Druggist For The People: Recent Episodes
Donald Schoeff R.Ph.
Four score and seven minutes ago (about an hour and a half) your physician brought forth, upon her desk, a new prescription, conceived in best medical practice, and dedicated to the proposition that all generics are created equal. Now we are engaged in a great civilian war, testing whether that medication, or any medication so conceived, and so dedicated, can help us long endure. And maybe we can feel good at the same time. For forty years as a pharmacist, I've been building bridges - from the doctor to those in need of important drug information - you. With respect for the listener, and from the perspective that it is better to apply a recommended course of therapy than it is to comply with an ordered course, the goal here is not to provide specific answers about your drug therapy, but rather to help you generate the questions that will that will empower you in this. Toward that end, there will be weekly podcasts, very often with guests who will be "the people".
Send us Fan Mail
Summary: Who hasn’t had a rash? This episode looks at the available steroid creams (Corticosteroids – not anabolic), broken down by their potency and possible indications for use. And as with every other medication on the market, there are potential side effects, which mandates the Risk-Benefit discussion. Knowing the trigger, which may include stress, for the rash and the proper use of a topical steroid treatment is the road to the best treatment. A reminder: just because it’s a topical treatment doesn’t mean it’s not a potent medication.
Topics:
· OTC Hydrocortisone Cream & Ointment 01:30
· Occlusives 02:30
· Mechanism of Action 03:20
-
Reduce inflammation
-
Suppress immune response
-
Reduce cell turnover
-
Constrict blood vessels
· 7 Classes of Topical Steroid Potency 06:00
· Where are You on the continuum? 07:00
· Indications 10:00
· Risk-Benefit (side effects) 13:00
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary:
This podcast addresses the overlap seen in depression and psychosis, and how the second generation antipsychotic meds have expanding FDA-approved indications.
Topics:
· This little light of mine 01:10
· Advertising through you 02:20
· Dopamine 04:00
· Homeostasis-Balance 04:50
· Participate & Communicate 07:00
· Decreased Dopamine 08:15
-
Parkinsons
-
Restless Leg Syndrome
· Dopamine Receptors
· Increased Dopamine 12:00
- Schizophrenia
· 1st and 2nd Generation Antipsychotics 14:00
· Side Effects 14:40
· Risk-Benefit 15:20
· Extrapyramidal Symptoms 16:15
· Relapse decrease with Caplyta 17:30
· Internet Gaming Disorder 20:00
· Caplyte 25:15
· 5 Steps of Drug Development 28:00
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: The right medication at the right dose at the right time, with the patient actively participating in that choice, may provide an incredible benefit. But there are many ways to change your chemistry, amongst them being laughter and music, two essential ingredients of a good party. Genuine Laughter stimulates your heart, lungs and muscles while also increasing the endorphins in your brain. Stress is also diminished. And so it goes for the right music, the long-term effects including improved immune system, pain relief, and lessened stress, depression and anxiety. Whether meds are included in your regimen or not, adding a good-hearted laugh and the right music to your day generally carries wonderful benefits and very little risk.
Topics:
· Bag of Chemicals? 02:00
· Music Categories & Effects 03:00
· Risks 04:00
· Science & Studies (Music & Mind/Body) 05:10
· Laughter & Mood/CV Benefits 06:00
· Thalmocortical dysrhythmia — a disorientation of rhythmic brain activity involving the thalamus and the outer cortex
Parkinson's, fibromyalgia and possibly even Alzheimer's
- Vibroacoustic therapy. 06:30
· Drumming Circles 07:10
· Post-Natal Depression (singing with baby) 07:50
· Medically Compounded Songs – for Seizures/Parkinsons/Depression? 13:40
· Contraindicated Music & Songs 14:50
· Music & Colors & Moods 16:20
· Too Much of one Style? 16:50
· AI Data Centers’ Hum – Disrupting Nature, and us? 17:30
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: Politics and opinion in healthcare is full of bias, which obscures objective truth. This podcast calls for calm, evidence based medicine, following the most reliable data. And as usual, a reminder for the patient to participate in their care, sharing in decision making with their healthcare team.
Topics:
· Keep Medicine out of Politics 01:50
· Bias = Opinion 02:45
· Mental Health Crisis 03:30
· Prevalence 04:00
· Housing Instability 05:00
· Overuse of Psychiatric Medications 07:15
· Cause of Mental Health Crisis 09:45
· Heavy Social Media Use 11:45
· Participate in Your Care 13:00
· Heroin and SSRI’s 14:50
· Addiction vs. Dependence (there is a difference) 17:15
· Brain Chemistry 20:00
· SSRI Mechanism of Action 21:30
· Bias…Keep it out of science 22:00
· Vaccines 24:50
· Side Effects of SSRI’s 26:00
· Withdrawal symptoms of SSRI’s 30:00
· No Name Calling 31:30
· More Keeping Politics out of science
Previous Podcast about Rescheduling and Legalizing Marijuana 32:00
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: Laughter: don’t take it too seriously.
Topics:
· Benefits of Laughter 02:00
· Ranting & Raving 06:00
· Leaf Blowers 07:45
· AI Recommendations 08:45
· Meditation – Mindfulness-Laughter 10:10
(Changing Your Chemistry)
· Short-term Benefits = stimulate heart, lungs & muscles 11:00
-
Increase endorphins
-
Relieve stress
· Long-term Benefits = improve immune system 11:30
- Decrease anxiety
· Negative Effects of Laughter 12:00
· Connect 14:00
· A Bag of Chemicals 14:30
· A Survival Tool 15:30
· “Don’t take it too seriously.” 17:30
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: This episode is about taking a toxin, isolating it, purifying it and then injecting it into your face; or other parts of your body. Safe use of botulism toxin A relies upon its local activity. The indications include cosmetic smoothing, excessive sweating, eye disorders, chronic migraines, and overactive bladder. Assessing the Benefit-Risk of Botox is also discussed, along with the need for close monitoring.
Topics:
· Botulism Toxin A 01:30
· Premarin 02:15
· Exotoxin & Endotoxin 03:00
· Biological Warfare 03:30
· Indications
-
Cosmetic
-
Severe Sweating
-
Cervical Dystonia
-
Blepharospasm
-
Strabismus
-
Chronic Migraine
-
Overactive Bladder
· History of Botox 05:50
· Mechanism of Action 06:20
· Benefit-Risk 08:30
· Local Effect 10:30
· Side Effect Rare 13:00
· Iatrogenic Bolulism
· Monitor – Journal 13:30
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: Journavx was born of the search for an option to opioids for moderate to severe pain relief. The early results are mixed, some claiming it to be a miracle drug, others dismayed with its lack of effectiveness and its side effects. Since Journavx utilizes a novel (non-opioid) approach to severe pain relief, the drug was fast-tracked by the FDA, which is a process used to facilitate the development and expedite the review of drugs which provide unmet medical needs, and thereby provide faster access for patients. Post marketing review is essential to fully defining this drug’s benefits and risks.
Topics:
· Opioid Crisis 01:00
· JOURNAVX – Moderate to Severe Acute Pain 01:30
· Mechanism of Action – New! 02:00
· FDA Fast Track – Novel Approach 03:30
· Acute Pain = 14 Dayn Approval 05:00
· Side Effects: Nausea, Constipation, Headache
Dizziness, Itching, Muscle Spasm. 05:30
· Further Studies Needed…07:00
· Precautions: Liver Function and Drug Interactions 08:00
· Dosing. 09:00
· New Approach Post Marketing Monitoring 11:00
· Shared Anecdotal Reports 11:30
· MedWatch – FDA 12:15
· Journaling 14:00
· Cause & Effect 14:30
· Follow-Up! 15:00
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: Panic attacks are real and more common than you might think. This is a discussion of the possible causes of panic attacks and when a panic attack becomes part of a panic disorder. Psychotherapy and medications, both first-line treatments, are considered here. The importance of compassion is essential: be kind to yourself and others.
Topics:
· Panic Attack Symptoms 02:15
· Panic Disorder 04:15
· Rule Out Medical Issues and Toxicities
· Incidence 07:30
· Causes? 09:00
· Compassion 10:15
· Psychotherapy 13:30
· Medications
-
Benzodiazepines – Xanax
-
SSRI = Zoloft/Paxil/Prozac
-
SNRI = Effexor
-
TCA = Imipramine
-
Beta-Blockers = Propranolol
· Monitor Treatments (Journal) – be patient 18:00
· Be Kind to Yourself and Others 18:50
· 988
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: This podcase provides a review of GLP-1 medications, from describing what they are, how and where the work in the body, and emerging new uses for this class of drug. The potential benefits of the GLP-1 drugs, coupled with their high cost, have spawned the compounding of these meds, raising legal and safety questions about this process. Even with the excitement of what these meds might provide, working with your physician and your healthcare team to ensure the safety and efficacy of the medications, and monitoring your treatment, is essential.
Topics:
Shared decision-making 01:00
Incretin Mimetics 01:40
Byetta 2005 03:00
Side Effects Become Indications 04:00
GLP = Weight Loss
Minoxidil = Hair Growth
Valproate = Mania tx
Sildenafil = ED
GLP-1 Kinetics 07:15
Hormones 09:30
Microdosing 12;00
GLP-1 Receptors 17:00
Exploring other GLP-1 Indications 18:15
GLP Anti-inflammatory Effects 23:30
More Research Needed to Provide Definitive Answers 24:00
NAFLD/Parkinsons/Alzheimers/Osteoarthritis/Chemical Dependency
Maintenance Med? 28:00
Monitor & Work with Healthcare Tea 28:00
Questions and comments to druggistforthepeople@gmail.com
Send us Fan Mail
Summary: An epidemic of Isolation and Loneliness? Recent studies have found this to be true, and the subsequent effects upon the mental and physical health of the isolated & lonely person are significant. They include an increased risk of dementia, heart disease, stroke, diabetes type II, obesity, depression and anxiety and the risks of the medications used to treat these ailments. These are potential physical and mental challenges for the person, in addition to the painful experience of isolation, wherein there is a lack of contact and support from others, and loneliness, wherein there is the subjective feeling of not having close meaningful relationships or a sense of belonging. We’ve all been there. The idea here is to think about helping yourself - and others - to connect
Topics:
· Surgeon General 2023 Epidemic of Isolation & Loneliness 02:00
· Isolation & Loneliness Defined
· Incidence of Loneliness by age 05:15
· “Say Hello in There” 06:10
· Existential Loneliness 09:00
· Health Risks of Isolation & Loneliness 11:00
Heart Disease 29%
Strokes 32%
Dementia 50%
Also increase incidence of Depression & Anxiety, Obesity, Diabetes Type II
· Risks & Causes of Isolation & Loneliness 14:00
· Technology (AI) 16:45
· Additional Meds d/t possible health risks of Loneliness/Isolation 22:45
· Drug for Loneliness? 23:15
· 988 Suicide and Crisis Lifeline 25:00
· Talk with Your MD 27:00
· If you are feeling alone, you are not alone in this
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: There are a lot of options in the supplements aisle, because there’s a lot of money in it. Supplements might contain vitamins, minerals, herbs, botanicals, amino acids (part of protein), enzymes and probiotics, as well as binding agents, preservatives, flavoring agents etc. The label claims for ingredients are required by the FDA to be “truthful and not misleading.” If a supplement label “supports” or “promotes” proper nerve function, or cellular energy, or metabolism, the claim is so nebulous or general that it might be impossible to prove that it was untruthful or misleading. What to do? We try to figure that out in this episode.
Topics:
· Supplements and $$$ 01:30
· FDA Approved Indication – Not 02:00
· Disclaimer 05:00
· 80,000 Supplements 08:30
· Claims: Health; Structure-Function; Nutrient 09:30
· Beware – Research – Communicate w/ Healthcare Team – Monitor
& Follow-up 12:00
-
FDA – Reports Problems/Benefits
-
Independent Labs = USP, Consumer Labs 22:00
-
Utilize and work with Healthcare Team. 23:00
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: The off-label use of naltrexone for chronic pain and inflammatory conditions is built upon observing patients being weaned from high dose naltrexone for alcohol abuse disorder, as well as its experimental use in boosting the immune system of HIV patients in the 1980s. Though the long-term use of LDN for chronic pain and the other inflammatory conditions has not been established, this unique mechanism of action may, in the future, provide another proven option for those in need. Or will it? We are in the process of discovery.
Topics:
· Low Dose Naltrexone Potential Uses 02:00
· Opioid Antagonists Naloxone and Naltrexone
· Receptor Interactions: Affinity/Intrinsic Activity/Dissociation. 04:15
· Naloxone & Naltrexone Chemistry
· Antabuse 08:20
· Fooling the Body – Negative Feeback Loop 11:30
· Microglial Cells Inhibition & Anti-inflammatory actions 12:50
· Applied Science of Medicine 14:00
· LDL Risks
· Quality of Life and Risk-Benefit 17:45
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: Rooting for your favorite team may very well influence your opinion of the referees in the game. Leave bias there. In healthcare, double-blind placebo-controlled trials and the metanalysis of studies are attempts to remove bias, so that objective reasoning can rule the day. JFK Jr. exhibited significant bias about vaccines prior to his confirmation as Secretary of Health and Human Services, and it has been evinced in his decision to stop the funding for mRNA vaccines. Blatant lies and unchecked bias threaten not only our healthcare options, but the very world in which they operate.
Topics:
· Bias 01:00
· Double Blind Placebo Controlled Studies 01:30
· RFK Jr 02:20
· Science is a Process 04:30
· mRNA 05:30
· Mutations 06:20
· Bacteria Too 07:45
· More Bias 10:00
· You Are The Experiment 12:00
· mRNA Risk Benefit 14:15
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: Slinging ugly, triggering words – like “psycho-emotional problems” - is an effort to awaken stigmas in the public against a person. Reject it. Mental Health, like our physical health, is an ever-changing dynamic. Though we expect mental and emotional health and stability in our leaders, the assessment of that issue should be objective and based on the best medical practice, and not on some sloppy reference intended to fan the flames of hate.
Topics:
· Psycho-Emotional Problems 01:00
· Unconrtrolled Fits 03:30
· Heavy Tranquilizers 04:30
· Stigma of Mental Health Challenges 05:00
· Public & Self Stigmas 07:00
· Intermittent Explosive Disorder (“Fits of Anger & Aggression”???) 09:30
· DSM-5
· Gelastic Seizures (“Fits of Cheerfulness”???) 10:40
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: This episode attempts to clarify how vaccines are made, how they are intended to interact with the immune system, and how important it is to obtain an unbiased source of information about the risks and benefits of a vaccine. Utilize your healthcare team.
Topics:
· Polio Vaccines 01:00
· Risk-Benefit 02:00
· Vaccines-Autism 03:00
· Modern Medicine 04:15
· Autism – DSM 06:00
· Immune System (learning what is you) 08:00
· Innate & Acquiered Immunity 11:00
· Chicken Pox Exposure and Shingrix 13:30
· Types of Vaccines 14:45
· Live Attenuated Vaccines 15:30
· Inactivated Vaccines 16:30
· Subunit Vaccines 17:30
· Toxoid Vaccines (Tetanus) 18:15
· Viral Vector
· mRNA 19:10
· BIAS – Remove it 23:30
· CDC Vaccine Risk – Benefit Site 24:50
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: When the president of the United States told his candidate for Secretary of Health and Human Services to “go wild” on health, food and medicines, I’ll bet he went and celebrated his pick with a McDonald’s cheeseburger and a Diet Coke. This podcast discusses the danger of placing politics and ideology into the healthcare system, the participants of which currently embrace the practice of Evidence-based medicine. This is the practice wherein the best available science is combined with the healthcare professional's clinical experience and the patient's values to arrive at the best medical decision for the patient. The idea is to eliminate bias. Let’s not go wild on that, in any part of the healthcare system.
Topics:
· What is “Again”? 01:00
· “Go wild” on health, food and medicines? 02:30
· Bias 03:20
· Exercise and Diet 06:15
· RFK Jr Confirmation Hearing 07:00
-
Nicotine Pouch?
-
Suggest SSRI’s as or more addictive than heroin
· Depedence Vs. Addiction 14:10
· RFK Jr. Actions as HHS Secretary 17:00
- April 11: cause of autism will be found be September
· Possible causes of autism 19:30
· RFK Jr. Actions as HHS Secretary
-
May 27: Change COVID Vaccine Recommendations
-
June 9: Remove Advisory Committee for Immunization Practices (ACIP) Members
· Evidence Based Medicine 24:30
· Levels of Scientific Evidence (not all are the same) 26:00
· JFK Jr. Swimming in Contaminated Stream 28:30
· No One Should Go Wild on HHS
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: I received a question about the possible therapeutic pharmacologic benefits of Nicotine, specifically the idea of cutting the Nicotine Patch for help with energy, autoimmune issues, and weight loss. Answering this question lead into a discussion of new drugs that may emerge from anecdotal evidence. In this case, how certain elements of Nicotine’s activity might lead to the development of new drugs with neuroprotective and anti-inflammatory effects, without the risks associated with Nicotine use.
Topics:
· Nicotine History 01:20
· Nicotine Patches, Side Effects 03:00
· Muscarinic & Nicotinic Receptors 06:00
· Alzheimers and Parkinson’s Disease in Smokers 08:00
· Reasoning Toward Possible Uses 09:00
· CNS & Immune Effects 09:45
· Rheumatoid Arthritis, Gout, Irritable Bowel Disease/ MS - reduce inflammation 11:00
· Journavx 11:30
· Long COVID 12:30
· Big Pharma Skepticism 15:00
· Consider the Source 15:50
· Use Your Pharmacist 17:20
· For All Drugs: Potential Benefit/Possible Risks Decide Positive Attitude MONITOR
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: Not all laxatives are created the same. Discussed in this episode are the nonpharmacologic options to relieve constipation, and the OTC Laxative options available should nonpharmacologic efforts fail. Included is a brief explanation of the peristaltic movement that is pooping, and how the different laxative options affect that process. Though there is often a silly poop joke or phrase lurking nearby i.e. dropping the kids off at the pool, a healthy and properly functioning bowel is essential for your overall health. Please consult your healthcare providers for any questions and guidance about constipation and your gut health.
Topics:
· Constipation Definition 02:00
· Before Using Laxatives 03:00
· OTC Laxatives 04:00
· Bulk Laxatives (Metamucil/Citrucel/Fibercon) 06:15
· Peristalsis and Bowel Movements 06:45
· Osmotic Laxatives (Miralax/MOM) 07:50
· Stool Softeners (Docusate) 09:30
· Lubricant Laxatives 10:00
· Stimulant Laxatives (Bisacodyl & Senna) 11:00
· Laxative Overuse 12:00
· Rx Laxatives
Irritable Bowel Syndrome with Constipation – Linzess 12:30
Opiate Use – Relistor to prevent GI effects of opiates 13:10
· Onset of Action 14:30
-
Bulk = 12 hrs to 3 days
-
Stool Softeners = 12 hrs to 3 days
-
Stimulant = 6 to12 hrs
-
Lubricant = 6 to 12 hrs
-
Enema/Suppository = 15 min to 1 hr
· Side Effects/Over usage 17:30
· Interactions with Medication Consult Pharmacist 19:25
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: The chemistry of your mind and body are almost always changed by the medications you take. But there is more to it than that. These changes are changing, in response to both your medications and in response to your thoughts, feelings, food, exercise, and sleep. About the medications, we focus on the benefit you might receive, and the possible risks associated with a potential drug therapy. And we keep track of it. This is always a good idea. But what about how you think and eat and sleep and move? Let's talk about it.
Topics:
· Pharmacokinetics & Pharmacodynamics 01:30
· Drugs “On board” 02:30
· Drugs & Your Chemistry 03:00
· Cookies & Your Chemistry 04:30
· Exercise, Sleep & Your Chemistry 05:00
· Diet, Thinking, Feeling & Your Chemistry 06:00
· Cortisol & Chronic Stress 06:30
· GABA Receptors (Benzodiazepines) 07:45
· Be nice? 08:40
· Meds & Risk-Benefit 09:00
· Hurricane Helene 09:15
· Premarin (pregnant horse urine) 12:15
· Depression…You Are Not Alone 14:15
· Depression Help Resources 15:15
Suicide & Crisis Lifeline = 988
Crisis Text Line = 741741
Outside of U.S = Befrienders Worldwide
· John Prine “Hello in There” 16:00
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: Preconceived notions within healthcare professionals about what another person might be, before we have a direct, open and genuine interaction with them, can derail the best treatment for that person. To provide the best treatment, efforts to effectively communicate continue by healthcare; but the person – the patient – must also make efforts to express themselves openly and honestly regarding their healthcare. Shared decision making: this episode is about getting in there, establishing an understanding of your options, and working WITH your healthcare team, including your pharmacist!
Topics:
· Shared Decision Making 01:15
· Generational Theory 02:00
· Culturally Competent Care 03:40
· Person Type = Another Bias 07:10
· Patient Perspective 12:00
· Medical Terminology = Bias 14:30
· Direct, Open & Genuine Talk with Healthcare 16:30
· Mary Berry 17:15
· LEARN (to facilitate shared decision making) 18:25
· Pharmacists – Team with them! 20:30
· Mayo Clinic 21:00
· Journaling 21:30
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: Why have bedbugs reemerged? What to do if bitten? And how to manage and prevent possible bedbug infestation.
Topics:
· Sleep Tight 01:30
· Bedbugs 02:00
· DDT 03:45
· Antihistamine, Topical Steroid Tx 06:15
· DDT & Auto-Immune Disease? 06:45
· DDT Risk Benefit (Africa) 08:15
· Prevention 09:00
· Permethrin 10:15
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: This episode recounts the experience of Hurricane Helene in North Carolina, from its arrival to the continued recovery. Being smart about what's fact or fiction, being there for your neighbors, and being prepared for a potential disaster (which we were not) are discussed here. Also discussed is a possible cure for the stress in this situation...go help someone.
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: What’s happening on the other side of the prescription counter? Probably more than you think. Safety and appropriateness of the drug regimen is an ongoing process, and it may slow down the speed with which you get your medication, but it’s essential in making sure the drug is safe and efficacious. The importance of being a good teammate in your own healthcare is what this, and all episodes, is aboutl.
Topics:
· Five Safety Checks 02:15
· Clinical Review by Pharmacist 04:00
· Best Treatment Evolving 06:45
· Provide Complete and Accurate Medication Profile 11:15
· Be a Good Teammate on Healthcare Team 12:00
· It’s For You 13:00
· Medication Counseling – Use It 13:254
· Journaling (determine Cause & Effect) 14:30
· Work WITH Your Healthcare Providers 15:00
Questions and comments to druggistforthepeople@gmail.com
Send us a text
Summary: Paying $75,000 dollars for a car because you want to have a back massage between home and work is one thing, but to face exorbitant costs because you want to live a healthy and longer life is a tough pill to swallow. Discussion of the risks and benefits of any medication with your healthcare provider is essential, and the costs of that therapy should be included in that conversation.
Topics:
· Most Common Med Indications 03:30
· Top 10 Most Prescribed Medications 04:00
· Most Common Meds by Cost 05:30
· Pharmacy Benefit Manager (PBM) 10:30
· Managing Cost 12:15
· Pharmacoeconomics 13:00
· Risk-Benefit
· GoodRx 14:00
Questions and comments to druggistforthepeople@gmail.com
Send us a Text Message.
Summary: neffy® nasal spray received fast track approval from the FDA on August 9, 2024 for the emergency treatment of type I allergic reactions, including anaphylaxis, in adult and pediatric patients who weight at least 66 pounds. This may be a gamechanger in that it provides emergency epinephrine treatment for anaphylaxis without needles. But, as with all medications, correct use and monitoring is necessary.
Topics
· Fast Track Approval 01:30
· $$$ 03:15
· Minimum Weight 66 pounds 04:15
· Approval Process 06:00
· Pharmacokinetics & Pharmacodynamics 07:00
· Epi Mechanism of Action 08:00
· How to use neffy 10:45
· Storage 13:00
· Gamechanger? 15:00
· risk – BENEFIT 16:20
· Dosing (1/2 Life) 18:25
· Storage 22:15
Questions and comments to druggistforthepeople@gmail.com
Send us a Text Message.
Summary: Previous podcasts (July 2023) have covered The Pill and the newly approved, progestin only, OTC oral contraceptive – the Opill. The Opill is on the shelves and available online now. This episode provides a brief overview. For more detailed information about the Opill, consider listening to the July 2023 podcast: Opill – the OTC Pill.
Topics:
· Opill-Antibiotics Interaction (Rifampin) 02:00
· How to Take 02:40
· Reminder July 2023 Podcasts: The Pill and The Opill 03:10
· Missed Doses 04:20
· Opill Drug Interactions 07:15
· Brief History of Oral Contraception 09:00
· Opill Contraindications 12:20
Questions and comments to druggistforthepeople@gmail.com
Send us a Text Message.
Summary: There are more ways to change your chemistry than taking drugs. Kindness. Being helpful, generous, and considerate – without expecting anything in return – has positive effects upon both the body and mind. But here’s the rub: you must be kind without expecting anything in return. So don’t be kind to be healthy…simply be kind. It’s all easier said than done. This episode also addresses the need for kindness in healthcare, from the healthcare professionals to the patient, and from the patient to the doctors, nurses, pharmacists, therapists – all who are trying to help.
Topics:
· Kindness Definition 01:15
· Body Benefits 01:30
· Mind Benefits 02:00
· Safe & Efficacious 06:00
· Trust 09:30
· Doctor-Patient Relationship 11:00
· Kickstart Kindness (Mayo Clinic) 13:00
Questions and comments to druggistforthepeople@gmail.com
Send us a Text Message.
Summary: Chemical and Physical Restraints are frightening terms, and yet the use of one or the other is sometimes necessary. This episode discusses the appropriate use of chemical restraints to treat agitation, as well as what may be the inappropriate use of medications to chemically restrain a person.
Topics:
· Agitation 02:00
· Danger to Self/Others 02:30
· AMA 02:50
· Respect the Person 05:45
· Informed Consent 10:15
· Detox (Klonopin/Librium/Ativan/Valium) 10:45
· Risperdal/Seroquel/Xyprexa 11:15
· Nonpharmacologic Interventions 12:30
· Rexulti 16:30
· Participate 18:45
Questions and comments to druggistforthepeople@gmail.com
Summary: To get the maximum benefit and minimize the risks of your meds, stay involved. Monitor, journal and communicate with your healthcare team to make sure your meds include only those that you actually need. Avoid the Prescription Cascade.
Topics: Polypharmacy 01:15
Prescription Cascade 0410
Therapeutic Duplication 06:00
Monitor, Journal & Communicate 07:15
Cause & Effect 07:50
Communicate Changes Between MD's 10:00
Max Benefit & Minimize Risk 11:30
Use Your Pharmacist 11:45
Questions and comments to druggistforthepeople@gmail.com
Summary: If it’s a hard pill to swallow, you’re not alone. In this episode we discuss why not to crush or break certain medications and possible techniques to help in overcoming pill dysphagia. As usual, consult your pharmacist.
Topics:
· Pill Dysphagia Definition 02:30
· Prevalence 04:30
· What Not to Crush and Why 05:40
· Drug Formulation Abbreviations 09:30
· Narrow Therapeutic Window 11:15
· Toprol XL, Sinemet CR – Exceptions 12:30
· Pill Dysphagia Techniques 13:00
· Applesauce 14:00
· Mayo Clinic 19:30
Questions and comments to druggistforthepeople@gmail.com
Summary: Just a little reminder about the negative (and positive) effects of Ultraviolet Radiation (both A & B), the options for managing those negative effects, and the drugs that may cause photosensitivity.
Topics:
· Out of Sight, Out of Mind 01:00
· UV Protection 01:30
· UBV & UVA Radiation 02:00
· Chemical Sunscreens 02:40
· Physical Sunscreens 03:20
· Broad Spectrum Protection 04:00
· Apply Liberally & Often 04:40
· Children 05:30
· UV Radiation, Cholesterol & Vitamin D 06:30
· Photosensitivity Drugs 07:30
· Nothing on Skin but Shade? 08:00
Questions and comments to druggistforthepeople@gmail.com
Summary: SPF and Broad Spectrum Protection From UV Rays – A more detailed discussion of protecting your skin from the damaging effects of UVA and UVB radiation.
Topics
· Chemical &Physical Sunscreens 02:00
· UVB & UBA 03:00
· Skin Types 04:00
· Ozone 05:00
· EPA – Atmosphere Warnings 05:20
· Broad Spectrum Protection 07:45
· Physical = Blocker; Chemical = Absorber 09:30
· UV Radiation and Vitamin D 10:40
· Photosensitivity by Drugs 11:50
· Apply Liberally & Often 13:25
· Sprays 14:00
· Babys and Children 17:00
· Sensitive Skin = Physical 18:00
· Chemical Sunscreen Absorption? 18:30
· Bug Repellant & Sunscreen? 19:15
Questions and comments to druggistforthepeople@gmail.com
Summary: This episode discusses what makes a generic drug equivalent to a brand name drug, according to the FDA, and why some variability is okay - and unavoidable.
Also discussed is the importance of monitoring your response to the generic medication, use of Pill Identifiers, participating in the FDA Medwatch program, and utilizing your pharmacist for questions about generic substitutes, including the excipients that may be different from one manufacturer to another.
Topics:
· Changing Generic Companies 02:30
· Sertraline (Zoloft) 04:00
· Drug & Quantity Same 04:30
· Excipients Different 05:10
· Bioequivalence 05:30
· Pharmacokinetics 06:00
(Rate of absorption, Total Drug absorbed)
· Variance 07:00
· Statistics 08:00
· Confidence Interval 08:30
· Variance and Probability 12:30
· Monitor You! 13:45
· Pill Identifier 14:00
· MedWatch – FDA 14:40
· Excipients 16:00
Questions and comments to druggistforthepeople@gmail.com
Summary: If you’re watching your TV, we’re seeing what you see: Drug Ads. In this episode, we take a look at Vraylar as an add-on to your current antidepressant. So bottom line, what is it, this Vraylar?
Topics:
· To Begin With: 00:45
988 is the Suicide and Crisis Hotline, offering 24/7 call, text and chat access to trained crisis counselors who can help people experiencing suicidal, substance use, and/or mental health crisis, or any other kind of emotional distress
1-800-FDA-1088 or visit www.fda.gov/medwatch to report negative side effects of drugs to the FDA
· Commercials 03:00
· “Stuck…Lift” 04:15
· Vraylar Mechanism of Action 04:30
· Second Generation Antipsychotic 05:15
· Indications 06:10
· Add-On to Antidepressant for Major Depression 07:45
(with Prozac/Paxil/Zoloft…Effexor/Cymbalta…Wellbutrin)
· Maximizing Benefits and Managing Risks 09:30
· Monitor & Participate 12:15
· Side Effects & Adverse Drug Reactions 12:30
· Benefits 14:15
· Drug-Drug Interactions 17:15
(includes all meds and supplements)
· Utilize Your Pharmacist 19:00
· Journal 20:30
· Right Drug at the Right Dose – for You 21:30
Questions and comments to druggistforthepeople@gmail.com
Summary: The Proton Pump Inhibitors (PPI’s), which include Prilosec, Prevacid, Protonix, Aciphex, and Nexium, are a very effective group of drugs to treat heartburn and reflux, but as with every other drug, there might be side effects and adverse effects, both short and long-term. In this episode, we discuss the possible link between the long-term use of PPI’s and dementia, as reported in the press and medical journals.
Topics:
· Proton Pump Inhibitors (PPI’s) 01:30
· H2 Blockers (Tagamet, Pepcid) 02:00
· Prevacid, Prilosec, Protonix, Nexium, Aciphex… 03:40
· Cause & Correlation 05:10
· Depression & Dementia (Correlation) 07:20
· How PPI’s Might Cause Dementia (MOA) 08:30
· Neurofibrillary Tangles and Amyloid Plaque 09:00
· Blood-Brain Barrier 09:45
· PPI’s & Decreased Vitamin B12 Absorption 11:00
· Benzo’s & PPI’s (Diazepam & Omeprazole) 12:00
· Participate in Care (Talk With Your Pharmacist) 13:30
· Medication Reconciliation 19:15
· Got a Question – Ask Your Doctor/Pharmacist 20:00
· Conflicting Study Results = We Don’t Know! 20:25
· Risk-Benefit 22:30
Questions and comments to druggistforthepeople@gmail.com
Summary: If you have poison ivy, can you spread it to someone else? If the poison ivy is dead, can you still have a reaction if you touch it? Where else can you get poison ivy, besides touching the plant? This episode addresses these questions, and in so doing, touches on the prevention and treatment of the contact dermatitis caused by poison ivy, poison oak, and poison sumac.
Topics:
· Urushiol Oil 01:50
· Contact Dermatitis 02:15
· Spread? 02:55
· Dogs/Cats/Clothes/Tools 04:30
· Inflammation 06:45
· Prevention 07:45
· Antihistamines 09:25
· Wash Clothes 10:00
· Topical Hydrocortisone 11:25
· Topical Anesthetic 13:25
· MD – Rx Treatment 15:00
· Prednisone Oral 15:25
· ID Poison Ivy, Oak, Sumac 16:15
· Use Your Pharmacist!
Questions and comments to druggistforthepeople@gmail.com
Summary: When the panic attack comes from what’s inside, where do you hide? It’s thought that a panic attack is physiologically very much like a flight or fright response, comparable to encountering a Grizzly bear on a trail. In this episode we discuss the current medications available for treating panic attacks and panic disorder and how these medications work. We also discuss other non-medication options such as psychotherapy (talk therapy), exercise, yoga, and acupuncture.
Options:
· Panic Attack 01:45
· Fight or Flight Response 02:15
· Quality of Life 03:25
· Panic 04:25
· Symptoms 05:00
· Risks for Panic Attacks 06:45
· Complications of Panic Attacks 08:00
· Prevention 08:00
· Treatments
· Prozac/Paxil – SSRI’s 09:30
· Effexor XR – SNRI 09:55
· Risk-Benefit 11:45
· Xanax/Klonopin – Benzo’s 12:45
· Risk-Benefit 14:30
· Journaling 15:00
· Use Your Pharmacist! 15:45
· Non-Med Option – Psychotherapy 16:15
· Cognitive Behavioral Therapy 17:00
· Participate! 17:35
· Carol’s Mom – Help Someone 23:50
Questions and comments to druggistforthepeople@gmail.com
Summary: Blood clot formation and breakdown happens all the time. It’s when the body potentially forms clots where they aren’t needed (AFib) that we run into problems: strokes and heart attacks. In this episode we make the distinction between antiplatelet drugs and anticoagulants and their roles in preventing unwanted clots. How they work? Once again, we’re just tinkering with a natural process in our bodies.
Topics:
· Balance of Clot Formation and Breakdown 02:15
· Tissue Plasminogen Factor 02:45
· Blood Thinner = Antiplatelet & Anticoagulant 03:40
· Side Effects = Bleeding 05:30
· Monitor! 08:00
· GI Bleed 11:00
· Blood Pressure 12:15
· Journaling 13:00
· Plavix, Brilinta, Effient, Aggrenox 14:40
· Warfarin – Rat Poison? 15:45
· Acute Coronary Syndrome 19:45
NSTEMI/STEMI/Unstable Angina
· Reversal of Anticoagulants 22:30
· Direct Oral Anticoagulant (Pradaxa,Xarelto,Eliquis) 24:15
· Duration of Treatment 25:15
· Participate 26:00
Questions and comments to druggistforthepeople@gmail.com
Summary: The drug ads float images of happy people across the room, with a voiceover discussing the mechanism of actions of the drug (JAK inhibitor) along with an undercurrent of warnings and side effects of the drug. One of the newer drug groups are these JAK inhibitors, an oral form of targeted immunotherapy. This episode attempts to explain this drug group, and also discusses to whom exactly the drug companies are directing their ads.
Topics:
· Drug Ads 01:20
· Opzelura 02:00
· Targeted Immunotherapy 02:45
· Monoclonal Antibodies (MABs) 03:15
· JAK Inhibitors – small molecules 03:45
· Risk-Benefit Discussion 14:30
· Black Box Warnings 15:30
· Monitor and Journal 19:00
· Participate!
Questions and comments to druggistforthepeople@gmail.com
Summary: This episode introduces a phrase uttered thousands of times every day regarding medications: anticholinergic side effects. A brief discussion follows about how and why these side effects may occur, what these side effects are, the drugs that may cause them, and the importance of discussing these possible side effects with your pharmacist and physician. Having a side effect of a medication is not unusual, but it shouldn’t it be unusual for you to understand the benefits of your medication and at the same time manage the side effects, by working with your doctor and pharmacist.
Topics:
· Acetylcholine 01:35
· Central Effects 02:30
· Peripheral Effects 03:00
(muscle and autonomic nervous system)
· Alzheimer’s Treatment 03:45
· Aricept, Exelon, Razadyne 04:00
· Side Effect due to too much acetylcholine = cholinergic 04:30
· Side Effects due to blocked acetylcholine – anticholinergic 05:30
· Peripheral Autonomic Side Effects of anticholinergics 06:30
· Central Side Effects of anticholinergics 07:45
· Beer’s List 08:00
· Side Effect or Symptom? 08:45
· Drugs causing Anticholinergic Side Effects 09:00
· Journal-Communicate 10:20
· When to accept Side Effects, Risk-Benefit 11:30
· Work with your healthcare team 12:00
Questions and comments to druggistforthepeople@gmail.com
Summary: Marijuana is currently considered by the government to have the same abuse and dependency potential as heroin (Schedule 1), and yet 27 states have legalized marijuana either for medicinal and/or recreational use. This makes no sense. This episode addresses this disconnect and delves into the issues created by a few U.S. Senators who want to deschedule and legalize marijuana. Legalizing marijuana may address the changing attitudes toward marijuana and its place in society, but de-scheduling it fails to make a distinction between marijuana’s use as a recreational drug and its use as a medication. This episode seeks a solution to this issue.
Topics:
· Elizabeth Warren, Stephen Colbert 01:00
· Scheduled Drugs I-V 01:50
· Schedule I Drugs 02:15
No medical use; high abuse/addiction potential
Marijuana, Heroin, LSD, Ecstasy, Peyote…
· Deschedule Marijuana? 03:45
· Alcohol a drug? 04:00
· Prohibition 04:50
· Marijuana a drug?...a medication? 05:45
· Cannabis Sativa = plant 06:20
Cannabinoids = compounds in plant
· Solution? 07:00
· Legalize the plant, Reschedule the compounds 08:00
· Pot Potency 09:00
· Department of Health & Human Services – Schedule III 11:05
· Marijuana Drug Interactions 12:45
· Epidiolex, Marinol, Cesamet 13:40
· Kinetics, Dosage, ADR, Drug Interactions…14:30
· Risk-Benefit 16:00
· Gateway Drug? 16:30
· Plant & Compounds 18:00
· More Potential Medical Uses 18:30
· Ch-Ch-Change
Questions and comments to druggistforthepeople@gmail.com
Summary: The complex dynamics of sexual dysfunction is beyond the scope of this episode, but what we can discuss is the effect that drugs, both prescription and OTC, can have on causing sexual dysfunction (in this podcast, primarily ED in men). The importance of education and clear communication between a patient and their healthcare team is essential, to determine if the sexual dysfunction may be due to a side effect of a medication or is it a symptom of some other physiologic or psychological cause. Moving forward, using your physician to address these problems may result in fine-tuning your current medications, and this may also avoid possible drug-drug interactions with medications to treat ED.
Topics:
· Excitement, plateau, orgasm, resolution 02:00
· Erectile Dysfunction (ED), non-drug causes 03:30
· ED, Drug Causes 05:10
· Side Effect or Symptom (anti-depressants & depression) 05:30
· Anti-depressant Options 06:40
(Bupropion, Remeron, Trintellix, Viibryd)
· Viagra, Cialis 07:30
· Anti-psychotics 08:30
· Mood Stabilizers (Lithium, Carbamazepine) 09:30
· Noncompliance 10:00
· Benzodiazepines 10:40
· OTC Drugs (Benadryl, Pepcid, Zantac…) 11:30
· Journaling-Communicating 11:45
· Blood Pressure Meds 14:15
(diuretics, alpha blockers – Hytrin, Minipress, beta blockers)
· Viagra, Cialis Drug Interactions 16:30
· ED & CHF 17:40
· Priapism 19:20
· Supplements 20:30
· Women & Sexual Dysfunction 21:40
· Addyi 22:30
· Vyleesi 23:00
· Non-drug Options 24:30
· Cause and Effect (figure it out!) 25:00
Questions and comments to druggistforthepeople@gmail.com
Summary: Knowing when a “symptom” is actually a side effect can save you a lot of trouble. By participating, by providing your physician and pharmacist an accurate accounting of when medications were started - and when possible side effects occurred – any changes to your medications will be based on a more accurate picture. It’s a process. And it can be complicated, but the accurate and timely sharing of your observations, whether they be signs, symptoms or side effects, is how you can work with your physician to provide the best treatment for you.
Topics:
· Side Effects, Symptoms, Signs Definitions 01:30
· Risk-Benefit? 05:30
· CHF & Beta Blockers 07:00
· Confirming Cause & Effect – Statins 08:30
· INSOMNIA 11:00
(primary, secondary, onset, maintenance, mixed)
· INSOMNIA Secondary Causes 12:30
· Worry 15:00
(meditation, cognitive behavioral therapy…)
· Your Pharmacist (research possible SEs) 18:00
· INSOMNIA Primary Causes 19:15
(Depression, anxiety, hyperthyroid, sleep apnea
Restless leg syndrome, Alzheimers…)
· ??? Symptom or Side Effect??? 21:00
- JOURNAL. JOURNAL. JOURNAL.
· Medwatch FDA 23:00
· Adverse Drug Reaction 23:30
Questions and comments to druggistforthepeople@gmail.com
Summary: I think people trust that if a product is displayed in nice bright packaging beneath the bright white lights of the gas station, that it must be okay, it must be meeting some king of standard. Not necessarily. This episode addresses two types of “gas station drugs”: gas station heroin and ED pills. Those pills may well have gotten to those shelves and the FDA had no idea about it. Since there is a disclaimer stating the FDA has not evaluated any claims and that the product is not intended to treat, cure or prevent any disease, most people think the worst that can happen is nothing. This episode is about not taking that chance.
Topics:
· Gas Station Trust 01:30
· No Doz 02:15
· Dietary Supplement Health Education Act (DSHEA) 1944 03:00
· Supplement Explodes on market 03:30
· FDA does not approve supplements; Reacts to problems 04:00
· Gas Station Heroin 05:00
· Tianeptine 05:30
Zaza/Tianna Red/Neptune’s Fix
· Gas Station Heroin Claims 06:20
(improved brain function/treat anxiety & depression/pain relief…)
· Opioid withdrawal Symptoms 06:45
· Other ingredients? 08:00
· Problem = Products are not reviewed for safety or effectiveness 10:00
· Erectile Dysfunction (ED) Pills 11:00
· Rhino 11:45
· What’s in the pill? 12:50
· Possible Side Effects 14:30
· Board of Pharmacy Notification16:00
· Utilize Pharmacist 17:00
· Reference = Natural Products (Facts & Comparisons) 18:00
· Since FDA doesn’t review, see if your pharmacist can 19:00
Questions and comments to druggistforthepeople@gmail.com
Summary: The big pharmaceutical companies have always had a choice: whether to place their focus on the patient or on profits. Every pharmaceutical company (Eli Lilly has determined that they are a “medicine company’) will attempt to present as being there for the people, and they will have a business plan that is about profits and the “health” of the company. But Big Pharma is not in the clothing or automobile business…they are in the “health of the people” business. So why develop a drug that – due to its price – may be out of reach for the average patient in need? Profits for the drug company are expected, but to what extent, and at what cost?
Topics:
· Name it to Hate it 01:30
· Public Distrust in Big Pharma 03:00
($$$, Concealing Facts about Safety, Patents)
· Research & Development/Rx Sales 04:15
· Humira – a monoclonal antibody 06:40
· New Drug Application & Patent 07:00
· More Patents and More Money 08:20
· Biosimilar Options Prevented 09:00
· Enbrel 09:45
· Meds for the People 10:30
· Bernie Sanders – HELP Committee 11:15
· Drug Advertising 12:15
· Vioxx 13:55
· Purdue Pharma – Oxycontin 14:40
· Free Lunches 16:50
· Big Pharma Lobbyists 18:00
· 1800 Lobbyists for 535 Members of Congress 20:00
· Be a Lobbyist for You! 20:30
· In the Meantime – Pharmacoeconomics 21:20
· Monitor – Journal – Communicate 22:45
· Know what we Don’t Know 22:20
· Greed is Real 26:40
· Participate 27:40
Questions and comments to druggistforthepeople@gmail.com
Summary: The discussion of medication errors continues here, with a focus on the opportunities to prevent medication errors. Not all prescription medications are created equal. Regarding medication errors, this means that the potential adverse events that might occur, with an error, are more severe with high-risk medications. Are you on a high-risk med? Once again, a person who is familiar with their drugs, and motivated to participate in their own care, with their healthcare team, is essential to medication management, including preventing medication errors. And finally, a reminder: you are not on an island. Work with your healthcare team, including your pharmacist.
Topics:
· The 5 Rights of Medication Administration 01:30
· Pill Identifier 02:45
· Risk Factors 09:00
· Patient Education 10:30
· Indication? 11:15
· Intended Outcome? 11:30
· Adverse Events (possible) 11:40
· High Risk Medications 12:30
· Blood Thinners 13:30
· Minimize Distractions 14:45
· Drugs in Drug Errors 16:10
Insulins/Albuterol/Morphine/Potassium Chloride
Heparin/Levofloxacin/Cephalexin/Furosemide
Vancomycin
· Medication Adverse Events in ER Visits 19:00
And Hospitalizations
· Monitor Drugs with High Risk of Toxicity 21:00
(Warfarin, Insulins, Digoxin…)
· Medication Reconciliation 21:30
· Journal and Team Approach 23:10
· “Human Proof”? 23:30
Questions and comments to druggistforthepeople@gmail.com
Summary: The goal is always to have zero medication errors, and yet they occur. This episode takes a look at what is considered a medication error (missed doses count), how often medication errors occur, how often they cause harm to the patient (who is actually a person), and the importance of a team-approach (pharmacists, physicians, nurses, patients, and anyone who is part of the person's healthcare) to preventing medication errors.
Topics:
· Medication Errors – Commission & Omission 04:30
· Med Error Prevention: Team Approach 04:45
· Flexeril Dose 06:45
· Beers Criteria Medication List 07:00
· Medication Errors -> Drug Related Problems 08:00
· ER Visits due to Medication Events (14%) 09:15
(32% of these due to noncompliance)
· Hospital Discharge Meds Knowledge
(28% of patients could list discharge meds;
Fewer could state intended use of medications.
· Journaling 13:15
· Frequency of Medication Use 14:10
· Polypharmacy 15:30
· Medication Error Incidence & Harm 16:50
· Medication Error Incidence of Death 19:00
Questions and comments to druggistforthepeople@gmail.com
Summary: To be more involved in your healthcare - your medications in particular - and to be able to participate in a conversation with your pharmacist or doctor, you might need to become your own detective. And to that end, this episode briefly reviews the different drug classes in order to help you to realize the “whys” of your drug regimen, and in turn to more actively participate in your care, with your healthcare team.
Topics:
· Allergic Reaction – Chemical Class 03:30
· Sulfa and Sulfur – the Difference 04:20
· Therapeutic Class = Indication = What it’s for 05:20
· Same Druggists 06:10
· Mechanism of Action – Digging Deeper 06:50
· Multiple Mechanisms of Action 08:25
· Therapeutic Duplication 10:45
· Only One Chainsaw 11:20
· Controlled Substances 11:45
· Get in the Conversation! 13:15
· Be Your Own Detective 14:00
Questions and comments to druggistforthepeople@gmail.com
Summary: The relatively recent release of Ingrezza and Austedo (2017) offer an option for the treatment of the abnormal involuntary movements associated with Huntington’s Disease and Tardive Dyskinesia (TD), a condition associated with the use of neuroleptics. This episode addresses the multiple activities of dopamine, how neuroleptics work by blocking dopamine receptors, and how this may result in TD. In turn, the presumed activity of Ingrezza and Austedo are discussed, potentially easing the distressing symptoms of TD.
Topics:
· Involutary Movement 01:20
· AIMS 02:00
· Tardive Dyskinesia TD 02:30
· Risk-Benefit 04:00
· Dopamine 04:20
· Dopamine Receptor Blocking Agents (neuroleptics) 06:00
· Risk of TD (Haldol, Prolixin, Reglan…) 07:40
· Ingrezza & Austedo for TD 10:00
· Dopamine & Acetylcholine Balance 11:30
· Dopamine Effects 13:10
· Dopamine Neurotransmitter 15:20
· Ingrezza & Austedo Mechanism of Action 18:00
· TD Symptom Relief 19:00
· Ingrezza & Austedo Dosing, Side Effects, Precautions… 20:00
· Drug-Drug Interactions 27:00
Questions and comments to druggistforthepeople@gmail.com
Summary: Any job is made easier – or possible – by having the right tool for the job. The same goes for getting the most benefit out of your drug(s) and minimizing the risks of your medication. The right tool for this is at your fingertips…actually, it includes your fingertips: it’s you, being a drug detective.
Topics:
· The Right Tool 01:00
· Get in the Game 01:55
· Evidence Based Medicine 02:25
· Patient Values 03:00
· Utilize Your Pharmacist 03:45
· Drug Detective – Journal 04:35
· Deep Dive 05:50
Questions and comments to druggistforthepeople@gmail.com
Summary: This episode looks at the relatively widespread use of Trazodone for insomnia, an off-label drug use of this antidepressant. Currently, there is some disagreement in the medical community on Trazodone’s place in the treatment of insomnia, but that does not necessarily make its use wrong or inappropriate. While that discussion goes on, what can you do about it’s off-label use now? Listen.
Topics:
· Twenty Rx FDA Approved Meds for Insomnia 02:30
· Trazodone not a DEA Controlled Substance 03:00
· Benzodiazepine Use History 03:30
· 1987-1996 Trazodone Use Up, Benzo Use Down 04:00
· Why Trazodone? 05:00
· Evidence Based Medicine 05:30
· Quality of Evidence 06:15
· What Can You Do? 09:30
· Risk-Benefit 11:00
· Drug Journal 11:15
· Participate 11:30
Questions and comments to druggistforthepeople@gmail.com
Summary: A listener shares his experience with the treatment of his Prostate Cancer, from the initial diagnosis, research into the best treatment for himself, his strict adherence to this treatment, and his continuing follow-up as he is now seven years cancer-free. This discussion attempts to clarify some of the terminology encountered in this listener’s journey.
Topics:
· Treatment Options 01:50
· Wait and Watch
· Surgery
· Hormone Therapy
· Radiation Therapy
· Immunotherapy
· Do Research – Support Groups 04:00
· Questions When Told You Have Prostate Cancer 05:00
· Signs & Symptoms same as BPH 07:00
· Questions When Deciding on Treatment Plan 08:00
· Biopsy 10:00
· Anti-androgen 11:00
· Radiation (Brachytherapy) 11:20
· Quality of Life 16:50
· Attitude? 17:30
· Gleason Score 18:00
· Talk to People – MD, Support Group 20:00
· Follow-up With MD
· Resource: American Cancer Society 22:40
Questions and comments to druggistforthepeople@gmail.com
Summary: Sometimes when you start a medication, you first might have to adjust to the idea of taking a drug every day, and then to the reality of its effects upon your body and mind. But this episode is about another step that you might want to add to this scene: monitoring and then communicating with your healthcare provider. When was the last time your doctor called to see how you were feeling? It’s you who has to start this communication, and with this interaction, you might just find the drugs being adjusted to you.
Topics:
· Shared Decision Making 01:50
· Staying In the Game 02:10
· Supplements and OTC’s 02:45
· Adjusting the Drug to You 03:00
· Dosage? 05:15
· ACE Inhibitors to ARB’s 06:10
· Clarifying Options 06:45
· Clinical Parameters 08:20
· Reporting Side Effects 09:15
· It’s About You 10:10
· Lithium Carbonate & Table Salt 10:40
· Fine Tune Your Drugs to You 12:15
Questions and comments to druggistforthepeople@gmail.com
Summary: The balance of the flora in the gut is essential to maintaining a healthy barrier between what’s in your GI tract and what’s in your bloodstream. This episode addresses how broad-spectrum antibiotics can cause C. Diff, the dramatic effects of this and how it is treated. Also discussed is how diet, alcohol and some drugs may affect the balance and diversity of the microbiome in your, thereby causing Leaky Gut (allowing contents of gut into the body), which in turn may cause or aggravate a variety of conditions, from autoimmune disorders to diabetes to Alzheimer’s.
Topics:
· Gut-Brain Connection 01:30
· Finding the Mother Tree 03:00
· Antibiotics & C. Diff 04:40
· C. Diff Treatment with Drugs 06:15
· C. Diff Treatment with Fecal Transplant 07:50
· Prebiotics 08:45
· Antibiotic Stewardship 09:25
· Leaky Gut 09:50
· Leaky Gut Causes – Diet & Alcohol 15:10
· Leaky Gut Causes – Laxatives, Proton Pump Inhibitors, NSAIDS, Statins? 17:90
· Gut Serotonin Production 21:30
· Journal & Participate 23:30
· Conditions Caused by Leaky Gut 26:00
· Heart Disease?
· Autoimmune Diseases
· Alzheimer’s
· Dietician & Nutritionist Resources 30:00
· Diet & Med-Gut Connections – Pay Attention & Participate 32:40
Questions and comments to druggistforthepeople@gmail.com
Summary: Headlines are meant to grab your attention, whether it’s about politics or sports or medicine. And so it goes for Semaglutide (Ozempic and Wegovy) and Liraglutide (Victoza and Saxenda), whose attributes have been trumpeted for weight loss, and whose possible serious side effects have recently been noted in the press. This episode attempts to take some of the sensationalism out of the headlines and advertisements by examining Relative Risk and what it means for your actual and Absolute Risk.
Topics:
· Incretins 03:20
· Gliptins 04:30
· Ozempic Headlines 05:10
· Absolute & Relative Risk 05:45
· Lighting Strike Risk 06:30
· Risk-Benefit 09:00
· Convert to Absolute Risk 10:30
· Pancreatitis, Stomach Paralysis, Bowel Obstruction 11:00
· Relative Risk to Absolute Risk 16:25
· What We Don’t Know 19:30
· Monitor & Participate 20:30
· Post-Marketing Monitoring/Medwatch 21:00
Questions and comments to druggistforthepeople@gmail.com
Summary: Like it’s never happened before, the FDA approval of a new weight loss drug grabbed the headlines, but here’s another headline: Same Stuff, Different Packaging – Zepbound. This episode is a review of this very effective and very popular group of new drugs: the Ozempic-like drugs, the Incretin Mimetics, which act like the gut hormones secreted in response to food. The idea here is to provide a broader perspective on this group of drugs, so you might understand what is happening now, and perhaps you will not be surprised by what may happen in the future. Whether it's coincidence or a subtle nod to Zepbound's intended use, it will be available shortly after Thanksgiving.
Topics:
· Diabetes – Weight Loss 03:00
· Hormones 04:00
· Incretins 04:30
· New Drugs in Same Class 08:00
· Zepbound Mechanisms of Action 10:50
· Zepbound Side Effects 12:00
· Zepbound Indications – BMI 13:30
· Zepbound Effective? Yes 14:30
· Semaglutide: Ozempic-Wegovy 16:30
Liraglutide: Victoza – Saxenda
Terzepatide: Mounjaro – Zepbound
· With Exercise & Diet 18:30
· Rybelsus (Semaglutide) - Oral 19:30
· Document-Monitor-Participate 20:00
· Post-Marketing Monitoring – MedWatch (FDA) 20:45
Questions and comments to druggistforthepeople@gmail.com
Summary: Do Echinacea, Vitamin C and Zinc have a place in the prevention and treatment of viral infections such as the common cold or the flu? What should be a straightforward discussion about risks and benefits is complicated by the lack of regulation by the FDA, and therefore the uncertain content of some herbal supplements.
Topics:
· Cold, Flu and COVID-19 02:30
· Virus-Living or Not? 03:20
· Echinacea 06:45
· Echinacea History 07:50
· Echinacea Quality of Products 09:00
· Germany 10:40
· Talk With Your Doctor
· Contraindication with Echinacea 12:50
· Risk-Benefit 14:45
· Side Effects 16:00
· Caffeine-Echinacea Interaction 18:25
· Vitamin C 19:00
· Zinc 22:00
· Zinc Nasal Spray – Potential Permanent Loss of Smell 26:00
· Participate – Use Your Healthcare Team 28:00
Questions and comments to druggistforthepeople@gmail.com
Summary: For decades the FDA told us phenylephrine worked, that it was safe and effective, and now we hear that it is safe, but maybe not so effective? This episode addresses the oral phenylephrine situation specifically, including possible options for when/if oral phenylephrine is pulled from the shelves. We also take a look at the FDA process for establishing the status of drugs, and where concerned citizens are able to participate in this process.
Topics:
· Decongestant Pharmacology 01:45
· Oral Phenylephrine 02:00
· Phenylephrine vs. a Skittle 03:20
· GRASE 03:40
· Phenylephrine 10mg Dose 06:00
· Sympathomimetic 07:30
· FDA Advisory Committee 08:50
· Citizen Petitions to FDA 10:10
· Pharmacology 10:45
· Options to Oral Phenylephrine 12:00
· Development of New Options? 16:30
· FDA Ruling Process 19:00
· Placebo Effect 21:00
· Participate-Monitor 23:00
Questions and comments to druggistforthepeople@gmail.com
Summary: I’ve forgotten how to sleep. Try harder? No. Trying to sleep is like trying to forget something: the more you try the more you lie awake, remembering what you are trying to forget. The treasured good-night’s sleep evades so many of us, so here is a brief discussion of a relatively new group of drugs for insomnia, with a reminder to consider utilizing cognitive behavior therapy to help you on your sleepy way.
Topics:
· Nonpharmacologic Stuff 01:55
· Cognitive Behavior Therapy 02:00
· Sleep Hygiene 02:15
· Belsomra, Dayvigo, Quviviq 03:15
· Stop the Waking Up 04:00
· Orexin Receptor Antagonists 04:20
· Quviviq 05:00
· Hypnotics 05:55
· Start Low 06:30
· Sleep & Drug Journal 06:40
· Transient, Short-term and Long Term Insomnia 06:55
· Risk-Benefit 07:30
· Warning: Worsening of Depression &/or Suicidal Ideation 08:45
· Narcolepsy – No. 09:15
· Monitor and Participate 11:05
· FDA Approved – Post Marketing Data 12:00
Questions and comments to druggistforthepeople@gmail.com
Summary: The rising number of children and teens suffering with mental health issues, primarily anxiety and depression, is not a blip, but rather a real trend. Anxiety or depression has grown by thirty percent in children aged 3 to 17, between 2016 and 2020. The Covid-19 pandemic certainly had an effect, but prior to Covid-19 mental health disorders in children and teens was already on the rise. According to Health and Human Services, between 2009 and 2019 high school students who reported persistent feeling of sadness or hopelessness increased by forty percent. The “People” in this episode is a Pediatrician, who shares his experiences with mental health issues in children and teens, discussing where we were, where we are and why, and perhaps where we might go in the future. This is Part 2 of a 2-part series.
Topics:
· Risk-Benefit, Monitor, Participate 02:00
· SSRI’s 02:30
· Monitor Closely 05:00
· Double Blind, Randomized, Placebo Controlled 05:15
· Meds and Attitude 06:00
· Anxiety, ADHD, Depression 09:50
· Neurotransmitters 10:30
· Work With the Doctor 16:00
· Resources: 988 & Mobile Crisis (Google) 18:00
· Emergency Room for Psych Evaluation 18:30
· Communication 19:40
Questions and comments to druggistforthepeople@gmail.com
Summary: The rising number of children and teens suffering with mental health issues, primarily anxiety and depression, is not a blip, but rather a real trend. Per a Health and Human Services Study, anxiety or depression has grown by thirty percent in children aged 3 to 17, between 2016 and 2020. The Covid-19 pandemic certainly had an effect, but prior to Covid-19 mental health disorders in children and teens was already on the rise. According to Health and Human Services, between 2009 and 2019 high school students who reported persistent feeling of sadness or hopelessness increased by forty percent. The “People” in this episode is a Pediatrician, who shares his experiences with mental health issues in children and teens, discussing where we were, where we are and why, and perhaps where we might go in the future. This is Part 1 of a 2-part series.
Topics:
· Mental Health Trends in Children 02:00
· Emo 04:00
· Anxiety and Depression 04:45
· American Academy of Pediatrics & U.S. Surgeon General 05:00
· U.S. Government Response 05:30
· Cognitive Behavioral Therapy & Meds 07:20
· Social Media 08:10
· Family Unit Affected 13:10
· Parents 14:45
· Solutions? 15:40
· Suggestions for Parents 17:00
Questions and comments to druggistforthepeople@gmail.com
Summary: A new option is coming for an often-underreported condition: postpartum depression. The FDA Fast Tracked the review of Zurzuvae, thereby acknowledging that this new drug may fill an unmet medical need. We discuss how this drug works, how quickly it can have an effect, and (as usual) the importance of actively participating in the risk-benefit discussion and subsequent monitoring with your healthcare professional.
Topics:
· Fast-Tracked 01:05
· Incidence of Postpartum Depression 06:00
· Postpartum Depression 07:10
· Previous Drug Options 08:00
· Zulresso IV 08:30
· Cost/Insurance? 09:00
· Causes of Depression 09:30
· Zurzuvae Mechanism of Action 10:30
· Neuroactive Steroid 11:00
· Zurzuvae Dosing 12:00
· How Soon to See Effect 12:30
· Zurzuvae for Major Depression? 13:45
· Side Effects 14:30
· 988 15:15
· Breastfeeding 15:30
· Risk-Benefit 15:45
· Phases of Clinical Research 17:00
· Phase 4 of Clinical Research – Post Marketing 18:00
· Drug Journaling 18:45
· Drug-Drug Interactions 19:45
· Monitor and Participate 24:45
Questions and comments to druggistforthepeople@gmail.com
Summary: Another option for treating anxiety might be laying in the bottom of your toolbox, resting beneath the handful of drug options – Xanax, Buspirone, Escitalopram, Sertraline, Propranolol… It’s Meditation. This episode looks at a comparison of the effectiveness of Escitalopram (an SSRI) versus Mindfulness Meditation for the treatment of anxiety, and though the results are impressive, this does not serve as a recommendation, but rather an indication that another possible option might be there for you. As always, work with your healthcare team to determine the best course of treatment for you. Participate in your healthcare - Monitor - Participate...
Topics:
· Another Tool for Anxiety 01:40
· Drugs for Anxiety (benzo’s, buspirone, beta-blockers, Escitalopram) 02:05
· How does Lexapro work? 03:30
· Anxiety and Depression 04:30
· Escitalopram 05:00
· Risk-Benefit 06:00
· Shared Decision Making 06:15
· Buspirone 07:35
· Chemistry of Anxiety 07:50
· Participate-Monitor-Participate 08:45
· Just Trying Stuff 09:20
· Escitalopram Vs. Mindfulness-based Stress Reduction (Medication) 10:45
· The Right Tool for You 11:50
· Thirty Percent Reduction in Anxiety Symptoms 13:00
· Escitalopram Side Effects 13:50
· Meditation Side Effects 14:10
· Is Meditation a Harder Pill to Swallow? 18:00
· Resource: Mayo Clinic 22:00
· Why Not Med & Meditation? 22:15
· Choose the Right Tool for You 23:00
Questions and comments to druggistforthepeople@gmail.com
Summary: This episode is in response to a listener’s question about the Rx sleep-aid Lunesta, and the discussion includes the close relatives Ambien and Sonata, which share the same mechanism of action. Like every other drug, the risks-benefits of this group of meds should be discussed with your doctor prior to use, and the discussion should continue as you monitor your sleep patterns and use of Lunesta.
Topics:
· Non-Med Options 02:30
· Sleep Hygiene 03:15
· Risk-Benefit of Lunesta 04:35
· Ambien 05:15
· Mechanism of Action of Lunesta 05:50
· GABA Receptor Stimulation 06:30
· Benzodiazepines 07:30
· Sonata – Ambien – Lunesta 08:10
· Designed for Short-Term Use 08:45
· Follow-up: Talk with MD 09:00
· Possible Side Effects 09:45
· Drug Diary 11:15
· Drug-Drug Interactions of Lunesta (362) 12:00
· Ask Your Pharmacist About Drug, Nutrients, Supplement Interactions 12:50
· Cause and Effect – Solving Problems 14:30
· Non-Med Treatments 15:00
· C-IV…Do Not Stop Abruptly; Contact MD 15:30
· When and How to Administer 16:30
· Dosing 17:25
· Addiction, Tolerance and Dependencem18:20
Questions and comments to druggistforthepeople@gmail.com
Summary: Why an antipsychotic drug for depression? This powerful group of drugs – the atypical neuroleptics -- and specifically Abilify, represent a useful tool in the treatment of Bipolar Depression. A thorough review of precautions and possible side effects, a risk-benefit discussion with your physician, along with continued monitoring, drug journaling and utilizing your pharmacist are all important to ensuring the safe and effective use of this drug-tool.
Topics:
· Abilify (aripiprazole) = Atypical Antipsychotic/Neuroleptic 03:30
· Autism Spectrum, Tourette’s Syndrome, Bipolar I Disorder 04:20
· Exact Mechanism of Action of Antipsychotics? 05:00
· Metabolic Syndrome 06:20
· Journaling 08:05
· Low Risk of Metabolic Syndrome with Abilify 09:05
· Side Effects Comparison 10:10
· Risk-Benefit Discussion 12:50
· Precautions 14:00
· Getting in the Game 15:30
· Drug Journaling! 16:40
· Using the Tool Correctly 18:15
· Talking About It 20:00
Questions and comments to druggistforthepeople@gmail.com
Summary: Lots of drugs have moved from prescription to OTC status: proton pump inhibitors (Prilosec), Histamine 2 blockers (Prevacid), antihistamine eye drops, Hydrocortisone 1% cream…. For this to happen, the question that must be answered is this: can the drug be used safely and effectively, relying only on the drug labeling? The above-mentioned drugs have passed this test. This episode will discuss another switch, the first OTC oral contraceptive: Opill.
Topics
· Monitor Your Meds 03:40
· Progestin Only 04:20
· Reduce Barriers to Access 05:00
· Relying on Drug Labeling 06:10
· Progestin = Norgestrel (1973) 07:15
· Same Time Every Day 07:40
· Precautions 09:00
· Looking Out For You (Drug Diary) 10:00
· Talk With Your Pharmacist 10:10
· Side Effects 10:30
· Progestin Only Advantages 11:15
· Age Restriction? 13:00
· Release early 2024 14:00
· Does Not Prevent Sexually Transmitted Diseases 14:25
· Concerns – Talk With Pharmacist & Doctor
Questions and comments to druggistforthepeople@gmail.com
Summary: Off-label drug use rings of risk, of a doctor gone rogue, of an unknowing patient in danger. But this issue - using drugs approved for one indication for a completely different use - is more common than you would think, and the reasons for this are simple and sensible. This is a look at how an FDA-approved drug may launch in a trajectory for an intended indication, but may find itself in a different orbit: off-label drugs.
Topics:
· Off Label Drug Use (OLDU) 02:00
· Approved Indications 02:45
· Benefit Outweighs Risk 03:25
· Monitoring Drug Usage: Discovering New Uses 04:25
· FDA – Does NOT regulate practice of medicine 05:00
· No Advertising for OLDU 05:45
· Psych/Peds/Pregnant Women OLDU 06:45
· Physician Disclosure 07:00
· Mood Stabilizers (carbamazepine, valproate) 08:25
· Psych/Peds/Pregnant Women 09:10
· Why Not New Approval? 10:25
· Tricyclic Antidepressants (amitriptyline, Imipramine) OLDU 11:45
· Life Threatening Conditions 13:00
· Methotrexate 14:00
· Lantus Insulin 16:30
· Evidence that is accepted w/in profession of medicine 17:25
· Baclofen and Hiccups 18:00
· Hydroxychloroquine 19:00
· Orphan Drugs 20:10
· Emergency Use Authorization 21:25
· Gabapentin 22:15
· Monitor-Monitor-Monitor 22:30
Questions and comments to druggistforthepeople@gmail.com
Summary: Your bones, like everything else in your body, are part of a dynamic system: in this case calcium is stored or released, depending on the needs of your body and the amount of calcium consumed. Bone mineral density, which measures calcium and other minerals, provides a picture of the strength of your bones. Naturally – or maybe not so naturally – when there is a low bone mineral density (osteopenia or osteoporosis) there are drugs designed to affect this building and breakdown of bone. This episode discusses alendronate – a common drug in the bisphosphonate class, designed to slow bone resorption (breakdown).
Topics:
· Osteopenia Definition 01:15
· Osteoporosis Definition 01:50
· t-number 02:10
· Bone Remodeling 04:25
· Bone = Calcium reservoir and source 04:50
· -penia 06:40
· Before Meds 07:20
· Drug-Induced Osteopenia 08:00
· You’re Not Alone! 09:45
· Osteoclasts and Osteoblasts 11:00
· Bisphosphonate – Alendronate 11:50
· GI Concerns 14:20
· Duration of Treatment? 14:45
· Alendronate Onset of Action 15:20
· Evista 16:00
· Alendronate Possible Side Effects 18:25
· Jaw Necrosis (rare) 21:00
· Resources 23:00
· Falls Prevention 23:15
· Monitor You 24:30
· Pharmacist and Physician 24:50
Questions and comments to druggistforthepeople@gmail.com
Summary: Though “the Pill” is ubiquitous with oral contraceptives, it refers to many different combinations, dosages, and packaging of the hormones contained therein: forms of Estrogen and Progesterone. This episode looks at the history of The Pill, at the actions of the pill within the body of the woman, and at the actions of the pill within the body of the community. And finally, at the continuing importance of every woman considering the risks and benefits of the pill as it applies to her.
Topics:
· Progestin 02:05
· Pill History 02:45
· Comstock Law 03:00
· Cycle Control…Contraception = Side Effect 03:25
· Pill and Society 03:55
· Pill and Cigarettes 04:45
· Male Birth Control 06:30
· Effectiveness 08:25
· NuvaRing Insert 08:50
· Nexplanon Implant 09:05
· How It Works 09:30
· Drug-Drug Interactions 13:00
· When to Start & Missed Doses 14:15
· Risk-Benefit Discussion 14:30
· Communicate 16:50
· Monitor 18:30
· Extra Protection 19:10
· Respect Each Woman’s Decision 21:20
· Pill’s Action Within Body of Woman and Within Body of Community 21:40
· Eliminate Bias - Objective Article Review 22:00
Questions and comments to druggistforthepeople@gmail.com
Summary: This episode is about what I didn’t know about: when and how do we put our dog to sleep? Discussed here is the difficult decision-making process, the drugs used the day of the event, and the peace that comes with being thankful for the time we had together and that we have done the right thing in the right way.
Topics:
· Decision-Making Process 02:55
· Tylenol PM – NO 03:30
· Celebrating Bam Gobbles 04:00
· Respect and Reverence 04:30
· Sedative = Telazol IM 04:45
· Pentobarbital IV 06:00
Questions and comments to druggistforthepeople@gmail.com
Summary: The instant-to-instant changes that occur in you, be they responses to a change in the weather, seeing beauty where you had forever missed it, or worries that just won’t go away, all might result in changes to your chemistry, to the balance that is a healthy you. Generally, pharmacy is about chemistry, specifically in the form of a drug, that is added to your body, to try and establish a healthier chemical balance in you. But this episode addresses the private pharmacy that exists in each of us, put into action by our thoughts, or by the situation we might find ourselves in. Specifically, we will consider Chronic Stress and your private pharmacy, and why reducing chronic stress is good for what ails you.
Topics:
· Acute and Chronic Stress 02:00
· Adrenalin and Cortisol 02:30
· Cortisol = Hydrocortisone 04:30
· Body Systems effected by Chronic Stress 04:45
· Hormone or Drug? 05:30
· Symptoms of Chronic Stress 06:45
· Managing Your Private Pharmacy 08:55
· Fear of Missing Out (FOMO) 10:10
· Thoughts Into Chemistry 10:40
· Caregivers and Chronic Stress 11:45
· Chronic Stress Relief 12:30
Questions and comments to druggistforthepeople@gmail.com
Summary: Mood Stabilizers seems like too casual a term for this group of drugs…what could go wrong starting a mood stabilizer? Plenty. Mood Stabilizers might suggest to a person that they just take it when they need it, when the fact is these meds require regularly-scheduled dosing. How about we refer to this class of drugs as Neurodown-regulators, or maybe Neuronal-firing reducers? It’s what they do. This episode will touch on the role of mood stabilizers in the treatment of bipolar disorder, the importance of a person’s attitude and behavior regarding these meds, as well as possible side effects of these drugs. As always, a medication log is recommended for the person, as well as communicating routinely with their healthcare professional about concerns, attitudes, and behaviors.
Topics:
· Mood or Moog? 01:25
· Bipolar Disorder 01:45
· Apply or Comply? 03:00
· NonAdherence 04:25
· Lithium, Carbamazepine, Lamotrigine, Valproate 05:30
· Patient-Person 06:20
· Monitor 06:54
· Therapeutic Levels 07:22
· Lithium Carbonate 07:30
· Lithium Toxicity 08:05
· Anticonvulsants = Carbamazepine, Lamotrigine, Valproate 09:15
· Adherence 10:30
· Lithium Possible Side Effects 11:55
· Lithium Toxicities 14:40
· Don’t Take It When You Need It, Take It Because You Need It 16:45
· Drug Log (Cause and Effect) 17:00
· Valproate (Valproic Acid) Possible Side Effects 19:15
· Monitor, Monitor, then Monitor 20:15
· Carbamazepine Possible Side Effects 20:20
· Lamotrigine (Lamictal) Possible Side Effects 21:40
· Stevens Johnson Syndrome 21:50
· Drug-Drug Interactions 23:00
Questions and comments to druggistforthepeople@gmail.com
Summary: Prescription drugs are so often approved for what they can do for you, and abused for where they can take you…and so it goes for Ketamine. Valued for its ability to provide sedation and analgesia while maintaining cardiorespiratory stability, its abuse lies in its dissociative and hallucinogenic actions. This episode is a brief discussion of the history of ketamine, what it is, how it might work in the brain, possible new indications as a prescription medication, and possible adverse effects of long-term ketamine abuse. Recent studies indicate these troubling long-term effects may include memory impairment and diminished executive functioning i.e. ability to plan ahead and meet goals, display self-control and stay focused despite distraction.
Topics:
· Dissociation 01:40
· K – Hole 02:10
· Dissociative Anesthetic Hallucinogen 03:00
· Spravato (eskatamine) 03:55
· Altered States 04:45
· Hallucinations – Drugs to Prevent & Drugs to Induce 05:15
· Balance 06:00
· Chronic Pain Management, Neuropathy, Migraine, Refractory Depression 06:30
· Response Time to Meds for Depression 07:00
· Ketamine Mechanism of Action? 09:30
· A Spiritual Experience? 11:20
· Ketamine Side Effects 12:40
· Close Monitoring 17:00
Questions and comments to druggistforthepeople@gmail.com
Summary: The medical term is vasomotor symptoms (VMS); the more common term is hot flashes and night sweats; the term used by my wife is Sweaty Betty. And that’s as nice as she can be about it. Recently the FDA issued a Priority Review for Veozah, due to its unique non-hormonal action and if approved, the potential significant improvements it might provide for moderate to severe hot flashes, compared to standard applications. This May it was approved. In this episode we introduce Veozah as a new option in the treatment of hot flashes, this discussion as always including the Risk-Benefit analysis of the drug.
Topics:
· Veozah 01:21
· FDA Priority Review 01:43
· Risk-Benefit 02:13
· VMS (Vasomotor Symptoms) 03:55
· Hypothalamus 05:27
· Thermoregulatory Dysfunction 05:41
· Biofeedback 05:57
· Hormonal Therapy (Estrogen/Progesterone) 06:39
· Non-Hormonal Therapy 07:29
(antidepressants, gabapentin, pregabalin, oxybutynin, clonidine and Veozah)
· Mind-Body Options 08:15
· Veozah Mechanism of Action 09:25
· Randomized, Placebo-Controlled, Double Blind Study 10:00
· Placebo Effect 10:41
· Risk-Benefit Analysis 12:20
· Risk-Benefit Analysis of Veozah 13:10
· Veozah Possible Side Effects 14:10
· Veozah Drug-Drug Interactions 15:40
· Post Marketing Data 16:30
· Monitor-Monitor-Monitor 17:15
· Veozah Cost 18:00
Questions and comments to druggistforthepeople@gmail.com
Summary: To discover how you got here, you must care enough to ask the question. This episode is not about peeling away the layers to discover what’s at the mysterious center of your med regimen; rather, it's simply about starting with the drugs which address your most urgent health needs – in this case, your heart. We will follow that trail of drugs (one often leads to another), and then move on to other medical conditions i.e., comorbidities. Ultimately, achieving a balance of the right drugs, doses, and schedules, by monitoring your meds and communicating with your physician and pharmacist, will not only reveal how you got here, but it may result in a better here.
Topics:
· Meds For Life 01:55
· Vioxx & Celebrex 02:24
· Vioxx Voluntary Pull 04:00
· Celebrex 05:07
· Acute Coronary Syndrome 06:12
· Plavix (post first stent) 06:36
· Nitroglycerin 06:56
· Brilinta 07:15
· Metoprolol Tartrate 07:50
· Nitro-Dur Patch 10:09
· Nitro Headache 12:00
· Nitro-Viagra/Cialis Interaction 13:15
· Monitor Your Meds 14:30
· Atorvastatin & Fenofibrate 16:35
· Lopid 18:32
· Brilinta & Aspirin 19:00
· CoQ10 20:55
· Tamsulosin (Flomax) 22:12
· OTC Drug Interactions 22:30
· Vitamin D 24:10
· Shared Decision Making 25:09
Questions and comments to druggistforthepeople@gmail.com
Summary: Time to talk about the number one prescribed drug in the United States. Xanax? Ozempic? Adderall? Nope. Atorvastatin (Lipitor)! You fasten your seatbelt to prevent possible harm, and people do the same with the statins, the possible harm being a stroke or heart attack. It’s all about oil in water. It’s all about cholesterol and triglycerides (fats) in your blood (92% water). Why you have cholesterol in your blood, and why you might start, why you might continue, and why you might possibly have to stop Statins. And should they fall short in lowering your cholesterol, or you cannot tolerate them, the options are discussed as well.
Topics:
· What are Statins? 01:30
· Oil in Water 02:12
· Atorvastatin (Lipitor) 02:55
· Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin 03:30
· Starting Statins due to Risk Factors 04:35
· Low Density Lipoproteins (LDL) 05:35
· Stabilize and Prevent 06:00
· High Density Lipoproteins (HDL) 06:25
· Cell Membranes & Hormones 07:00
· Diet & Exercise Statins 07:20
· Statin Side Effects 07:55
· Liver Function 08:00
· Type 2 Diabetes 08:37
· Muscle Pain 09:33
· Nocebo Effect 10:20
· Crestor 11:23
· Memory Loss? 12:00
· Right Statin at Right Dose at Right Time 14:08
· Statins and Grapefruit 14:35
· Maintenance Med 16:00
· Commit and Monitor Your Therapy 16:35
· Statin Alternatives 16:55
· Repatha & Praluent (monoclonal antibodies) 17:05
· Familial Hypercholesterolemia 17:58
· Leqvio 18:36
· Nexletol 19:03
· Zetia 19:15
· Cost Risk 19:40
· Colestipol 20:39
Questions and comments to druggistforthepeople@gmail.com
Summary: Why Sertraline for me? Why any drug for you? Research and development of new drugs doesn’t travel in a straight line. If luck is where preparation meets opportunity, there’s plenty of luck on that winding trail in the pharmaceutical industry. This episode traces the development of antidepressants, including new emerging possibilities, ultimately answering a listener’s question: why sertraline for me?
Topics:
· Gone Fishing 01:05
· Why Sertraline for me? 02:00
· MAO Inhibitors (Nardil) 02:27
· Tri-Cyclic Antidepressants 03:30
· Serotonin Specific Reuptake Inhibitors (SSRI’s) 04:25
(Prozac, Celexa, Zoloft)
· Serotonin & Norepinephrine Reuptake Inhibitors (SNRI’s) 05:25
(Cymbalta, Effexor, Pristiq)
· Wellbutrin (bupropion) 06:00
· Ketamine 06:36
· Comorbidities 07:36
· Sexual Dysfunction 08:30
· Trazodone 08:54
· Risk-Benefit & Algorithms 09:38
· Talk to and with your MD! 11:00
· When started? Dose? Intended Effects and Adverse Effects 12:10
· Cause and Effect 12:50
· Help @ 988 and SAMHSA 1-800-662-4357 13:14
Questions and comments to druggistforthepeople@gmail.com
Summary: Alcohol for alcohol addiction? Nope. Opioids for opioid addiction? Yep. Why? And for how long? The addiction to opioids digs in deep and doesn’t want to let go. Discussed here, to better understand treatment for opioid addiction, is a brief history of how we got here, the principles of how opioids work in the body, and how the opioids for treatment are supposed to work. Also discussed is the opioid addict’s lifeline: naloxone.
Topics:
· Pain Management 01:41
· Oxycodone-Morphine Comparison 04:10
· Heroin 05:07
· Compassion, Respect and Opioids 05:51
· Alcohol 06:29
· Naltrexone 06:36
· Antabuse 06:50
· Opioids for Opioid Addiction 07:31
· How Do It Work? 07:54
· Opioid Receptors, Endorphins and Dopamine 08:10
· Receptor Affinity 09:00
· Intrinsic Activity 09:10
· Dissociation 09:20
· Opiates = Naturally Occurring 11:47
· Opioids = Natural, Semi-synthetic and Synthetic 11:58
· Methadone Treatment 13:10
· Methadone Clinics – the Treatment Dose 16:00
· Suboxone 17:31
· Suboxone Ceiling Effect 18:31
· Suboxone Maintenance or Withdrawal? 21:30
· Chasing the Impossible 23:07
· Heroin -> Opiate Receptor -> Endorphin Release -> Dopamine Release 23:30
· Tolerance, Dependence and Addiction 23:52
· Naloxone 26:05
· Naloxone Nasal Spray OTC 30:00
· Reach Out For Help 30:11
988 Suicide and Crisis Lifeline
SAMHSA National Helpline = 1-800-662-HELP (4357)
Local Hospital ED...
Questions and comments to druggistforthepeople@gmail.com
Summary: A little understanding of the culprit drugs can go a long way in preventing them from becoming gang members and doing harm by causing a fall. There are usually several factors that contribute to a fall, from a difficult-to-navigate environment (extrinsic cause) to the things going on inside your mind and body (intrinsic cause), including your condition and the effects of drugs. Here, we hope to change the question from ‘why did he fall?’ to ‘how do we prevent him falling?’
Topics:
· Where Most Falls Occur 02:31
· Intrinsic Causes 02:50
· Extrinsic Causes 03:00
· Culprit Drugs 03:31
· Culprit Drug Actions 04:20
· Toileting 05:27
· Culprit Drug Groups 06:20
(neuroleptics, antidepressants, antiepileptics, antiparkinson, narcotic analgesics, sedatives-benzodiazepines, diuretics, antiarrhythmics, vasodilators, cholinesterase inhibitors)
· Starting a Med and Monitoring 07:45
· Polypharmacy 10:03
· Example Drug Regimen 12:10
· Lasix 12:45
· Neurontin (Gabapentin) 13:36
· Nitroglycerin 14:10
· Percocet (oxycodone & acetaminophen) 14:30
· Zoloft (sertraline) 14:52
· Metoprolol – a Beta Blocker 15:04
· Orthostatic Hypotension 15:42
· Interventions 16:00
· Education 16:23
· Lower Doses? 16:31
· Work With Doc for Dosage Adjustments, Med Changes17:11
· High Risk Meds 17:23
· Safer Therapeutic Options 18:18
· Benzodiazepines 18:28
· Talk With Doc 18:58
· The Environment – Outside and Inside You 20:17
· Resource: CDC Website STEADI 20:53
· Understanding the Culprit Drug 22:15
Questions and comments to druggistforthepeople@gmail.com
Summary: Hundreds of OTC products, with nuanced combinations of medications, presented with bold colors and appealing claims, cloud what could be a clear picture of which product would be best for you. In this podcast, we address the oral over-the-counter options for pain, one ingredient at a time, for indications such as fever, pain, inflammation, and hang-overs. In the search for OTC pain meds at the grocery or drug store, the question of trade name versus generics presents another question. Are they the same?
Topics:
· Acetaminophen vs NSAIDS 01:45
· Acetaminophen – Centrlal/Brain 03:33
· NSAIDS – Peripheral/Body 04:12
· Children 07:00
· Sprains and Strains 08:40
· Naproxen 09:20
· Hangovers 10:40
· Vasopressin 11:10
· Generic vs. Trade Name 14:00
· New Drug Application 14:34
· Narrow Therapeutic Index 16:48
· Phenytoin, Digoxin, Anticonvulsants 17:05
· Orphan Drugs 18:36
· Research 19:31
Questions and comments to druggistforthepeople@gmail.com
Summary: Who - or what - does just what it’s supposed to do? That’s got to be a small club. Actively participating in the management of your meds by having an idea of the intended effect, the incidence of possible side effects, and then following up with your pharmacist and doctor goes a long way to dealing with a drug’s unintended effects. Figuring out golf, on the other hand, is like trying to lasso a cloud. This episode explains why some side effects occur and how they can be managed, while at the same time acknowledging that some side effects are just wacky.
Topics:
· Intended Effects 01:15
· Lisinopril 01:48
· Dry Cough 02:22
· Golf Intended Effects 03:05
· Golf Unintended Effects 03:21
· Extension of Pharmacologic Effects 03:42
· Amlodipine Face Flushing 04:25
· Calcium Channel Blockers 04:57
· Amlodipine Mechanism of Action – Intended Effect 05:33
· Amlodipine Mechanism of Action – Unintended Effect 05:50
· Wacky Side Effects 06:15
· Incidence of Side Effects 07:15
· Doc Talk 09:10
· Resource: Mayo Clinic Site 09:15
· Risk-Benefit Discussion 10:40
· Tracking Meds from the Start 11:15
· Use the Pharmacist! 12:30
Questions and comments to druggistforthepeople@gmail.com
Summary: Pharmacists are instructed on how to talk with people about their medications: communicate verbally, communicate non-verbally, establish trust, listen, ask questions, show empathy and encouragement, remain clinically objective…. But where are the instructions for the patient on how to talk about their medications with the pharmacist or the doctor? That is what this podcast is about.
Topics:
· Laws Mandating Pharmacist Counseling 02:06
· Being an Active Participant 04:24
· Shared Decision Making 05:33
· The Right Drug Question 06:32
· Risk-Benefit of Not Taking the Meds 07:10
· Monetary Risk 07:40
· Best Medical Evidence 08:26
· Treatment Algorithm 08:48
· Urgency? 09:32
· Is the Risk-Benefit Changing 10:15
· Quality of Life 10:46
· New Drugs on the Treatment Algorithm 12:51
· Shared Decision Making – Step Up! 14:06
Questions and comments to druggistforthepeople@gmail.com
Summary: The thinking that “it’s just a supplement” can lead to some serious problems, possibly due to the actual activity of the supplement and/or possibly due to interactions with other supplements and medications. So it's important to have some respect for the possible effects of the supplement, but that said, the claims made on the bottle of the supplement must be followed by the following: “This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.” So where does that leave you? This episode attempts to provide the big picture of how supplements are regulated and monitored, and also to provide some direction about how to safely use supplements.
Topics:
· Dietary Supplement Health & Education Act 02:00
· Supplement Claims 02:45
· Supplement Disclaimer 02:52
· Side Effects 03:23
· Starting a Supplement 04:28
· Respect the Supplement 05:20
· St. John’s Wort 05:34
· Double-Blind, Randomized, Placebo-Controlled Studies 06:58
· Bias 07:21
· Resources 09:45
· Aspirin & the Willow Tree 10:08
· Premarin & Pregnant Mare Urine 10:12
· Digoxin & Digitalis 11:14
· Respect the Supplement! 12:07
· A Good Diet or a Supplement Pill? 12:47
· United States Pharmacopeia 13:17
· FDA Post-Marketing 14:00
· Echinacea 14:30
· Collagen and Proteins 15:50
· Collagen and Chicken 17:29
· Resources 18:31
· Natural/Organic? 19:30
Questions and comments to druggistforthepeople@gmail.com
Summary: Most of the world doesn’t work this way: drug companies splashing their products across your television screen with catchy jingles and bright color combinations that, hard as you try, you can’t forget. The drug companies wouldn’t keep advertising this way if it wasn’t working. But it hasn’t always been this way. This episode takes a closer look at prescription drug advertising in the United States, with the focus on the person who will make the informed and shared drug decision with the doctor – you.
Topics:
· FDA 1983 Rule Change 01:27
· Harry and Megan and the Brits 02:01
· Mad Men (inform, persuade, remind) 02:22
· New Zealand and the USA 02:55
· Proton Pump Inhibitors 04:05
· Discovering Side Effects 04:54
· Death Side Effect 06:15
· Discovering Options 07:20
· 80 Drug Ads Per Hour 08:55
· JAK Inhibitors 10:15
· Continuing Education 11:40
· Shared Decision Making 13:01
· Pet Parasite 14:20
· Drug-Drug Interactions 15:14
· This Life with This Drug! 16:40
Questions and comments to druggistforthepeople@gmail.com
Summary: Why give an amphetamine to someone who can’t sit still? And why has there been a shortage of Adderall? And what happens when someone drinks with Adderall? This episode addresses these questions, beginning at the molecular level with how these drugs have their effect, to why on the societal scale there has been an increase in the usage of Adderall. And finally, what happens when Adderall is taken with alcohol, and why this is a bad idea. In addition, the discussion also addresses the positive effect of these drugs for those in need, and the effect of these drugs in those who misuse them, and who thus confirm its proper classification as a substance with a high abuse potential.
Topics:
· Amphetamine to Hyperactive Person? 01:56
· Mechanism of Action 02:14
· Ritalin (methylphenidate) 02:55
· Dopamine, Norepinephrine, Serotonin 03:25
· Neurochemical Balance 03:56
· Long Term Use 04:50
· Receptor Sensitivity 05:30
· Blood Pressure 05:50
· Narcolepsy 06:15
· Misuse (weight loss/study/party drug) 06:20
· ADHD vs. non-ADHD 07:05
· Function vs. Fly (indication vs. abuse) 07:54
· Alcohol and Adderall 09:42
· Adderall Shortage 13:15
· DEA Pandemic Policy Change 14:09
· Drug-Disease Interactions 15:48
· Adderall Stories – Anxiety/Drowsiness/Feeling 16:15
· Non-Stimulant ADHD Options (clonidine, guanfacine, atomoxetine) 19:22
· ADD or DAD? 21:10
· Abuse Potential and Balance 22:10
· Drug-Drug Interactions 23:50
Questions and comments to druggistforthepeople@gmail.com
Summary: This episode is in response to a listener’s question about his expired Epi-Pen: how long is it still good to use? The potential life-saving action of the Epi-Pen puts it into the must-have-on-hand medication group, but the price and waste can be a financial and frustrating stressor. What is stability, and why are these expiration dates assigned? Drug shortages and the high cost of medications may be changing how the stability dates of specific medications are assigned. Get caught up on expiration dates.
Topics:
· Epi-Pen 01:52
· FDA 03:05
· Stability = Strength, Quality and Purity 03:51
· Why these dates? 04:08
· Bottom Line – Don’t Take It 05:10
· Drug Shortage Shelf Life Extension Act 06:05
· Push To Conserve Meds 07:16
· FDA Drug Shortage Task Force 2019 08:05
· Shelf Life Extension Program (SLEP) 08:50
· Controlled Environment and Unopened Containers 10:58
· Epi-Pen 11:25
· Nitroglycerin 15:19
· Albuterol, Eye Meds…15:35
· Mottled, Crumbling Tablet 16:50
· Keep Up With Exp. Dates 17:50
· Prescription Bottle – Lot Number 17:58
· Disposal of Expired Meds 19:19
Questions and comments to druggistforthepeople@gmail.com
Summary: Ozempic usage recently skyrocketed due in part to high-profile people using it for the off-label use of weight loss, and due in part to social media picking up on this. Is this the magic injection people have been looking for to lose weight? The positive actions of this drug, which mimics a hormone, are discussed along with some of the possible adverse reactions. In the course of this discussion, the idea of this being a “magic medication” revolves around who is using it and why. A brief look at the off-label use of other drugs is discussed, revealing the on-going need for Risk-Benefit analysis and continued monitoring of both on and off-label therapy, by both the patient and the healthcare professional.
Topics:
· Social Media 1:07
· Ozempic Primary Endpoint – A1C 01:27
· Ozempic Secondary Endpoint – Weight Loss 01:54
· Ozempic Mechanism of Action 02:12
· Pancreatitis, Hypoglycemia, Thyroid 05:10
· Wegovy 05:30
· Zenical 05:48
· Top of the Food Chain Problems 07:25
· Risk of “Magic Medication” 09:05
· Cardiovascular Benefits of Ozempic 09:32
· Shortage 09:45
· Ozempic Summary of Actions 10:45
· GI Distress – Side Effect and Mechanism of Action? 12:31
· Risk-Benefit of Prescription Drugs 13:09
· Off-Label Use 14:12
· Minoxidil 14:27
· Sildenafil (Viagra) 14:45
· Valproate 15:15
· Baclofen 16:11
· Broad Range of Ozempic Actions 16:45
· Rakes Instead of Blowers 18:06
· Hydroxychloroquine 18:33
· Risk-Benefit! 19:15
Questions and comments to druggistforthepeople@gmail.com
Summary: It’s happening, almost always happening - drug interactions. But is the drug-drug interaction significant? And is it intended, using the primary mechanism of action or side effects of one drug along with another drug’s effects to achieve the desired result? Or is it a potential problem, the risks and benefits assessed, with monitoring in place, to guide the management of the drug-drug interaction? What the body does to the drugs and what the drugs do to the body is where these drug-drug and drug-nutrient interactions occur. This episode provides an overview of this, with the idea being to better understand and more effectively communicate with your physician and pharmacist about these issues.
Topics Covered:
· Drug Interactions 03:50
· Pharmacokinetics - Absorption 04:58
· Tetracycline Absorption Interactions 05:15
· Sucralfate 06:08
· Metoclopromide 07:07
· Dangerous Drug-Drug Interactions 08:20
· Intended Drug-Drug Interactions 09:02
· Probability, Severity and Management 09:45
· Precautions 10:00
· Contraindications 10:20
· Xarelto and Heparin 11:00
· Pharmacokinetics – Distribution 11:35
· Protein Binding 12:15
· Phenytoin and Diazepam 12:30
· Pharmacokinetics – Elimination 13:15
· Methotrexate and NSAIDS 13:23
· Lithium and Table Salt 14:00
· Pharmacokinetics – Metabolism, Statins and Grapefruit 14:55
· Liver Enzymes: Inducers and Inhibitors 15:30
· Pharmacodynamics 16:28
· Desired Additive Mechanisms of Action 17:01
· Undesired Additive Side Effects 18:49
· Concerns? 20:00
Questions and comments to druggistforthepeople@gmail.com
Summary: In this episode we’re going to catch up with the commercials for drugs. In particular, what is a monoclonal antibody (the generic drug name ends in -mab), how do they work, and why can antibodies be used for so many different indications? These indications include being used as an antiviral (against Covid till the virus mutated), a cancer treatment, against many autoimmune diseases, asthma, osteoarthritis, organ rejection and many other conditions. Drugs made from living organisms are called biologics - these monoclonal antibodies fall into this category and are specifically targeted therapies that represent a powerful, new and evolving tool in medicine.
Topics Covered:
· Monoclonal Antibody (-mab) – big molecule 01:23
· Antigen 02:30
· Mab Production (Biologic) 03:15
· Mab Uses 04:10
· Targeted Therapy 04:40
· Desired Effect & Collateral Damage 05:30
· Prednisone 06:05
· Rheumatoid Arthritis & Inflammatory Bowel Disease 07:19
· Specificity 07:55
· Infection Risk 08:24
· MD Discussion/Shared Decision Making 09:40
· Positive, Informed and Following Up 10:30
· Insulin and Monoclonal Antibody – Injection 11:00
· Small Molecule Targeted Immunotherapy (-ib) 13:57
· Rinvoq (upadacitinib) 15:15
· JAK Inhibitors 16:23
Questions and comments to druggistforthepeople@gmail.com
Summary: This podcast is about what most men know nothing about: Breastfeeding (let’s leave it at that). And in particular, it’s about how to determine what medications it’s okay to take and to continue to breastfeed. Also addressed is the essential component of forming a team to guide a mother through deciding about lactation and medication. To be effective, this trio of Mother/Pediatrician-MD/Pharmacist must have open communication channels amongst them and be anchored by an Empowered Mom.
Topics Covered:
· Breastfeeding Recent Trends 02:12
· Parlodel (Bromocriptine) 02:35
· Risk-Benefit 03:15
· Post-Marketing Information (MedWatch) 03:28
· Pump and Dump 04:22
· Lactation and Medication Trends 06:00
· Randomized Clinical Trials – Not 06:25
· Drugs Into Milk 07:22
· When is it Safe? 08:11
· Resource Variability (American Academy of Pediatricians) 08:36
· Drug Into Infant? 09:45
· Your Team 12:27
· YOU/Pediatrician-MD/Pharmacist 12:37
· Lactation and Medication Search 12:54
· Communication Channels Open 13:49
· Yourself Empowered 14:00
· Mom and Infant Risk-Benefit 15:00
Questions and comments to druggistforthepeople@gmail.com
Summary: Alzheimer’s. Anyone who has dealt with this disease knows the pain and frustration of losing a loved one, while their heart still beats. Discussed here is an overview of the drugs that have long been available, the drugs that are new for the treatment of Alzheimer’s, and the avenues being explored for the development of future medications and treatments. Tying this together is the very real effect of attitude and expectation, taught to me by my Dad.
Topics Covered:
· Unwarranted Optimism 01:30
· Aricept 03:00
· Exelon, Reminyl and Memantine 03:28
· Beta Amyloid Plaques 04:02
· Aduhelm 04:41
· Leqembi 05:20
· Disease Modifying Therapy 05:40
· Tau Tangles 06:25
· Decrease Inflammation & Insulin Resistance 07:05
· Heart Health 07:19
· Hormones 07:25
· Alzheimer Monoclonal Antibodies – Risk/Benefit 07:52
· Unwarranted Optimism – Dad 09:05
· Placebo and Nocebo 10:15
· Positive, Participate, Monitor and Talk with MD 12:03
Questions and comments to druggistforthepeople@gmail.com
Summary: Trying to sleep? It’s like trying to forget something: the harder you try, the more you remember. There can be no “trying” to it. There are some over-the-counter sleep aids, designed for short-term use, but they too have their drawbacks. Melatonin, Tylenol PM (diphenhydramine), Nyquil are discussed, with a brief look at Ambien (will be discussed at length in future podcast). Discussing OTC sleep aids with your doctor and pharmacist is always a good idea. Long-term solutions such as sleep hygiene and relaxation are also addressed.
Topics Covered:
· Forgetting How to Sleep 01:25
· Routine and Relaxation 01:42
· Drugs as a part of the Routine 02:19
· The Harder You Try the Less You Do 02:35
· Melatonin 02:56
· Sleep Hygiene 04:35
· Tylenol PM 04:52
· Ambien – CIV 05:33
· Nyquil 07:35
· Tolerance vs. Habit 08:45
· How They Work 12:25
· Summary 12:44
· Precautions with Antihistamines 13:34
druggistforthepeople@gmail.com
Questions and comments to druggistforthepeople@gmail.com
In this episode, the question at hand is “What is this stuff?” It’s albuterol, a beta-2 selective drug, used as a rescue inhaler. And the question remains: “What is this stuff?” When it was invented, why it works and when is too much too much. And why communicating with your physician about your Albuterol use is so important. Everything is connected, and so we also spend a couple of minutes talking about Epi-Pen, another rescue medication.
Topics Covered:
- Albuterol. What the hell is this stuff? 1:08
- Snake 1:50
- Fight or Flight 2:22
- Selective Drug 3:10
- Mimics Natural Process 4:20
- Too Much? 5:40
- Other Options 6:00
- Losing Selectivity 7:22
- Sympathetic vs. Parasympathetic 8:07
- Before Albuterol 9:10
- Epipen 10:00
Questions and comments to druggistforthepeople@gmail.com
In this introductory episode, Donald Schoeff, RPh, with over 40 years of experience as a Clinical Pharmacist in a variety of Pharmacy settings, will discuss information to help people better understand their medications, what questions to ask their doctor or pharmacist and why it is important to participate in this shared decision making with your physician (consider when to take medications). This podcast is for consumers who don’t necessarily have a medical background. The podcast also takes a look at evolving medical information and medications. Poison or prescription? Balance in the body?
Topics Covered:
- Participate 05:15
- Empowered 7:00
- Shared Decision Making 7:52
- The Right Image 9:12
- Doctors Are People, Too 10:25
- How to Play 13:20
- Evolving Treatments 14:10
- Walkin’-Talkin’ Miracles 15:15
- Poison or Prescription? 16:59
- Suspicious of Science and Medicine 19:00
- Letters and Atoms 20:45
- Your Pharmacist – Use Them! 23:29
Questions and comments to druggistforthepeople@gmail.com