Live Longer World: Recent Episodes
Aastha Jain
The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. Live Longer World takes you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future.
https://www.livelongerworld.com/
Stephanie Seneff is the pioneer in raising concerns around glyphosate, a chemical and active ingredient in RoundUp and other pesticides, which has practically infiltrated our food system, water bodies, and soil. Glyphosate has been linked to several diseases including liver disease, autoimmunity, neurological disorders, reproductive issues, microbiome problems, and more.Dr. Stephanie Seneff has spent 10+ years researching glyphosate’s harmful impact on our health, and documented her findings in her book Toxic Legacy: How the Weedkiller Glyphosate is Destroying our Health and the Environment.More recently, Stephanie has been doing research on deuterium (a hydrogen isotope in the body) and how glyphosate can cause an excess of deuterium, potentially leading to cancer and other health consequences. Glyphosate is affecting each one of us. It’s worth paying attention to this toxic chemical.Episode Show Notes: https://livelongerworld.com/p/sseneffFind me (Aastha) on X: https://x.com/aasthajsDR. STEPHANIE SENEFF LINKS:Website: https://stephanieseneff.net/X: https://x.com/stephanieseneffBook: https://www.amazon.com/Toxic-Legacy-Stephanie-Seneff/dp/1603589295/AASTHA, LIVE LONGER WORLD:X: https://x.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajsTIMESTAMPS:0:00 Autism in children, vaccines, glyphosate2:30 Aluminum and fluoride in water3:47 Glyphosate in our food and its toxicity6:05 Celiac’s link to glyphosate8:25 Glyphosate impacting collagen in our bodies12:55 Soil regeneration after glyphosate15:24 Breaking down glyphosate in our waterways16:36 Glyphosate causing sulfate deficiency; cruciferous veggies18:43 Sulfate powers bioelectricity in our cells; Gerald Pollack21:23 Avoid sunscreen?22:25 Deuterium and its toxicity25:20 How Stephanie started looking at Deuterium26:36 Low deuterium water good for health?29:25 Excess deuterium causing cancer30:52 Stephanie’s wild theory on curing cancer35:19 What else causes increase in deuterium35:38 Glyphosate in rain water36:25 PSCSK9 inhibitors harmful with glyphosate38:49 Solutions to avoid glyphosate42:23 U.S. stopped Mexico banning glyphosateEpisode Show Notes: https://livelongerworld.com/p/sseneff
This is the first of several interviews Michael Levin and I will do with significant people in the history of developmental bioelectricity.
Richard Nuccitelli is a legend, having invented (with Lionel Jaffe, in 1974) the Vibrating Probe - a technique that allowed the non-invasive sensing of ion currents around living tissues. This is about a ~1 hour conversation in which he talks about his background, the history of the field, and his current clinical work on the bioelectrics of cancer.Episode Show Notes: https://livelongerworld.com/p/rnuccitelli
Find me: https://twitter.com/aasthajsBACKGROUND:In 2022, I interviewed Dr. Michael Levin on his work on bioelectricity in cells and how that has the potential to solve cancer and aging. Since then, Mike has also appeared on Lex Fridman and many other podcasts talking about his revolutionary work.Amongst all the podcasts I did, Mike’s work struck me as profound yet underappreciated. The field of biology has focused on the DNA and the relevance of the electric currents in our cells is not appreciated. Yes, the electrical energy powering our cells is what keeps us alive! Earlier this year, I decided to dive deeper into bioelectricity. I’m starting by exploring the history of the field in conjunction with Michael Levin. We’re doing a series of interviews talking to scientists in the field to understand the origins of the field, bottlenecks, progress so far, and what the future could look like.Today's interview is the first in the series with Dr. Richard Nuccitelli.TIMESTAMPS:0:00 Intro to History of Bioelectricity Series1:09 How Rich got interested in bioelectricity4:34 Bioelectrics didn't make it to biology literature7:55 Vibrating probe use cases10:20 Bioelectrics in 1970s13:37 Why is bioelectrics underrated?22:50 Field progression29:02 Ultra high voltage in treating cancer39:00 Understanding significance of bioelectrics from 1900s44:40 Working with Lionel Jaffe50:27 How Mike entered bioelectrics54:02 Criticism received by bioelectrics?57:04 Missing technology to advance bioelectrics1:00:52 Electrical patterns in cells with age1:03:12 Image of electrics in organismsAASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajsMichael Levin: https://twitter.com/drmichaellevinRichard Nuccitelli: https://www.linkedin.com/in/nuccitelli/ Episode Show Notes: https://livelongerworld.com/p/rnuccitelli
Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8?si=WrQ_iI8ABbG6eibm
Dr. Mikkael Sekeres is the author of the book The Drugs and FDA. He served as the chair of the Oncology Drugs Advisory Committee of the FDA, and was on the jury for the controversial trial of the breast cancer drug Avastin.We discuss:- The history of the FDA,- The trial of Avastin which got FDA approval in 2008 and revoked in 2011- FDA's funding mechanisms- FDA ties to big pharma- What can be improved about the FDA and the criticisms it receives
Episode Show Notes: https://livelongerworld.com/p/msekeresTIMESTAMPS:0:00 Surprising finding about the FDA2:38 Why did the FDA get established in 1938?11:48 1962 turning point in the FDA & Thalidomide19:57 Kennedy’s efficacy act on drugs approval25:40 FDA’s accelerated approval; HIV & AIDS33:23 Avastin breast cancer drug controversy41:13 Why was Avastin trial contentious?45:23 Genentech’s argument50:00 Media reaction53:21 FDA funded by big pharma56:39 FDA vs. patient activist groups59:50 Opioid crisis1:03:30 Does the FDA go against advisory committee?CONNECT WITH AASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajsDR. MIKKAEL SEKERES LINKS:Website: https://www.mikkaelsekeres.com/Twitter: https://twitter.com/MikkaelSekeres
Book: https://www.amazon.com/Drugs-FDA-Safety-Efficacy-Publics/dp/0262047314If you enjoyed the episode, please share it and leave a rating. Best, Aastha.
Dr. Jennifer Garrison is a an Assistant professor at the Buck Institute for research on aging where she studies women's reproductive aging. In today’s conversation we discussed menopause and it’s effect on women’s health, hormone replacement therapy, and how increasing the number of quality eggs a woman has at age 40 by just 1% can be a game changer.
Episode Show Notes: https://livelongerworld.com/p/jgarrison
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.com/Find me (Aastha) on Twitter: https://twitter.com/aasthajs
DR. JENNIFER GARRISON LINKS:Lab: http://garrisonlab.com/ Donate to her research: https://gcrle.org/CONNECT WITH AASTHA, LIVE LONGER WORLD:Twitter: https://twitter.com/aasthajsNewsletter: https://livelongerworld.com/Instagram: https://www.instagram.com/aasthajs/Airchat: https://www.getairchat.com/aasthajs
TIMESTAMPS:00:00 Intro1:38 Jennifer Garrison Intro2:32 Ovarian aging & health risks5:23 Progression of Ovarian aging8:49 Menopause and negative health effects10:34 Hypothalamus & Mind body communication14:40 Reproductive & Equality Initiatives18:21 Biological Clock for Reproductive aging20:20 Tweaking hormonal cues22:07 Number of eggs vs. Quality of eggs25:00 Genetics in ovarian aging26:21 Understanding family history27:39 Evolutionary benefit to Menopause?32:33 Hormone Replacement Therapy (HRT) & its benefits38:28 Narrow window for HRT40:08 Perimenopause42:56 Women’s health funding45:14 Average age girls start menstruating is declining49:10 PCOS52:42 Athletes and irregular cycles56:36 Individualized menopause symptoms1:00:38 Exercise and ovarian aging1:02:00 Support Jennifer's work
Episode Show Notes: https://livelongerworld.com/p/jgarrisonPOPULAR EPSIODES:- Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA- Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg- Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8- Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8- Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.
Aging is universal. Let's unite in this fight.Stay in good health - Aastha.
Dr. Geoffrey West is the author of the bestselling book Scale, the Universal Laws of Life Growth and Death in Organisms, cities and Companies. He is a physicist who got fascinated by the field of aging and longevity and asked the question of why we live as long as we do and no longer. In today's episode, we dive into his research on the scaling laws in biology and longevity.
Episode Show Notes: https://livelongerworld.substack.com/p/gwestFind the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajs
DR. GEOFFREY WEST LINKS:Profile: https://www.santafe.edu/people/profile/geoffrey-westBook: https://amzn.to/3Xtl7wUCONNECT WITH AASTHA, LIVE LONGER WORLD:
Newsletter: https://livelongerworld.substack.com/
Twitter: https://twitter.com/aasthajs
Instagram: https://www.instagram.com/aasthajs/
Airchat: https://www.getairchat.com/aasthajs
TIMESTAMPS:1:35 Context on Dr. West's book Scale9:00 Networks in biology & cities22:50 Scaling laws in longevity
32:33 Upper limit to human age?
39:08 Quantifying Caloric restriction
41:52 Metabolism & Body temperature
49:05 Scaling laws in age-related damage
56:35 Scaling body sizes across species
1:01:38 Scaling laws in drug dosage (LSD & Elephants)
1:11:06 Drug dosage in children (Tylenol & babies)
1:13:44 Vaccine dosage scaling laws
1:17:51 Sleep & Aging in different organisms
1:31:22 Early stimulation for child development
1:36:35 Fasting, meal frequency & digestive time
1:39:10 Sleep demands with work & physical activity
1:43:40: Scaling laws in cities, companies & universities
2:02:00 Outro
POPULAR EPSIODES:
Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA
Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg
Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8
Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8
Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, or signing up as a premium member.Aging is universal. Let's unite in this fight.Stay in good health - Aastha.
All platforms / Episode Transcript: https://livelongerworld.substack.com/p/saustad
Dr. Steven Austad is a professor in the Healthy Aging department at the University of Alabama and also scientific director of the American Federation for Aging research. He has a fascinating entry into the world of aging research - it all began with training lions!
There are many open questions on the caloric restriction research for enhancing longevity and we dive into that. Further, a lot of Dr. Austad’s work focuses on what long-lived animal species can teach us about living longer and healthier lives. His lab works on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover aging treatments. He also tries to uncover the mysteries around why men and women respond differently to longevity therapeutics.
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajz
DR. STEVEN AUSTAD LINKS:
Website: https://www.stevenaustad.com/
Twitter: https://twitter.com/StevenAustad
Faculty page: https://www.uab.edu/cas/biology/people/faculty/steven-n-austad
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/aasthajz
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/aasthajz/
TIMESTAMPS:
0:00 Training lions
7:15 Learning from Long-lived species
9:55 Bowhead whales live 200 years
12:55 House sparrows & longevity
14:40 Study "successful" animals
18:10 Naked Mole Rats
20:45 What do bowhead whales die from?
26:05 Why do ocean animals live longest?
31:05 Beyond Caloric Restriction
36:00 Intermittent Fasting & Circadian Rhythm
42:40 Caloric Restriction for Healthy people?
46:24 Will coffee shorten your life?
49:43 The Blue Zone Myth
55:50 Young Blood, I can't get you of out my Mind
1:00:26 Hormones & Health (Growth Hormones for longevity?)
1:05:18 Sex differences in longevity
Episode Show Notes: https://livelongerworld.substack.com/p/saustad
POPULAR EPSIODES:
-
Richard Miller on Longevity Supplements: https://youtu.be/42PzfNs9egA
-
Matt Kaeberlein on Rapamycin: https://youtu.be/BL67DhNepfg
-
Michael Levin on Bioelectric Signals for Longevity: https://youtu.be/XboYI_wxDr8
-
Nir Barzilai on Metformin & Centenarians: https://youtu.be/YlkBE8N7sl8
-
Morgan Levine on Epigenetic Clocks: https://youtu.be/am3YKiTpCHo
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom2
Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.
This is Part 2 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the ketogenic diet for exercise performance, keto for women & children, Dom's diet & supplement routine + more! Hope you enjoy the episode!
Part 1 with Dom on Ketogenic diets for Brain Health and Longevity: https://livelongerworld.substack.com/p/dom1
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/aasthajz
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DOM D'AGOSTINO LINKS:
KetoNutrition: https://ketonutrition.org/
Website: https://linktr.ee/Domdagostino
Twitter: https://twitter.com/DominicDAgosti2
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/aasthajz
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/aasthajz/
TIMESTAMPS:
0:00 Ketogenic diet for muscle performance
0:50 Dom’s supplements & modified keto diet
3:20 Keto, NAD+, NMN 7:12 Biomarkers tracked by Dom
9:30 LDL, Triglycerides, Fatty Foods & Keto diet
14:15 Dom’s routine & supplements
18:09 Melatonin benefits for anti-cancer & antioxidant
22:37 Ketogenic diet for women
30:55 Ketogenic diet for children
32:48 Genetic aspect to keto diet?
38:32 Metformin for suppressing cancer
46:30 Ketogenic diet & Alzheimer’s
54:40 Exercise for mental health
55:53 Keto for exercise performance & bodybuilding
59:32 Endogenous metabolite & psychedelics
1:09:05 Connect with me (Aastha)
Episode Show Notes: https://livelongerworld.substack.com/p/dom2
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. If you like the podcast, please leave a review on Apple podcasts.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
All platforms / Episode Transcript & Timestamps: https://livelongerworld.substack.com/p/dom1
Dr. Dom D’Agostino may require no introduction especially in the world of ketosis! He is an Associate Professor with his research focusing on metabolic therapies, ketogenic diets, ketone supplements, and other metabolic based drugs. He is also a research scientist at the Institute of Human and Machine Cognition.
This is Part 1 of a 2 part conversation with Dom. He has so much knowledge to share and in this episode we dive into the history of ketogenic diets, keto for brain health and neuroprotective seizures, keto for longevity benefits, weight training, caloric restriction and more. Hope you enjoy the episode!
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/livelongerworld
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DOM D'AGOSTINO LINKS:
KetoNutrition: https://ketonutrition.org/
Website: https://linktr.ee/Domdagostino
Twitter: https://twitter.com/DominicDAgosti2
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
TIMESTAMPS:
0:00 Ketogenic diet is not optimal for everyone
0:56 Dom D’Agostino Intro
1:29 Plant-based ketogenic diet
3:20 Ketogenic diet & brain protection against seizures
16:40 Ketone Esters & Salts
19:29 Does the brain need glucose?
21:37 Intermittent Ketosis & Fasting Mimicking Diet
25:17 Cyclic Ketogenic diet for longevity
28:40 Devices for tracking ketosis
30:30 Ketogenic diet for longevity vs. Caloric restriction
37:50 Keto diet for cancer prevention
41:57 Keto diet, Insulin pathway, and glucose
46:50 Time restricted eating benefits
50:17 Dom vs. Layne Norton on Joe Rogan podcast
51:40 Muscle for longevity (especially for women)
56:10 Support Live Longer World
Episode Show Notes: https://livelongerworld.substack.com/p/dom1
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/sapple
Sam Apple is the author of Ravenous: Otto Warburg, The Nazis, and the Search for the Cancer-Diet Connection.
Otto Warburg was a Nobel-Prize winning German scientist during the era of Hitler and the Nazi’s and he was the first person to put the metabolic story of cancer on the map. The famous “Warburg Effect” that shows how cancer cells have an increase in glucose uptake even in the presence of oxygen, is named after him.
It was a fascinating conversation talking about how the story of cancer research has evolved - how cancer cells eat to the discovery of oncogenes to coming full circle and making the connection between the two, and what the debate still holds in the story. We also talk about how cancer cells take up a lot of glucose, feed on sugar, and the connection between obesity and cancer. I hope you enjoy the conversation!
Find the previous podcast episodes & subscribe to be notified: https://livelongerworld.substack.com/
Find me (Aastha) on Twitter: https://twitter.com/livelongerworld
SUPPORT LIVE LONGER WORLD:
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
SAM APPLE LINKS:
Ravenous book: https://amzn.to/3yT9qpd
Website: http://www.samapple.com/
Twitter: https://twitter.com/Sam_Apple1
CONNECT WITH AASTHA, LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
TIMESTAMPS:
0:00 Cancer as a disease of modern societies
1:27 Otto Warburg & the Cancer-Metabolic Connection
2:27 Warburg’s research on respiration
4:02 Why was cancer skyrocketing in Western societies?
9:17 Warburg Effect: Warburg’s research on cancer cells
15:00 Why do cancer cells take up so much glucose?
17:44 Cancer-Diet Connection
21:44 Cancer, Ketogenic diets & Fasting
23:43 Hibernation of the metabolic story of cancer
27:20 Hitler’s connection with cancer
30:07 Warburg’s arrogance
31:51 Why does cancer need glucose?
38:46 Warburg’s stigma: connecting with Nazi’s
40:51 Is insulin responsible for cancer?
48:00 Science is not immune from politics
50:24 Prostate cancer & obesity
52:13 Pendulum swing in cancer research
54:40 Mitochondria & Cancer Connection
57:07 Nazi’s fixation on cancer
Episode Show Notes: https://livelongerworld.substack.com/p/sapple
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for listening & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev
Dr. Vadim Gladyshev is a professor at Harvard Medical school and a Director of redox medicine at Brigham and Women’s hospital, where he runs his own lab. We had a brilliant discussion which started off by talking about his work on selenium. Selenium is found is Brazil nuts and we discussed its connection to aging and cancer prevention, and also some of the harmful effects it can have. Dr. Gladyshev calls it the good, the bad, the ugly nature of selenium.
Then, we discussed a fair bit on his theory of aging before and after development. Most people believe that the germline which is the reproductive cells do not age, but his lab’s work has shown how the germline does in fact age. On this point, his lab also has interesting results on how rapamycin during development extended lifespan in mice.
It’s important to understand the basic science and understand more on the aging process in order to crack it. Dr. Gladyshev shares his views on this too and his research is certainly a step towards cracking the aging code. I hope you enjoy the conversation!
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworldOne-Time support: https://www.paypal.com/paypalme/livelongerworld
Find me on Twitter: https://twitter.com/livelongerworld
VADIM GLADYSHEV LINKS:
Website: https://gladyshevlab.bwh.harvard.edu/2022
Rapamycin During Development extends Lifespan: https://www.biorxiv.org/content/10.1101/2022.02.18.481092v1
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Vadim Gladyshev Intro
1:28 Live Longer World
2:17 Selenium’s dual role in aging (the good, the bad, the ugly)
11:27 Antagonistic Pleiotropy
13:53 Selenium & Cancer
15:58 Selenium Dosage (don’t get too much!)
18:30 Reactive Oxygen Species, Antioxidants & Aging
22:30 Fundamental basis of Aging
24:09 Aging is damage
29:20 Single cell Epigenetic Clocks
34:22 Aging in the Womb
42:16 Parent’s lifestyle for aging in embryo
44:14 Rapamycin during development
49:06 Other compounds
51:53 Slowing Aging vs. Rejuvenation
56:08 New projects being worked on
57:17 Confidence level in extending lifespan within 30 years
59:17 Support Live Longer World
Episode Show Notes: https://livelongerworld.substack.com/p/vgladyshev
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for watching & if you enjoy the episode, let's spread the message on longevity.
You can support my work by sharing, liking, subscribing, leaving a review on Apple podcasts, donating on Patreon, or signing up as a premium member.
Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
Dr. Ethan Weiss is a cardiologist and his special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young. In today’s conversation we spoke about misconceptions people have about heart disease, genetic factors involved in heart disease, how to understand cholesterol and triglycerides in the context of heart disease, ketogenic diets for preventative cardiology and so much more.
If you want to understand how to think about your risk assessment for cardiovascular disease and how to prevent it, this conversation is for you.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/eweiss
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Transcripts: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
ETHAN WEISS LINKS:
Website: https://profiles.ucsf.edu/ethan.weiss
Twitter: https://twitter.com/ethanjweiss
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Welcome to Live Longer World
0:44 Misconceptions of heart disease / young people with heart disease
4:01 Predictors of heart disease
6:59 LDL vs HDL; Triglycerides
12:51 Small-dense LDL vs. Large fluffy LDL
16:09 Dietary Carbohydrates & heart disease risk
25:50 Inflammation & Cardiovascular risk
26:43 Lipoproteins, ApoB, Lp(a)
31:31 Statins, PCSK9 inhibitors
32:45 ApoB as gold standard risk marker
36:50 Triglycerides & Insulin resistance
40:00 Saturated Fat
42:42 Variation in Cholesterol measurement
46:03 Body composition as marker for heart disease risk
51:23 Ketogenic diets & heart health
56:43 Keyto breath sensor
1:01:46 Stress & heart disease
1:04:44 Growth hormone & heart disease
1:07:46 On the shortness of life
1:10:52 Support & Connect with
Live Longer World Episode Show Notes: https://livelongerworld.substack.com/p/eweiss
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
Thanks for listening & if you enjoy the episode, let's spread the message on longevity.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
Dr. Michael Levin is an American developmental and synthetic biologist at Tufts University where he heads his own lab. He also directs the Tufts Center for Regenerative and Developmental Biology.
His groundbreaking research focuses on bioelectrical signals that dictate the collective intelligence of cells and direct it to form tissues and organs. His work on bioelectric signals has important applications for how we understand cancer, regenerative medicine and even aging. In fact, he is collaborating with David Sinclair to see how his work can be applied to reverse aging.
Michael Levin’s work is fascinating and will surely leave you thinking. I hope you enjoy the conversation!
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/mlevin
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
MICHAEL LEVIN LINKS:
Website: https://ase.tufts.edu/biology/labs/levin/
Twitter: https://twitter.com/drmichaellevin
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/
Live Longer World Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:40 How do cells decide what to build?
10:05 DNA is insufficient for dictating collective intelligence of cells
19:00 Anatomical Complier (End game)
22:24 History of Cellular Collective Intelligence & Ala Turing
26:30 Regenerative Medicine & Morphoceuticals
38:05 Cells forming new anatomies
44:53 Cancer as a morphogenetic problem
55:16 David Sinclair, Bioelectrics to reverse aging
57:44 Synthetic Wombs & Artificial Life
59:41 Support Live Longer World!
Episode Show Notes: https://livelongerworld.substack.com/p/mlevin
Live Longer World Season 1 Recap: https://livelongerworld.substack.com/p/season1
If you enjoy my work and wish to support it, consider sharing it with a friend or two and leaving a review on Apple podcasts.
And if you are further inclined to show love and support, you can donate on Patreon: patreon.com/livelongerworld
Thanks for watching & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
Dr. Richard Miller runs one of the labs for the Interventions Testing Program or the ITP, which is largely considered the gold standard for testing longevity drugs. This was one of the best conversations I’ve had on longevity supplements that affect lifespan and those that might me subject to mere hype. Dr. Miller is rigorous in his approach and states the data clearly. He also has opinions on lifespan vs. healthspan that are unique from those of most others and worth paying attention to. I genuinely walked away having learned so much from this conversation and feeling more awakened, and I hope it is useful to you too in parsing the data out there on longevity supplements.
In today’s episode, you will learn:
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The 4 winning drugs that increase lifespan in mice as tested by the ITP: Rapamycin, Acarbose, 17-alpha estradiol, Canagliflozin
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3 other drugs that produce small lifespan benefits: NDGA, Glycine, Captopril
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Drug combinations: Rapamycin + Acarbose, Rapamycin + Metformin
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Drugs that show no lifespan increase in mice in the ITP: Resveratrol, Nicotinamide-Riboside (NR), Fisetin, Curcumin, MCT Oil, Green tea extract, Fish Oil + more
-
Richard’s thoughts on lifespan vs. healthspan
All platforms / Episode Show Notes / Timestamps: https://livelongerworld.substack.com/p/rmiller
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
RICHARD MILLER LINKS:
Website: http://www.richmillerlab.com/
Photography: https://richardmiller.zenfolio.com/
Interventions Testing Program: https://www.nia.nih.gov/research/dab/interventions-testing-program-itp
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:55 Richard Miller Intro
1:51 Richard Miller Wildlife photography
3:30 ITP - the gold standard for testing longevity drugs & winning drugs
10:51 Rapamycin, Rapamycin + Acarbose
18:48 Rapamycin + Acarbose Dosing Schedule
20:15 Combination of drugs, Rapamycin + Metformin
21:56 17-Alpha Estradiol
25:45 Canagaflozin
31:34 Does Richard take the 4 winning drugs?
32:46 3 Drugs that have small lifespan effects & promising
36:30 GPLD-1 & shared mechanisms in longevity drugs
44:04 Resveratrol in ITP
46:27 NR, NMN
52:34 Curcumin, Green Tea Extract, MCT Oil
54:54 Fisetin & Senolytics
56:12 Why most published research findings are false
1:00:03 Healthspan biomarkers at the ITP
1:02:38 Can you have healthspan without lifespan?
1:07:37 Fish Oil, Spermidine, Sulforophane
1:12:13 Unpublished data Richard is excited about
1:17:47 Flying Pigs & Aubrey De Grey
1:20:00 Exponential rise in aging research
Episode Show Notes: https://livelongerworld.substack.com/p/rmiller
Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast.
Aging is universal. Let's unite in this fight.
Yuri Deigin is the founder and CEO of YouthBio Therapeutics which is a company that is working on Epigenetic reprogramming or using the Yamanka factors to achieve partial reprogramming.
Epigenetic reprogramming has been in the news lately because of several companies being started in the space, with some notable ones being Altos Labs funded by Jeff Bezos and NewLimit founded by Brian Armstrong, CEO of Coinbase. If you’re not familiar with this trending, hyped (rightly so this time - it is pretty amazing!) research on Epigenetic reprogramming and Yamanaka factors to turn cells back to a younger state, we dive into it in today’s episode!
As a last point to Yuri’s introduction, because I’d be remiss if I didn’t mention it, you may have heard of his name recently because he was in fact one of the first people to talk about the COVID lab leak theory and wrote extensively on it. This speaks to his scientific mindset and desire to uncover the truth.
In today’s episode, you will learn:
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The Strong Epigenetic Theory of Aging, as coined by Yuri (He calls David Sinclair’s theory The Weak Epigenetic Theory of Aging)
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Epigenetic Reprogramming using Yamanaka factors to turn the cell into a younger state
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What is it and what are the open questions in the field
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What are the cancer risks associated with it
-
Why Yuri believes in Cryonics
-
Why Yuri got interested in uncovering the COVID-19 Lab Leak theory
-
Pharma in Russia
If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
YURI DEIGIN LINKS:
Twitter: https://twitter.com/ydeigin
LinkedIn: https://www.linkedin.com/in/yurideigin/
Medium: https://yurideigin.medium.com/
YouthBio Therapeutics: https://youthbiotx.com/
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS:
00:00 "We're not crazy"
0:37 100% life extension & translation to humans
4:28 Aging is potentially an engineering problem
12:45 Strong Epigenetic Theory of Aging
19:26 Epigenetic Reprogramming
29:00 Risk of Cancer with Epigenetic reprogramming
33:00 Rejuvenation without cancer risk?
38:30 Why Cryonics Makes Sense
48:00 COVID Lab Leak Theory
53:45 Pharma in Russia
58:40 Optimism in Longevity
1:00:50 Aging is Universal. Let's Unite in this Fight
Episode Show Notes: https://livelongerworld.substack.com/p/ydeigin
Thanks for listening & if you enjoy the episode, let's spread the message on longevity. You can leave a review on Apple podcasts, subscribe and share the podcast.
Aging is universal. Let's unite in this fight.
Stay in good health - Aastha.
Dr. Peter Adams, Professor at Sanford Burnham Prebys Medical Discovery Institute, is an expert in the biology of aging and cancer. The Peter Adams Lab is focused on the Epigenetics of Cancer & Aging and their goal is to contribute to development of epigenetic-based interventions that promote healthy aging and suppression of disease, including cancer. You will hear about some of these contributions in this conversation.
In today’s episode, you will learn: * Cellular Senescence and it’s dual role in protecting against cancer but also causing tissue aging * The role of senolytic drugs to protect against age-associated cellular senesence * The connection between the mitochondria and cellular senescence * The Developmental theory of aging (Aging begins in the womb!)
If you are a premium subscriber, you can also read the summarized notes of these learnings in the show notes.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/padams
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber
Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
PETER ADAMS LINKS:
Lab Website & Bio: http://www.padamslab.org/pages/members.html
Peter Adams Twitter: https://twitter.com/AdamsBioAging
Peter's Recent Publications: https://www.sbpdiscovery.org/our-scientists/peter-d-adams-phd
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon: https://www.patreon.com/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Premium Subscriber: https://www.livelongerworld.com/premium
TIMESTAMPS & EPISODE SHOW NOTES: https://livelongerworld.substack.com/p/padams
Thanks for listening & if you enjoy the episode, let's spread the message on longevity. Aging is universal. Let's unite in this fight. Stay in good health - Aastha.
My guest today is Andy Lee who is the Chief Operating Officer at Vincere Biosciences. Vincere is working to stop Parkinson’s disease by creating small molecules or drugs that target mitochondrial dysfunction. There is increasing evidence that a dysfunctional mitochondria can lead to the onset of Parkinson’s disease.
In today’s conversation, we discussed the science behind a dysfunctional mitochondria and mitophagy, the relationship between the mitochondria and Parkinson’s disease, and whether certain mitochondria boosting supplements like Urolithin A and Coq10 that delay the onset of Parkinson’s. We also discussed the biological simulation and computational biology platform used by Vincere - they use AI systems that can be used to screen drugs & targets and simulate cell environments. Finally, we spoke about the challenges with running a biotech company.
Andy comes from a background in technology and computer science background and he combined it with biology to create Vincere Biosciences.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/alee
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
ANDY LEE / VINCERE BIO LINKS:
Vincere Website: https://vincerebio.com/
Andy Lee Twitter: https://twitter.com/andy_d_lee
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Live Longer World Intro
0:34 Andy Lee & Vincere Bio Intro
1:55 Vincere & the connection between mitochondria & Parkinson's
7:39 Mitophagy & Parkinson’s disease
16:29 Role of USP30 in Mitochondria & Parkinson’s
22:26 Vincere small molecules testing
25:18 Other pathways affected during Parkinson's
30:53 Computation Biology Platform used by Vincere
36:50 Urolithin A & Coq10 to help with Parkinson’s
39:45 Biomarkers for Mitophagy
42:46 Too much mitophagy?
44:50 Challenges running a biotech company
48:19 Path forward for Vincere
49:36 Support, share and follow Live Longer World!
Want Summarized Notes on Key Points Discussed in the Podcast? Gain access by signing up as a premium subscriber. Your contribution supports my work and the advancement of longevity science!
Key points summarized in the show notes for premium subscribers include:
-
The connection between Mitochondrial quality control & Parkinson’s disease
-
Mitophagy and the science behind targeting the mitochondria
-
Overview of the Biological Simulation Platform used by Vincere Bio
-
Can compounds like Urolithin A & Coq10 that target the mitochondria delay Parkinson’s
-
Challenges with running a Biotech Co.
Learn more on Premium Subscriber Benefits: https://www.livelongerworld.com/premium
Ep. Show notes: https://livelongerworld.substack.com/p/alee
My guest today is Dr. Bjorn Schumacher whose work focuses on the central role of DNA damage in the aging process. We discussed DNA damage accumulation with age, how DNA repair mechanisms play a role, how DNA damage in the reproductive cells can tell us a lot about aging, human fertility and reproductive capacity. We also discussed the role of p53 in cancer suppression, a new biological age clock being developed in his lab and how we should protect our skin from aging and thereby control DNA damage.
A lot of us have heard about the link between DNA damage and aging and this conversation really dives into it.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bschumacher
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Sign up for Premium Subscriber Summarized Show Notes on Key Points: https://www.livelongerworld.com/premium
Support on Patreon: https://www.patreon.com/livelongerworld
One-Time support: https://www.paypal.com/paypalme/livelongerworld
DR. BJORN SCHUMACHER LINKS:
Lab Website: https://www.cecad.uni-koeln.de/research/principal-investigators/prof-dr-bjoern-schumacher
Twitter: https://twitter.com/schumacherbj
Author of the book: The Mysteries of Human Aging: Surprising Insights from a Science That's Still Young: https://amzn.to/3LyR3JU
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
0:00 Live Longer World Intro
0:30 Bjorn Schumacher Intro
1:22 DNA Damage as Central to the Aging process
3:37 DNA repair with age
8:39 Premature aging; 2 distinct forms of DNA damage
14:15 How does an aging human survive with DNA damage & tamp down cancer?
18:20 Stress to reproductive cells builds up immunity in the body
24:41 Female reproduction, Menopause & DNA repair
27:46 p53 and it’s role in DNA repair
35:13 BiT Clock: New Biological Age Clock
43:59 Skin Aging and DNA damage
48:06 Stress in the intestine / gut can alter the chromosome
53:00 Germ cells are immortal
For links to DR. Bjorn Schumacher research discussed: https://livelongerworld.substack.com/p/bschumacher
Want Summarized Notes on Key Points Discussed in the Podcast?
Gain access by signing up as a premium subscriber. Your contribution supports my work the advancement of longevity science!
Key points summarized in the show notes for premium subscribers include:
- The central role of DNA damage in the aging process
- What happens to our body’s DNA repair mechanism with age?
- DNA Damage in the germ cells (reproductive cells) promotes stress resistance in the body
- The role of p53 in suppressing cancer and in the DNA repair process
Learn more: https://www.livelongerworld.com/premium
Thanks for listeni
My guest today is Dr. David Gems who runs the C. Elegans Aging lab at the University College London. We had a fascinating discussion talking about emerging paradigms in the theories of aging. We discussed the hyperfunction theory or the programmatic theory of aging which gives a better integrated understanding of the different theories of aging that have been presented such as damage accumulation, evolutionary, antagonistic pleiotropy. It has been assumed that molecular damage is always the cause of aging, but the programmatic theory of aging shows that that might not be the case. We also discussed his critique of the hallmarks of aging and how there should be a better paradigm for the aging field. Lastly, we also discussed how research from his lab on C. Elegans might explain some of the conflict around whether sirtuins affect lifespan and how C. Elegans also show versions of this programmatic theory of aging, which can give us a better understanding of how to study aging.
Note: There is a point in the conversation (40:41) where David pulls up some slides to better explain the Multifactorial Model of Aging. So if you are listening to the audio version, you might want to refer to YouTube or the show notes.
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/dgems
Support on Patreon: https://www.patreon.com/livelongerworld
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
DR. DAVID GEMS LINKS:
Lab Website: https://www.ucl.ac.uk/~ucbtdag/DGHistory.html
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
00:00 Live Longer World
00:25 David Gems Intro
1:47 History of the theories of aging
12:23 Hyperfunction / Programmatic Theory of Aging
24:57 Programmatic Theory of Aging in C. Elegans
36:59 Hyperfunction theory of Aging in Humans
40:41 Multifactorial Model of Aging 50:32 Mutation in C. Elegans affecting Sirtuin research?
59:57 Sirtuin research in humans & conflicting sirtuin research
1:04:44 Metformin affects the gut microbiome
1:07:41 Critique of the Hallmarks of Aging
1:16:12 Disruption in Early Life could lead to Aging related diseases
1:24:23 Support, share, and follow Live Longer World
To find links to David Gems research discussed, please refer to the show notes: https://livelongerworld.substack.com/p/dgems
Thanks for listening & if you enjoy the episode, please leave a review on Apple podcasts, support on Patreon, subscribe & share!
Stay in good health - Aastha.
My guest today is Dr. Bruce Ames who has received several awards and accolades for developing the Ames test which is used to detect carcinogens in commercial products. He showed how there were carcinogens in products such as hair dyes and children’s pajamas!
Later, Dr. Bruce Ames turned to studying micronutrients and how deficiency of important vitamins and minerals leads to accelerated aging. He came up with the Micronutrient triage theory, which says that when nutrient intake is insufficient, the body has a rationing mechanism and favors proteins needed for immediate survival at the expense of protection against future damage.
Dr. Bruce Ames is 93 years old and says that he is still exercising and eating healthy greens cooked by his lovely Italian wife! However, he says his cognitive capacity has slowed down (this is why we need rejuvenation therapies, even for the brain: listen to my episode with Dr. Jean Hebert who talks about Brain Aging and his strategy to reverse aging through replacement of the body parts: https://youtu.be/oerGUepWsH8).
I am grateful that I had a chance to converse with him on Vitamin D, longevity micronutrients, how micronutrient deficiency can lead to accelerated aging, his take on the science behind reversing aging, and his advice to younger people.
This is a shorter episode and I hope you learn more about the importance of micronutrients!
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/bames
RELATED WRITING:
My newsletter post explaining the Micronutrient Triage theory: https://livelongerworld.substack.com/p/bruceames
My post on Longevity Foods (Nutrition Doesn't have to be so complicated): https://livelongerworld.substack.com/p/longevityfoods
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Find me on Twitter: https://twitter.com/livelongerworld
Support on Patreon: https://www.patreon.com/livelongerworld
DR. BRUCE AMES LINKS:
Website: http://www.bruceames.org/
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
TIMESTAMPS:
00:00 Live Longer World
00:36 Bruce Ames Intro
1:50 Micronutrient triage theory
5:40 Micronutrient deficiencies & age acceleration
9:10 Vitamin D for healthy aging
12:26 CHORI Bar
14:46 Measuring micronutrients (blood finger-prick)
16:55 Bruce Ames diet
18:19 Asthma caused by obesity / bad diet improved by CHORI bar
21:21 Dr. Ames lifestyle over the years
22:47 Importance of zinc
24:15 Nutrition is complicated
24:44 Dr. Ames last words & advice for young scientists
Thanks for listening & if you enjoy the episode, please like, leave a review on Apple podcasts, subscribe & share! Stay in good health - Aastha.
My guest today is Dr. Brian Kennedy who is the Director for the Center of Healthy Aging at the National University of Singapore. He is also the former President and CEO of the Buck Institute of Research on Aging. Dr. Kennedy is well-known in the field of longevity & beyond and has been involved in critical aging research. Dr. Kennedy's lab is working on different small molecules and natural products that could boost longevity.
In today's discussion, we spoke about the network concept of the hallmarks of aging, the longevity effects of natural products like Alpha-Ketoglutarate (AKG), Spermidine and Urolithin A, and why combining some of these supplements might not be prudent. We also spoke about comparing the different biomarkers of aging, what we can learn from the longevity of bats, and why basic science is important.
All platforms / Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/bkennedy
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Support on Patreon: https://www.patreon.com/livelongerworld
DR. BRIAN KENNEDY LINKS:
Lab Website: https://medicine.nus.edu.sg/bch/faculty/brian-kennedy/
Twitter: https://twitter.com/BKennedy_aging
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
Twitter: https://twitter.com/livelongerworld
Newsletter: https://livelongerworld.substack.com/
Instagram: https://www.instagram.com/longevityfuture/
Patreon page: https://www.patreon.com/livelongerworld
Podcast All Platforms: https://anchor.fm/livelongerworld
YouTube: https://www.youtube.com/c/LiveLongerWorld
Apple Podcasts: https://apple.co/3eZAoAp
Spotify: https://spoti.fi/3eZB6O5
Google Podcasts: https://bit.ly/3HN0keG
Premium Subscriber Benefits: https://www.livelongerworld.com/premium
DR. BRIAN KENNEDY RESEARCH DISCUSSED:
2020 Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice: https://pubmed.ncbi.nlm.nih.gov/32877690/
2020 Aging Biomarkers: From Functional Tests to Multi-Omics Approaches: https://pubmed.ncbi.nlm.nih.gov/32084299/
2021 The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition: https://pubmed.ncbi.nlm.nih.gov/34060628/
2021 Association between housing type and accelerated biological aging in different sexes: moderating effects of health behaviors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436907/
2020 The World Goes Bats: Living & Tolerating Viruses: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341951/
2021 Yeast as a model organism for aging research: https://www.sciencedirect.com/science/article/pii/B9780128159620000081
Thanks for watching & if you enjoy the episode, please like, comment, subscribe & share! Stay in good health - Aastha.
My guest today is Dr. Collin Ewald who is a professor at the Health Sciences department at ETH Zurich. His lab focuses on understanding the extracellular matrix (ECM) and how it changes with age. Collin explains the role of the ECM in tissue repair, muscle strength, and overall longevity. In fact, Collin’s lab is also working on establishing the ECM as a biomarker for health and disease risk. So, studying the ECM can indeed tell us a lot about the aging process and ways to intervene.
Think of the ECM as the environment that surrounds the cell or the proteins secreted from the cell. It holds our organs and tissues in place. You’ve probably heard of collagen protein - it is largely found in the ECM.
Why is the ECM relevant for longevity research? Turns out, the ECM changes with age. In fact, each cell has a unique ECM and cancer cells can be detected by their ECM composition type! There is also a connection between the ECM and the muscle, and damage to collagen with age results in weakening of our muscles.
We discuss changes in collagen with age, how sugar impacts collagen, cancer cells & ECM, the overexpression of certain collagens with age, changes in collagen causing muscle impairment with age, and longevity interventions his lab is studying to repair the impairment damage.
(This podcast can be a little technical, especially in the beginning, so I’d recommend referring to the show notes for better understanding. The video version of the podcast also contains some explanations on the video slide itself.)
All platforms / Episode Show Notes: https://livelongerworld.substack.com/p/cewald
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
Support on Patreon: https://www.patreon.com/livelongerworld
DR. COLLIN EWALD LINKS:
Lab Website: https://www.ewaldlab.com/
Twitter: https://twitter.com/CollinEwald
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TIMESTAMPS:
Episode Page: https://livelongerworld.substack.com/p/cewald
YouTube: https://youtu.be/r1Y5wGSqKWA
DR. COLLIN EWALD RESEARCH:
The Matrisome during Aging and Longevity: https://www.karger.com/Article/FullText/504295
Collagen overexpression increasing lifespan: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/
Youthful and age‐related matreotypes predict drugs promoting longevity: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8441316/
Doubling life near death: https://elifesciences.org/digests/71335/doubling-life-near-death
Thanks for watching & if you enjoy the episode, please like, comment, leave a review, subscribe & share! Stay in good health - Aastha.
My guests in today's episode are Dr. Irina and Michael Conboy of the Department of Bioengineering at the University of California Berkeley.
Their groundbreaking research focuses on tissue rejuvenation via plasma dilution and heterochronic parabiosis, where the Conboys took a young mouse and an older mouse and sutured them together, such that the animals shared blood and environment. The old mice became rejuvenated & younger. They’ve also pioneered a process called the Neutral Blood Exchange or Therapeutic Blood Exchange, through which dilution of old blood plasma can lead to true rejuvenation in the brain & other tissues of mice to a younger state!!
Further, we touch upon Irina's work showing how decreased Oxytocin levels with age contributes to poor muscle function. Their research is incredibly exciting and we discuss all about it in today’s episode.
Episode Show Notes: https://livelongerworld.substack.com/p/rejuvenation-via-plasma-dilution
Sign up for Premium Subscriber Extensive Show Notes & Transcripts: https://www.livelongerworld.com/premium
Find the previous podcast episodes & subscribe to be notified: https://www.livelongerworld.com/podcast
DR. CONBOY LINKS: Berkeley Lab: https://conboylab.berkeley.edu/
2021 Paper Plasma Dilution Improves Cognition and attenuates neuroinflammation in old mice: https://pubmed.ncbi.nlm.nih.gov/33191466/
2020 Paper Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288913/
2014 Paper Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration: https://www.nature.com/articles/ncomms5082
LIVE LONGER WORLD LINKS:
Website: https://www.livelongerworld.com/
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Google Podcasts: https://bit.ly/3HN0keG
TIMESTAMPS:
00:00 Live Longer World Intro
00:35 Irina & Michael Conboy Intro
1:08 Aging is slowdown in our repair machinery
2:55 Naked Mole Rats not extreme model for longevity
5:37 Heterochronic Parabiosis
16:00 Young Blood to Old Blood Exchange
19:19 Rejuvenation via Neutral Blood Exchange (NBE)
22:56 Old Blood Degenerates Young Mice
25:29 Rejuvenation Effects on Brain, Liver, Muscle through NBE
27:16 How long do effects of NBE last?
30:15 How is NBE working mechanistically? 2 waves of rejuvenation
33:38 Inhibiting TGF-beta & Increasing Oxytocin is rejuvenative
38:12 NBE vs. Senolytics
40:53 Unanswered Questions on NBE
43:13 Oxytocin & Muscle Functioning; Notch Signaling
48:12 Chickens & Ravens as Pets!
Thanks for listening & if you enjoy the episode, please like, subscribe & share! Stay in good health - Aastha.
Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.
Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today’s episode and also in his book Age Later.
He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.
In today's episode, we discuss centenarian longevity genes, what makes centenarians live so long and the role of growth hormones in longevity. We also dive into metformin's healthspan benefits for longevity, metformin & COVID, if metformin blunts muscle mass and causes hypoglycemia, and metformin dosage.
Episode Show Notes + Timestamps: https://livelongerworld.substack.com/p/snbarzilai
FOLLOW NIR BARZILAI:
Profile: https://einsteinmed.edu/faculty/484/nir-barzilai/
Twitter: https://twitter.com/NirBarzilaiMD
Book: https://us.macmillan.com/books/9781250230867
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The final 2021 episode of the Live Longer World podcast is a rather special one. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode. Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogramming, Atherosclerosis, Brain Aging and more. And if a particular topic or clip captures your attention, you can of course go and watch the entire podcast episode. Hope you enjoy it and wishing everyone a happy & healthy holiday season!
Episode Show Notes: https://livelongerworld.substack.com/p/2021
Find the previous podcast episodes: https://www.livelongerworld.com/podcast
2021 Live Longer World podcast episodes:
01: Reason, founder & CEO of Repair Biotechnologies
02: Dr. Jean Hebert on Tissue Replacement in the Brain
03: Carolina Oliveira, the founder & CEO of OneSkin
04: Dave Gobel, founder & CEO of Methuselah Foundation
05: Dr. Matt Kaeberlein on Aging Interventions, Rapamycin, mTOR
06: Dr. Morgan Levine on Epigenetic Clocks, SystemsAge Clock
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Dr. Morgan Levine is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine. Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease.
I can’t even begin to tell you how much I learned in today’s conversation!
We extensively discussed Morgan’s work on developing a new Epigenetic clock called the SystemsAge clock, which is very cool and can test the biological age of different organs & systems in your body.
We also spoke of different features of these clocks, interventions tested, what we know so far on reversing your biological age, some of the limitations of the clocks, why she is so excited about epigenetic reprogramming, and some of her work around Alzheimer’s disease.
Most people are interested in knowing their biological age and epigenetic clocks are a way to test it. So I’m sure you will find this conversation on epigenetic clocks fascinating and walk away understanding them much better!
I hope you enjoy my conversation with Dr. Morgan Levine.
Show notes + Timestamps: https://livelongerworld.substack.com/p/mlevine
FOLLOW DR. MORGAN LEVINE:
Morgan's Lab: https://www.morganlevinelab.com/
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Dr. Matt Kaeberlein is a Professor of Pathology, Adjunct Professor of Genome Sciences, and Adjunct Professor of Oral Health Sciences at the University of Washington. His research interests are focused on basic mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.
Matt has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive conversation where we spoke about how Matt thinks of aging from a functional perspective, caloric restriction and aging, whether NAD+ precursors are effective in slowing aging, the role of sirtuins.
We discuss quite a bit on rapamycin and how it’s shown to be effective in improving the health of mice. Matt is very excited about the potential benefits of Rapamycin in reversing aging and he got me excited too. Matt is also working on the Dog Aging project and in trying to understand aging in dogs.
Finally, we end the conversation by talking a bit on what good scientific practices should look like. Matt approaches his work with an unbiased lens and that’s very respectable. Matt has a brilliant mind! I had such a blast talking to Matt and I hope you enjoy the conversation as much as I did!
Timestamps in the YouTube version of this podcast:
ttps://www.youtube.com/channel/UCcoEB1MXhkI_CFwsHRtPXUg
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Store: https://www.longevitystore.co/
FOLLOW MATT KAEBERLIN:
Website: https://kaeberlein.org/
Twitter: https://twitter.com/mkaeberlein
Dog Aging Project: https://dogagingproject.org/
My guest today is David Gobel who is the co-founder & CEO of the Methuselah foundation. Methuselah foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. I’m definitely rooting for that!
Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah including Oisin Biotechnologies, the concept of longevity escape velocity, his work with the super centenarian research foundation, how one can get involved in funding longevity companies and more.
I hope you enjoy the episode!
TIMESTAMPS:
0:00 Live Longer World Intro
1:30 David Gobel & Methuselah Foundation Intro
2:00 Dave's work at the TSA; Innovation at TSA
10:39 Methuselah Fund, How Dave got interested in Longevity & met Aubrey De Grey
19:14 The current healthcare system does not focus on preventative medicine; Aging is the biggest risk factor for all diseases
20:40 Methuselah Foundation mission - Making 90 the new 50 by 2030
26:56 Companies funded by Methuselah - Turnbio, Epigenetic reprogramming, Organovo 3D Tissue Printing
30: 18 Leucadia Therapeutics & working to erase Alzheimer's disease
37:20 Donating to Longevity
38:24 Investing in Longevity - how to get started
40:20 Vascular Tissue Challenge with NASA
43:05 Longevity Escape Velocity
47:28 Challenges in the Longevity Field (Money comes to winning solutions & ideas!)
51:55 Do we use money or does money use us?
57:00 Ending remarks
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FOLLOW METHUSELAH FOUNDATION:
Website: https://www.mfoundation.org/
Twitter: https://twitter.com/mfoundation
Carolina Reis Oliveira is the founder & CEO of OneSkin Technologies.
OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging.
Carolina holds her Ph.D. in Immunology at the Federal University of Minas Gerais in collaboration with the Rutgers University and is an alumnus of IndieBio, the world's leading biotechnology accelerator. In 2016, Carolina relocated to Silicon Valley from Latin America to co-found OneSkin, and to lead the development of the company’s disruptive rejuvenation technologies.
Carolina is full of energy and I really enjoyed talking to a scientist entrepreneur!
0:00 Live Longer World Intro
1:06: Carolina & OneSkin Intro
2:25 Jokes, Pleasing Indian Mom 4:00 Skin Aging; Cellular Senescence
8:05 Skin Overlooked in Longevity Research; Concentration of Senescent Cells in Skin
11:30 OneSkin Product; OS-1 Peptide
17:35 Does the product work across ethnicities & skin types?
20:55 Results from product; elimination of senescent cells
23:42 Senomorphics (slow down progression of senescent cells)
25:50: Results from studies in C. Elegans
30:31 OneSkin vs. Fistein vs. Retinol
35:21 Recommendation if using Retinol
37:21 Senolytic Drugs vs. OneSkin
40:19 Skin aging from Sun Damage
42:17 Which age to start using OneSkin?
44:47 Human Studies for OS-1
49:08 FDA Approval for drugs
51:00 Future products
53:47 Excitement about Longevity Industry
56:47 Connect with OneSkin
58:17 Connect with Live Longer World
FOLLOW LIVE LONGER WORLD:
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Jean M. Hébert, PhD, is a Professor of Neuroscience and Genetics at the Albert Einstein College of Medicine in New York.
Dr. Hebert was fascinated from a young age by how a single cell forms the whole human body following an innate genetic program and he got excited by how knowledge of this process might be used to improve our biological fates and defeat aging.
He is a molecular geneticist by training and obtained his Ph.D. from the University of California, San Francisco, before specializing in the study of how neural stem cells form the brain at Stanford University.
His lab is now developing ways to use cell and tissue replacements to repair and rejuvenate the brain. More specifically, the Hébert Lab is engineering tissue that increasingly resembles normal neocortex, the part of our brain that performs our highest cognitive functions, and testing the ability of this tissue to integrate with the host brain.
Jean is the author ofReplacing Aging.
We had an extremely interesting conversation ranging from why Dr. Hebert thinks the other methods to fight aging may not work if the goal is to beat aging, we discuss 3D organs and tissue cell replacement and we also discuss the neocortex and what it takes to replace one and lastly we talk about how plasticity in the brain works.
Even if you are not associated with the field of longevity, you’ll find this conversation interesting and refreshing.
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FOLLOW DR. JEAN HEBERT:
Twitter: https://twitter.com/Replacing_Aging
Website: https://hebertlab.einsteinmedneuroscience.org/
Reason is the founder and CEO of Repair Biotechnologies. Repair Biotechnologies is a biotech company focused on developing therapies that treat medical conditions arising due to accumulation of excessive cholesterol. They have developed a unique Cholesterol Degrading Platform to reverse the damage that leads to heart disease and atherosclerosis. More than 5 million people die every year due to atherosclerosis and Repair Biotechnologies is trying to solve this problem.
Reason is perhaps most well known for his popular blog Fight Aging! where he distills the latest research in aging science. For anyone looking to stay informed on aging & longevity research, I highly recommend you checking it out - it’s one of the best resources out there.
In today’s conversation, we discuss how to think of aging simply, the differences between slowing and reversing aging, NAD+ boosters and their effectiveness, reversing aging using senolytics, how his company is working on a gene therapy to reverse artherosclerosis and cardiovascular disease, problems with Alzheimer's research, working towards aging rejuvenation therapies, how one can get involved in the aging space, and much more.
Note: We discuss a fair bit on cellular senescence and senolytic therapies. For those unfamiliar with the concept, cellular senescence is a process in which cells lose their ability to divide but refuse to die. When these senescent cells don’t get cleared away, they release harmful substances and damage the cells around them too.
It is well known that senescent cells accumulate with age, contributing to inflammation and aging itself. Senolytics is a class of drugs that can selectively clear away these senescent cells and they have shown promise in delaying and preventing age-related diseases.
FOLLOW LIVE LONGER WORLD:
Website: https://www.livelongerworld.com/
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FOLLOW REASON AND REPAIR BIOTECHNOLOGIES:
Fight Aging! Blog: https://www.fightaging.org/
Company Website: https://www.repairbiotechnologies.com/
"Can I really live to be 200? Can I feel like I’m 20 when I’m 70? Can aging be reversed? Hold up, what even is aging? Now I’m curious to know about aging and longevity science!"
Well then, you're at the right spot! Hello and welcome to Live Longer World!
The science of aging is moving rapidly and making progress at defeating age-related diseases and aging itself. We take you right where the action is happening! Through conversations with scientists, entrepreneurs, investors and other advocates revolutionizing the field of longevity science, we tell you how you can be disease-free, reverse aging, and maximize longevity in the future.
To stay informed on what the future of aging and longevity looks like, make sure to subscribe to Live Longer World at Apple podcasts, Spotify, YouTube or wherever you get your podcasts. We look forward to transforming how we age in the future and bring you along on this wonderful journey.