Clinical Literature Summaries presented by InpharmD™ (S3): Recent Episodes
InpharmD™
Season-3 is here! Tune in for InpharmD's podcast series, as we bring you clinical summaries and critiques of the most trending medical literature on the market.
InpharmD's EBM podcast focuses on commonly asked drug information questions and the associated literature. This episode focuses on the use of ketamine for Sickle Cell Disease.
InpharmD's EBM podcast focuses on commonly asked drug information (DI) questions and the associated literature. Everyday, our queue gets tons of questions asked by health care providers all around the country. For this episode, we assess tirzepatide for obstructive sleep apnea and analyze the SURMOUNT-OSA clinical trials.
InpharmD's EBM podcast focuses on commonly asked drug information (DI) questions and the associated literature. Everyday, our queue gets tons of questions asked by health care providers all around the country. For this episode, we assess treatment options for excoriation disorder.
InpharmD's EBM podcast focuses on commonly asked DI questions. Every day, our queue gets tons of new questions asked from providers all around the country. Today's podcast focuses on the use of phenytoin to treat tacrolimus toxicity.
InpharmD's EBM podcast focuses on commonly asked drug information questions. Every day, our queue gets tons of new questions asked from providers all around the country. One question that’s been garnering a lot of views from our users right now is which atypical antipsychotics are associated with the lowest and highest risk of QT prolongation.
Join InpharmD as we discuss the safety and efficacy of two FDA-approved RSV vaccines, Arexvy and Abrysvo.
Join us as we discuss the data surrounding newly approved antifungal agent, rezafungin. Interested in learning more? Join our CE on rezafungin on July 27th at 12:00 PM EST - open to all pharmacists!
Join InpharmD as we discuss the data on perioperative duloxetine (Cymbalta) during orthopedic surgery for pain reduction.
Interested in the full data response? Read here!
Every month, InpharmD creates a continuing-education (CE) class on the most commonly asked drug information question and the related evidence. Our podcast offers a sneak peak into our CE as we briefly discuss the topic.
Episode-2 looks at the safety and efficacy of lecanemab in the treatment of Alzheimer’s dementia.
Join us as we discuss the evidence surrounding tirzepatide for weight loss in diabetic patient populations.
Many hospitals have been dealing with the recent oxytocin shortage. With this episode, we discuss possible alternatives and adjuncts to oxytocin, based on the evidence available.
Tune in as we discuss the PROVENT trial and the on-going TACKLE trial to determine whether or not Evusheld can increase cardiovascular events.
A randomized clinical trial conducted to assess time-restricted eating with calorie restriction as compared with daily calorie restriction alone for the effects on weight loss and metabolic risk factors in obese patients.
A regression analysis conducted in Israel showed that a fourth dose appeared to increase the protection against severe illness relative to three doses that were administered more than 4 months earlier. Further studies are needed before applying this to a larger population.
A multicenter, randomized, open label, non-inferiority trial conducted to test and compare the efficacy of methenamine hippurate for prevention of recurrent urinary tract infections (UTI) with the current standard prophylaxis of daily low dose antibiotics.
A cohort study conducted to estimate the rate of breast cancer overdiagnosis in contemporary mammography practice accounting for the detection of nonprogressive cancer.
A prospective, double blind, superiority, randomized placebo-controlled trial conducted to confirm the rapid onset anti-suicidal benefits of ketamine in the short term and at six weeks.
A phase 3, double-blind, randomized, placebo-controlled trial conducted to show superiority of SER-109 in reducing the risk of C. difficile infection recurrence up to 8 weeks after treatment.
A retrospective study conducted to assess for any decrease in mortality associated with the use of the BNT162b2 (BioNTech, Pfizer vaccine) booster.
A double-blind, randomized, placebo-controlled trial conducted to evaluate the efficacy and safety of a 3-day course of remdesivir in high-risk, non-hospitalized patients with COVID-19.
A single-blind, multicenter, randomized, controlled trial conducted to evaluate the efficacy of financial incentives dependent on continuous smoking abstinence on smoking cessation and birth outcomes among pregnant smokers.
An open-label, randomized, parallel-group, adaptive design with blinded outcome adjudication trial conducted to compare the efficacy and safety of milvexian and enoxaparin in patients undergoing elective knee arthroplasty.
The first in-human, phase 1, randomized, double-blind, placebo-controlled study conducted to determine the safety, tolerability, and pharmacokinetics of single and multiple ascending oral doses of molnupiravir in healthy subjects.
A double-blind, randomized, placebo-controlled trial conducted to assess the role of chlorthalidone for hypertension in advanced chronic kidney disease.
An investigator-initiated, multi-center, randomized, double-blind, superiority, placebo-controlled conducted to determine whether the combination of vasopressin and methylprednisolone administered during in-hospital cardiac arrest improves return of spontaneous circulation.
A randomized, adaptive, platform trial conducted to assess the efficacy of fluvoxamine versus placebo in preventing hospitalization (defined as either retention in a COVID-19 emergency setting or transfer to a tertiary hospital due to COVID-19).
A randomized, double-blind, placebo-controlled, phase 3 study, conducted to evaluate the efficacy and safety MDMA-assisted therapy for PTSD compared with placebo with therapy?
A randomized, double-blind, parallel-group, placebo-controlled, event-driven trial conducted to evaluate the effects of SGLT2 inhibition with empagliflozin on major heart failure outcomes in patients with heart failure and a preserved ejection fraction.
This week, InpharmD looks at two case reports discussing presentations of patients who developed Functional Neurological Disorder (FND) after receiving COVID-19 vaccination.
This week, we look at two different case reports:
1) Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination
2) Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination
Tune in to learn more!
A cohort study conducted to determine whether there is a dose–response relationship between the intensity of exposure to the World Trade Center (WTC) site and the risk of hepatic steatosis (HS) in the WTC General Responder Cohort (GRC).
A prospective, multi-center, international cohort study conducted to evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD), Crohn’s Disease, and Ulcerative Colitis.
A double-blind, placebo-controlled, cross-over study conducted to assess the impact of childhood trauma on responses to morphine and pain processing.
A study that use supervised machine learning to identify potential variables important to assessing risk of incident chronic heart disease (CHD), stroke, and heart failure (HF) in a hypothesis-free, data-driven manner.
A study conducted to investigate the acceptability and tolerability of an intra-oral device, designed to facilitate weight loss
Here we provide an overview of three case reports focusing on patients who developed rhino-orbital mucormycosis, a rare fungal infection, potentially from COVID-19.
A multicenter, randomized, open-label, parallel-group trial conducted to determine the effectiveness of continuous glucose monitoring (CGM) in adults with type 2 diabetes treated with basal insulin.
An international, randomized, double-blind, placebo-controlled trial conducted to evaluate the efficacy and safety of semaglutide, as compared with placebo, as an adjunct to lifestyle intervention for reducing body weight in overweight and obese adults without diabetes.
An investigator-initiated, multicenter, parallel-group, open-label, randomized clinical trial conducted to determine whether continuous infusion of hypertonic saline solution improves neurological outcomes at 6 months in patients with traumatic brain injury
A global, phase-3 trial conducted to evaluate the efficacy and safety of sacituzumab govitecan (Trodelvy) as compared with single-agent chemotherapy of the physician’s choice in patients with relapsed or refractory metastatic triple-negative breast cancer. This trial led to the FDA's accelerated approval of Trodelvy for this indication.
A mutlicenter, randomized trial conducted to test whether dexmedetomidine leads to better short-term and long-term outcomes than propofol in mechanically ventilated adults with sepsis.
A randomized, multicenter, international, double-blind, placebo-controlled trial conducted to determine whether the addition of midodrine to standard care reduces the time to discontinuation of IV vasopressor use in otherwise resuscitated patients
A retrospective, multicenter, observational, database analysis conducted to quantify rates of organ-specific dysfunction in individuals with COVID-19 after discharge from hospital compared with a matched control group from the general population
A randomized, open-label, trial conducted to evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU).
A retrospective, observational, cohort study conducted to compare the rate of change in estimated glomerular filtration rate (eGFR) after hospital discharge between patients with and without COVID-19 who experienced in-hospital acute kidney injury (AKI)
A randomized study conducted to determine the effect of bamlanivimab monotherapy and combination therapy with bamlanivimab and etesevimab on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) viral load in mild to moderate COVID-19
A controlled, open-label trial conducted to report the results of the controlled, open-label Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial of dexamethasone in patients hospitalized with COVID-19.
A randomized multicenter, double-blind, parallel-group, placebo-controlled trial, conducted to investigate the effect of vitamin D3 administration on hospital length of stay and other relevant clinical outcomes and adverse events in hospitalized patients with moderate to severe COVID-19.
A randomized, multi-center, open-label, open-label, factorial clinical trial conducted to examine whether high-dose zinc and/or high-dose ascorbic acid reduce the severity or duration of symptoms compared with usual care among ambulatory patients with SARS-CoV-2 infection.
Early data suggests the incidence of true anaphylaxis to the Pfizer-BioNTech COVID-19 vaccine is rare (11.1 cases per million vaccine doses). Anaphylaxis is more common in women and persons with a history of allergies, and symptoms typically appear within 30 minutes of injection.
A retrospective, observational, cohort study done to assess whether a diagnosis of a schizophrenia spectrum disorder, mood disorder, or anxiety disorder is associated with mortality in patients with COVID-19.
A randomized, multicenter, double-blind, placebo-controlled, phase 1/2a clinical trial to evaluate the safety, reactogenicity, and immunogenicity of Ad26.COV2.S - a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike (S) protein
An observational cohort study performed to describe characteristics and outcomes of hematopoietic stem-cell transplantation (HSCT) recipients after developing COVID-19
A prospective, randomized, open-label trial performed to evaluate whether continuation of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) is beneficial or harmful in patients who are admitted to hospital with COVID-19.
A cohort study done to comparatively examine differences in risk of clinical manifestations and death among people admitted to hospital with coronavirus disease 2019 (COVID-19) and seasonal influenza.
A phase 3 randomized, stratified, observer-blinded, placebo-controlled trial to to assess the safety and efficacy of the mRNA-1273 vaccine in preventing SARS-CoV-2 infection.
A randomized, multicenter, adaptive, double-blind, placebo-controlled trial to evaluate whether the combination of baricitinib plus remdesivir was superior to remdesivir alone.
A comparative study done to evaluate the fitted filtration efficiency (FFE) of various consumer-grade and improvised face masks, as well as several popular modifications of medical procedure masks that are intended to improve mask fit or comfort.
A case report describing two monozygotic twins with different clinical courses, despite having the same environment and genomic factors.
A retrospective, cohort study conducted to determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19
A randomzied, double-blind, placebo-controlled, multicenter, phase 2, pilot trial conducted to determine whether inhaled SNG001 (recombinant interferon beta-1a) has the potential to reduce the severity of lower respiratory tract illness and accelerate recovery in patients diagnosed with COVID-19.
The purpose of this study was to evaluate the efficacy and safety of LY-CoV555 (bamlanivimab) in patients with recently diagnosed mild or moderate COVID-19 in the outpatient setting
What does the evidence says on the safety and immunogenicity of pfizer's potential vaccine - BNT162b2 - as compared to other candidates?
A cohort study examining levels of severity of depressive symptoms over time among individuals with high risk in the UK during the COVID-19 pandemic
A randomized, double-blind, placebo-controlled trial conducted to assess if early intervention with interleukin-6 receptor blockade might limit COVID-19 progression to hypoxemic respiratory failure or death, reduce the risk of clinical worsening, and decrease the duration of supplemental oxygen use.
A 25-year old male patient was infected on two separate occasions, with the second infection being symptomatically more severe than the first. Genomic analysis showed the two viral agents were genetically distinct.
The objective of this study was to evaluate the clinical efficacy and safety of remdesivir among hospitalized adults with laboratory-confirmed COVID-19.
The objective of the cohort study was to investigate the effect of serum testosterone and its relationship with other laboratory parameters on the prognosis of coronavirus disease 2019 in SARS-CoV-2 infected male patients
The objective of this study was to use the Extracorporeal Life Support Organization (ELSO) Registry to report the epidemiology, treatment, outcomes, and hospital characteristics of patients receiving extracorporeal membrane oxygenation (ECMO)with a confirmed diagnosis of Corona Virus Disease 2019 (COVID-19).
A study to determine the risk of hospitalization, mechanical ventilation, and death associated with infection; and to identify characteristics independently associated with these outcomes in patients who tested positive for severe acute respiratory syndrome coronavirus 2.
Read more: inpharmd.com/covid
What does the evidence say on the safety and immunogenicity of the new Novavax vaccine for the SARS-CoV-2 infection?
Is cell phone location data associated with the rate of change in new COVID-19 cases by county across the US? Tune in to what the evidence say.
An open-label, non-randomized, single-arm, Expanded Access Program (EAP) trial conducted to explore potential signals of efficacy of COVID-19 convalescent plasma.
Read more here: inpharmd.com/covid
A prospective, multi-center, single-blind, randomized controlled phase II trial assessing the efficacy and safety of ruxolitinib in hospitalized COVID-19 patients
A cohort study published in JAMA looks at the evidence regarding race and mortality in hospitalized patients affected by COVID-19.
Let's look at the evidence to see if progressive muscle relaxation reduces anxiety and improves sleep quality in patients affected by COVID-19.
Lopinavir/ritonavir, or Kaletra™, is an antiviral theorized to work against COVID-19. Does it?