Critical Care Reviews Podcast: Recent Episodes
Rob Mac Sweeney
The Critical Care Reviews Podcast discusses the biggest critical care trials, either planned or in progress, with their chief investigators. It's hosted by Rob Mac Sweeney, an intensivist in Belfast, Northern Ireland.
Rob Mac Sweeney discusses the ACIOS study with Tim Baker, the study lead. ACIOS is a point prevalence study describing the burden of critical illness in Africa. It was published in the Lancet in March, 2025.
Rob Mac Sweeney discusses the IVIO trial with investigators Lars Wiuff Andersen and Mikael Fink Valentine from Aarhus, Denmark. The IVIO trial compared intraosseous with intravenous vascular access in adult patients suffering an out-of-hospital cardiac arrest. It was presented at the 2024 European Resuscitation Council congress in Athens and simultaneously published in the New England Journal of Medicine.
Rob Mac Sweeney discusses the PARAMEDIC 3 trial with it's investigators Keith Couple and Ranjit Lall from the University of Warwick, England. PARAMEDIC 3 compared intravenous with intraosseous vascular access in adult patients suffering cardiac arrest and requiring drug administration during ongoing resuscitation. It was presented at the European Resuscitation Council meeting in Athens on October 31st and simultaneously published in the New England Journal of Medicine.
Rob Mac Sweeney chats with Jessica Spence about the B-FREE trial, investigating benzodiazepine-free anaesthesia for the prevention of delirium in cardiac surgery
Bala Venkatesh (Brisbane) hosts a panel discussion entitled "Beyond Platform Trials" at the Critical Care Reviews Meeting 2023. The panellists include Bronagh Blackwood (Belfast), Susan Rowell (Chicago), Fernando Zampieri (Edmonton), Marion Campbell (Aberdeen), David Harrison (London), Roger Lewis (Los Angeles), Derek Angus (Pittsburgh) & Kathy Rowan (London).
Kathy Rowan (London) hosts a fascinating panel discussion on causality at the Critical Care Reviews Meeting 2023. The panellists include Bronwen Connolly (Belfast), Ewan Goligher (Toronto), Flavia Machado (Sao Paulo), Kath Maitland (Kalifi), John Norrie (Edinburgh), Victoria Cornelius (London), Andrew Althouse (Pittsburgh) and Chris Seymour (Pittsburgh).
Dr Lisa Higgins (Melbourne) presents the long term outcomes of the REMAP-CAP domains at the Critical Care Reviews Meeting 2023. Prof Howard Bauchner (Boston) delivers an editorial. Prof Christopher Seymour (Pittsburgh) chairs the session.
Nina Christine Andersen-Ranberg presents the AID-ICU trial, investigating haloperidol for the management of delirium in the ICU. Danny McAuley delivers an editorial. Anders Perner joins the discussion and the session is chaired by Paul Mouncey.
Prof Flavia Machado (Sao Paulo) delivers the John Hinds Lecture at the Critical Care Reviews Meeting 2023, describing the story of BRICNET, the Brazilian Critical Care Trials Group. The session commences with Dr Chris Nutt remembering our friend, Dr John Hinds.
You're listening to the audio version of the PROCOAG trial presentation from the Critical Care Reviews Meeting 2023. The PROCOAG trial investigated the efficacy and safety of early administration of 4-factor prothrombin complex concentrate in trauma patients at risk of massive transfusion. The trial is presented by Pierre Bouzat from Grenoble. Susan Rowell from Chicago, delivers the editorial. The session is chaired by Chris Seymour (Pittsburgh). PROCOAG was published in JAMA in March 2023.
You're listening to the audio version of the TEAM trial presentation from the Critical Care Reviews Meeting 2023. The TEAM trial investigated early active mobilisation in critically ill mechanically ventilated patients. The trial is presented by Carol Hodgson from Melbourne. Darren Taichman from Philadelphia, delivers the editorial. The session is chaired by Paul Mouncey (Pittsburgh).
Matthew Semler (Nashville, USA) presents the PILOT trial at the Critical care Reviews Meeting 2023, in Titanic Belfast. The PILOT trial compared low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Kath Maitland from Kigali, Kenya, delivers an independent editorial. The session is chaired by Chris Seymour from Pittsburgh, USA. PILOT was published in the New England Journal of Medicine on November 10th, 2022.
Dr Francois Lamontagne joins Rob Mac Sweeney to discuss the harmonised REMAP-CAP / LOVIT-COVID vitamin C trial. The trial was presented at the European Society of Intensive Care Medicine annual congress and simultaneously published in the New England Journal of Medicine.
Mark Peters and Doug Gould (both London) present the results of the OXY-PICU trial, comparing conservative with liberal oxygenation targets (SpO2 88-92% vs >94%) in critically ill children receiving invasive mechanical ventilation. Luregn Schlapbach (Zurich) delivers an independent editorial. They are joined by Victoria Cornelius (London), Bronagh Blackwood (Belfast), & Matthew Semler (Nashville) for a panel discussion. The session is chaired by Howard Bauchner (Boston).
Scott Berry (Austin) and Danny McAuley (Belfast) join Rob Mac Sweeney to discuss the results of the statin domain of the REMAP-CAP trial, investigating 80mg once daily of simvastatin in critically ill patients with COVID-19.
Jan Jansen (Birmingham, USA) & Marion Campbell (Aberdeen) present the results of the UK-REBOA trial, investigating the use of REBOA in trauma patients with severe non-compressible torso haemorrhage. The editorial is delivered by John Holcomb (also from Birmingham, USA) and the session is chaired by Catriona Kelly from Dublin. The panel discussing the trial are Diana Cimpoesu (Ilsa, Romania), Caroline Leech (Coventry), Stephen Bernard (Melbourne) and Roger Lewis (Los Angeles).
Profs Nikki Curry (Oxford) and Karim Brohi (London) present the results of the CRYOSTAT-2 trial, evaluated early & empiric high-dose cryoprecipitate in patients with major traumatic haemorrhage. The editorial is delivered by Susan Rowell (Chicago) and the session is chaired by Phil Gillen from Belfast. The panel discussing the trial are Russell Gruen (Canberra), Caroline Leech (Coventry), John Holcomb (Birmingham, USA), Andrew Althouse (Pittsburgh) and co-investigator Simon Stanworth from Oxford.
Prof Ivor Douglas (Denver, USA) presents the CLOVERS trial, comparing an early restrictive fluid strategy with an early liberal fluid strategy in adult patients with sepsis-induced hypotension. Prof Fernando Zampieri (Edmonton, Canada), delivers an editorial. The session is chaired by Dr Paul Mouncey (London, England).
Russell Gruen, Brian Burns and Stephen Bernard present the results of the PATCH-Trauma trial, investigating tranexamic acid in severe trauma. An independent editorial is delivered by Karim Brohi (London). Caroline Leech (Coventry) chairs a panel discussion consisting of Susan Rowell (Chicago), Carol Hodgson (Melbourne), John Holcomb (Birmingham, USA) and John Norrie (Edinburgh).
Glenn Eastwood presents the results of the TAME cardiac arrest trial, investigating mild hypercapnoea post cardiac arrest. He is joined by senior investigators Alistair Nichol (Dublin) and Stephen Bernard (Melbourne). An independent editorial is delivered by Lars Andersen (Aarhus). Darren Taichman (Philadelphia) chairs a panel discussion consisting of Flavia Machado (Sao paulo), Joyce Yeung (Birmingham, UK) and Andrew Althouse (Pittsburgh), as well as the other speakers.
Profs Matthew Prekker (Minneapolis) and Matthew Semler (Nashville) present the results of the DEVICE trial, comparing direct with video laryngoscopy for emergency intubation in the critically ill. Prof Ellen O'Sullivan (Dublin) delivers an editorial, followed by a panel discussion including Prof David Harrison (London), Dr Caroline Leech (Coventry), Dr Fiona Kelly (Bath) and Prof Alistair Nichol (Dublin). The session was chaired by Dr Catriona Kelly (Dublin).
These results were presented at the Critical Care Reviews Meeting 2023, held in Titanic Belfast on June 16th. The DEVICE trial was simultaneously published in the New England Journal of Medicine.
Profs Giovanni Landoni and Giacomo Monti present the results of the MERCY trial, comparing bolus administration with continuous infusion of meropenem in critically ill patients with sepsis and septic shock. The results were presented at the Critical Care Reviews Meeting 2023, in Titanic Belfast. Prof Flavia Machado (Sao Paulo) delivers an editorial. The panel discussion incldues Profs Kathy Rowan (London), Victoria Cornelius (London), Ivor Douglas (Denver) and Ewan Goligher (Toronto). The session was chaired by Chris Nutt (Belfast).
John Myburgh and Ian Seppelt (Sydney) present the results of the SuDDICU trial at the Critical Care Reviews Meeting 2022, in Titanic Belfast. SuDDICU investigates selective digestive decontamination in critically ill mechanically ventilated patients. Naomi Hammond (Sydney) follows with a presentation of a systematic review and meta analysis also on SDD. John Marshall (Toronto) delivers an editorial. Danny McAuley (Belfast), Bodil Steen Rasmussen (Aalborg) and Victoria Cornelius (London) join the presenters for a panel discussion. The session is chaired by Chris Seymour (Pittsburgh).
Matthew Semler presents the results of the PILOT trial, comparing low, intermediate and high oxygenation targets in critically ill mechanically ventilated patients. Paul Young delivers an editorial and Chris Nutt asks questions from the viewers. The expert panel discussion includes Victoria Cornelius, Angelique de Man, Bodil Steen Rasmussen and Gilles Capellier. The paper was simultaneously published in the New England Journal of Medicine.
Prof Jan Belohlavek (Prague, Czech Republic) presents the Prague Out-of-Hospital Cardiac Arrest Study at the Critical care Reviews Meeting 2022. This study investigates the efficacy of an eCPR programme in patients with refractory out-of-hospital cardiac arrest. Dr Liz Wilcox (Toronto, Canada) follows with an editorial on the trial.
Lars Andersen (Aarhus, Denmark) presents the VAM-IHCA trial on June 15th at the Critical Care Reviews Meeting 2022, in Titanic Belfast. The VAM-IHCA trial investigates the combination of vasopressin and methylprednisolone in in-hospital cardiac arrest. Chris Seymour (Pittsburgh, USA) delivers an editorial after the trial presentation. The session is chaired by Catriona Kelly (Dublin, Ireland).
Nick Crombie (Birmingham, England) presents the RePHILL trial, comparing pre-hospital administration of saline with blood products in patients with trauma-related haemorrhagic shock. Liz Wilcox (Toronto, Canada) delivers an editorial. The session is chaired by Catriona Kelly (Dublin, Ireland).
Derek Russell (Birmingham, USA) and Jon Casey (Nashville, USA) presents the results of the PREPARE II trial, investigating fluid bolus therapy for the prevention of cardiovascular collapse during emergency intubation. Anthony Gordon (London, England) delivers an editorial, which is followed by a panel discussion including Lennie Derde (Utrecht, the Netherlands), Andrew Althouse (Pittsburgh, USA), Elizabeth Wilcox (Toronto, Canada) and Lars Andersen (Aarhous, Denmark). The session is chaired by Chris Seymour from the USA. PREPARE II was simultaneously published in JAMA.
Dr Tine Sylvest Meyhoff (Copenhagen, Denmark) presents the results of the CLASSIC trial at the Critical Care Reviews Meeting 2022. Prof Katryn Maitland (Kalifi, Kenya) delivers an editorial, which is followed by a panel discussion including Prof David Harrison (London, England), Dr Lennie Derde (Utrecht, the Netherlands), Dr Jon Silversides (Belfast, Northern Ireland), and the chief investigator for CLASSIC, Prof Anders Perner (Copenhagen, Denmark). The session is chaired by Prof Bala Venkatesh from Brisbane, Australia.
Drs Padmanabhan Ramnarayan and Paul Mouncey (both London) present the results of the FIRST-ABC trial, comparing high-flow nasal cannulae therapy with CPAP in acute ill children with respiratory failure, at the Critical Care Reviews Meeting 2022. Dr Srinivas Murthy (Vancouver) delivers an editorial, which is followed by a panel discussion including Profs Kathryn Maitland (Kalifi), John Marshall (Toronto) and Marion Campbell (Aberdeen). The session is chaired by Prof Howard Bauchner.
Rob Mac Sweeney (Belfast, Northern Ireland) hosts a panel discussion including Prof Paul Checchia (Houston, USA), Prof Wes Diddle (Washington DC, USA), Prof Ranjit Lall (Coventry, England), Prof Kathy Rowan (London, England), as well as the NITRIC trial chief investigator Luregn Schlapbach (Zurich, Switzerland) and editorialist Prof Mark Peters (London, England)
Dr Bronwen Connolly asks cheif investigator Luregn Schlapbach questions from the viewers during the livestream of the NITRIC trial results
Prof Mark Peters, from Great Ormond Street Hospital, delivers an editorial on the NITRIC trial, investigating nitric oxide during cardiac surgery for children with congenital cardiac disease. The chief investigator for the trial Assoc Prof Luregn Schlapbach replies.
Assoc Prof Luregn Schlapbach (Zurich, Switzerland) presents the results of the NITRIC trial, investigating nitric oxide during cardiac surgery for children with congenital cardiac disease.
Rob Mac Sweeney hosts a panel discussion on the results of the FIRST ABC trial, comparing HFNO with CPAP in recently extubated children. The panelists are Martha A.Q. Curley (Philadelphia), Christopher M. Horvat (Pittsburgh), Martin Kneyber (Groningen), and David Harrison (London). They are joined by Padmanabhan Ramnarayan (chief investigator), Alvin Richards-Belle (trial manager) and Adrienne Randolph (editorialist).
Chris Nutt (Belfast) asks the chief investigator of the FIRST-ABC trial Padmanabhan Ramnarayan (London) questions from the viewers during the livestream presentation of the trial results.
Adrienne Randolph (Boston) delivers an independent editorial on the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.
Dr Padmanabhan Ramnarayan (London) and Mr Alvin Richards-Belle (London) present the results of the FIRST-ABC (Step Down) trial, comparing high flow nasal oxygen with continuous positive airway pressure in recently extubated children.
Pär Johansson from Copenhagen joins Rob Mac Sweeney to discuss the fascinating phase II COMBAT-COVID trial, investigating prostacyclin in intubated patients with COVID-19 and severe
endotheliopathy. The trial was published in the American Journal of Respiratory and Critical Care Medicine in November 2021.
Naomi Hammond and Simon Finfer join Rob Mac Sweeney to discuss the reaction of the critical care community to the presentation and publication of both the PLUS trial and the systematic review and meta analysis comparing balanced solutions with 0.9% saline in the critically ill.
Drs Brian Driver and Matt Prekker join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BOUGIE trial, comparing the use of a stylet with that of a bougie in emergency intubation.
Dr Rob Mac Sweeney (Belfast, Northern Ireland) chairs a panel discussion on the results of the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in either the emergency department or the ICU. The panelists are Prof Jonathan Benger (Bristol, England), Dr George Kovacs (Halifax, Canada), Dr Jean-Baptiste (Nantes, France) and Prof Sheila Myatra (Mumbai, India). They are joined by the trialists Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA), Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nashville, USA).
Dr Chris Nutt (Belfast, Northern Ireland) asks questions posed by viewers of the BOUGIE trial results presentation livestream. These are answered by Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA). Prof Jonathan Benger (Bristol, England) also joins the discussion.
Prof Sheila Myatra (Mumbai, India) delivers an independent editorial on the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU. Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA) reply to the editorial and Prof Jonathan Benger (Bristol, England) also joins the discussion.
Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA) and Dr Brian Driver (Minneapolis, USA) present the results of the BOUGIE trial at a Critical Care Reviews Trial Results Livestream, on December 8th, 2021. The BOUGIE trial compared the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU.
Theresa Olasveengen (Oslo, Norway), Victoria Cornelius (London, England) and Christopher Seymour (Pittsburgh, USA) join trialists Mikael Fink Vallentin and Lars Andersen (Aarhus, Denmark), as well as editorialist Gavin Perkins (Coventry, England), to discuss the COCA trial.
Dr Chris Nutt asks Dr Mikael Fink Vallentin and Lars Andersen questions form the viewers, during the livestream presentation of the COCA trial results. The COCA trial investigates calcium for out-of-hospital cardiac arrest and was presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.
Drs Mikael Fink Vallentin and Lars Andersen (University of Aarhus, Denmark) present the results of the COCA trial, investigating calcium for out-of-hospital cardiac arrest. The COCA trial results were presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.
Prof Gavin Perkins (University of Warwick) delivers an editorial on the COCA trial, investigating calcium for out-of-hospital cardiac arrest. The COCA trial results were presented at a Critical Care Reviews Trial Results Presentation Livestream on November 30th, 2021, with a simultaneous publication in JAMA.
Dr Bharath Kumar presents preliminary results of the HOPE trial and discusses the difficulties of undertaking research during a pandemic.
Bram Rochwerg (Hamilton, Canada), Paul Mouncey (London, England) & Colin McArthur (Auckland, New Zealand) join trialists Sheila Nainan Myatra (Mumbai, India), Bala Ventakesh (Brisbane, Australia) and Anders Perner (Copenhagen, Denmark), as well as editorialists Marion Campbell (Aberdeen, Scotland), to discuss the COVID STEROID 2 trial.
Chris Nutt (Belfast) asks investigators Sheila Nainan Myatra, Bala Venkatesh & Anders Perner questions from the viewers during the D STEROID 2 Trial Results Presentation. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on October 21st, 2021
Prof Marion Campbell (Aberdeen, Scotland) delivers an editorial on the COVID STEROID 2 Trial, comparing 12mg with 6mg of dexamethasone in patients with severe COVID-19 and hypoxia, at a Critical Care Reviews Trial Result Livestream, on October 21st, 2021.
Sheila Nainan Myatra (Mumbai, India), Bala Ventakesh (Brisbane, Australia), Anders Perner (Copenhagen, Denmark) present the results of the COVID STEROID 2 Trial, comparing 12mg with 6mg of dexamethasone in patients with severe COVID-19 and hypoxia, at a Critical Care Reviews Trial Result Livestream, on October 21st, 2021.
Chief investigator Lars Andersen joins Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the VAM-IHCA trial results, investigating vasopressin and methylprednisolone for in-hospital cardiac arrest.
Rob Mac Sweeney (Belfast) hosts an expert panel to discuss the findings of the VAM-IHCA trial, investigating vasopressin and methylprednisolone for in-hospital cardiac arrest. The panel consists of Katherine Berg (Boston), Bernd Botttiger (Cologne), Ranjit Lall (Coventry), Louise Morrison (Toronto), Spyros Mentzelopoulos (Athens), Lars Wiuff Andersen & Asger Granfeldt (Aarhus), and Spyros Mentzelopoulos (Athens). This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021.
Chris Nutt (Belfast) poses questions from the viewers to the lead investigators of the VAM-IHCA trial, Lars Wiuff Andersen and Asger Granfeldt. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021.
Prof Spyros Mentzelopoulos (Athens, Greece) delivers an independent editorial on the VAM-IHCA trial, investigating vasopressin and methylprednisolone for in-hospital cardiac arrest. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021
Asger Granfeldt & Lars Wiuff Andersen (Aarhus, Denmark) present the results of the VAM-IHCA trial, investigating the combination of vasopressin and methylprednisolone for in-hospital cardiac arrest. This trial result was presented at a Critical Care Reviews Trial Results Livestream, on September 29th, 2021.
Prof Alistair Nichol (Dublin & Melbourne) discusses why the REMAP-CAP adaptive platform trial has chosen to investigate ivermectin, given the controversy surrounding this agent.
Dr Lennie Derde is the Trial Steering Committee Chair and the European Coordinating Investigator for the REMAP-CAP project. She discusses the running of the REMAP-CAP trial, her background in critical care and infectious diseases, how she got into critical care research, the background of the REMAP-CAP trial and its current workload for her. We also review the output from the trial to date and finish by considering how this pandemic is likely to progress.
BaSICS trial leads Drs Fernando Zampieri & Alexandre Biasi Cavalcante join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BaSICS trial results.
Niklas Nielsen, the chief investigator for the TTM2 trial, joins Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the TTM2 trial results.
Prof Manu Shankar-Hari, the lead for the WHO REACT group's prospective meta analysis on interleukin 6 antagonism in patients hospitalised with COVID-19, joins Rob Mac Sweeney to discuss this important work
Prof Giuseppe Citerio (Milan) joins Rob Mac Sweeney to discuss the global SYNAPSE-ICU study, investigating the use of intracranial pressure monitoring in acute brain injury.
Phil Gillen (Belfast) asks questions posed by the viewers of the TTM2 results livestream to the TTM2 trialists Niklas Nielsen, Josef Dankiewicz and Gisela Lilja.
Niklas Nielsen, Josef Dankiewicz and Gisela Lilja (all Lund) presents the results of the landmark TTM2 trial, comparing hypothermia (33°) with normothermia (<37.8°) in 1850 comatose survivors of out-of-hospital cardiac arrest.
Panellists Jerry Nolan, Kathy Rowan and Terri Hough join editorialist Stephen Bernard and TTM2 investigators Niklas Nielsen, Josef Dankiewicz and Gisela Lilja to discuss the landmark TTM2 trial at the Critical Care Reviews hosted TTM2 results livestream.
Prof Stephen Bernard (Melbourne) delivers an editorial on the TTM2 trial result, delivered as part of the Critical Care Reviews hosted TTM2 Trial Results Livestream.
Prof Derek Angus, from Pittsburgh, USA, discusses a modern healthcare system which merges research into clinical practice, producing a "learning while doing" healthcare model.
Professor Kath Maitland joins Rob Mac Sweeney to discuss the COAST trial, investigating oxygen therapy in African children with severe pneumonia.
In the latest episode on the REMAP-CAP series, Prof Alistair Nichol (Dublin / Melbourne) discuss the upcoming ventilation domain with Rob Mac Sweeney.
Professors Vincenzo Russotto and Sheila Myatra join Rob Mac Sweeney to discuss their INTUBE study, investigating tracheal intubation practices in the critically ill around the world.
Mathias Pletz discusses pandemics and the role of REMAP-CAP adaptive platform trial in responding to the COVID-19 pandemic
John Marshall and Srinivas Murthy discuss the choice of interventions in the REMAP-CAP adaptive platform trial
Scott Berry discusses the methodological and statistical framework behind the REMAP-CAP trial
Prof Steve Webb, from Perth, Australia, discusses the origin, design and execution of the REMAP-CAP adaptive platform trial
Prof Derek Angus and Prof Anthony Gordon, senior investigators for the REMAP-CAP trial, discuss the COVID-19 steroid domain results of the REMAP-CAP trial on the Critical Care Reviews Podcast
Prof Jorrit Lemkes (Amsterdam, The Netherlands) presents the COACT Trial, investigating the timing of coronary angiography in patients with cardiac arrest without ST elevation. This is followed by an editorial by Dr Chris Nickson (Melbourne, Australia). This talk was given at the Critical Care Reviews Meeting 2020, in Titanic Belfast.
Dr Paul Young describes MEGA-ROX, a registry-based, adaptive platform trial investigating oxygenation targets in the critically ill. This is followed by a panel discussion involving trialists, methodologists and statisticians on this ambitious trial design.
Dr Paul Young (Wellington, New Zealand) presents the ICU-ROX trial, investigating conservative oxygen therapy in mechanically ventilated patients in the ICU, at the Critical Care Reviews Meeting 2020, in Titanic Belfast. Prof Anders Perner (Copenhagen, Denmark) gives an editorial on this trial afterwards.
Prof Kathryn Maitland delivers the honorary John Hinds Lecture, entitled "A Higher Calling: two decades of emergency research in Africa", at the Critical Care Reviews Meeting 2020, at Titanic Belfast.
Prof Kathryn Maitland discusses the TRACT trial, investigating red blood cell transfusion in African children with anaemia, at the Critical Care Reviews Meeting 2020, at Titanic Belfast.
Prof Maureen McCunn delivers the annual honorary John Hinds Trauma Lecture at the Critical Care Reviews Meeting 2019, in Titanic, Belfast, entitled "A Culture of Excellence - The R Adams Cowley Shock Trauma Center"
Dr Lennie Derde delivers an editorial on the PreVENT trial, comparing low with intermediate tidal volumes in critically ill patients without ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Marcus Schultz presents the PreVENT trial, comparing low with intermediate tidal volumes in critically ill patients without ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Maureen McCunn delivers an editorial on the PAMPer trial, investigating plasma in prehospital trauma, at the Critical Care Reviews Meeting 2019, at Titanic, Belfast.
Prof Jason Sperry presents the PAMPer trial, investigating plasma in prehospital trauma, at the Critical Care Reviews Meeting 2019, at Titanic, Belfast.
Prof Marion Campbell delivers an editorial on the EOLIA trial, investigating ECMO in severe ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Niall Ferguson presents the EOLIA trial, investigating ECMO in severe ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Todd Rice gives an editorial on the TARGET trial, comparing energy-dense (1.5 kcal/ml) with routine (1.0 kcal/ml) enteral nutrition in critically ill patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Marianne Chapman presents the TARGET trial, comparing energy-dense (1.5 kcal/ml) with routine (1.0 kcal/ml) enteral nutrition in critically ill patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Marianne Chapman delivers an editorial on the SUP-ICU trial, investigating pantoprazole stress ulcer prophylaxis in critically ill mechanically ventilated patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Dr Morten Hylander Møller presents the SUP-ICU trial, investigating pantoprazole stress ulcer prophylaxis in critically ill, mechanically ventilated patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Anders Perner delivers an editorial on the SMART trial, comparing saline with balanced crystalloids in ICU patients, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Todd Rice discusses the SMART trial, comparing saline with balanced crystalloids in ICU patients, at the Critical Care Reviews Meeting 2019
Prof Danny McAuley chairs a panel discussion between the investigators of the trials presented in detail at day 1 of the Critical Care Reviews Meeting 2019 - POPPI (Prof Kathy Rowan), MIND-USA (Assoc Prof Timoth Girard), AI in Sepsis (Prof Anthony Gordon), ANDROMEDA-SHOCK (Prof Jan Bakker), SMART (Prof Todd Rice) and APPROCCHSS (Prof Djillali Annane)
Dr Manu Shankar-Hari delivers an editorial on the ANDROMEDA-SHOCK trial, comparing peripheral perfusion-guided with serum lactate-guided resuscitation in septic shock
Prof Jan Bakker presents the ANDROMEDA-SHOCK trial, comparing peripheral perfusion-guided with serum lactate-guided resuscitation in septic shock
Prof Danny McAuley delivers an editorial on the MIND-USA trial, comparing haloperidol, ziprasidone and placebo in critically ill mechanically ventilated patients with delirium, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast
Assoc Prof Timothy Girard presents the MIND-USA trial, comparing haloperidol, ziprasidone and placebo in critically ill mechanically ventilated patients with delirium, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Dr Bronwen Connolly delivers an editorial on the POPPI trial, investigating nurse-delivered psychological support in the ICU, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast
Prof Kathy Rowan presents the POPPI trial, investigating nurse-delivered psychological support in the ICU, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast
Prof Kathy Rowan presents an editorial on the role of artificial intelligence in sepsis, at the Critical care Reviews Meeting 2019, in Titanic, Belfast.
Prof Anthony Gordon presents data investigating the role of artificial intelligence in sepsis, at the Critical care Reviews Meeting 2019, in Titanic, Belfast
Dr Manu Shankar-Hari gives an editorial on the APPROCCHSS trial, investigating fludrocortisone and hydrocortisone, at the Critical care Reviews Meeting 2019, in Titanic Belfast
Prof Djillali Annane (Paris) presents the APPROCCHSS trial, investigating hydrocortisone and fludrocortisone in septic shock, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Anders Perner leads the panel discussion on the PHARLAP trial at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Niall Ferguson delivers the editorial on the PHARLAP trial at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
Prof Alistair Nichol presents the results of the ANZICS PHARLAP trial, investigating the open lung approach in ARDS, at the Critical Care Reviews Meeting 2019, in Titanic, Belfast.
This was a presentation of the draft results. PHARLAP has since been published in the American Journal of Respiratory and Critical Care Medicine in July 2019.
Dr Sophie Wallace (Perth, Western Australia) delivers the annual honorary John Hinds Trauma Lecture at the Critical Care Reviews Meeting 2018, in Titanic, Belfast.
Danny McAuley chairs an international panel discussion on the best critical care trials of 2017, at the Critical Care Reviews Meeting 2018, in Titanic, Belfast.
Professor Andrew Rhodes (London) discusses the latest iteration of the Surviving Sepsis Campaign at the Critical Care Reviews Meeting 2018, at Titanic, Belfast.
Prof Alexandre Biasi Cavalcanti (Sao Paulo, Brazil) discusses the ART trial, investigating recruitment manoeuvres in patients with ARDS, at the Critical Care Reviews Meeting 2018, at Titanic, Belfast.
Prof Alistair Nichol (Dublin \ Melbourne) discusses the TRANSFUSE trial, comparing fresh with standard issue red blood cells for transfusion in the critically ill, at the Critical Care Reviews Meeting 2018, at Titanic, Belfast.
Dr Jean-Baptiste Lascarrou discusses the MACMAN trial, comparing video laryngoscopy with direct laryngoscopy in the ICU, at the Critical Care Reviews Meeting 2018, at Titanic, Belfast.
Asst Prof Ashish Khanna (Cleveland, USA) discusses the ATHOS-3 trial, investigating angiotensin II in vasodilatory shock at the Critical Care Reviews Meeting 2018 in Belfast. Prof Anthony Gordon (London, England) provides a brief editorial afterwards.
Prof Donat Spahn describes how he manages trauma at the Critical Care Reviews Meeting 2017 in Titanic, Belfast
Dr Gonzalo Hernandez (Madrid) describes how he uses high flow nasal oxygen at the Critical Care Reviews Meeting, held in Titanic, Belfast in January 2017.
John Myburgh (Sydney) describes how he manages IV fluids at the Critical Care Reviews Meeting 2017, in Titanic, Belfast.
Mervyn Singer (London) describes how he manages antibiotics at the Critical Care Reviews Meeting 2017, in Titanic, Belfast.
The faculty of the Critical Care Reviews Meeting 2017 discuss the other big trials of 2016 and future directions of studies.
Prof John Myburgh (Sydney) discusses the difficulties with performing critical care research in his talk "The Path to Truth"
Donat Spahn (Zurich) delivers the annual honorary John Hinds Trauma Lecture at the Critical Care Reviews Meeting 2017 in Titanic, Belfast
Paul Marik (Norfolk, USA) describes his retrospective, before-and-after, single-centre study on the use of vitamin C, hydrocortisone and thiamine in patients with septic shock.
Dr Gonzalo Hernandez (Madrid) discusses his trial examining the use of high flow nasal oxygen post extubation in critically ill patients at the Critical Care Reviews Meeting 2017
Peter Hjortrup (Copenhagen) discusses the CLASSIC trial at the Critical Care Reviews Meeting 2017, in Titanic, Belfast.
Greet Van den Berghe (Leuven) discusses the PEPaNIC trial at the Critical Care Reviews Meeting, in Titanic, Belfast
Peter Hutchinson (Cambridge) discusses the RESCUEicp trial at the Critical Care Reviews Meeting 2017, in Titanic, Belfast
Mervyn Singer discusses the new SEPSIS 3.0 definition at the Critical Care Reviews Meeting 2017, at Titanic, Belfast.
Shay McGuinness from Auckland, New Zealand, discuss the ongoing PEPTIC Trial with Rob Mac Sweeney, on the Critical Care Reviews Podcast
Glenn Eastwood from Melbourne, Australia, discusses the TAME cardiac arrest trial with Rob Mac Sweeney, on the Critical Care Reviews Podcast
Rob Mac Sweeney discusses the ICU-ROX trial with its chief investigator Paul Young. This trial evaluates the effect of lowering the FiO2 in mechanically ventilated patients in the ICU.