Share on A space camp’s cultural exchangeAgata Kołodziejczyk and Carolina Orozco Donneys [email protected]Authors Info & AffiliationsScience9 May 2024Vol 384, Issue 6696p. 631 PREVIOUS ARTICLERestore Iran’s marshes to prevent dust stormsPreviousNEXT ARTICLEIn Science Journals…
Nasal chemosensation is considered the evolutionarily oldest mammalian sense and, together with somatosensation, is crucial for neonatal well-being before auditory and visual pathways start engaging the brain. Using anatomical and functional approaches ...
On 2 April, I received an email that changed the course of the next 2 weeks. The Select Subcommittee on the Coronavirus Pandemic, chaired by United States Congressman Brad Wenstrup, invited me to testify along with my counterparts at Nature and The ...
New analyses show that trait variability links evolution across vastly different timescales
Low-field magnetic resonance imaging can be engineered for widespread point-of-care diagnostics
An artificial tactile system mimicking human touch enables effective object recognition
Despite identifying El Niño events as a factor in dengue dynamics, predicting the oscillation of global dengue epidemics remains challenging. Here, we investigate climate indicators and worldwide dengue incidence from 1990 to 2019 using climate-driven ...
The quantum anomalous Hall effect (QAHE) is a robust topological phenomenon that features quantized Hall resistance at zero magnetic field. We report the QAHE in a rhombohedral pentalayer graphene-monolayer tungsten disulfide (WS2) heterostructure. ...
Healthy volunteers—who usually join studies for money—deserve special attention, researchers say
Well-intentioned decision to switch oral polio vaccines in 2016 backfired, new draft report says
New policies for gain-of-function and “dual-use” research will cover broader swath of experiments
In AU$940 million deal, PsiQuantum will build “utility scale” facility to harness photons
Foreign trainees seeking U.S. medical residencies pay hefty sums to build research resumes
The developmental decision made by malaria parasites to become sexual underlies all malaria transmission. Here, we describe a rich atlas of short- and long-read single-cell transcriptomes of over 37,000 Plasmodium falciparum cells across ...
Cell cycle events are coordinated by cyclin-dependent kinases (CDKs) to ensure robust cell division. CDK4/6 and CDK2 regulate the growth 1 (G1) to synthesis (S) phase transition of the cell cycle by responding to mitogen signaling, promoting E2F ...
Certain people occupy topological positions within social networks that enhance their effectiveness at inducing spillovers. We mapped face-to-face networks among 24,702 people in 176 isolated villages in Honduras and randomly assigned villages to ...
B lymphocytes are essential mediators of humoral immunity and play multiple roles in human cancer. To decode the functions of tumor-infiltrating B cells, we generated a B cell blueprint encompassing single-cell transcriptome, B cell–receptor repertoire, ...
Claudia Sheinbaum Pardo would be first researcher to lead the country, but critics worry she’ll be as hostile to science as her predecessor
HomeScienceVol. 384, No. 6695A fellow engineer and presidential rivalBack To Vol. 384, No. 6695 Full accessFeature Share on A fellow engineer and presidential rivalRodrigo Pérez OrtegaAuthors Info & AffiliationsScience2 May 2024Vol 384, Issue 6695p. 504DOI: 10.1126/science.adq1748 PREVIOUS ARTICLEA scientist for presidentPreviousNEXT ARTICLEConductive hydrogels put electrons in chargeNext Conte…
A well-researched account of the factors that drive pandemics misses an opportunity to indict broader social systems
HomeScienceVol. 384, No. 6695Groundwater flooding risks overlookedBack To Vol. 384, No. 6695 Full accessLetter Share on Groundwater flooding risks overlookedHamid M. Behzad and Yunpeng Nie [email protected]Authors Info & AffiliationsScience2 May 2024Vol 384, Issue 6695pp. 518-519DOI: 10.1126/science.ado6820 PREVIOUS ARTICLEPandemics and their accelerantsPreviousNEXT ARTICLENextgen Voices: Prevent…
Add your voice to Science! Our new NextGen Voices survey is now open: What one change to scientifi c policy or culture would substantially decrease incidents of scientifi c misconduct or other unethical behavior?
Pakistan is home to two otter species, the Eurasian otter (Lutra lutra) and the smooth-coated otter (Lutrogale perspicillata). Two decades ago, these species thrived in habitats across Pakistan, but now they are limited to isolated patches in their range (1), are classified as Near Threatened in Pakistan (2), and are listed in Appendix II of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) (3). Pakistan must take steps to protect otters.
Global biodiversity decline is a pressing environmental challenge in the 21st century (1), and both international platforms, such as the United Nations Conference of the Parties (2), and regional development plans [e.g., (3)] focus on biodiversity conservation. However, because of the public appeal of charismatic species, research resources are predominantly invested in birds and mammals (4) and often exclude noncharismatic species, such as fish, insects, and plants. Contrary to perceptions, the ecological and economic consequences of noncharismatic species are often substantial. Researchers must study noncharismatic species to inform balanced biodiversity goals (5).
Marine stratocumulus clouds are the “global reflectors,” sharply contrasting with the underlying dark ocean surface and exerting a net cooling on Earth’s climate. The magnitude of this cooling remains uncertain in part owing to the averaged ...
Thomas Südhof says mistakes in co-authored publications are honest errors that don’t affect studies' conclusions
Hardy zircon minerals found in Australian rocks suggest conditions for life existed 4 billion years ago
At the end of May, 194 member states of the World Health Organization (WHO) will meet for the World Health Assembly. Negotiations underway now will determine whether they vote then to adopt a pandemic agreement. For the past 2 years, discussions have ...
Next round of international climate simulations will seek to curb excess energy use for computation
Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has advanced ...
Tubulin, one of the most abundant cytoskeletal building blocks, has numerous isotypes in metazoans encoded by different conserved genes. Whether these distinct isotypes form cell type– and context-specific microtubule structures is poorly understood. ...
Transcription initiation is a process that is essential to ensuring the proper function of any gene, yet we still lack a unified understanding of sequence patterns and rules that explain most transcription start sites in the human genome. By predicting ...
Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to very broad (generalists). Two general paradigms have been proposed to explain this variation: (i) trade-offs between performance efficiency and breadth ...
That behavioral change could explain the remarkable diversity of cichlid fish in Africa’s Lake Tanganyika
The health risks of social isolation and loneliness are inspiring government action and a hunt for effective interventions
Quantitative analysis of biodistribution and clearance may improve nanoparticle development
HomeScienceVol. 384, No. 6694Dangers of disposable electronic devicesBack To Vol. 384, No. 6694 Full accessLetter Share on Dangers of disposable electronic devicesLaura Young [email protected], Sue Dawson, [...] , David Lavallee, Mark Midownik, [...] , Imogen Napper, Richard Thompson, and Rebecca Wade+4 authors +2 authors fewerAuthors Info & AffiliationsScience25 Apr 2024Vol 384, Issue 6694p. 393…
HomeScienceVol. 384, No. 6694A future to look forward toBack To Vol. 384, No. 6694 Full accessBooks et al.Podcast Share on A future to look forward toScience25 Apr 2024Vol 384, Issue 6694p. 392DOI: 10.1126/science.adp6426 PREVIOUS ARTICLEData, death, and what comes nextPreviousNEXT ARTICLEDangers of disposable electronic devicesNext ContentsInformation & AuthorsMetrics & CitationsView OptionsRe…
All brains work differently. Individuals process information and engage with the world in ways that are influenced by a multitude of biological, cultural, and social factors. In the world of science, these differences are what spark innovation. This is ...
N-Heteroaromatics are key elements of pharmaceuticals, agrochemicals, and materials. N-Heteroarynes provide a scaffold to build these essential molecules but are underused because five-membered N-heteroarynes have been largely inaccessible on account of ...
Degeneracies in multilayer graphene, including spin, valley, and layer degrees of freedom, can be lifted by Coulomb interactions, resulting in rich broken-symmetry states. Here, we report a ferromagnetic state in charge-neutral ABCA-tetralayer graphene ...
The needs of marginalized groups must be central to sustainability goals, argues a sociologist
Seagrass meadows—marine ecosystems that support biodiversity and provide a range of other ecosystem services—are globally in decline (1). Many species use seagrass meadows as foraging grounds, spawning grounds, and shelter, including migratory species such as brant geese, the dugong, and the green turtle (2, 3). Conserving these valuable ecosystems will require comprehensive global maps of their locations (4) and a better understanding of the species that depend on them (3).
During the 28th annual meeting of the Conference of Parties to the UN Framework Convention on Climate Change (COP28) held in November and December 2023, the UN Food and Agriculture Organization (FAO) released a roadmap for transforming food systems. The plan aims to end world hunger without breaching the relatively safe 1.5°C global temperature rise threshold (1). The livestock industry is food systems’ biggest climate culprit, accounting for more than half of food systems emissions (2) and at least 16.5% of all anthropogenic greenhouse gas (GHG) emissions (2, 3). FAO’s roadmap calls for intensification of livestock production—i.e., keeping more livestock in less space—to cut GHG emissions. However, this recommendation conflicts with the findings in past FAO reports (4, 5) and will not solve the problem of livestock emissions.
As a seven-year-old child, I experienced war in Cyprus. Armed conflict has not been far from my conscience ever since. At a time when there are active conflicts in many parts of the world, war is unlikely to be far from many children’s minds globally ...
Climate snapshots suggest carbon dioxide levels were surprisingly modest during ancient warm period
Veterinarians and researchers on the front lines say it has taken too long to share data on viral changes, spread, and milk safety
Some worry the findings will stall efforts to halt logging—the root cause of declining caribou populations
Endoplasmic reticulum stress–independent phosphorylation of IRE1α is a convergence point of multiple KRAS inhibitor resistance mechanisms.
There are no cures for the most common neurodegenerative diseases. None of the currently approved treatments cure or halt these conditions; rather, they address symptoms or slow disease progression. A focus on protein deposits in the brain—a hallmark of ...
Fibrosis-associated loss of Kupffer cells is compensated by bacteria-filtering monocyte syncytia in the liver.
Defaulting to “no cutlery” and rewarding consumers with “green points” promoted behaviors that reduced plastic waste.
Apparent ligand oxidation enables catalysis by copper in a more stable oxidation state.
The candidate who received the most votes in the 13 August Argentinean presidential primary election, Javier Milei, represents the extreme right-wing liberal party, “La Libertad Avanza” (Liberty Advances) (1). After winning the election, Milei promised to eliminate the Ministry of Science and the Argentine Research Council (CONICET) and argued that scientists should find work in the private sector instead (2).
Analysis of plant and animal communities spanning from 1960 to 2020 and across six taxon groups reveals prevailing decreases in body size.
Apparent ligand oxidation enables catalysis by copper in a more stable oxidation state.
The social benefit of technologies is frequently unevenly realized across the United States. Rural communities, individuals with disabilities, and historically marginalized groups face out-of-reach costs or lack access to products that meet their needs. ...
An implantable bioelectronic device detects the early signs of kidney transplant rejection in rats
Gastric innate immune cells coordinate digestion and metabolic responses to an abundant insoluble dietary polysaccharide.
Harmful tropes can lead to misguided assumptions when designing devices for people with disabilities
HomeScienceVol. 381, No. 6662Heatwaves hasten polymer degradation and failureBack To Vol. 381, No. 6662 Full accessLetter Share on Heatwaves hasten polymer degradation and failureXin-Feng Wei and Mikael S. Hedenqvist [email protected]Authors Info & AffiliationsScience7 Sep 2023Vol 381, Issue 6662p. 1058 PREVIOUS ARTICLEEditorial Expression of ConcernPreviousNEXT ARTICLEProtest anti-science agenda…
A fast, sediment-laden current reworked the seafloor and broke telecommunication cables during the 2022 Hunga Tonga eruption.
Proposed rescheduling would make it easier for scientists to acquire and study the drug
Intracellular tissue plasminogen activator in the endoplasmic reticulum of hepatocytes lowers circulating atherogenic cholesterol levels.
Noncanonical pentatricopeptide repeat-like RNA-binding proteins of the mitoribosome initiate plant mitochondrial protein translation.
Neural network predicts odors from chemical structures, speeding the search for new, better smelling consumer products
Our collective inaction on climate breakdown reflects in part our failure to acknowledge that the climate crisis is a crisis of inequality, and that solving the climate crisis is inextricably tied with the politics and economics of inequality. Put simply, redistribution from rich to poor, whether domestically or internationally, is a climate policy, and climate policies that inadvertently raise inequality are likely to be less effective than those that purposefully reduce it.
Direct estimates of mutation rates in four baleen whale species have wide-ranging evolutionary and conservation implications.
A severe bottleneck that brought human ancestors close to extinction occurred between about 930 and 813 thousand years ago.
Shifts in large-scale atmospheric circulation patterns have important consequences for Arctic climate.
Machine learning predictively recommends conditions for a widely used reaction that is sensitive to substrate structure.
Multiwavelength observations show that accretion onto a black hole was halted by a magnetic field in the accretion disk.
China is accelerating toward deeper offshore aquaculture (1) in an effort to diversify the food supply system to ensure domestic food security in the face of unstable international markets. However, offshore aquaculture presents risks that differ from those in nearshore fisheries (2, 3). The government and the aquaculture industry in China need to identify and address the unique challenges of offshore farms before expanding into deep water.
HomeScienceVol. 381, No. 6661Green decommissioning for renewables in ChinaBack To Vol. 381, No. 6661 Full accessLetter Share on Green decommissioning for renewables in ChinaSiyou Xia, Yu Yang [email protected], [...] , Yi Liu, and Jessie Poon+1 authors fewerAuthors Info & AffiliationsScience31 Aug 2023Vol 381, Issue 6661pp. 954-955 PREVIOUS ARTICLECoexistence at the crossroadsPreviousNEXT ARTICLE…
For the first time, ESA evaluations can include impacts on polar bears from greenhouse gas emissions
Yasmin Hurd sees growing evidence that exposure early in life can put kids at risk for drug and psychiatric problems later
Human and environmental health are inextricably linked. Yet ocean ecosystem health is declining because of anthropogenic pollution, overexploitation, and the effects of global climate change. These problems affect billions of people dependent on oceans ...
HomeScienceVol. 381, No. 6661How a component of cannabis could fight addictionBack To Vol. 381, No. 6661 Full accessFeature Share on How a component of cannabis could fight addictionIngrid WickelgrenAuthors Info & AffiliationsScience31 Aug 2023Vol 381, Issue 6661p. 939 PREVIOUS ARTICLESmoke AlarmPreviousNEXT ARTICLEThe climate crisis is a crisis of inequalityNext ContentsInformation & AuthorsMe…
A compelling new play revisits the discovery that drastically reduced maternal mortality
Ideology meets infrastructure for road ecologists helping flora and fauna live well in the presence of motorways
A draft industry standard could allow synthetic proteins to replace enzyme harvested from East Coast marine animals
Study identifies taste receptors that give our feline friends a craving for meat—and one fish in particular
Midnolin associates with the proteasome to promote degradation of nuclear proteins through a ubiquitination-independent mechanism.
CAF-1 binding primes histone H3-H4 heterodimers for tetramer assembly and assembles a right-handed nucleosome precursor.
While the world recovers from the COVID-19 pandemic, another crisis continues to spiral at a much faster speed than was expected. Climate change is dominating our lives and causing a high level of distress. Countries all over the world are struggling to ...
HomeScienceVol. 381, No. 6660Rerouting railway would conserve India’s gibbonsBack To Vol. 381, No. 6660 Full accessLetter Share on Rerouting railway would conserve India’s gibbonsRohit Ravindra Samita Jha, Gopi Govindan Veeraswami [email protected], [...] , Dilip Chetry, and Nandha Kumar+1 authors fewerAuthors Info & AffiliationsScience24 Aug 2023Vol 381, Issue 6660p. 843 PREVIOUS ARTICLESex Is a…
HomeScienceVol. 381, No. 6660Norway’s mining plans threaten Arctic lifeBack To Vol. 381, No. 6660 Full accessLetter Share on Norway’s mining plans threaten Arctic lifeChristian Sonne [email protected], Tomasz M. Ciesielski, [...] , Bjørn M. Jenssen, Su Shiung Lam, [...] , Huan Zhong, and Rune Dietz+3 authors +1 authors fewerAuthors Info & AffiliationsScience24 Aug 2023Vol 381, Issue 6660pp. 843-8…
Katavi National Park in western Tanzania is famed for its pristine remoteness and large mammal dry season aggregations (1, 2). Two unpaved roads of equivalent length run through the park, linking the regional capitals of Mpanda and Sumbawanga. One road cuts across the center of the park, crossing the Katuma River, a dry season hotspot for very large mammals, especially hippopotamus (3). The other runs farther west through miombo woodland with much lower animal densities. After a hiatus due to lack of funding, construction to pave the road that bisects the central area frequented by animals in the dry season has recently started, putting animal populations at risk. Yet Tanzania could still craft a win-win solution to this environment-development conflict if it reassesses its paving decision.
Solar Orbiter images reveal widespread magnetic plasma jets at the roots of the solar wind
Learning to appreciate the rarity of life could improve our climate future, argues a physicist
HomeScienceVol. 381, No. 6660Sex Is as Sex Does: Governing Transgender IdentityBack To Vol. 381, No. 6660 Full accessBooks et al.Podcast Share on Sex Is as Sex Does: Governing Transgender IdentityScience24 Aug 2023Vol 381, Issue 6660p. 842 PREVIOUS ARTICLEEmbrace the improbability of existencePreviousNEXT ARTICLERerouting railway would conserve India’s gibbonsNext ContentsBooksInformation & Aut…
The intestinal microbiota promotes lipid absorption and storage by repressing the expression of the long noncoding RNA gene Snhg9.
The addition of molybdenum to a nickel–bismuth catalyst lowers the temperature needed for methane pyrolysis.
Polyploidy, in which cells have bonus sets of chromosomes, is more prevalent and useful than researchers had thought
Driven by fierce winds and dry, hot conditions, the fire that consumed Maui’s Lahaina—the deadliest US fire in more than a century—is a sad, stark reminder of the environmental pressures on the Hawaiian islands caused by overdevelopment ...
HomeScienceVol. 381, No. 6660How bulked-up cells shape hearts and leavesBack To Vol. 381, No. 6660 Full accessFeature Share on How bulked-up cells shape hearts and leavesElizabeth PennisiAuthors Info & AffiliationsScience24 Aug 2023Vol 381, Issue 6660p. 828 PREVIOUS ARTICLEStress respondersPreviousNEXT ARTICLEWill climate change amplify epidemics and give rise to pandemics?Next ContentsInformat…
Physicists hope to pin down relative masses of wispy particles that change “flavors” on the fly
ATP generated with renewable power could potentially be used to manufacture proteins and medicines
Scientists and philosophers are proposing a checklist based on theories of human consciousness
As astronomers lose valuable windows for observations, cybersecurity experts wonder why hackers would target such facilities
In many parts of the world, secondary school science curricula continue to be dominated by learning objectives about scientific knowledge and investigations, when actually there is more to science. These curricula—the educational frameworks that include ...
Around 10,000 years ago, megafaunal losses in California were driven by fires in an ecosystem made vulnerable by climate change.
The human yolk sac is a key staging ground for an array of vital organ functions during development in utero.
The gaur (Bos gaurus), the largest living bovine species, primarily inhabits tropical and subtropical broadleaf forests, bamboo forests, and sparsely tree-covered grasslands (1). In China, the species is mainly found in Xishuangbanna Prefecture in Yunnan Province (1, 2). Anthropogenic changes have brought this population to the brink of extinction. China must take action to save this vulnerable megafauna.
Solar photovoltaic deployment is essential to promote renewable energy transition, phase down coal-fired power plants, and achieve the Paris Agreement temperature goals (1). However, large-scale solar photovoltaic deployment requires a vast amount of land, and a substantial number of solar photovoltaic projects have been built on farmland, threatening food security (2, 3). Given the ambitious climate pledges of signatory countries to the Paris Agreement, the area of land required to deploy global solar photovoltaics in the coming decades is expected to rise (4). Governments must act now to mitigate the fierce competition for land between solar energy and crops.
HomeScienceVol. 381, No. 6659The global impact of EU forest protection policiesBack To Vol. 381, No. 6659 Full accessLetter Share on The global impact of EU forest protection policiesGianluca Cerullo [email protected], Jos Barlow, [...] , Matthew Betts, David Edwards, [...] , Alison Eyres, Filipe França, Rachael Garrett, Thomas Swinfield, Eleanor Tew, [...] , Thomas White, and Andrew Balmford+8 a…
Environmental health research is being undermined by genomic medicine, argues a philosopher
Over the past 30 weeks, Israel has been undergoing an upheaval marked by unprecedented attacks by the government on the independence of its judiciary, attorney general, government legal advisers, police, military, public broadcasting, and religious ...
Lethal combination of climate change and human activity may have spurred fires 13,000 years ago
A type of oil-eating bacteria adapts its biofilm interfacial properties to accelerate the rate of oil consumption.
A two-state design of protein switches that couple effector binding to a conformational change is discussed.
Observations and models of a Wolf-Rayet star indicate that it will produce a magnetar when it explodes as a supernova.
Illumination with complex frequency waves can effectively compensate the losses in superlens materials.
POT1 binds the 5ʹ end of the telomeric double-strand–single-strand DNA junction to prevent human chromosome ends from being sensed as DNA damage.
The icosahedral C60 molecule’ s ability to thermalize its rotational degree of freedom can switch on and off as it spins up.
Low tide helped city dodge catastrophic 1964 wave, but future ones could destroy critical port, highways
Major NIH effort will probe the health effects of DNA changes acquired by only some tissues and organs
Blazes and high winds blew projects apart and left a tight-knit research community shaken. What will it take to prevent future island fires?
Alan Turing introduced his 1950 paper on Computing Machinery and Intelligence with the question “Can machines think?” But rather than engaging in what he regarded as never-ending subjective debate about definitions of intelligence, he instead proposed a ...
Phyloepigenetic trees derived from DNA methylation profiles mirror mammalian evolution and are related to traits including maximum life span.
CRISPR and flow cytometry approaches elucidate genes involved in the production of melanin in skin.
It’s been a bad few weeks for public perceptions of research integrity, as multiple cases at elite universities have received wide news coverage. Francesca Gino, a scientist at Harvard University, is in a legal dispute over whether data in newly retracted ...
HomeScienceVol. 381, No. 6658AustraliaBack To Vol. 381, No. 6658 Full accessIntroduction to Special IssueAustralia’s Environmental Challenges Share on Australia: Lessons from Ecosystems in CrisisCaroline Ash, Bianca Lopez, [...] , Ekeoma E. Uzogara, and Sacha Vignieri+1 authors fewerAuthors Info & AffiliationsScience10 Aug 2023Vol 381, Issue 6658pp. 614-615 NEXT ARTICLETaming the flame, from loca…
Humanity has inflicted widespread ecocide on global marine ecosystems since the industrial revolution (1). Indiscriminate dredging of the seabed has decimated thriving ecosystems and vast biogenic empires, leaving only barren sedimentary plains [e.g., (2)]. However, despite the extent of habitat loss and humanity’s increasing impact on the ocean, many marine habitats still demonstrate astonishing capacity for rapid recovery (3, 4). In southern Australia, for example, a rapid reversal of ecological extinction is underway.
HomeScienceVol. 381, No. 6658Begin ocean garbage cleanup immediatelyBack To Vol. 381, No. 6658 Full accessLetter Share on Begin ocean garbage cleanup immediatelyZouxia LongAuthors Info & AffiliationsScience10 Aug 2023Vol 381, Issue 6658pp. 612-613 PREVIOUS ARTICLEChina’s canal project threatens biodiversityPreviousNEXT ARTICLERapid reversal of ecological extinctionNext ContentsReferences and No…
HomeScienceVol. 381, No. 6658China’s canal project threatens biodiversityBack To Vol. 381, No. 6658 Full accessLetter Share on China’s canal project threatens biodiversityQiying Yang and Shanshan Yang [email protected]Authors Info & AffiliationsScience10 Aug 2023Vol 381, Issue 6658p. 612 PREVIOUS ARTICLELinnaeus and his life’s workPreviousNEXT ARTICLEBegin ocean garbage cleanup immediatelyNext …
A historian’s unvarnished biography reveals the complicated man who invented modern taxonomy
As antibiotic resistance soars, a journalist revisits an often overlooked antimicrobial strategy
Indigenous communities shoulder a disproportionate burden of ill health compounded by climate change. In Australia, the oldest surviving cultures have adapted their ecological knowledge over millennia and across climatic ages. However, European ...
Australia’s coastal marine ecosystems have a deep cultural significance to Indigenous Australians, include multiple World Heritage sites, and support the nation’s rapidly growing blue economy. Yet, increasing local pressures and global climate change are ...
Australia’s biota is species rich, with high rates of endemism. This natural legacy has rapidly diminished since European colonization. The impacts of invasive species, habitat loss, altered fire regimes, and changed water flows are now compounded by ...
Cherenkov Telescope Array will trace ferocious gamma ray light back to their cosmic sources
In just 2 weeks, unlikely “discovery” skyrockets to internet fame and then begins to fall back to Earth
Money woes and a staff strike threaten dispatches valued by researchers and public health experts
A study combined long-buried DNA and direct-to-consumer testing to uncover the lineage of free and enslaved African Americans.
First-of-its-kind project uses temperature sensors to track exposure in people trying to conceive
Human STING mediates proton leakage from the Golgi compartment for induction of LC3B lipidation and inflammasome activation.
Paneth cell–derived pancreatic polypeptide YY, in its full-length form, acts to check the invasive potential of commensal fungi.
A naturally occurring bacterium of anopheline mosquitoes produces an alkaloid that arrests the development of co-occurring Plasmodium oocytes
A two-gene signature from the tumor microenvironment of head and neck squamous cell carcinoma can predict tumor response to immunotherapy.
Brazil has committed to ambitious goals, including the reforestation of 12 million hectares (1). However, a recent proposal by Brazil’s Congress (2, 3) puts at risk the Atlantic Forest, one of the world’s most threatened biomes (4). The Provisional Measure (MP) 1150/2022 aims to change the Atlantic Forest Law (11.428/2006) and the Forest Code (12.651/2012) by loosening restrictions on removing native vegetation. After Brazil’s Chamber of Deputies and Senate approved the proposal in May, President Lula rejected it, but the Congress could overturn the presidential veto. National and international pressure are essential to persuade Brazil’s Congress to comply with the presidential veto and prevent further attacks to the Atlantic Forest.
After 4 years of regression in Brazil’s environmental policies, the administration of President Luiz Inácio Lula da Silva has been trying to resume an environmental agenda (1). However, the Brazilian Chamber of Deputies—led by Arthur Lira, a supporter of former President Jair Bolsonaro (2)—has recently approved a provisional measure (MP) and a bill, MP1154/2023 and PL490, that would hinder Brazil’s ability to control deforestation and threats to Indigenous lands. If these bills are approved by the Senate and signed into law by the president, global trade partners should reconsider their import agreements with Brazil.
HomeScienceVol. 381, No. 6657Silent summers: The decline of cicadasBack To Vol. 381, No. 6657 Full accessLetter Share on Silent summers: The decline of cicadasHong Yang [email protected], Xiaohua Xiang, [...] , Xiaoling Wu, Julian R. Thompson, and Roger J. Flower+2 authors fewerAuthors Info & AffiliationsScience3 Aug 2023Vol 381, Issue 6657p. 490 PREVIOUS ARTICLEDavid Bohm’s unfinished revolution…
An anniversary offers scientists an opportunity to revisit the work of an audacious physicist
Findings in marine mammals and birds provide opportunities to explore sleep’s functions
Genetics, ultraprocessed foods, portion distortion, sweetened beverages, screen time, food addiction, intestinal microbiota, diet culture, weight stigma, food insecurity—all have been implicated in the “obesity epidemic.” More than a billion people ...
When it comes to research, who speaks for the 19th century workers buried at Maryland’s Catoctin Forge?
Despite landmark antibody approval, research into potentially serious brain swelling and bleeding still lags
Government claims legislation is needed to fight climate change, but conservationists say it could accelerate deforestation
Biomedical group challenges listing cynomolgus macaques as endangered, arguing it could harm research
The TRIM11 protein is down-regulated in Alzheimer’s disease, and restoring its expression may lead to effective therapies.
Indo-European languages emerged south of the Caucasus around 8300 years ago, followed by an expansion northward to the Steppe regions.
But some are concerned about Meta’s role in the unusual collaboration between industry and academia
HomeScienceVol. 381, No. 6656Envisioning African Intersex: Challenging Colonial and Racist Legacies in South African MedicineBack To Vol. 381, No. 6656 Full accessBooks et al.Podcast Share on Envisioning African Intersex: Challenging Colonial and Racist Legacies in South African MedicineScience27 Jul 2023Vol 381, Issue 6656p. 382 PREVIOUS ARTICLEVenturing into the unfathomablePreviousNEXT ARTICLE…
The United States has lost vast amounts of historic wetlands. Twenty-two states have lost more than 50% of their wetland area, and some have lost more than 80% (1). In California, only 9% of the 5 million acres of wetlands that existed in 1850 remain (1, 2). The federal Clean Water Act (CWA) (3) has safeguarded US wetlands since 1972, but a recent Supreme Court decision removes the majority of US wetlands from federal protection.
We studied the effects of exposure to reshared content on Facebook during the 2020 US election by assigning a random set of consenting, US-based users to feeds that did not contain any reshares over a 3-month period. We find that removing reshared content ...
We investigated the effects of Facebook’s and Instagram’s feed algorithms during the 2020 US election. We assigned a sample of consenting users to reverse-chronologically-ordered feeds instead of the default algorithms. Moving users out of algorithmic ...
Does Facebook enable ideological segregation in political news consumption? We analyzed exposure to news during the US 2020 election using aggregated data for 208 million US Facebook users. We compared the inventory of all political news that users could ...
Did platform feeds sow the seeds of deep divisions during the 2020 US presidential election?
HomeScienceVol. 381, No. 6656One person’s trash: Another’s treasured educationBack To Vol. 381, No. 6656 Full accessLetterPast as Prologue Share on One person’s trash: Another’s treasured educationXiangkun Elvis Cao [email protected]Authors Info & AffiliationsScience27 Jul 2023Vol 381, Issue 6656p. 384 PREVIOUS ARTICLEKeep the Salween River free-flowingPreviousNEXT ARTICLEUS Supreme Court opinion…
HomeScienceVol. 381, No. 6656Keep the Salween River free-flowingBack To Vol. 381, No. 6656 Full accessLetter Share on Keep the Salween River free-flowingJuan Tao, Nick Bond, [...] , Nyo Nyo Tun, and Chengzhi Ding [email protected]+1 authors fewerAuthors Info & AffiliationsScience27 Jul 2023Vol 381, Issue 6656pp. 383-384 PREVIOUS ARTICLEEditor’s notePreviousNEXT ARTICLEOne person’s trash: Another’…
On 30 September 2021, Science published the Research Article “Light-induced mobile factors from shoots regulate rhizobium-triggered soybean root nodulation” by T. Wang et al. (1). On 30 June 2023, an Editorial Expression of Concern alerted readers that some missing data had been brought to the editors’ attention (2). The authors have now corrected the paper. As described in an Erratum (3), GmNIN expression data have been added to Fig. 5, and the supplementary materials have been updated. These changes have addressed concerns about the integrity of the paper. Therefore, Science has removed the Editorial Expression of Concern and posted this notification in its place to indicate the editors’ confidence in the Research Article’s data and conclusions. We thank the community for bringing these issues to our attention.
When TheFacebook.com went live in February of 2004, social media quickly became an integral part of life. Old friends rediscovered each other, pet photography flourished, and the way human attention on the internet was distributed was altered forever. As ...
Soil carbon credits are gaining popularity, but some researchers say they rest on shaky science
Philadelphia’s tourist hot spot launches an ethical review of its anatomical curiosities—and sets off a firestorm
Applying deep learning models to x-ray imaging data elucidates relationships between and the genetic basis for skeletal proportions.
A host’s immune responses may shape its microbiota, but the microbiota are just as likely to shape the host’s responses.
New tools can guide US policies to better target and reduce racial and socioeconomic disparities in air pollution exposure
Minimally invasive probes delivered into the brain vasculature monitor neural activity in vivo without causing damage.
Massive amounts of data and countless analyses collected across decades of scholarly research demonstrate unequivocally that bias and inequity based on race (in other words, racism) have occurred and still occur throughout society in the United States (...
HomeScienceVol. 381, No. 6655Abandoned land: Linked to biological invasionsBack To Vol. 381, No. 6655 Full accessLetter Share on Abandoned land: Linked to biological invasionsMagdalena Lenda [email protected], Piotr Skórka, [...] , Hugh P. Possingham, and Johannes M. H. Knops+1 authors fewerAuthors Info & AffiliationsScience20 Jul 2023Vol 381, Issue 6655p. 277DOI: 10.1126/science.adi7833 PREVIOUS…
In their Perspective “Abandoning land transforms biodiversity” (12 May, p. 581), G. N. Daskalova and J. Kamp suggest that rural depopulation, environmental degradation, and other factors have led to vast areas of land globally that are available for restoration. We agree that careful planning and management are needed to conserve biodiversity on lands where human activities have ceased. However, by oversimplifying the socioeconomic processes that affect whether land is truly abandoned, the authors overestimate the potential of these lands for biodiversity conservation.
The views of Lenda et al. and Holl et al. about land abandonment, biodiversity, and people largely align with ours. To advance our understanding of the short- and long-term impacts of abandonment, biodiversity research and policy should explicitly define spatial, temporal, and taxonomic scales; distinguish between passive and active management of abandoned land; and acknowledge differences in landscape heterogeneity and socioeconomic context.
Global Positioning System (GPS) measurements suggest hours-long precursors to many large earthquakes
New proposed legislation on “forever” chemicals is under consideration in Europe and the United States, where per- and polyfluoroalkyl substances (PFAS) are a hot topic for regulators and lawmakers. On both sides of the Atlantic, regulation of widely used ...
An accessible introduction to computational cosmology offers fodder for profound reflection
In humans and in mouse models, pineal gland denervation by immune cells causes sleep disturbance in cardiac disease.
Photocatalysis increased concentration gradients of iron cyanide anions and the thermopower of a thermogalvanic device.
High-time-rate GPS time series have a precursor signal for large earthquake rupture starting approximately 2 hours beforehand.
A versatile inorganic fluorinating reagent is prepared by mechanochemical activation of fluorspar with a phosphate salt.
A network of thousands of coders and researchers is working to develop translation tools that understand their native languages
Researchers are fighting back against a mysterious conference organizer and an arbitration court that may not exist
Papers withdrawn after Harvard Business School investigation of behavioral scientist Francesca Gino uncovers “manually changed” data
Researchers concerned about harm to diverse and mysterious ecosystems, as International Seabed Authority fails to reach agreement
A-bomb architect “was no Einstein,” historian says, but he did Nobel-level work on black holes
House defense bill would vastly expand information that must be disclosed and posted online
Despite advances in molecular biology, genetics, computation, and medicinal chemistry, infectious disease remains an ominous threat to public health. Addressing the challenges posed by pathogen outbreaks, pandemics, and antimicrobial resistance will ...
There is more to art than AI-created artifacts, but computational creativity is worth pursuing
Promoting equity in AI in health care requires addressing biases at cli nical implementation
AI-predicted race variables pose risks and opportunities for studying health disparities
In 1967, Marvin Minksy, a founder of the field of artificial intelligence (AI), made a bold prediction: “Within a generation…the problem of creating ‘artificial intelligence’ will be substantially solved.” Assuming that a generation is about 30 years, ...
Rapid, widespread adoption of the latest large language models has sparked both excitement and concern about advanced artificial intelligence (AI). In response, many are looking to the field of AI safety for answers. Major AI companies are purportedly ...
Density functional theory (DFT) plays a pivotal role in chemical and materials science because of its relatively high predictive power, applicability, versatility, and computational efficiency. We review recent progress in machine learning (ML) model ...
HomeScienceVol. 381, No. 6654News at a glanceBack To Vol. 381, No. 6654 Full accessIn BriefSCI COMMUN Share on News at a glanceScience13 Jul 2023Vol 381, Issue 6654pp. 112-113 PREVIOUS ARTICLENew options for patenting in EuropePreviousNEXT ARTICLEAnthropocene’s emblem may be Canadian pondNext ContentsEurope considers loosening rules on gene-edited cropsNIH ends funding for troubled monkey labU.…
Inventors seeking to protect their intellectual property in Europe now have an important choice to make. More than a decade after its approval, a new patent system came into effect last month, which some European Union (EU) countries already have signed ...
A journalist documents the struggle to catch, tag, and restore populations of Atlantic bluefin tuna
Eerily realistic simulated personas could save researchers time and money—or stand in for people in dangerous experiments
HomeScienceVol. 381, No. 6654Artificial intelligence meets medical roboticsBack To Vol. 381, No. 6654 Full accessPerspectivePerspective Share on Artificial intelligence meets medical roboticsMichael Yip [email protected], Septimiu Salcudean [email protected], [...] , Ken Goldberg [email protected], Kaspar Althoefer [email protected], [...] , Arianna Menciassi [email protected], Justin D. Opferman…
HomeScienceVol. 381, No. 6654AI in search of human helpBack To Vol. 381, No. 6654 Full accessLetterNextGen Voices Share on AI in search of human helpAshley Barbara Heim [email protected], Tina Bharani [email protected], [...] , Nikos Konstantinides, Jackson Ross Powell [email protected], [...] , Sudhakar Srivastava [email protected], Xiangkun Elvis Cao [email protected], Divyansh Agarwal, Khor Wa…
Proposed National Research Foundation would spend $6 billion over 5 years, but is drawing mixed reactions
Proposal for Canada’s Crawford Lake to mark global changes of the 1950s now faces skeptical scientific bureaucracy
Structural analysis of the RNA editosome reveals mechanisms of guide RNA recognition and messenger RNA engagement.
Interactions between plant-associated bacteria are recapitulated by experimentally informed genome-scale metabolic models.
Early-season warming hastens onset and late-season warming extends duration of autumn leaf senescence in northern forests.
High-resolution cryo–electron microscopy structures of human ribosomal pre-60S particles elucidate principles of eukaryotic ribosome assembly.
A deep dive into the eight living bear species emphasizes humanity’s role in their fate
Spectroscopy of molecular ions of hafnium fluoride was used to deduce the asymmetry of the electron’s charge distribution.
Adding composition complexity to a known crystal framework enables millimeter-thick battery electrodes.
Positioning asymmetric cell divisions allows for the inheritance of stomatal polarity markers in Arabidopsis thaliana leaf epidermis.
New methods are emerging to quantify human and animal welfare on a common scale, creating new tools for policy
Surface treatment of triple-halide perovskite layers with piperazinium iodide enables highly efficient tandem solar cells.
Phosphonic acids minimize charge-transfer losses and improve coating of perovskites on micropyramidal silicon substrates.
HomeScienceVol. 381, No. 6653Succinct discoveries that inspireBack To Vol. 381, No. 6653 Full accessLetterNextGen Voices Share on Succinct discoveries that inspireScience6 Jul 2023Vol 381, Issue 6653pp. 24-25 PREVIOUS ARTICLEAltering Earth in our imagePreviousNEXT ARTICLEThe sound of silenceNext ContentsNeuroscienceImmunologyInfectious DiseaseBiologyGeneticsEcologySocial ScienceChemistryPhysics…
In the past few years, museums around the world have started to grapple with questions about the origins and ethics of their collections. This includes the acquisition and maintenance of natural history specimens. As museums examine their missions and ...
With three DIY observatories across Japan, Koichi Itagaki spots starbursts before the professionals
Studies probe unusual cases of neurologic complications, blood pressure swings, and other side effects
Equity advocates see path to increasing minority representation—but say it won’t be easy
Mavericks, virus-like transposons, gained a fusogen in nematodes and became a recurrent vector of horizontal gene transfer.
RIBOmap enables single-cell in situ profiling of mRNA translation in 3D for thousands of genes in intact cells and tissues.
The Hindu Kush-Himalaya region (HKH) is one of the most biodiverse places in the world. The area hosts four global biodiversity hotspots (1) as well as 12 terrestrial and 5 freshwater Global 200 Ecoregions (2), yet multiple species are at risk of imminent extinction (3). Both physical barriers and policy differences across international borders hinder conservation efforts. Protecting the region’s biodiversity will require multilateral cooperation.
HomeScienceVol. 380, No. 6652A family’s pride in educated daughtersBack To Vol. 380, No. 6652 Full accessLetterPast as Prologue Share on A family’s pride in educated daughtersQura Tul Ain [email protected]Authors Info & AffiliationsScience29 Jun 2023Vol 380, Issue 6652p. 1331DOI: 10.1126/science.adi2884 PREVIOUS ARTICLEBorder conservation in Hindu Kush-HimalayaPreviousNEXT ARTICLEIn Science Journ…
Protein kinases control a metabolic checkpoint that dictates cell responses to metabolic stress.
A class of cyanotriazole drugs that provide fast-acting trypanosomatid-specific topoisomerase II inhibitors was identified.
Converting plains to agriculture creates shallow water tables and increased flooding at the subcontinent scale.
Simulations of Mars’ past climate show that water could have been a liquid at the locations where gullies formed.
Astrophysical neutrinos are emitted from the plane of the Milky Way galaxy, implying the presence of nearby sources.
Encounter times of chromosomal DNA loci are much less dependent on genomic distance than predicted by existing polymer models.
Since April, India has been roiled by controversy around the excision of several topics, including evolution and the periodic table, from school textbooks (up to grade 10) by the National Council for Educational Research and Training (NCERT). This was ...
Economy-wide emissions drop 43 to 48% below 2005 levels by 2035 with accelerated clean energy deployment
Reflecting on humanity’s intertwined history with water, a scientist offers actionable advice for meeting future needs
HomeScienceVol. 380, No. 6652Killing the Black Body: Race, Reproduction, and the Meaning of LibertyBack To Vol. 380, No. 6652 Full accessBooks et al.Podcast Share on Killing the Black Body: Race, Reproduction, and the Meaning of LibertyScience29 Jun 2023Vol 380, Issue 6652p. 1329DOI: 10.1126/science.adj1265 PREVIOUS ARTICLEThalidomide in AmericaPreviousNEXT ARTICLEWill Canada permit killer whale …
HomeScienceVol. 380, No. 6652Will Canada permit killer whale extinction?Back To Vol. 380, No. 6652 Full accessLetter Share on Will Canada permit killer whale extinction?Misty MacDuffee [email protected], Lance Barrett-Lennard, [...] , Auston Chhor, Allison M. Dennert, [...] , Peter S. Ross, David C. Scott, Valeria Vergara, and Kristen Walters+5 authors +3 authors fewerAuthors Info & AffiliationsS…
Still wary of COVID-19, Jeremy Farrar wants to bring a “sense of tomorrow” to health agency and countries
Subtle shifts in stellar signals reveal pervasive waves from mergers of giant black holes
Two rival theories about the basis of perception went head-to-head in neuroscience experiments, but advocates of “losing” idea aren’t conceding yet
Ben Hu denies he was sick in late 2019, or that his coronavirus work led to COVID-19, and newly declassified U.S. intelligence doesn’t substantiate allegations against him
Diverse neural wiring patterns emerge from differential regulation of cohesin-mediated DNA loop extrusion by the cohesin release factor WAPL.
A review describes the challenges facing the search for an elusive class of quasiparticles.
Endoplasmic reticulum–specific variants explain MFN2 function beyond mitochondria and its role in the pathogenesis of nonalcoholic steatohepatitis.
Weak cross-linkers can improve the ultimate strength and tear resistance of polymer networks.
HomeScienceVol. 380, No. 6651New farmlands threaten the North China leopardBack To Vol. 380, No. 6651 Full accessLetter Share on New farmlands threaten the North China leopardXianghong Dong and Tao Ju [email protected]Authors Info & AffiliationsScience22 Jun 2023Vol 380, Issue 6651p. 1230 PREVIOUS ARTICLEChina’s water diversion carries invasive speciesPreviousNEXT ARTICLEIn Science JournalsNext …
The Chinese government has constructed the world’s largest water conservancy initiative, the South-to-North Water Diversion Project, to address drought and water scarcity in northern China (1, 2). The project encompasses an area with 438 million inhabitants and spans a total of 4350 km across its eastern, middle, and western routes. As of March, the cumulative water diversion volume of the eastern and middle routes has surpassed 61.2 billion cubic meters (3). Although the project has generated substantial economic benefits, it has also provided a path for biological invasions (4). The Chinese government must take urgent action to stop invasive species from infiltrating water diversion canals and mitigate the harm they cause if they are transported to northern regions.
A biologist captures the humanity of scientific research in a play about the AIDS crisis
HomeScienceVol. 380, No. 6651Sound stewardship for a noisy planetBack To Vol. 380, No. 6651 Full accessLetter Share on Sound stewardship for a noisy planetMatthias C. Rillig [email protected], Michael S. Bank, [...] , Stefanie Maaβ, Mélia Roger, and Marcus Maeder+2 authors fewerAuthors Info & AffiliationsScience22 Jun 2023Vol 380, Issue 6651p. 1219 PREVIOUS ARTICLEAn ode to owlsPreviousNEXT ARTIC…
Fluorescence lifetime was captured at kilohertz frame rates, providing a readout for neural activity that surpasses standard measurements.
Internal twists in a mutant carnivorous plant reveal how genes control growth coordination via tissue mechanics.
Elucidating the mechanism underlying how newly synthesized proteins are sorted into the correct protein biogenesis pathway at the ribosome.
The hierarchical structure design found in a mineralized tissue integrates functionality and inherent fatigue tolerance.
The pore-forming protein perforin-2 is a dedicated effector of endocytic escape specific to cross-presenting cells.
Space survey will help determine if puzzling antigravitational force is vacuum energy, a new force, or modified gravity
Perforin-2 facilitates antigen translocation to the cytosol in cross-presenting dendritic cells
Survey shows few societies are pulling out of affected U.S. states, but many are implementing safety measures
The Aging Fly Cell Atlas reveals the transcriptional changes across tissues over the lifetime of a hallmark model organism, Drosophila melanogaster.
Understanding the causes and potential mitigations of light pollution requires measuring and monitoring artificial light at night (ALAN). We review how ALAN is measured, both from the ground and through remote sensing by satellites in Earth orbit. A ...
HomeScienceVol. 380, No. 6650Address the Aral Sea crisis with cooperationBack To Vol. 380, No. 6650 Full accessLetter Share on Address the Aral Sea crisis with cooperationLei Wang [email protected], Zhenyong Zhao, [...] , Khabibullo Shomurodov, and Changyan Tian+1 authors fewerAuthors Info & AffiliationsScience15 Jun 2023Vol 380, Issue 6650p. 1114 PREVIOUS ARTICLENine livesPreviousNEXT ARTICLEPro…
The United Nations’ Sustainable Development Goal 2 focuses on efforts to “end hunger, achieve food security and improved nutrition, and promote sustainable agriculture,” (1) but progress has been insufficient to meet these goals by 2030. The cost of healthy, nutritious food is a major barrier to adequate nutrition, especially in low-income countries (1). To address malnutrition and food insecurity, national governments, with assistance from development partners and technical experts, must reform and strengthen agrifood systems to make low-cost, nutrient-dense foods affordable to all.
Brains begin with complete models of the world and work backward to anticipate sensory data, argues a philosopher
HomeScienceVol. 380, No. 6650Losing the darknessBack To Vol. 380, No. 6650 Full accessIntroduction to Special Issue Share on Losing the darknessKeith T. Smith https://orcid.org/0000-0002-3683-1661, Bianca Lopez https://orcid.org/0000-0003-3864-5042, [...] , Sacha Vignieri https://orcid.org/0000-0003-4716-796X, and Brad Wible https://orcid.org/0009-0005-6994-4805+1 authors fewerAuthors Info & Affi…
Nocturnal light pollution can have profound effects on humans and other organisms. Recent research indicates that nighttime outdoor lighting is increasing rapidly. Evidence from controlled laboratory studies demonstrates that nocturnal light exposure can ...
Anthropogenic light is ubiquitous in areas where humans are present and is showing a progressive increase worldwide. This has far-reaching consequences for most species and their ecosystems. The effects of anthropogenic light on natural ecosystems are ...
Understanding shifts in creative work will help guide AI’s impact on the media ecosystem
A stable compound featuring a beryllium-beryllium bond has been synthesized and characterized in solution and solid state.
The starry sky has been a source of inspiration throughout human history. Astronomy has been a common element in all cultures and civilizations, being used to establish calendars, navigate and discover new lands, and drive numerous scientific and ...
Protecting fragile mountaintop ecosystems is a crucial component of the Sustainable Development Goals of the United Nations’ 2030 Agenda for Sustainable Development (1). Mountaintops are among the ecosystems most vulnerable to climate change (2–4). Global warming could lead to the extinction of about 10% of eukaryotic species on Earth by 2100 (5). Mountaintop ecosystems preserve vast amounts of biodiversity that lives in extreme environmental conditions, provide food and water for human well-being, and are important for global carbon storage (6). Thus, they have irreplaceable economic and ecological values in the biodiversity, stability, and sustainability of global and local ecosystems. The protection of mountaintop ecosystems needs a targeted conservation framework.
Natural colorant that took decades to develop now faces ethical and commercial uncertainties
Vulnerabilities of the world’s least developed countries to health, economic, and environmental crises were recently in the spotlight at a United Nations (UN) conference in Qatar. In March, the Doha Programme of Action was announced as a call for the ...
HomeScienceVol. 380, No. 6650News at a glanceBack To Vol. 380, No. 6650 Full accessIn BriefSCI COMMUN Share on News at a glanceScience15 Jun 2023Vol 380, Issue 6650pp. 1092-1093 PREVIOUS ARTICLECommit to the Global SouthPreviousNEXT ARTICLEHow the molecules of life became one-handedNext ContentsConcussion experts call for rule changesOcean mining ban soughtDiabetes drug deters Long CovidGlobal …
Research shows structural racism in 1900s U.S. society harmed Black health in ways still being felt today
Taurine supplementation extends healthy lifespan in worms, rodents, and non-human primates.
The MAdCAM-1– α4β7 interaction is a gut immune checkpoint for cancer immunosurveillance.
New view of molecule’s good side has inspired South Korean company to plan testing a synthetic version in people
In 1968, Martin Luther King Jr. professed, “We’ve got some difficult days ahead. But it really doesn’t matter with me now, because I’ve been to the mountaintop…. And I’ve seen the Promised Land.” Sadly, 55 years later, the United States may have future ...
Plants modified to grow in the dark could also provide fresh produce in extreme environments on Earth
An ambitious “big history” of climate and civilization falls victim to the perils of the genre
Chemical reactions can be accelerated by directional local pressure applied to molecules
Looking at policies instead of promises shows that global climate targets may be missed by a large margin
HomeScienceVol. 380, No. 6649Green energy projects at odds with conservationBack To Vol. 380, No. 6649 Full accessLetter Share on Green energy projects at odds with conservationVernon C. Bleich [email protected], Christina M. Aiello, [...] , Clinton W. Epps, and John D. Wehausen+1 authors fewerAuthors Info & AffiliationsScience8 Jun 2023Vol 380, Issue 6649p. 1021DOI: 10.1126/science.adi0761 PREVI…
The United Nations identifies the drivers of the planetary crisis as climate change, biodiversity loss, and pollution (1). Mitigation requires reliable science to inform decision-making. However, relevant research is often underutilized in policy planning and implementation because policy-making entities limit the ability of scientists to contribute to the process (2, 3).
The National Institutes of Health (NIH), in an effort to ensure equity and reduce bias, has proposed a plan to change how grant proposals are peer reviewed (1). However, the proposed changes do not address previous evidence about bias in the peer review process, and the agency has not specified how it plans to evaluate progress. NIH should ensure that the policies and practices that control the conduct and communication of grant reviews are informed by evidence and subject to accountability.
Field observations show that the distribution of African forest and savanna are highly predictable based on climate.
Artificial atoms created from cesium ions on an InSb(110) surface can be used to emulate the molecular orbitals of organic molecules.
A beam splitter for phonons completes the toolbox required to develop a mechanically based quantum computing system.
Real-time switching studies in wurtzite ferroelectrics reveal that an antipolar metastable state mediates polarization inversion.
Prodigious self-citation enables Saveetha Dental College to top global lists, investigation finds
Mouse study identifies separate mechanisms behind psychedelics’ antidepressant and hallucinogenic effects, providing target for future drug development
Anthropologists praise Homo naledi fossils but doubt spectacular claims of intentional burial and art
Study points to cheap way to sniff out past and present species from DNA snagged in air filters
We examined 454,712 exomes for genes associated with a wide spectrum of complex traits and common diseases and observed that rare, penetrant mutations in genes implicated by genome-wide association studies confer ~10-fold larger effects than common ...
Incomplete lineage sorting (ILS) causes the phylogeny of some parts of the genome to differ from the species tree. In this work, we investigate the frequencies and determinants of ILS in 29 major ancestral nodes across the entire primate phylogeny. We ...
Biobank-scale imaging traits reveal phenotypic and genetic links between the human heart and brain.
Baboons (genus Papio) are a morphologically and behaviorally diverse clade of catarrhine monkeys that have experienced hybridization between phenotypically and genetically distinct phylogenetic species. We used high-coverage whole-genome sequences from ...
The biological mechanisms that underpin primate social evolution remain poorly understood. Asian colobines display a range of social organizations, which makes them good models for investigating social evolution. By integrating ecological, geological, ...
Hybridization is widely recognized as promoting both species and phenotypic diversity. However, its role in mammalian evolution is rarely examined. We report historical hybridization among a group of snub-nosed monkeys (Rhinopithecus) that resulted in the ...
Personalized genome sequencing has revealed millions of genetic differences between individuals, but our understanding of their clinical relevance remains largely incomplete. To systematically decipher the effects of human genetic variants, we obtained ...
The rich diversity of morphology and behavior displayed across primate species provides an informative context in which to study the impact of genomic diversity on fundamental biological processes. Analysis of that diversity provides insight into long-...
Scientific research is a social process that occurs over time with many minds contributing. But the public has been taught that scientific insight occurs when old white guys with facial hair get hit on the head with an apple or go running out of bathtubs ...
The first U.S. nationwide geological survey in a generation could reveal badly needed supplies of critical minerals
HomeScienceVol. 380, No. 6648Summer reading 2023Back To Vol. 380, No. 6648 Full accessBooks et al.Review RoundUpSummer reading 2023Robert Frederick [email protected], Elie Dolgin [email protected], [...] , Dan Blustein [email protected], Francisco J. Guerrero [email protected], [...] , Lisa Aziz-Zadeh [email protected], Stephani Sutherland [email protected], Clare Fieseler [email protected], Brid…
A new method offers high-resolution three-dimensional printing and low-temperature firing
HomeScienceVol. 380, No. 6648Improve energy-efficient construction in ChinaBack To Vol. 380, No. 6648 Full accessLetterImprove energy-efficient construction in ChinaXinbo Xu and Zhiwei Lian [email protected]Authors Info & AffiliationsScience1 Jun 2023Vol 380, Issue 6648p. 902 PREVIOUS ARTICLESummer reading 2023PreviousNEXT ARTICLEResearchers need better access to US Census dataNext ContentsRefe…
The US Census Bureau decided to adopt a differential privacy framework by adding noise to the 2020 Census data to improve the confidentiality of individual Census responses (1). To protect the collected data, random noise was added to the tabulated statistics, and the data and noise were stored together in a Noisy Measurement File (NMF). The NMF is critical for understanding biases in the Census data and for performing valid statistical inferences, as it potentially allows data users to adjust for the noise in their analyses. However, in 2021, the Census Bureau released only the final tabulated statistics that were produced after postprocessing the NMF (1). This postprocessing ensured the final published data met data consistency requirements (such as nonnegative population counts), but it may have also introduced systematic biases (2–7). The Census Bureau must provide data users access to the NMF in usable form to facilitate the wide array of use cases for Census data.
During the United Nations Biodiversity Conference (COP15) in December 2022, nearly 200 countries, including Chile, agreed to halt biodiversity loss by 2030 and to take urgent actions to stop the extinction of endangered species. Despite this commitment, the Chilean government is pushing for the construction of a road that would cross the Alerce Costero National Park (1), an area of global importance for biodiversity conservation (2) and home to the endangered conifer Fitzroya cupressoides (3). Throughout the world, roads threaten biodiversity and ecosystem functions (4). Before pushing this project ahead, Chile should consider the likelihood that the road will undermine the country’s progress toward international environmental commitments.
HomeScienceVol. 380, No. 6648Understanding our own orderBack To Vol. 380, No. 6648 Full accessIntroduction to Special IssueUnderstanding our own orderSacha VignieriAuthors Info & AffiliationsScience1 Jun 2023Vol 380, Issue 6648pp. 904-905 NEXT ARTICLEA global catalog of whole-genome diversity from 233 primate speciesNext ContentsInformation & AuthorsMetrics & CitationsView OptionsReferencesMedi…
Comparative analysis of primate genomes within a phylogenetic context is essential for understanding the evolution of human genetic architecture and primate diversity. We present such a study of 50 primate species spanning 38 genera and 14 families, ...
Scientists oppose U.S. Geological Survey plan to reduce scope and frequency of chemical database
Agency says it has brought more than 200 tardy investigators into compliance since July 2022
The 19S subcomplex of the proteasome functions without its 20S partner to regulate synapses.
Microbial communities sourced from more extreme climates can help tree seedlings tolerate cold and drought.
Introducing copper to a sodium-doped tin selenide improves the room temperature thermoelectric properties.
As Alaskan soils have warmed over the past 25 years, hibernating arctic ground squirrel females, but not males, are ending hibernation earlier.
In March, Science published a news story by Jeffrey Mervis that chronicled five cases of individuals, mostly Chinese or of Chinese descent, whose research careers were disrupted or ended by personnel actions taken by the US National Institutes of Health (...
A wildfire in a Canadian oil town offers a case study in fossil fuels and climate change
HomeScienceVol. 380, No. 6647The Female Turn: How Evolutionary Science Shifted Perceptions About FemalesBack To Vol. 380, No. 6647 Full accessBooks et al.PodcastThe Female Turn: How Evolutionary Science Shifted Perceptions About FemalesScience25 May 2023Vol 380, Issue 6647p. 802DOI: 10.1126/science.adi5088 PREVIOUS ARTICLEAdding fuel to the firesPreviousNEXT ARTICLEUS benefit-cost analysis requir…
HomeScienceVol. 380, No. 6647US benefit-cost analysis requires revisionBack To Vol. 380, No. 6647 Full accessLetterUS benefit-cost analysis requires revisionPeter H. Howard [email protected], Max Sarinsky, [...] , Michael Bauer, Caroline Cecot, [...] , Maureen Cropper, Moritz Drupp, Mark Freeman, Kenneth T. Gillingham, Christian Gollier, [...] , Ben Groom, Qingran Li, Michael Livermore, Richard N…
On behalf of the Society of Chinese Bioscientists in America, the Asian American Scholar Forum, the Chinese American Hematologist and Oncologist Network, and the Chinese Biological Investigators Society, we applaud the News Feature “Pall of suspicion” (J. Mervis, 24 March, p. 1180) and accompanying Editorial, “Eroding trust and collaboration” (H. H. Thorp, 24 March, p. 1171). These articles revealed secretive and widespread investigations of Chinese American scholars prompted by the National Institutes of Health (NIH) under what Mervis described as “NIH’s China Initiative.” As Mervis explains, “81% of the scientists cited in the NIH letters identify as Asian,” and hundreds of Chinese American scholars’ lives and careers have been disrupted or ruined. The Department of Justice’s original “China Initiative,” launched in 2018 to protect national security, raised concerns that Asian Americans and immigrants were being profiled. Although there have since been positive changes to that program (1), both scientists and nonscientists in the United States must remain vigilant to ensure that history does not repeat itself.
In his News Feature “Pall of suspicion” (24 March, p. 1180), J. Mervis describes 5 of the 246 cases in which the US National Institutes of Health (NIH) suspected that scientists were violating grant funding policies. Mervis insinuates that the cases were mishandled and unjustified, but the data he cites show that NIH had well-founded concerns. In over 60% of the 246 cases, institutional investigations resulted in employment termination or future grant ineligibility, whereas institutions found no evidence of wrongdoing in only 6% of cases. Mervis characterizes the investigations as secretive, but the lack of transparency can be explained by privacy considerations, which prevented NIH from disclosing details about the evidence leading to concerns about these 246 scientists. Although nondisclosure of details to the public may have led to misunderstandings among those not directly involved, NIH followed appropriate procedures and guidelines to protect the integrity of its funding.
Shallow submarine hydrothermal vents can supply the iron needed to fuel phytoplankton blooms.
Activated T cell receptors are shed through ectocytosis, not endocytosis, at the immune synapse.
The addition of lead chelation molecules into the hole-transport layer of perovskite solar cells improves module performance.
Motility and responses to cell-cell contact are responsible for aggregation in the nitrogen-fixing cyanobacterium Trichodesmium.
By specializing for catching, ingesting, and swallowing all sorts of food, tongues had dramatic impact on animal evolution
As pandemic slows and COVID-19 funding dwindles, researchers worry companies won’t have incentives to bring improved antibodies to market
Use of viruses poses significant risks and, for now, prevents retreatment if benefits fade
Use of highly enriched fuel in civilian reactor would contravene decades-old nonproliferation policy
As Omicron persists, consensus grows for abandoning the ancestral coronavirus strain to improve immune responses
Information theory is used to design robots with guaranteed arrival over noisy terrain.
Autologous hematopoietic stem cell transplantation is effective, but mechanisms are elusive
The incomplete removal of T cells that are reactive against self-proteins during their differentiation in the thymus requires mechanisms of tolerance that prevent their effector function within the periphery. A further challenge is imposed by the need to ...
Although all multicellular organisms have germ line–encoded innate receptors to sense pathogen-associated molecular patterns, vertebrates also evolved adaptive immunity based on somatically generated antigen receptors on B and T cells. Because randomly ...
Autoimmune diseases display a high degree of comorbidity within individuals and families, suggesting shared risk factors. Over the past 15 years, genome-wide association studies have established the polygenic basis of these common conditions and revealed ...
Streams of intergalactic gas enriched by previous star formation were observed spiraling toward a massive galaxy.
Models sugg est that at least 10.5 million children experienced COVID-19–associated orphanhood and caregiver loss in the first 2 years of the pandemic (1), and the numbers continue to grow (2). However, public health data cannot identify children experiencing orphanhood. More information about such children could facilitate the delivery of support, services, and loving care, minimizing the negative effects of orphanhood (3–5). To obtain this data, death certificates should include the number of children under the age of 18 living in the home of the deceased parent or caregiver.
Addressing global warming requires increased investment in conserving and restoring carbon-dense natural habitats. Some companies that emit carbon have turned to certified carbon credits to offset their environmental impact. However, the effectiveness of carbon credits depends on the methods used to quantify them. If carbon credits do not accurately represent their environmental benefits, relying on them could exacerbate climate change (1). To ensure that carbon credits are robust, the methods used to calculate them must be improved.
HomeScienceVol. 380, No. 6644When a delicate balancing act goes wrongBack To Vol. 380, No. 6644 Full accessIntroduction to Special Issue Share on When a delicate balancing act goes wrongGemma Alderton and Seth Thomas ScanlonAuthors Info & AffiliationsScience4 May 2023Vol 380, Issue 6644pp. 468-469DOI: 10.1126/science.adi2318 NEXT ARTICLEResetting tolerance in autoimmune diseaseNext ContentsInfo…
HomeScienceVol. 380, No. 6644Protect old-growth forests in Europe nowBack To Vol. 380, No. 6644 Full accessLetter Share on Protect old-growth forests in Europe nowMartin Mikolāš [email protected], Gianluca Piovesan, [...] , Anders Ahlström, Daniel C. Donato, [...] , Rhiannon Gloor, Jeňýk Hofmeister, William S. Keeton, Bart Muys, Francesco M. Sabatini, [...] , Miroslav Svoboda, and Tobias Kuemmerl…
A large-scale experiment focused on social belonging shows impacts on first-year full-time completion
An anticannibalistic signaling pathway offers a new understanding of locust swarm formation
Though therapies may come too late for him, Tim Greenamyre sees hope on the horizon for patients
Impasse after Ukraine invasion threatens long-running data sets in oceanography, ecology, and climate science
Pioneering technique allows scientists to read genetic traces of an artifact’s last user
We examined transposable element (TE) content of 248 placental mammal genome assemblies, the largest de novo TE curation effort in eukaryotes to date. We found that although mammals resemble one another in total TE content and diversity, they show ...
Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single ...
Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least 332 million bases (~10.7%) in the ...
The precise pattern and timing of speciation events that gave rise to all living placental mammals remain controversial. We provide a comprehensive phylogenetic analysis of genetic variation across an alignment of 241 placental mammal genome assemblies, ...
Protein-coding differences between species often fail to explain phenotypic diversity, suggesting the involvement of genomic elements that regulate gene expression such as enhancers. Identifying associations between enhancers and phenotypes is challenging ...
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of ...
Understanding the regulatory landscape of the human genome is a long-standing objective of modern biology. Using the reference-free alignment across 241 mammalian genomes produced by the Zoonomia Consortium, we charted evolutionary trajectories for 0.92 ...
Conserved genomic sequences disrupted in humans may underlie uniquely human phenotypic traits. We identified and characterized 10,032 human-specific conserved deletions (hCONDELs). These short (average 2.56 base pairs) deletions are enriched for human ...
Annotating coding genes and inferring orthologs are two classical challenges in genomics and evolutionary biology that have traditionally been approached separately, limiting scalability. We present TOGA (Tool to infer Orthologs from Genome Alignments), a ...
Thousands of genomic regions have been associated with heritable human diseases, but attempts to elucidate biological mechanisms are impeded by an inability to discern which genomic positions are functionally important. Evolutionary constraint is a ...
Human accelerated regions (HARs) are conserved genomic loci that evolved at an accelerated rate in the human lineage and may underlie human-specific traits. We generated HARs and chimpanzee accelerated regions with an automated pipeline and an alignment ...
PLANETARY SCIENCE Mars’s moon may be its kin Researchers have long believed that Mars’s two moons, Deimos and Phobos, are captured asteroids. But the first close-up images of Deimos, taken by the United Arab Emirates’s $200 million Hope spacecraft, suggest the 12-kilometer-wide body instead formed from the same material as Mars, researchers revealed this week at the annual meeting of the Europe…
Efficient learning algorithms are implemented in a silicon photonic neural network chip
Police confront protesters who object to Turkey’s handling and storage of earthquake debris.
If our goal is to increase science literacy and trust in science, we may need to reimagine science curriculum
HomeScienceVol. 380, No. 6643ZoonomiaBack To Vol. 380, No. 6643 Full accessIntroduction to Special Issue Share on ZoonomiaSacha VignieriAuthors Info & AffiliationsScience27 Apr 2023Vol 380, Issue 6643pp. 356-357 NEXT ARTICLEGenomics expands the mammalverseNext ContentsInformation & AuthorsMetrics & CitationsView OptionsReferencesMediaTablesShareThe 240 mammals sequenced through the Zoonomia pro…
An analysis of research papers finds differences in article production and recognition for women scientists
Increasingly hot topics in both science and journalism are diversifying the practitioners of these professions and examining what is meant by “objectivity” in this improved world. Bringing wider experiences and perspectives to the laboratory or the ...
Merging supermassive binaries could be revealed through variations in optical and radio emissions
Experts split on whether group comparisons, which could perpetuate discrimination, should be done
Failure of RNA surveillance results in a buildup of defective RNA and promotes melanoma development.
A Review presents a guide to addressing climate change and biodiversity loss as nonindependent crises.
Fully automated system is working 24/7 to create new inorganic materials that could improve batteries, fuel cells, and superconductors
The earthworm is widely distributed, with 4000 species in the world and more than 300 species in China (1, 2), where they are in demand as fishing bait, livestock feed, and components of traditional medicine (3). In recent years, poachers in China have started using soil electrocution to capture earthworms, putting earthworm populations and ecosystems at risk. In February, China prohibited the practice. The decision is a necessary first step to protect agriculture, but to ensure that electric capture ceases, China must follow up with legislation to support the implementation of the ban.
In her Science Insider story “U.S. scientists brace for greater scrutiny of risky research” (3 February, p. 422), J. Kaiser explains that recently issued recommendations (1) from the National Science Advisory Board for Biosecurity (NSABB) would require government oversight for all pathogen research. Although we strongly support the NSABB recommendations, we recognize that the disjointed federal oversight of biosafety and insufficient support could stymie their implementation. To operationalize effective biosecurity oversight systems, the US government must provide regulators and local institutional staff with the appropriate tools and resources.
HomeScienceVol. 380, No. 6642Biological pest control protects pollinatorsBack To Vol. 380, No. 6642 Full accessLetter Share on Biological pest control protects pollinatorsBaoqian Lyu [email protected], Shuchang Wang, [...] , Kris A. G. Wyckhuys, and Zhuo Liu+1 authors fewerAuthors Info & AffiliationsScience20 Apr 2023Vol 380, Issue 6642p. 251DOI: 10.1126/science.adh3467 PREVIOUS ARTICLEThe era of…
Weapons labs say they can overhaul stockpile with simulations and experiments but not tests
Elephant seals sleep 2 hours a day while diving for months at sea, rivaling the record for the least sleep among mammals.
Reinforcement learning enables optimization of overall system properties in protein design.
The collective motion of about 1017 atoms was prepared in quantum superpositions of macroscopically distinct states.
A topological effect was used to confine light to optic fibers for higher information capacity.
Individualism, conspiracism, and partisanship fuel American gun culture, argues a sociologist
The ctenophore nerve net suggests a complex evolutionary history of the animal nervous system
Experiments show ease by which organisms can evolve the ability to harness sunlight for energy
Small trial offers first clinical evidence that a tailored vaccine works and tests of others also look promising
Fossils of Morotopithecus suggest that the more upright stance of hominoids in the Miocene was shaped by dry and open forests.
The predicted rates, functional effects, and selection pressure of postzygotic mutations vary throughout the human life cycle.
The Brazilian unified health system (SUS) was renowned for reducing health inequities (1). However, austerity measures imposed at the end of 2016 (2), a dismantling of the Ministry of Health’s technical capacities (3), and the disastrous COVID-19 pandemic response by the Bolsonaro administration (4) have contributed to a rapid deterioration of health indicators. President Lula da Silva, who was inaugurated last January, faces the daunting task of addressing the setbacks and reconstructing the health sector.
HomeScienceVol. 380, No. 6641Protect oyster reefs in China’s coastal zoneBack To Vol. 380, No. 6641 Full accessLetter Share on Protect oyster reefs in China’s coastal zoneWei Xu, Aifeng Tao [email protected], and Jinhai ZhengAuthors Info & AffiliationsScience13 Apr 2023Vol 380, Issue 6641p. 142 PREVIOUS ARTICLEUnderstanding the menstrual cyclePreviousNEXT ARTICLERestoring health priorities in Bra…
A polemical history shines a scientific spotlight on a remarkable and long-overlooked process
HomeScienceVol. 380, No. 6641PodcastBack To Vol. 380, No. 6641 Full accessBooks et al.Science, Sex, and Gender Share on PodcastScience13 Apr 2023Vol 380, Issue 6641p. 140 PREVIOUS ARTICLEThe perfumer before PasteurPreviousNEXT ARTICLEUnderstanding the menstrual cycleNext ContentsInformation & AuthorsMetrics & CitationsView OptionsReferencesMediaTablesShareRelated Introduction to Special IssueRe…
Reproduction involves a wide range of biological processes, including organ formation and development, neuroendocrine regulation, hormone production, and meiosis and mitosis. Infertility, the failure of reproduction, has become a major issue for human ...
Modern contraception ushered in an era of improved family planning, but more than 60 years after approval of “the pill,” product gaps and unmet needs still exist. Nearly 250 million women worldwide who want to delay or avoid pregnancy do so ineffectively ...
Healthy pregnancies are fundamental to healthy populations, but very few therapies to improve pregnancy outcomes are available. Fundamental concepts—for example, placentation or the mechanisms that control the onset of labor—remain understudied and ...
A combination of data sources from fossil mammal sites pushes back the date of C4 grassland expansion in eastern Africa by over 10 million years.
HomeScienceVol. 380, No. 6641Denmark’s big tent includes postdocsBack To Vol. 380, No. 6641 Full accessLetterOutside the Tower Share on Denmark’s big tent includes postdocsMorten Dall [email protected] and Maria Hauge Pedersen [email protected]Authors Info & AffiliationsScience13 Apr 2023Vol 380, Issue 6641p. 143 PREVIOUS ARTICLERestoring health priorities in BrazilPreviousNEXT ARTICLEIn Science …
HomeScienceVol. 380, No. 6641Past boon, future menaceBack To Vol. 380, No. 6641 Full accessFeature Share on Past boon, future menaceMichael PriceAuthors Info & AffiliationsScience13 Apr 2023Vol 380, Issue 6641p. 127 PREVIOUS ARTICLEMarking timePreviousNEXT ARTICLEDroughts are coming on fasterNext ContentsInformation & AuthorsMetrics & CitationsView OptionsReferencesMediaTablesShareA contemporar…
When Ottoline Leyser was appointed as the chief executive of UK Research and Innovation (UKRI) in 2020, she acquired a front-row seat for some extraordinary events in United Kingdom and European politics. She took charge of UKRI—which was forged from ...
Assisted reproductive technology (ART) refers to processing gametes in vitro and usually involves in vitro fertilization. Originally developed for the treatment of infertility, culture of human embryos in vitro also provides an opportunity to screen ...
Reduced expression of a platelet protein protects against thrombosis during chronic immobilization
More than 500 million years ago, early vertebrates acquired bacterial DNA that made possible their evolution of vision
A review discusses the current perception of brain immunity and its implications for brain aging, diseases, and immune-based therapies.
Antibody genes have GRAB motifs that bind specific amino acids and drive reproducible responses to immunodominant epitopes.
Replacing reactive hydrogens in the monomer improves the properties of a type of polyester in multiple respects.
A newly discovered mode of reproduction in ants results in males being chimeras of haploid cells from two divergent lineages.
As an avian influenza virus devastates the poultry industry, the United States considers an unprecedented step: vaccinating its flocks
An irreverent dive into “medical freedom” highlights the comedy and tragedy of medicine in the United States
HomeScienceVol. 380, No. 6640The future of scientific societiesBack To Vol. 380, No. 6640 Full accessLetterNextGen Voices Share on The future of scientific societiesCamila Fonseca Amorim da Silva [email protected], Edgar Virgüez [email protected], [...] , Sibel Eker, Christina N. Zdenek, [...] , Cathrine Bergh [email protected], Casimiro Gerarduzzi, Yan Ge [email protected], Madeline Klinger, Vee…
When the first cases of human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported from Wuhan, China, in December 2019, there was quick agreement across scientific and health communities that understanding the facts ...
Waveform-controlled electrolysis enables the carbon-carbon coupling of carboxylic acids
Nociceptors control dendritic cell functions through multiple contact-dependent and -independent mechanisms.
Single-cell RNA sequencing identifies the elongating root cortex as the site of brassinosteroid-dependent growth.
Mesoamerican sites offer insights into how communities in the past viewed their own history
HomeScienceVol. 379, No. 6639Protect newborn screening programsBack To Vol. 379, No. 6639 Full accessLetter Share on Protect newborn screening programsKellie Owens [email protected], Carolyn Chapman, and Arthur CaplanAuthors Info & AffiliationsScience30 Mar 2023Vol 379, Issue 6639pp. 1307-1308 PREVIOUS ARTICLEAn ode to Arctic permafrostPreviousNEXT ARTICLEThe science meritocracy myth devalues wom…
As Women’s History Month comes to a close, we shouldn’t overlook the women who contribute so much to science and yet continue to be devalued, ignored, and discouraged from pursuing an academic career. Women researchers are cited less often than men (1) and are substantially less likely than men to be credited with authorship within research teams (2). A variety of factors contribute to gender disparity in science, including harassment (3), conscious and unconscious gender bias (4), and motherhood (5). One often-overlooked obstacle is the myth of meritocracy (6), a set of assumptions that obscures the challenges faced by women and other underrepresented groups.
In their Editorial “Students and postdocs deserve more” (10 February, p. 519), S. M. Malcom and S. Parikh describe elements of academia’s culture and governance that have stirred justified distress and protest among our trainees. I disagree, however, with their conclusion that funding agencies alone can address the problems. Funders indeed have important capacities, including increasing stipends and benefits for students and postdocs, but academic research institutions also hold both power and responsibility to effect change.
Indigenous societies adopted horses of primarily Spanish origin before Europeans arrived in the Great Plains and the American West.
Sweeping new study based on archaeological evidence, chemical isotope analysis, and ancient DNA
Societies generally have reacted to deadly epidemics by strengthening health systems, including laws. Under American federalism (the constitutional division of power between states and the federal government), individual states hold primary public health ...
Cross-disciplinary partnerships are needed to formulate policies that account for developmental vulnerabilities
The rewetting of seasonally dry soils produces large carbon dioxide pulses over Australia.
Passive transfer of antibodies targeting tau reduce tau pathology through the cytosolic antibody receptor and E3 ligase TRIM21.
Fluidic pumps are fabricated in a fiber format and enable highly integrated, wearable soft robotics.
Submillimeter observations show a cold stream of intergalactic gas connecting to a massive galaxy at redshift 3.8.
UK Biobank data reveal 175 gene loci that show nonadditive effects, indicating a role for genetic dominance rather than gene dosage.
Stricter rules could prevent disease outbreaks, but allowances for fur farming spur concern
Discoveries by giant new space telescope JWST are getting too big for theorists to ignore
Regulation of phosphorylation on aquaporin underlies the ability of sorghum to tolerate alkaline soils.
Scanning tunneling microscopy is used to study the vicinity of defects in the Kondo lattice of samarium hexaboride (SmB6).
Oxytocin plays an evolutionarily conserved role for as a regulator of basic empathic behaviors across vertebrates.
Microlattice designs enable rational assembly of 2D films and functional devices into desired 3D curved mesosurfaces.
A bismuth samarium oxide thin film on a substrate maintains its ferroelectricity at a thickness of only 1 nanometer.
A versatile method enables 3D printing of precise silicone structures such as neurovascular and heart valve models.
Solid-state reactions formed vertical carpets of 2D metal carbides and nitrides on metal substrates.
Future adaptation to snow cover depends on standing genetic variation for winter camouflage in white-tailed jackrabbits.
More than 100 U.S. biomedical scientists whose collaborations with China were once encouraged have lost their jobs
We agree with Calow that caution should be exercised when using storylistening in policy advisory systems. The same is true of all forms of evidence. Effective advisory systems that incorporate the natural, physical, and life sciences use mechanisms carefully calibrated to identify, synthesize, authenticate, challenge, and review such evidence. We advocate extending these mechanisms to the humanities and, in the case of storylistening, to the creation and use of narrative evidence.
In their Policy Forum, “‘Storylistening’ in the science policy ecosystem” (13 January, p. 134), C. Craig and S. Dillon explain how the expert evaluation of narratives can facilitate the delivery of humanistic and social science advice for public policy on a range of issues, including those to which scientific advice is also pertinent. Choices about which problems scientists prioritize and which solutions policymakers select are infused with public values (1). Capturing these values can be as challenging as doing the science itself, so any process that makes decision-making more systematic and transparent, as storylistening is supposed to do, is welcome. However, as Craig and Dillon acknowledge, stories often do not tell the truth. In addition, stories do not always reflect universal values. Therefore, caution should be exercised when using the storylistening approach in policy advisory systems.
Communities can leverage institutions of higher education to lure knowledge workers to new regions
Integration of the world’s natural history collections can provide a resource for decision-makers
Optical platforms using material parameters that change with time have diverse applications
Reconstituting a plant biosynthetic pathway enables a sustainable supply of vaccine adjuvants
It wasn’t that long ago when scientific collaboration between the United States and China was enthusiastically encouraged as a means to accomplish the best science. American universities established campuses in China, set up exchange programs for students ...
Virology database cuts off—and then reinstates—scientists who found and analyzed data collected 3 years ago by team in China
Metabolite-induced cysteine carboxyethylation generates neoantigens that may fuel autoimmunity.
A chemical scissor–mediated protocol enables structural and chemical editing of MAX phases and MXenes.
The Kunming-Montreal Global Biodiversity Framework (GBF) includes four goals and 23 targets to halt biodiversity loss and restore natural ecosystems by 2030 (1). The list includes goals to reduce pollution from sources such as plastics and nutrients (Target 7) but overlooks sediment—a key driver of poor water quality that threatens freshwater and marine ecosystems. To conserve aquatic environments, the global community must prioritize explicit indicators and commitments to reduce excess sediment.
In the News story “Research gets a boost in final 2023 spending agreement” (23 December 2022, p. 1263), Science News Staff describe the large increase in the US National Institutes of Health’s (NIH’s) budget for the coming year. They do not mention that, despite the increase, NIH has not raised the annual cap of $500,000 on R01-equivalent budgets in more than 25 years (1). NIH should increase the cap to adjust to modern-day spending power and research cost requirements.
A protein language model enables structure prediction and analysis of more than 600 million metagenomic proteins.
An antisense oligonucleotide approach shows potential for therapeutic restoration of stathmin-2 in TDP-43 proteinopathies.
Conditionally visible coloration in amphibians may be an important step in the evolution of warning coloration.
Limited availability and unwanted effects render the mineral’s future uncertain, despite its agricultural importance
Application expenses are a major challenge for students from low-income backgrounds, this researcher writes
Drug developers are now trying to target ceramides, which appear to contribute to a range of metabolic disorders
The etiology of early-onset colorectal cancer needs to be understood to tackle rising incidence
Structural analysis reveals how the decision to induce apoptotic cell death is regulated
A commensal bacterium exploits phase separation of a transcription termination factor to colonize the gut.
HomeScienceVol. 379, No. 6637Mitigate diseases to protect biodiversityBack To Vol. 379, No. 6637 Full accessLetter Share on Mitigate diseases to protect biodiversityAmadeus Plewnia, Philipp Böning, and Stefan Lötters [email protected]Authors Info & AffiliationsScience16 Mar 2023Vol 379, Issue 6637p. 1098DOI: 10.1126/science.aad2059 PREVIOUS ARTICLEAchieving cognitive libertyPreviousNEXT ARTICLESe…
America’s science, technology, and innovation ecosystem is a powerful engine for progress, but it was conceived in the last century for last century’s goals. Today, the nation’s aspirations have never been bigger: robust health and ample opportunity for ...
A synaptic-resolution map of the neural circuits of a Drosophila larval brain reveals its connection types, neuron types, and circuit motifs.
A high-resolution MINFLUX microscopy approach reveals kinesin steps, substeps, and rotations.
HomeScienceVol. 379, No. 6636Protect Earth’s orbit: Avoid high seas mistakesBack To Vol. 379, No. 6636 Full accessLetter Share on Protect Earth’s orbit: Avoid high seas mistakesImogen E. Napper [email protected]lymouth.ac.uk, Alasdair J. Davies, [...] , Moriba Jah, Kimberley R. Miner, [...] , Richard C. Thompson, Melissa Quinn, and Heather J. Koldewey+4 authors +2 authors fewerAuthors Info & Affi…
Nanoscale conformational dynamics of individual motor proteins are measured in living cells.
Honey bees use social signal learning to improve their ability to waggle dance, a complex example of nonhuman spatial referential communication.
An optical platform is used to realize thermodynamic processes in a negative temperature regime.
A high-throughput platform enables the identification of cell-cell interaction mechanisms in forward genetic screens.
A state-of-the-art experiment over a large dynamic range covers completely different collision mechanisms for NO and ND3.
In his Editorial “ChatGPT is fun, but not an author” (27 January, p. 313), Editor-in-Chief H. H. Thorp describes Science’s position on using artificial intelligence (AI) in scientific papers. The updated policy essentially bans the use of text generated from AI, machine learning, or similar algorithmic tools in articles. However, Thorp overlooks the potential of AI tools to improve equity in science by alleviating linguistic disparities.
Failure to diversify the United States scientific workforce has elicited statements and actions from federal funding agencies that are scrambling to correct inequities. Only last week, a new study showed that Black scientists are underrepresented among ...
A new biography celebrates the contributions of the adventurous and impactful Egyptologist
Science is aware that there may eventually be acceptable uses of ChatGPT and related tools in the preparation of scientific papers. However, we believe it is prudent to wait until we have more clarity on what uses the scientific community will see as permissible.
A mass spectrometry and dialysis method detects metabolite-protein interactions that help to control physiology.
Compassion fatigue will strike most who work with lab animals. But addressing it is challenging
Controversial group’s material could lead to hyperefficient electricity grids and computer chips
Revised regulations require greater disclosure by scientists and more protections for study participants
Swiss biologist Laurent Keller, who is no longer employed by the University of Lausanne, denies all claims
A “creative” strategy to keep crops healthy borrows key pathogen detectors from the animal immune system
Toothed whales evolved a third way of making sounds similar to that of land mammals and birds
Synchrotron radiation-based Mossbauer spectroscopy was used to study valence fluctuations in beta-YbAlB4.
HomeScienceVol. 379, No. 6635Conserving Brazil’s free-flowing riversBack To Vol. 379, No. 6635 Full accessLetter Share on Conserving Brazil’s free-flowing riversStephannie Fernandes [email protected], Thiago B. A. Couto, [...] , Manuel Ferreira, Paulo S. Pompeu, [...] , Simone Athayde, Elizabeth P. Anderson, and Geraldo W. Fernandes+4 authors +2 authors fewerAuthors Info & AffiliationsScience2 Ma…
Small-molecule libraries encoded by peptide tags may accelerate the search for therapeutics
HomeScienceVol. 379, No. 6635Science at Sundance 2023Back To Vol. 379, No. 6635 Full accessBooks et al.Review RoundUp Share on Science at Sundance 2023Vijaysree Venkatraman [email protected], Alison E. Barry [email protected], [...] , Nathaniel J. Dominy [email protected], and Gabrielle Kardon [email protected]+1 authors fewerAuthors Info & AffiliationsScience2 Mar 2023Vol 379, Issue 6635pp. 874-…
After 2 years in Washington, DC, Alondra Nelson is returning to Princeton. A highly decorated sociologist who has written and studied extensively on the intersection of genetics and race, she was appointed by President Joe Biden as deputy director for ...
“The techniques I found useful … resonated with non-ADHD audience members as well,” this postdoc writes
A nasal sound source operates at different vocal registers for biosonar-based prey capture from porpoises to sperm whales.
A 100-million-year simulation of Earth’s surface evolution clarifies the role of sediment transfer and accumulation on a global scale.
Boreal fires in 2021 contributed their largest fraction of global fire carbon dioxide emissions since 2000.
Habitat creation in lakes leads to higher fish abundance than the common practice of simply stocking lakes with fish.
Peptides are used in place of oligonucleotides to tag libraries of small-molecule drug candidates for affinity selection.
Disease-associated mutations in the 3ʹ to 5ʹ RNA exonuclease USB1 affect miRNAs important for hematopoiesis.
Grapevine genetics reveal multiple domestication events, including the concurrent rise of table and wine grape varieties.
Floating offshore wind, which can operate in deep ocean waters, is a potential source for increasing renewable energy production (1). By 2035, 11 to 25% of all new offshore wind projects worldwide will feature floating equipment (2). However, this energy strategy faces technical, economic, and ecological challenges (3). By the end of 2021, only 17 floating offshore wind projects existed globally, with a cumulative installed capacity of only 142.37 MW (4). Countries planning massive investment in floating offshore wind farms, such as China, must ensure that the infrastructure is efficient and environmentally responsible.
Toxic perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been widely used for decades in textiles, food wrappings, flame retardants, water proofing, offshore industry, and cosmetics and are now ubiquitous in the environment (1). PFAS compounds are extremely resistant to biodegradation and persist for millennia, which complicates their management and cleanup (2). Their toxic properties make them carcinogenic, endocrine disruptive, and immunotoxic (3). In February, in response to PFASs’ threat to ecosystems, biodiversity, food security, and drinking water (4, 5), five EU countries proposed a complete phaseout of PFASs (6). Other countries should ban PFAS use as well.
Researchers, health care providers, and patients are exploring ways to mitigate implicit bias
History of mental health treatment can be a disqualifier, interviews with Science reveal
Samples of the carbonaceous asteroid (162173) Ryugu were collected and brought to Earth by the Hayabusa2 spacecraft. We investigated the macromolecular organic matter in Ryugu samples and found that it contains aromatic and aliphatic carbon, ketone, and ...
The Hayabusa2 spacecraft collected samples from the surface of the carbonaceous near-Earth asteroid (162173) Ryugu and brought them to Earth. The samples were expected to contain organic molecules, which record processes that occurred in the early Solar ...
HomeScienceVol. 379, No. 6634An asteroid in the laboratoryBack To Vol. 379, No. 6634 Full accessIntroduction to Special Issue Share on An asteroid in the laboratoryKeith T. Smith https://orcid.org/0000-0002-3683-1661Authors Info & AffiliationsScience23 Feb 2023Vol 379, Issue 6634pp. 782-783 NEXT ARTICLEAnalyzing asteroid RyuguNext Contents Current Issue Samples returned from the aste…
This year marks the 175th anniversary of the American Association for the Advancement of Science (AAAS, the publisher of Science). In striving to advance its mission, the organization’s theme for its annual meeting (2 to 5 March in Washington, DC), “...
A method was developed for metabolite-induced in vivo fabrication of substrate-free organic bioelectronics.
The US White House Office of Science and Technology Policy (OSTP) recently advised federal departments and agencies to promote free, immediate access to data that supports publications of federally funded research (1). However, the guidance did not address federal science journals’ policies regarding access to data and computer code used in peer-reviewed articles. Federal journals should adopt the free, immediate data access policy of OSTP as well as the code access policies of top independent journals.
HomeScienceVol. 379, No. 6634US budget riders compromise conservationBack To Vol. 379, No. 6634 Full accessLetter Share on US budget riders compromise conservationPeter Corkeron [email protected], Kyla Bennett, and Michael J. MooreAuthors Info & AffiliationsScience23 Feb 2023Vol 379, Issue 6634p. 766 PREVIOUS ARTICLEConnect elephant habitats in AsiaPreviousNEXT ARTICLEFederal journals need transp…
HomeScienceVol. 379, No. 6634Connect elephant habitats in AsiaBack To Vol. 379, No. 6634 Full accessLetter Share on Connect elephant habitats in AsiaPriya Davidar [email protected], Reeta Sharma, [...] , Shermin de Silva, Ahimsa Campos-Arceiz, [...] , Benoit Goossens, Jean-Philippe Puyravaud, Bilal Habib, Rahul De, Ee Phin Wong, [...] , Dinesh Neupane, Nurzhafarina Binti Othman, and S. P. Goyal+9…
Many ask authors to disclose use of ChatGPT and other generative artificial intelligence
Analysis of hundreds of mpox patients suggests it is “a different disease” in those with compromised immune systems
CD5 on dendritic cells is immunostimulatory and potentiates tumor-specific T cell responses during immunotherapy.
Overlooked by the oil industry, natural hydrogen could power society for thousands of years
A nickel catalyst produces chiral tertiary alcohols by racemizing ketones before enantioselectively delivering a nucleophile.
As researchers on molecular methods of wastewater analysis (1, 2), we agree with J. I. Levy et al. (“Wastewater surveillance for public health,” Perspectives, 6 January, p. 26) that community-level monitoring can be an efficient way of detecting new outbreaks of disease and activating or prioritizing local public health actions. This approach to monitoring also serves to assess the effectiveness of mitigation and includes communities with minimal individual testing. However, Levy et al. say little about the ethical or legal considerations that must be considered when expanding wastewater surveillance to new targets or communities. Although wastewater monitoring itself is not new, recent pandemic-stimulated growth in monitoring infrastructure and personnel, technological innovations, and proposals for wider application have made the need for ethical review and oversight urgent. Given that interest in and applications of wastewater surveillance continue to grow, the scientific community and government officials have an obligation to use the technology ethically and legally, ensuring that personal data remains private and vulnerable groups are protected (2, 3).
In September, Algeria will change the language used in higher education from French to English (1). If successful, the new policy could facilitate access to English literature and promote international exchange and collaboration. However, Algeria’s plan to implement the change immediately will undermine its benefits.
HomeScienceVol. 379, No. 6633Farming in arid areas depletes China’s waterBack To Vol. 379, No. 6633 Full accessLetter Share on Farming in arid areas depletes China’s waterYongyong Song [email protected], Dongqian Xue, [...] , Beibei Ma, Siyou Xia, and Hao Ye+2 authors fewerAuthors Info & AffiliationsScience16 Feb 2023Vol 379, Issue 6633p. 651DOI: 10.1126/science.adg4780 PREVIOUS ARTICLEScience an…
Patients’ families became research partners in a quest to understand a rare genetic disease
Copyleft AI with Trusted Enforcement (CAITE) can support an adaptable so ft law approach for ethics in AI
Psychedelics act on intracellular serotonin receptors that are not accessible by serotonin alone
The mysteries of the Uranus system can be unlocked through interdisciplinary exploration
In October, the Biden administration released its National Biodefense Strategy (NBS-22), the first update since the COVID-19 pandemic began. Although the document notes that one of the lessons of the pandemic is that threats originating anywhere are ...
The conserved coronavirus fusion peptide is a target of broadly neutralizing antibodies
Scanning tunneling potentiometry was used to probe the nanometer-scale flow of the electron fluid in graphene.
A solution-processed thick dielectric mask with nanoscale openings can maintain both open-circuit voltage and fill factor.
Following in footsteps of National Ignition Facility, companies aim to trigger rapid-fire fusion blasts
Campaign seeks to understand reflective particles in the stratosphere, which cooling schemes would enhance
Scientists find oldest Oldowan butchery tools—long seen as a hallmark of our own genus—with Paranthropus fossils
Understanding moral acceptability and willingness to use is crucial for informing policy
Gate tunable nanoscale negative refraction of polaritons is demonstrated at the interface of 2D materials.
Although technical fixes can help, solutions must focus on broader societal factors at play
HomeScienceVol. 379, No. 6632Soil microplastics pollution in agricultureBack To Vol. 379, No. 6632 Full accessLetter Share on Soil microplastics pollution in agricultureLiuyue He, Zhongbin Li, [...] , Qian Jia, and Zhenci Xu [email protected]+1 authors fewerAuthors Info & AffiliationsScience9 Feb 2023Vol 379, Issue 6632p. 547 PREVIOUS ARTICLEHacking and the social contractPreviousNEXT ARTICLEUnde…
In the 9 December 2022 issue, the Research Article “Competition-level code generation with AlphaCode” (Y. Li et al., p. 1092) and the accompanying Perspective, “AlphaCode and ‘datadriven’ programming” (J. Z. Kolter, p. 1056) describe an artificial intelligence (AI)–based system for generating code. The authors explain that the system can be used for small coding problems, such as tests for computing students, and that they are far from being useful in computing applications that include millions of lines of code, such as word processing. As we enter an era of AI where tools like AlphaCode and chatGPT will change how tasks are performed, it is important to understand the boundaries of what they can and cannot do.
In his Science Insider piece “New biodiversity pact sets ambitious goals, but will nations deliver?” (22 December 2022, https://scim.ag/1jG). E. Stokstad explains that the Kunming-Montréal Global Biodiversity Framework (GBF) of the Convention on Biological Diversity (CBD) is scientifically strong but legally weak. The GBF lacks hallmarks of effective international agreements, such as reciprocal responsibilities, dispute resolution systems, uncompromisable goals, and noncompliance penalties. For the GBF to be effective, these shortfalls must be addressed.
Giant tanks full of Atlantic salmon could help meet rising demand while lowering environmental impact
A slow-motion crisis is underway among graduate students and postdocs in the United States who comprise today’s indispensable research and teaching workforce and tomorrow’s scientific leaders. Low pay, lack of benefits, and sometimes toxic research ...
Ultrafast nonlinear spectroscopy can unravel the dynamics of highly excited electronic states
Ancient Oldowan sites from Nyayanga show evidence of hippo butchery, plant processing, and the first Paranthropus, a type of extinct hominin, from southwest Kenya.
The Guiyang Biota fossil assemblage reveals the rapid rise of a modern-type marine ecosystem after the Permian-Triassic mass extinction.
Nanoscale negative refraction is demonstrated for polaritons propagating normal to the interface of 2D bicrystals.
Whole-genome analyses place Elopomorpha (tarpons, eels) and Osteoglossomorpha (bony-tongues) in the sister group to all other ray-finned fish.
Sometimes acrimonious debate is playing out in scientific papers, at conferences, and on social media
Artificial intelligence–powered scans capture large leaks from space nearly in real time
A drug developed to quell urinary tract infections also appears to be a promising treatment for Balamuthia mandrillaris
Computer-aided retrosynthesis supplemented by graph-based step prioritization minimized step count in an alkaloid synthesis.
Feedback projections in the primate visual system convey attention-related modulation of neuronal firing activity.
An N-heterocyclic carbene acts as a single carbon atom donor in converting α,β-unsaturated amides into homologated lactams.
Stretchable films of liquid metal are used to protect flexible devices from liquid and gas permeation.
The COVID-19 pandemic has highlighted important considerations for modeling future pandemics
Stable carbenes deliver a carbon atom to simple amides, producing a range of cyclic compounds
HomeScienceVol. 379, No. 6631Protect seagrass meadows in China’s watersBack To Vol. 379, No. 6631 Full accessLetter Share on Protect seagrass meadows in China’s watersJianguo Du, Bin Chen, [...] , Ivan Nagelkerken, Shiquan Chen, and Wenjia Hu [email protected]+2 authors fewerAuthors Info & AffiliationsScience2 Feb 2023Vol 379, Issue 6631p. 447DOI: 10.1126/science.adg2926 PREVIOUS ARTICLESeller’s …
Between 2010 and 2020, China increased its forest area by 193,680 km2 (1). The country plans to plant 70 billion more trees before 2030 (2). Although the UN’s Global Forest Goals regard the increase of forest cover as a primary goal (3), the types of trees and locations selected for planting can determine whether increased cover constitutes a conservation success or an environmental threat.
Luiz Iná cio Lula da Silva started his third term as president of Brazil in January. In his November 2022 speech at the United Nations Climate Change Conference (COP27), Lula committed to halt deforestation, stop illegal mining and other environmentally damaging activities, and make the country a global leader in addressing climate change (1). He has also declared that Brazil’s path to becoming a developed and self-sufficient country depends on science, technology, and innovation (1, 2). His position on these matters has already unlocked international investments for the country, which will likely increase (3). To make good on his promises, Lula should invest in Brazil’s early-career scientists.
Scientists discover the chemicals applied to corpses in a 2700-year-old mummification workshop
Expert panel recommends stricter reviews of research involving pathogens or toxins that could have “dual use”
The ranking of universities and colleges at the national and global level is a well-known dubious practice. Flawed methodologies generate distorted and inaccurate profiles of these institutions. Yet, rankings have remained a popular and trusted measure of ...
FDA panel will discuss switch to an annual booster in the fall, akin to flu vaccination strategy
Lymphoma BTG1 mutations reveal a tumorigenesis mechanism that recapitulates developmental super-competition processes.
The history of science is littered with violations of the human rights of research participants (1, 2). One response has been regulation. In the United States, the Belmont Report lays out ethical principles for human subjects research (3), which form the foundation of modern-day institutional review boards. According to the Belmont Report, ethics committees and investigators need to determine whether the benefits of the research outweigh the costs and whether the costs unevenly burden particular groups. However, the assumptions underlying such assessments can be flawed (4, 5). Without evidence about the causal effects of social science research on participant welfare, researchers risk causing unexpected harms or missing unexpected benefits.
A superconducting qubit-metamaterial system creates a scalable lattice quantum simulator.
Atmospheric chemistry and composition underlie the existential threats of climate change and ozone depletion (1), and poor air quality represents the greatest environmental health issue in the modern world (2). However, the only targets and indicators related to atmospheric health and clean air in the United Nations Sustainable Development Goals (SDGs) focus on reducing fine particulate pollution levels and the associated mortality rates (3, 4). By creating targets for a broad range of specific pollutants, the SDGs could facilitate more effective actions, monitoring, and funding.
HomeScienceVol. 379, No. 6629Avian flu threatens Neotropical birdsBack To Vol. 379, No. 6629 Full accessLetter Share on Avian flu threatens Neotropical birdsVíctor Gamarra-Toledo [email protected], Pablo I. Plaza, [...] , Roberto Gutiérrez, Paola Luyo, [...] , Lizbeth Hernani, Fernando Angulo, and Sergio A. Lambertucci+4 authors +2 authors fewerAuthors Info & AffiliationsScience19 Jan 2023Vol 379…
An anthropologist argues that experimental communities in Madagascar influenced the European Enlightenment
Under pressure to reinvent itself, the CAS should concentrate on managing large-scale research infrastructures
Pathogenic variants related to mitosis and telomere integrity are enriched in sarcoma patients
Chain-condensation reactions in a chain silicate precursor form Si–O–Si bridges and an extra-large pore, low-density zeolite.
Llama nanobodies help identify the receptor complex that controls nodule organogenesis in plant symbiosis with nitrogen-fixing bacteria.
In fluctuating environments, phenotypic mismatching may reflect an error-avoidance bias that enhances a mother squirrel’s overall lifetime fitness.
Observations of the night sky by citizen scientists show that it is rapidly getting brighter due to light pollution.
Strain relief of adjacent double bonds in a carbon ring enables a key cycloaddition in the synthesis of a marine natural product.
Human genome germline sequencing reveals that defects in centrosome and shelterin pathways may specifically increase risk for sarcomas.
Data from citizen scientists reveal a worrying growth in light pollution over the past decade
Next month, a judge in Sydney will hear new expert testimony in a criminal case that has fascinated Australia for 2 decades: that of Kathleen Folbigg, who in 2003 was convicted of the murder of three of her infant children and manslaughter in the death of the fourth.
In the context of climate policy, “loss and damage” refers to unavoided climate change impacts, including those from extreme weather events and slow-onset events such as sea-level rise, increasing temperatures, and loss of biodiversity. Some argue that ...
Statistician Richard Gill has helped exonerate nurses accused of killing multiple patients
Proposed changes to peer review seek to minimize influence of applicant’s resume and workplace
For the first time, scientists observed a worm’s cell-by-cell transition from larva to adulthood
Many aid groups have suspended their work as United Nations is negotiating to reverse the decree
But the agency will update its gender identity question in a massive demographic survey
Manipulation of gut microbiota attenuates brain atrophy in a genetically engineered mouse model of tau-mediated neurodegeneration.
Parasitic ticks exploit host-derived interferon-γ through cross-species signaling to promote arthropod immunity and development.
Iran’s climate varies from arid to semiarid, but the country’s use of groundwater is three times higher than the global average (1). In the past few decades, groundwater extraction through pumping has caused irreparable damage to Iran’s plains (2). The groundwater supply, which is decreasing by 6 billion cubic meters annually, is the source of about 55% of Iran’s water consumption (3). Iran must take steps to protect the quality and quantity of its groundwater.
Next month will mark 1 year since Russia escalated its war on Ukraine. The senseless casualties and destruction have been met with stunning resilience by Ukraine and international opposition to Russia. Although the war continues, there is hope that ...
Ionic computing raises the possibility of devices that operate similarly to the human brain
A journalist’s empathetic portrait of COVID-19 “long haulers” sheds light on the realities of postviral illness
Parks, beaches, squares, and streets are vital sites for individuals, communities, and society to flourish
HomeScienceVol. 379, No. 6628Seed banks needed to restore ecosystemsBack To Vol. 379, No. 6628 Full accessLetter Share on Seed banks needed to restore ecosystemsUromi Manage Goodale, Alexandre Antonelli, [...] , Cara R. Nelson, and Marian M. Chau [email protected]+1 authors fewerAuthors Info & AffiliationsScience12 Jan 2023Vol 379, Issue 6628p. 147 PREVIOUS ARTICLEIn defense of public spacePrevio…
On 3 October 2022, the US Supreme Court heard arguments in Sackett v. USEPA, the latest in a series of cases seeking to clarify which waters are protected under the US Clean Water Act (1). Concurrently, the US Environmental Protection Agency (EPA) and the US Army Corps of Engineers are actively drafting rules for the third time in the past 10 years, after the Obama-era Clean Water Rule (2) was repealed (3) and the Trump-era Navigable Waters Protection Rule (4) was vacated and remanded (5). Consequently, enforcement of the Clean Water Act has reverted to 1986 agency guidance (6). Although scientific understanding of the physical, chemical, and biological connectivity of waters (7) and the ability to leverage geospatial data to guide jurisdictional determinations (8, 9) have grown substantially since 1986, the Clean Water Act enforcement and rulemaking have yet to catch up.
A polyelectrolyte-confined aqueous ionic memristor demonstrated a range of neuromorphic functions with high energy efficiency.
Two nanofluidic devices can reproduce Hebbian learning using ions in water as charge carriers, similar to how neurons work.
A different processing strategy creates a high-strength steel with good ductility without expensive elements.
Formamidinium–based lead iodide perovskite films can be stabilized by growing films with a greater fraction of (111) facets.
Removing oxidative activation sites in CaMKIIδ by base editing sustains heart function after ischemia-reperfusion injury.
FBP2 loss in hummingbirds coincided with the evolution of true hovering flight and likely contributed to muscle adaptations.
Stereodynamic effects in the fundamental chemical H + HD reaction are demonstrated with the most detailed resolution.
Silt overload and mercury pollution endanger river ecosystems—and the people who depend on them
Agency warns about brain swelling and bleeding on drug’s label, but imposes few restrictions on lecanemab’s use
A review discusses the science and technology of lithium niobate and its role in various aspects of photonics.
Elucidation of maize strigolactone biosynthetic pathway has the potential for controlling the parasitic witchweed Striga.
Thermal imaging can detect pore formation during laser powder bed fusion, helping to ensure quality control.
A fourth meningeal layer acts as a barrier that divides the subarachnoid space into two distinct compartments.
Applying oscillatory force on cilia in zebrafish embryos reveals that they are mechanosensors shaping cardiac left-right asymmetry.
A history of obesity stably alters chromatin in macrophages and promotes inflammatory disease.
Wave physics predicts a minimum size for optical components dependent on their function.
A philosopher prioritizes agency and Anthropocene concerns in a theory of animal justice
HomeScienceVol. 379, No. 6627The fruits of failureBack To Vol. 379, No. 6627 Full accessLetterNextGen Voices Share on The fruits of failureGarima Singh [email protected], Ning Zhang [email protected], [...] , Camila Fonseca Amorim da Silva [email protected], Divyansh Agarwal, [...] , Salam Salloum-Asfar, Stephanie Mohammed [email protected], Ashley Barbara Heim [email protected], Wagner Eduardo R…
The new year 2023 arrives with promising developments in fusion research. In December, scientists at the US National Ignition Facility (NIF) focused 2.05 megajoules of laser light onto a capsule of fusion fuel and produced 3.15 megajoules of energy. This ...
“I am forever being reminded, in ways big and small, that many think I don’t belong,” this postdoc writes
Largest hydroelectric project in the Amazon has shrunk fish populations and threatened native communities
Left-right symmetry is broken when immotile cilia sense the direction of fluid flow in mouse embryos.
High-caliber scientists who return to China from training abroad outperform peers who remain overseas in regard to publications and access to funding.
Making COVID-19 manageable and covering financial losses from climate change could make headlines
Scientists are field testing simpler, faster, cheaper methods to sample animals for dangerous pathogens
Official death tolls are impossibly low, and some worry new variants may escape detection
Metalated ylides react with carbon monoxide by phosphine displacement to form stable precursors to ketenes and related compounds.
Rapid crystallization with gas-quenching maintains bromide-iodide mixing for wide-bandgap perovskite films for tandem cells.
Simultaneous measurements of two nitrogen vacancy centers in diamond enables spatiotemporal magnetometry.
Glass frogs actively maintain transparency by removing red blood cells from the circulation and concealing them in their livers.
High-entropy design can lead to orders of magnitude increases in ionic conductivity regardless of the crystal framework.
The circuit specificity of motor cortex neurons in suppressing sensory versus emotional-aversive dimensions of neuropathic pain is shown.
Femtosecond light sheets can be used to assemble a wide range of materials into very small three-dimensional structures.
Melting a solvent with a salt and then desalinating it enables a reversible cooling cycle
HomeScienceVol. 378, No. 6626Accessing the Loss and Damage climate fundBack To Vol. 378, No. 6626 Full accessLetter Share on Accessing the Loss and Damage climate fundBharat Dahiya [email protected]th and Mahesti OkitasariAuthors Info & AffiliationsScience22 Dec 2022Vol 378, Issue 6626p. 1285DOI: 10.1126/science.adf9670 PREVIOUS ARTICLEMaking modern medicinesPreviousNEXT ARTICLERemote opportuniti…
The business side of drug development comes to the fore in a tale of two blockbuster blood cancer therapeutics
HomeScienceVol. 378, No. 6626Remote opportunities for scholars in UkraineBack To Vol. 378, No. 6626 Full accessLetter Share on Remote opportunities for scholars in UkraineKarishma Chhugani, Alina Frolova, [...] , Yuriy Salyha, Andrada Fiscutean, [...] , Oksana Zlenko, Sanita Reinsone, Walter W. Wolfsberger, Oleksandra V. Ivashchenko, Megi Maci, [...] , Dmytro Dziuba, Andrii Parkhomenko, Eric Bort…
Innovative treatment designed to treat mitochondrial disease shows promise in a few patients
Budgets of many civilian science agencies will grow, but not always by as much as White House had requested
Study of famed meteorite by quantum diamond microscope also reveals flips in martian field
Shifts in research culture, incentives, and technology would be needed for wide adoption
Alkaline lime powder spread in Florida estuary drew down carbon and reduced acidification
Synthetic circuits that deliver IL-2 locally to tumors allow CAR-T cells to overcome suppressive tumor microenvironments.
A tyrosine/glycine–rich YG domain of PEX13 forms a meshwork in the peroxisomal membrane through whic–h proteins are imported.
Cell-wide organellar rewiring through endosomal lipid signaling enables cells to adapt to altering nutrient supplies.
Photoexcitation promotes palladium-catalyzed C–N bond formation between internal alkenes and aliphatic amines.
ATG9A promotes the LC3-independent lysosomal detoxification of the cytotoxic complex IIa to prevent TNF-induced apoptosis.
A well-designed zeolite-filled mixed matrix membrane outperforms zeolite-only membranes in gas separation.
In the past 2 years, the European Union and the United States announced plans to spend $573 and $391 billion, respectively, through 2030 on climate actions (1) and passed landmark legislation such as the US Inflation Reduction Act (2). Although unprecedented in size and scope, these combined investments of $964 billion pale in comparison to the more than $4 trillion in global clean energy investment needed annually by 2030 to stay on track for net zero greenhouse gas emissions by 2050 (3). To maximize the impact of this public money, efficient policies informed by independent, objective analysis will be needed. Yet scientists who commit to policy-relevant research face unique challenges that must be addressed.
The eruption of Mauna Loa could disrupt data collection that has taken place daily for decades.
HomeScienceVol. 378, No. 6625Best books of 2022Back To Vol. 378, No. 6625 Full accessBooks et al.Podcast Share on Best books of 2022Science15 Dec 2022Vol 378, Issue 6625p. 1179DOI: 10.1126/science.adg0504 PREVIOUS ARTICLEThe model, the modeler, and the truthPreviousNEXT ARTICLEGive long-term datasets World Heritage statusNext Contents Current Issue Synthetic cytokine circuits that d…
Escaping the realm of simplified systems is difficult but necessary, argues a statistician
An ethicist offers a framework for incorporating ethical and legal constraints into autonomous and AI weapons
HomeScienceVol. 378, No. 6625Runners-upBack To Vol. 378, No. 6625 Full accessSpecial Issue News Share on Runners-upElizabeth Pennisi, Erik Stokstad, [...] , Ann Gibbons, Richard Stone, [...] , Jon Cohen, Zack Savitsky, Paul Voosen, Matthew Hutson, and Jocelyn Kaiser+6 authors +4 authors fewerAuthors Info & AffiliationsScience15 Dec 2022Vol 378, Issue 6625pp. 1162-1167DOI: 10.1126/science.adg2799 …
In a speech at Rice University in September 1962, US President John F. Kennedy announced plans for human spaceflight to the Moon by saying, “We choose to go to the Moon in this decade and do the other things, not because they are easy, but because they ...
JWST makes a spectacular debut, AI gets creative, giant bacteria surprise, and the year’s other big advances in science
Research team identifies chemicals from bacteria that create a brain reward signal when mice run
COVAX delivered more than 1.8 billion doses, but many arrived too late to have much impact
This week, Montreal, Canada, is at the epicenter of international negotiations for biodiversity. Thousands of people from around the world are attending the 15th Conference of the Parties to the United Nations Convention on Biological Diversity (COP15) to ...
Combinations of signaling motifs and machine learning can guide engineering of receptors with the desired phenotypes.
Scientist who oversees famed extinction-day site denies claims he made up data to scoop a former collaborator
Results from a phase 1 clinical trial for a broadly neutralizing antibody germline-targeting HIV vaccine in humans are reported.
An intercellular genetic technology monitors cell-cell contact and traces cell contact histories by permanently marking contact between cells.
A review explains that Madagascar’s biodiversity is the product of complex processes that produced remarkable life-forms, many remaining undocumented.
A superconducting-based circuit allows the coherent control of topological states of quantized light.
Cellular energy status regulates the physiology of nitrogen-fixing nodules in soybeans.
Active DNA demethylation contributes to enhancer activation, lineage specification, and neurotoxicity during chemotherapy.
Reinforcement learning achieves human expert–level performance in the large-scale imperfect information board game Stratego.
Last month in Egypt at the United Nations Climate Change Conference, Brazil’s president-elect Luiz Inácio Lula da Silva reaffirmed his pledge to make Brazil a global leader in addressing climate change and deforestation. However, when Lula takes the reins ...
Active DNA demethylation maintains enhancer activity in nonproliferating cells but can damage DNA
Clinical trial shows that an HIV vaccine can elicit rare antibodies, but there is more to do
HomeScienceVol. 378, No. 6623Guizhou snub-nosed monkey in perilBack To Vol. 378, No. 6623 Full accessLetter Share on Guizhou snub-nosed monkey in perilTao Ju and Xianghong Dong [email protected]Authors Info & AffiliationsScience1 Dec 2022Vol 378, Issue 6623p. 956DOI: 10.1126/science.adf3707 PREVIOUS ARTICLEMeet the HuxleysPreviousNEXT ARTICLECombatting national research restrictionsNext Conten…
In her Science Insider piece “Indonesia bans five foreign scientists, shelves conservation data” (7 October, https://scim.ag/up), D. Rochmyaningsih describes how the Indonesian government is suppressing conservation scientists, research, and data in pursuit of economic development. Other governments have also restricted domestic and international research on politically sensitive topics, sometimes indirectly by controlling data (1), restricting funding (2), denying access to research sites (3) or specimens (4, 5), or labelling researchers as disruptive protesters, foreign spies, or provocateurs (6–8). To address global environmental challenges, researchers need freedom to collect, analyze, and share data without political constraints. International treaties and organizations could counteract some of these restrictions.
Over the past few decades, China’s coastal zone has been subject to extensive land reclamation. As of 2014, approximately 65% of all coastlines in China were affected by the expansion of farmlands, salt pans, aquaculture ponds, roads, and buildings (1), resulting in disrupted ecosystem services, ecological security, and sustainability (2–4). About a decade ago, the Chinese government began addressing the problem (2, 5). On 1 June, a new Wetland Protection Law came into effect, which is expected to build on past success (6). However, invasive species now threaten China’s coastal wetlands.
Ancient DNA from German cemetery suggests timing of population bottleneck for today’s largest Jewish group
Science investigation reveals significant drop in U.S. programs requiring GRE scores from applicants
The application of synthetic biology approaches to study development opens the possibility to build and manipulate developmental processes to understand them better. Researchers have reconstituted fundamental developmental processes, such as cell ...
HomeScienceVol. 378, No. 6622Cell engineeringBack To Vol. 378, No. 6622 Full accessIntroduction to Special Issue Share on Cell engineeringL. Bryan Ray and Priscilla N. KellyAuthors Info & AffiliationsScience24 Nov 2022Vol 378, Issue 6622pp. 846-847DOI: 10.1126/science.adf8627 NEXT ARTICLEThe emerging era of cell engineering: Harnessing the modularity of cells to program complex biological functio…
Collective sensing and phenotypic diversification aid response to environmental fluctuations
Any scientist working with animals is familiar with the “3Rs”—replacement, reduction, and refinement (1). Replacement refers to using alternative methods instead of live animals. Reduction requires using the minimum number of animals. Refinement demands the optimization of experimental techniques, housing, and care to safeguard animal welfare. The 3Rs led to a paradigm shift in guiding the use of animals in research, through legislation or institutional review committees worldwide. The model could be similarly effective if applied to farm animal production.
To promote a circular economy and mitigate pollution, the bioplastics industry has begun to phase out polymers derived from petrochemicals (1–3). This action is a positive step, but it doesn’t affect the many bioplastics on the market, which also contain potentially harmful additives. Given that bioplastics will likely replace polymers, it is crucial to determine which bioplastics cause the least harm.
HomeScienceVol. 378, No. 6622Global plastic treaty should address chemicalsBack To Vol. 378, No. 6622 Full accessLetter Share on Global plastic treaty should address chemicalsTridibesh Dey [email protected], Leonardo Trasande, [...] , Rebecca Altman, Zhanyun Wang, [...] , Anja Krieger, Melanie Bergmann, Deonie Allen, Steve Allen, Tony R. Walker, [...] , Martin Wagner, Kristian Syberg, Susanne M. …
A writer probes humanity’s often fraught and paradoxical relationships with other creatures
A historian explores the remarkable early civilizations of the Near East, from Uruk to Babylon
Assessing multiple site conditions and climate reveals the impacts of livestock pressure
Optimizing carrier mobility with composition and processing is key for thermoelectric coolers
A simple sugar mixture transfers functional components to surfaces with intricate geometry
The world needs more physicians. Increasing their numbers alone won’t solve the many problems associated with improving health care. But it doesn’t help to have a dearth of doctors, who were generally in short supply before COVID-19 struck. The pandemic ...
Immune cells are being engineered to recognize and respond to disease states, acting as a “living drug” when transferred into patients. Therapies based on engineered immune cells are now a clinical reality, with multiple engineered T cell therapies ...
With increasing evidence that microbes colonize tumors, synthetic biology tools are being leveraged to repurpose bacteria as tumor-specific delivery systems. These engineered systems can modulate the tumor microenvironment using a combination of their ...
A new era of biological engineering is emerging in which living cells are used as building blocks to address therapeutic challenges. These efforts are distinct from traditional molecular engineering—their focus is not on optimizing individual genes and ...
Meta’s algorithm tackles both language and strategy in a classic board game that involves negotiation
Once a medical student there, a Science reporter returns to find notable gains—and big challenges
Agency mulls end for Terra, Aqua, and Aura satellites, but researchers lobby for an extension
Researchers say there is a growing body of evidence these viruses interfere with each other’s spread
India should consider climate change and air pollution impacts as it plans its future electricity infrastructure.
A review highlights the discovery of fast radio bursts and the subsequent rapid advances in understanding them.
The IUCN Red List index tracks the recovery of tunas and billfishes as the status of undermanaged sharks continues to decline.
The Mediator kinase module regulates T cell effector function, and its genetic or chemical inhibition enhances T cell potency.
The Intergovernmental Panel on Climate Change (IPCC) predicts that 70 to 90% of warm-water reefs will disappear this century even if warming is constrained to 1.5°C (1). But the corals of the northern Red Sea are thermally resilient and likely to survive IPCC warming projections (2, 3). Egypt’s territorial waters contain about 1800 km of fringing reef (4) and include almost the entire western half of the resilient region in the northern Red Sea. Although Egypt’s corals can tolerate the rising temperatures that are decimating reefs elsewhere, they face severe local threats, including unsustainable tourism, coastal development, sewage discharge, and desalination plant discharge (5). Interventions are urgently needed to improve coral conservation.
Universities are one of the oldest human institutions, enduring with essentially the same blueprint for a thousand years. Before the current COVID-19 pandemic, there was much talk about the promise of massive open online courses, distance learning, and ...
Incorporated inside and outside buildings—even in windows—new panels could help expand green energy potential
Iran’s fundamentalist government has long feared students and academics, because independent thinking and inquiry are at odds with the extreme rhetoric of a repressive religious regime that discourages questioning or testing—especially when those asking ...
Electricity sector policies should be designed not only to mitigate carbon emissions but also to reduce inequities
Good intentions at the intersection of principles, policy, and profit make for a bumpy road
HomeScienceVol. 378, No. 6620Extinction risk for Australia’s iconic gliderBack To Vol. 378, No. 6620 Full accessLetter Share on Extinction risk for Australia’s iconic gliderKita Ashman [email protected]f.org.au and Michelle WardAuthors Info & AffiliationsScience10 Nov 2022Vol 378, Issue 6620p. 608DOI: 10.1126/science.adf1013 PREVIOUS ARTICLEGenetic engineering’s contested ethicsPreviousNEXT ARTIC…
China leads global renewables installation (1, 2). In 2021, China’s solar and wind installed capacity was 306.4 GW and 329 GW, respectively, accounting for 36.3% and 39.9% of the global market (3). However, enthusiasm for installed capacity obscures insufficient penetration into some areas of the country, which hinders the potential benefits of wind and solar energy. In 2021, the waste rates of China’s wind and solar were 3.1% and 2.0%, respectively, and more than 10% in Qinghai Province (4).
Group II intron ribonucleoproteins are retroelements that can recognize the shape and sequence of their structured DNA target.
Absorption lines in nearby stars set a limit of 50 parts per billion on variations of the fine structure constant.
Former Caltech astronomer Christian Ott filed a criminal complaint against two Finnish academics after a new job offer was withdrawn
PR23 variety doesn’t need to be replanted every year, but might create problems with pests, diseases, and weeds
Assumptions about how weather, climate, and glacial ice conspired to preserve 5100-year-old Ötzi were wrong, researchers argue
The molecular basis of astrocyte diversity and of their complex morphology in health and disease states is elucidated.
A new suite of voltage sensors enables simultaneous cellular-resolution neuronal activity imaging in awake mice and flies.
There is more to brain connections than the mere transfer of signals between brain regions. Behavior and cognition emerge through cortical area interaction. This requires integration between local and distant areas orchestrated by densely connected ...
A comprehensive description of how neurons and entire brain regions are interconnected is fundamental for a mechanistic understanding of brain function and dysfunction. Neuroimaging has shaped the way to approaching the human brain’s connectivity on the ...
Can we construct a model of brain function that enables an understanding of whole-brain circuit mechanisms underlying neurological disease and use it to predict the outcome of therapeutic interventions? How are pathologies in neurological disease, some of ...
Detailed knowledge about the neural connections among regions of the brain is key for advancing our understanding of normal brain function and changes that occur with aging and disease. Researchers use a range of experimental techniques to map connections ...
HomeScienceVol. 378, No. 6619No neuron is an islandBack To Vol. 378, No. 6619 Full accessIntroduction to Special Issue Share on No neuron is an islandPeter SternScience3 Nov 2022Vol 378, Issue 6619pp. 486-487DOI: 10.1126/science.adf4275 NEXT ARTICLEAtlas-based data integration for mapping the connections and architecture of the brainNext Contents Current Issue Dual-polarity voltage …
In June, the largest flooding disaster of this century hit Pakistan, flooding farmland and inducing a severe food crisis (1). Over 30 million people were affected, and more than 1000 people were killed (2). Developing countries such as Pakistan remain at high risk of disasters arising from climate change. To mitigate the damage, countries facing such threats should cooperate to improve disaster prediction capability and infrastructure.
Forests comprise less than 5% of Pakistan’s total area (1), and every year more forest area is destroyed by anthropogenic and natural activities. Pakistan’s dwindling forest cover has exacerbated the effects of climate change (2). In June, the country suffered devastating floods that threatened valuable ecosystem resources, including agricultural products, as well as the socioeconomic conditions of millions of people (3). Given the ability of vegetation, native biodiversity, and connected waterways and floodplains to serve as buffers for storms, rains, and floods (4, 5) and mitigate climate change (6), Pakistan and other Asian countries must increase their environmental budgets to prioritize ecosystem restoration.
HomeScienceVol. 378, No. 6619Pakistan’s floods flow from climate injusticeBack To Vol. 378, No. 6619 Full accessLetter Share on Pakistan’s floods flow from climate injusticeMuhammad Ahmed Waqas [email protected]Science3 Nov 2022Vol 378, Issue 6619p. 482DOI: 10.1126/science.ade8490 PREVIOUS ARTICLEReifying racism in medicinePreviousNEXT ARTICLERestore Pakistan’s forests to prevent floodsNext Co…
False beliefs about racial differences have a long history in physician training programs
Bigger wildfires in the Siberian Arctic signal release of more carbon to the atmosphere
Efforts to innovate our way to better health consistently fail to deliver on equity promises
In the 30 years since the world began negotiating the reduction of greenhouse gas (GHG) emissions, no one has identified exactly where all that pollution is coming from. That will begin to change next week when Climate TRACE (Tracking Real-Time ...
Analysis opens new avenues for studying diseases of the past, will raise standards of working with racially sensitive collections, experts say
Current methods to extract key ingredients for green technologies require polluting chemicals
But Bolsonaro’s successor will be hampered by a faltering economy, a hostile Congress, and a deeply divided population
Functional screening of commensal gut microbiota reveals small-molecule genotoxins in patients with inflammatory bowel disease.
Progress flipping the handedness of a key enzyme in protein building may pave the way for mirror-image life
The eight countries that border the Persian (or Arabian) Gulf, a critical marine ecosystem with the warmest water on Earth (1), share in the economic benefits produced by its fisheries. However, current harvest control rules for fisheries in the region are neither sufficiently strict nor sufficiently consistent across countries to protect Persian Gulf ecosystems, especially in the face of climate change. Rising temperatures affect the structure and function of marine food webs, exacerbating the vulnerabilities of marine species and the fisheries sector, as well as the challenges in accurately tracking ecosystem health. To prevent long-term harm to the Persian Gulf’s ecosystems, fisheries management in the region must balance economic and environmental priorities.
Swedens legacy as a global leader in the push to put climate and the environment at the heart of government decision-making may have come to an end on 18 October 2022. The first casualty of the countrys new right-wing government was the Ministry of the ...
Iterating machine learning with robotic experimentation uncovered higher-yielding conditions for a common coupling reaction.
Short bursts of innovation have punctuated a long-term decline in the rate of placental mammal skull evolution over the past 66 million years.
HomeScienceVol. 378, No. 6618Vote against Amazon deforestation in BrazilBack To Vol. 378, No. 6618 Full accessLetter Share on Vote against Amazon deforestation in BrazilCássio Cardoso Pereira [email protected]Science27 Oct 2022Vol 378, Issue 6618pp. 364-365DOI: 10.1126/science.adf2475 PREVIOUS ARTICLESweden threatens European biodiversityPreviousNEXT ARTICLEOverfishing and warming put Persian Gul…
Instead, eLife will offer to peer review selected submissions for $2000 fee, then make paper and critiques free to read
After gaining the trust of “jackpot” shows and county and state fairs, a research team is assessing how big a risk infected show pigs pose to people
A pair of authors set out to humanize the enigmatic pharaoh 100 years after his tomb’s discovery
In June, the European Commission proposed a nature restoration law to repair Europe’s damaged ecosystems (1). This regulation stands out by setting legally binding biodiversity targets for member states and has been well received by ecological scientists (2). However, the proposal faces an uphill battle to become European law. In January 2023, the rotating presidency of the European Union will be held by Sweden, whose parliament has already voted against the Commission proposal, arguing that its conservation measures were disproportionate (3). The newly appointed Swedish government terminated on its first day the 35-year-old standalone Ministry of Environment in charge of nature conservation (4). Given its political record of weakening biodiversity laws, Sweden is also likely to counter the proposed European law during its presidency.
HomeScienceVol. 378, No. 6618Eating to Extinction: The World’s Rarest Foods and Why We Need to Save ThemBack To Vol. 378, No. 6618 Full accessBooks et al.Podcast Share on Eating to Extinction: The World’s Rarest Foods and Why We Need to Save ThemScience27 Oct 2022Vol 378, Issue 6618p. 363DOI: 10.1126/science.adf1091 PREVIOUS ARTICLEWhat does a professor look like?PreviousNEXT ARTICLESweden threat…
A coherent interface design makes brittle silicon nitride ceramics deformable mediated by a stress-induced phase transformation.
A small-molecule compound may help in the development of rapidly acting antidepressants by regulating the firing of serotonergic neurons.
Photocatalysis can efficiently and selectively modify the configuration of conventionally inert carbon–hydrogen bonds.
A mycobacterial phosphatase binds ubiquitin to alter host membrane phospholipids to subvert gasdermin D–mediated cell death.
An open-state structure reveals how cold sensing channels can be activated by chemicals.
A monolayer heterostructure rectifier was developed to obtain simultaneous electrical and thermal rectification.
HomeScienceVol. 378, No. 6616Lessons from extinctions of dugong populationsBack To Vol. 378, No. 6616 Full accessLetter Share on Lessons from extinctions of dugong populationsMingli Lin, Samuel T. Turvey, Mingming Liu, Heidi Ma, and Songhai Li [email protected]Science13 Oct 2022Vol 378, Issue 6616p. 148 PREVIOUS ARTICLEChile’s monoculture plantations must adaptPreviousNEXT ARTICLEIn Science Journ…
On 30 May, the Chilean Climate Change Framework Law was enacted to address climate change challenges and decrease Chile’s greenhouse gases with a goal of emissions neutrality by 2050 (1). The framework includes climate change mitigation through nature-based solutions such as carbon sinks (i.e., trees and soils that absorb more carbon than they release) in native forests and plantations with native species, but it discourages monoculture plantations. The strategies in the law underestimate the potential environmental value of monocultures.
HomeScienceVol. 378, No. 6616Expand native vegetation in Chile’s citiesBack To Vol. 378, No. 6616 Full accessLetter Share on Expand native vegetation in Chile’s citiesJuan L. Celis-Diez [email protected] and Nélida PohlScience13 Oct 2022Vol 378, Issue 6616p. 147 PREVIOUS ARTICLENatural monumentsPreviousNEXT ARTICLEChile’s monoculture plantations must adaptNext ContentsReferences and Notes …
Reverence for old trees sparked early forest conservation efforts, even as ancient woodlands were cut with impunity
A pair of authors urge readers to confront society’s shortcomings and build a better future
In October 1962, the United States and the Soviet Union squared off in what game theorist and Nobel laureate Thomas Schelling described as a nuclear game of “chicken” that threatened humanity’s survival. The Cuban Missile Crisis spurred six decades of ...
A ligand deprivation–dependent activation system helps plants tune stress responses near damaged sites.
A noninvasive neuroimaging method allows direct mapping of neuronal action potentials in a living mouse brain with high resolution.
Ancestral sequence reconstruction reveals how recruiting a new subunit primes form I Rubiscos for rising atmospheric oxygen.
Mutations helped reptiles survive thin air and bitter cold—and even find warm bathing spots
Increasingly intense heat waves, wildfires, and droughts are forcing costly adaptations
Researchers say the government tightly controls—and sometimes disputes—population estimates for endangered species
The recent firing of Maitland Jones Jr. by New York University (NYU) has captured the attention of many quarters in higher education and science in the United States. Jones, a celebrated organic chemistry professor at Princeton University, who retired and ...
Structural analysis reveals molecular mechanism of preinitiation complex–Mediator organization on chromatin RNA polymerase II–mediated eukaryotic transcription initiation.
Two high-entropy alloys with extremely low thermal expansion were found with the help of machine learning.
A single-nucleotide polymorphism in a brain-specific enhancer is directly responsible for increasing the risk of glioma.
Expecting perfection impedes progress in the march toward digital equality, argues a legal scholar
Tulio de Oliveira’s team warned the world of Omicron. Now, he’s insisting African research take its place on the world stage
This summer, seabirds in Europe, North America, and Africa suffered unprecedented high mortality as highly pathogenic avian influenza (HPAI) swept through their breeding colonies. Given that the potential for HPAI—which originated in farmed poultry—to ...
FULL ACCESSLetterNextGen Voices: Ask a Peer Mentor Share on When internships disappointRui Tang [email protected], Tina Bharani [email protected], Jian Ding [email protected], Kefeng Li [email protected], Ju Wen [email protected], Suchitra D. Gopinath [email protected], Teng-Jui Lin [email protected], … Show All … , Jay X. J. Luo [email protected], Qianjun Wen [email protected], Katherine Davis, N…
By sequencing genomes of extinct hominins, Pääbo explored “what makes us uniquely human”
A high-throughput virtual screen followed by experimental testing generates therapeutic leads for non-opioid pain killers
A review discusses how molecular and genetic tools provide insights into the biology of disease transmission by arthropod vectors.
Variation in life span is the consequence of sex- and age-dependent genetic effects and early access to nutrients.
The United States and Japan are embarking on ambitious efforts to wring a key secret of the universe from the subatomic phantoms known as neutrinos
For 25 years, the US government funded little research on firearm violence prevention. Although some dedicated researchers made important discoveries over this period, the scale of the research effort was not commensurate with the problem. Recently, ...
Isotope measurements suggest that collisional erosion has an outsized role for understanding Earth’s element distribution.
An insider’s guide to visual reasoning celebrates those who think in pictures and patterns
Antibiotics are frequently used to treat or prevent bacterial infections in humans, animals, and crops. Later, the drugs end up in the environment, particularly the water supply, through wastewater, excrement, or groundwater. Because testing for antibiotics in drinking water (even bottled water) is rare, people consume them unknowingly (1). Extensive human exposure to low-dose antibiotics can lead to decreased response to antibiotics when they are needed (2), and antimicrobial resistance is growing (3). Therefore, governments worldwide should work to identify, prevent, and remediate antibiotic contamination of water sources (4).
The information and communications technology (ICT) industry, which includes telephone and computer networks and devices, has the potential to reduce emissions and increase efficiency in other industries by using internet platforms to connect equipment, production lines, factories, suppliers, products, and customers (1). The ICT industry is expected to help reduce global carbon emissions by 20% by 2030 (2). However, the industry’s own carbon emissions could undermine its positive contributions. Although carbon emissions produced by the ICT industry accounted for only about 1% of total global carbon emissions in 2007, without interventions, the number could reach 14% by 2040 (3). In China, where the ICT industry is growing rapidly (4), the government must ensure an environmentally responsible transition.
FULL ACCESSLetter Share on Monoculture plantations fuel fires amid heat wavesJ. Barquín [email protected], L. Concostrina-Zubiri, I. Pérez-Silos, G. Hernández-Romero, A. Vélez-Martín, and J. M. Álvarez-MartínezScience29 Sep 2022Vol 377, Issue 6614p. 1498DOI: 10.1126/science.ade5923 PREVIOUS ARTICLEHigh on the Hog: A Culinary Journey from Africa to AmericaPreviousNEXT ARTICLEA low-carbon future for…
FULL ACCESSBooks et al.Podcast Share on High on the Hog: A Culinary Journey from Africa to AmericaHigh on the Hog: A Culinary Journey from Africa to America Jessica B. Harris Bloomsbury, 2011. 304 pp.Science29 Sep 2022Vol 377, Issue 6614p. 1497DOI: 10.1126/science.ade8448 PREVIOUS ARTICLESpatial thinkers receive their duePreviousNEXT ARTICLEMonoculture plantations fuel fires amid heat wavesNext …
Tenure delays and pandemic impact statements could magnify bias against underrepresented groups
Emerging subvariants have hit on a combination of mutations that makes them more immune evasive than ever
Judges on China Initiative cases reject claims that defendants defrauded agencies by not disclosing foreign connections
A classical machine learning algorithm is proven to be computationally efficient for some many-body problems.
Correcting neonatal glutamatergic deficit delays onset of Huntington’s disease in adult mice.
Signals that coordinate the twisting formation of the vertebrate gut rely on mechanical cues.
Neuroscientists will build on census of mouse brain as massive program moves into new phase
Macrophages selectively expand or eliminate individual stem cells during development on the basis of surface calreticulin.
It’s easy to be discouraged by the apparently grim state of science communication. Politicians and charlatans are promoting conspiracy theories about everything from COVID-19 to climate change. Scientists are ignored by friends and relatives who would ...
Scientists are exploring new material designs to make smaller and denser pixel displays
Modification of cerebral vasculature helps to cushion the brains of whales and dolphins against injury
Correcting synaptic defects in development delays Huntington’s disease symptoms in older mice
Liver-derived coagulation factor XI induces a cardiac signaling pathway that protects from heart failure.
The US military’s eye-watering carbon footprint must be mitigated, argues a political scientist
FULL ACCESSLetter Share on Education can improve response to flash floodsLu Wang, Ruihua Nie, Louise J. Slater, Zhonghou Xu, Dawei Guan, and Yifan Yang [email protected]Science22 Sep 2022Vol 377, Issue 6613pp. 1391-1392 PREVIOUS ARTICLEDigital spaces and their perilsPreviousNEXT ARTICLETime to improve disaster preparedness in BrazilNext References and NotesWater rushes down stairs in a New York…
Extreme events are growing in frequency and intensity worldwide (1). In Brazil, national policy exacerbates natural disasters by failing to consider risk reduction. Real estate speculation and construction encourage urban development in risky locations, such as areas close to water bodies and high slopes (2, 3), and efforts to raise public awareness of the risks are rare. The next administration should take steps to improve the country’s disaster prevention and response.
Brazil exports more than 100 tons of gold annually, about 20% of which is produced illegally (1). Illegal gold mining in the Amazon region of Brazil has increased substantially in the past few years, as inspections and penalties for violators have diminished (2, 3). The gold mining process has led to mercury contamination in Brazil’s waterways (4, 5). When consumed by humans, mercury damages the central nervous system and disrupts the metabolic function of organs (6). Brazil’s government must step in to protect the country’s population by enforcing mining laws and limiting mercury use.
Whole families may have come across the North Sea starting around 450 C.E., ancient DNA reveals
Ambitious $746 million program aims to complement big neuroscience projects in Europe and the United States
Perseverance set to drop organic-rich sample cache for pickup—and eventual scrutiny in terrestrial labs
Company reports first benefits to patients from injecting the molecular gene-editing tool into the blood
Translocation biogenesis in murine and human cells is driven by shared early DNA replication timing of partner loci.
Russia’s invasion of Ukraine continues to have a devastating effect on the well-being of Ukrainians and their economy (1). The tragic human consequences will be compounded by the long-term ecological implications of the war, such as the contamination of soil and water by the weaponry and other pollutants, wildfires and disruptions to ecosystem structure and services, and the environmental impact of the eventual postwar rebuilding activities (2, 3). Ongoing hostilities in the vicinity of the Zaporizhzhia Nuclear Power Station (the biggest in Europe) highlight the risks of large-scale nuclear disaster (4). To prepare for Ukraine’s recovery, we need to understand both the current and longterm environmental impacts of the war (2–5).
Synchronized activation of DNA replication origins induces genetic instability in lymphoma
The Science family mourns longtime copyeditor Jeffrey Cook, who died unexpectedly last month. Jeff joined AAAS in 1994. He was a true perfectionist and cared deeply about language, editing, and scientific communication. Thousands of Science papers published over the past three decades are clearer and more accurate because of Jeff’s meticulous dedication to his craft. He deftly transitioned from the hardcopy era to the world of online publication. Beyond being a mainstay of the Editorial team, Jeff was an accomplished musician and multi-instrumentalist. When Science launched its weekly podcast in 2007, Jeff composed the theme music, which still welcomes listeners to this day. Jeff was kind, talented, and thorough. He will be missed.
Saturn’s rings could have formed by ripping apart a former moon of the giant planet, scattered by orbital resonances.
A structure reveals insights into how a human bitter taste receptor recognizes a ligand and transduces the signal.
FULL ACCESSLetter Share on A genomics revolution in amphibian taxonomyChristophe Dufresnes [email protected] and Daniel JablonskiScience15 Sep 2022Vol 377, Issue 6612p. 1272DOI: 10.1126/science.ade5002 PREVIOUS ARTICLEDos and don’ts for achieving managerial diversityPreviousNEXT ARTICLEComprehensive support for diversity in STEMNext References and NotesAmphibians feature the highest rates of bo…
The ocean is Earth’s greatest climate mitigator, but it cannot do its work without biodiversity. Yet, accelerating climate change, unsustainable fishing, and widespread plastic and other pollutants, combined with increased resource demands, are ...
A data-driven and policy-supported strategic use of aquifers for irrigation is needed to maximize their benefits
Skip the metaphors—physics needn’t be diluted for nonexperts to achieve real understanding
A pair of sociologists turn to data to determine how to diversify organizations’ upper ranks
In their Policy Forum “Achieving STEM diversity: Fix the classrooms” (3 June, p. 1057), J. Handelsman et al. explain that past interventions have not resulted in equitable representation for students from historically excluded communities in science, technology, engineering, and mathematics (STEM). We agree that implementation of their suggested classroom changes would likely contribute to greater persistence and retention in STEM throughout college. However, fixing the classroom alone will not be sufficient. If we are to achieve a fully inclusive workforce (1, 2), we need a comprehensive approach that simultaneously and collaboratively addresses factors both within and outside the classroom (3).
New York state has declared an emergency, yet scientists say a big U.S. outbreak is unlikely
Computer simulations and lab experiments will help interpret test collision, revealing which strategies might save Earth from a real threat
A review shows that most tropical deforestation is associated, directly or indirectly, with agriculture.
Neocortical neurogenesis in modern humans differs from that likely to have been observed in Neanderthals, yielding more cortical neurons.
Ancient and modern genomes elucidate the origins, spread, and management practices underlying donkey domestication.
A combined computational strategy was used to understand the properties of the cuprate parent state from first principles.
Massive investments initially helped drive down cases, but now they’re plateauing—and going up in some places
Thermal conductance of an isolated fractional quantum Hall edge state at 5/2 filling reveals its topological order.
Recent declines in monkeypox infections have elicited comments such as “cautiously optimistic” and “we’re turning a corner.” Indeed, this trend in large cities in the United States and Europe, as well as a global decline in new cases of 21% (according to ...
FULL ACCESSIn BriefSCI COMMUN Share on News at a glanceScience8 Sep 2022Vol 377, Issue 6611pp. 1130-1131DOI: 10.1126/science.ade7659 PREVIOUS ARTICLEProtect the vulnerable from monkeypoxPreviousNEXT ARTICLETwisty device explores alternative path to fusionNext Webb telescope snaps its first exoplanetLung cells give yaks a high-altitude edgeNext U.K. PM a cipher on scienceEarliest known amputatio…
Scientists call for concerted effort to forecast points of no return for ice, weather patterns, and ecosystems
FULL ACCESSPerspectiveViewpoints: COVID-19 Share on COVID-19 and childrenCarl A. Pierce, Kevan C. Herold [email protected], Betsy C. Herold [email protected], Janet Chou [email protected], Adrienne Randolph, Binita Kane [email protected], Sammie McFarland, Deepti Gurdasani [email protected], Christina Pagel [email protected], Peter Hotez [email protected], Sarah Cobey [email protected], and Scott …
Clinical practice, data collection, and medical AI constitute self-reinforcing and interacting cycles of exclusion
Vietnamese refugees faced misdirected rage for a marine ecosystem ravaged by industry, argues a journalist
FULL ACCESSLetter Share on Joint protection of a crucial reef ecosystemYoufang Sun, Lintao Huang, Laurence J. McCook, and Hui Huang [email protected]Science8 Sep 2022Vol 377, Issue 6611p. 1163DOI: 10.1126/science.abo0166 PREVIOUS ARTICLEA tale of troubled watersPreviousNEXT ARTICLEAdaptive wildfire mitigation approachesNext References and NotesChina has taken steps to protect the South China Se…
Wildfires have been increasing in frequency, severity, and intensity in many landscapes worldwide. The trends are driven by climate change (1), changes in land management (2) and land cover (3), logging (4), and ineffective fire mitigation actions (5). As a result, extensive parts of some landscapes are now extremely flammable and will remain so for decades to come (6). Improving fire management, especially early detection, will require new technologies and strategies (7, 8).
In China, decades of industrialization and growing cities have replaced coastal mudflats, sandy beaches, mangroves, and rocky reefs with engineered structures such as seawalls, break walls, and dikes (1–3). The loss of coastal wetlands exposes coastal cities and communities to substantial damages from storms (4) and extreme events, which are increasing in frequency, intensity, and scale (5). The degradation of coastal ecosystems also threatens migratory birds, which depend on the wetland habitats along their flyway (6). To conserve and restore natural coastlines, policies must prioritize quantitative local assessments of successes and failures and use that information to guide national and regional priorities.
Evolutionary innovations in the vertebrate forebrain are revealed by multimodal analyses of salamander neurons.
Molecular analysis of axolotl brain cells sheds light on evolutionary conservation, neural differentiation, and regeneration.
Developmental and regenerative processes in the axolotl brain are revealed by single-cell analyses.
In a mouse model and in patients, cognitive symptoms of Down syndrome respond to restoration of gonadotropin-releasing hormone.
The mammalian and reptilian brains both result from parallel diversification processes from common ancestral neuron type families.
Comparative transcriptomics could reveal patterns of cell type evolution in the tetrapod brain
FULL ACCESSBooks et al.Fall Books Share on Readings for a season of reflectionMarie Vodicka [email protected], Josh Trapani [email protected], Matthew Diasio [email protected], Carolyn Wong Simpkins [email protected], Ruthanna Gordon [email protected], Adam R. Shapiro [email protected], David M. Kahler [email protected], Ilana Goldberg [email protected], and Kasra Zarei [email protected]The Song o…
Climate change impacts—including flooding, wildfires, and crop failures—are destroying ecosystems, homes, infrastructure, farms, and businesses. Regulators around the globe are paying increasing attention to what these events mean for banks and the ...
Scientists apply research tools to help find the remains of long-missing service members
FULL ACCESSLetter Share on Test Patagonia’s raptors for rodenticidesMiguel D. Saggese, Pablo Plaza, Laura Casalins, Gala Ortiz, and Valeria Ojeda [email protected]Science1 Sep 2022Vol 377, Issue 6610p. 1054DOI: 10.1126/science.ade2357 PREVIOUS ARTICLEReadings for a season of reflectionPreviousNEXT ARTICLEDenmark passes total ban of leaded ammunitionNext References and NotesBarn owls (Tyto alba …
Nanocrystals are connected to form complex 3D structures by means of two-photon lithography
Observations of slip amplitude on the surface of a metal after deformation predict fatigue strength.
The use of leaded ammunition has caused collapses of raptor populations worldwide due to secondary lead poisoning (1–3). In Europe, lead kills millions of wild birds each year, and the losses in biodiversity, environmental health, and socio-economic activities are estimated to be more than 1 billion EUR (4). There is no tolerable lead intake for humans (5). In June, Denmark took an important step to address the harm caused by lead: The country will ban the use of all kinds of leaded ammunition for hunting as of April 2024 (6).
Pollinators play an irreplaceable role in ensuring food security and maintaining ecosystem stability. Worldwide, 87.5% of angiosperms, more than 70% of crops, and more than 35% of food production depend on animal pollination, primarily by insects (1–3). However, pollinator populations and diversity are declining across the globe (4). The situation is particularly dire in China, where the distribution areas of the two most important indicator species, Apis cerana Fabricius and Bombus chinensis, are rapidly decreasing (5–8). If China does not take steps to address the threats to pollinators, their decline could lead to systemic ecological risks and food shortages.
COVID-19 vaccines get their first update since the pandemic began. Here's what you need to know about them
Webb telescope’s first exoplanet result could help scientists understand how planets form
Machine learning and multiplexed screening elucidates enhancer networks regulating gene expression in health and disease states.
Release of α-melanocyte stimulating hormone from the pituitary gland interferes with antitumor immunity.