Before We Die: Recent Episodes

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Before We Die follows the stories of the brave, audacious, and stubbornly persistent problem-solving gizmologists from the Med-Tech world. Join us as top doctors, scientists, bio-designers and entrepreneurs share their stories of unimaginable successes and heartbreaking failures as they strive to bring their life-saving technology and diagnostic innovations to the patients who need them the most. The Med-Tech industry is booming but the obstacles and delays are an endless challenge. Can healthcare catch up with innovation? With an emphasis on the patient perspective, hosts Joey Brenneman, Sandra Miller, John MacMahon, and Craig Ullman lend their humor and expertise to explore the stories behind the people and companies driving a billion dollar healthcare market. In addition to Before We Die, you'll also have access to Lab Before Slab, the tangential conversation mini-podcast where Sandy, John and Craig geek out about the latest happenings in the med-tech field.

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Sandy brings up an Austrian health device from Breatheilo.com, that uses breath to analyze the menstrual cycle during the entire month and makes recommendations to boost one's daily health. This leads to personal revelations on the part of our panel and a discussion of raspberries.

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SHOW NOTES:Breatheilo

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Sam Mazin asked a question in a college lecture class that launched his life's work and his company, Reflexion Medical. Reflexion Medical uses Biology-Guided Radiotherapy or BGRT to provide radiation treatment in real time. Join us to understand what all of this means. The implications for late stage cancer patients are incredibly hopeful.

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SHOW NOTES: Reflexion Medical

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Many restaurants post the calories for each dish, but it doesn’t seem to change most people’s behavior. Norwegian scientists created an app to tell you how the calories you eat affect your life expectancy. Will that change your behavior? Answer from panel: electric shocks might be better.

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When you think of innovation, Vitamin D is not necessarily the first thing that comes to mind. But meet 92-year old Dr. Hector DeLuca. He has spent his life researching Vitamin D and still finding exciting new information. Dr. DeLuca is an emeritus professor at the University of Wisconsin where he has three buildings named after him for his immense contributions and discoveries. He has made 8 drugs during his lifetime involving vitamin D, has numerous patents and has been nominated twice for The Nobel. He has recently received his first device patent and is currently studying the effects of UVB light therapy and its healing properties, specifically in MS patients and also its affect on the immune system.

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The pandemic forced people to use telehealth — and they liked it. Now that we’ve decided to live with the pandemic, a number of states are going back to banning out-of-state doctors. Is this good because states are licensing doctors, and they should be licensed to protect the public? Or is it bad because people need access to specialists in other states? What do we do if both are true?

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Psoriasis not only takes a toll on those who suffer from it, it can also take a toll on the inventors who find more effective treatments for it. Evan Anderson is a medical engineer who found a better way to treat this debilitating disease. He formed a company, created the product, and started to treat patients...and then things got really complicated. Join us to learn about this battle and see who won.

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20-50% of all prescriptions are off-label — prescribed by doctors for conditions that the drug wasn’t approved for. Doctors don’t want to talk about off-label prescriptions because insurance companies would have an excuse not to pay for it. Are we trusting our doctors too much? Or is something more basic wrong with the system?

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Patients with Glioblastoma brain tumors, require more than just brain surgery. After the procedure they have a high likelihood of recurrence at the same site of the original tumor. The standard of care to slow this recurrence is a series of in-hospital radiation treatments, limiting the patient's quality of life without providing the expectation of a cure. Enter the amazing Gamma Tile -- a collagen-based tile carrying gamma-ray emitting isotopes. Think of it as a radioactive postage stamp that surgeons can place during the initial surgery, eliminating the need for returning to the hospital as well as being more convenient and effective. A win for the patient's quality of life, reducing costs, and in the early series so far, improving survival by 7 months. Joining us to discuss this amazing advancement is Matthew Likens, CEO of GT Medical. Matt shares the success story of Gamma Tile and the struggles in bringing a new product to market during a pandemic.

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SHOW NOTES: GT Medical. https://gtmedtech.com/

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Med tech companies live or die based on approvals by the FDA. Hosts John MacMahon and Sandy Miller relate from their own experiences how previous FDA management was hard to predict and decisions often seemed erratic. This led to many companies moving their testing to Europe enabling Europe to bring new medical technologies to patients much sooner than the US. But a more effective, better informed FDA has reversed this trend and the United States has risen to the top for medical device testing and treating of patients.

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After observing numerous brain surgeries, Kate Rosenbluth asked a question to a group of neurosurgeons. When their response was, I can't believe we didn't think of that, she knew that she was onto something. Her device, the Cala Trio, is a new, non-invasive option for essential tremor. Until now, the only other options were prescription medicine or brain surgery. Follow us on Kate's journey along with CEO of Cala Health, Renee Rosenbluth, who immediately understood Kate's vision and pushed her to start the company shortly after delivering her second child. Electricity as medicine is not a new concept but the places that Cala Health is taking it is radically new -- and quite stimulating! (sorry)

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SHOW NOTES: For more info on the Cala Trio and Cala Health https://calahealth.com/

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Car T-cells are a type of white blood cell that scientists are trying to manipulate to empower the immune system in the fight against cancer, but clinical trials typically rely on the most willing population — white males, who aren’t representative of anyone other than white males. So how do you broaden the trial population to be more representative? It ain’t easy.

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As a professor at the Stanford School of Medicine, Dr. Paul Yock wanted to find a way pay it forward. Stanford BioDesign is the result of that vision. Along with our very own Sandra Miller, they created a program that brought together problem solvers from different fields and taught them how to form cross-discipline teams identifying and solving patients' needs. The program's inception tapped into the substantial resources of Stanford and the Silicon Valley medTech community to support emerging med-tech innovators. Entering its third decade, the Stanford Byers Center for Biodesign, as it is now known, has generated medical technologies and inspired similar training programs in over 17 countries. The question that drove the biodesign program was, "Can innovation be taught?" And the answer is a resounding YES! The center has reached over 7.6 million patients (and counting) with technologies initiated by trainees in the program.

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SHOW NOTES: The Future of Health Care | Stanford Byers Center for Biodesign | Stanford Medicine

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Scientists at Baylor and Stanford are researching a simple protein that may be able to reduce your caloric intake. John objects and blames the patients. The other hosts are the patients and object to John. Sandy plays the electric bike card. Craig accuses John of having a romantic notion of neurochemistry, which leads, of course, to bears.

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There are exciting advances happening in the med-tech world and patients are the last to know. Sandra Miller, John MacMahon and Craig Ullman join forces to share their humor and expertise about the med tech world in this patient-centered podcast. Innovation is happening and the devices that are emerging have the ability to save or significantly change the lives of patients for the better. Hear about new options and why it takes so long to get these new technologies to the patients who need them.

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Meet Dr. Paul Yock! Dr. Yock is famous for fundamentally improving cardiac interventions over his entire career. He walks us through the basics of a heart attack and how they were treated from the time his career began to now. His Rapid Exchange (RX) catheter innovation "rapidly" became the global standard. As the treatment for heart attack evolved to include cardiac stents, he next invented a catheter to see inside the patient's arteries and optimize stent deployment and patient outcomes. Dr. Paul Yock has won awards as an engineer as well as a cardiologist and is the founding director of the Stanford Byers Center for Biodesign dedicated to advanced training and medical technology. Even with all of his incredible achievements, Dr. Paul Yock is very down to earth and fascinating to talk to. Hear about heart attacks from the cardiologist who continues to learn from them!

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Show Notes:

More about Dr. Paul Yock here: https://profiles.stanford.edu/paul-yock

If you're a patent geek, here's the link for Paul Yock's patents https://patents.justia.com/inventor/paul-yock

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Lab Before Slab is the mini-pod companion to the Before We Die Podcast. These are the conversations that happen around our virtual production table when we should be doing other things. But often, these seemingly random conversations lead to interesting thoughts and topics and we wished that we recorded them. One day we did and thus, the Lab Before Slab mini-pod emerged.

Join us as Sandy Miller, John MacMahon, Craig Ullman and Joey Brenneman geek out about happenings in the med-tech world. You never know where the Lab Before Slab conversation is gonna go!

Often fascinating, always a little bit quirky, Lab before Slab is a bite-sized episode that drops between the full length Before We Die interviews.

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Your health is at stake. Are there medical innovations that could save your life? Or even just make your day to day living a little more comfortable?

Join us for Before We Die, a roundtable conversation podcast that will open the door to the world of medical technology and introduce you to the innovators who tackle health problems in search of a better or less invasive way.

Along with co-host Joey Brenneman, the Before We Die creators and panel of experts, Sandra Miller, John MacMahon and Craig Ullman, will lend their humor and expertise to discuss the stories of a multi-billion dollar med-tech industry.

Each week features a rock star innovator or expert from the med-tech field. They share stories of their successes and failures as they travel the long road to get their incredible and often lifesaving devices to the patients who need them the most.

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