Derms and Conditions: Recent Episodes
Foundation for Research and Education in Dermatology, LLC
Now in Season 2, Derms and Conditions is a podcast from the team that brings you the Fall Clinical and Winter Clinical Dermatology Conferences. Each episode, you'll hear from leading Dermatologists in the US as they talk about Dermatology's hottest and most relevant topics and conditions. Dermatologists all face a barrage of new information virtually every day that is difficult to keep up with and digest. In this podcast, you'll hear about clinical practice tips and treatment pearls that you can implement on a daily basis in your busy practice. Subscribe to Derms and Conditions today to stay in-the-know with the country's leading experts. Thanks for listening!
In Episode 59 of Derms and Conditions, our host, James Q. Del Rosso, DO, continues his conversation with Christopher Bunick, MD, PhD, an associate professor of dermatology at Yale University School of Medicine who performs specialized research on novel treatments and therapies. After discussing sarecycline for acne in part 1, the two switch gears to monoclonal antibodies.
Dr Bunick begins by discussing dupilumab, an IL-4 and IL-13 blocker with significant clinical efficacy and a favorable safety profile in treating atopic dermatitis (AD). He states that in a network meta-analysis, upadacitinib and abrocitinib were shown to be more effective at treating AD than dupilumab, but dupilumab was shown to be more efficacious than tralokinumab and lebrikizumab. He and Dr Del Rosso agree that despite being part of a similar class, each IL-13 blocker should be applied and understood individually. They note several cases where patients who responded poorly to dupilumab had a beneficial response to tralokinumab, despite having similar mechanisms of action.
Next, they discuss IL-13 signaling, which is increased and more persistent in tissues compared to other cytokines. However, Dr Bunick explains that IL-4 has more potent signaling, so IL-13 isn’t necessarily more clinically relevant. He notes that more research is required to further understand the structure-function mechanisms of cytokines in the cell. He then mentions the non-canonical receptor, aka the “decoy receptor”, for IL-13, which could also explain a difference in drugs within the same class. Dr Del Rosso concludes that switching from one IL-13 blocker to another in a patient who was initially unresponsive to treatment may be more favorable than escalating to an alternative class of medication.
Dr Del Rosso then discusses Dr Bunick’s recent publication that compared the adverse effects of common immunosuppressive drugs to those of upadacitinib and abrocitinib in the treatment of AD. While the study population that used the common immunosuppressives did have comorbidities outside of AD, Dr Bunick notes that the risk of adverse events still exists for those treatments in AD and is not present only in JAK inhibitors. Dr Del Rosso states that many risk factors can contribute to adverse events, and not all responsibility should be shifted to JAK inhibitors. Tune in to this episode to learn the complete details about monoclonal antibodies and JAK inhibitors!
In episode 58 of Derms and Conditions, our host, Dr James Q. Del Rosso, presents a self-made episode where he discusses some clarifications regarding commonly misunderstood therapies in dermatology. Dr Del Rosso begins by discussing the use of benzoyl peroxide (BPO) for papulopustular rosacea and notes that many providers are hesitant to use this treatment given the perceived irritant effects. He notes that the microencapsulated BPO 5% cream (FDA approved EPSOLAY®), specifically formulated to allow for the slow release of the drug in the skin, is the only formulation proven to be efficacious, safe, and tolerable in rosacea. He summarizes a 12-week study of patients with moderate to severe papulopustular rosacea in which 25% of patients were clear or almost clear at 4 weeks with total inflammation reduced by 70% at 12 weeks. In addition, he notes that the tolerability was favorable with no differences noted between the active and vehicle groups.
Next, Dr Del Rosso discusses clascoterone 1% cream, FDA approved for twice daily use for acne in patients aged 12 years and older with no limitations on duration of use. He explains findings from a recently published study that show even with the maximum use of clascoterone, 4 to 6 times greater than the normal 1-gram dose, there were no clinically significant hyperkalemia readings, adverse events, or EKG changes in any participant in the control or experimental groups. Given its topical use, negligible systemic absorption especially when used as recommended, and the findings of this study, Dr Del Rosso agrees that clinicians should be reassured about the lack of risk of hyperkalemia with clascoterone use.
Lastly, Dr Del Rosso switches focus to Janus kinase (JAK) inhibitors and biologics. He discusses where the boxed warnings for JAK inhibitors originated and why they are not as concerning overall with oral JAK inhibitors used for dermatologic indications in younger populations who exhibit fewer comorbidities and/or concomitant therapies. In addition, he notes that the risk of several side effects of special interest, such as lymphopenia, malignancy, and thromboembolic events are quite low. He also emphasizes that not all monoclonal antibodies with similar modes of action exhibit the same pharmacologic and therapeutic profiles. In a selected case where a patient with AD has an inadequate response or adverse event such as persistent conjunctivitis caused by dupilumab (which inhibits IL-13 and IL-4), case reports have shown that changing to another monoclonal antibody that inhibits IL-13 (ie, tralokinumab) can exhibit relevant efficacy without associated conjunctivitis. Ultimately, it is good for clinicians to have options and as much data as possible to differentiate their use. He concludes that although certain drugs are part of the same category or class, they all have differences in pharmacokinetics, and the benefits and differences of each drug must be understood to optimize treatment selection for individual patients.
Tune in to this episode to learn all the valuable clinical pearls surrounding many commonly confused therapies!
In episode 57 of Derms and Conditions, our host, James Q. Del Rosso, DO, sits down with Christopher Bunick, MD, PHD, an associate professor of dermatology at Yale University School of Medicine who performs specialized dermatologic research utilizing x-ray crystallography and other novel techniques. The 2 discuss research findings surrounding new information on properties that differentiate the activity of antibiotics, with specific data on how narrow spectrum activity with sarecycline differs from the broad-spectrum tetracyclines we use in dermatology. There are new data described by Dr Bunick and his team on how the unique molecular structure of sarecycline targets Cutibacterium acnes (C. acnes) through multiple mechanisms of action, making it less vulnerable to antibiotic resistance. Dr Del Rosso begins by introducing sarecycline, a major new antibiotic in dermatology, and has Dr Bunick discuss some of his research on the medication. Dr Bunick explains how the recent scientific findings on the biochemistry of sarecycline translate clinically and have allowed us to not only advance our understanding of sarecycline but also other tetracyclines, including minocycline and doxycycline. Drs Del Rosso and Bunick follow this up by agreeing on the importance of dermatologists having a strong understanding of tetracyclines given their prevalence and frequency of use in clinical practice. Next, they switch focus to C. acnes, and Dr Bunick discusses his new findings on the ribosomal structure of C. acnes through the use of cryo-electron microscopy and how tetracyclines interact with it. Dr Bunick’s research group found that sarecycline binds C. acnes at both the 30S ribosomal subunit and a new additional ribosomal binding site, which had not previously been discovered. In addition, Dr Bunick notes how these variations in the mechanism of action can explain why tetracycline antibiotics have different properties, such as side effect profiles, despite being in the same chemical class. Drs Bunick and Del Rosso further solidify this point by explaining how similar research has established differences between PDE4 inhibitors such as roflumilast. Finally, they discuss antibiotic resistance in acne and how clinicians can better select therapies. Dr Bunick explains that sarecycline has the lowest rate of antibiotic resistance amongst tetracyclines because it targets C. acnes through 2 ribosomal binding sites and has an mRNA interfering carbon side chain that no other tetracycline possesses. Overall, Drs Bunick and Del Rosso agree that there is substantial scientific evidence on the effectiveness of sarecycline that supports its use by clinicians. Tune in to this episode to learn more about the new developments on antibiotics being discovered at a molecular level in the treatment of acne!
In episode 56 of Derms and Conditions, our host James Q. Del Rosso, DO, sits down with Marc Serota, MD, a dermatologist in private practice in Denver who is triple board certified in dermatology, allergy and immunology, and pediatrics and serves as an adjunct faculty at the University of Colorado. The 2 discuss teledermatology and how Dr Serota uses it to increase access to care and develop additional revenue streams. They begin by recounting how teledermatology became as widespread as it is and its evolution during the COVID-19 pandemic. Even though its use has slowed down as people have returned to in-person visits, Dr Serota shares his reasons that it will remain a valuable asset to clinicians for years to come. Next, Dr Del Rosso voices the concerns of many physicians regarding diagnostic limitations with telehealth and liability concerns if you do not do a full exam. Dr Serota points out that there has never been a successful malpractice lawsuit due to misdiagnosis in telehealth, and you can avoid problems by setting expectations and discussing limitations with the patient in advance. Finally, Dr Serota shares his tips and pitfalls for incorporating teledermatology into your practice. Whether you want to add in a few telehealth visits to your practice or completely transition to remote work, this episode is filled with pearls to help you get started.
In episode 55 of Derms and Conditions, our host James Q. Del Rosso, DO, sits down with Guy Webster, MD, PhD, FAAD, a clinical professor of dermatology at Jefferson Medical College. The 2 discuss new developments in the pathophysiology and management of acne as well as key pearls and pitfalls when using topicals, antibiotics, and isotretinoin. Dr Del Rosso begins by asking Dr Webster about any major changes to acne dogma over the last few decades. Dr Webster points out that while our knowledge is constantly evolving, our understanding of acne hasn’t changed as drastically as it has for diseases such as psoriasis. We know the 4 common pillars for acne pathophysiology, and we know the immune system is involved. The main mistake we have made is placing too much weight on newer data and ignoring older, equally robust data. Next, they switch focus to antibiotics, and Dr Del Rosso asks about their role in acne management. Dr Webster finds topical antibiotics such as erythromycin and clindamycin ineffective as monotherapy due to drug resistance. However, benzoyl peroxide has not been shown to create resistance and therefore remains very effective. They also discuss oral antibiotics and some of the newer narrow-spectrum options like sarecycline. Dr Del Rosso then asks Dr Webster about a hypothetical but very common case of a patient with moderate acne and how he would approach treatment. Dr Webster states that he disagrees with stepwise therapy and believes you should use your clinical experience to start with the right medication, right away. You should also identify what the patient’s goals are and recognize what they are willing to tolerate with regard to treatments. He notes that after about 4 to 6 weeks of treatment, he can tell if a therapy is having a beneficial effect or if he needs to recommend a stronger option. Finally, they discuss isotretinoin and key considerations surrounding its usage. Tune in to this episode to learn more!
In episode 54 of Derms and Conditions, our host James Q. Del Rosso, DO, sits down with Raja Sivamani, MD, MS, AP, a board-certified dermatologist who practices at the Pacific Skin Institute and runs the Integrative Dermatology Symposium through LearnSkin. They discuss the concept of integrative dermatology, which involves uniting principles from pharmaceuticals, diet, nutrition, supplements, and probiotics to deliver holistic care. Dr Del Rosso begins by asking how to learn more about the science and evidence behind specific supplements and diets. Dr Sivamani advises starting with medical literature and evaluating publications with a search of PubMed or even Google. He suggests specific integrative medicine journals such as the Journal of Integrative Medicine and the Journal of Complementary and Integrative Medicine. However, he notes that even the Journal of the American Academy of Dermatology and British Journal of Dermatology will publish on nutrition and cosmeceuticals. Regarding social media posts or blogs, Dr Sivamani advises considering the source–is it a board-certified dermatologist or a local beauty educator? Next, Dr Sivamani discusses how to counsel patients on the evidence behind making certain holistic changes using atopic dermatitis as an example. Even for his naturopathic patients, he can obtain their consent to start a biologic or other systemic medication by discussing how to approach their symptoms from multiple facets. This can be particularly helpful for conditions such as acne where patients are often concerned with what they are eating. Tune in to this episode to learn more about integrative dermatology and how you can incorporate it into your practice.
In episode 53 of Derms and Conditions, our host James Q. Del Rosso, DO, continues his conversation with Matt Zirwas, MD, a dermatologist in Columbus, Ohio, and founder of the Bexley Dermatology Research Clinic. After reviewing localized eczematous dermatitis in part 1, they switch gears to discuss adults with scattered eczematous dermatitis in part 2. Dr. Zirwas shares several pearls for differentiating among atopic dermatitis, psoriasis, photosensitive dermatitis, CTCL, and contact dermatitis, and describes a new method for diagnosing scabies. He also discusses when to perform a biopsy and management approaches when the biopsy does not provide a clear answer. Dr. Zirwas then names several topical products with low allergenicity, including everything from cleansers and moisturizers to detergents and fabric softeners, that are beneficial to patients with sensitive skin. Dr. Del Rosso asks about disease-directed therapy and systemic treatment options, prompting Dr. Zirwas to dive into his medications of choice for each phenotype and patient population. This episode is full of pearls for a variety of eczematous and inflammatory dermatoses, so tune in to learn more!
In Episode 40 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with Whitney A. High, MD, JD, a Professor of Dermatology and Pathology at the University of Colorado. The two discuss blastic plasmacytoid dendritic cell neoplasm (BPDCN), a highly aggressive and fatal malignancy that can be very challenging to diagnose.Dermatologists are in a great position to make the initial diagnosis of this rare disease as it involves the skin in 80-90% of cases. Dr. High discusses several clinical pearls about BPDCN including how it presents, important considerations for the dermatopathologist, and the best techniques to biopsy the lesion in order to maximize diagnostic yield. Finally, he reviews the next steps in disease management once the diagnosis is made. Dermatologists can have a significant impact on patient outcomes with BPDCN by making the diagnosis early, so tune in to this episode to learn more!
In episode 39 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with Jennifer Cather, MD, a dermatologist and Medical Director at Mindful Dermatology and Modern Research Associates in Dallas, Texas, and a good friend of Dr. Del Rosso. Dr. Cather is an expert in psoriasis as she is currently managing over 1,700 patients on systemic therapy. She and Dr. Del Rosso discuss the exciting new Mind.Px test, a dermal biomarker patch developed by Mindera Health that can noninvasively obtain a sample of a patient’s transcriptome to help determine which biologic they will optimally respond to. Dr. Cather describes how Mind.Px can limit trial-and-error through a targeted approach. Many patients lose faith in psoriasis medications after multiple treatment failures, so data from this test can uncover which drug class, either TNF-inhibitors, IL-17 inhibitors, or IL-23 inhibitors, will work best for them. Precision medicine is a hot new topic with a lot of new information to navigate, so tune in to this episode to learn Dr. Cather’s tips on using the Mind.Px test to improve your psoriasis patients’ outcomes!
In Episode 38 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with Chris Bunick, MD, PhD, an Associate Professor of Dermatology at Yale University. The two discuss the important topic of antibiotic stewardship in Dermatology. Dr. Bunick begins by sharing his unique background and how he became interested in structural biology and the way medications work at a molecular level. Once he discovered his passion for Dermatology, he turned his attention to understanding antibiotics and how resistance develops. In this episode, he reviews new data on the effects antibiotics have on our microbiome and overall health. He also discusses sarecycline and how its unique properties compared to other tetracyclines help limit resistance and adverse effects. Since Dermatologists prescribe more antibiotics than any other specialty, this is definitely an episode you won’t want to miss!
In episode 37 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with April W. Armstrong, MD, MPH and David E. Cohen, MD, MPH live at Fall Clinical 2022 in Las Vegas, NV to discuss highlights from the meeting. This is a very unique episode of Derms and Conditions filled with clinical pearls for four conditions! Dr. Armstrong discusses two biologics that have great data for prurigo nodularis as well as a new topical JAK inhibitor for vitiligo. Dr. Cohen highlights some advances for atopic dermatitis while revealing the highly anticipated 2023 allergen of the year. Finally, the two share their thoughts on the landmark approval of deucravacitinib for psoriasis. Don’t miss hearing our KOLs discuss its novel mechanism, efficaciousness, and safety profile so that you can confidently answer your patients’ questions about this new therapy. Tune in today!
In episode 36 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with Linda Stein Gold, MD, the Director of Dermatology Clinical Research and Division Head of Dermatology at Henry Ford Health. The two discuss various topical treatment options in the management of psoriasis. Dr. Stein Gold begins by reiterating that despite the development of new systemic therapies, topical therapy remains a mainstay in psoriasis management. She discusses a new formulation of betamethasone dipropionate that uses an emollient spray to deliver the corticosteroid into the superficial aspects of the skin while limiting deeper penetration and systemic absorption. Another option to limit adverse effects is decreasing the concentration of the corticosteroid, and Dr. Stein Gold describes a clinical trial that compared clobetasol 0.025% and 0.05% and showed that the lower concentration had similar efficacy but a much better safety profile. This episode is filled with clinical pearls for treating psoriasis and improving patient outcomes.
In episode 35 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with Dee Anna Glaser, MD and her two daughters, Katherine and Ella. Many in the Dermatology community know Dr. Glaser as she is very involved at conferences and is a leader in hyperhidrosis. But many may not know that both of her daughters are also dermatologists. The three of them share their path to dermatology and how they independently discovered their passion for the field. In this episode we diverge from the usual discussion of clinical conditions and get a unique view into the Glasers’ family dynamic and the impact that dermatology has had on these brilliant women.
In Episode 34 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with Joslyn Sciacca Kirby, MD, MEd, MS, who is an Associate Professor of Dermatology at Penn State Health. The two discuss Hidradenitis Suppurativa and the difficulty that they, along with many Dermatologists, face in treating it. They begin by pointing out all of the treatment modalities that have historically been used and how some are still effective, while others should be retired, especially when facing severe or refractory disease. Dr. Kirby then shares some of her preferred topical and systemic therapies and how to select the right drug for the right patient. Finally, she relays that there is hope for the future in treating HS, as she personally participates in clinical trials for new monoclonal antibodies that have shown promising results. You don’t want to miss this episode filled with pearls on treating one of the most stubborn dermatologic conditions.
In episode 33 of Derms and Conditions, our host James Q. Del Rosso, DO sits down with April W. Armstrong, MD, MPH, Professor of Dermatology and Associate Dean at the University of Southern California. The two discuss the Janus tyrosine kinase (JAK) pathway and how JAK inhibitors have become a useful tool in treating several chronic dermatologic conditions. Dr. Armstrong notes that different members of the JAK family pair in different ways and therefore enhance different intracellular signals. In fact, these pairings are why certain JAK inhibitors are used for certain disease states and subsequently lead to a variety of adverse effects. Dr. Armstrong emphasizes the importance of knowing which JAK molecule the drug acts upon and the associated side effects for clinical monitoring. She highlights that one member of the JAK family, TYK2, can have a more targeted effect based on where the molecule is inhibited and therefore lead to fewer adverse effects. She goes on to discuss an example of a common case encountered in practice and some of the relative and absolute contraindications to starting a JAK inhibitor. You won’t want to miss these important pearls that can help you navigate this complex but exciting area of therapeutics.
In episode 32 of Derms and Conditions, our host James Q. Del Rosso, DO chats with Dr. Brad Glick, who is the residency program director at Larkin Palm Springs in Miami as well as a close friend of Dr. Del Rosso. Dr. Glick and Dr. Del Rosso discuss the advantages of topical therapies and their pivotal role in managing chronic diseases, even in the setting of significant advances in targeted systemic therapy. Dr. Glick emphasizes that the adjunctive use of topical and systemic therapies is key to obtain and maintain clearance. They then specifically discuss the new combination of betamethasone dipropionate and calcipotriene cream and the unique formulation used to deliver the two very different medications effectively and synergistically. Finally, Dr. Glick weighs in on the age-old debate: New York or Chicago style pizza?
In this episode of Derms & Conditions, James Q. Del Rosso, DO gleans up-to-date practical information on hair loss from Natasha Mesinkovska, MD, PhD, based on her extensive clinical and research experience in this area of dermatology. Several entities and challenges are discussed with tips on both diagnosis and management. The latter half focuses on alopecia areata, including its relationships to both atopy and autoimmune disease. The episode concludes with how Dr. Mesinkovska integrates oral JAK inhibitors into her management plan. This discussion is loaded with pearls!
In Episode 30 of Derms and Conditions, host James Q. Del Rosso, DO speaks with Joseph F. Merola, MD, MMSc, a board certified rheumatologist and dermatologist who is an Associate Professor of Dermatology at Harvard Medical School. Dr. Merola and Dr. Del Rosso first discuss the diagnosis and management of cutaneous lupus with a special focus on drug-induced lupus. Next, Dr. Del Rosso asks Dr. Merola about dermatomyositis including tips on diagnosis and which laboratory tests are best to order. Finally, Dr. Merola ends the episode with a focus on psoriatic arthritis, including key diagnostic tips to help differentiate it from other arthritic disorders.
In Episode 29 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with Peter Lio, MD, Clinical Assistant Professor of Dermatology and Pediatrics at Northwestern University in Chicago, IL. The episode begins with Dr. Del Rosso asking Dr. Lio about useful patient questionnaires that he uses in his practice. Dr. Lio then discusses his use of the ADCT (Atopic Dermatitis Control Tool) which helps assess the waxing/waning nature of the disease. Next, Dr. Lio discusses his use of alternative medications in dermatology and the criteria he uses for selection of these therapies. Specifically, the use of coconut oil is highlighted. Dr. Lio ends the episode by offering some tips on how to select the appropriate patient and properly counsel them on JAK Inhibitors for the treatment of Atopic Dermatitis. Finally, don't miss the ending where we learn about Dr Lio's passion for Pizza, his crust preference, and which pizza place in the US has 'changed his life'.
In Episode 28 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with Ted Lain MD, MBA, who is the Chief Medical Officer at Sanova Dermatology. During this episode, Dr. Lain shares how he became interested in the business of dermatology early in his career, along with his consistent dedication to being a very knowledgeable and competent dermatologist. He offers some available resources for dermatologists who want to become better educated in the business area. The discussion emphasizes the central importance of quality patient care in any business model of dermatological practice. Finally, Dr. Lain offers some important tips and considerations for new dermatologists who are entering into practice.
In Episode 27 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with Gary Goldenberg, MD who is in Private Practice in New York, NY and serves as Assistant Clinical Professor of Dermatology at The Icahn School of Medicine at Mount Sinai Hospital. Dr. Del Rosso and Dr. Goldenberg spend the episode discussing precision medicine in the field of dermatology. Dr. Goldenberg discusses his use of electric impedance spectroscopy technology on his decision to biopsy pigmented skin lesions that are suspicious for melanoma. Next, Dr. Goldenberg discusses the use of precision medicine in helping to select the correct psoriasis biologic. Dr. Goldenberg stresses that precision medicine is a useful tool in dermatology but decisions must be made in conjunction with clinical judgment. The episode ends with Dr. Del Rosso highlighting some of the advantages precision medicine may have in selecting biologic medications for psoriasis.
In Episode 26 of Derms and Conditions, our host James Q. Del Rosso, DO talks with board-certified dermatologist Sandra S. Lee, MD who is well known as “Dr. Pimple Popper”, a global social media and television star. Dr. Del Rosso starts by asking Dr. Lee about her family background related to dermatology. The discussion moves to later in her career when as a practicing dermatologist she fortuitously found her way within the world of being a "star" on social media and TV. While Dr. Lee embraced this opportunity, it was not without its challenges. Dr. Lee addresses how she controlled blending her media life and image with her active dermatology practice and how she dealt with certain challenges and criticisms that she faced along the way. Their discussion concludes with highlighting an important area of education in office-based surgery that Dr. Lee is passionate about: practical and effective use of tumescent anesthesia by dermatologic surgeons for large surgical excisions.
In Episode 25 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with Leon H. Kircik, MD, a Clinical Professor of Dermatology at the Icahn School of Medicine at Mount Sinai in New York City who also has a private practice in Louisville, Kentucky. Throughout the episode, Drs. Del Rosso and Kircik discuss topical therapy of psoriasis. Specifically, Dr. Kircik highlights why the vehicle matters when choosing a topical therapy and why topical therapy is still important in the current clinical landscape. Additionally, Drs. Del Rosso and Kircik discuss different formulations of topical therapies along with their advantages and disadvantages.
In Episode 24 of Derms and Conditions, our host James Q. Del Rosso, DO talks with Julie C. Harper, MD who is in private practice in Birmingham, AL and is a recent past-President of the American Acne and Rosacea Society. Dr. Del Rosso and Dr. Harper spend the episode discussing important considerations in the diagnosis and treatment of rosacea. Emphasis is placed on noting the sources of facial redness in rosacea so that treatment selection can be optimized. Dr. Harper includes practical tips for treating a rosacea patient who presents with both persistent facial erythema and papules/pustules and concludes the episodes presenting her “STOP” mnemonic when seeing a rosacea patient in the office.
In Episode 23 of Derms and Conditions, our host James Q. Del Rosso, DO talks with Patricia Farris, MD who is in practice in Old Metairie, Louisiana. Dr. Farris begins the episode discussing tips on how to build a successful aesthetic dermatology practice. She also offers helpful tips on office dynamics. Dr. Del Rosso asks Dr. Farris to give some advice on how to sell skin care products in a clinical practice setting. The episode ends with Dr. Farris discussing important considerations when selling a dermatology practice to a private equity group.
In Episode 22 of Derms and Conditions, our host James Q. Del Rosso, DO talks to Nicholas Brownstone, MD who is a fellow at the National Society for Cutaneous Medicine and managing editor of SKIN: The Journal of Cutaneous Medicine. Dr. Brownstone presents some helpful information about SKIN and highlights the benefits that it can provide to the busy, practicing dermatologist. Dr. Del Rosso asks Dr. Brownstone to review some key articles in the journal's history which includes topics such as "maskne" and the effect of diet on hidradenitis suppurativa. Dr. Brownstone spends the next part of the episode discussing his recent clinical management recommendations article on delusions of parasitosis. He offers some tips and tricks to help dermatologists manage these often difficult patients. Finally, the episode ends with Dr. Brownstone discussing some exciting new updates with the journal. This is an episode you won't want to miss!
In episode 21 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with Mark Lebwohl, MD, Dean for Clinical Therapeutics and Chairman Emeritus at Icahn School of Medicine at Mount Sinai. Dr. Lebwohl discusses field treatments of actinic keratosis (AK). He also discusses the benefits and disadvantages of imiquimod, 5-FU and tirbanibulin. Specifically, the anticipated reactions of topical AK treatments are highlighted. Advice on medication coverage is discussed next. After the patient receives the medication, Dr. Lebwohl ends the episode by giving some tips on treatment with topical AK therapies.
In episode 20 of Derms and Conditions, host James Q. Del Rosso, DO speaks with Lisa Swanson, MD and has given her the moniker, "The Adele of Dermatology". Dr Swanson spends the episode discussing many high yield and practical tips when treating pediatric dermatology patients. She first discusses her favorite treatment for warts, including how to treat warts of both the hands and face. Next, Dr. Del Rosso asks Dr. Swanson how she counsels parents about changing nevi in their children. She continues with her tips on counseling parents on sunscreen use in children. She ends the episode with a discussion of the use of propranolol in the treatment of pediatric hemangiomas and emphasizes how clinically safe this treatment is.
In episode 19 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with David Cohen, MD, MPH and April Armstrong, MD, MPH in front of a live audience during the 2022 Winter Clinical Dermatology Conference from Koloa, Hawaii. Dr. Del Rosso asks his two guests what they thought were the highlights from the many great lectures delivered at this meeting. Dr. Cohen discusses updates in the treatment of Chronic Spontaneous Urticaria and specifically mentions the use of omalizumab.
Dr. Armstrong highlights a new cream based formulation of calcipotriene-betamethasone and two new non-steroidal topical options for the treatment of psoriasis in the pipeline. Dr. Armstrong also highlights pearls from Dr. Kirby's lecture on HS including the use of antibiotics and proper injections techniques for steroids.
The episode ends with Dr. Cohen's discussion of the allergen of the year and Dr. Armstrong's discussion on the use of oral minoxidil in the treatment of hair loss.
In episode 18, our first episode of Season 2 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with Jason Hawkes, MD, MS, FAAD, who is an Associate Professor of Dermatology at the University of California, Davis. Dr. Hawkes discusses his unique background and he offers advice to early career and resident dermatologists regarding building a successful career. Dr. Hawkes stresses that his basic science and clinical trials background has made him a better clinician. The episode ends with discussion of a difficult dermatology case and Dr. Hawkes highlights the importance of interdisciplinary care.
Get ready for Season 2 of Derms and Conditions where you'll hear from leading Dermatologists in the US as they talk about Dermatology's hottest and most relevant topics and conditions. New episodes will drop early 2022.
Episode 17 of Derms and Conditions has our host James Q. Del Rosso, DO speaking with April Armstrong, MD, MPH, Professor of Dermatology at The University of Southern California. In this episode, Dr. Del Rosso and Dr. Armstrong discuss high yield pearls in managing difficult and treatment resistant cases of atopic dermatitis and psoriasis.
Specifically, they discuss bridging a patient to dupilumab with cyclosporine, how to effectively switch between different biologic therapies for psoriasis, and how to use apremilast effectively in patients with severe psoriasis. Finally, Dr. Del Rosso asks Dr. Armstrong about best practices for vaccination in patients on oral and biologic therapies for psoriasis and atopic dermatitis.
Episode 16 of Derms and Conditions has our host James Q. Del Rosso, DO speaking with Matthew Zirwas, MD about pruritus. First, Dr. Zirwas discusses the topical treatment of pruritis and offers a unique combination topical regimen that he often uses for his patients. He also presents some tips and tricks for treating Pruritus Ani. Drs. Del Rosso and Zirwas also discuss a new non-steroidal, topical agent for pruritus. Dr. Zirwas discusses, in detail, the hypothesized mechanism of action for this novel agent and shares his success using it in his clinic. Finally, he briefly mentions some alternative oral agents for the pruritic patient.
Episode 15 of Derms and Conditions, has our host James Q. Del Rosso, DO speaking with Anthony Rossi, MD, a Mohs Surgeon at Memorial Sloan Kettering Cancer Center in New York City. First Dr. Rossi discusses the use of the AJCC and Brigham and Women's Hospital squamous cell carcinoma staging system. Next Dr. Del Rosso asks Dr. Rossi for tips on treating keratoacanthomas of the lower extremities with subcutaneous methotrexate. Finally, Dr. Rossi discusses the use of immunotherapy in treating squamous cell carcinoma.
Episode 14 of Derms and Conditions, has our host James Q. Del Rosso, DO speaking with George Han, MD, PhD, Associate Professor in the Department of Dermatology at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell. First Dr. Han discusses a treatment tip for the management of pyogenic granulomas in children, then he addresses questions about biologic therapy for psoriasis. Topics include the use of adalimumab during surgery, risk of TB reactivation, and risk of malignancy. Dr. Han ends the episode by sharing his experience with telemedicine and how dermatologists can help shape its uncertain future.
Live from The Wynn Hotel and Casino in Las Vegas, NV, episode 13 of Derms and Conditions, has our host James Q. Del Rosso, DO speaking with Bruce Strober, MD in person at the 2021 Fall Clinical Dermatology Conference. First Dr. Strober discusses older biologic agents in psoriasis and how JAK inhibitors offer improved efficacy while not compromising on safety. Dr. Strober further discusses in depth how certain JAK inhibitors interact with TYK2 and what he thinks are the most important points regarding this pathway in psoriasis pathophysiology. Finally, Dr. Strober discusses in detail why allosteric binding offers improved specificity in JAK inhibition.
In episode 12 of Derms and Conditions, host James Q. Del Rosso, DO speaks with Brent Moody, MD about basal cell carcinoma. Dr. Moody discusses the importance of reviewing the pathology when treating a basal cell carcinoma, especially if significant inflammation is present. Dr. Moody also discusses the use of hedgehog inhibitors and the role they play in the treatment. He reviews indications, side effects, and important pearls when teaching medical students and residents about the surgical and medical treatment of basal cell carcinoma.
In episode 11 of Derms and Conditions, our host James Q. Del Rosso, DO speaks with Seemal R. Desai, MD regarding important points with chemical peels and other procedures performed on patients with skin of color. Dr. Desai discusses tips and methods for using chemical peels on patients with skin of color including advantages of certain chemical compounds, the use of chemical peels with topical acne medications and how to counsel patients about expectations and downtime. He further discusses best practices for performing a chemical peel in different Fitzpatrick skin types and which conditions respond best. The episode concludes with Dr. Desai discussing a few new updates on the treatment of Vitiligo.
James Del Rosso, DO discusses topical management for psoriasis and a new formulation including vehicle differentiation, efficacy, and safety.
In episode 9 of Derms and Conditions, James Del Rosso, DO speaks with Emmy Graber, MD, MBA regarding acne and rosacea. Dr. Graber provides tips on how to manage persistent erythema associated with acne using a pulsed-dye laser. Treatment for acne scarring is also discussed and Dr. Graber shares some tips and tricks for treating sequelae of acne. Dr. Del Rosso asks Dr. Graber how she integrates physical and medical treatments for rosacea and residual erythema associated with rosacea. Finally, Dr. Graber shares an in office pearl which involves the use of a hair dryer and a pulsed dye laser.
In episode 8 of Derms and Conditions, our host James Del Rosso, DO speaks with Neal Bhatia, MD regarding barriers to sunscreen use and offers tips on how to counsel patients on sunscreen use and photoprotection.
Dr. Del Rosso and Dr. Bhatia also discuss the optimal use of photodynamic therapy for actinic keratoses, both pre-procedural and post-procedure. Finally, Dr. Del Rosso poses an intriguing question and Dr. Bhatia shares a very important clinical pearl for management of dermatological issues in the Emergency Room.
In Episode 7 of Derms and Conditions, our host James Del Rosso, DO talks with Adam Friedman, MD, Professor and Chair of Dermatology at The George Washington University School of Medicine & Health Sciences on the use of topical CBD in dermatology and the use of oral spironolactone in breast cancer patients. Dr. Del Rosso and Dr. Friedman discuss many diverse topics on CBD including FDA regulations, counseling patients, and clinical studies on topical CBD gel in the treatment of xerosis and atopic dermatitis. They further discuss evidence regarding the risk of oral spironolactone in breast cancer recurrence along with effective ways to manage and counsel patients who have a personal or family history of breast cancer.
In this episode, James Del Rosso, DO talks to Matthew Zirwas, MD about some very practical pearls for prevention, clinical diagnosis, and management of contact dermatitis, especially in the absence of patch testing. Drs. Del Rosso and Zirwas discuss the origins of latex allergies and clinical patterns to recognize in hand, scalp, and face dermatitis, as well as some of Dr. Zirwas' favorite products for sensitive skin, including gloves for patients and medical professionals, deodorants, antiperspirants, hair coloring, and soaps.
In this episode, James Del Rosso, DO talks with Zoe Diana Draelos, MD about topical management of common skin wounds encountered in office practice, formulation characteristics, some basic do’s and don’ts, and details about data with Aquaphor.
In this episode of Derms and Conditions, Gary Goldenberg, MD interviews Amy McMichael, MD, Professor and Chair of Dermatology at Wake Forest University School of Medicine and Co-Chair of the Skin of Color Society Scientific Committee. She breaks down how to take personal and professional relationships to the next level to have a fulfilling career, and provides some valuable clinical pearls as well. Dr. McMichael has found that dermatology is full of wonderful relationships, and that this camaraderie has been the foundation for her success in mentoring residents, students, and even patients. “If you support people, and you make them know that you are confident in their ability […] they do infinitely better.” said Dr. McMichael. “If you want to have a really invigorating career that’s rewarding, you feed [them] and they feed you.”
In this episode, James Del Rosso, DO and Dawn Sammons, DO discuss frequently encountered clinical challenges in everyday practice with patients including chronic hair loss in women, application of topical lovastatin and cholesterol for Porokeratosis, and more.
In Part 2 of our conversation, James Del Rosso, DO and David Cohen, MD discuss the use of currently available and new systemic therapies for Atopic Dermatitis and Psoriasis. All that and a lot more in this episode of Derms and Conditions.
For more information, visit https://fallclinical.health/derms-and-conditions-podcast-episode-02
David Cohen, MD Vice Chair for Clinical Affairs and the Charles C. And Dorothea E. Harris Professor of Dermatology NYU Langone Health New York, NY
James Q. Del Rosso, DO Co-director Adjunct Clinical Professor (Dermatology) Touro University College of Osteopathic Medicine Henderson, NV
In this episode, James Del Rosso, DO and David Cohen, MD discuss the use of COVID-19 vaccines in patients on systemic therapies and review in detail how to sort through the large volume of information on the use of currently available and new therapies for atopic dermatitis and psoriasis. All that and more in this episode of Derms and Conditions. For more information, visit https://fallclinical.health/derms-and-conditions-podcast-episode-01
David Cohen, MD Vice Chair for Clinical Affairs and the Charles C. And Dorothea E. Harris Professor of Dermatology NYU Langone Health New York, NY
James Q. Del Rosso, DO Co-director Adjunct Clinical Professor (Dermatology) Touro University College of Osteopathic Medicine Henderson, NV
Derms and Conditions is a new podcast from the team that brings you the Fall and Winter Clinical Dermatology Conferences. Each episode you'll hear from leading Dermatologists in the US as they talk about Dermatology's hottest and most relevant topics and conditions. Dermatologists all face a barrage of new information virtually every day that is difficult to keep up with and digest. In this podcast, you'll hear about clinical practice tips and treatment pearls that you can implement on a daily basis in your busy practice. Subscribe to Derms and Conditions today to stay in-the-know with the country's leading experts. Thanks for listening!