Minding Memory: Recent Episodes
Michigan Medicine Podcast Network
Welcome to Minding Memory. In this podcast we discuss topics related to dementia research. This is an all-hands-on-deck moment for dementia research, and we have topics for both those new to the space as well as old pros. We start with some basics, like: What exactly is dementia? What are the different types of dementia? What is the TICS, if not a swarm of blood-sucking insects? But we also invite researchers on to discuss their interesting work to give you a glimpse at the questions, data, and methods moving the field forward.
Minding Memory is co-hosted by Matthew Davis and Donovan Maust. Matt and Donovan are Associate Professors and health services researchers at the University of Michigan. Matt’s PhD is in data science and Donovan is a psychiatrist. The Minding Memory podcast is part of the Center to Accelerate Population Research in Alzheimer’s (CAPRA) at the University of Michigan, supported by the National Institute on Aging at the National Institutes of Health. Additional support also comes from the Institute for Healthcare Policy and Innovation. The content of this podcast does not represent the views of the National Institutes of Health or the University of Michigan. Please consider subscribing to this podcast and make sure to check out our website at: https://capra.med.umich.edu/. On our website you’ll also find links to the center’s seminar series and data products created specifically for dementia research.
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
In this episode, Matt and Donovan talk with Dr. Jason H. Moore, Director of the Center for Artificial Intelligence Research and Education (CAIRE) and Chair of the Department of Computational Biomedicine at Cedars-Sinai Medical Center. Jason discusses the coming impact of artificial intelligence on a spectrum of Alzheimer’s disease and related dementia (ADRD) issues. We discuss how tools such as AI-powered chatbots may improve quality of life for people living with dementia (and their caregivers) and how AI may contribute in the future to diagnosis and treatment.
Faculty Bio: https://researchers.cedars-sinai.edu/Jason.Moore
Center for Artificial Intelligence Research and Education (CAIRE): https://www.cedars-sinai.edu/research/areas/caire.html
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
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In this episode of Minding Memory, Matt & Donovan speak with Dr. Joanne Spetz, the Brenda and Jeffrey L. Kang Presidential Chair in Healthcare Finance and Director of the Philip R. Lee Institute for Health Policy Studies at the University of California, San Francisco (UCSF). Joanne talks with Matt & Donovan about who makes up the professional workforce of people who provide dementia care and how these individuals play a critical role in the delivery of services. Joanne also discusses how different professional roles interact across setting of care. Lastly, Joanne introduces a new study she is working on with Donovan called the National Dementia Workforce Study (NDWS) that will be surveying a large group of clinicians who provide care for people living with dementia.
Faculty Bio: https://profiles.ucsf.edu/joanne.spetz
Article Referenced in Podcast:
Candon M, Bergman A, Rose A, Song H, David G, Spetz J. The Relationship Between Scope of Practice Laws for Task Delegation and Nurse Turnover in Home Health. J Am Med Dir Assoc. 2023 Nov;24(11):1773-1778.e2. doi: 10.1016/j.jamda.2023.07.023. Epub 2023 Aug 24. PMID: 37634547; PMCID: PMC10735229.
Previous Minding Memory Episodes on Dementia & Family Caregiving:
S1Ep9: Caregiving for individuals with Dementia (with Amanda Leggett)
S1Ep10: What is it like to be a Caregiver for a Person Living with Dementia? (with Peggy Arden)
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
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In this episode of Minding Memory, Matt & Donovan speak with Dr. Lisa Barnes, the Alla V. and Solomon Jesmer Professor of Gerontology and Geriatric Medicine, Department of Neurological Sciences and Associate-Director of the Rush Alzheimer’s Disease Center at Rush University. Dr. Barnes talks with Matt & Donovan about racial disparities in Alzheimer’s disease dementia and several obstacles that have impeded our understanding of race and dementia.
Faculty Profile: https://www.rushu.rush.edu/faculty/lisa-barnes-phd
RADC Resource Sharing Hub: https://www.radc.rush.edu/
Article Referenced in Podcast:
Barnes LL. Alzheimer disease in African American individuals: increased incidence or not enough data? Nat Rev Neurol. 2022 Jan;18(1):56-62. doi: 10.1038/s41582-021-00589-3. Epub 2021 Dec 6. PMID: 34873310; PMCID: PMC8647782.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
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In 2009, the Health Information Technology for Economic and Clinical Health Act, wow, that's a mouthful, more commonly known as the HITECH Act, spent billions to promote the uptake of electronic health records by US hospitals. Fast forward more than a decade later, and now approximately four out of five healthcare institutions have electronic health record systems in place that integrate clinical notes, test results, medications, diagnostic images, et cetera. The adoption of EHR systems into healthcare introduces new and exciting opportunities to extract information that can be used to augment other types of data for research. As you might imagine though, it can be tricky to pull out meaningful information from the text of clinical notes. In this episode, we'll speak with a University of Michigan researcher, Dr. Vinod Vydiswaran, who's been developing methods to identify dementia from EHR data.
Faculty Profile: https://medicine.umich.edu/dept/lhs/vg-vinod-vydiswaran-phd
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
The population of older adults living with dementia is expected to swell to nearly 14 million by 2050 and is estimated to cost the US economy more than 500 billion each year. In the absence of a cure for Alzheimer's disease, the primary cause of dementia, there's interest in understanding modifiable risk factors. In theory, getting a handle on the modifiable risk factors for dementia, would enable public health efforts to reduce cognitive decline in dementia at the population level. We've come a long way in understanding the risk factors for Alzheimer's disease and other related dementias. However, there's still work to be done. In this episode, we'll speak with Dr. Josh Ehrlich, a researcher at the University of Michigan, who has examined vision impairment as a risk factor for dementia.
Joshua Ehrlich Faculty Profile: https://medicine.umich.edu/dept/ophthalmology/joshua-r-ehrlich-md-mph
Articles Referenced in the Podcast:
Ehrlich JR, Goldstein J, Swenor BK, Whitson H, Langa KM, Veliz P. Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US. JAMA Neurol. 2022 Jun 1;79(6):623-626. doi: 10.1001/jamaneurol.2022.0723. Erratum in: JAMA Neurol. 2022 Jun 1;79(6):634. PMID: 35467745; PMCID: PMC9039828.
New York Times Article, July 2022: New Dementia Prevention Method May Be Behavioral, Not Prescribed
Lancet Commission on Dementia Prevention, Intervention, and Care (2020)
Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020 Aug 8;396(10248):413-446. doi: 10.1016/S0140-6736(20)30367-6. Epub 2020 Jul 30. Erratum in: Lancet. 2023 Sep 30;402(10408):1132. PMID: 32738937; PMCID: PMC7392084.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
According to an estimate published in 2015, the global prevalence of dementia was projected to nearly triple between 2015 and 2050, growing from 46 million to over 130 million people globally. And of that worldwide share, 70% of those with dementia will be in low- and middle-income countries. Tackling and ideally preventing dementia requires a global perspective. In this episode, Matt & Donovan speak with Dr. Lindsay Kobayashi, a faculty member in the Department of Epidemiology at the University of Michigan School of Public Health whose research focuses on the social epidemiology of aging from a global perspective. Dr. Kobayashi introduces us to a whole new world of data available to help researchers tackle dementia as a global challenge.
Lindsay Kobayashi Faculty Profile: https://sph.umich.edu/faculty-profiles/kobayashi-lindsay.html
Article referenced in this episode:
Kobayashi LC, Gross AL, Gibbons LE, Tommet D, Sanders RE, Choi SE, Mukherjee S, Glymour M, Manly JJ, Berkman LF, Crane PK, Mungas DM, Jones RN. You Say Tomato, I Say Radish: Can Brief Cognitive Assessments in the U.S. Health Retirement Study Be Harmonized With Its International Partner Studies? J Gerontol B Psychol Sci Soc Sci. 2021 Oct 30;76(9):1767-1776. doi: 10.1093/geronb/gbaa205. PMID: 33249448; PMCID: PMC8557836.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
Over thirty percent of individuals living with dementia living in the US each year die either of or with dementia – and almost half of those enrolled in hospice have dementia. As with so many other types of healthcare, there are disparities in both who enrolls in hospice as well as the type of care these individuals receive after enrollment. In this episode, Matt & Donovan talk with Dr. Lauren Hunt from UCSF, an expert in hospice care for persons living with dementia, about dementia at the end of life.
Lauren Hunt Faculty Profile: https://profiles.ucsf.edu/lauren.hunt
Article referenced in this episode:
Hunt LJ, Gan S, Smith AK, Aldridge MD, Boscardin WJ, Harrison KL, James JE, Lee AK, Yaffe K. Hospice Quality, Race, and Disenrollment in Hospice Enrollees With Dementia. J Palliat Med. 2023 Aug;26(8):1100-1108. doi: 10.1089/jpm.2023.0011. Epub 2023 Apr 3. PMID: 37010377; PMCID: PMC10440673.
Article on identifying disenrollment in claims data:
Hunt LJ, Gan S, Boscardin WJ, Yaffe K, Ritchie CS, Aldridge MD, Smith AK. A national study of disenrollment from hospice among people with dementia. J Am Geriatr Soc. 2022 Oct;70(10):2858-2870. doi: 10.1111/jgs.17912. Epub 2022 Jun 7. PMID: 35670444; PMCID: PMC9588572.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
Extreme weather and weather-related disasters are becoming more and more common. Unfortunately, disaster related disruptions in healthcare tend to affect the most vulnerable of populations – including older adults living with cognitive impairment. In this episode, Matt & Donovan speak with University of Michigan faculty member, Sue Anne Bell, about how healthcare disruption due to a disaster can affect the population of older adults living with dementia.
Sue Anne Bell Faculty Link: https://nursing.umich.edu/faculty-staff/faculty/sue-anne-bell
Article referenced in podcast:
Bell SA, Miranda ML, Bynum JPW, Davis MA. Mortality After Exposure to a Hurricane Among Older Adults Living With Dementia. JAMA Network Open. 2023 Mar 1;6(3):e232043. doi: 10.1001/jamanetworkopen.2023.2043. PMID: 36881412; PMCID: PMC9993175.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
In this episode of Minding Memory, we dive into the newest FDA-approved drug to treat Alzheimer’s – Lecanemab – with Ohio State University stroke neurologist Jim Burke. Dr. Burke discusses the benefits and drawbacks of the new Alzheimer’s drug and also the paradigm shift of how people (clinicians, patients, and the general population) are thinking about these news Alzheimer’s medications.
Jim Burke Faculty Profile: https://wexnermedical.osu.edu/find-a-doctor/james-burke-md-128794
Article referenced in podcast: Burke JF, Richard S, Langa KM, Albin RL, Kotagal V. Lecanemab: Looking Before We Leap. Neurology. 2023 Jul 21: doi: 10.1212/WNL.0000000000207505. Epub ahead of print. PMID: 37479527.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
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In this episode, Donovan & Matt talk with health services researcher Betsy White from Brown University about a unique new resource for researchers called the Long-Term Data Cooperative, a provider-led data sharing collaboratory that puts together nursing home EHR data from EHR vendors that can be linked to Medicare claims. This powerful tool is made available to researchers through an online application process.
This episode references the RFA for the Real-World Data Scholars Program, which is now expired. However, Minding Memory listeners can find out about upcoming opportunities or future RFAs by emailing RWDScholars@brown.edu.
Betsy White Faculty Profile: https://vivo.brown.edu/display/ewhite14
Long Term Care Data Cooperative: https://www.ltcdatacooperative.org/Pages/default.aspx
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
In this episode, Matt & Donovan speak with University of Michigan School of Public Health Professor, Dr. J. Scott Roberts, who investigates the psychological and behavioral impact of genetic risk disclosure for Alzheimer's disease.
In addition to being a professor in the Health Behavior & Health Education department at the School of Public Health, Dr. Roberts is also a core lead of the Michigan Alzheimer’s Disease Center. Dr. Roberts’s research interests focus on the process and impact of risk assessment and disclosure for adult-onset disorders, as well as the ethical, legal, and social implications of advances in genomic science & technology.
Faculty Profile: https://sph.umich.edu/faculty-profiles/roberts-j.html
Michigan Alzheimer’s Disease Center (MDAC): https://alzheimers.med.umich.edu/
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
In this episode, Matt & Donovan speak with a health economist, Dr. Lauren Nicholas, whose research investigates how missing a single credit card payment may be a very early indicator of a cognitive issue. Dr. Nicholas is an associate professor in the department of Health Systems Management & Policy at the University of Colorado School of Public Health and has published several studies that examined on how a financial issue might be among the first signs of cognitive decline.
Lauren Nicholas Faculty Profile: https://coloradosph.cuanschutz.edu/resources/directory/directory-profile/Nicholas-Lauren-UCD6003780837
Article referenced in this episode:
Nicholas LH, Langa KM, Bynum JPW, Hsu JW. Financial Presentation of Alzheimer Disease and Related Dementias [published correction appears in JAMA Intern Med. 2021 Feb 1;181(2):296]. JAMA Intern Med. 2021;181(2):220-227. doi:10.1001/jamainternmed.2020.6432
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
In this episode, Donovan & Matt speak with Geoffrey Hoffman, a faculty member and researcher at the University of Michigan School of Nursing. Dr. Hoffman discusses the transition to the role of caregiver for partners of persons diagnosed with dementia – and the unique emotional burden and stress that they undertake. Dr. Hoffman also discusses using the Health & Retirement Study (HRS) to better explore the emotional stress and onset of depression in caregivers.
Geoff Hoffman Faculty Profile: https://nursing.umich.edu/faculty-staff/faculty/geoffrey-j-hoffman
Article Referenced in this Episode
Harris ML, Errickson J, Ha J, Hoffman GJ. Depressive Symptoms and Caregiving Intensity Before and After Onset of Dementia in Partners: A Retrospective, Observational Study. Med Care. 2022;60(11):844-851. doi:10.1097/MLR.0000000000001771 [PMID: 36038513]
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
In this episode we’ll speak with Dr. Julie Bynum who was the senior author on a recent study that examined how the likelihood of receiving a diagnosis of dementia has changed over the last decade or so. We’ll discuss what this might mean clinically and what researchers that rely on Medicare data should take-away from this finding. We also will talk in general about the various approaches that exist for identification of dementia in Medicare billing data.
Julie Bynum Faculty Profile: https://medicine.umich.edu/dept/dgpm/julie-bynum-md-mph
Article Referenced in this Episode
Davis MA, Chang CH, Simonton S, Bynum JPW. Trends in US Medicare Decedents' Diagnosis of Dementia From 2004 to 2017. JAMA Health Forum. 2022 Apr 1;3(4):e220346. doi: 10.1001/jamahealthforum.2022.0346. PMID: 35977316
Resources:
The Bynum-Standard 1-Year Algorithm for identifying Alzheimer’s Disease and Related Dementias (ADRD) in Medicare Claims data.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
In this episode we discuss what’s known about the association between personality type and cognitive function. Further, the idea of resilience—or what protects the cognition of individuals with a high level of neuropathology associated with cognitive decline—might have important implications for dementia prevention. Our guests are Dr. Eileen Graham and Dr. Dan Mroczek. Drs. Graham and Mroczek are both faculty at Northwestern University with interests in how personality factors influence physical and cognitive health over the life course.
Eileen Graham Faculty Profile
Dan Mroczek Faculty Profile
Article References in Podcast:
Graham EK, James BD, Jackson KL, et al. Associations Between Personality Traits and Cognitive Resilience in Older Adults. J Gerontol B Psychol Sci Soc Sci. 2021;76(1):6-19. doi:10.1093/geronb/gbaa135
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
Health data analysts are an elusive bunch in the wild. While we see their names periodically show up as middle authors on manuscripts or in the Acknowledgement section they work largely behind the scenes; yet they play a vital role in conducting research that use large data. In this episode we speak with several health data analysts to better understand the role they play in research and, for all the researchers out there, discuss how to make the process as smooth as possible when working with an analyst.
The transcript for this episode can be found here.
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
This week we feature a recent study by Katherine Ornstein and colleagues that was published in the Journal of the American Geriatrics Society. Dr. Ornstein studies family caregiving and the home-based clinical care. The study used Medicare claims linked to the National Health and Aging Trends Study to estimate the degree to which people living with dementia use health services from home. We’ll discuss what exactly home-based health services are (and how they are typically categorized) and discuss the role these services are expected to play for people living with dementia.
The transcript for this episode can be found here.
Dr. Ornstein Faculty Profile: https://nursing.jhu.edu/faculty_research/faculty/faculty-directory/katherine-ornstein
Article Referenced in Podcast:
Ornstein KA, Ankuda CK, Leff B, et al. Medicare-funded home-based clinical care for community-dwelling persons with dementia: An essential healthcare delivery mechanism. J Am Geriatr Soc. 2022;70(4):1127-1135. doi:10.1111/jgs.17621
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
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For older adults living with dementia, cognitive impairment can lead to susceptibility to fraudulent activities. In this episode we’ll discuss with Dr. Duke Han from the Keck School of Medicine at USC what’s known about the intersection of aging, cognition, and susceptibility to scams.
The transcript for this episode can be found here.
Duke Han PhD Faculty Profile: https://profiles.sc-ctsi.org/duke.han
Additional Information:
The susceptibility to scams scale developed by James, Boyle, & Bennett (2014)* is a 5-item self-report measure in which participants rated their agreement using a 7-point Likert scale (strongly agree to strongly disagree) for the following statements:
- I answer the phone whenever it rings, even if I do not know who is calling.
- I have difficulty ending a phone call, even if the caller is a telemarketer, someone I do not know, or someone I did not wish to call me.
- If something sounds too good to be true, it usually is.
- Persons over the age of 65 are often targeted by con-artists.
- If a telemarketer calls me, I usually listen to what they have to say.
Resources for older adults (and non-older adults) to report fraud:
U.S. Senate Special Committee on Aging: Fraud Hotline | Senate Committee On Aging
Hotline: 1-855-303-9470 (open weekdays from 9 a.m. to 5 p.m. Eastern Time)
Internet Crime Compliant Center (IC3): https://Ic3.gov/
Federal Trade Commission: Reportfraud.ftc.gov/
James BD, Boyle PA, Bennett DA. Correlates of susceptibility to scams in older adults without dementia. J Elder Abuse Negl*. 2014;26(2):107-122. doi:10.1080/08946566.2013.821809
CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
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Causes of death were reclassified by the CDC to include contributing factors such as dementia. These changes resulted in dementia jumping up from the 8th cause of death in 2000 to the 6th cause of death in 2018 (and the 5th cause of death among older adults). In this episode we’ll talk with Dr. Bryan James from Rush University about dementia as a cause of death (versus contributing factor).
DISCLAIMER: In this episode we are going to be talking about research on dementia and mortality. Because research transcribes human experiences into cold numbers it tends to objectify real human conditions such as death. This can come off as insensitive if it hits close to home. Therefore, if you or someone you care for is a person living with Alzheimer’s disease you may not want to listen to this episode.
The transcript for this episode can be found here.
Additional Information:
Bryan James, PhD Faculty Profiles: https://www.rushu.rush.edu/faculty/bryan-d-james-phd
Epidemiology Counts Podcast (Co-Hosted by Bryan James): https://serepidemiologycounts.blubrry.net/
Article referenced in episode:
James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K, Bennett DA. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014;82(12):1045-1050. doi:10.1212/WNL.0000000000000240 https://pubmed.ncbi.nlm.nih.gov/24598707/
- Rush Aging & Memory Project: https://www.rushu.rush.edu/research/departmental-research/memory-and-aging-project
- Rush Religious Orders Study: https://www.rushu.rush.edu/research/departmental-research/religious-orders-study
- CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Hosted on Acast. See acast.com/privacy for more information.
If you’re new to dementia research, you’ll soon come to find that most research papers on dementia start off something like this: “In the United States there are 5.8 million individuals living with dementia and this is expected to increase to 13 million by 2015. . . .” In this episode we discuss the study on dementia prevalence that has been cited thousands of times with one of the authors. Dr. Jennifer Weuve from Boston University joins us today. We also talk more broadly about what makes a research paper highly citable in general.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
In our last episode we talked about caregivers for individuals living with dementia. In this second part of our series on caregivers we’ll get to know someone with lived experience. We’re joined in this episode by Peggy Arden whose husband has Alzheimer’s disease. Peggy has graciously agreed to offer us a behind the scenes look at the ups and downs of being a dementia caregiver.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
Individuals living with dementia require care that is often delivered by family and friends. This episode is devoted to discussing some of the unique aspects of dementia caregiving. Our guest today is Dr. Amanda Leggett. Dr. Leggett is a Research Assistant Professor in the Department of Psychiatry here at the University of Michigan. Her research, funded by the National Institutes of Health, is focused on issues related to dementia caregiving. She has interviewed over a hundred patients with dementia and their caregivers.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
- Michigan Center on the Demography of Aging: https://micda.isr.umich.edu/
- The 36 Hour Day (Book): https://jhupbooks.press.jhu.edu/title/36-hour-day
Resources for Caregivers:
- U-M Turner Center (in Ann Arbor): https://medicine.umich.edu/dept/geriatrics-center/community-programs/turner-senior-resource-center
- Alzheimer Associations: https://www.alz.org/help-support/caregiving
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
One of the richest data sources available to study cognition and aging is the Health and Retirement Study (HRS). This nationally representative survey includes questions to help assess cognition, but many researchers may use this data without actually knowing the questions behind the variables—don’t be That Guy! (or Gal!) Listen to Dr. Lindsay Ryan, an HRS team member, coach Matt as he administers the Telephone Interview for Cognitive Status (TICS) to Donovan, who is surprisingly good at recalling types of birds.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
- Health and Retirement Study (HRS): https://hrsonline.isr.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
While there are some FDA-approved medications for dementia, more individuals living with dementia are actually prescribed psychotropic medications. In this episode, Donovan introduces Matt to the concept of the behavioral and psychological symptoms of dementia, which are just as much part of dementia as the memory loss—and are probably a big reason for all this other prescribing.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
- Article discussed in this episode: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435346/ Maust DT, Strominger J, Bynum JPW, et al. Prevalence of Psychotropic and Opioid Prescription Fills Among Community-Dwelling Older Adults With Dementia in the US. JAMA. 2020;324(7):706–708. doi:10.1001/jama.2020.8519
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Our guest in this episode is Dr. Sara Adar. She is an associate professor at the University of Michigan School of Public Health in the department of epidemiology. Dr. Adar was the senior author on a study titled “Long-term community noise exposure in relation to dementia, cognition, and cognitive decline in older adults” that was published in the journal Alzheimer’s & Dementia. The study used data from the Chicago Health and Aging Project to examine the association between exposure to community noise and cognitive impairment. We talk with her about how exposure to noise affects cognition.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
- Article discussed in this episode: https://pubmed.ncbi.nlm.nih.gov/33084241/ Weuve, J., D'Souza, J., Beck, T., Evans, D. A., Kaufman, J. D., Rajan, K. B., Mendes de Leon, C. F., & Adar, S. D. (2021). Long‐term community noise exposure in relation to dementia, cognition, and cognitive decline in older adults. Alzheimer's & Dementia, 17(3), 525-533. DOI: 10.1002/alz.12191
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
Often research studies consider dementia as either present or absent, while others specify particular types of dementia. For example, what exactly is frontotemporal dementia? In this episode, we talk with Dr. Henry (Hank) Paulson, who directs the Michigan Alzheimer’s Disease Center, to introduce listeners to the most common types of dementia and hear about some of their defining features. For those of you without clinical backgrounds, consider this your crash course on the types of dementia.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
- Michigan Alzheimer’s Disease Center: https://alzheimers.med.umich.edu/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
In this episode we continue our discussion of the implications of the approval of the Alzheimer’s drug Aduhelm (generic name Aducanumab). Our guest this week is Professor Nicholas Bagley. Bagley is a professor of law at the University of Michigan Law School and a contributing writer to the Atlantic. Recently he wrote an article titled “The Drug that Could Break American Health Care” that discusses some of the broader (unintended) consequences of the approval of Aducanumab. In this episode we discuss some of the broader cost implications of the new drug.
PRODUCER’S NOTE: Since the recording of this interview, Medicare officials have announced the largest ever dollar-amount rate hike for Part B coverage citing the need to build contingency reserves to potentially cover the Alzheimer’s drug, Aduhelm. Professor Bagley discusses the concern of the cost of Aduhelm to the US Healthcare System in this Minding Memory episode.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
- Atlantic Article – The Drug that Could Break American Healthcare by Nicholas Bagley & Rachel Sachs: https://www.theatlantic.com/ideas/archive/2021/06/aduhelm-drug-alzheimers-cost-medicare/619169/
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
Aducanumab is a new drug designed to remove amyloid in the brain. Following an accelerated process, the Food and Drug Administration approved Aducanumab as a treatment for Alzheimer’s disease despite (what many experts feel) little evidence of effectiveness. In this episode we discuss the approval of Aducanumab with Dr. Jason Karlawish from the University of Pennsylvania and talk about what it could mean for drug discovery going forward.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu/
- The Problem of Alzheimer’s by Jason Karlawish: https://us.macmillan.com/books/9781250218742
- Jason Karlawish Website: jasonkarlawish.com
- FDA Aducanumab Approval Press Release (June 2021): https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-drug
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
In this episode we talk with Dr. Ken Langa about the implications of identification of “preclinical” Alzheimer’s disease (situations where individuals may have biological signs of Alzheimer’s but no symptoms). Ken is a leading dementia researcher and our discussion focuses on an article he published called “Preclinical Alzheimer Disease – Early Diagnosis or Overdiagnosis” that was published in JAMA Internal Medicine. In his article co-authored with Dr. Jim Burke, he brings up some of the potential indirect effects of early detection.
The transcript for this episode can be found here.
RELATED LINKS:
- CAPRA Website: http://capra.med.umich.edu/
- National Poll on Healthy Aging: https://www.healthyagingpoll.org/
- Article discussed in this episode: https://pubmed.ncbi.nlm.nih.gov/31282928/ Langa, Kenneth M., and James F. Burke. "Preclinical Alzheimer disease—early diagnosis or overdiagnosis?." JAMA Internal Medicine 179.9 (2019): 1161-1162.
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.
Welcome to the podcast! In this episode we introduce ourselves and provide an overview of the Minding Memory Podcast. This podcast is supported by the Center to Accelerate Population Research in Alzheimer’s (CAPRA) at the University of Michigan. Our guest this week is Dr. Julie Bynum. Julie is the director of CAPRA and we talk briefly about what the NIH-funded research center is and how to get involved.
The transcript for this episode can be found here.
Related Links:
- CAPRA Website: http://capra.med.umich.edu
You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.
Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.