Physiology and Behavior: Recent Episodes
Dan Quintana
Dan Quintana is a scientist trying to better understand how our physiology influences behaviour. On this show you'll find a mix of episodes on research that's catching Dan's eye in biological psychology, interviews with other scientists, and Dan sharing his daily research process.
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In this episode I chat with Izelle Labuschagne, who is the founder of the Complete Thesis support group, about reproducible science [3:42], social media for academics [21:20], and responding to reviewer comments [39:25].
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This is the audio version of a paper I recently co-authored in Trends in Cognitive Sciences, titled "How podcasts can benefit scientific communities". I'm reading the preprint version of the article, which is very similar to the published version.
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This was a talk I recently did on social media for academics. I cover both why and how academics can use social media to boost their academic careers. The slides are available here.
Enjoy!
This episode is the audio version of our paper, titled "An Allostatic Theory of Oxytocin", that was recently published in Trends in Cognitive Sciences.
Here is the abstract:
Oxytocin has garnered considerable interest for its role in social behavior, as well as for the potential of intranasal administration to treat social difficulties. How- ever, current theoretical models for the role of oxytocin in social behavior pay little consideration to its evolutionary and developmental history. This article aims to broaden our understanding of the role of oxytocin in social behavior by adopting an ethological approach through the lens of Nikolaas Tinbergen’s 'four questions' – how does oxytocin work; how does the role of oxytocin change during development; how does oxytocin enhance survival; and how did the oxytocin system evolve? We argue that oxytocin is most accurately described as an allostatic hormone that modulates both social and non-social behavior by maintaining stability through changing environments.
This is a virtual talk I recently gave to PhD students at Linköping University on how to better adjust to working from home
The video and the slides from this talk can be found here.
The main hesitation I hear from researchers when it comes to social media is that they've got nothing to share. In this short clip, I show you can you can share ten different bits of information, across different platforms, using just one idea.
Here's the video version of this clip.
This podcast episode is about starting your own podcast!
Here are some of the links, services, and products that I mention:
- The mega microphone review from Marco Arment
- Audio-Technica ATR2100-USB Cardioid Dynamic USB/XLR Microphone
- Fireside podcast hosting
- Acast podcast hosting
- Anchor podcast hosting
- Auphonic audio editing
- Izotope RX audio editing
- OBS screen recording software
- eCamm screen recording software
- Share video clips previews using Headliner
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This is a talk a recently gave at the university of Copenhagen in which I discuss ways we can improve the precision of oxytocin research.
Download the slides here.
Here is the talk abstract:
The neuropeptide oxytocin has garnered considerable interest for its role in social behavior and its potential for the treatment of psychiatric illnesses characterised by social dysfunction. However, initial excitement has turned to disappointment with some studies failing to replicate earlier results, which has been attributed to issues surrounding research methods, mechanistic understanding, and theory development. In this talk, I will discuss efforts to improve research design to enhance reproducibility, including precise sample size estimation, synthetic datasets, and ways to test evidence for null models. I will also describe two lines of research aiming to better understand oxytocin signalling mechanisms: i) Research identifying whole brain voxel-by-voxel gene expression patterns of the oxytocin receptor (OXTR) gene and its association with mental states via a large-scale fMRI meta-analysis of 14,371 studies and ii) data from two clinical trials demonstrating that compared to placebo, 8IU intranasal oxytocin (but not 24IU intranasal oxytocin or 1IU intravenous oxytocin) modulates social cognition, pupil diameter, and neural activity. Altogether, these studies provide the first steps towards identifying targets for oxytocin receptor engagement in the human brain and suggest that a lower 8IU intranasal dose might be more efficacious than the conventional 24IU dose. I will close by presenting my new theory of oxytocin’s role in human behaviour, which proposes that oxytocin modulates both social and non-social behaviour to maintain stability in changing environments.
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In this episode, Dan shares some audio from a recent interview that he did on his recent paper examining clinical trial reporting in anorexia nervosa studies.
Dan on Twitter and Instagram
In this talk, I share how open access benefits society, your research, and science.
Find the slides here.
A 2018 study that provides mixed support for a causal link between single dose intranasal oxytocin and spiritual experiences
Dan on Twitter and Instagram
A new study provides oxytocin-like receptor distribution maps for the brains of three birds species
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A new study suggests that oxytocin blocks enhanced motivation for alcohol in alcohol dependent rats
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A new study suggests that oxytocin does not influence social decision making in Capuchin monkeys
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A new study suggests that systemic oxytocin administration alters mesolimbic dopamine release in mice
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A new study suggests that intranasal oxytocin decreases task-related aggressive responses in young males
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A new study suggests that oxytocin increases male-directed threats and vocalizations in female macaques
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A new study investigates the impact of oxytocin on pupil dilation in response to novel social and non-social stimuli
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A new study investigates the role of oxytocin in dealing with the idea of one’s mortality
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A new study demonstrates the role of oxytocin in the modulation of paternal behavior in mandarin voles
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A new study demonstrates that oxytocin administration modulates helping behaviour in rats depending on social context
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A new study in the journal Nature demonstrates oxytocin-dependent reopening of a social reward learning critical period with MDMA
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A new study suggests that oxytocin attenuates stress-induced reinstatement of alcohol seeking behavior in mice
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A new study investigates associations between oxytocin and cortisol activity in response to psychological stress and sexual arousal
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A new study investigates the neurochemical effects of oxytocin in people at clinical high risk for psychosis
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A new Nature Neuroscience study suggests that oxytocin modulates social value representations in the amygdala
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A new study suggests that oxytocin signalling plays a role in amygdala–hippocampal connectivity in autism
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A new study suggests that oxytocin treatment reduces food intake and body fat in an animal model of post-menopause
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A new study assesses the social salience hypothesis of oxytocin in a fish species
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A new study in Molecular Autism reports that the oxytocin receptor gene predicts brain activity during an emotion recognition task in autism
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A new study in Translational Psychiatry examines the Effect of age and autism spectrum disorder on oxytocin receptor density in the brain
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A new study demonstrates that oxytocin selectively improves empathic accuracy
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A new study demonstrates that intranasal oxytocin modulates higher order social cognition in body dysmorphic disorder
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A new study demonstrates that prefrontal cortical neurons that express the oxytocin receptor modulate social recognition
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A new study demonstrates that cortisol and oxytocin show independent activity during chimpanzee intergroup conflict
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A new replication study confirms that women’s facial masculinity preferences are predicted by the interaction between their relationship status and average progesterone levels.
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A new study in eLife suggests that oxytocin promotes coordinated out-group attack during intergroup conflict
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A new study suggests that an oxytocin-like peptide regulates behavior in ants.
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A new preprint suggests that social status in mouse social hierarchies is associated with variation in oxytocin receptor densities
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A new study suggests that oxytocin improves learning in rats
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A new study suggests that oxytocin levels are associated with impaired social cognition in schizophrenia.
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A new study identifies how oxytocin might be transported into the brain to elicit social behaviour.
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Dan summarises a new preprint that describes a study investigating whether direct nose-to-brain pathways underlie intranasal oxytocin-induced changes in regional cerebral blood flow in humans
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This an audio paper on oxytocin pathway gene networks in the human brain, published in Nature Communications.
Read the full paper here.
Links
Dan on Twitter
Dan on Instagram
This an audio paper on remedies for three common issues in meta-analysis: lack of pre-registration, misinterpretation of funnel plots, and effect size dependencies.
Read the paper preprint here.
Links
Dan on Twitter
Dan on Instagram
Here's a talk I recently gave at Leiden University on December 12th 2018. I provide an overview of HRV and its role in mental illness, which is generally characterised by reduced HRV. I will also cover how reduced HRV has important functional significance for social behaviours and psychological flexibility in response to stressors. Easy access to measuring HRV is both one of its strengths and weaknesses, so I also discuss its responsible application in biobehavioral research.
Links
Here's the slidedeck I used
I had a chat with Belinda Poole, a graduate student from the University of Sydney (my alma mater!), about her first meta-analysis. We discuss the publication of meta-analysis protocols, how to best find mistakes in your data extraction, and using the JAMOVI software package as a stepping stone to R for meta-analysis.
Links
Tutorial paper on meta-analysis
P uniform
Statcheck
R meta-analysis mailing list
JAMOVI
Video episodes on Instagram
Video episodes on YouTube
In this episode, I share an audio version of a recent paper on Bayesian alternatives for null hypothesis significance tests. Read the open access paper here.
Full reference to the paper: Quintana, D.S. & Williams, D.R. Bayesian alternatives for common null- hypothesis significance tests in psychiatry: a non-technical guide using JASP BMC Psychiatry (2018) 18: 178. https://doi.org/10.1186/s12888-018-1761-4
Links
Dan on Twitter
Dan on Instagram
I recently had a chat with Thea, a PhD student from New York University, about her first meta-analysis. We discuss the value of learning meta-analysis, the difference between publication bias and small study bias, leave-one-out analyses, using the R meta-analysis mailing list for solving problems, comparing correlations, and the benefits of Twitter when you're learning a new skill.
Links
Tutorial paper on meta-analysis
TOSTER R package
R meta-analysis mailing list
Comparing correlations
Video episodes on Instagram
Video episodes on YouTube
In this episode, I share an audio version of a recent paper on evidence for intranasal oxytocin delivery to the brain. Read the open access paper here.
Full reference to the paper: Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018). Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives. Therapeutic Delivery, 9(7), 515-525.
Links
The paper
Dan on Twitter
Dan on Instagram
In this Q&A episode, I answer a question from the #PhDchat hashtag on twitter about how many paper you should read while writing up your lit review.
Links
Original tweet with the question
Dan on Twitter
Video episodes on Instagram
Video episodes on YouTube
I chat with Sophie Betka (Brighton and Sussex Medical School, UK) about her new study on how oxytocin influences attention to internal cues in social drinkers.
You can watch the video version of this interview on Instagram TV or YouTube.
Links
The paper
Sophie on Twitter
Dan on Twitter
Dan on Instagram
Dan on YouTube
I chat with Anne Rimpel & Clarissa Zwarg (LMU Munich, Germany) about their new study on how oxytocin promotes attention to social cues.
You can watch the video version of this interview on Instagram TV or YouTube.
Links
The paper
Dan on Twitter
Dan on Instagram
Dan on YouTube
I answer a listener question from Joey on how to identify good meta-analyses when reading the literature.
Links
Dan on Twitter
Dan on Facebook
Video episodes on Instagram
Video episodes on YouTube
I recently had a great chat with Stu Murray, who is an Assistant Professor at University of California, San Francisco. We cover a few topics including how to get the most out of Twitter as an academic, his strategy for revising manuscripts, and work/life balance.
Links
Stu on Twitter
Dan on Twitter
"Show your Work" book
Human brain colouring book
Dan on Facebook
Dan on Instagram
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I chat with Sally Grace (Swinburne University of Technology, Melbourne, Australia) about her new meta-analysis of fMRI intranasal oxytocin studies.
If you're on Instagram, you can watch the video version of this interview.
Links
Sally's paper
Sally on Twitter
Dan on Twitter
Dan on Instagram
Dan on YouTube
In this Q&A episode, I answer a question from the #PhDchat hashtag on twitter about how to best convince mentors and co-authors to adopt preprints. I also share a personal preprint experience from last year that convinced me to preprint ALL my work.
Links
Original tweet
Preprint FAQ
Dan on Twitter
Video episodes on Instagram
Video episodes on YouTube
I spoke with Marian Bakermans-Kranenburg about her recent study on the impact of vasopressin on the processing of infant cries in expectant fathers.
Show links
The study
Dan on Twitter
Dan on Instagram
Dan on YouTube
I really enjoyed this chat with Josh Woolley (University of California, San Francisco) on intranasal oxytocin in psychiatry research. We talked about some of the major issues that the field of needs to address as well as some of the challenges of doing work in this area.
Links:
Josh's lab on twitter
Dan on twitter
Dan on Instagram
I speak with Matt Wall (Imperial College, London) about a new paper he co-authored on the role of kisspeptin in emotional brain processing. We chat about the results of the study and the origins of this peptide hormone.
If you're on Instagram, you can watch the video version of this interview here: https://www.instagram.com/tv/BlX8bsCFhT1/
Show links
Kisspeptin paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272173/
Matt Wall on Twitter: https://twitter.com/m_wall
Dan on Twitter: https://twitter.com/dsquintana
Dan on Instagram: https://instagram.com/dsquintana
Dan on YouTube: http://www.youtube.com/c/DanielQuintana_research
I introduce my new show and the two reasons why I started it.
In this show you'll find a mix of episodes on research that's catching my eye in psychiatry and psychology, interviews with other scientists, and me sharing my daily research process.
Links and show notes
Dan's research
Dan on Twitter
Dan on Instagram
YouTube channel