RxUnedited: Recent Episodes
RxUnedited
Sharing what we learned about euglycemic diabetic ketoacidosis topic through a brief case discussion. Thanks for listening!
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
A special collab with some friends on wellbeing. Hear the perspectives from other professionals outside of pharmacy. Thank you Thinh, Vince and Alan for helping to make this episode possible!
Meet our two wonderful guests Stephanie and Anh as they share and reflect on their search for a pharmacy residency. As always, thank you for listening!
We are back this time with an excite new article on early-rhythm control therapy in atrial fibrillation, the EAST-AFNET4 trial. Reference to the article is listed below. Follow us on Instagram today: https://www.instagram.com/rx.unedited/
Kirchhof P, Camm AJ, Goette A, et al. Early rhythm-control therapy in patients with atrial fibrillation. N Engl J Med 2020;383:1305-16.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
This is one of my favorite episodes so far. Carolyn and Ann joined us to share their experience and perspectives on mental wellbeing and resilience. There has been a lot of effort in raising awareness for mental health recently, so instead of going over the same thing, let's hear what others have to say.
In this episode, we discuss the basics in identifying and treating acute cystitis and pyelonephritis.
References: 1. Kaye KS, Rice LB, Dane AL, et al. Fosfomycin for injection (ZTI-01) versus piperacillin-tazobactam for the treatment of complicated urinary tract infection including acute pyelonephritis: ZEUS, a phase 2/3 randomized trial. CID. 2019; 69: 2045-2056. 2. Cortes-Penfield NW, Trautner BW, Jump RLP. Urinary Tract Infection and Asymptomatic Bacteriuria in Older Adults. Infect Dis Clin North Am. 2017;31(4):673-688. doi:10.1016/j.idc.2017.07.002 3. Nicole LE, Gupta K, Bradley SF, et al. Clinical practice guidelines for the management of asymptomatic bacteriuria: 2019 update by the Infectious Diseases Society of America. CID 2019;68(10):e83-75. 4. Gupta K, Hooton TM, Naber KG, et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. CID 2011;52(5):e103-120.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
We review and discuss the clinical trials for both the Pfizer-BioNTech and Moderna COVID-19 vaccines.
Follow us on Instagram today: https://www.instagram.com/rx.unedited/
References: 1. Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [published online ahead of print, 2020 Dec 30]. N Engl J Med. 2020;NEJMoa2035389. doi:10.1056/NEJMoa2035389 2. Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med. 2020;383(27):2603-2615. doi:10.1056/NEJMoa2034577
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
We present to you a bite-sized version of atrial fibrillation in this episode. Because we're pharmacists, we mainly focus on the medications used for atrial fibrillation :)
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References: 1. January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: executive summary. J Am Coll Cardiol. 2014 Dec, 64 (21) 2246-2280. 2. January CT, Wann LS, Calkins H, et al. 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration With the Society of Thoracic Surgeons. Circulation. 2019;140:e125-e151. 3. Khan SU, Osman M, Khan MU, et al. Dual versus triple therapy for atrial fibrillation after percutaneous coronary intervention. Ann Intern Med. Doi:10.7326/M19-3763.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
In this episode, we discussed the principles of drug interactions and review some relevant drug interactions that we see commonly in practice.
Follow us on Instagram today: https://www.instagram.com/rx.unedited/
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
Welcome to our 10th episode! We answer your questions about cefepime-induced encephalopathy, serotonin syndrome, and others about pharmacy. Thank you all for your continued interest!
Follow us on Instagram today: https://www.instagram.com/rx.unedited/
Some references used for this episode: Boyer EW, Shannon M. The Serotonin Syndrome. N Engl J Med 2005;352:1112-20. Karkow DC, Kauer JF, Ernst EJ. Incidence of serotonin syndrome with combined use of linezolid and serotonin reuptake inhibitors compared with linezolid monotherapy. J Clin Psychopharmacol 2017 Oct;37(5):518-523. Hassamal S, Miotto K, Dale W, et al. Tramadol: Understanding the risk of serotonin syndrome and seizures. Am J Med 2018;131:1382.e1-1382.e6. Payne LE, Gagnon DJ, Riker RR, et al. Cefepime-induced neurotoxicity: a systematic review. Critical Care 2017;21:276. Bhattacharyya S, Darby RR, Raibagkar P, et al. Antibiotic-associated encephalopathy. Neurology. 2016;86(10):963-971. doi:10.1212/WNL.0000000000002455.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
In this episode, we discuss the updates from the recent Infectious Diseases Society of America (IDSA) guidelines for community acquired pneumonia (CAP). Thank you for listening!
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
We welcome out friend Ethan on the show to discuss his research project. In addition, we share our opinions on common medication allergies encountered and our process for approaching them.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
Back from our small break and we're changing up the topics! In this episode, we review the current guidelines from the American Diabetes Association (ADA) for management of DKA.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
*Kitabchi AE, Umpierrez GE, Miles JM, et al. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009;32(7). 1335-1343.
This time, we review the current options for emergent reversal of DOACs (direct oral anticoagulants) for a major, life threatening bleed. Plus, we discuss some recent literature published regarding use of PCCs (pro-thrombin complex concentrate) and andexanet alfa. In summary, emergent reversal of DOACs in major bleeding is clear as mud.
Connolly SJ, Crowther M, Eikelboom JW, et al. Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors. N Engl J Med. 2019;380:1326-35. Peled H, Dau NQ, Lau H. Key points to consider when evaluating Andexxa for formulary addition. Neurocrit Care. 2019. https://doi.org/10.1007/s12028-019-00866-6. Piran S, Khatib R, Schulman S, et al. Management of direct factor Xa inhibitor-related major bleeding with prothrombin complex concentrate: a meta-analysis. Blood Advances. 2019;3(2):158-167. Kaide CG, Gulseth MP. Current strategies for the management of bleeding associated with direct oral anticoagulants and a review of investigational reversal agents. J Emerg Med. 2019. https://doi.org/10.1016/j.jemermed.2019.10.011. Schulman S, Kearon C and. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non‐surgical patients. Journal of Thrombosis and Haemostasis, 3: 692-694. doi:10.1111/j.1538-7836.2005.01204.x Khorsand N, Majeed A, Sarode R, et al. Assessment of effectiveness of major bleeding management: proposed definitions for effective hemostasis: communication from the SSC of the ISTH. J Thromb Haemost 2016; 14: 211– 4.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
We check out some interesting studies and reviews on anticoagulation that were published recently. Citations are below for those interested in checking them out personally. P.S. please excuse my hiccup with warfarin :( you will see. Thanks for listening!
Coons J, Albert L, Bejjani A, et al. 2020. Effectiveness and Safety of Direct Oral Anticoagulants versus Warfarin in Obese Patients with Acute Venous Thromboembolism. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 40(3), pp.204-210. Khan SU, Osman M, Khan MU, et al. Dual versus triple therapy for atrial fibrillation after percutaneous coronary intervention. Ann Intern Med. Doi:10.7326/M19-3763. Kido K, Lee J, Hellwig T, et al. 2019. Use of Direct Oral Anticoagulants in Morbidly Obese Patients. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 40(1), pp.72-83. Lutsey PL, Norby FL, Ensrud KE, et al. Association of anticoagulant therapy with risk of fracture among patients with atrial fibrillation. JAMA Intern Med. 2020; 180:245-53. *Ordi-Ros J, Saez-Comet L, Perez-Conesa M, et al. Rivaroxaban versus vitamin K antagonist in antiphospholipid syndrome. Ann Intern Med. 2019;171:685-694.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
A quick refresher on medications that can be used in hypertensive crises along with their benefits and risks.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
We welcome our first guests Thinh and Khanhly on the show! Both are practicing RNs in the critical care setting. They came to share with us their knowledge about different types of IV access and use of IV pumps in the hospital setting.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.
We skipped the basics of HFrEF to bring you updates from 2017 heart failure guidelines, PIONEER-HF and DAPA-HF.
This podcast is intended for healthcare professionals and students only. Materials presented are for informational purposes, not to be used as medical advice or treatment.