Modern Healthspan: Recent Episodes
Modern Healthspan
Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A
DESCRIPTION
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. We talk to him about the results to the TRIIM follow up trial, TRIIM-XA, further trials in the works and plans for getting the TRIIM protocol into the clinic.
🌐Links in this Interview
Intervene Immune website:
http://interveneimmune.com/
Reversal of epigenetic aging and immunosenescent trends in humans – The original TRIIM trial paper.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826138/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
Description
Hi all, apologies for the erratic release schedule recently. We have now changed the way that we release interviews on our YouTube channel and from now on will post the whole interview in a single video. The podcasts will follow the same pattern. This will mean that we have fewer, though longer podcasts. I hope that this works for you all.
Thanks Richard
Dr Keirstead talks about his work with stem cells and using the factors that young stem cells secrete to rejuvenate the immune system which then has systemic effects across the whole body. Dr Keirstead's therapy is currently in phase 1/2a human trials.
Some links are affiliate links so we will earn a commission when they are used to purchase products.
🌐Links in this Interview
Immunis Website https://immunisbiomedical.com/
The two papers published on preclinical trials of Immuna. Both are open access
Stem cell secretome treatment improves whole-body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice
https://onlinelibrary.wiley.com/doi/10.1111/acel.14144
Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8602548/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Hi all, apologies for the erratic release schedule recently. We have now changed the way that we release interviews on our YouTube channel and from now on will post the whole interview in a single video. The podcasts will follow the same pattern. This will mean that we have fewer, though longer podcasts. I hope that this works for you all.
Thanks Richard
Dr. Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He was the first to demonstrate and discover an endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite. Through the drug discovery program in natural product chemistry, Dr. Bryan discovered unique compositions of matter than can be used to safely and effectively generate and restore nitric oxide in humans. This technology is now validated in six published clinical trials. He is also a successful entrepreneur who has commercialized his nitric oxide technology through the formation of Human, to the Power of N, Inc (formerly Neogenis Labs) where he is a Founder and inventor. Dr. Bryan has been involved in nitric oxide research for the past 18 years and has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in many chronic diseases. Dr. Bryan has published a number of highly cited papers and authored or edited 5 books. He is an international leader in molecular medicine and nitric oxide biochemistry.
Dr Bryan talks about why nitric oxide is so essential to our health and longevity. It is well known as a vasodilator which helps with CVD risk but it also impacts dementia and metabolic syndrome.
🌐Links in this interview
Dr Nathan's Website https://drnathansbryan.com/
Bryan Therapeutics Inc: https://www.bryantherapeutics.com/
n1o1 website https://n1o1.com/
YouTube Channel https://www.youtube.com/channel/UCtftGy8e0r9DO8ActcyGi4w
n1o1 Nitric Oxide 10% discount with code Modern https://tinyurl.com/3esakm4s
n1o1 Nitric Oxide Lozenges https://tinyurl.com/yh4rrtht
Age-Defiance Face Cream https://tinyurl.com/4zr959zh
N.O.Beetz https://tinyurl.com/48cujze4
Pure Clean Performance: 15% discount code Modernhealth15 http://tinyurl.com/msspanpw
Nitric oxide strips https://tinyurl.com/4tzmjazp
Pure Clean Beets https://tinyurl.com/bdfhfanw
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Reis talks about what causes aging of the skin, and UVB is one of the main causes and what her longevity protocol looks like.
Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area.
🌐Links in this episode
OneSkin's website
https://www.oneskin.co/
OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8
Related publications:
https://www.oneskin.co/pages/publications
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Reis talks about some of the customer feedback that they have received. The feedback is available at the bottom of the product pages on the OneSkin website.
Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area.
🌐Links in this episode
OneSkin's website
https://www.oneskin.co/
OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8
Related publications:
https://www.oneskin.co/pages/publications
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Reis talks about the human as well as in vitro trials that her company is doing. The papers can be found on the OneSkin website (including the one that she refers to in the video as being published in the next week)
Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area.
🌐Links in this episode
OneSkin's website
https://www.oneskin.co/
OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8
Related publications:
https://www.oneskin.co/pages/publications
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Reis talks about the new series of products that the team at OneSkin have developed, including for body, eyes, sun protection and a cleanser.
Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area.
🌐Links in this episode
OneSkin's website
https://www.oneskin.co/
OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8
Related publications:
https://www.oneskin.co/pages/publications
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Reis talks about the development of OS-1 the peptide used in One Skins products, its senomorphic effects and other ingredients which are included in the One Skin product range.
Dr. Carolina Reis is the co-found and CEO of OneSkin Technologies. She holds a biochemistry degree and a Ph.D. focused on stem cell and tissue engineering. After more than 10 years of developing science in academia, she is thrilled to translate basic science into products that will extend our healthspan. As a founder of OneSkin, she and the team have been working to develop the first anti-senescence topical product designed to promote skin health from within. Dr. Reis is an alumnus of IndieBio, the world's largest seed biotech accelerator. She has moved from Latin America to Silicon Valley 4 years ago to found OneSkin and has been actively engaged in the longevity ecosystem in the Bay Area.
🌐Links in this episode
OneSkin's website
https://www.oneskin.co/
OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8
Related publications:
https://www.oneskin.co/pages/publications
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Trommelen talks about practical take aways from his study. How much protein should we eat, how often and what type is best. He also talks about his personal protocol.
🌐Links in this episode
Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes.
The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/
Dr Trommelen's page https://www.nutritiontactics.com/
On twitter: https://twitter.com/JornTrommelen
Facebook : https://www.facebook.com/nutritiontactics/
Instagram: https://www.instagram.com/nutritiontactics/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Trommelen talks about how the MPS continues for more than 12 hours, because of the presence of amino acids in the blood, however, mTOR does not appear to be activated and autophagy is not suppressed and provides his explanation for these findings.
🌐Links in this episode
Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes.
The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/
Dr Trommelen's page https://www.nutritiontactics.com/
On twitter: https://twitter.com/JornTrommelen
Facebook : https://www.facebook.com/nutritiontactics/
Instagram: https://www.instagram.com/nutritiontactics/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Trommelen talks about the amount of protein required to initiate MPS, what muscle break down is and how MPS is measured. Key take away: It is muscle synthesis which determines muscle mass much more then breakdown as breakdown remains in a very tight range.
🌐Links in this episode
Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes.
The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/
Dr Trommelen's page https://www.nutritiontactics.com/
On twitter: https://twitter.com/JornTrommelen
Facebook : https://www.facebook.com/nutritiontactics/
Instagram: https://www.instagram.com/nutritiontactics/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Trommelen talks about exercise and protein and how they are related to muscle protein synthesis. The importance of having both, the time window for MPS and the training stimuli required.
🌐Links in this episode
Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes.
The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/
Dr Trommelen's page https://www.nutritiontactics.com/
On twitter: https://twitter.com/JornTrommelen
Facebook : https://www.facebook.com/nutritiontactics/
Instagram: https://www.instagram.com/nutritiontactics/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Trommelen talks about the background to the study, the major results and the type of protein used.
🌐Links in this episode
Dr Jorn Trommelen works as an Assistant Professor at the Department of Human Biology at Maastricht University. He is involved in research and education regarding the impact of exercise and nutrition on muscle mass and function. His research is part of the M3 research group and focuses on exercise and nutritional interventions to augment exercise performance and training adaptations in athletes.
The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772463/
Dr Trommelen's page https://www.nutritiontactics.com/
On twitter: https://twitter.com/JornTrommelen
Facebook : https://www.facebook.com/nutritiontactics/
Instagram: https://www.instagram.com/nutritiontactics/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
Here Dr Joffrey discusses Medicine 3.0 - how you can take control of your own health and his top 10 supplements (and three drugs) for longevity.
🌐Links in this episode
Dr Joffrey's podcast on aging - free copy of his book, Longevity for Busy People is available for download from there.
https://sapiopodcast.com/ Consumer Labs
https://www.consumerlab.com/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Joffrey discusses sleep, how important it is and some tips for getting the best sleep.
🌐Links in this episode
Dr Joffrey's podcast on aging - free copy of his book, Longevity for Busy People is available for download from there.
https://sapiopodcast.com/ Consumer Labs
https://www.consumerlab.com/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Joffrey discusses exercise for longevity and how it is different from exercise for other purposes including what is the minimum effective dose. He also talks about cardiovascular disease and why we should not die from it.
🌐Links in this episode
Dr Joffrey's podcast on aging - free copy of his book, Longevity for Busy People is available for download from there.
https://sapiopodcast.com/ Consumer Labs
https://www.consumerlab.com/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Joffrey discusses the keys to a healthy diet. Time restricted feeding, controlling glucose in general and spikes in particular, and ensuring that you have sufficient protein.
🌐Links in this episode
Dr Joffrey's podcast on aging - free copy of his book, Longevity for Busy People is available for download from there.
https://sapiopodcast.com/ Consumer Labs
https://www.consumerlab.com/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Joffrey discusses his view on future of aging and the most promising technology that he sees which will make a difference. He also talks about Longevity Escape Velocity.
🌐Links in this episode
Dr Joffrey's podcast on aging - free copy of his book, Longevity for Busy People is available for download from there.
https://sapiopodcast.com/ Consumer Labs
https://www.consumerlab.com/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Matt & Wade discuss lifestyle, nutrition and supplement strategies to support cognitive performance as we get older.
The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern
Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products.
🌐Links in this episode
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Matt & Wade discuss saturated fats and proteins as part of the diet.
The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern
Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products.
🌐Links in this episode
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern
Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products.
🌐Links in this episode
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Matt & Wade discuss how to build muscle without adding fat using a cycled diet and exercise protocol. They also talk about how to measure progress, with weighing machines, tape measures, DEXA scans and photos.
Here Matt & Wade discuss how to structure a diet and some of the pitfalls that can happen in implementation.
The Ultimate Nutrition Bible can be found here https://ultimatenutritionsystem.com/modern
Our code of Modern10 will already be applied. The code will also work for all BiOptimizer products.
🌐Links in this episode
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Sorrentino discusses his personal longevity protocol and also some of his current work and how this is targeted at moving discoveries into the clinic.
Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.
🌐Links in this episode
Dr Sorrentino's page at NUS
https://medicine.nus.edu.sg/bch/faculty/vincenzo-sorrentino/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Sorrentino discusses mitochondria and muscle aging and results from trials of Urolithin A and NR in countering some of the ill effects.
Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.
🌐Links in this episode
Dr Sorrentino's page at NUS
https://medicine.nus.edu.sg/bch/faculty/vincenzo-sorrentino/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Sorrentino discusses proteostasis, how it goes wrong with age and how raising NAD levels can help.
Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.
🌐Links in this episode
Dr Sorrentino's page at NUS
https://medicine.nus.edu.sg/bch/faculty/vincenzo-sorrentino/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Apologies for missing the last two release dates. Hopefully back on track now!
Here Dr Sorrentino introduces trigonelline a methylated form of nicotinic acid which can boost NAD levels. He also talks about his work at Singapore and the translation of longevity science into the clinic.
Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.
🌐Links in this episode
Dr Sorrentino's page at NUS
https://medicine.nus.edu.sg/bch/faculty/vincenzo-sorrentino/
Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Maroon, talks about some of the latest work that they are doing at Pittsburgh University on direct stimulation of the brain with magnetic pulses, light and ultra-sound.
Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events including 8 international ironman’s. His most recent was in August 2022 at the age of 82 where he finished first in his age group..
🌐Links in this episode
Dr Maroon's website
https://www.josephmaroon.com/
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length—The difference between zero and one: A case report
https://www.frontiersin.org/articles/10.3389/fneur.2022.949536/full
Dr Maroon's books on Amazon
Square One: A Simple Guide To A Balanced Life-2nd Edition https://amzn.to/3GzICNg
Omega-3 for Optimal Life: Why You Need Fish Oil https://amzn.to/3Rz68QU
The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life https://amzn.to/48a9m2D
products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Maroon, talks about the supplements that he takes to help him with his exercise protocol.
Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events including 8 international ironman’s. His most recent was in August 2022 at the age of 82 where he finished first in his age group..
🌐Links in this episode
Dr Maroon's website
https://www.josephmaroon.com/
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length—The difference between zero and one: A case report
https://www.frontiersin.org/articles/10.3389/fneur.2022.949536/full
Dr Maroon's books on Amazon
Square One: A Simple Guide To A Balanced Life-2nd Edition https://amzn.to/3GzICNg
Omega-3 for Optimal Life: Why You Need Fish Oil https://amzn.to/3Rz68QU
The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life https://amzn.to/48a9m2D
products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Maroon, talks about stress, including eustress and distress and his way of handling stress (exercise!)
Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events including 8 international ironman’s. His most recent was in August 2022 at the age of 82 where he finished first in his age group..
🌐Links in this episode
Dr Maroon's website
https://www.josephmaroon.com/
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length—The difference between zero and one: A case report
https://www.frontiersin.org/articles/10.3389/fneur.2022.949536/full
Dr Maroon's books on Amazon
Square One: A Simple Guide To A Balanced Life-2nd Edition https://amzn.to/3GzICNg
Omega-3 for Optimal Life: Why You Need Fish Oil https://amzn.to/3Rz68QU
The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life https://amzn.to/48a9m2D
products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Maroon, talks his personal diet and his thoughts on protein intake, sarcopenia, the ketogenic diet and omega-3 fatty acids.
Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events including 8 international ironman’s. His most recent was in August 2022 at the age of 82 where he finished first in his age group..
🌐Links in this episode
Dr Maroon's website
https://www.josephmaroon.com/
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length—The difference between zero and one: A case report
https://www.frontiersin.org/articles/10.3389/fneur.2022.949536/full
Dr Maroon's books on Amazon
Square One: A Simple Guide To A Balanced Life-2nd Edition https://amzn.to/3GzICNg
Omega-3 for Optimal Life: Why You Need Fish Oil https://amzn.to/3Rz68QU
The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life https://amzn.to/48a9m2D
products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Maroon, talks about research that he is working on with a colleague in India, Dr Pravat Mandal looking at ROS as a cause of Alzheimer's and glutathione as a possible preventative measure.
Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events including 8 international ironman’s. His most recent was in August 2022 at the age of 82 where he finished first in his age group..
🌐Links in this episode
Dr Maroon's website
https://www.josephmaroon.com/
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length—The difference between zero and one: A case report
https://www.frontiersin.org/articles/10.3389/fneur.2022.949536/full
Dr Maroon's books on Amazon
Square One: A Simple Guide To A Balanced Life-2nd Edition https://amzn.to/3GzICNg
Omega-3 for Optimal Life: Why You Need Fish Oil https://amzn.to/3Rz68QU
The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life https://amzn.to/48a9m2D
products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Maroon, discusses his path to becoming a triathlete, his exercise protocol and his experience with hyperbaric oxygen therapy.
Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to compete in triathlons in his 40’s he has completed more than 70 Olympic distance events including 8 international ironman’s. His most recent was in August 2022 at the age of 82 where he finished first in his age group..
🌐Links in this episode
Dr Maroon's website
https://www.josephmaroon.com/
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length—The difference between zero and one: A case report
https://www.frontiersin.org/articles/10.3389/fneur.2022.949536/full
Dr Maroon's books on Amazon
Square One: A Simple Guide To A Balanced Life-2nd Edition https://amzn.to/3GzICNg
Omega-3 for Optimal Life: Why You Need Fish Oil https://amzn.to/3Rz68QU
The Longevity Factor: How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life https://amzn.to/48a9m2D
products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Seranova talks about the supplements she takes, and a couple that she does not. Also sleeping and a hack for getting better deep sleep. The new brain supplement that Dr Seranova talks about is now available.
Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.
🌐Links in this episode
NMN Bio website: https://nmnbio.co.uk/
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
https://pubmed.ncbi.nlm.nih.gov/28330719/
40 Hz frequency studies:
Human study from MIT: https://picower.mit.edu/news/small-studies-40hz-sensory-stimulation-confirm-safety-suggest-alzheimers-benefits
Parkinson's disease study: https://www.mdpi.com/2227-9032/8/2/113
Mouse study: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1129510/full10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Seranova talks about her diet and exercise and how she thinks about these.
Some links are affiliate links so we will earn a commission when they are used to purchase products.
Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.
🌐Links in this episode
NMN Bio website: https://nmnbio.co.uk/
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
https://pubmed.ncbi.nlm.nih.gov/28330719/
40 Hz frequency studies:
Human study from MIT: https://picower.mit.edu/news/small-studies-40hz-sensory-stimulation-confirm-safety-suggest-alzheimers-benefits
Parkinson's disease study: https://www.mdpi.com/2227-9032/8/2/113
Mouse study: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1129510/full10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.
🌐Links in this episode
NMN Bio website: https://nmnbio.co.uk/
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
https://pubmed.ncbi.nlm.nih.gov/28330719/
40 Hz frequency studies:
Human study from MIT: https://picower.mit.edu/news/small-studies-40hz-sensory-stimulation-confirm-safety-suggest-alzheimers-benefits
Parkinson's disease study: https://www.mdpi.com/2227-9032/8/2/113
Mouse study: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1129510/full10%
NMN Bio 10% off all products https://tinyurl.com/2af2v2fw Code ModernHealthSpan10 in link
Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Seranova answers some questions on the paper from the first interview (https://youtu.be/fsuhtgKUZRg). Particular topics we discuss, mitochondria fragmentation, de novo pathway in neurons, difference between NR & NMN.
Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.
🌐Links in this episode
NMN Bio website: https://nmnbio.co.uk/
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
https://pubmed.ncbi.nlm.nih.gov/28330719/
40 Hz frequency studies:
Human study from MIT: https://picower.mit.edu/news/small-studies-40hz-sensory-stimulation-confirm-safety-suggest-alzheimers-benefits
Parkinson's disease study: https://www.mdpi.com/2227-9032/8/2/113
Mouse study: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1129510/full10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Seranova talks through her latest paper on the impact of NAD precursors (NR & NMN) on autophagy in human neuron
Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.
🌐Links in this episode
NMN Bio website: https://nmnbio.co.uk/
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer's disease by regulating intestinal microbiota
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
https://pubmed.ncbi.nlm.nih.gov/28330719/
40 Hz frequency studies:
Human study from MIT: https://picower.mit.edu/news/small-studies-40hz-sensory-stimulation-confirm-safety-suggest-alzheimers-benefits
Parkinson's disease study: https://www.mdpi.com/2227-9032/8/2/113
Mouse study: https://www.frontiersin.org/articles/10.3389/fnagi.2023.1129510/full10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Gibala talks how to think about exercise routines and nutrition as well as sharing his own protocol and the current work of his lab
Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism, his laboratory conducts applied research that examines the impact of physical training and nutrition on human health and performance. He coauthored a book for the general public on the science of time-efficient exercise, The One-Minute Workout: Science Shows a Way to Get Fit That’s Smarter, Faster, Shorter
🌐Links in this episode
World Fitness Level (online VO2max calculator) https://www.worldfitnesslevel.org
Dr Gibala's web site https://martingibala.com/
His page at McMaster University https://experts.mcmaster.ca/display/gibalam
Dr Gibala's Book on Amazon
The One-Minute Workout: Science Shows a Way to Get Fit That's Smarter, Faster, Shorter
https://amzn.to/45VCDNd
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Gibala talks about what is VO2max, why it is important, how to measure and improve it.
Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism, his laboratory conducts applied research that examines the impact of physical training and nutrition on human health and performance. He coauthored a book for the general public on the science of time-efficient exercise, The One-Minute Workout: Science Shows a Way to Get Fit That’s Smarter, Faster, Shorter
🌐Links in this episode
World Fitness Level (online VO2max calculator) https://www.worldfitnesslevel.org
Dr Gibala's web site https://martingibala.com/
His page at McMaster University https://experts.mcmaster.ca/display/gibalam
Dr Gibala's Book on Amazon
The One-Minute Workout: Science Shows a Way to Get Fit That's Smarter, Faster, Shorter
https://amzn.to/45VCDNd
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Gibala introduces interval training and discusses the various styles, and the benefits.
Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism, his laboratory conducts applied research that examines the impact of physical training and nutrition on human health and performance. He coauthored a book for the general public on the science of time-efficient exercise, The One-Minute Workout: Science Shows a Way to Get Fit That’s Smarter, Faster, Shorter
🌐Links in this episode
World Fitness Level (online VO2max calculator) https://www.worldfitnesslevel.org
Dr Gibala's web site https://martingibala.com/
His page at McMaster University https://experts.mcmaster.ca/display/gibalam
Dr Gibala's Book on Amazon
The One-Minute Workout: Science Shows a Way to Get Fit That's Smarter, Faster, Shorter
https://amzn.to/45VCDNd
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Patel talks about his topical glutathione treatment Glutaryl and the recent trial that was conducted at McGill University.
Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antioxidant Glutathione.
Dr. Patel founded Auro Wellness in 2011 to create products to help the body function at an optimal level and reduce the long-term impact of stress on the body. Through his research, Dr. Patel stabilized Glutathione, improved absorption, and increased its effectiveness with the Auro GSH™ Antioxidant Delivery System. He is the author of The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy, which addresses how powerful and essential Glutathione is to the body’s detoxification system and how to increase the body’s levels naturally.
🌐Links in this episode
Auro Wellness
https://aurowellness.com/
Paper using Auro Wellness Glutaryl
Topical Absorption of Glutathione–Cyclodextrin Nanoparticle Complex in Healthy Human Subjects Improves Immune Response against Mycobacterium avium Infection
https://www.mdpi.com/2076-3921/12/7/1375
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Patel talks about the changes that happen with glutathione as we age, why it is important and what we can do to restore the levels.
Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antioxidant Glutathione.
Dr. Patel founded Auro Wellness in 2011 to create products to help the body function at an optimal level and reduce the long-term impact of stress on the body. Through his research, Dr. Patel stabilized Glutathione, improved absorption, and increased its effectiveness with the Auro GSH™ Antioxidant Delivery System. He is the author of The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy, which addresses how powerful and essential Glutathione is to the body’s detoxification system and how to increase the body’s levels naturally.
🌐Links in this episode
Auro Wellness
https://aurowellness.com/
Paper using Auro Wellness Glutaryl
Topical Absorption of Glutathione–Cyclodextrin Nanoparticle Complex in Healthy Human Subjects Improves Immune Response against Mycobacterium avium Infection
https://www.mdpi.com/2076-3921/12/7/1375
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Patel talks about glutathione's major two functions in the body, as an antioxidant and a detoxifier. He also discusses measuring our glutathione levels and what would be a good value to aim for.
Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antioxidant Glutathione.
Dr. Patel founded Auro Wellness in 2011 to create products to help the body function at an optimal level and reduce the long-term impact of stress on the body. Through his research, Dr. Patel stabilized Glutathione, improved absorption, and increased its effectiveness with the Auro GSH™ Antioxidant Delivery System. He is the author of The Glutathione Revolution: Fight Disease, Slow Aging & Increase Energy, which addresses how powerful and essential Glutathione is to the body’s detoxification system and how to increase the body’s levels naturally.
🌐Links in this episode
Auro Wellness
https://aurowellness.com/
Paper using Auro Wellness Glutaryl
Topical Absorption of Glutathione–Cyclodextrin Nanoparticle Complex in Healthy Human Subjects Improves Immune Response against Mycobacterium avium Infection
https://www.mdpi.com/2076-3921/12/7/1375
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Conlon talks about her personal protocol, that she has decided on as a data driven scientist. We also discuss the next steps for Nuchido as a longevity company.
Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan.
Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a skill for translating advanced science to help educate and support the wider population, encouraging people to age well and achieve their optimal life experience.
🌐Links in this video
Nuchido website https://nuchido.com/
Dr Conlon's Instagram https://www.instagram.com/drnicholaconlon/ (@drnicholaconlon)
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Conlon talks about the human trial that she sponsored to evaluate the benefits of Time+ on humans.
Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan.
Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a skill for translating advanced science to help educate and support the wider population, encouraging people to age well and achieve their optimal life experience.
🌐Links in this video
Nuchido website https://nuchido.com/
Dr Conlon's Instagram https://www.instagram.com/drnicholaconlon/ (@drnicholaconlon)
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Conlon talks through all the components of Nuchido Time+ and how they fit into the strategy of restoring NAD by activating the cell's natural mechanisms.
Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan.
Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a skill for translating advanced science to help educate and support the wider population, encouraging people to age well and achieve their optimal life experience.
🌐Links in this video
Nuchido website https://nuchido.com/
Dr Conlon's Instagram https://www.instagram.com/drnicholaconlon/ (@drnicholaconlon)
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Conlon explains the biochemistry behind Nuchido Time+ and how it activates the salvage pathway through NAMPT to replenish cellular NAD in sustainable way.
Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan.
Dr Conlon has a passion for sharing the latest science and is an accomplished speaker, with a skill for translating advanced science to help educate and support the wider population, encouraging people to age well and achieve their optimal life experience.
🌐Links in this video
Nuchido website https://nuchido.com/
Dr Conlon's Instagram https://www.instagram.com/drnicholaconlon/ (@drnicholaconlon)
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Professor Gorbunova about the naked mole rat and bowhead whale and what adaptions they have to enable them to live longer. From this she discusses how these adaptions might be translated into interventions for humans.
Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat
🌐Links in this video
Dr Gorbunova's website
https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/
Sirtuin 6: linking longevity with genome and epigenome stability.
https://pubmed.ncbi.nlm.nih.gov/34281779/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Professor Gorbunova talks about hyaluronic acid, what it is and why it is different in naked mole rats. She also talks about a trial that she performed where the gene for HA was placed in mice. Finally we talk about how this could be translated into clinical usage.
Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat
🌐Links in this video
Dr Gorbunova's website
https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/
Sirtuin 6: linking longevity with genome and epigenome stability.
https://pubmed.ncbi.nlm.nih.gov/34281779/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
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Here Professor Gorbunova talks about the two functions of SIRT6, deacetylation and ribosylation, the importance of them and how they can be activated. She also touches on chromatin remodeling and Yamanaka factors.
Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat
🌐Links in this video
Dr Gorbunova's website
https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/
Sirtuin 6: linking longevity with genome and epigenome stability.
https://pubmed.ncbi.nlm.nih.gov/34281779/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Professor Gorbunova talks about the key activities of SIRT6 that are involved with longevity, particularly DNA repair and the suppression of transposons.
Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat
🌐Links in this video
Dr Gorbunova's website
https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/
Sirtuin 6: linking longevity with genome and epigenome stability.
https://pubmed.ncbi.nlm.nih.gov/34281779/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Wang talks about the current state of trials and how the therapy might eventually look.
Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cellino Biotech, where he led R&D and application of its technology to rapidly engineer cells. Stan received his Ph.D. from the University of Cambridge and his M.D. from Columbia University. He was a postdoctoral fellow in cell and gene therapy with George Church at Harvard Medical School.
🌐Links in this video
Thymmune Therapeutics https://www.thymmune.com/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
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ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
In this episode Dr Wang explains about the thymus gland and his technology for not only restoring the thymus but building new thymuses from iPCSs at scale.
Stan Wang is Founder and CEO of Thymmune Therapeutics, a cell therapy company working to address high unmet needs across immunology. Previously, Stan was Founding Chief Scientific Officer at Cellino Biotech, where he led R&D and application of its technology to rapidly engineer cells. Stan received his Ph.D. from the University of Cambridge and his M.D. from Columbia University. He was a postdoctoral fellow in cell and gene therapy with George Church at Harvard Medical School.
🌐Links in this video
Thymmune Therapeutics https://www.thymmune.com/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Tan talks about tocotrienols in bone health, what an appropriate dosage is and it is better not to take alpha tocopherol with the tocotrienols.
Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on lipid-soluble nutrients that have the potential to slow chronic conditions.
For the last 35 years, Barrie has immersed himself in the world of Vitamin E and is considered one of the world’s foremost experts, credited with commercializing tocotrienol in 3 major natural sources – palm, rice and annatto. His first discoveries were in palm & rice, but due to their high levels of tocopherol, they also lacked potency. Barrie continued his research and was soon rewarded when he found the best-in-class tocotrienol in the annatto plant!
🌐Links in this video
American River Nutrition https://americanrivernutrition.com/
Dr Tan's book, The Truth About Vitamin E, is available from https://barrietan.com/book/
You can download with the code Modern Healthspan
δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial
https://www.liebertpub.com/doi/10.1089/met.2022.0052
GG Article
https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Tan talks about the trails that have been run on tocotrienols and the results that have been seen. They have beneficial effects on a number of the markers of metabolic syndrome, such as the lipid panel and liver fat.
Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on lipid-soluble nutrients that have the potential to slow chronic conditions.
For the last 35 years, Barrie has immersed himself in the world of Vitamin E and is considered one of the world’s foremost experts, credited with commercializing tocotrienol in 3 major natural sources – palm, rice and annatto. His first discoveries were in palm & rice, but due to their high levels of tocopherol, they also lacked potency. Barrie continued his research and was soon rewarded when he found the best-in-class tocotrienol in the annatto plant!
🌐Links in this video
American River Nutrition https://americanrivernutrition.com/
Dr Tan's book, The Truth About Vitamin E, is available from https://barrietan.com/book/
You can download with the code Modern Healthspan
δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial
https://www.liebertpub.com/doi/10.1089/met.2022.0052
GG Article
https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Tan introduces the forms of vitamin E, how they are different and why this matters. He also discusses why a fat based anti-oxidant is required and where alpha tocotrienol is found in nature.
Dr. Barrie Tan was formerly an assistant professor at the University of Massachusetts in Amherst (Chemistry, Food Science & Nutrition). His mission at American River Nutrition is to deliver the highest quality nutritional products based on sound scientific research. Today, his research focuses on lipid-soluble nutrients that have the potential to slow chronic conditions.
For the last 35 years, Barrie has immersed himself in the world of Vitamin E and is considered one of the world’s foremost experts, credited with commercializing tocotrienol in 3 major natural sources – palm, rice and annatto. His first discoveries were in palm & rice, but due to their high levels of tocopherol, they also lacked potency. Barrie continued his research and was soon rewarded when he found the best-in-class tocotrienol in the annatto plant!
American River Nutrition https://americanrivernutrition.com/
Dr Tan's book, The Truth About Vitamin E, is available from https://barrietan.com/book/
You can download with the code Modern Healthspan
δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial
https://www.liebertpub.com/doi/10.1089/met.2022.0052
GG Article
https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American. In 2019, he was named one of 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine.
🌐Links in this video
Thorne https://www.thorne.com/
Age Of Scientific Wellness on Amazon https://amzn.to/3OQOZzw
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Price talks about some of the things that they learned during the pilot exercises, about biomarkers and the gut microbiome.
Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American. In 2019, he was named one of 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine.
🌐Links in this video
Thorne https://www.thorne.com/
Age Of Scientific Wellness on Amazon https://amzn.to/3OQOZzw
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Dr Price talks about the concepts of Scientific Wellness and the pilot projects that he and his team ran to try this out.
Dr. Nathan Price is the Chief Scientific Officer of Thorne HealthTech. He is co-author with Lee Hood of The Age of Scientific Wellness, and has written articles for The Wall Street Journal, LA Times, and Scientific American. In 2019, he was named one of 10 Emerging Leaders in Health and Medicine by the National Academy of Medicine, and in 2021 he was appointed to the Board on Life Sciences of the National Academies of Sciences, Engineering, and Medicine.
🌐Links in this video
Thorne https://www.thorne.com/
Age Of Scientific Wellness on Amazon https://amzn.to/3OQOZzw
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Prof Kaeberlein talks about where he sees longevity going in the near future. We also talk about personalized medicine and whether it is ready for general use.
Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project.
🌐Links in this video
Dog Aging Project https://dogagingproject.org/
Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Prof Kaeberlein discusses his thoughts on exercise and diet. In particular he goes into detail on intermittent fasting, time restricted feeding and calorie restriction.
Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project.
🌐Links in this video
Dog Aging Project https://dogagingproject.org/
Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Prof Kaeberlein talks about the million molecule challenge and why he thought that it was necessary.
Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project.
🌐Links in this video
Dog Aging Project https://dogagingproject.org/
Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Prof Kaeberlein talks about the Dog Aging Project a study which is following 100,000's of dogs to understand aging better and includes a RTC of rapamycin related to lifespan.
Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project.
🌐Links in this video
Dog Aging Project https://dogagingproject.org/
Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Prof Kaeberlein talks about the recent paper on taurine deficiency as a driver of aging and makes some comparisons between taurine and rapamycin.
Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project.
🌐Links in this video
Dog Aging Project https://dogagingproject.org/
Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here Prof Kaeberlein provides some updates on rapamycin, in particular the results from the survey based trial that his team ran and thoughts on next steps for the supplement.
Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has Fellow status in the American Association for the Advancement of Science (AAAS), the American Aging Association, and the Gerontological Society of America (GSA). Dr. Kaeberlein is currently the CEO of the American Aging Association and has served on the Board of Directors for the Federation of American Societies for Experimental Biology (FASEB), AGE, and GSA. Dr. Kaeberlein is the founding Director of the UW Healthy Aging and Longevity Research Institute, the Director of the UW Nathan Shock Center of Excellence in the Basic Biology of Aging, Director of the Biological Mechanisms of Healthy Aging Training Program, and founder and co-Director of the Dog Aging Project.
🌐Links in this video
Dog Aging Project https://dogagingproject.org/
Evaluation of off-label rapamycin use to promote healthspan in 333 adults https://pubmed.ncbi.nlm.nih.gov/37191826/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Here we discuss how to measure your gut microbiome, what the future of probiotic and gut microbiome research may hold and what Dr Cutcliffe's personal regimen is.
🌐Links in this video
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
Pendulum 20% discount with code HEALTHSPAN
Akkermansia https://www.dpbolvw.net/click-100875787-15048681
Glucose Control https://www.tkqlhce.com/click-100875787-15009432
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
Metabolic Daily is a less potent but more available form of the Glucose Control probiotic used in the clinical trial. Dr Colleen Cutcliffe discusses the differences in the formulations, the best time to take and what effects people have seen
🌐Links in this video
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
Pendulum 20% discount with code HEALTHSPAN
Akkermansia https://www.dpbolvw.net/click-100875787-15048681
Glucose Control https://www.tkqlhce.com/click-100875787-15009432
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
We talk to Dr Colleen Cutcliffe about a clinical trial that they ran with 5 strains of probiotic. We also talk about whether the strains remained resident and what are the best prebiotics for akkermansia.
🌐Links in this video
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
Pendulum 20% discount with code HEALTHSPAN
Akkermansia https://www.dpbolvw.net/click-100875787-15048681
Glucose Control https://www.tkqlhce.com/click-100875787-15009432
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com
We talk to Dr Colleen Cutcliffe about akkermansia muciniphila a probiotic that is involved in
Some links are affiliate links so we will earn a commission when they are used to purchase products.
🌐Links in this video
Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
Pendulum 20% discount with code HEALTHSPAN
Akkermansia https://www.dpbolvw.net/click-100875787-15048681
Glucose Control https://www.tkqlhce.com/click-100875787-15009432
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
This is a bonus extra where we asked Dr Baur for his view on the recent taurine longevity paper as he had written a perspective piece in the same publication - Taurine linked with healthy aging https://www.science.org/doi/10.1126/science.adi3025
🌐Links in this video
The Baur Lab website https://www.med.upenn.edu/baurlab/
Catch us on YouTube
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We talk to Dr Joseph Baur about NMNH and NRH and some of the ways that his lab is working on optimizing NAD boosters by trying to get more of the NAD into the mitochondria and testing on larger animals and in humans.
🌐Links in this video
The Baur Lab website https://www.med.upenn.edu/baurlab/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
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We talk to Dr Joseph Baur about how the NAD precursors are absorbed when administered in different formats and what is seen in the biochemistry after that. And some really weird interaction between mammals and bacteria with nicotinamide/nicotinic acid in the gut.
🌐Links in this video
The Baur Lab website https://www.med.upenn.edu/baurlab/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
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We talk to Dr Joseph Baur about results from trials of NAD boosters in mice and human trials and possible reasons for why the positive results in mice have not translated to humans.
🌐Links in this video
The Baur Lab website https://www.med.upenn.edu/baurlab/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
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We talk to Dr Joseph Baur about how NAD metabolism changes with age, especially the role of NAMPT, the consuming enzymes and NAD boosters.
🌐Links in this video
The Baur Lab website https://www.med.upenn.edu/baurlab/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
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We talk to Dr Joseph Baur about the evidence of NAD decline with age and how it can be restored with exercise. We also touch on NAD/NADH ratio.
Some links are affiliate links so we will earn a commission when they are used to purchase products.
🌐Links in this video
The Baur Lab website https://www.med.upenn.edu/baurlab/
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
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We talk to Dr Vijay Yadav about his planned next steps for interventional human trials and what doses he will try.
Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.
🌐Links in this podcast
Dr Yadav on Linkedin https://www.linkedin.com/in/drvijaykyadav
Taurine deficiency as a driver of aging https://www.science.org/doi/10.1126/science.abn9257
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
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We talk to Dr Vijay Yadav about the human results from the trial and how the dosage might translate into humans.
Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.
🌐Links in this podcast
Dr Yadav on Linkedin https://www.linkedin.com/in/drvijaykyadav
Taurine deficiency as a driver of aging https://www.science.org/doi/10.1126/science.abn9257
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
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We talk to Dr Vijay Yadav about some of the results in terms of lifespan and healthspan from the recent paper that he was the main author on.
Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.
🌐Links in this podcast
Dr Yadav on Linkedin https://www.linkedin.com/in/drvijaykyadav
Taurine deficiency as a driver of aging https://www.science.org/doi/10.1126/science.abn9257
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
We talk to Dr Vijay Yadav about taurine, why he started studying it, some of the history and how it varies with age.
Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse genetic (CRISPR/Cas, homologous recombination in embryonic stem cells, iPS cells), genomic (Nucleic acid sequencing), and proteomic (MS/NMR/HPLC). The ultimate aim is to identify novel therapeutic targets for genetic and metabolic disorders to manage these diseases in humans.
🌐Links in this podcast
Dr Yadav on Linkedin https://www.linkedin.com/in/drvijaykyadav
Taurine deficiency as a driver of aging https://www.science.org/doi/10.1126/science.abn9257
Catch us on YouTube: https://www.youtube.com/c/modernhealthspan
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
In this episode Dr Yurth talks about her longevity protocol, including her use of a CGM and protein requirements.
Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute.
Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific research on how to truly heal the body at the cellular level.
🌐 Boulder Longevity Institute https://boulderlongevity.com/
🌐 Human Optimization Academy https://bli.academy/
🌐 Seeds Scientific Research & Performance Institute https://ssrpinstitute.org/
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In this video Dr Yurth introduces spermidine as an autophagy activator and talks about the regimen she uses while focusing on muscle maintenance and growth.
Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute.
Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific research on how to truly heal the body at the cellular level.
🌐 Boulder Longevity Institute https://boulderlongevity.com/
🌐 Human Optimization Academy https://bli.academy/
🌐 Seeds Scientific Research & Performance Institute https://ssrpinstitute.org/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Yurth introduces what peptides are and talks about some of the most important ones for longevity and how they work.
Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute.
Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific research on how to truly heal the body at the cellular level.
🌐 Boulder Longevity Institute https://boulderlongevity.com/
🌐 Human Optimization Academy https://bli.academy/
🌐 Seeds Scientific Research & Performance Institute https://ssrpinstitute.org/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
In this episode Dr Yurth talks about why she set up the Boulder Longevity Institute and the key metrics that she looks for to determine a persons true health
Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute.
Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific research on how to truly heal the body at the cellular level.
🌐 Boulder Longevity Institute https://boulderlongevity.com/
🌐 Human Optimization Academy https://bli.academy/
🌐 Seeds Scientific Research & Performance Institute https://ssrpinstitute.org/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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ProHealth 15% of all products Code MODERN: https://www.prohealth.com/
In this episode Dr Newport talks about some of the do's and don'ts to minimize the risk of getting Alzheimer's. In this video Dr Bohr discusses his experience with NR, NMN and Urolithin A, using NAD boosters in people and the importance of measuring not only NAD but also its metabolites. And the impact of NR supplementation on the gut microbiome.
Dr. Vilhelm Bohr is a molecular biologist who is currently an affiliate professor at the University of Copenhagen. He is also a former chief of the Laboratory of Molecular Genetics at the National Institute on Aging (NIA). Dr. Bohr's research interests focus on DNA repair, mitochondrial biology, and energy metabolism. He is particularly interested in how these processes interact with one another to impact the aging process and age-associated neurodegeneration.
🌐Dr Bohr's lab at University of Copenhagen https://icmm.ku.dk/english/research-groups/bohr-group/
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In this episode Dr Bohr talks about NR's impact on age related loss of hearing and smell in mice
Dr. Vilhelm Bohr is a molecular biologist who is currently an affiliate professor at the University of Copenhagen. He is also a former chief of the Laboratory of Molecular Genetics at the National Institute on Aging (NIA). Dr. Bohr's research interests focus on DNA repair, mitochondrial biology, and energy metabolism. He is particularly interested in how these processes interact with one another to impact the aging process and age-associated neurodegeneration.
🌐Dr Bohr's lab at University of Copenhagen https://icmm.ku.dk/english/research-groups/bohr-group/
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In this episode Dr Bohr talks about his work with Alzheimer's using Nicotinamide Riboside (NR) and how this impacts DNA repair, mitophagy, senescence and inflammation.
Dr. Vilhelm Bohr is a molecular biologist who is currently an affiliate professor at the University of Copenhagen. He is also a former chief of the Laboratory of Molecular Genetics at the National Institute on Aging (NIA). Dr. Bohr's research interests focus on DNA repair, mitochondrial biology, and energy metabolism. He is particularly interested in how these processes interact with one another to impact the aging process and age-associated neurodegeneration.
🌐Dr Bohr's lab at University of Copenhagen https://icmm.ku.dk/english/research-groups/bohr-group/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
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In this episode Dr Bohr talks about mitochondria, how they change with age and the importance of mitophagy.
Dr. Vilhelm Bohr is a molecular biologist who is currently an affiliate professor at the University of Copenhagen. He is also a former chief of the Laboratory of Molecular Genetics at the National Institute on Aging (NIA). Dr. Bohr's research interests focus on DNA repair, mitochondrial biology, and energy metabolism. He is particularly interested in how these processes interact with one another to impact the aging process and age-associated neurodegeneration.
🌐Dr Bohr's lab at University of Copenhagen https://icmm.ku.dk/english/research-groups/bohr-group/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Newport talks about some of the trials which are using MCT and ketogenic diets to address mild cognitive impairment and Parkinson's.
Dr Newport's web page
https://coconutketones.com/
Mary T. Newport, M.D. became a messenger in 2008 when she found a nutritional intervention that supplied ketones as alternative fuel for the brain for her husband Steve Newport with early-onset Alzheimer’s disease. Steve responded dramatically to consuming medium-chain triglycerides (MCTs) from coconut oil which produce ketones when consumed. Two years later he improved again in a pilot study of one person consuming the Veech ketone ester…this ester added twenty more months of stability. Together these solutions gave him nearly four more better-quality years.
Dr Newport practiced neonatology in Florida for 30 years and served as founding medical director for two newborn intensive care units in the Tampa Bay area. After taking some time off to care for Steve, she resumed medical practice at the opposite end of the spectrum and now makes home visits with people who have chronic conditions. She is author of four books and an international speaker on the subject of ketones as an alternative fuel for the brain.
Dr. Newport is a Certified Ketogenic Nutrition Specialist (CKNS) since September 2019 through a program offered by the American Nutrition Association.
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Hi All, my sincere apologies for the repeat posting of episode 4 as episode 5. I have now deleted that version. This the correct version but has an advert in it that is intended for the video edition only. At this point is difficult to remove the advert.
In this video Dr Newport talks about some supplements to take and some to be careful about. And also the benefits seen with ketone esters and ketone salts in clinical trials.
Dr Newport's web page
https://coconutketones.com/
Mary T. Newport, M.D. became a messenger in 2008 when she found a nutritional intervention that supplied ketones as alternative fuel for the brain for her husband Steve Newport with early-onset Alzheimer’s disease. Steve responded dramatically to consuming medium-chain triglycerides (MCTs) from coconut oil which produce ketones when consumed. Two years later he improved again in a pilot study of one person consuming the Veech ketone ester…this ester added twenty more months of stability. Together these solutions gave him nearly four more better-quality years.
Dr Newport practiced neonatology in Florida for 30 years and served as founding medical director for two newborn intensive care units in the Tampa Bay area. After taking some time off to care for Steve, she resumed medical practice at the opposite end of the spectrum and now makes home visits with people who have chronic conditions. She is author of four books and an international speaker on the subject of ketones as an alternative fuel for the brain.
Dr. Newport is a Certified Ketogenic Nutrition Specialist (CKNS) since September 2019 through a program offered by the American Nutrition Association.
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Newport talks about some supplements to take and some to be careful about. And also the benefits seen with ketone esters and ketone salts in clinical trials.
Dr Newport's web page
https://coconutketones.com/
Mary T. Newport, M.D. became a messenger in 2008 when she found a nutritional intervention that supplied ketones as alternative fuel for the brain for her husband Steve Newport with early-onset Alzheimer’s disease. Steve responded dramatically to consuming medium-chain triglycerides (MCTs) from coconut oil which produce ketones when consumed. Two years later he improved again in a pilot study of one person consuming the Veech ketone ester…this ester added twenty more months of stability. Together these solutions gave him nearly four more better-quality years.
Dr Newport practiced neonatology in Florida for 30 years and served as founding medical director for two newborn intensive care units in the Tampa Bay area. After taking some time off to care for Steve, she resumed medical practice at the opposite end of the spectrum and now makes home visits with people who have chronic conditions. She is author of four books and an international speaker on the subject of ketones as an alternative fuel for the brain.
Dr. Newport is a Certified Ketogenic Nutrition Specialist (CKNS) since September 2019 through a program offered by the American Nutrition Association.
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this episode Dr Newport talks about some of the do's and don'ts to minimize the risk of getting Alzheimer's.
Dr Newport's web page
https://coconutketones.com/
Mary T. Newport, M.D. became a messenger in 2008 when she found a nutritional intervention that supplied ketones as alternative fuel for the brain for her husband Steve Newport with early-onset Alzheimer’s disease. Steve responded dramatically to consuming medium-chain triglycerides (MCTs) from coconut oil which produce ketones when consumed. Two years later he improved again in a pilot study of one person consuming the Veech ketone ester…this ester added twenty more months of stability. Together these solutions gave him nearly four more better-quality years.
Dr Newport practiced neonatology in Florida for 30 years and served as founding medical director for two newborn intensive care units in the Tampa Bay area. After taking some time off to care for Steve, she resumed medical practice at the opposite end of the spectrum and now makes home visits with people who have chronic conditions. She is author of four books and an international speaker on the subject of ketones as an alternative fuel for the brain.
Dr. Newport is a Certified Ketogenic Nutrition Specialist (CKNS) since September 2019 through a program offered by the American Nutrition Association.
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MHS https://donotage.org/products/
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
Our brain needs fuel all the time, including when we sleep. In the case it is insulin resistant there need to be ketones always available. In this video Dr Newport talks about how to maintain ketones in your blood and some of the benefits of a low carbohydrate diet.
Dr Newport's web page
https://coconutketones.com/
Mary T. Newport, M.D. became a messenger in 2008 when she found a nutritional intervention that supplied ketones as alternative fuel for the brain for her husband Steve Newport with early-onset Alzheimer’s disease. Steve responded dramatically to consuming medium-chain triglycerides (MCTs) from coconut oil which produce ketones when consumed. Two years later he improved again in a pilot study of one person consuming the Veech ketone ester…this ester added twenty more months of stability. Together these solutions gave him nearly four more better-quality years.
Dr Newport practiced neonatology in Florida for 30 years and served as founding medical director for two newborn intensive care units in the Tampa Bay area. After taking some time off to care for Steve, she resumed medical practice at the opposite end of the spectrum and now makes home visits with people who have chronic conditions. She is author of four books and an international speaker on the subject of ketones as an alternative fuel for the brain.
Dr. Newport is a Certified Ketogenic Nutrition Specialist (CKNS) since September 2019 through a program offered by the American Nutrition Association.
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Newport talks about why she uses both MCT as well as coconut and the advantages of lauric acid (C:12) one of the main constituents of coconut oil.
Dr Newport's web page
https://coconutketones.com/
Mary T. Newport, M.D. became a messenger in 2008 when she found a nutritional intervention that supplied ketones as alternative fuel for the brain for her husband Steve Newport with early-onset Alzheimer’s disease. Steve responded dramatically to consuming medium-chain triglycerides (MCTs) from coconut oil which produce ketones when consumed. Two years later he improved again in a pilot study of one person consuming the Veech ketone ester…this ester added twenty more months of stability. Together these solutions gave him nearly four more better-quality years.
Dr Newport practiced neonatology in Florida for 30 years and served as founding medical director for two newborn intensive care units in the Tampa Bay area. After taking some time off to care for Steve, she resumed medical practice at the opposite end of the spectrum and now makes home visits with people who have chronic conditions. She is author of four books and an international speaker on the subject of ketones as an alternative fuel for the brain.
Dr. Newport is a Certified Ketogenic Nutrition Specialist (CKNS) since September 2019 through a program offered by the American Nutrition Association.
In this video Dr Newport tells the story of her husband's experience with Alzheimer's and how a ketogenic diet supplemented with coconut and MCT oil improved his condition.
Dr Newport's web page
https://coconutketones.com/
Mary T. Newport, M.D. became a messenger in 2008 when she found a nutritional intervention that supplied ketones as alternative fuel for the brain for her husband Steve Newport with early-onset Alzheimer’s disease. Steve responded dramatically to consuming medium-chain triglycerides (MCTs) from coconut oil which produce ketones when consumed. Two years later he improved again in a pilot study of one person consuming the Veech ketone ester…this ester added twenty more months of stability. Together these solutions gave him nearly four more better-quality years.
Dr Newport practiced neonatology in Florida for 30 years and served as founding medical director for two newborn intensive care units in the Tampa Bay area. After taking some time off to care for Steve, she resumed medical practice at the opposite end of the spectrum and now makes home visits with people who have chronic conditions. She is author of four books and an international speaker on the subject of ketones as an alternative fuel for the brain.
Dr. Newport is a Certified Ketogenic Nutrition Specialist (CKNS) since September 2019 through a program offered by the American Nutrition Association.
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Kaufmann about her thinking on supplements, as well as looking at COVID, autoimmune diseases, eye aging. We also discuss some other therapies, including stem cells, exosomes, DNA infusion and plasmapheresis.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of two books, The Kaufmann Protocol: Why We Age and How to Stop It and her new book, The Kaufmann Protocol: Aging Solutions. In the books she describes the mechanisms of aging on a cellular level and provides details on many of the supplements that we can use to slow it down.
🌐Dr Kaufmann's web site _https://kaufmannprotocol.com/_
📚Dr Kaufmann's books on Amazon
The Kaufmann Protocol: Aging Solutions _https://amzn.to/3Typ41x_
The Kaufmann Protocol: Why we Age and How to Stop it _https://amzn.to/3yWnEEo_
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Kaufmann talks about preserving the skin, a very important topic for her as she is a rock climber and spends a fair amount of time outside at high altitudes!
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of two books, The Kaufmann Protocol: Why We Age and How to Stop It and her new book, The Kaufmann Protocol: Aging Solutions. In the books she describes the mechanisms of aging on a cellular level and provides details on many of the supplements that we can use to slow it down.
🌐Dr Kaufmann's web site _https://kaufmannprotocol.com/_
📚Dr Kaufmann's books on Amazon
The Kaufmann Protocol: Aging Solutions _https://amzn.to/3Typ41x_
The Kaufmann Protocol: Why we Age and How to Stop it _https://amzn.to/3yWnEEo_
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Kaufmann introduces talks about mitochondria and keeping them healthy and also maintaining muscle. We also touch on blood glucose levels and natural SGL2 inhibitors.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of two books, The Kaufmann Protocol: Why We Age and How to Stop It and her new book, The Kaufmann Protocol: Aging Solutions. In the books she describes the mechanisms of aging on a cellular level and provides details on many of the supplements that we can use to slow it down.
🌐Dr Kaufmann's web site _https://kaufmannprotocol.com/_
📚Dr Kaufmann's books on Amazon
The Kaufmann Protocol: Aging Solutions _https://amzn.to/3Typ41x_
The Kaufmann Protocol: Why we Age and How to Stop it _https://amzn.to/3yWnEEo_
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Kaufmann introduces the Kaufmann Protocol and the method behind how she constructed it. She also talks about the rating system for that she uses for the supplements.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of two books, The Kaufmann Protocol: Why We Age and How to Stop It and her new book, The Kaufmann Protocol: Aging Solutions. In the books she describes the mechanisms of aging on a cellular level and provides details on many of the supplements that we can use to slow it down.
🌐Dr Kaufmann's web site _https://kaufmannprotocol.com/_
📚Dr Kaufmann's books on Amazon
The Kaufmann Protocol: Aging Solutions _https://amzn.to/3Typ41x_
The Kaufmann Protocol: Why we Age and How to Stop it _https://amzn.to/3yWnEEo_
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for subscriptions
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Harris talks about how omega-3's impact eye and brain health. He also talks about the Fatty Acid Research Institute that he set up and the work they are doing.
Dr. Bill Harris has been a leading researcher in the omega-3 fatty acid field for 40 years. He has over 300 scientific papers on fatty acids and health, the vast majority on omega-3. He has been on the faculty of three medical schools (Universities of Kansas, Missouri (at Kansas City), and South Dakota), and has received 5 NIH grants to study omega-3. He was the co-author on three AHA statements on fatty acids and heart health. As the co-inventor of the Omega-3 Index (and other omega-3 blood tests) and founder of OmegaQuant Analytics, Dr. Harris has been ranked among the top 2% of scientists worldwide based on the impact of his research.
🌐The Fatty Acid Research Institute _https://www.faresinst.org/_
🌐Omegaquant _https://omegaquant.com/_
5% off OmegaQuant test for Omega-3 index, _https://omegaquant.com/ref/500/_ code SNNNMKJHVL
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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In this video Dr Harris talks about his recent review paper looking a the omega-3 index and all cause mortality and the omega-3's impact on heart health.
Dr. Bill Harris has been a leading researcher in the omega-3 fatty acid field for 40 years. He has over 300 scientific papers on fatty acids and health, the vast majority on omega-3. He has been on the faculty of three medical schools (Universities of Kansas, Missouri (at Kansas City), and South Dakota), and has received 5 NIH grants to study omega-3. He was the co-author on three AHA statements on fatty acids and heart health. As the co-inventor of the Omega-3 Index (and other omega-3 blood tests) and founder of OmegaQuant Analytics, Dr. Harris has been ranked among the top 2% of scientists worldwide based on the impact of his research.
🌐The Fatty Acid Research Institute _https://www.faresinst.org/_
🌐Omegaquant _https://omegaquant.com/_
5% off OmegaQuant test for Omega-3 index, _https://omegaquant.com/ref/500/_ code SNNNMKJHVL
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
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ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this episode Dr Harris talks about where to get omega-3 from in your diet. Also supplements, how much and when to take. He also introduces the omega-3 index calculator.
Dr. Bill Harris has been a leading researcher in the omega-3 fatty acid field for 40 years. He has over 300 scientific papers on fatty acids and health, the vast majority on omega-3. He has been on the faculty of three medical schools (Universities of Kansas, Missouri (at Kansas City), and South Dakota), and has received 5 NIH grants to study omega-3. He was the co-author on three AHA statements on fatty acids and heart health. As the co-inventor of the Omega-3 Index (and other omega-3 blood tests) and founder of OmegaQuant Analytics, Dr. Harris has been ranked among the top 2% of scientists worldwide based on the impact of his research.
🌐The Fatty Acid Research Institute _https://www.faresinst.org/_
🌐Omegaquant _https://omegaquant.com/_
5% off OmegaQuant test for Omega-3 index, _https://omegaquant.com/ref/500/_ code SNNNMKJHVL
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
Use SUBMHS for subscriptions
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Harris talks about the omega-3 introduces the omega-3 index and explains what it is. We also talk about its impact on RDW, red blood cell distribution width, which is a component of the PhenoAge calculation
Dr. Bill Harris has been a leading researcher in the omega-3 fatty acid field for 40 years. He has over 300 scientific papers on fatty acids and health, the vast majority on omega-3. He has been on the faculty of three medical schools (Universities of Kansas, Missouri (at Kansas City), and South Dakota), and has received 5 NIH grants to study omega-3. He was the co-author on three AHA statements on fatty acids and heart health. As the co-inventor of the Omega-3 Index (and other omega-3 blood tests) and founder of OmegaQuant Analytics, Dr. Harris has been ranked among the top 2% of scientists worldwide based on the impact of his research.
🌐The Fatty Acid Research Institute _https://www.faresinst.org/_
🌐Omegaquant _https://omegaquant.com/_
5% off OmegaQuant test for Omega-3 index, _https://omegaquant.com/ref/500/_ code SNNNMKJHVL
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
Use SUBMHS for subscriptions
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Dr Harris introduces the various types of fats and then goes into more detail on essential omega-3 fatty acids. He also discusses omega-6 fatty acids and whether they are positive for health or not.
Dr. Bill Harris has been a leading researcher in the omega-3 fatty acid field for 40 years. He has over 300 scientific papers on fatty acids and health, the vast majority on omega-3. He has been on the faculty of three medical schools (Universities of Kansas, Missouri (at Kansas City), and South Dakota), and has received 5 NIH grants to study omega-3. He was the co-author on three AHA statements on fatty acids and heart health. As the co-inventor of the Omega-3 Index (and other omega-3 blood tests) and founder of OmegaQuant Analytics, Dr. Harris has been ranked among the top 2% of scientists worldwide based on the impact of his research.
🌐The Fatty Acid Research Institute _https://www.faresinst.org/_
🌐Omegaquant _https://omegaquant.com/_
5% off OmegaQuant test for Omega-3 index, _https://omegaquant.com/ref/500/_ code SNNNMKJHVL
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
Use SUBMHS for subscriptions
ProHealth 10% of all products Code MODERN: https://www.prohealth.com/
In this video Professor Zemel discusses what he sees as the most promising areas of investigation in healthspan as well as his own health protocol.
COSMOS Trial web page https://cosmostrial.org/
Dr Michael Zemel is Professor Emeritus at the University of Tennessee and the founder and chief scientific officer at NuSirt, a company developing solutions to treat chronic diseases of aging and over nutrition. In his 40 years of academic research he has authored more than 200 peer reviewed publications.
🌐NuSirt Biopharma web site https://nusirt.com/
Some links are affiliate links so we will earn a commission when they are used to purchase products.
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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In this video Professor Zemel discusses OS200 the regulated therapy that NuSirt is currently in human trials with for obesity, NAFLD and pre-diabetes. The therapy includes leucine, metformin and sildenafil.
Dr Michael Zemel is Professor Emeritus at the University of Tennessee and the founder and chief scientific officer at NuSirt, a company developing solutions to treat chronic diseases of aging and over nutrition. In his 40 years of academic research he has authored more than 200 peer reviewed publications.
🌐NuSirt Biopharma web site https://nusirt.com/
Some links are affiliate links so we will earn a commission when they are used to purchase products.
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
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In this video Professor Zemel discusses human trials of leucine with B6 and why they tested that combination. These human trials then led to trials in companion dogs, which is a strange twist. And finally he shares his thoughts on the nutraceutical market.
Dr Michael Zemel is Professor Emeritus at the University of Tennessee and the founder and chief scientific officer at NuSirt, a company developing solutions to treat chronic diseases of aging and over nutrition. In his 40 years of academic research he has authored more than 200 peer reviewed publications.
🌐NuSirt Biopharma web site https://nusirt.com/
Some links are affiliate links so we will earn a commission when they are used to purchase products.
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
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In this video Professor Zemel introduces his research on leucine and why it is so special. He then talks about how it helps to amplify the effects of resveratrol and NAD precursors.
Dr Michael Zemel is Professor Emeritus at the University of Tennessee and the founder and chief scientific officer at NuSirt, a company developing solutions to treat chronic diseases of aging and over nutrition. In his 40 years of academic research he has authored more than 200 peer reviewed publications.
🌐NuSirt Biopharma web site https://nusirt.com/
Some links are affiliate links so we will earn a commission when they are used to purchase products.
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
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In this video Dr Guttuso talks about his experience with lithium and long COVID and the clinical trial that he has started to study this further. He also shares his personal health protocol.
Thomas Guttuso, Jr., MD, is a professor of neurology at the University at Buffalo. He has been treating patients with Parkinson’s for over twenty years and has published over thirty articles in leading medical journals. Dr Guttuso recently published the book “The Promise Of Lithium” on the use of lithium supplementation to potentially slow the progression of both Alzheimer’s and Parkinson’s. He is also currently conducting a placebo-controlled trial in examining the effects of low-dose lithium therapy on long COVID symptoms.
📖 The Promise of Lithium book https://amzn.to/3HSCP5R
🌐 Website for the book: https://www.promiseoflithium.com/
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In this video Dr Guttuso talks using lithium as a supplement and the different formulations (carbonate, orotate and aspartate), the dosage, safety profile and possible interaction with other medications.
Thomas Guttuso, Jr., MD, is a professor of neurology at the University at Buffalo. He has been treating patients with Parkinson’s for over twenty years and has published over thirty articles in leading medical journals. Dr Guttuso recently published the book “The Promise Of Lithium” on the use of lithium supplementation to potentially slow the progression of both Alzheimer’s and Parkinson’s. He is also currently conducting a placebo-controlled trial in examining the effects of low-dose lithium therapy on long COVID symptoms.
📖 The Promise of Lithium book _https://amzn.to/3HSCP5R_
🌐 Website for the book: _https://www.promiseoflithium.com/_
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
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ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Guttuso talks about two positive random controlled clinical trials of low dose lithium with Alzheimer's and two on going trials.
Thomas Guttuso, Jr., MD, is a professor of neurology at the University at Buffalo. He has been treating patients with Parkinson’s for over twenty years and has published over thirty articles in leading medical journals. Dr Guttuso recently published the book “The Promise Of Lithium” on the use of lithium supplementation to potentially slow the progression of both Alzheimer’s and Parkinson’s. He is also currently conducting a placebo-controlled trial in examining the effects of low-dose lithium therapy on long COVID symptoms.
📖 The Promise of Lithium book _https://amzn.to/3HSCP5R_
🌐 Website for the book: _https://www.promiseoflithium.com/_
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
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ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Guttuso shares some of his background, how he identified lithium as a potential supplement to slow or prevent Alzheimer's and Parkinson's and the observational data supporting this.
Thomas Guttuso, Jr., MD, is a professor of neurology at the University at Buffalo. He has been treating patients with Parkinson’s for over twenty years and has published over thirty articles in leading medical journals. Dr Guttuso recently published the book “The Promise Of Lithium” on the use of lithium supplementation to potentially slow the progression of both Alzheimer’s and Parkinson’s. He is also currently conducting a placebo-controlled trial in examining the effects of low-dose lithium therapy on long COVID symptoms.
📖 The Promise of Lithium book _https://amzn.to/3HSCP5R_
🌐 Website for the book: _https://www.promiseoflithium.com/_
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Professor Sebastiano discusses the future for partial reprogramming and other longevity technologies that he sees as the most promising.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnow5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
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In this video Professor Sebastiano discusses how the timing of the therapy might work, concerns of whether the "point of no return" might be crossed and what aspects of aging are not covered by partial cellular reprogramming.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnew5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
15% Discount on Renue By Science with Code MHS15 until May 01 2023
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Professor Sebastiano discusses the three most advanced interventions that Turn Bio is working on, for skin, immunology and muscles and when they will be available for human trial.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnew5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
15% Discount on Renue By Science with Code MHS15 until May 01 2023
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Professor Sebastiano discusses the results that he and his team have had in rejuvenating human cells and how the process could be applied as well as their experience rejuvenating a muscle in an old mouse.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERNnew5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
15% Discount on Renue By Science with Code MHS15 until May 01 2023
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Professor Sebastiano discusses the results that he and his team have had in rejuvenating human cells and how the process could be applied as well as their experience rejuvenating a muscle in an old mouse.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
15% Discount on Renue By Science with Code MHS15 until May 01 2023
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this video Professor Sebastiano discusses how the mRNA is delivered to the specific cells and how the recent explosion of mRNA interest has changed the development landscape.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
15% Discount on Renue By Science with Code MHS15 until May 01 2023
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Professor Sebastiano introduces ERA, Epigenetic Reprogramming of Age technology and talks about his thoughts on some of the causes of aging
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website
https://www.turn.bio/
Professor Sebastiano's lab at Stanford
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
https://pubmed.ncbi.nlm.nih.gov/32210226/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
15% Discount on Renue By Science with Code MHS15 until May 01 2023
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Newman talks about ketones as a fuel for the brain and how this becomes more important as we age and the brain can become less able to use glucose.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.
Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
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In this episode Dr Newman talks the ITP lifespan trials that used butanediol but did not see a significant result. He covers what might have caused this and some of the chemistry behind butanediol and butyrate.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.
Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Newman talks ways of boosting ketones through ketone supplements, what the different types are and what has been seen with them in human trials.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.
Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Newman talks about experiments that he and other teams have run on mice lifespan and healthspan while they were on ketogenic diets.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.
Dr Newman's lab at the BuckInstitute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California,San Francisco.
https://medicine.ucsf.edu/people/john-newman
NOVOS Core & NOVOS Boosthttps://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products withdiscount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Scienceproducts with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Newman discusses ketones and their impact on aging.
Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.
Dr Newman's lab at the Buck Institute
https://www.buckinstitute.org/lab/newman-lab/
And at University of California, San Francisco.
https://medicine.ucsf.edu/people/john-newman
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Davidsohn discusses the next generation therapies that Rejuvenate Bio are working on. We also discuss, klotho, RJB02 and his personal protocol.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Davidsohn discusses taking RJB01 to trial with humans for a rare heart disease and how gene therapy is viewed by the FDA.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Davidsohn discusses how the gene therapy helps with heart health and is only required one time.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Davidsohn talks about the first therapy Rejuvenate Bio is working on which restores a more youthful protein expression in the liver which then impacts the rest of the body.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode we discuss some of Dr Davidsohn's background, the mission of Rejuvenate Bio and the gene therapy that was developed at Dr Church's lab and is now being used to treat companion dogs.
Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases.
Rejuvenate Bio website
https://www.rejuvenatebio.com/
Dr Davidsohn's paper mentioned in the interview
A single combination gene therapy treats multiple age-related diseases
https://pubmed.ncbi.nlm.nih.gov/31685628/
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Verburgh talks about his personal longevity protocol.
Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases
And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Verburgh talks about his theory of aging and why he thinks that epigenetic dysregulation is the most fundamental of the hall marks.
Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases
And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Verburgh talks about his thoughts on the escape velocity of aging and what it might mean for humanity.
Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases
And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Verburgh talks about developments in using mobile phones as a diagnostic device.
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Verburgh talks about some of the upcoming technologies which will impact the longevity space in the coming years, including improvements in gene editing and epigenetics.
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
ProHealth 10% of all products Code MODERN : https://www.prohealth.com/
In this episode Dr Verburgh talks about how to optimise our micronutrient intake. This is not simple as it is sometimes difficult to know whether you have sufficient of certain micronutrients just by looking at the blood.
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
In this episode Dr Verburgh talks what are the key elements of a longevity diet. Dr Verburgh first wrote a paper on this subject in 2015, which introduced the term Nutrigerontology.
The paper is: Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases
And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
In this episode Dr Verburgh talks about his three (well, he cheats a bit and squeezes in 5!) supplements for aging.
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
In this episode Dr Verburgh talks about the founding of NOVOS and why NMN was their choice for the NAD booster
Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head of science at the Longevity Vision Fund. With that let me start the interview.
Dr Verburgh's home page
http://www.krisverburgh.com/
At The Singularity University
https://www.su.org/experts/kris-verburgh
Dr Verburgh's books on Amazon
The Longevity Code
https://amzn.to/3APpHuy
The Food Hourglass
https://amzn.to/3KJsKJc
NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5
10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/
10% Discount on Renue By Science products with code MHS https://renuebyscience.com/
In this episode Dr Naiman talks about the three forms of exercise, walking, resistance and cardio, trading intensity for duration and the importance of VO2max.
Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices.
Dr Naiman's personal site
https://tednaiman.com/
The Protein Percent calculator
https://www.proteinpercent.com/
Ted Naiman at the Diet Doctor
https://www.dietdoctor.com/authors/dr-ted-naiman-md
The rest of the interview can be found at Dr Naiman's playlist. https://tinyurl.com/5n7jxmc8
The PE Diet: Leverage your biology to achieve optimal health on Amazon https://amzn.to/3QgDm4u
In this episode Dr Naiman talks about metabolic health and how it is the same thing as body composition and what we can do to have the best metabolic health.
Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices.
Dr Naiman's personal site
https://tednaiman.com/
The Protein Percent calculator
https://www.proteinpercent.com/
Ted Naiman at the Diet Doctor
https://www.dietdoctor.com/authors/dr-ted-naiman-md
The rest of the interview can be found at Dr Naiman's playlist. https://tinyurl.com/5n7jxmc8
The PE Diet: Leverage your biology to achieve optimal health on Amazon https://amzn.to/3QgDm4u
Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices.
Dr Naiman's personal site
https://tednaiman.com/
The Protein Percent calculator
https://www.proteinpercent.com/
Ted Naiman at the Diet Doctor
https://www.dietdoctor.com/authors/dr-ted-naiman-md
The rest of the interview can be found at Dr Naiman's playlist. https://tinyurl.com/5n7jxmc8
The PE Diet: Leverage your biology to achieve optimal health on Amazon https://amzn.to/3QgDm4u
In this episode Dr Naiman talks how protein is absorbed into the body, what would be a good eating pattern and the difference between plant and animal proteins.
Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices.
Dr Naiman's personal site
https://tednaiman.com/
The Protein Percent calculator
https://www.proteinpercent.com/
Ted Naiman at the Diet Doctor
https://www.dietdoctor.com/authors/dr-ted-naiman-md
The rest of the interview can be found at Dr Naiman's playlist. https://tinyurl.com/5n7jxmc8
The PE Diet: Leverage your biology to achieve optimal health on Amazon https://amzn.to/3QgDm4u
In this episode Dr Naiman talks about how mTOR is activated and why our metabolic health is of much greater importance than the amount of protein that we eat.
Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices.
Dr Naiman's personal site
https://tednaiman.com/
The Protein Percent calculator
https://www.proteinpercent.com/
Ted Naiman at the Diet Doctor
https://www.dietdoctor.com/authors/dr-ted-naiman-md
The rest of the interview can be found at Dr Naiman's playlist. https://tinyurl.com/5n7jxmc8
The PE Diet: Leverage your biology to achieve optimal health on Amazon https://amzn.to/3QgDm4u
In this episode Dr Naiman provides a more practical view on the PE Diet. What P:E ratio we should aim for, what is an optimal protein intake and how to find the P:E ratio for various foods.
Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices.
Dr Naiman's personal site
https://tednaiman.com/
The Protein Percent calculator
https://www.proteinpercent.com/
Ted Naiman at the Diet Doctor
https://www.dietdoctor.com/authors/dr-ted-naiman-md
The rest of the interview can be found at Dr Naiman's playlist. https://tinyurl.com/5n7jxmc8
The PE Diet: Leverage your biology to achieve optimal health on Amazon https://amzn.to/3QgDm4u
In this episode Dr Naiman talks about his personal journey through various diets to his formulation of the PE Diet.
Dr Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food and exercise choices.
Dr Naiman's personal site
https://tednaiman.com/
The Protein Percent calculator
https://www.proteinpercent.com/
Ted Naiman at the Diet Doctor
https://www.dietdoctor.com/authors/dr-ted-naiman-md
In this episode Dr Cohen talks about the current interventions that he sees as having the most potential but also about the need for precision medicine as there are many causes for Alzheimer's, diabetes etc. and to treat the disease we need to understand the underlying cause. This also would involve changes in the way trials are run, to be able to identify the markers appropriate for each intervention
Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE
https://www.nature.com/articles/s41380-022-01769-3
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen's page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
In this video Dr Cohen talks CohBar, a company that he co-founded with Professor Nir Barzilai and some of the work they are doing, as well as the latest developments in his lab. He also discusses the need for precision medicine in addressing diseases of aging.
Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE
https://www.nature.com/articles/s41380-022-01769-3
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen's page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
In this video Dr Cohen talks about how mitochondria age and how they are not all the same but different in each tissue.
Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE
https://www.nature.com/articles/s41380-022-01769-3
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen's page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
In this episode Dr Cohen talks about humanin, SHLEP2 and MTOS-c, how these impact our health, how this varies with ethnicity and age.
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen's page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
In this episode Dr Cohen talks about SHMOOZE a new MDP that his lab has discovered and recently published a paper on. He also discusses SNPs, mutations in the MOTS-c and Humanin genome which impacts their peptides with knock on effects on diabetes and cognitive decline.
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen's page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
In this episode Dr Cohen talks about mitochondria, the discovery of the peptides they create and some of the benefits that they provide. It seems that the micro-proteins are also not only restricted to the mitochondria and are also made in the nucleus.
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen's page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
In this episode Dr Cohen talks about why he started studying aging, his views on IGF-1 and his theory of why we age.
Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which remains the focus of his current research.
Mitochondria-derived peptides in aging and healthspan
https://pubmed.ncbi.nlm.nih.gov/35499074/
Dr Cohen's page at USC
https://gero.usc.edu/faculty/cohen/
The Cohen Lab
https://gero.usc.edu/labs/cohenlab/
CohBar Inc. Web site
https://www.cohbar.com/
In this episode Dr Katz talk about how the quality of our food has changed in the past and how the concerns of the younger generation may impact it in the future.
Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview.
Dr Katz's home page
https://davidkatzmd.com/
Diet ID
https://www.dietid.com/
Dr Catherine Katz food site
https://cuisinicity.com/
Find Dr Katz's books on Amazon
How To Eat: All Your Food and Diet Questions Answered
https://amzn.to/3TiNbkd
The Truth About Food
https://amzn.to/3ARckLz
The Way to Eat: A Six-Step Path to Lifelong Weight Control
https://amzn.to/3QT2m27
Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent
https://amzn.to/3pQV96w
Papers referred to in this series
Actual Causes of Death in the United States
https://jamanetwork.com/journals/jama/article-abstract/409171
Actual Causes of Death in the United States, 2000
https://jamanetwork.com/journals/jama/article-abstract/198357
The Global Burden of Disease - Lancet web page
https://www.thelancet.com/gbd
In this episode Dr Katz talks the company has formed and the tool that it has created with the aim of providing a quick and easy way to measure your diet quality and find steps to improve it.
Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview.
Dr Katz's home page
https://davidkatzmd.com/
Diet ID
https://www.dietid.com/
Dr Catherine Katz food site
https://cuisinicity.com/
Find Dr Katz's books on Amazon
How To Eat: All Your Food and Diet Questions Answered
https://amzn.to/3TiNbkd
The Truth About Food
https://amzn.to/3ARckLz
The Way to Eat: A Six-Step Path to Lifelong Weight Control
https://amzn.to/3QT2m27
Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent
https://amzn.to/3pQV96w
Papers referred to in this series
Actual Causes of Death in the United States
https://jamanetwork.com/journals/jama/article-abstract/409171
Actual Causes of Death in the United States, 2000
https://jamanetwork.com/journals/jama/article-abstract/198357
The Global Burden of Disease - Lancet web page
https://www.thelancet.com/gbd
In this episode Dr Katz talks about his personal protocol for longevity and the reasons that he follows it.
Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview.
Dr Katz's home page
https://davidkatzmd.com/
Diet ID
https://www.dietid.com/
Dr Catherine Katz food site
https://cuisinicity.com/
Find Dr Katz's books on Amazon
How To Eat: All Your Food and Diet Questions Answered
https://amzn.to/3TiNbkd
The Truth About Food
https://amzn.to/3ARckLz
The Way to Eat: A Six-Step Path to Lifelong Weight Control
https://amzn.to/3QT2m27
Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent
https://amzn.to/3pQV96w
Papers referred to in this series
Actual Causes of Death in the United States
https://jamanetwork.com/journals/jama/article-abstract/409171
Actual Causes of Death in the United States, 2000
https://jamanetwork.com/journals/jama/article-abstract/198357
The Global Burden of Disease - Lancet web page
https://www.thelancet.com/gbd
In this episode Dr Katz talks about whether, even with a healthy whole food diet, we should also include supplements and what those should be.
Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview.
Dr Katz's home page
https://davidkatzmd.com/
Diet ID
https://www.dietid.com/
Dr Catherine Katz food site
https://cuisinicity.com/
Find Dr Katz's books on Amazon
How To Eat: All Your Food and Diet Questions Answered
https://amzn.to/3TiNbkd
The Truth About Food
https://amzn.to/3ARckLz
The Way to Eat: A Six-Step Path to Lifelong Weight Control
https://amzn.to/3QT2m27
Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent
https://amzn.to/3pQV96w
Papers referred to in this series
Actual Causes of Death in the United States
https://jamanetwork.com/journals/jama/article-abstract/409171
Actual Causes of Death in the United States, 2000
https://jamanetwork.com/journals/jama/article-abstract/198357
The Global Burden of Disease - Lancet web page
https://www.thelancet.com/gbd
Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview.
Dr Katz's home page
https://davidkatzmd.com/
Diet ID
https://www.dietid.com/
Dr Catherine Katz food site
https://cuisinicity.com/
Find Dr Katz's books on Amazon
How To Eat: All Your Food and Diet Questions Answered
https://amzn.to/3TiNbkd
The Truth About Food
https://amzn.to/3ARckLz
The Way to Eat: A Six-Step Path to Lifelong Weight Control
https://amzn.to/3QT2m27
Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent
https://amzn.to/3pQV96w
Papers referred to in this series
Actual Causes of Death in the United States
https://jamanetwork.com/journals/jama/article-abstract/409171
Actual Causes of Death in the United States, 2000
https://jamanetwork.com/journals/jama/article-abstract/198357
The Global Burden of Disease - Lancet web page
https://www.thelancet.com/gbd
In this episode Dr Katz talks a specific study comparing a Mediterranean to a keto diet and also discusses diet study design and why so many are pre-decided. We also talk about calorie restriction and intermittent fasting.
Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview.
Dr Katz's home page
https://davidkatzmd.com/
Diet ID
https://www.dietid.com/
Dr Catherine Katz food site
https://cuisinicity.com/
Find Dr Katz's books on Amazon
How To Eat: All Your Food and Diet Questions Answered
https://amzn.to/3TiNbkd
The Truth About Food
https://amzn.to/3ARckLz
The Way to Eat: A Six-Step Path to Lifelong Weight Control
https://amzn.to/3QT2m27
Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent
https://amzn.to/3pQV96w
Papers referred to in this series
Actual Causes of Death in the United States
https://jamanetwork.com/journals/jama/article-abstract/409171
Actual Causes of Death in the United States, 2000
https://jamanetwork.com/journals/jama/article-abstract/198357
The Global Burden of Disease - Lancet web page
https://www.thelancet.com/gbd
In this episode Dr Katz talks about his path to preventative medicine and how important it is. We then get into the number one modifiable cause of chronic diseases which is diet.
Dr Katz was an early proponent of preventative medicine and is the founder and former president of the Yale-Griffin Prevention Research Center. As well as appearing on ABC News and Good Morning America he has written 13 books including The Truth About Food and How to eat. He is the founder and CEO of Diet ID a company that makes a tool to help measure and manage diet. And with that let me start the interview.
Dr Katz's home page
https://davidkatzmd.com/
Diet ID
https://www.dietid.com/
Dr Catherine Katz food site
https://cuisinicity.com/
Find Dr Katz's books on Amazon
How To Eat: All Your Food and Diet Questions Answered
https://amzn.to/3TiNbkd
The Truth About Food
https://amzn.to/3ARckLz
The Way to Eat: A Six-Step Path to Lifelong Weight Control
https://amzn.to/3QT2m27
Disease-Proof: Slash Your Risk of Heart Disease, Cancer, Diabetes, and More--by 80 Percent
https://amzn.to/3pQV96w
Papers referred to in this series
Actual Causes of Death in the United States
https://jamanetwork.com/journals/jama/article-abstract/409171
Actual Causes of Death in the United States, 2000
https://jamanetwork.com/journals/jama/article-abstract/198357
The Global Burden of Disease - Lancet web page
https://www.thelancet.com/gbd
In this episode Professor Furman shares his personal protocol to stay healthy and have low inflammation and talks about where the longevity industry is going and where he thinks it should put its focus.
Dr. David Furman is the Director of the Stanford 1000 Immunomes Project, Chief of the Center for AI and Data Science of Aging at the Buck Institute for Research on Aging, and a Adjunct Investigator for The National Scientific and Research Council, Austral University, Buenos Aires, Argentina. Dr. Furman received his Ph.D. (summa cum laude) from University of Buenos Aires, Argentina, for his work on the identification of factors produced by tumors that enable cancer cells to escape immune attack. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans and decipher how cumulative inflammatory responses associated with aging lead to an accelerated cardiovascular aging. Dr. Furman has published dozens of scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.
Dr Furman's paper on iAGE
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
https://www.nature.com/articles/s43587-021-00082-y
https://www.biorxiv.org/content/10.1101/840363v1
Prof David Furman’s Lab in Buck Institute Website
https://www.buckinstitute.org/lab/furman-lab/
Stanford 1000 Immunomes Project (KIP) Website:
https://med.stanford.edu/1000immunomes
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
$5 off any purchase if users use code MODERN5 at NOVOS Labs https://novoslabs.com/?ref=3957
Edifice Health aim not to only measure inflammatory age but to also to provide supplements and suggest actions to improve it. In this episode we talk about how these will be determined and some of the future direction. We also talk about the anti-inflammatory nature of caffeine.
Dr. David Furman is the Director of the Stanford 1000 Immunomes Project, Chief of the Center for AI and Data Science of Aging at the Buck Institute for Research on Aging, and a Adjunct Investigator for The National Scientific and Research Council, Austral University, Buenos Aires, Argentina. Dr. Furman received his Ph.D. (summa cum laude) from University of Buenos Aires, Argentina, for his work on the identification of factors produced by tumors that enable cancer cells to escape immune attack. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans and decipher how cumulative inflammatory responses associated with aging lead to an accelerated cardiovascular aging. Dr. Furman has published dozens of scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.
Dr Furman's paper on iAGE
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
https://www.nature.com/articles/s43587-021-00082-y
https://www.biorxiv.org/content/10.1101/840363v1
Prof David Furman’s Lab in Buck Institute Website
https://www.buckinstitute.org/lab/furman-lab/
Stanford 1000 Immunomes Project (KIP) Website:
https://med.stanford.edu/1000immunomes
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
$5 off any purchase if users use code MODERN5 at NOVOS Labs https://novoslabs.com/?ref=3957
In this episode Dr Furman discusses the Stanford 1000 immunome project, the company that he set up to commercialize the iAge test, Edifice Health and the test itself.
Dr. David Furman is the Director of the Stanford 1000 Immunomes Project, Chief of the Center for AI and Data Science of Aging at the Buck Institute for Research on Aging, and a Adjunct Investigator for The National Scientific and Research Council, Austral University, Buenos Aires, Argentina. Dr. Furman received his Ph.D. (summa cum laude) from University of Buenos Aires, Argentina, for his work on the identification of factors produced by tumors that enable cancer cells to escape immune attack. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans and decipher how cumulative inflammatory responses associated with aging lead to an accelerated cardiovascular aging. Dr. Furman has published dozens of scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.
Dr Furman's paper on iAGE
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
https://www.nature.com/articles/s43587-021-00082-y
https://www.biorxiv.org/content/10.1101/840363v1
Prof David Furman’s Lab in Buck Institute Website
https://www.buckinstitute.org/lab/furman-lab/
Stanford 1000 Immunomes Project (KIP) Website:
https://med.stanford.edu/1000immunomes
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
$5 off any purchase if users use code MODERN5 at NOVOS Labs https://novoslabs.com/?ref=3957
In this episode Dr Furman discusses what are the chief components of that make up the iAge clock and how they differ from the markers of acute inflammation. In particular CXCL9 is the main element of the iAge clock while classic marker of inflammation such as CRP, IL-6, TNF-alpha do not appear at all.
Dr. David Furman is the Director of the Stanford 1000 Immunomes Project, Chief of the Center for AI and Data Science of Aging at the Buck Institute for Research on Aging, and a Adjunct Investigator for The National Scientific and Research Council, Austral University, Buenos Aires, Argentina. Dr. Furman received his Ph.D. (summa cum laude) from University of Buenos Aires, Argentina, for his work on the identification of factors produced by tumors that enable cancer cells to escape immune attack. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans and decipher how cumulative inflammatory responses associated with aging lead to an accelerated cardiovascular aging. Dr. Furman has published dozens of scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.
Dr Furman's paper on iAGE
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
https://www.nature.com/articles/s43587-021-00082-y
https://www.biorxiv.org/content/10.1101/840363v1
Prof David Furman’s Lab in Buck Institute Website
https://www.buckinstitute.org/lab/furman-lab/
Stanford 1000 Immunomes Project (KIP) Website:
https://med.stanford.edu/1000immunomes
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
$5 off any purchase if users use code MODERN5 at NOVOS Labs https://novoslabs.com/?ref=3957
Dr. David Furman is the Director of the Stanford 1000 Immunomes Project, Chief of the Center for AI and Data Science of Aging at the Buck Institute for Research on Aging, and a Adjunct Investigator for The National Scientific and Research Council, Austral University, Buenos Aires, Argentina. Dr. Furman received his Ph.D. (summa cum laude) from University of Buenos Aires, Argentina, for his work on the identification of factors produced by tumors that enable cancer cells to escape immune attack. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans and decipher how cumulative inflammatory responses associated with aging lead to an accelerated cardiovascular aging. Dr. Furman has published dozens of scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.
Dr Furman's paper on iAGE
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
https://www.nature.com/articles/s43587-021-00082-y
https://www.biorxiv.org/content/10.1101/840363v1
Prof David Furman’s Lab in Buck Institute Website
https://www.buckinstitute.org/lab/furman-lab/
Stanford 1000 Immunomes Project (KIP) Website:
https://med.stanford.edu/1000immunomes
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
$5 off any purchase if users use code MODERN5 at NOVOS Labs https://novoslabs.com/?ref=3957
In this episode Dr Furman discusses chronic inflammation and how it differs from acute inflammation.
Dr. David Furman is the Director of the Stanford 1000 Immunomes Project, Chief of the Center for AI and Data Science of Aging at the Buck Institute for Research on Aging, and a Adjunct Investigator for The National Scientific and Research Council, Austral University, Buenos Aires, Argentina. Dr. Furman received his Ph.D. (summa cum laude) from University of Buenos Aires, Argentina, for his work on the identification of factors produced by tumors that enable cancer cells to escape immune attack. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans and decipher how cumulative inflammatory responses associated with aging lead to an accelerated cardiovascular aging. Dr. Furman has published dozens of scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.
Dr Furman's paper on iAGE
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
https://www.nature.com/articles/s43587-021-00082-y
https://www.biorxiv.org/content/10.1101/840363v1
Prof David Furman’s Lab in Buck Institute Website
https://www.buckinstitute.org/lab/furman-lab/
Stanford 1000 Immunomes Project (KIP) Website:
https://med.stanford.edu/1000immunomes
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
$5 off any purchase if users use code MODERN5 at NOVOS Labs https://novoslabs.com/?ref=3957
In this episode Dr Kaufmann talks about her personal protocol, how many supplements she takes (52) and some of the more advanced therapies that she uses, such as exosomes.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of the book The Kaufmann Protocol: Why We Age and How to Stop It. In the book she describes the mechanisms of aging on a cellular level and the best supplements to slow down its progress.
Links for Dr Kaufmann
The Kaufmann Protocol website
https://kaufmannprotocol.com/
The Kaufmann Protocol:
https://amzn.to/3rhBAq7
In this episode Dr Kaufmann talks about supplements and eye drops for aging eyes, including carnosine eye drops which may be able to reverse long sight.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of the book The Kaufmann Protocol: Why We Age and How to Stop It. In the book she describes the mechanisms of aging on a cellular level and the best supplements to slow down its progress.
Links for Dr Kaufmann
The Kaufmann Protocol website
https://kaufmannprotocol.com/
The Kaufmann Protocol:
https://amzn.to/3rhBAq7
In this episode Dr Kaufmann talks about supplements, that can be used to address loss of hair and loss of hair colour, including Ecklonia Cava a supplement from Japanese seaweed. We also cover sarcopenia where the supplements are leucine, collagen, resveratrol or pterostilbene and a source of nicotinamide, such as NMN or NR.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of the book The Kaufmann Protocol: Why We Age and How to Stop It. In the book she describes the mechanisms of aging on a cellular level and the best supplements to slow down its progress.
Links for Dr Kaufmann
The Kaufmann Protocol website
https://kaufmannprotocol.com/
The Kaufmann Protocol:
https://amzn.to/3rhBAq7
In this episode Dr Kaufmann talks about the her list of required supplements for those who are over 40. This has the 5 from her original book, Pterostilbene, Astaxanthin, Nicotinamide, Carnosine, Curcumin. To which she has now added Quercetin, Lactoferrin and Spermidine. We also discuss some of them in more detail, touching on rapamycin and delivery systems such as liposomes and nano micelles.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of the book The Kaufmann Protocol: Why We Age and How to Stop It. In the book she describes the mechanisms of aging on a cellular level and the best supplements to slow down its progress.
Links for Dr Kaufmann
The Kaufmann Protocol website
https://kaufmannprotocol.com/
The Kaufmann Protocol:
https://amzn.to/3rhBAq7
In this episode Dr Kaufmann talks about her system for rating molecules for their efficacy based on the scientific evidence available. She also discusses her new book which extends from her first book and adds more supplements to the list.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of the book The Kaufmann Protocol: Why We Age and How to Stop It. In the book she describes the mechanisms of aging on a cellular level and the best supplements to slow down its progress.
Links for Dr Kaufmann
The Kaufmann Protocol website
https://kaufmannprotocol.com/
The Kaufmann Protocol:
https://amzn.to/3rhBAq7
In this video Dr Kaufmann provides an introduction of what led her to start studying aging and the process that she used to develop her 7 tenets. She then goes through the tenets explaining what each one is. She uses the analogy of a factory to show how the pieces fit together.
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of the book The Kaufmann Protocol: Why We Age and How to Stop It. In the book she describes the mechanisms of aging on a cellular level and the best supplements to slow down its progress.
Links for Dr Kaufmann
The Kaufmann Protocol website
https://kaufmannprotocol.com/
The Kaufmann Protocol:
https://amzn.to/3rhBAq7
In this episode Dr Longo talks the diet and exercise for longevity and whether it is necessary to exercise when fasting. He also shares his own longevity protocol
Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interventions to activate stem cell- based regeneration to promote longevity. In 2018, TIME Magazine named Professor Longo as one of the 50 most influential people in health care for his research on fasting-mimicking diets as a way to improve health and prevent disease.
Dr Longo's book on Amazon
The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight
https://amzn.to/30PmY6j
Professor Longo's Facebook page.
https://www.facebook.com/profvalterlongo/
Create Cures Foundation
https://www.createcures.org/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Dr Longo talks about the best timing for intermittent fasting, which he says is 12/12 and why 16/8 is not optimal. We also talk about eating patterns during the feeding window.
Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interventions to activate stem cell- based regeneration to promote longevity. In 2018, TIME Magazine named Professor Longo as one of the 50 most influential people in health care for his research on fasting-mimicking diets as a way to improve health and prevent disease.
Dr Longo's book on Amazon
The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight
https://amzn.to/30PmY6j
Professor Longo's Facebook page.
https://www.facebook.com/profvalterlongo/
Create Cures Foundation
https://www.createcures.org/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Dr Longo talks about how the fast mimicking diet can be used either in combination with other interventions or on its own to treat the major diseases of aging. He also covers progress towards getting the FMD approved as a drug by the FDA.
Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interventions to activate stem cell- based regeneration to promote longevity. In 2018, TIME Magazine named Professor Longo as one of the 50 most influential people in health care for his research on fasting-mimicking diets as a way to improve health and prevent disease.
Dr Longo's book on Amazon
The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight
https://amzn.to/30PmY6j
Professor Longo's Facebook page.
https://www.facebook.com/profvalterlongo/
Create Cures Foundation
https://www.createcures.org/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Dr. Longo talks about some of the practical aspects of the FMD, such as how often it should be followed and compares its benefits to those of exercise.
Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interventions to activate stem cell- based regeneration to promote longevity. In 2018, TIME Magazine named Professor Longo as one of the 50 most influential people in health care for his research on fasting-mimicking diets as a way to improve health and prevent disease.
Dr Longo's book on Amazon
The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight
https://amzn.to/30PmY6j
Professor Longo's Facebook page.
https://www.facebook.com/profvalterlongo/
Create Cures Foundation
https://www.createcures.org/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Dr. Longo talks about the benefits of the FMD and who it is most appropriate for.
Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interventions to activate stem cell- based regeneration to promote longevity. In 2018, TIME Magazine named Professor Longo as one of the 50 most influential people in health care for his research on fasting-mimicking diets as a way to improve health and prevent disease.
Dr Longo's book on Amazon
The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight
https://amzn.to/30PmY6j
Professor Longo's Facebook page.
https://www.facebook.com/profvalterlongo/
Create Cures Foundation
https://www.createcures.org/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Dr. Longo talks about his views on fasting and provides an introduction of what the FMD is and why it was first created.
Valter Longo, PhD, is a professor of gerontology and biological sciences and the director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology. Professor Longo has thirty years of experience in the field of longevity and healthy nutrition. His most recent studies focus on the use of Fast-Mimicking diet interventions to activate stem cell- based regeneration to promote longevity. In 2018, TIME Magazine named Professor Longo as one of the 50 most influential people in health care for his research on fasting-mimicking diets as a way to improve health and prevent disease.
Dr Longo's book on Amazon
The Longevity Diet: Slow Aging, Fight Disease, Optimize Weight
https://amzn.to/30PmY6j
Professor Longo's Facebook page.
https://www.facebook.com/profvalterlongo/
Create Cures Foundation
https://www.createcures.org/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Dr Tanzi discusses whether Alzheimer's and other brain diseases are happening at a younger age and why that might be, along with his own protocol to maintaining a young and healthy mind!
Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.
Professor Tanzi's page at Harvard
https://brain.harvard.edu/?people=rudolph-e-tanzi
Books by Professor Tanzi
https://amzn.to/3kyqxVQ
Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being
https://amzn.to/3zsenSl
The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life
https://amzn.to/3kwwwKx
Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being
https://amzn.to/3zx5h6Q
Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Dr Tanzi talks about some of the future potential options are to treat Alzheimer's once it has started and neural inflammation has set in.
Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.
Professor Tanzi's page at Harvard
https://brain.harvard.edu/?people=rudolph-e-tanzi
Books by Professor Tanzi
https://amzn.to/3kyqxVQ
Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being
https://amzn.to/3zsenSl
The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life
https://amzn.to/3kwwwKx
Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being
https://amzn.to/3zx5h6Q
Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Tanzi talks about SHIELD, his acronym for the things that you can do to protect your brain. S - Sleep, H - Handle Stress, I - Interactions with friends, E - Exercise, L - Learn new things and D - Diet and we dive into detail on a few of them.
Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.
Professor Tanzi's page at Harvard
https://brain.harvard.edu/?people=rudolph-e-tanzi
Books by Professor Tanzi
https://amzn.to/3kyqxVQ
Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being
https://amzn.to/3zsenSl
The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life
https://amzn.to/3kwwwKx
Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being
https://amzn.to/3zx5h6Q
Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Tanzi talks about the causes of Alzheimer's, from the plaques and tangles to neural inflammation, and what treatments exist for these symptoms.
Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.
Professor Tanzi's page at Harvard
https://brain.harvard.edu/?people=rudolph-e-tanzi
Books by Professor Tanzi
https://amzn.to/3kyqxVQ
Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being
https://amzn.to/3zsenSl
The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life
https://amzn.to/3kwwwKx
Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being
https://amzn.to/3zx5h6Q
Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
Dr. Rudolph Tanzi is the Director of the Genetics and Aging Research Unit, Co-Director of the McCance Center for Brain Health, Co-Director of the Mass General Institute for Neurodegenerative Disease, and Vice-Chair of Neurology (Research), at Massachusetts General Hospital, and the Joseph P. and Rose F. Kennedy Professor of Neurology at Harvard Medical School. Dr. Tanzi co-discovered the first three Alzheimer’s disease genes, including APP and directs the Cure Alzheimer’s Fund Alzheimer’s Genome Project, which identified the first neuroinflammation-related Alzheimer’s gene, CD33. He has also been developing therapies for treating and preventing AD using 3D human neural glial culture models of AD and is now testing them in various clinical trials. Dr. Tanzi has published over 600 papers, received numerous awards, including the Metropolitan Life Award, Potamkin Prize, Smithsonian American Ingenuity Award, and was one of the TIME100 Most Influential People in the World. Dr. Tanzi is a New York Times bestselling author, who co-authored “Decoding Darkness” “Super Brain”, “Super Genes”, and “The Healing Self”. He has also hosted three PBS shows and made numerous appearances on network and cable news and medical television shows. In his spare time, he plays keyboards for Joe Perry, Aerosmith and other musicians.
Professor Tanzi's page at Harvard
https://brain.harvard.edu/?people=rudolph-e-tanzi
Books by Professor Tanzi
https://amzn.to/3kyqxVQ
Super Genes: Unlock the Astonishing Power of Your DNA for Optimum Health and Well-Being
https://amzn.to/3zsenSl
The Healing Self: A Revolutionary New Plan to Supercharge Your Immunity and Stay Well for Life
https://amzn.to/3kwwwKx
Super Brain: Unleashing the Explosive Power of Your Mind to Maximize Health, Happiness, and Spiritual Well-Being
https://amzn.to/3zx5h6Q
Decoding Darkness: The Search For The Genetic Causes Of Alzheimer's Disease
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Harries discusses the attitude of governments to aging, the most promising aging technologies and her personal protocol for staying healthy.
Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.
She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.
Professor Harries site at University of Exeter
https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries
Senisca home page
https://www.senisca.com/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Harries discusses her company Senisca, her theory of aging and getting funded for aging research
Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.
She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.
Professor Harries site at University of Exeter
https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries
Senisca home page
https://www.senisca.com/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Harries discusses how oligonucleotides can be used for as a very precise way to control gene expression.
Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.
She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.
Professor Harries site at University of Exeter
https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries
Senisca home page
https://www.senisca.com/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Harries discuss how she and her team used resveralogs initially and later HS2 donors to change the regulation of splicing factors and in doing so, reverse cellular senescence. We also touch on what a therapy based on this might look like in the clinic.
Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.
She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.
Professor Harries site at University of Exeter
https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries
Senisca home page
https://www.senisca.com/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Harries discuss whether RNA Splicing meets the criteria of a hallmark of aging. To qualify it should i) manifest during normal aging ii) its aggravation should accelerate aging and iii) it amelioration should slow or reverse aging. Prof Harries goes through each of these criteria with respect to RNA splicing.
Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.
She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.
Professor Harries site at University of Exeter
https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries
Senisca home page
https://www.senisca.com/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this episode Professor Harries addresses some of the fundamental questions about RNA splicing and how it regulates gene expression
Lorna Harries is Professor of Molecular Genetics at the University of Exeter College of Medicine and Health where she leads the RNA-mediated disease mechanisms group. Her group has interests in messenger RNA processing and epigenetic gene regulation in the context of ageing and chronic disease.
She is a Co-Founder & the Chief Scientific Officer for SENISCA (www.senisca.com), a senotherapeutics company. Her team were the first to report dysregulation of alternative splicing as a new, and druggable, hallmark of ageing. With that, let me start the interview.
Professor Harries site at University of Exeter
https://medicine.exeter.ac.uk/people/profile/index.php?web_id=Lorna_Harries
Senisca home page
https://www.senisca.com/
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Professor Robbins discusses reprogramming using the Yamanaka Factors as the most promising technology in aging and its relationship to DNA damage. He also talks about his personal protocol for longevity.
Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota.
He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials.
Professor Robbins' page at University of Minnesota
https://robbins.umn.edu/dr-paul-robbins-phd
Institute of the Biology of Aging and Metabolism
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Professor Robbins discusses the work his lab is doing with Exosomes or EV (Extra-Cellular Vesicles) and how these can impact senescent cells by suppressing SASP as senomorphics
Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota.
He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials.
Professor Robbins' page at University of Minnesota
https://robbins.umn.edu/dr-paul-robbins-phd
Institute of the Biology of Aging and Metabolism
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Professor Robbins discusses the work his lab is doing, investigate what makes centenarians different at the genetic level and then to develop drugs which can mimic these differences. One of these differences is in SIRT6 and he talks about what they are doing to better understand this in collaboration with Prof Vera Gorbunova and colleagues at the Albert Einstein College of Medicine.
Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota.
He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials.
Professor Robbins' page at University of Minnesota
https://robbins.umn.edu/dr-paul-robbins-phd
Institute of the Biology of Aging and Metabolism
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In this video Professor Robbins discusses the process by which his and other labs look for possible senolytics. He also talks about fisetin and why he chooses to take it
Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota.
He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials.
Professor Robbins' page at University of Minnesota
https://robbins.umn.edu/dr-paul-robbins-phd
Institute of the Biology of Aging and Metabolism
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
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Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
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In this video Professor Robbins discusses cellular senescence in general then dives into cellular senescence in the immune system. As immune cells are present through out the body, embedded in different tissues, their senescence has the ability to impact the system in ways that other senescent cells may not.
Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota.
He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials.
Professor Robbins' page at University of Minnesota
https://robbins.umn.edu/dr-paul-robbins-phd
Institute of the Biology of Aging and Metabolism
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
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Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Professor Robbins discusses his theory of aging, the Unitary Theory of Fundamental Aging and how that helped his choice to work on aging rather than specific diseases.
Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota.
He was part of a collaborative team that was the first to identify senotherapeutic compounds, able to reduce the senescent cell burden and extend healthspan and lifespan in mouse models that are now in more than 15 clinical trials.
Professor Robbins' page at University of Minnesota
https://robbins.umn.edu/dr-paul-robbins-phd
Institute of the Biology of Aging and Metabolism
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Dr Gundry talks about his theory of aging (which involves the gut and mitochondria of course!) and also his longevity protocol.
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
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In this video Dr Gundry discusses other ways of encouraging mitochondrial uncoupling, particularly in brown fat. He also covers thermogenic compounds, like ginger and tumeric and why they make you feel hot.
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Dr Gundry discusses the top three supplements for healthy aging and also melatonin as a mitochondrial anti-oxidant
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Dr Gundry discusses essential fatty acids, including ALA or alpha linoleic acid and C15. We also discuss the long term impact of the keto diet.
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Dr Gundry discusses eating windows, which are best and how long we need to be fasting for the generation of ketones to start. We also discuss leaky gut!
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Dr Gundry discusses how ketones impact the brain.
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Dr Gundry discusses metabolic flexibility and why it is so important for ketosis. Insulin resistance means that free fatty acids cannot be released from fat cells to be converted to ketones. In which case the body has neither glucose nor ketones, leading to starvation of neurons in the brain.
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Dr Gundry introduces mitochondrial uncoupling and why it is such an important part of the ketosis.
Dr Steven Gundry is a world-renowned heart surgeon, medical researcher, and author. During his 40-year career, Dr Gundry has performed 10,000 heart operations and developed patented, life-saving medical technology. He has published multiple bestselling books focused on nutrition and health including the New York Times best seller the Plant Paradox. In this interview we discuss his latest book, Unlocking the Keto Code where Dr Gundry looks why ketogenic diets are misunderstood and how they can be made more effective and easier to follow and with that let me start the interview.
The links to Dr Gundry's YouTube channel, Blog, Twitter and Facebook are available from his home page.
https://drgundry.com/
Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation (The Plant Paradox, 7)
https://amzn.to/3ID7pi4
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
15% off Bulletproof products at https://www.bulletproof.com/ with discount code HEALTHSPAN15.
Renue By Science 10% discount code MHS at https://renuebyscience.com/all-products-2/
10% off all products at DoNotAge with code MODERNHEALTHSPAN at https://donotage.org/
In this video Professor Faragher talks about his personal protocol for longevity, and his acid test for whether an intervention is worthwhile, how does it compare to the cost and benefits of a gym membership.
Professor Faragher's audio freezes a couple of times for a short time. Apologies for the interruption.
Professor Richard Faragher is Professor of biological gerontology at the University of Brighton and has been studying the relationship between cellular senescence and aging for more than 30 years. He is one of the leading experts on ageing and has become one of only three British academics to ever win a Glenn Award for research. He recently led a team showing the reversal of cellular senescence with derivatives of resveratrol.
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In this video Professor Faragher talks about his experience working as an advisor to Sergey Young's Longevity Vision Fund.
Professor Faragher's audio freezes a couple of times for a short time. Apologies for the interruption.
Professor Richard Faragher is Professor of biological gerontology at the University of Brighton and has been studying the relationship between cellular senescence and aging for more than 30 years. He is one of the leading experts on ageing and has become one of only three British academics to ever win a Glenn Award for research. He recently led a team showing the reversal of cellular senescence with derivatives of resveratrol.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
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In this video Professor Faragher talks about his experience in the aging field and how it has changed and also looks to what he sees as the most promising interventions that are being studied.
Professor Richard Faragher is Professor of biological gerontology at the University of Brighton and has been studying the relationship between cellular senescence and aging for more than 30 years. He is one of the leading experts on ageing and has become one of only three British academics to ever win a Glenn Award for research. He recently led a team showing the reversal of cellular senescence with derivatives of resveratrol.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
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In this video Professor Faragher talks what concentration would be achievable in vivo and whether this could be done with natural sources of senolytics such as fisten from strawberries. He also discusses the nature of cells after they have been rescued from senescence.
Professor Faragher's audio freezes a couple of times for a short time. Apologies for the interruption.
Professor Richard Faragher is Professor of biological gerontology at the University of Brighton and has been studying the relationship between cellular senescence and aging for more than 30 years. He is one of the leading experts on ageing and has become one of only three British academics to ever win a Glenn Award for research. He recently led a team showing the reversal of cellular senescence with derivatives of resveratrol.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
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In this video Professor Faragher talks about his teams experiment to reverse cellular senescence with resveratrol and some derivatives from the molecule. He also covers the expected mechanism.
Professor Faragher's audio freezes a couple of times for a short time. Apologies for the interruption.
Professor Faragher's audio freezes a couple of times for a short time. Apologies for the interruption.
Professor Richard Faragher is Professor of biological gerontology at the University of Brighton and has been studying the relationship between cellular senescence and aging for more than 30 years. He is one of the leading experts on ageing and has become one of only three British academics to ever win a Glenn Award for research. He recently led a team showing the reversal of cellular senescence with derivatives of resveratrol.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
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In this video Professor Faragher talks about senescent cells, how they form and some of their effects on the body.
Professor Faragher's audio freezes a couple of times for a short time. Apologies for the interruption.
Professor Richard Faragher is Professor of biological gerontology at the University of Brighton and has been studying the relationship between cellular senescence and aging for more than 30 years. He is one of the leading experts on ageing and has become one of only three British academics to ever win a Glenn Award for research. He recently led a team showing the reversal of cellular senescence with derivatives of resveratrol.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
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In this video Dr Faragher talks about why we age including some aspects of human history that make us unique.
Professor Faragher's audio freezes a couple of times for a short time. Apologies for the interruption.
Professor Richard Faragher is Professor of biological gerontology at the University of Brighton and has been studying the relationship between cellular senescence and aging for more than 30 years. He is one of the leading experts on ageing and has become one of only three British academics to ever win a Glenn Award for research. He recently led a team showing the reversal of cellular senescence with derivatives of resveratrol.
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In this video Dr Perlmutter about some of the other things which can impact our uric acid levels, such as stress, lack of sleep and an unhealthy microbiome.
Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author.
His books have been published in 32 languages and include the bestseller Grain Brain. His newly published book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases.
He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr Perlmutter's website
https://www.drperlmutter.com/
His book is available on Amazon and other locations
https://tinyurl.com/2p9x57kj
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In this video Dr Perlmutter talks more generally about diet and uric acid, particularly purines and alcohol. He also discusses supplements such as quercetin that can help reduce our levels of uric acid.
Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author.
His books have been published in 32 languages and include the bestseller Grain Brain. His newly published book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases.
He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr Perlmutter's website
https://www.drperlmutter.com/
His book is available on Amazon and other locations
https://tinyurl.com/2p9x57kj
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
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In this video Dr Perlmutter diet and uric acid with a particular focus on fructose, how it is metabolized and how ubiquitous it is in our food supply.
Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author.
His books have been published in 32 languages and include the bestseller Grain Brain. His newly published book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases.
He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr Perlmutter's website
https://www.drperlmutter.com/
His book is available on Amazon and other locations
https://tinyurl.com/2p9x57kj
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr Perlmutter discusses the optimal level of uric acid and how to measure. He also covers how uric acid levels change with age and fasting.
Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author.
His books have been published in 32 languages and include the bestseller Grain Brain. His newly published book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases.
He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr Perlmutter's website
https://www.drperlmutter.com/
His book is available on Amazon and other locations
https://tinyurl.com/2p9x57kj
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr Perlmutter introduces uric acid, where it comes from and its impact on our metabolism and overall health.
Dr. Perlmutter is a Board-Certified Neurologist and six-time New York Times bestselling author.
His books have been published in 32 languages and include the bestseller Grain Brain. His newly published book, Drop Acid, focuses on the pivotal role of uric acid in metabolic diseases.
He is recognized internationally as a leader in the field of nutritional influences in neurological disorders.
Dr Perlmutter's website
https://www.drperlmutter.com/
His book is available on Amazon and other locations
https://tinyurl.com/2p9x57kj
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Kirkland talks about the future of aging and how the biology of aging affects everyone and should not be thought of as only relevant to older people. He also discusses the path of bringing senolytics to wider use.
Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism.
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In this video Dr. Kirkland talks about what we can do to reduce our senescent cell burden with lifestyle choices and how there is a grouping of health organizations measuring health markers across multiple trials to gather data on aging.
Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Kirkland talks about the senolytics that the Mayo Clinic is using in the on going trials, dasatinib, Fisetin and Quercetin. He also talks about the way the work and the schedule to taking them
Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Kirkland talks about how and why senescent cells are formed, how they can be removed and what the benefits of removing them is.
Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Kirkland gives a wide introduction to senescent cells including why we have them, what purpose they serve and what damage they can cause.
Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Kirkland explains his theory of aging and discusses the Unitary Theory of Fundamental Aging, which posits that there are underlying pillars of aging which cause the diseases of aging and that are interlinked. Dr. Kirkland offers some examples of these linkages
Dr. James Kirkland is Director of the Robert and Arlene Kogod Center on Aging at Mayo Clinic and Noaber Foundation Professor of Aging Research. Dr. Kirkland's research focuses on cellular senescence, age-related adipose tissue and metabolic dysfunction, and development of agents and strategies for targeting fundamental aging mechanisms to treat age-related chronic diseases and disabilities and to extend healthspan. He published the first article about drugs that clear senescent cells, senolytic agents. A novel, mechanism-based, hypothesis-driven drug development paradigm was used to discover senolytic drugs. Based on the observation that senescent cells release factors that cause apoptosis of the cells around them, yet are themselves resistant to apoptosis, Dr. Kirkland hypothesized that senescent cells utilize senescent cell anti-apoptotic pathways (SCAPs) for protection from their own senescence-associated secretory phenotype (SASP). Using bioinformatics analyses of senescent vs. non-senescent cells and RNA interference, Dr. Kirkland identified these SCAPs and verified their importance for senescent cell survival. Dr. Kirkland used bioinformatics approaches to identify agents that target key nodes across the SCAP network and demonstrated these drugs are senolytic in rodent and human cultured cells and mice in vivo. These senolytic drugs include Dasatinib (D), Quercetin (Q), Fisetin, Navitoclax, and related compounds. Dr. Kirkland showed these agents delay, prevent, or alleviate multiple disorders in mouse models of human chronic diseases and aging phenotypes. Conditions alleviated in mouse models include frailty, diabetes, hepatic steatosis, cirrhosis, renal dysfunction, neuropsychiatric disorders, dementias, pulmonary fibrosis, osteoporosis, osteoarthritis, retinal degeneration, diastolic dysfunction, cardiac ischemia, vascular hyporeactivity, infertility, and skin disorders, among others. He demonstrated that intermittent, orally administered senolytics reduce senescent cell abundance in adipose tissue and blood markers of senescent cell burden in blood of patients with diabetic kidney disease. He and collaborators found that a brief course of senolytics enhances physical function and reduces frailty in patients with idiopathic pulmonary fibrosis, a fatal, cellular-senescence-driven disease for which available treatments have been unsatisfactory. Multiple clinical trials are currently underway of the senolytics that Dr. Kirkland discovered. He is a scientific advisory board member for several companies and academic organizations. In addition to being President-Elect of AFAR, he has been a member of the National Advisory Council on Aging of the National Institutes of Health, and past chair of the Biological Sciences Section of the Gerontological Society of America. He holds honorary appointments at Boston University and the University of Groningen in the Netherlands. He is a board-certified specialist in internal medicine, geriatrics, and endocrinology and metabolism.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Fahy shares his personal longevity protocol. And in particular talks about Carnosine, a supplement that I have not looked at before.
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
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You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
Apologies for missing the last couple of weeks. Will try to get back on track!
In this episode Dr Fahy discusses how he is working with Dr Katcher to reproduce the results that he had with rats in dogs.
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Fahy shares his opinion on some of the up and coming anti-aging therapies, including NAD boosters, Hyperbaric Oxygen Chambers and senolytics.
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Fahy discusses the next steps for TRIIM-X, how to participate and what to do if you would like to invest in Intervene Immune. Apologies for the spelling mistake in the thumbnail!
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Fahy discusses what we can do to make the most of our thymus without the growth hormone treatment, what the timing makes sense for rejuvenation of the thymus and whether the thymus is tied to the other hallmarks of aging.
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Fahy discusses the TRIIM-X trial, which is the follow on to the original TRIIM trial. We discuss the differences from TRIIM and the current state of the trial. It is still open for enrolment!
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr. Fahy discusses growth hormone and it benefits in aging. He also covers the safety checks that they performed after the participants started with the protocol. In particular they saw reduced markers of cancer and cancer risk
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr Fahy introduces the TRIIM trial and talks about the regimen of drugs that they use, why they choose the ones they did and the kind of personalization that they performed during the trial.
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Dr Fahy explains his theory of aging and why he thinks the way that he does.
Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan
In this video Professor Campisi talks her personal protocol for staying healthy and some of the research that her lab is now working on.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Campisi talks her personal protocol for staying healthy and some of the research that her lab is now working on.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Campisi talks about what lifestyle habits can minimize the senescent cells in our body.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Campisi talks about why detecting senescent cells is difficult and the biomarker that her team recently found that shows how effective a senolytic is and can also be used to determine the level of senescent burden.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Campisi talks about how senescent cells are heterogeneous and their interaction with the immune system which leads to inflammaging.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Campisi talks about how senescent cells are heterogeneous and their interaction with the immune system which leads to inflammaging.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Campisi talks why we have senescent cells, a possible schedule for taking senolytics, and senescent cells and cancer.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Campisi talks about what led her to study aging. She also covers her ideas on why we age and how senescent cells fit into that.
The Campisi lab at the Buck Institute
https://www.buckinstitute.org/lab/campisi-lab/
Judith Campisi is a professor of biogerontology at the Buck Institute for Research on Aging. She is co-editor in chief of the Aging Journal, and founder of the pharmaceutical company Unity Biotechnology. Prof Campisi is widely recognized for her work on senescent cells and their influence on many manifestations of aging. Her laboratory discovered Senescence Associated Secretory Phenotype (SASP) and also discovered the first non-invasive biomarker to verify the efficacy of senolytics.
In this video Professor Church talks about his work on his project to recreate a mammoth in the Siberian Arctic. He also talks about the latest work that his lab is working on.
George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis".
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
In this video Professor Church talks about why everyone should get their complete genome sequenced and how we genetic engineering has created organisms which are immune to all viruses, and how potentially this technology could be used for humans.
Nebula Genomics - full genome sequencing company started by Professor Church.
https://nebula.org/whole-genome-sequencing-dna-test/
George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis".
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
In this video Professor Church talks about the latest updates in xenotransplantation technology and how they are getting close to clinical trials with the latest Pig 3.0 that has been built with the gene technologies from his lab. He also talks about universal chimeric antigen receptors (CAR) T-Cells for stem cell transplantation.
George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis".
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
In this video Professor Church talks about the latest techniques for building AAVs and using them to delivery gene therapies.
George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis".
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
In this video Professor Church talks how he is using gene therapy to target aging and the benefits of gene therapy when compared to using small molecules. He talks about the study where his lab used a small number of gene therapies to target five or more diseases of aging and the follow up they are now doing.
George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis".
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
In this video Professor Church talks about his theory of aging and touches on his ideas on the future of aging.
George Church is the Robert Winthrop Professor of Genetics at Harvard Medical School, a Professor of Health Sciences and Technology at Harvard and MIT. Professor Church helped initiate the Human Genome Project in 1984 and the Personal Genome Project in 2005. He is widely recognized for his innovative contributions to genomic science and his many pioneering contributions to chemistry and biomedicine. He has co-authored 580 paper, 143 patent publications & the book "Regenesis".
If you would like to support our channel, we’d love a coffee ☕…thank you! https://www.buymeacoffee.com/mhealthspan
In Episode 6 Dr. Lithgow talks about the latest research that he is doing in his lab, what his personal longevity protocol is as well how we can move forward with making interventions available for aging.
Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research. *************
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In Episode 5 Dr. Lithgow talks about the different forms of AKG and why they chose to go with CaAKG. He also touches on the difficulty in doing the kind of head to head studies that would be able to see if either was more effective.
Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.
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If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan
In Episode 4 Dr. Lithgow talks about , some other potential benefits of AKG rather than extend healthspan and lifespan.
Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.
************* If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan
In Episode 3 Dr. Lithgow introduces AKG, or Alpha Ketoglutarate and talks about a recent trial that they did with mice. In the trial they saw both increased lifespan and healthspan, mostly in the female mice.
Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.
In the talk Dr. Lithgow discusses the current drugs that are available along with some of the limitations of the studies that we are currently doing.
Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research. *************
If you would like to support our channel, we’d love a coffee…thank you! https://www.buymeacoffee.com/mhealthspan
In Episode 1 Dr. Lithgow talks about his journey to study aging, his thoughts on why we age and whether there is limit to the age that humans can live to.
Dr. Gordon Lithgow, is a professor and vice president of Academic Affairs at the Buck Institute. Dr. Lithgow's research focuses on uncovering genes and small molecules that prolong lifespan through enhanced molecular stability. Dr. Lithgow has been recognized with a Glenn Award for Research in Biological Mechanisms of Aging and the Tenovus Award for Biomedical Research.
In this video Dr. Sabatini discusses some of the life style interventions that affect our longevity and his personal regimen. This is the last episode of Dr. Sabatani Interview Series.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism
Some key references.
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf
Twenty-five years of mTOR: Uncovering the link from nutrients to growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/
mTOR introduction YouTube Series with Dr. Sabatini
- https://www.youtube.com/watch?v=EnIerDljc7g
- https://www.youtube.com/watch?v=defOfBEuw_M
- https://www.youtube.com/watch?v=tGA9RALG66s
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research.
He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism
In this video Dr. Sabatini discusses how diet effects mTOR activation. He also talks about calorie restriction and intermittent fasting.
Some key references.
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf
Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/
In this video Dr. Sabatini discusses rapamycin, how it acts on mTORC1 and mTORC2 and the rapalogs, drugs which are similar to rapamycin but may be more clinically effective.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism
Some key references.
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf
Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/
mTOR introduction YouTube Series with Dr. Sabatini
https://www.youtube.com/watch?v=EnIerDljc7g
https://www.youtube.com/watch?v=defOfBEuw_M
https://www.youtube.com/watch?v=tGA9RALG66s
In this video Dr. Sabatini discusses his recent paper and in particular how the health of the mitochondria impact the activation of mTOR and how this is signaled.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism Some key references.
The paper discussed in the video. Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf
Twenty-five years of mTOR: Uncovering the link from nutrients to growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism In this video Dr. Sabatini discusses how mTOR impacts lifespan and whether its actions change with age
Some key references.
Twenty-five years of mTOR: Uncovering the link from nutrients to growth https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/
mTOR introduction YouTube Series with Dr. Sabatini https://www.youtube.com/watch?v=EnIerDljc7g https://www.youtube.com/watch?v=defOfBEuw_M https://www.youtube.com/watch?v=tGA9RALG66s
In this video Dr. Sabatini discusses the role of mTOR as the master regulator of the cell and distinguishes between mTORC1 and mTORC2.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism
In this video talks about the biological age measurement in his research study and also his views on Exercise as an important contributor for extending healthspan.
We also look at a paper by his team which looks in depth at the effects of acute exercise on the biochemistry of the body. https://www.sciencedirect.com/science/article/abs/pii/S0092867420305080
Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.
Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.
In this episode, Dr. Snyder will talk about Ageotypes, defined as the part of the body where the aging process was most active based on a research study led by him, which could explain why we age at different rates. The study tracked 106 healthy individuals, aged between 29 and 75, taking blood and biological samples to investigate each person at a deep molecular level. They carried out tests at least five times over two years in order to record any changes, with Dr. Snyder even taking part as a subject of his own research. Researchers discovered four “ageotypes,” – defined as the part of the body where the aging process was most active. Those involved in the trial tended to age most within the immune system, kidney, liver, or at a metabolic level. Ageotypes may provide a molecular assessment of personal aging, reflective of personal lifestyle and medical history, that may ultimately be useful in monitoring and intervening in the aging process. Personal aging markers and ageotypes revealed by deep longitudinal profiling
Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.
In this video, Dr. Snyder talks about the projects in his lab looking at COVID-19 and how wearables can help to fight the disease.
Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.
In this podcast, Dr. Snyder will discuss with us how commercial wearables can detect a viral infection even before the obvious symptoms appear
Some resources for more information on Dr. Snyder: Dr. Synder Book: Genomics and Personalized Medicine: What Everyone Needs to Know https://amzn.to/3309oLD
Dr. Snyder’s Lab at Standford University http://med.stanford.edu/snyderlab.html
Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.
In this video, Dr. Snyder discusses how we can manage our health with big data. He uses his personal experience as an example of what we can learn through monitoring our physiological markers.
Some resources for more information on Dr. Snyder: Dr. Synder Book: Genomics and Personalized Medicine: What Everyone Needs to Know https://amzn.to/3309oLD
Dr. Snyder’s Lab at Standford University http://med.stanford.edu/snyderlab.html
Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai’s New Book - https://amzn.to/30MOsGT
Aging and Centenarian Studies : This is the part 2 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine.
Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award.
Dr. Barzilai’s New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process.
In this interview Dr. Barzilai discusses his Metformin, rapamycin and the TAME trial, a large scale clinical trial of Metformin to see if it can reduce or delay the effects of aging.
Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation.
Disclosure: Some of the links provided are affiliate links. Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel!
Our YouTube Channel is here Please visit us for more longevity and extended healthspan content.
In this podcast Dr. de Grey talks about why SENS was founder and why the research that the foundation undertakes is not done by other organizations.
Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process.
The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
https://amzn.to/37lBX7A
SENS Foundation
https://www.sens.org/
2013 paper on the 9 hallmarks of aging
https://www.sciencedirect.com/science/article/pii/S0092867413006454
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging
Our YouTube Channel is here Please visit us for more longevity and extended healthspan content.
In this podcast Dr. de Grey will talk about the hallmarks of aging that he defined and more specifically about the stiffening of the extra cellular matrix a hallmark that was in his original list but not the 2013 paper.
Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process.
The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
https://amzn.to/37lBX7A
SENS Foundation
https://www.sens.org/
2013 paper on the 9 hallmarks of aging
https://www.sciencedirect.com/science/article/pii/S0092867413006454
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging
In this show, Dr. Kennedy discusses the work he is doing in Singapore where he is taking a very practical approach to try and show, without long and expensive trials, what interventions work for extending healthspan in humans. He covers his work with the government and the trials that he will be running.
Dr. Brain Kennedy is a Professor in the Departments of Biochemistry and Physiology at National University of Singapore and Director of the Centre for Healthy Ageing at the National University Health System. From 2010 to 2016, he was the President and CEO of the Buck Institute for Research on Aging. He remains a Professor at the Institute. Dr. Kennedy is internationally recognised for his research into the biology of aging and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human aging and its associated diseases. At National Univeristy of Singapore , Dr. Kennedy’s broader goals are to develop new interventions to target human aging and to validate their efficacy in humans. And ultimately, to create strategies to promote their widespread use.
TED TALK LINKS OF DR. KENNEDY
https://www.youtube.com/watch?v=E91fk6D0nwM Medical Revolution: Targeting aging directly | Brian Kennedy | TEDxOnBoard https://www.youtube.com/watch?v=iGSkpIRs6pc
Live Healthy Longer: Healthspan vs. Lifespan: Brian Kennedy at TEDxMaui 2013
Dr. Snyder is the Stanford W. Ascherman Professor and Chair, Department of Genetics and Director, Center for Genomics and Personalized Medicine at Stanford University. He is a leader in the field of functional genomics and proteomics. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated, and a high diversity of transcription factor binding occurs both between and within species. He has also pioneered the use of different state-of-the-art “omics” technologies as well as wearable devices for managing human health.
In this video, Dr. Snyder will discuss with us the benefits and methods of checking your health in depth when you are well so that you can quickly detect and react to issues as they arise, leading to better health outcomes.
Some resources for more information on Dr. Snyder: Dr. Synder Book: Genomics and Personalized Medicine: What Everyone Needs to Know https://amzn.to/3309oLD
Dr. Snyder’s Lab at Standford University http://med.stanford.edu/snyderlab.html
Professor Kaeberlein talks about the work that his lab is doing and how he views aging in this video. He also touches on how the message is being more widely received,
Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He is currently leading The Dog Aging project, a large multi-year trial to study the aging of companion dogs in a normal environment.
He has published nearly 200 papers in top scientific journals and has been recognized by several prestigious awards, including a Breakthroughs in Gerontology Award, and most recent GSA’s 2020 Robert W. Kleemeier Award
Professor Kaeberlein at University of Washington https://depts.washington.edu/mbwc/about/profile/matt-kaeberlein
Dog Aging Project. https://dogagingproject.zendesk.com/hc/en-us
In this episode Professor Kennedy covers lifestyle topics such as intermittent fasting and diet as well as explaining how mTOR may behave as we age. And I was happy to hear that alcohol is not all bad
Dr. Brain Kennedy is a Professor in the Departments of Biochemistry and Physiology at National University of Singapore and Director of the Centre for Healthy Ageing at the National University Health System. From 2010 to 2016, he was the President and CEO of the Buck Institute for Research on Aging. He remains a Professor at the Institute. Dr. Kennedy is internationally recognised for his research into the biology of aging and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human aging and its associated diseases. At National Univeristy of Singapore , Dr. Kennedy’s broader goals are to develop new interventions to target human aging and to validate their efficacy in humans. And ultimately, to create strategies to promote their widespread use.
TED TALK LINKS OF DR. KENNEDY
https://www.youtube.com/watch?v=E91fk6D0nwM Medical Revolution: Targeting aging directly | Brian Kennedy | TEDxOnBoard https://www.youtube.com/watch?v=iGSkpIRs6pc Live Healthy Longer: Healthspan vs. Lifespan: Brian Kennedy at TEDxMaui 2013
In this video Professor Kennedy covers lifestyle topics such as intermittent fasting and diet as well as explaining how mTOR may behave as we age. And I was happy to hear that alcohol is not all bad
Dr. Brain Kennedy is a Professor in the Departments of Biochemistry and Physiology at National University of Singapore and Director of the Centre for Healthy Ageing at the National University Health System. From 2010 to 2016, he was the President and CEO of the Buck Institute for Research on Aging. He remains a Professor at the Institute. Dr. Kennedy is internationally recognised for his research into the biology of aging and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human aging and its associated diseases. At National Univeristy of Singapore , Dr. Kennedy’s broader goals are to develop new interventions to target human aging and to validate their efficacy in humans. And ultimately, to create strategies to promote their widespread use.
TED TALK LINKS OF DR. KENNEDY
https://www.youtube.com/watch?v=E91fk6D0nwM Medical Revolution: Targeting aging directly | Brian Kennedy | TEDxOnBoard https://www.youtube.com/watch?v=iGSkpIRs6pc Live Healthy Longer: Healthspan vs. Lifespan: Brian Kennedy at TEDxMaui 2013
In this video Professor Kennedy elaborates on the drugs that he is using in his lab and in his trials, including alpha-ketoglutarate and spermidine. He also gives his views on NAD boosters and rapamycin.
Dr. Brain Kennedy is a Professor in the Departments of Biochemistry and Physiology at National University of Singapore and Director of the Centre for Healthy Ageing at the National University Health System. From 2010 to 2016, he was the President and CEO of the Buck Institute for Research on Aging. He remains a Professor at the Institute. Dr. Kennedy is internationally recognised for his research into the biology of aging and for his work to translate research discoveries into new ways of delaying, detecting, and preventing human aging and its associated diseases. At National Univeristy of Singapore , Dr. Kennedy’s broader goals are to develop new interventions to target human aging and to validate their efficacy in humans. And ultimately, to create strategies to promote their widespread use.
TED TALK LINKS OF DR. KENNEDY
https://www.youtube.com/watch?v=E91fk6D0nwM Medical Revolution: Targeting aging directly | Brian Kennedy | TEDxOnBoard https://www.youtube.com/watch?v=iGSkpIRs6pc Live Healthy Longer: Healthspan vs. Lifespan: Brian Kennedy at TEDxMaui 2013
Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai’s New Book - https://amzn.to/30MOsGT
Aging and Centenarian Studies : This is the part 3 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine.
Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award.
Dr. Barzilai’s New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process.
In this video Dr. Barzilai draws on his long experience working in the aging field to talk about some of the ways that we can improve our healthspan. His data provides some, perhaps, surprising advice on the ideal BMI and exercise with metformin.
Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation.
Disclosure: Some of the links provided are affiliate links. Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel!
Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later Dr. Barzilai’s New Book - https://amzn.to/30MOsGT
Aging and Centenarian Studies : This is the part 1 of our interview series with Dr. Nir Brazilai from Albert Einstein College of Medicine.
Dr. Barzilai is the founding director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. Dr. Barzilai discovered the first longevity gene in humans and has since discovered several others. In addition to his “longevity gene” research, Dr. Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He is also investigating the physical and mental declines associated with aging and how they affect longevity. He is the author of over 270 peer-reviewed papers and a recipient of numerous prestigious awards,including the recipient of the 2010 Irving S. Wright Award of Distinction in Aging Research and is the 2018 recipient of the IPSEN Longevity award.
Dr. Barzilai’s New Book - Age Later: Health Span, Life Span, and the New Science of Longevity In Age Later, the No.1 Best Sellers in Physiology section in Amazon, reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process.
In this interview Dr. Barzilai discusses his study of centenarians, what he learnt from that and how it can be applied. By studying centenarians and the mechanisms that keep them healthy he hopes to short cut years research and animal trials.
Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. It is the responsibility of you and your healthcare providers to make all decisions regarding your health. Products or services mentioned in this video are not a recommendation.
Disclosure: Some of the links provided are affiliate links. Although we may receive a small commission from the affiliate, the cost of the product for you will always be the same, or often discounted. Thank you for supporting our channel!
Our YouTube Channel is here Please visit us for more longevity and extended healthspan content.
In this podcast Dr. de Grey talks about his view on the latest rejuvenation technology.
Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process.
The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
https://amzn.to/37lBX7A
SENS Foundation
https://www.sens.org/
2013 paper on the 9 hallmarks of aging
https://www.sciencedirect.com/science/article/pii/S0092867413006454
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging
Our YouTube Channel is here Please visit us for more longevity and extended healthspan content.
In this podcast Dr. de Grey talks about his view of what the future of aging will look like
Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process.
The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
https://amzn.to/37lBX7A
SENS Foundation
https://www.sens.org/
2013 paper on the 9 hallmarks of aging
https://www.sciencedirect.com/science/article/pii/S0092867413006454
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging
Our YouTube Channel is here Please visit us for more longevity and extended healthspan content.
In this podcast Dr. de Grey talks about how the idea of an extended lifespan is being accepted by society and some of the implications of this.
Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process.
The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
https://amzn.to/37lBX7A
SENS Foundation
https://www.sens.org/
2013 paper on the 9 hallmarks of aging
https://www.sciencedirect.com/science/article/pii/S0092867413006454
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging
Our YouTube Channel is here Please visit us for more longevity and extended healthspan content.
In this podcast Dr. de Grey will talk about his view on the epigenetic aging clocks and their value in aging research.
Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process.
The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
https://amzn.to/37lBX7A
SENS Foundation
https://www.sens.org/
2013 paper on the 9 hallmarks of aging
https://www.sciencedirect.com/science/article/pii/S0092867413006454
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging
Our YouTube Channel is here Please visit us for more longevity and extended healthspan content.
In this podcast Dr. de Grey will talk about the hallmarks of aging that he defined and more specifically about the stiffening of the extra cellular matrix a hallmark that was in his original list but not the 2013 paper.
Dr. de Grey is a biomedical gerontologist and is the Chief Science Officer and co-founder of the SENS Research Foundation, an organization that is dedicated to combating the aging process.
The book by Dr. de Grey Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime
https://amzn.to/37lBX7A
SENS Foundation
https://www.sens.org/
2013 paper on the 9 hallmarks of aging
https://www.sciencedirect.com/science/article/pii/S0092867413006454
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
https://www.researchgate.net/publication/342138218_Stochastic_non-enzymatic_modification_of_long-lived_macromolecules_-_A_missing_hallmark_of_aging